DNAJC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.74447457
2Golgi transport vesicle coating (GO:0048200)6.74447457
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.95746026
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.57492804
5L-phenylalanine catabolic process (GO:0006559)5.57492804
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.29052669
7L-phenylalanine metabolic process (GO:0006558)5.29052669
8protein retention in ER lumen (GO:0006621)5.18546723
9COPII vesicle coating (GO:0048208)4.99094867
10lactate metabolic process (GO:0006089)4.86943162
11positive regulation of protein autophosphorylation (GO:0031954)4.72496342
12aromatic amino acid family catabolic process (GO:0009074)4.57281066
13sulfur amino acid catabolic process (GO:0000098)4.47955013
14cysteine metabolic process (GO:0006534)4.46956863
15intestinal cholesterol absorption (GO:0030299)4.32689708
16protein carboxylation (GO:0018214)4.29726268
17peptidyl-glutamic acid carboxylation (GO:0017187)4.29726268
18regulation of glucokinase activity (GO:0033131)4.20607346
19regulation of hexokinase activity (GO:1903299)4.20607346
20valine metabolic process (GO:0006573)4.19335134
21exocrine pancreas development (GO:0031017)4.16566353
22* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.12969992
23ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07487166
24water-soluble vitamin biosynthetic process (GO:0042364)4.06123365
25alpha-linolenic acid metabolic process (GO:0036109)4.04644646
26regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.02722521
274-hydroxyproline metabolic process (GO:0019471)3.97738662
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.95508860
29* positive regulation of nuclease activity (GO:0032075)3.93080034
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92039956
31complement activation, alternative pathway (GO:0006957)3.91635739
32homocysteine metabolic process (GO:0050667)3.87638694
33tryptophan metabolic process (GO:0006568)3.85857681
34cellular ketone body metabolic process (GO:0046950)3.85217336
35bile acid biosynthetic process (GO:0006699)3.79866599
36proteasome assembly (GO:0043248)3.79387677
37high-density lipoprotein particle remodeling (GO:0034375)3.79277838
38positive regulation of glycolytic process (GO:0045821)3.78033310
39ketone body metabolic process (GO:1902224)3.77943118
40tryptophan catabolic process (GO:0006569)3.77934085
41indole-containing compound catabolic process (GO:0042436)3.77934085
42indolalkylamine catabolic process (GO:0046218)3.77934085
43regulation of type B pancreatic cell apoptotic process (GO:2000674)3.74933285
44signal peptide processing (GO:0006465)3.74900451
45regulation of protein activation cascade (GO:2000257)3.74581087
46glyoxylate metabolic process (GO:0046487)3.74484823
47kynurenine metabolic process (GO:0070189)3.74444778
48cellular modified amino acid catabolic process (GO:0042219)3.74388621
49negative regulation of fibrinolysis (GO:0051918)3.72617065
50lysine catabolic process (GO:0006554)3.71748951
51lysine metabolic process (GO:0006553)3.71748951
52urea metabolic process (GO:0019627)3.70253250
53urea cycle (GO:0000050)3.70253250
54* endoplasmic reticulum unfolded protein response (GO:0030968)3.70237851
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.65932778
56reverse cholesterol transport (GO:0043691)3.65264910
57positive regulation of glycoprotein biosynthetic process (GO:0010560)3.64630035
58keratinocyte development (GO:0003334)3.63714130
59UDP-N-acetylglucosamine metabolic process (GO:0006047)3.60431711
60* cellular response to unfolded protein (GO:0034620)3.59570058
61regulation of complement activation (GO:0030449)3.56943960
62* regulation of nuclease activity (GO:0032069)3.54491930
63regulation of fibrinolysis (GO:0051917)3.53105320
64* ER-nucleus signaling pathway (GO:0006984)3.50059492
65negative regulation of acute inflammatory response (GO:0002674)3.47666535
66tyrosine metabolic process (GO:0006570)3.47355136
67bile acid metabolic process (GO:0008206)3.42230065
68zinc ion transport (GO:0006829)3.40885792
69nitrogen cycle metabolic process (GO:0071941)3.40211306
70regulation of protein autophosphorylation (GO:0031952)3.40202973
71respiratory chain complex IV assembly (GO:0008535)3.39870155
72aromatic amino acid family metabolic process (GO:0009072)3.38620842
73* cellular response to topologically incorrect protein (GO:0035967)3.38026360
74transcytosis (GO:0045056)3.37461088
75sequestering of metal ion (GO:0051238)3.37262268
76negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.35669619
77drug transmembrane transport (GO:0006855)3.34619378
78platelet dense granule organization (GO:0060155)3.34487062
79regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.33029375
80regulation of cholesterol homeostasis (GO:2000188)3.31789580
81regulation of protein glycosylation (GO:0060049)3.29484523
82regulation of meiosis I (GO:0060631)3.25712480
83plasma lipoprotein particle remodeling (GO:0034369)3.25104958
84protein-lipid complex remodeling (GO:0034368)3.25104958
85macromolecular complex remodeling (GO:0034367)3.25104958
86serine family amino acid catabolic process (GO:0009071)3.23734880
87bile acid and bile salt transport (GO:0015721)3.23607680
88endocrine pancreas development (GO:0031018)3.23023750
89vesicle coating (GO:0006901)3.22739947
90regulation of triglyceride catabolic process (GO:0010896)3.21679724
91* response to endoplasmic reticulum stress (GO:0034976)3.18031867
92acylglycerol homeostasis (GO:0055090)3.17083264
93triglyceride homeostasis (GO:0070328)3.17083264
94inositol phosphate catabolic process (GO:0071545)3.16864379
95intestinal absorption (GO:0050892)3.15794380
96hormone catabolic process (GO:0042447)3.15227877
97alpha-amino acid catabolic process (GO:1901606)3.14839916
98coenzyme catabolic process (GO:0009109)3.12853105
99cellular amino acid catabolic process (GO:0009063)3.10643937
100positive regulation of glycoprotein metabolic process (GO:1903020)3.10482865
101phospholipid efflux (GO:0033700)3.10453730
1022-oxoglutarate metabolic process (GO:0006103)3.10128046
103negative regulation of protein autophosphorylation (GO:0031953)3.10024194
104negative regulation of cholesterol transport (GO:0032375)3.09041462
105negative regulation of sterol transport (GO:0032372)3.09041462
106positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07886458
107negative regulation of neurological system process (GO:0031645)3.05533645
108amino-acid betaine metabolic process (GO:0006577)3.03804381
109dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.01802033
110nucleotide transmembrane transport (GO:1901679)3.00648921
111protein N-linked glycosylation via asparagine (GO:0018279)3.00186459
112phosphorylated carbohydrate dephosphorylation (GO:0046838)2.99520197
113inositol phosphate dephosphorylation (GO:0046855)2.99520197
114short-chain fatty acid metabolic process (GO:0046459)2.98479615
115peptidyl-asparagine modification (GO:0018196)2.98273884
116indolalkylamine metabolic process (GO:0006586)2.97140220
117lipoprotein metabolic process (GO:0042157)2.94041881
118positive regulation of actin filament depolymerization (GO:0030836)2.92434949
119cytochrome complex assembly (GO:0017004)2.92310071
120xenobiotic catabolic process (GO:0042178)2.91761584
121ER overload response (GO:0006983)2.91514120
122plasma lipoprotein particle clearance (GO:0034381)2.90576176
123cholesterol efflux (GO:0033344)2.90319363
124response to pheromone (GO:0019236)2.90219301
125branched-chain amino acid metabolic process (GO:0009081)2.90127229
126complement activation, classical pathway (GO:0006958)2.90037545
127protein maturation by protein folding (GO:0022417)2.89972821
128fatty acid oxidation (GO:0019395)2.89089728
129ethanol oxidation (GO:0006069)2.86142325
130tricarboxylic acid metabolic process (GO:0072350)2.84817817
131fatty acid beta-oxidation (GO:0006635)2.84224924
132peptide hormone processing (GO:0016486)2.84180189
133lipid oxidation (GO:0034440)2.83185091
134polyol catabolic process (GO:0046174)2.81917069
135glutamate metabolic process (GO:0006536)2.80624458
136ER to Golgi vesicle-mediated transport (GO:0006888)2.78764615
137regulation of B cell apoptotic process (GO:0002902)2.78023195
138cullin deneddylation (GO:0010388)2.75489343
139inositol phosphate-mediated signaling (GO:0048016)2.75336557
140intestinal epithelial cell development (GO:0060576)2.75253613
141positive regulation of meiosis (GO:0045836)2.73136440
142regulation of acrosome reaction (GO:0060046)2.71393560
143positive regulation of respiratory burst (GO:0060267)2.67557902
144nucleotide-sugar biosynthetic process (GO:0009226)2.65613775
145negative regulation of complement activation (GO:0045916)2.61646469
146branched-chain amino acid catabolic process (GO:0009083)2.59668225
147positive regulation of meiotic cell cycle (GO:0051446)2.55856743
148protein deneddylation (GO:0000338)2.55790215
149sphingosine metabolic process (GO:0006670)2.55732843
150nitric oxide mediated signal transduction (GO:0007263)2.55037773
151positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.53396460
152positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.53396460
153positive regulation of mitotic sister chromatid separation (GO:1901970)2.53396460
154negative regulation of protein activation cascade (GO:2000258)2.51991535
155eosinophil chemotaxis (GO:0048245)2.51288829
156nucleotide-sugar metabolic process (GO:0009225)2.50638346
157prenylation (GO:0097354)2.50531647
158protein prenylation (GO:0018342)2.50531647
159regulation of cytokine secretion involved in immune response (GO:0002739)2.50478080
160kidney morphogenesis (GO:0060993)2.46605015
161positive regulation of calcium ion import (GO:0090280)2.43671195
162regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43335311
163parental behavior (GO:0060746)2.43133650
164S-adenosylmethionine metabolic process (GO:0046500)2.42548911
165endosome to pigment granule transport (GO:0043485)2.41719846
166endosome to melanosome transport (GO:0035646)2.41719846
167synapsis (GO:0007129)2.41303956
168protein K11-linked deubiquitination (GO:0035871)2.41167218
169mannosylation (GO:0097502)2.41112924
170negative regulation of protein oligomerization (GO:0032460)2.40966102
171positive regulation of macroautophagy (GO:0016239)2.39471719
172nitric oxide biosynthetic process (GO:0006809)2.39409346
173response to hydroperoxide (GO:0033194)2.37844795
174insulin secretion (GO:0030073)2.37315642
175protein K6-linked ubiquitination (GO:0085020)2.36895917
176regulation of Rac protein signal transduction (GO:0035020)2.36590438
177C-terminal protein lipidation (GO:0006501)2.36117199
178keratan sulfate catabolic process (GO:0042340)2.35793821
179DNA deamination (GO:0045006)2.35265508
180sphingoid metabolic process (GO:0046519)2.35170831
181early endosome to late endosome transport (GO:0045022)2.32233963
182negative regulation of execution phase of apoptosis (GO:1900118)2.32091722
183prostate gland growth (GO:0060736)2.30387607
184negative regulation of JUN kinase activity (GO:0043508)2.29994159
185fucose catabolic process (GO:0019317)2.29929258
186L-fucose metabolic process (GO:0042354)2.29929258
187L-fucose catabolic process (GO:0042355)2.29929258
188developmental pigmentation (GO:0048066)2.29559348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.44335303
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.12568980
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.39175484
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.11281685
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.53044273
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.20345969
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.69151603
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.53630138
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46552636
10GATA1_22025678_ChIP-Seq_K562_Human3.41375977
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09472146
12CLOCK_20551151_ChIP-Seq_293T_Human2.77709581
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.72400646
14* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62443627
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.46681936
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.33585854
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27887613
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27837356
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25061768
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.21164106
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.12883178
22* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12385763
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12236730
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09819571
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.01958380
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98697785
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.98189558
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97593048
29ZNF274_21170338_ChIP-Seq_K562_Hela1.96935677
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.94923059
31VDR_22108803_ChIP-Seq_LS180_Human1.92991846
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89622940
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.88657510
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88095696
35* ELK1_19687146_ChIP-ChIP_HELA_Human1.87511202
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.84714863
37FOXA2_19822575_ChIP-Seq_HepG2_Human1.77311227
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70382644
39P300_19829295_ChIP-Seq_ESCs_Human1.69129740
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.68058110
41BCAT_22108803_ChIP-Seq_LS180_Human1.66338761
42AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57841254
43FUS_26573619_Chip-Seq_HEK293_Human1.56678534
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.56596734
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.56386899
46ER_23166858_ChIP-Seq_MCF-7_Human1.56331376
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.55179497
48GBX2_23144817_ChIP-Seq_PC3_Human1.54265716
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.53534546
50FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53109443
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53081191
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.52589496
53NANOG_18555785_Chip-Seq_ESCs_Mouse1.51372261
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50463397
55EWS_26573619_Chip-Seq_HEK293_Human1.48094469
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46810970
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46294414
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.46254753
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45630463
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45535105
61P53_22387025_ChIP-Seq_ESCs_Mouse1.43011775
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.42479051
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42373239
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41598559
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41087191
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.41024331
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40977633
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38769882
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37184597
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36748047
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.36338643
72SMAD4_21799915_ChIP-Seq_A2780_Human1.36302066
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36073929
74P300_18555785_Chip-Seq_ESCs_Mouse1.35622688
75OCT4_21477851_ChIP-Seq_ESCs_Mouse1.35453751
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.35200621
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35019579
78SOX2_20726797_ChIP-Seq_SW620_Human1.34679104
79SOX2_19829295_ChIP-Seq_ESCs_Human1.34354863
80NANOG_19829295_ChIP-Seq_ESCs_Human1.34354863
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.33353017
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.33218375
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32861585
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32548571
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32361794
86SOX2_18555785_Chip-Seq_ESCs_Mouse1.31721407
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30708045
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28608091
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28369579
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26830184
91TCF4_22108803_ChIP-Seq_LS180_Human1.25617143
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25496819
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23841979
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.23652211
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.22752437
96* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22723726
97* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22101892
98* CBP_20019798_ChIP-Seq_JUKART_Human1.22101892
99* AR_25329375_ChIP-Seq_VCAP_Human1.21871502
100HNF4A_19822575_ChIP-Seq_HepG2_Human1.21867552
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20911530
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20674162
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19405135
104FOXA1_25552417_ChIP-Seq_VCAP_Human1.19364836
105* GATA6_25053715_ChIP-Seq_YYC3_Human1.19009438
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18361218
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18308910
108TAF15_26573619_Chip-Seq_HEK293_Human1.17093865
109CTCF_18555785_Chip-Seq_ESCs_Mouse1.16856339
110BRD4_25478319_ChIP-Seq_HGPS_Human1.16633233
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16525279
112VDR_23849224_ChIP-Seq_CD4+_Human1.16083876
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.15996200
114SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14945148
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.14870025
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.13801356
117STAT3_23295773_ChIP-Seq_U87_Human1.13125975
118IGF1R_20145208_ChIP-Seq_DFB_Human1.12976208
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.12863889
120PU1_27457419_Chip-Seq_LIVER_Mouse1.12568722
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11892865
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11434348
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11222614
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11164191
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10930000
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10216045
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.09987327
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09987327
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.09649157
130SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09077691
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08909529
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07585080
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06402582
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04692437
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02404547
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02404547
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02095373
138IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01361090
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99698558
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99185804
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97573730
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96690767
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.94647005
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94105022
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93586447
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92333979
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90588554
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89578769
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87480716
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86614318
151* TBX20_22080862_ChIP-Seq_HEART_Mouse0.86453796
152* TBX20_22328084_ChIP-Seq_HEART_Mouse0.86453796
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85302139
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82864187
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82017031
156ERG_20517297_ChIP-Seq_VCAP_Human0.81472931
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80785751
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80684070
159GATA1_19941826_ChIP-Seq_K562_Human0.80111976
160ESR1_20079471_ChIP-ChIP_T-47D_Human0.78998724
161TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78631590
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.78126072
163CHD1_26751641_Chip-Seq_LNCaP_Human0.76962098
164KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76382751
165TP63_17297297_ChIP-ChIP_HaCaT_Human0.76239788
166MYB_21317192_ChIP-Seq_ERMYB_Mouse0.74812072
167GATA3_27048872_Chip-Seq_THYMUS_Human0.74539953
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72781858
169GATA2_19941826_ChIP-Seq_K562_Human0.72601496
170SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71270955
171TP63_23658742_ChIP-Seq_EP156T_Human0.71085229
172CJUN_26792858_Chip-Seq_BT549_Human0.69982733
173PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68725364
174ZNF263_19887448_ChIP-Seq_K562_Human0.67928023
175* IRF8_27001747_Chip-Seq_BMDM_Mouse0.67118515
176HTT_18923047_ChIP-ChIP_STHdh_Human0.66145415
177* RACK7_27058665_Chip-Seq_MCF-7_Human0.66032278
178AR_20517297_ChIP-Seq_VCAP_Human0.65448975
179TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.65380072
180ATF3_27146783_Chip-Seq_COLON_Human0.65016589
181RUNX1_27514584_Chip-Seq_MCF-7_Human0.63493252
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.62109413
183SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61418604
184* CDX2_22108803_ChIP-Seq_LS180_Human0.60898473
185LXR_22292898_ChIP-Seq_THP-1_Human0.60816711
186CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.60483292
187GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.60070471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.72692202
2MP0005365_abnormal_bile_salt5.03550965
3MP0005360_urolithiasis4.62725130
4MP0005085_abnormal_gallbladder_physiolo4.22700605
5MP0003252_abnormal_bile_duct3.41771530
6MP0001666_abnormal_nutrient_absorption3.25384019
7MP0008875_abnormal_xenobiotic_pharmacok3.09633257
8MP0003195_calcinosis2.93442910
9MP0005083_abnormal_biliary_tract2.89489349
10MP0000372_irregular_coat_pigmentation2.84252246
11MP0002837_dystrophic_cardiac_calcinosis2.80962068
12MP0003950_abnormal_plasma_membrane2.72748235
13MP0005220_abnormal_exocrine_pancreas2.65377667
14MP0010329_abnormal_lipoprotein_level2.46400320
15MP0003300_gastrointestinal_ulcer2.37934721
16MP0002163_abnormal_gland_morphology2.33369482
17MP0003868_abnormal_feces_composition2.31855630
18MP0008877_abnormal_DNA_methylation2.23364743
19MP0005332_abnormal_amino_acid2.19788419
20MP0003806_abnormal_nucleotide_metabolis2.16647160
21MP0002138_abnormal_hepatobiliary_system2.06530958
22MP0009840_abnormal_foam_cell2.06264641
23MP0002877_abnormal_melanocyte_morpholog2.04411785
24MP0010352_gastrointestinal_tract_polyps2.02644268
25MP0005174_abnormal_tail_pigmentation1.98230551
26MP0004043_abnormal_pH_regulation1.96775473
27MP0002693_abnormal_pancreas_physiology1.89459544
28* MP0009643_abnormal_urine_homeostasis1.83722091
29MP0005075_abnormal_melanosome_morpholog1.82213537
30MP0009780_abnormal_chondrocyte_physiolo1.81977916
31MP0000609_abnormal_liver_physiology1.81115439
32* MP0001944_abnormal_pancreas_morphology1.80182005
33MP0000569_abnormal_digit_pigmentation1.79965840
34MP0003191_abnormal_cellular_cholesterol1.75667651
35MP0004264_abnormal_extraembryonic_tissu1.75552735
36MP0002118_abnormal_lipid_homeostasis1.73842666
37MP0000516_abnormal_urinary_system1.72865177
38MP0005367_renal/urinary_system_phenotyp1.72865177
39MP0010234_abnormal_vibrissa_follicle1.72614960
40MP0010678_abnormal_skin_adnexa1.71777923
41MP0005058_abnormal_lysosome_morphology1.70899845
42MP0000015_abnormal_ear_pigmentation1.66029367
43MP0003705_abnormal_hypodermis_morpholog1.65822635
44MP0003787_abnormal_imprinting1.59451056
45MP0003183_abnormal_peptide_metabolism1.54366497
46MP0002938_white_spotting1.51911779
47MP0005319_abnormal_enzyme/_coenzyme1.44579920
48MP0008438_abnormal_cutaneous_collagen1.44477676
49MP0006072_abnormal_retinal_apoptosis1.42428747
50MP0003011_delayed_dark_adaptation1.41617664
51MP0002909_abnormal_adrenal_gland1.40242410
52MP0002090_abnormal_vision1.39626155
53MP0006054_spinal_hemorrhage1.38103851
54MP0001756_abnormal_urination1.37641056
55* MP0002078_abnormal_glucose_homeostasis1.36728660
56MP0000427_abnormal_hair_cycle1.35817087
57MP0004019_abnormal_vitamin_homeostasis1.35601750
58MP0005636_abnormal_mineral_homeostasis1.35220837
59MP0002166_altered_tumor_susceptibility1.31072529
60MP0001765_abnormal_ion_homeostasis1.29671443
61MP0002102_abnormal_ear_morphology1.28717846
62MP0005253_abnormal_eye_physiology1.28710142
63MP0000371_diluted_coat_color1.26848760
64MP0005408_hypopigmentation1.25352036
65MP0000013_abnormal_adipose_tissue1.24413404
66MP0002928_abnormal_bile_duct1.23050834
67MP0009384_cardiac_valve_regurgitation1.21218641
68MP0003718_maternal_effect1.15260269
69MP0010386_abnormal_urinary_bladder1.13023095
70MP0005395_other_phenotype1.12992875
71MP0001764_abnormal_homeostasis1.12226374
72MP0004215_abnormal_myocardial_fiber1.10738359
73MP0003283_abnormal_digestive_organ1.09838690
74MP0005171_absent_coat_pigmentation1.09560024
75MP0005379_endocrine/exocrine_gland_phen1.06376350
76MP0006036_abnormal_mitochondrial_physio1.06034448
77MP0003186_abnormal_redox_activity1.05118110
78MP0005647_abnormal_sex_gland1.04598916
79MP0003786_premature_aging1.04289766
80MP0002896_abnormal_bone_mineralization1.03546520
81MP0005551_abnormal_eye_electrophysiolog1.03249413
82MP0006082_CNS_inflammation1.02756401
83MP0000598_abnormal_liver_morphology1.02074708
84MP0001984_abnormal_olfaction1.01637801
85MP0005584_abnormal_enzyme/coenzyme_acti1.00419778
86MP0000613_abnormal_salivary_gland0.99057828
87MP0010307_abnormal_tumor_latency0.98457680
88MP0005084_abnormal_gallbladder_morpholo0.96806417
89MP0005645_abnormal_hypothalamus_physiol0.94540418
90MP0009785_altered_susceptibility_to0.93009046
91MP0008057_abnormal_DNA_replication0.91504349
92MP0005310_abnormal_salivary_gland0.91493129
93MP0002148_abnormal_hypersensitivity_rea0.91294046
94MP0001661_extended_life_span0.90971918
95MP0002277_abnormal_respiratory_mucosa0.89529237
96MP0005410_abnormal_fertilization0.88125165
97MP0010368_abnormal_lymphatic_system0.86905505
98MP0003724_increased_susceptibility_to0.86862108
99* MP0009642_abnormal_blood_homeostasis0.86310423
100MP0002638_abnormal_pupillary_reflex0.86122729
101MP0008469_abnormal_protein_level0.85660810
102MP0002295_abnormal_pulmonary_circulatio0.84277557
103MP0000003_abnormal_adipose_tissue0.84005186
104MP0002095_abnormal_skin_pigmentation0.83279886
105MP0004782_abnormal_surfactant_physiolog0.83180518
106MP0002136_abnormal_kidney_physiology0.83123171
107MP0003959_abnormal_lean_body0.82300699
108MP0002876_abnormal_thyroid_physiology0.80464138
109MP0001986_abnormal_taste_sensitivity0.79664626
110MP0000604_amyloidosis0.79528730
111MP0005334_abnormal_fat_pad0.78671208
112MP0001324_abnormal_eye_pigmentation0.78281870
113MP0002254_reproductive_system_inflammat0.78263881
114MP0009764_decreased_sensitivity_to0.78088938
115MP0003045_fibrosis0.77620862
116MP0005167_abnormal_blood-brain_barrier0.76458007
117MP0000538_abnormal_urinary_bladder0.76393058
118MP0005670_abnormal_white_adipose0.75669856
119MP0004484_altered_response_of0.75515452
120MP0000647_abnormal_sebaceous_gland0.75315304
121MP0005165_increased_susceptibility_to0.75049657
122MP0002168_other_aberrant_phenotype0.74900121
123MP0009763_increased_sensitivity_to0.73619877
124MP0003656_abnormal_erythrocyte_physiolo0.73055200
125MP0008872_abnormal_physiological_respon0.72961300
126MP0000383_abnormal_hair_follicle0.72141143
127* MP0003953_abnormal_hormone_level0.71890525
128MP0003172_abnormal_lysosome_physiology0.71433420
129MP0005275_abnormal_skin_tensile0.69754219
130MP0002060_abnormal_skin_morphology0.69749829
131MP0005535_abnormal_body_temperature0.67919517
132MP0001845_abnormal_inflammatory_respons0.67429295
133MP0000639_abnormal_adrenal_gland0.65791412
134MP0002006_tumorigenesis0.65647616
135MP0003566_abnormal_cell_adhesion0.65614363
136MP0005448_abnormal_energy_balance0.64429132
137MP0009765_abnormal_xenobiotic_induced0.64351743
138MP0005375_adipose_tissue_phenotype0.64000783
139MP0000230_abnormal_systemic_arterial0.63496975
140MP0002971_abnormal_brown_adipose0.61738484
141MP0005666_abnormal_adipose_tissue0.61290339
142MP0004130_abnormal_muscle_cell0.60169824
143MP0004947_skin_inflammation0.58959761
144MP0001533_abnormal_skeleton_physiology0.58953002
145MP0004185_abnormal_adipocyte_glucose0.58450949
146MP0004272_abnormal_basement_membrane0.58127069
147MP0000462_abnormal_digestive_system0.56895566
148MP0003795_abnormal_bone_structure0.56179121
149MP0003436_decreased_susceptibility_to0.55816635
150MP0003638_abnormal_response/metabolism_0.55640707

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.45086933
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.39062162
3Intrahepatic cholestasis (HP:0001406)5.16708569
4Abnormality of the intrinsic pathway (HP:0010989)4.87239676
5Deep venous thrombosis (HP:0002625)4.81381708
6Abnormality of the common coagulation pathway (HP:0010990)4.66992940
7Hypoglycemic seizures (HP:0002173)4.61448570
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.57230167
9Hyperinsulinemic hypoglycemia (HP:0000825)4.44409567
10Xanthomatosis (HP:0000991)4.36282991
11Prolonged partial thromboplastin time (HP:0003645)4.24743376
12Ketoacidosis (HP:0001993)4.13580724
13Ketosis (HP:0001946)4.08514472
14Fat malabsorption (HP:0002630)3.81131443
15Complement deficiency (HP:0004431)3.81051331
16Conjugated hyperbilirubinemia (HP:0002908)3.69757419
17Symptomatic seizures (HP:0011145)3.66793275
18Hypothermia (HP:0002045)3.61105760
19Hypobetalipoproteinemia (HP:0003563)3.57008577
20Mucopolysacchariduria (HP:0008155)3.34040927
21Urinary glycosaminoglycan excretion (HP:0003541)3.34040927
22Hyperlipoproteinemia (HP:0010980)3.29618314
23Hyperglycemia (HP:0003074)3.25058853
24Generalized aminoaciduria (HP:0002909)3.24055809
25Large for gestational age (HP:0001520)3.17942112
26Tongue fasciculations (HP:0001308)3.12563965
27Late onset (HP:0003584)3.06403392
28Dysostosis multiplex (HP:0000943)3.06195702
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.04227201
30Joint hemorrhage (HP:0005261)3.02921807
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.00224081
32Abnormality of polysaccharide metabolism (HP:0011012)3.00224081
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.00224081
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.97411671
35Hematochezia (HP:0002573)2.96624521
36Hyperglycinuria (HP:0003108)2.95619949
37Hypolipoproteinemia (HP:0010981)2.94520714
38Abnormality of endocrine pancreas physiology (HP:0012093)2.92643992
39Abnormality of the pancreatic islet cells (HP:0006476)2.92643992
40Gout (HP:0001997)2.90191692
41Steatorrhea (HP:0002570)2.89683285
42Abnormality of purine metabolism (HP:0004352)2.85106886
43Hypoplasia of the fovea (HP:0007750)2.82908723
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.82908723
45Hyperammonemia (HP:0001987)2.80713376
46Hyperglycinemia (HP:0002154)2.80275807
47Abnormality of complement system (HP:0005339)2.78726691
48Hypoalphalipoproteinemia (HP:0003233)2.78243298
49Albinism (HP:0001022)2.77302179
50Metaphyseal dysplasia (HP:0100255)2.76482358
51Abnormality of vitamin B metabolism (HP:0004340)2.75853160
52Enlarged penis (HP:0000040)2.73755435
53Abnormality of serine family amino acid metabolism (HP:0010894)2.71539922
54Abnormality of glycine metabolism (HP:0010895)2.71539922
55Epidermoid cyst (HP:0200040)2.70516036
56Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.68973119
57Methylmalonic acidemia (HP:0002912)2.68285903
58Muscle fibrillation (HP:0010546)2.67837927
59Patchy hypopigmentation of hair (HP:0011365)2.66181941
60Myocardial infarction (HP:0001658)2.63138673
61Vacuolated lymphocytes (HP:0001922)2.60520550
62Abnormality of fatty-acid metabolism (HP:0004359)2.57419547
63Intestinal atresia (HP:0011100)2.57253101
64Hypokinesia (HP:0002375)2.56357988
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55029623
66Conjunctival hamartoma (HP:0100780)2.49554643
67Skin nodule (HP:0200036)2.48037730
68Progressive macrocephaly (HP:0004481)2.47821834
69Pancreatitis (HP:0001733)2.46777705
70Insulin-resistant diabetes mellitus (HP:0000831)2.46151057
71Pancreatic islet-cell hyperplasia (HP:0004510)2.44255547
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.43581160
73Abnormality of the fovea (HP:0000493)2.40053158
74Protuberant abdomen (HP:0001538)2.38666941
75Thyroiditis (HP:0100646)2.37751420
76Abnormality of nucleobase metabolism (HP:0010932)2.36224318
77Hyperbilirubinemia (HP:0002904)2.35561555
78Hamartoma of the eye (HP:0010568)2.34239247
79Congenital sensorineural hearing impairment (HP:0008527)2.32455351
80Neoplasm of the adrenal cortex (HP:0100641)2.31476674
81Abnormality of methionine metabolism (HP:0010901)2.31278628
82Disproportionate short-trunk short stature (HP:0003521)2.30649382
83Hepatocellular carcinoma (HP:0001402)2.29057743
84Abnormality of the renal cortex (HP:0011035)2.28041850
85Cutaneous melanoma (HP:0012056)2.25924148
86Increased CSF protein (HP:0002922)2.25825049
87Menorrhagia (HP:0000132)2.23376278
88Abdominal distention (HP:0003270)2.21912819
89Methylmalonic aciduria (HP:0012120)2.21826235
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.20849276
91Hepatic necrosis (HP:0002605)2.20608529
92Abnormality of vitamin metabolism (HP:0100508)2.16927129
93Back pain (HP:0003418)2.13295798
94Insulin resistance (HP:0000855)2.11696328
95Retinal atrophy (HP:0001105)2.09693452
96White forelock (HP:0002211)2.09433557
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09064506
98Abnormal protein N-linked glycosylation (HP:0012347)2.09064506
99Abnormal protein glycosylation (HP:0012346)2.09064506
100Abnormal glycosylation (HP:0012345)2.09064506
101Abnormality of proline metabolism (HP:0010907)2.08274374
102Hydroxyprolinuria (HP:0003080)2.08274374
103Mitral stenosis (HP:0001718)2.07716908
104Esophageal varix (HP:0002040)2.06825237
105Follicular hyperkeratosis (HP:0007502)2.06439930
106Abnormal enzyme/coenzyme activity (HP:0012379)2.06174686
107Neoplasm of the adrenal gland (HP:0100631)2.03887770
108Systemic lupus erythematosus (HP:0002725)2.03488207
109Type I transferrin isoform profile (HP:0003642)2.02895081
110Prostate neoplasm (HP:0100787)2.02864350
111Elevated alkaline phosphatase (HP:0003155)2.02035250
112Breast carcinoma (HP:0003002)2.01820850
113Abnormality of the vitamin B12 metabolism (HP:0004341)2.00975298
114Pancreatic cysts (HP:0001737)2.00478938
115Stomatitis (HP:0010280)2.00415770
116Increased CSF lactate (HP:0002490)2.00387024
117Renal cortical cysts (HP:0000803)2.00139372
118Sensorimotor neuropathy (HP:0007141)1.99891836
119Hypomagnesemia (HP:0002917)1.99010023
120Vascular calcification (HP:0004934)1.97032280
121Bilateral sensorineural hearing impairment (HP:0008619)1.96666158
122Exocrine pancreatic insufficiency (HP:0001738)1.96375481
123Hypercholesterolemia (HP:0003124)1.95956451
124Congenital, generalized hypertrichosis (HP:0004540)1.95556097
125Gaze-evoked nystagmus (HP:0000640)1.95200898
126Thoracolumbar scoliosis (HP:0002944)1.94901681
127Abnormality of alkaline phosphatase activity (HP:0004379)1.94358663
128Acute necrotizing encephalopathy (HP:0006965)1.93488229
129Abnormality of glycolipid metabolism (HP:0010969)1.92604753
130Abnormality of liposaccharide metabolism (HP:0010968)1.92604753
131Abnormality of glycosphingolipid metabolism (HP:0004343)1.92604753
132Cardiovascular calcification (HP:0011915)1.92239421
133Abnormal tarsal ossification (HP:0008369)1.91969717
134Hyperactive renin-angiotensin system (HP:0000841)1.91453809
135Aplasia/Hypoplasia of the macula (HP:0008059)1.91338565
136Glomerulonephritis (HP:0000099)1.89908028
137Abnormal foot bone ossification (HP:0010675)1.89811982
138Metabolic acidosis (HP:0001942)1.89295349
139Acute encephalopathy (HP:0006846)1.84650361
140Alkalosis (HP:0001948)1.84624676
141Proximal tubulopathy (HP:0000114)1.83684339
142Abnormal cartilage morphology (HP:0002763)1.82914963
143Sensory axonal neuropathy (HP:0003390)1.82753403
144Dicarboxylic aciduria (HP:0003215)1.81515322
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81515322
146Irritability (HP:0000737)1.79872495
147Spastic diplegia (HP:0001264)1.78254954
148Abnormal pancreas size (HP:0012094)1.78212620
149Fair hair (HP:0002286)1.77727688
150Acute hepatic failure (HP:0006554)1.77360373
151Hypoalbuminemia (HP:0003073)1.77281461
152Abnormal albumin level (HP:0012116)1.77281461
153Delayed CNS myelination (HP:0002188)1.74896483
154Recurrent gram-negative bacterial infections (HP:0005420)1.74157782
155Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73675928
156Mitochondrial inheritance (HP:0001427)1.73539691
157Generalized hypopigmentation of hair (HP:0011358)1.73469836
158Glycosuria (HP:0003076)1.73138548
159Abnormality of urine glucose concentration (HP:0011016)1.73138548
160Hepatocellular necrosis (HP:0001404)1.72629116
161Abnormal biliary tract morphology (HP:0012440)1.70764990
162Beaking of vertebral bodies (HP:0004568)1.70262697
163Death in childhood (HP:0003819)1.69247378
164Congenital stationary night blindness (HP:0007642)1.66883002
165Generalized hypopigmentation (HP:0007513)1.66752711
166Adrenal hypoplasia (HP:0000835)1.66715691
167Hemiparesis (HP:0001269)1.66021592
168Diminished movement (HP:0002374)1.65325853
169Tubular atrophy (HP:0000092)1.65113185
170Delayed gross motor development (HP:0002194)1.64987398
171Aplasia/hypoplasia of the uterus (HP:0008684)1.63754132
172Aqueductal stenosis (HP:0002410)1.62648891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.60841546
2TAOK34.64682749
3INSRR4.19702164
4BCKDK3.94883391
5FRK3.86365065
6SIK12.88388354
7ACVR1B2.75619060
8TRIB32.58439814
9BMPR1B2.54289598
10TRIM282.53964147
11FGFR42.31956890
12LATS12.31034155
13MAPK152.29934010
14ERBB32.17503842
15SCYL22.08508884
16FLT32.06708973
17PLK22.02530751
18PASK1.97336269
19EIF2AK11.94962361
20PTK61.92142747
21PKN21.89184733
22OXSR11.86881589
23WNK31.84300886
24MKNK21.83044900
25MAP3K121.78081089
26MAP3K21.77355416
27GRK11.76680962
28MAP4K21.60599603
29STK241.60007773
30STK38L1.57199326
31PIK3CG1.55663152
32PLK31.51063066
33IRAK31.45362218
34PDGFRA1.40287914
35JAK11.39836156
36TRPM71.37988869
37ADRBK21.34413263
38EPHA31.33914421
39HIPK21.33508963
40TNIK1.31642332
41TYK21.23115898
42WNK41.22845036
43MST1R1.21551763
44NEK91.15846346
45MAP3K31.15438938
46EIF2AK31.14917522
47BMPR21.14524471
48JAK21.13049976
49PDK21.10523562
50MET1.10212815
51JAK31.08848512
52AKT31.07412005
53EPHB11.06806130
54FGFR31.05506922
55TGFBR21.00541300
56PTK20.98222840
57ZAK0.96698081
58RIPK10.94722771
59PRKCE0.94653912
60MKNK10.91701484
61LRRK20.89899971
62MAP2K20.88967757
63NUAK10.86432939
64BCR0.86078884
65ZAP700.84985392
66PHKG20.84954908
67PHKG10.84954908
68CSNK1G10.84499920
69FER0.82631336
70SIK30.82536550
71ITK0.82328930
72MYLK0.81645855
73MAP3K10.81296726
74PTK2B0.76669229
75TBK10.75886224
76KDR0.71010683
77FGFR20.70557341
78CAMK1D0.70232986
79RET0.69812307
80PRKCH0.69733890
81WEE10.69283517
82CAMKK20.69192128
83DYRK1B0.68323635
84ERBB40.67051876
85MAP2K30.66532349
86IRAK10.66435125
87TSSK60.65204862
88PDGFRB0.64955604
89PRKCI0.64242391
90CSK0.63573695
91STK100.61403884
92PNCK0.61054697
93NLK0.60269823
94EIF2AK20.58505412
95IKBKB0.57989024
96MST40.57802621
97MTOR0.57733075
98MAPK110.57545550
99NTRK10.57207491
100NEK10.56099454
101GSK3A0.55230808
102CSNK1G30.54446897
103PBK0.52026088
104PRKD30.51757885
105STK30.51378860
106IGF1R0.51195469
107MARK30.51064194
108LIMK10.49894348
109TEC0.49607361
110MAP3K100.49447058
111MAPKAPK30.49237842
112CSNK1G20.48312400
113BTK0.47789908
114MAP3K70.47138696
115PAK20.46852421
116PRKAA10.46752790
117PRKAA20.45728454
118IKBKE0.45390329
119MAP2K60.45019005
120TTN0.44194614
121MAPKAPK50.44108507
122LMTK20.43311976
123TESK10.42893370
124CAMK1G0.42789531
125PIK3CA0.42751500
126ROCK10.42302655
127PLK40.42160938
128EEF2K0.41868622
129PRKD10.41674435
130ABL10.41051920
131PAK30.40103739
132CAMK2D0.39920581
133PDPK10.38436675
134STK160.37937108
135CDK60.37556396
136TAF10.36242718
137ADRBK10.35572062
138STK390.35424712
139MAP3K140.34548048
140EPHA20.34290264
141TIE10.33997411
142TXK0.33957585
143GRK70.33766777
144BRSK20.33292915
145EGFR0.32827679
146DAPK20.32709768
147PRKCQ0.31688955
148PINK10.31488531
149TGFBR10.31036645
150FGFR10.29687588
151BUB10.29620187
152PDK10.27651565
153ERBB20.27563768
154CSNK1A1L0.27558545
155ABL20.27466803
156STK40.27220370
157YES10.26883474
158MAP2K10.26818785
159ATM0.26558122
160PLK10.26269540
161PRKD20.25959584
162MAP4K10.25709625
163PRKACG0.25660612

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.29064240
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.33901938
3Nitrogen metabolism_Homo sapiens_hsa009103.05141583
4Protein export_Homo sapiens_hsa030602.93019331
5Sulfur metabolism_Homo sapiens_hsa009202.90403755
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79333794
7Proteasome_Homo sapiens_hsa030502.59806894
8Tryptophan metabolism_Homo sapiens_hsa003802.50166543
9* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.45684767
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42721245
11Fatty acid degradation_Homo sapiens_hsa000712.29715034
12Complement and coagulation cascades_Homo sapiens_hsa046102.19344671
13Arginine biosynthesis_Homo sapiens_hsa002202.16647412
14Selenocompound metabolism_Homo sapiens_hsa004502.13018231
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95697825
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91773023
17Collecting duct acid secretion_Homo sapiens_hsa049661.91008097
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90396265
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81287118
20Propanoate metabolism_Homo sapiens_hsa006401.74404060
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72770355
22Fat digestion and absorption_Homo sapiens_hsa049751.70227265
23Butanoate metabolism_Homo sapiens_hsa006501.69056281
24Peroxisome_Homo sapiens_hsa041461.68707326
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68524700
26Histidine metabolism_Homo sapiens_hsa003401.55131633
27Folate biosynthesis_Homo sapiens_hsa007901.54719912
28Fatty acid metabolism_Homo sapiens_hsa012121.50899594
29Starch and sucrose metabolism_Homo sapiens_hsa005001.50593438
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49543907
31Sphingolipid metabolism_Homo sapiens_hsa006001.46628812
32ABC transporters_Homo sapiens_hsa020101.45517097
33PPAR signaling pathway_Homo sapiens_hsa033201.44226450
34Type I diabetes mellitus_Homo sapiens_hsa049401.39844489
35Caffeine metabolism_Homo sapiens_hsa002321.37707945
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35097810
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32611226
38Staphylococcus aureus infection_Homo sapiens_hsa051501.31139608
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28927452
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28513064
41beta-Alanine metabolism_Homo sapiens_hsa004101.25990315
42Mineral absorption_Homo sapiens_hsa049781.24757438
43N-Glycan biosynthesis_Homo sapiens_hsa005101.23592070
44Non-homologous end-joining_Homo sapiens_hsa034501.22544873
45Bile secretion_Homo sapiens_hsa049761.21851105
46Chemical carcinogenesis_Homo sapiens_hsa052041.21565688
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.19031506
48Basal transcription factors_Homo sapiens_hsa030221.14264917
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13450578
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12382352
51Rheumatoid arthritis_Homo sapiens_hsa053231.11311992
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.08371473
53Homologous recombination_Homo sapiens_hsa034401.07579032
54Phenylalanine metabolism_Homo sapiens_hsa003601.07185804
55Ether lipid metabolism_Homo sapiens_hsa005651.07142681
56Regulation of autophagy_Homo sapiens_hsa041401.05461247
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04956684
58Oxidative phosphorylation_Homo sapiens_hsa001901.04499775
59Tyrosine metabolism_Homo sapiens_hsa003500.98539737
60Pyruvate metabolism_Homo sapiens_hsa006200.96469540
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.95843351
62Retinol metabolism_Homo sapiens_hsa008300.95164911
63Pancreatic secretion_Homo sapiens_hsa049720.90658102
64Protein digestion and absorption_Homo sapiens_hsa049740.89662631
65Other glycan degradation_Homo sapiens_hsa005110.89375136
66Lysosome_Homo sapiens_hsa041420.88612484
67Glycerolipid metabolism_Homo sapiens_hsa005610.88037123
68Circadian rhythm_Homo sapiens_hsa047100.87401469
69Lysine degradation_Homo sapiens_hsa003100.87305334
70Vitamin digestion and absorption_Homo sapiens_hsa049770.85756659
71Insulin resistance_Homo sapiens_hsa049310.84126638
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82490880
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81384228
74Arginine and proline metabolism_Homo sapiens_hsa003300.80566817
75Fatty acid elongation_Homo sapiens_hsa000620.79324403
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76813676
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.72535011
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69753287
79Renin-angiotensin system_Homo sapiens_hsa046140.69629280
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69349248
81RNA degradation_Homo sapiens_hsa030180.68504338
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68449230
83Carbon metabolism_Homo sapiens_hsa012000.67553231
84Arachidonic acid metabolism_Homo sapiens_hsa005900.65477094
85Sulfur relay system_Homo sapiens_hsa041220.64327816
86Biosynthesis of amino acids_Homo sapiens_hsa012300.64250336
87Prion diseases_Homo sapiens_hsa050200.63930536
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63302750
89Thyroid hormone synthesis_Homo sapiens_hsa049180.61502441
90Steroid biosynthesis_Homo sapiens_hsa001000.60930490
91Phototransduction_Homo sapiens_hsa047440.60261792
92Galactose metabolism_Homo sapiens_hsa000520.59453565
93Fanconi anemia pathway_Homo sapiens_hsa034600.56743452
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56508532
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54317755
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53214637
97Ovarian steroidogenesis_Homo sapiens_hsa049130.51890972
98Type II diabetes mellitus_Homo sapiens_hsa049300.49539597
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.45884448
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44957578
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44500474
102Dorso-ventral axis formation_Homo sapiens_hsa043200.44466996
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44107804
104RNA polymerase_Homo sapiens_hsa030200.44000139
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43538788
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.42763503
107Insulin secretion_Homo sapiens_hsa049110.41377894
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41281975
109Phagosome_Homo sapiens_hsa041450.39987071
110Vibrio cholerae infection_Homo sapiens_hsa051100.39755555
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38654316
112Glutathione metabolism_Homo sapiens_hsa004800.36320595
113African trypanosomiasis_Homo sapiens_hsa051430.35991573
114Glucagon signaling pathway_Homo sapiens_hsa049220.35367338
115One carbon pool by folate_Homo sapiens_hsa006700.34731352
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34726298
117Metabolic pathways_Homo sapiens_hsa011000.31197168
118Pentose phosphate pathway_Homo sapiens_hsa000300.30548635
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30086681
120Antigen processing and presentation_Homo sapiens_hsa046120.28734669
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28602348
122Linoleic acid metabolism_Homo sapiens_hsa005910.27967599
123Mismatch repair_Homo sapiens_hsa034300.27230150
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.27218803
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.26893709
126Fructose and mannose metabolism_Homo sapiens_hsa000510.26796178
127p53 signaling pathway_Homo sapiens_hsa041150.26741557
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26681750
129Asthma_Homo sapiens_hsa053100.26668699
130AMPK signaling pathway_Homo sapiens_hsa041520.24323561
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23447350
132Fatty acid biosynthesis_Homo sapiens_hsa000610.22193217
133Prostate cancer_Homo sapiens_hsa052150.19178045
134Amoebiasis_Homo sapiens_hsa051460.17261082
135Vitamin B6 metabolism_Homo sapiens_hsa007500.14667100
136Prolactin signaling pathway_Homo sapiens_hsa049170.13765026
137Legionellosis_Homo sapiens_hsa051340.13189078

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