DNASE1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of phospholipase A2 activity (GO:0032429)6.99486571
2epoxygenase P450 pathway (GO:0019373)6.72467659
3exogenous drug catabolic process (GO:0042738)6.39112393
4drug catabolic process (GO:0042737)6.25760551
5cellular response to exogenous dsRNA (GO:0071360)6.12768442
6iron ion import (GO:0097286)5.79687485
7antigen processing and presentation of endogenous antigen (GO:0019883)5.74098692
8microglial cell activation (GO:0001774)5.63203361
9omega-hydroxylase P450 pathway (GO:0097267)5.38634848
10oligosaccharide catabolic process (GO:0009313)5.37228490
11pinocytosis (GO:0006907)5.36876203
12positive regulation by symbiont of host defense response (GO:0052509)5.35065541
13modulation by symbiont of host defense response (GO:0052031)5.35065541
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.35065541
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.35065541
16positive regulation by organism of defense response of other organism involved in symbiotic interact5.35065541
17modulation by symbiont of host immune response (GO:0052553)5.35065541
18regulation of dendritic cell antigen processing and presentation (GO:0002604)5.29937511
19import into cell (GO:0098657)5.16301964
20glycosphingolipid catabolic process (GO:0046479)5.09702155
21drug metabolic process (GO:0017144)5.06346429
22sphingolipid catabolic process (GO:0030149)5.04501681
23ethanol oxidation (GO:0006069)5.01780578
24complement activation, classical pathway (GO:0006958)4.88550977
25positive regulation of interferon-alpha production (GO:0032727)4.83386856
26intracellular pH reduction (GO:0051452)4.73631998
27positive regulation of T cell mediated cytotoxicity (GO:0001916)4.65077653
28ceramide catabolic process (GO:0046514)4.63278267
29complement activation (GO:0006956)4.60991555
30complement activation, alternative pathway (GO:0006957)4.57421344
31glycolipid catabolic process (GO:0019377)4.57317443
32positive regulation of antigen processing and presentation (GO:0002579)4.51476655
33regulation of interferon-alpha production (GO:0032647)4.51358049
34membrane lipid catabolic process (GO:0046466)4.50684768
35positive regulation of monocyte chemotaxis (GO:0090026)4.39285414
36regulation of T cell mediated cytotoxicity (GO:0001914)4.37577589
37regulation of triglyceride catabolic process (GO:0010896)4.26242862
38regulation of interferon-beta biosynthetic process (GO:0045357)4.21623489
39detection of bacterium (GO:0016045)4.16699131
40protein activation cascade (GO:0072376)4.09970692
41positive regulation of chemokine biosynthetic process (GO:0045080)4.08150306
42regulation of protein activation cascade (GO:2000257)4.06177628
43cellular response to interferon-beta (GO:0035458)3.99820961
44regulation of complement activation (GO:0030449)3.97046876
45flavonoid metabolic process (GO:0009812)3.94488145
46oxidative demethylation (GO:0070989)3.93702873
47response to peptidoglycan (GO:0032494)3.92967613
48respiratory burst (GO:0045730)3.92111055
49regulation of B cell receptor signaling pathway (GO:0050855)3.91058448
50angiotensin maturation (GO:0002003)3.90903296
51bile acid and bile salt transport (GO:0015721)3.90259345
52ethanol metabolic process (GO:0006067)3.88347929
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.87477067
54disruption of cells of other organism (GO:0044364)3.85501374
55killing of cells of other organism (GO:0031640)3.85501374
56regulation of antigen processing and presentation (GO:0002577)3.82337981
57arginine metabolic process (GO:0006525)3.81871694
58positive regulation of cellular amide metabolic process (GO:0034250)3.80949167
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78701257
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78701257
61phenylpropanoid metabolic process (GO:0009698)3.78514768
62bile acid metabolic process (GO:0008206)3.76882104
63regulation of guanylate cyclase activity (GO:0031282)3.68294875
64pH reduction (GO:0045851)3.65830683
65detection of other organism (GO:0098543)3.64602066
66urea cycle (GO:0000050)3.58644567
67urea metabolic process (GO:0019627)3.58644567
68amine catabolic process (GO:0009310)3.55522352
69cellular biogenic amine catabolic process (GO:0042402)3.55522352
70alkaloid metabolic process (GO:0009820)3.54994836
71indole-containing compound catabolic process (GO:0042436)3.51325431
72indolalkylamine catabolic process (GO:0046218)3.51325431
73tryptophan catabolic process (GO:0006569)3.51325431
74indolalkylamine metabolic process (GO:0006586)3.48577049
75hormone catabolic process (GO:0042447)3.48486012
76glyoxylate metabolic process (GO:0046487)3.47438791
77fat-soluble vitamin biosynthetic process (GO:0042362)3.46629407
78thrombin receptor signaling pathway (GO:0070493)3.44977127
79protein-lipid complex remodeling (GO:0034368)3.43729487
80macromolecular complex remodeling (GO:0034367)3.43729487
81plasma lipoprotein particle remodeling (GO:0034369)3.43729487
82antibacterial humoral response (GO:0019731)3.43139578
83response to host immune response (GO:0052572)3.42540697
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42540697
85positive regulation of interleukin-12 production (GO:0032735)3.42432638
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41466580
87intestinal absorption (GO:0050892)3.40508744
88positive regulation of respiratory burst (GO:0060267)3.40472758
89aromatic amino acid family catabolic process (GO:0009074)3.39539452
90macrophage activation involved in immune response (GO:0002281)3.36699261
91response to muramyl dipeptide (GO:0032495)3.35528828
92L-phenylalanine catabolic process (GO:0006559)3.34920378
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34920378
94membrane raft organization (GO:0031579)3.29016232
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26212600
96regulation of monocyte chemotaxis (GO:0090025)3.23002179
97nitrogen cycle metabolic process (GO:0071941)3.22945325
98antimicrobial humoral response (GO:0019730)3.22830690
99positive regulation of T cell migration (GO:2000406)3.21898716
100low-density lipoprotein particle remodeling (GO:0034374)3.21139052
101regulation of T cell migration (GO:2000404)3.20871478
102immunoglobulin mediated immune response (GO:0016064)3.19935970
103regulation of chemokine biosynthetic process (GO:0045073)3.19792275
104imidazole-containing compound metabolic process (GO:0052803)3.19340635
105negative regulation of B cell proliferation (GO:0030889)3.17185790
106arginine catabolic process (GO:0006527)3.14116159
107kynurenine metabolic process (GO:0070189)3.14114245
108tryptophan metabolic process (GO:0006568)3.11632460
109phospholipid efflux (GO:0033700)3.05457851
110L-phenylalanine metabolic process (GO:0006558)3.04884740
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.04884740
112benzene-containing compound metabolic process (GO:0042537)3.03401708
113macrophage activation (GO:0042116)3.02973863
114regulation of cellular extravasation (GO:0002691)3.02153340
115negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.01771164
116positive regulation of icosanoid secretion (GO:0032305)3.01318744
117interferon-gamma-mediated signaling pathway (GO:0060333)3.00993660
118bile acid biosynthetic process (GO:0006699)3.00298989
119grooming behavior (GO:0007625)2.98843414
120NIK/NF-kappaB signaling (GO:0038061)2.98626056
121negative regulation of alpha-beta T cell activation (GO:0046636)2.98340251
122T cell costimulation (GO:0031295)2.97691582
123positive regulation of guanylate cyclase activity (GO:0031284)2.97066848
124regulation of fibrinolysis (GO:0051917)2.96107732
125regulation of interleukin-12 production (GO:0032655)2.95676001
126cellular ketone body metabolic process (GO:0046950)2.95315504
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95076590
128sulfation (GO:0051923)2.94449941
129lymphocyte costimulation (GO:0031294)2.94064645
130reverse cholesterol transport (GO:0043691)2.93437117
131positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91501892
132high-density lipoprotein particle remodeling (GO:0034375)2.90988719
133positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.90918694
134positive regulation of fatty acid transport (GO:2000193)2.90691121
135xenobiotic metabolic process (GO:0006805)2.89852566
136regulation of humoral immune response (GO:0002920)2.89800849
137humoral immune response (GO:0006959)2.89421755
138response to host (GO:0075136)2.89179689
139response to host defenses (GO:0052200)2.89179689
140response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89179689
141aldehyde catabolic process (GO:0046185)2.87206984
142aromatic amino acid family metabolic process (GO:0009072)2.86899692
143glucuronate metabolic process (GO:0019585)2.86875190
144uronic acid metabolic process (GO:0006063)2.86875190
145S-adenosylmethionine metabolic process (GO:0046500)2.86360742
146glycerol metabolic process (GO:0006071)2.84945829
147triglyceride homeostasis (GO:0070328)2.84397385
148acylglycerol homeostasis (GO:0055090)2.84397385
149regulation of lymphocyte migration (GO:2000401)2.83343292
150germinal center formation (GO:0002467)2.83240692
151regulation of RIG-I signaling pathway (GO:0039535)2.82583700
152regulation of cholesterol esterification (GO:0010872)2.77838292
153response to interferon-beta (GO:0035456)2.77348276
154cellular response to interferon-gamma (GO:0071346)2.76972435
155cellular glucuronidation (GO:0052695)2.73307754
156linoleic acid metabolic process (GO:0043651)2.71337615
1573-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.68172152
158purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.68172152
159negative regulation of protein activation cascade (GO:2000258)2.67861211
160lipoprotein metabolic process (GO:0042157)2.67538438
161diacylglycerol metabolic process (GO:0046339)2.67326562
162positive regulation of response to biotic stimulus (GO:0002833)2.66833964
163positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.66815146
164positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66592536
165opsonization (GO:0008228)2.66310583
166regulation of podosome assembly (GO:0071801)2.65854041
167acute-phase response (GO:0006953)2.63773999
168ketone body metabolic process (GO:1902224)2.63502191
169phospholipid homeostasis (GO:0055091)2.61320342
170positive regulation of lipoprotein lipase activity (GO:0051006)2.58752223
171positive regulation of triglyceride lipase activity (GO:0061365)2.58752223
172lipoprotein transport (GO:0042953)2.58417577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.69373382
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.18721864
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.53979401
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.31282642
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.01134694
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.94166544
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64617511
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.50291140
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.35635902
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.13587543
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.78312782
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.62413737
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.59826343
14* LXR_22158963_ChIP-Seq_LIVER_Mouse2.58164529
15VDR_22108803_ChIP-Seq_LS180_Human2.38597271
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34644656
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28842028
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28081548
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.27037503
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25880574
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.20575898
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18941481
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15013843
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94728109
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.94368326
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94028044
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91651821
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89024136
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87931466
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84064413
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81218125
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77127007
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76646213
34GATA1_22025678_ChIP-Seq_K562_Human1.74539462
35SCL_19346495_ChIP-Seq_HPC-7_Human1.70793145
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.70121481
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69693205
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.69221748
39* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68645135
40RUNX_20019798_ChIP-Seq_JUKART_Human1.65614419
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63553153
42* BCAT_22108803_ChIP-Seq_LS180_Human1.60980273
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60623305
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58185050
45ZNF274_21170338_ChIP-Seq_K562_Hela1.57326684
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.56009491
47HTT_18923047_ChIP-ChIP_STHdh_Human1.52297037
48IGF1R_20145208_ChIP-Seq_DFB_Human1.50519573
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49915978
50PU_27001747_Chip-Seq_BMDM_Mouse1.47604625
51PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46732918
52ER_23166858_ChIP-Seq_MCF-7_Human1.46355012
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46188976
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44548674
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43433534
56AR_21572438_ChIP-Seq_LNCaP_Human1.42368645
57NANOG_19829295_ChIP-Seq_ESCs_Human1.39920614
58SOX2_19829295_ChIP-Seq_ESCs_Human1.39920614
59AR_20517297_ChIP-Seq_VCAP_Human1.39448947
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39026139
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38695390
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.38141569
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36960679
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.36960679
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35859701
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35277105
67* CDX2_22108803_ChIP-Seq_LS180_Human1.34223776
68* GATA4_25053715_ChIP-Seq_YYC3_Human1.33848263
69MYB_26560356_Chip-Seq_TH2_Human1.31274926
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.31199887
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29986156
72P300_19829295_ChIP-Seq_ESCs_Human1.29595167
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29494829
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29440468
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28589508
76SPI1_23127762_ChIP-Seq_K562_Human1.24886857
77* AR_25329375_ChIP-Seq_VCAP_Human1.24429013
78SPI1_23547873_ChIP-Seq_NB4_Human1.24409860
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.24165584
80CBP_20019798_ChIP-Seq_JUKART_Human1.24133083
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24133083
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24098147
83VDR_24787735_ChIP-Seq_THP-1_Human1.23132265
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21653331
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.20444049
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19544272
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19344677
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18954068
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18029246
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17954766
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17944366
92* TCF4_22108803_ChIP-Seq_LS180_Human1.17299149
93MYC_19829295_ChIP-Seq_ESCs_Human1.17099752
94GBX2_23144817_ChIP-Seq_PC3_Human1.16718783
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15150801
96* CEBPB_22108803_ChIP-Seq_LS180_Human1.12975851
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12596642
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12428299
99* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12218324
100GATA6_21074721_ChIP-Seq_CACO-2_Human1.11908116
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11646540
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11443228
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11152457
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11081618
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.10183659
106ETV1_20927104_ChIP-Seq_GIST48_Human1.10086097
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09534960
108HNFA_21074721_ChIP-Seq_CACO-2_Human1.09214852
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08750392
110NCOR_22424771_ChIP-Seq_293T_Human1.08529879
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08225776
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07691375
113* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06890112
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06113869
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05502575
116* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05370408
117EGR1_19032775_ChIP-ChIP_M12_Human1.04481231
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.03970217
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03892832
120TAF15_26573619_Chip-Seq_HEK293_Human1.03385369
121CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03281261
122RBPJ_21746931_ChIP-Seq_IB4_Human1.03087524
123NANOG_20526341_ChIP-Seq_ESCs_Human1.02705336
124MAF_26560356_Chip-Seq_TH1_Human1.02043850
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01366003
126GATA3_26560356_Chip-Seq_TH2_Human1.01339411
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01109535
128* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00372313
129CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00028020
130KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99616467
131EZH2_22144423_ChIP-Seq_EOC_Human0.98855288
132PHF8_20622853_ChIP-Seq_HELA_Human0.98748293
133TCF4_23295773_ChIP-Seq_U87_Human0.97131826
134NFYA_21822215_ChIP-Seq_K562_Human0.97037056
135FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96922585
136IRF1_19129219_ChIP-ChIP_H3396_Human0.96669370
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96380585
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91016218
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89716225
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.88871447
141MYB_26560356_Chip-Seq_TH1_Human0.88393228
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88130350
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87006683
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86985235
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86638782
146GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83100845
147HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82830937
148GATA1_19941827_ChIP-Seq_MEL_Mouse0.81730214
149NFE2_27457419_Chip-Seq_LIVER_Mouse0.81319884
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81224012
151TAF2_19829295_ChIP-Seq_ESCs_Human0.79695998
152* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78658596
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77692112
154SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76216013
155CRX_20693478_ChIP-Seq_RETINA_Mouse0.76215993
156NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75972614
157NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75972614
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75831645
159GATA2_21666600_ChIP-Seq_HMVEC_Human0.74927503
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74499612
161PU1_27457419_Chip-Seq_LIVER_Mouse0.73637843
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.73596993
163STAT1_17558387_ChIP-Seq_HELA_Human0.72775507
164GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71721851
165GATA3_27048872_Chip-Seq_THYMUS_Human0.70458090
166TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.69322430
167VDR_24763502_ChIP-Seq_THP-1_Human0.69161987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation7.03717224
2MP0004147_increased_porphyrin_level4.75900721
3MP0002139_abnormal_hepatobiliary_system3.74152933
4MP0005360_urolithiasis3.27126645
5MP0005085_abnormal_gallbladder_physiolo3.19729556
6MP0006082_CNS_inflammation3.16940904
7MP0000685_abnormal_immune_system2.97349891
8MP0005671_abnormal_response_to2.95619660
9MP0002876_abnormal_thyroid_physiology2.47088416
10MP0002138_abnormal_hepatobiliary_system2.43213760
11MP0002148_abnormal_hypersensitivity_rea2.42313399
12MP0005464_abnormal_platelet_physiology2.41986222
13MP0003806_abnormal_nucleotide_metabolis2.26392813
14MP0005365_abnormal_bile_salt2.24980583
15MP0004510_myositis2.22082671
16MP0001790_abnormal_immune_system2.17614949
17MP0005387_immune_system_phenotype2.17614949
18MP0005025_abnormal_response_to2.14435133
19MP0002452_abnormal_antigen_presenting2.12241293
20MP0005451_abnormal_body_composition2.11908484
21MP0003436_decreased_susceptibility_to2.09592424
22MP0002419_abnormal_innate_immunity2.03763779
23MP0001853_heart_inflammation2.01948382
24MP0009785_altered_susceptibility_to2.00524645
25MP0001800_abnormal_humoral_immune1.99453256
26MP0008875_abnormal_xenobiotic_pharmacok1.94816611
27MP0002254_reproductive_system_inflammat1.90323808
28MP0005000_abnormal_immune_tolerance1.84332431
29MP0001819_abnormal_immune_cell1.79157942
30MP0003191_abnormal_cellular_cholesterol1.73912442
31MP0002723_abnormal_immune_serum1.69035237
32MP0009840_abnormal_foam_cell1.68708461
33MP0005075_abnormal_melanosome_morpholog1.68576748
34MP0010329_abnormal_lipoprotein_level1.65982387
35MP0002796_impaired_skin_barrier1.64172509
36MP0010234_abnormal_vibrissa_follicle1.62422423
37MP0002420_abnormal_adaptive_immunity1.61161272
38MP0008872_abnormal_physiological_respon1.59008047
39MP0003868_abnormal_feces_composition1.57187504
40MP0003252_abnormal_bile_duct1.52754135
41MP0002090_abnormal_vision1.49165987
42MP0005408_hypopigmentation1.47236907
43MP0009764_decreased_sensitivity_to1.46149987
44MP0003303_peritoneal_inflammation1.44908831
45MP0006292_abnormal_olfactory_placode1.43812864
46MP0005084_abnormal_gallbladder_morpholo1.39730788
47MP0003866_abnormal_defecation1.37633920
48MP0004782_abnormal_surfactant_physiolog1.36300602
49MP0004019_abnormal_vitamin_homeostasis1.35377386
50MP0005166_decreased_susceptibility_to1.27813543
51MP0002405_respiratory_system_inflammati1.25815238
52MP0003075_altered_response_to1.25755239
53MP0001845_abnormal_inflammatory_respons1.25043366
54MP0001501_abnormal_sleep_pattern1.24745685
55MP0005636_abnormal_mineral_homeostasis1.22063144
56MP0003941_abnormal_skin_development1.20406827
57MP0008469_abnormal_protein_level1.19614634
58MP0004381_abnormal_hair_follicle1.19534167
59MP0002166_altered_tumor_susceptibility1.17781952
60MP0005645_abnormal_hypothalamus_physiol1.16657994
61MP0004043_abnormal_pH_regulation1.16640008
62MP0000609_abnormal_liver_physiology1.15597055
63MP0001756_abnormal_urination1.14129348
64MP0002006_tumorigenesis1.09781743
65MP0001663_abnormal_digestive_system1.08817089
66MP0000716_abnormal_immune_system1.07115403
67MP0001986_abnormal_taste_sensitivity1.05665243
68MP0001666_abnormal_nutrient_absorption1.02599293
69MP0001764_abnormal_homeostasis1.02219984
70MP0001873_stomach_inflammation1.01972650
71MP0000383_abnormal_hair_follicle1.01450134
72MP0003195_calcinosis1.00080789
73MP0010678_abnormal_skin_adnexa0.99160505
74MP0003183_abnormal_peptide_metabolism0.97201372
75MP0002136_abnormal_kidney_physiology0.97098293
76MP0005535_abnormal_body_temperature0.96918623
77MP0005551_abnormal_eye_electrophysiolog0.96209126
78MP0001664_abnormal_digestion0.95843287
79MP0004947_skin_inflammation0.95802260
80MP0005332_abnormal_amino_acid0.95649057
81MP0000689_abnormal_spleen_morphology0.95118904
82MP0010155_abnormal_intestine_physiology0.95019708
83MP0009333_abnormal_splenocyte_physiolog0.94570317
84MP0003763_abnormal_thymus_physiology0.93023334
85MP0005310_abnormal_salivary_gland0.92678300
86MP0002118_abnormal_lipid_homeostasis0.91359098
87MP0005584_abnormal_enzyme/coenzyme_acti0.91212187
88MP0002398_abnormal_bone_marrow0.90720551
89MP0002822_catalepsy0.90632697
90MP0003453_abnormal_keratinocyte_physiol0.90573656
91MP0002928_abnormal_bile_duct0.87846004
92MP0006036_abnormal_mitochondrial_physio0.87785686
93MP0004142_abnormal_muscle_tone0.85986100
94MP0002098_abnormal_vibrissa_morphology0.85630622
95MP0005319_abnormal_enzyme/_coenzyme0.85267778
96MP0002429_abnormal_blood_cell0.84624773
97MP0000230_abnormal_systemic_arterial0.83925369
98MP0005501_abnormal_skin_physiology0.82326995
99MP0009379_abnormal_foot_pigmentation0.81305986
100MP0002837_dystrophic_cardiac_calcinosis0.79982352
101MP0000371_diluted_coat_color0.78916869
102MP0005448_abnormal_energy_balance0.78021795
103MP0005083_abnormal_biliary_tract0.77953760
104MP0004145_abnormal_muscle_electrophysio0.77181343
105MP0001958_emphysema0.77062061
106MP0009763_increased_sensitivity_to0.76877615
107MP0001765_abnormal_ion_homeostasis0.75650257
108MP0002971_abnormal_brown_adipose0.71866377
109MP0003724_increased_susceptibility_to0.71625719
110MP0001485_abnormal_pinna_reflex0.71061353
111MP0003172_abnormal_lysosome_physiology0.70841365
112MP0009765_abnormal_xenobiotic_induced0.70225671
113MP0005165_increased_susceptibility_to0.70075259
114MP0003011_delayed_dark_adaptation0.68657647
115MP0000767_abnormal_smooth_muscle0.67823558
116MP0005646_abnormal_pituitary_gland0.67612494
117MP0000538_abnormal_urinary_bladder0.67562558
118MP0001905_abnormal_dopamine_level0.67328297
119MP0002722_abnormal_immune_system0.66820784
120MP0002277_abnormal_respiratory_mucosa0.66475074
121MP0000598_abnormal_liver_morphology0.65747838
122MP0003718_maternal_effect0.65453156
123MP0001970_abnormal_pain_threshold0.65381897
124MP0003879_abnormal_hair_cell0.65134809
125MP0009643_abnormal_urine_homeostasis0.63988574
126MP0001216_abnormal_epidermal_layer0.63552648
127MP0005647_abnormal_sex_gland0.63205932
128MP0005381_digestive/alimentary_phenotyp0.62891459
129MP0005670_abnormal_white_adipose0.62717911
130MP0006072_abnormal_retinal_apoptosis0.62665043
131MP0000465_gastrointestinal_hemorrhage0.61995155
132MP0003300_gastrointestinal_ulcer0.61951866
133MP0002078_abnormal_glucose_homeostasis0.61673762
134MP0002733_abnormal_thermal_nociception0.61146163
135MP0000343_altered_response_to0.60965480
136MP0002693_abnormal_pancreas_physiology0.60554788
137MP0002638_abnormal_pupillary_reflex0.59580266
138MP0003638_abnormal_response/metabolism_0.59378533
139MP0009642_abnormal_blood_homeostasis0.58693716
140MP0005275_abnormal_skin_tensile0.56357471
141MP0003045_fibrosis0.56007489
142MP0000639_abnormal_adrenal_gland0.55225531
143MP0003953_abnormal_hormone_level0.55157379
144MP0000516_abnormal_urinary_system0.53619874
145MP0005367_renal/urinary_system_phenotyp0.53619874

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)7.36062507
2Increased neuronal autofluorescent lipopigment (HP:0002074)6.21492888
3Arthropathy (HP:0003040)6.18193534
4Increased cerebral lipofuscin (HP:0011813)5.52517205
5Loss of speech (HP:0002371)5.27484875
6Abnormality of liposaccharide metabolism (HP:0010968)4.67526116
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.67526116
8Abnormality of glycolipid metabolism (HP:0010969)4.67526116
9Elevated erythrocyte sedimentation rate (HP:0003565)4.28126692
10Gastrointestinal infarctions (HP:0005244)4.21594277
11Azoospermia (HP:0000027)4.14614209
12Abnormality of proline metabolism (HP:0010907)4.08198621
13Hydroxyprolinuria (HP:0003080)4.08198621
14Myositis (HP:0100614)4.06770913
15Paralysis (HP:0003470)3.89921019
16* Cerebral palsy (HP:0100021)3.64164605
17Optic neuritis (HP:0100653)3.60890266
18Retrobulbar optic neuritis (HP:0100654)3.60890266
19Poor head control (HP:0002421)3.57231005
20Abnormality of monocarboxylic acid metabolism (HP:0010996)3.51237797
21Abolished electroretinogram (ERG) (HP:0000550)3.49761108
22Decreased electroretinogram (ERG) amplitude (HP:0000654)3.42936138
23Orchitis (HP:0100796)3.37038456
24Amyloidosis (HP:0011034)3.35793804
25Recurrent abscess formation (HP:0002722)3.34265762
26Abnormal spermatogenesis (HP:0008669)3.24452976
27Increased serum ferritin (HP:0003281)3.23215545
28Chronic diarrhea (HP:0002028)3.22005425
29Prolonged partial thromboplastin time (HP:0003645)3.18532909
30Recurrent bacterial skin infections (HP:0005406)3.14922614
31Intrahepatic cholestasis (HP:0001406)3.03857853
32Abnormality of iron homeostasis (HP:0011031)3.01850728
33Xanthomatosis (HP:0000991)2.98370695
34Chronic otitis media (HP:0000389)2.97527903
35Recurrent gram-negative bacterial infections (HP:0005420)2.97426915
36Pulmonary infiltrates (HP:0002113)2.95737419
37Glycosuria (HP:0003076)2.93000369
38Abnormality of urine glucose concentration (HP:0011016)2.93000369
39Hyperglycinuria (HP:0003108)2.92775603
40Hepatocellular carcinoma (HP:0001402)2.91410033
41Gangrene (HP:0100758)2.91234679
42Complement deficiency (HP:0004431)2.89212074
43Malnutrition (HP:0004395)2.86712437
44Xerostomia (HP:0000217)2.84142575
45Eczematoid dermatitis (HP:0000976)2.84119409
46Alkalosis (HP:0001948)2.84030103
47Abnormal glucose tolerance (HP:0001952)2.82779204
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82644323
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81004856
50Keratoconjunctivitis (HP:0001096)2.80187718
51Deep venous thrombosis (HP:0002625)2.77199946
52Systemic lupus erythematosus (HP:0002725)2.72799561
53* Skin rash (HP:0000988)2.71940671
54Keratoconjunctivitis sicca (HP:0001097)2.71106673
55Fat malabsorption (HP:0002630)2.70777377
56Abnormality of vitamin B metabolism (HP:0004340)2.68990870
57Decreased circulating renin level (HP:0003351)2.68444924
58* Abnormality of the pleura (HP:0002103)2.67921249
59Abnormality of serine family amino acid metabolism (HP:0010894)2.67856300
60Abnormality of glycine metabolism (HP:0010895)2.67856300
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.66998207
62Abnormality of transition element cation homeostasis (HP:0011030)2.64443324
63Absent/shortened dynein arms (HP:0200106)2.64028099
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.64028099
65* Nephritis (HP:0000123)2.62819543
66Exertional dyspnea (HP:0002875)2.61882377
67Erythema (HP:0010783)2.60419873
68Hyperlipoproteinemia (HP:0010980)2.60169542
69Recurrent sinusitis (HP:0011108)2.59199453
70Pustule (HP:0200039)2.53409824
71Peritonitis (HP:0002586)2.52008738
72Metabolic alkalosis (HP:0200114)2.46129078
73Glomerulonephritis (HP:0000099)2.46090474
74Abnormality of vitamin metabolism (HP:0100508)2.45262723
75Congenital sensorineural hearing impairment (HP:0008527)2.42432338
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40273976
77* Abnormality of complement system (HP:0005339)2.37164450
78Arterial thrombosis (HP:0004420)2.35008098
79Joint hemorrhage (HP:0005261)2.34453216
80Abnormality of pyrimidine metabolism (HP:0004353)2.33851614
81Pancreatitis (HP:0001733)2.30844501
82Cardiomegaly (HP:0001640)2.30134470
83Mediastinal lymphadenopathy (HP:0100721)2.29078727
84Macular degeneration (HP:0000608)2.28078170
85Pulmonary fibrosis (HP:0002206)2.27025048
86Recurrent skin infections (HP:0001581)2.24347052
87Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23006582
88* Vasculitis (HP:0002633)2.21277551
89Increased hepatocellular lipid droplets (HP:0006565)2.17886643
90Pigmentary retinal degeneration (HP:0001146)2.17635937
91Hypoproteinemia (HP:0003075)2.16874534
92Dicarboxylic aciduria (HP:0003215)2.16102610
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16102610
94Gingival bleeding (HP:0000225)2.16101440
95Epidermoid cyst (HP:0200040)2.15916894
96Pulmonary embolism (HP:0002204)2.15632027
97Anorexia (HP:0002039)2.15510543
98Renal Fanconi syndrome (HP:0001994)2.15182015
99* Meningitis (HP:0001287)2.11920968
100Abnormality of the axillary hair (HP:0100134)2.11733444
101Abnormality of secondary sexual hair (HP:0009888)2.11733444
102Potter facies (HP:0002009)2.11286606
103Facial shape deformation (HP:0011334)2.11286606
104Generalized aminoaciduria (HP:0002909)2.07896613
105Lethargy (HP:0001254)2.07763735
106* Obstructive lung disease (HP:0006536)2.07714795
107* Chronic obstructive pulmonary disease (HP:0006510)2.07714795
108Progressive microcephaly (HP:0000253)2.07354120
109Aplastic anemia (HP:0001915)2.07271928
110Generalized hyperpigmentation (HP:0007440)2.07054863
111Hyperphosphaturia (HP:0003109)2.06713085
112Lipid accumulation in hepatocytes (HP:0006561)2.06413719
113Myocardial infarction (HP:0001658)2.06221549
114Mucosal telangiectasiae (HP:0100579)2.06081207
115Hyperammonemia (HP:0001987)2.05774544
116Progressive visual loss (HP:0000529)2.05090046
117Conjugated hyperbilirubinemia (HP:0002908)2.04570976
118Erythroderma (HP:0001019)2.03715190
119Hepatic necrosis (HP:0002605)2.03697584
120Acute encephalopathy (HP:0006846)2.00380967
121Abnormality of macrophages (HP:0004311)2.00268235
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99517773
123Metabolic acidosis (HP:0001942)1.99293648
124Hepatocellular necrosis (HP:0001404)1.98669469
125Thrombophlebitis (HP:0004418)1.98154393
126Hyperbilirubinemia (HP:0002904)1.97797813
127Delayed CNS myelination (HP:0002188)1.97699730
128Abnormality of B cell number (HP:0010975)1.97692434
129Steatorrhea (HP:0002570)1.97479700
130Interstitial pulmonary disease (HP:0006530)1.97366963
131Abnormality of renin-angiotensin system (HP:0000847)1.97127116
132Spontaneous abortion (HP:0005268)1.96914049
133Hyperventilation (HP:0002883)1.95967313
134Cerebral edema (HP:0002181)1.95193682
135Oral leukoplakia (HP:0002745)1.94625290
136Ileus (HP:0002595)1.93909904
137Chin dimple (HP:0010751)1.92800556
138Mitral stenosis (HP:0001718)1.92273336
139Acute necrotizing encephalopathy (HP:0006965)1.91966482
140Nausea (HP:0002018)1.91581967
141* Hemoptysis (HP:0002105)1.90809194
142Abnormality of sulfur amino acid metabolism (HP:0004339)1.90148284
143Confusion (HP:0001289)1.90082132
144Congenital stationary night blindness (HP:0007642)1.89651498
145Abnormality of the prostate (HP:0008775)1.88992339
146Joint swelling (HP:0001386)1.88355649
147Mitochondrial inheritance (HP:0001427)1.87986914
148Abnormality of nucleobase metabolism (HP:0010932)1.87506006
149Urticaria (HP:0001025)1.87387284
150Widely patent fontanelles and sutures (HP:0004492)1.86872253
151Abnormality of methionine metabolism (HP:0010901)1.86223426
152Recurrent bronchitis (HP:0002837)1.86174573
153Abnormality of male internal genitalia (HP:0000022)1.83968199
154Encephalitis (HP:0002383)1.83762691
155Vacuolated lymphocytes (HP:0001922)1.83614319
156* Acrocyanosis (HP:0001063)1.83574984
157Hypobetalipoproteinemia (HP:0003563)1.83245755
158Pancreatic cysts (HP:0001737)1.83082866
159Hypolipoproteinemia (HP:0010981)1.83048562
160Abnormality of serum amino acid levels (HP:0003112)1.82271400
161Fair hair (HP:0002286)1.81888034
162Megaloblastic anemia (HP:0001889)1.81430866
163Irritability (HP:0000737)1.79314787
164Agammaglobulinemia (HP:0004432)1.79086474
165Ureteral stenosis (HP:0000071)1.78001404
166Methylmalonic aciduria (HP:0012120)1.77254890
167Acanthocytosis (HP:0001927)1.76862927
168Hyperactive renin-angiotensin system (HP:0000841)1.75401124
169Gastrointestinal stroma tumor (HP:0100723)1.73647696

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.17922262
2BLK4.92393852
3FRK4.37319249
4ACVR1B4.22610258
5MST43.96531537
6MAP3K143.60264509
7TAOK23.23298547
8TXK3.17384737
9MAP3K123.15574715
10TBK12.94540258
11NUAK12.40324426
12CSF1R2.38805983
13OXSR12.36191266
14BMPR1B2.27909994
15TYK22.22326543
16CSK2.11647654
17MAP4K22.08842180
18IRAK42.07366705
19IRAK32.06715577
20TLK12.03295270
21EPHA32.02579245
22RIPK41.88395897
23IKBKB1.84326419
24MAP3K131.73269002
25WNK31.73105876
26FGFR41.69841990
27SCYL21.67614464
28SYK1.66522584
29TEC1.59866514
30INSRR1.56860504
31KIT1.51002216
32PIK3CA1.50858189
33PRKG21.48834803
34MAP2K61.47907826
35BMPR21.41593741
36STK391.41173930
37STK241.40652864
38MAPK131.39736272
39MAPKAPK31.33554831
40GRK11.29120605
41PKN11.27548993
42TGFBR21.27308166
43TIE11.26233067
44LYN1.22783545
45IKBKE1.17828778
46RIPK11.13604459
47JAK11.12077159
48ERN11.09317496
49MAP3K51.09073882
50ZAP701.08542201
51CDK191.06941823
52EPHB11.05629179
53JAK31.05628573
54ITK1.03162598
55PTK2B1.00099526
56TAOK30.99435086
57NEK90.96755953
58ARAF0.95758861
59MYLK0.95503453
60BTK0.95459717
61DAPK20.93850435
62HCK0.92292939
63PDK10.88044457
64FES0.87976155
65FER0.85572761
66MAP3K110.82622976
67FLT30.82039845
68PRKCE0.81615705
69PRKACG0.79547649
70LRRK20.77080334
71MAP3K60.76438238
72MAP3K20.76275189
73JAK20.75651577
74DYRK1B0.74288848
75IRAK10.73374395
76ERBB20.73223538
77MAP3K40.72176478
78WNK40.69936158
79LCK0.68259628
80GRK60.68200270
81EIF2AK20.67363541
82ZAK0.66992535
83NLK0.64367608
84PRKCD0.64137330
85PIM20.63680531
86KDR0.62680575
87PRKCA0.62378035
88STK38L0.61778842
89MAP2K30.60599615
90CLK10.60516451
91PAK30.60074653
92PDPK10.60024559
93PRKACA0.59913457
94RPS6KA50.59182584
95PRKCZ0.58865480
96MAP3K80.57778001
97FGFR30.57514377
98MUSK0.56785367
99PIM10.56473134
100PIK3CG0.55831807
101ADRBK10.55710125
102TRIM280.55191597
103DAPK10.54464407
104CSNK1A10.54082061
105FGR0.52341333
106SGK30.51452890
107BCKDK0.51180841
108CAMK2D0.49677549
109SGK20.49095582
110MATK0.46894608
111EPHB20.46662709
112MST1R0.45190846
113MAP3K90.44632411
114RAF10.44293454
115ILK0.42824076
116STK110.42744719
117PRKG10.41944993
118MAPK110.41931134
119MAP3K30.41585364
120CSNK1A1L0.41006525
121DAPK30.41003326
122PRKCQ0.40420538
123TNK20.40410699
124EIF2AK10.39545128
125EIF2AK30.39039484
126TNIK0.38238521
127CAMK2A0.38111787
128ADRBK20.38088079
129MAPK70.37733991
130MAP3K10.37401927
131OBSCN0.37261643
132GRK70.36479137
133HIPK20.36252660
134CASK0.36249934
135RPS6KA60.34688073
136PINK10.33734838
137STK160.32022726
138PTK60.31536096
139RPS6KC10.30965009
140RPS6KL10.30965009
141PRKAA20.29901101
142CHUK0.29261281
143ABL10.27231039
144IGF1R0.23574740
145ABL20.23388941
146PAK40.22306914
147MAPK40.21899600
148STK100.19717124

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.25713193
2Asthma_Homo sapiens_hsa053104.15393332
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.85276765
4Autoimmune thyroid disease_Homo sapiens_hsa053203.24041185
5Staphylococcus aureus infection_Homo sapiens_hsa051503.18707229
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.85310923
7Complement and coagulation cascades_Homo sapiens_hsa046102.82936531
8Type I diabetes mellitus_Homo sapiens_hsa049402.80676616
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77153121
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.74762177
11Histidine metabolism_Homo sapiens_hsa003402.56936242
12Fatty acid metabolism_Homo sapiens_hsa012122.50990448
13Arginine biosynthesis_Homo sapiens_hsa002202.25424715
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16336023
15Phenylalanine metabolism_Homo sapiens_hsa003602.11837865
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04454738
17Tryptophan metabolism_Homo sapiens_hsa003801.95609110
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85525847
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81876881
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.80964696
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78338928
22Chemical carcinogenesis_Homo sapiens_hsa052041.72274439
23Fatty acid degradation_Homo sapiens_hsa000711.70986715
24beta-Alanine metabolism_Homo sapiens_hsa004101.67939444
25Retinol metabolism_Homo sapiens_hsa008301.62782721
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.60734504
27Viral myocarditis_Homo sapiens_hsa054161.52957444
28Peroxisome_Homo sapiens_hsa041461.52636579
29ABC transporters_Homo sapiens_hsa020101.50264186
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.47830088
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.42881116
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40585241
33Lysosome_Homo sapiens_hsa041421.39467587
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37076346
35PPAR signaling pathway_Homo sapiens_hsa033201.36369649
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.35703573
37Tyrosine metabolism_Homo sapiens_hsa003501.32561780
38Rheumatoid arthritis_Homo sapiens_hsa053231.32025454
39Nitrogen metabolism_Homo sapiens_hsa009101.30687389
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27684737
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18917985
42Primary immunodeficiency_Homo sapiens_hsa053401.15452638
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.15385429
44One carbon pool by folate_Homo sapiens_hsa006701.12876744
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12472719
46Vitamin digestion and absorption_Homo sapiens_hsa049771.11648345
47Starch and sucrose metabolism_Homo sapiens_hsa005001.11092014
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.06042461
49Leishmaniasis_Homo sapiens_hsa051401.03768567
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00419462
51Renin-angiotensin system_Homo sapiens_hsa046140.98666684
52Antigen processing and presentation_Homo sapiens_hsa046120.98532558
53Osteoclast differentiation_Homo sapiens_hsa043800.97531333
54Mineral absorption_Homo sapiens_hsa049780.93696180
55Systemic lupus erythematosus_Homo sapiens_hsa053220.93696024
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89335551
57B cell receptor signaling pathway_Homo sapiens_hsa046620.86841207
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.85439707
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83531423
60Chemokine signaling pathway_Homo sapiens_hsa040620.82512271
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81287198
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79904166
63Arachidonic acid metabolism_Homo sapiens_hsa005900.79644951
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78618648
65Butanoate metabolism_Homo sapiens_hsa006500.77190217
66Influenza A_Homo sapiens_hsa051640.76617351
67Salmonella infection_Homo sapiens_hsa051320.75074355
68Pertussis_Homo sapiens_hsa051330.74633064
69Caffeine metabolism_Homo sapiens_hsa002320.74356834
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73447158
71Oxidative phosphorylation_Homo sapiens_hsa001900.72271310
72Protein export_Homo sapiens_hsa030600.71971777
73Glycerolipid metabolism_Homo sapiens_hsa005610.68868598
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67352782
75Other glycan degradation_Homo sapiens_hsa005110.63707584
76Legionellosis_Homo sapiens_hsa051340.63666332
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63370880
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62091327
79Allograft rejection_Homo sapiens_hsa053300.62084278
80African trypanosomiasis_Homo sapiens_hsa051430.61839180
81Herpes simplex infection_Homo sapiens_hsa051680.58838877
82Linoleic acid metabolism_Homo sapiens_hsa005910.58483358
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57659912
84Bile secretion_Homo sapiens_hsa049760.54731016
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53701722
86Propanoate metabolism_Homo sapiens_hsa006400.52471688
87Measles_Homo sapiens_hsa051620.52395246
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51943996
89Phagosome_Homo sapiens_hsa041450.51461093
90Fat digestion and absorption_Homo sapiens_hsa049750.50240395
91Ether lipid metabolism_Homo sapiens_hsa005650.50194543
92Hematopoietic cell lineage_Homo sapiens_hsa046400.49893416
93Tuberculosis_Homo sapiens_hsa051520.47870933
94Graft-versus-host disease_Homo sapiens_hsa053320.45587149
95Malaria_Homo sapiens_hsa051440.43708280
96Arginine and proline metabolism_Homo sapiens_hsa003300.42866000
97Parkinsons disease_Homo sapiens_hsa050120.41751325
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41013344
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40428773
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38400878
101Pentose phosphate pathway_Homo sapiens_hsa000300.38370944
102TNF signaling pathway_Homo sapiens_hsa046680.37863920
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.37630372
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36867679
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35631528
106Sulfur metabolism_Homo sapiens_hsa009200.35559209
107Hepatitis C_Homo sapiens_hsa051600.33764035
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33597672
109Fatty acid biosynthesis_Homo sapiens_hsa000610.32897869
110Protein digestion and absorption_Homo sapiens_hsa049740.32432405
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31492433
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29568065
113Apoptosis_Homo sapiens_hsa042100.29187020
114Toxoplasmosis_Homo sapiens_hsa051450.28520538
115Ribosome_Homo sapiens_hsa030100.27407013
116Glutathione metabolism_Homo sapiens_hsa004800.25457903
117Metabolic pathways_Homo sapiens_hsa011000.25293787
118Regulation of autophagy_Homo sapiens_hsa041400.25016790
119Folate biosynthesis_Homo sapiens_hsa007900.23453266
120Biosynthesis of amino acids_Homo sapiens_hsa012300.22850637
121Phototransduction_Homo sapiens_hsa047440.22613014
122Selenocompound metabolism_Homo sapiens_hsa004500.21436571
123Fructose and mannose metabolism_Homo sapiens_hsa000510.21409115
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18710916
125Prion diseases_Homo sapiens_hsa050200.18335169
126Alzheimers disease_Homo sapiens_hsa050100.17047715
127Pancreatic secretion_Homo sapiens_hsa049720.14461088
128Cysteine and methionine metabolism_Homo sapiens_hsa002700.14103315
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14075325
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.13126803
131Pyruvate metabolism_Homo sapiens_hsa006200.12944406
132Collecting duct acid secretion_Homo sapiens_hsa049660.12583580

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