DNAJC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.45115263
2DNA unwinding involved in DNA replication (GO:0006268)4.38491428
3DNA strand elongation involved in DNA replication (GO:0006271)4.31526913
4DNA replication initiation (GO:0006270)4.28454322
5formation of translation preinitiation complex (GO:0001731)4.27773587
6ribosomal large subunit biogenesis (GO:0042273)4.26442156
7nuclear pore organization (GO:0006999)4.18927961
8nuclear pore complex assembly (GO:0051292)4.13886433
9DNA strand elongation (GO:0022616)4.10301042
10ribosome assembly (GO:0042255)4.09397385
11mitotic metaphase plate congression (GO:0007080)4.09301284
12ribosomal small subunit assembly (GO:0000028)4.08010749
13DNA replication checkpoint (GO:0000076)4.05242002
14proteasome assembly (GO:0043248)4.00879839
15protein localization to kinetochore (GO:0034501)4.00135819
16kinetochore organization (GO:0051383)3.99885169
17telomere maintenance via semi-conservative replication (GO:0032201)3.97680608
18nucleobase biosynthetic process (GO:0046112)3.93406759
19mitotic nuclear envelope disassembly (GO:0007077)3.89566618
20chromatin remodeling at centromere (GO:0031055)3.84469497
21viral transcription (GO:0019083)3.82693576
22translational termination (GO:0006415)3.82554129
23DNA deamination (GO:0045006)3.78986942
24purine nucleobase biosynthetic process (GO:0009113)3.77363962
25ribonucleoprotein complex biogenesis (GO:0022613)3.76919925
26CENP-A containing nucleosome assembly (GO:0034080)3.73850665
27telomere maintenance via recombination (GO:0000722)3.72854380
28DNA replication-dependent nucleosome assembly (GO:0006335)3.72517118
29DNA replication-dependent nucleosome organization (GO:0034723)3.72517118
30ribosome biogenesis (GO:0042254)3.69686523
31protein localization to chromosome, centromeric region (GO:0071459)3.67458533
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.66280839
33regulation of mitotic spindle checkpoint (GO:1903504)3.66280839
34translational initiation (GO:0006413)3.63766026
35membrane disassembly (GO:0030397)3.62672814
36nuclear envelope disassembly (GO:0051081)3.62672814
37ribosomal small subunit biogenesis (GO:0042274)3.61730442
38mitotic recombination (GO:0006312)3.60598809
39metaphase plate congression (GO:0051310)3.55234383
40DNA replication-independent nucleosome assembly (GO:0006336)3.54515596
41DNA replication-independent nucleosome organization (GO:0034724)3.54515596
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53967184
43regulation of DNA endoreduplication (GO:0032875)3.52705440
44translational elongation (GO:0006414)3.51027384
45rRNA modification (GO:0000154)3.50127974
46kinetochore assembly (GO:0051382)3.49466067
47rRNA processing (GO:0006364)3.46223203
48folic acid-containing compound biosynthetic process (GO:0009396)3.45144752
49synapsis (GO:0007129)3.43785484
50IMP biosynthetic process (GO:0006188)3.43364490
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.42712080
52histone exchange (GO:0043486)3.42554939
53regulation of spindle organization (GO:0090224)3.40338391
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.38982466
55telomere maintenance via telomere lengthening (GO:0010833)3.38455613
56regulation of mitochondrial translation (GO:0070129)3.37483568
57rRNA metabolic process (GO:0016072)3.37098881
58mitotic chromosome condensation (GO:0007076)3.35905314
59mitotic sister chromatid cohesion (GO:0007064)3.35880692
60replication fork processing (GO:0031297)3.27118536
61attachment of spindle microtubules to kinetochore (GO:0008608)3.26067586
62cellular component biogenesis (GO:0044085)3.24964353
63DNA duplex unwinding (GO:0032508)3.24547225
64spliceosomal snRNP assembly (GO:0000387)3.23497820
65DNA geometric change (GO:0032392)3.23471528
66pore complex assembly (GO:0046931)3.22629790
67DNA catabolic process, exonucleolytic (GO:0000738)3.20945983
68mitotic sister chromatid segregation (GO:0000070)3.19600070
69centriole replication (GO:0007099)3.19497288
70regulation of centrosome cycle (GO:0046605)3.19483770
71establishment of chromosome localization (GO:0051303)3.17759167
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.17725387
73rRNA methylation (GO:0031167)3.15743919
74transcription elongation from RNA polymerase III promoter (GO:0006385)3.15347867
75termination of RNA polymerase III transcription (GO:0006386)3.15347867
76IMP metabolic process (GO:0046040)3.14953287
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11936118
78mitochondrial RNA metabolic process (GO:0000959)3.11835472
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.11411104
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10519811
81DNA damage response, detection of DNA damage (GO:0042769)3.08489815
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07114580
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06341482
84protein K6-linked ubiquitination (GO:0085020)3.06205903
85positive regulation of chromosome segregation (GO:0051984)3.05864612
86DNA topological change (GO:0006265)3.05265899
87establishment of protein localization to mitochondrial membrane (GO:0090151)3.04993169
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.04899726
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04899726
90cellular protein complex disassembly (GO:0043624)3.04819323
91DNA double-strand break processing (GO:0000729)3.04806987
92double-strand break repair via homologous recombination (GO:0000724)3.04377234
93recombinational repair (GO:0000725)3.02599356
94cotranslational protein targeting to membrane (GO:0006613)3.02563156
95protein targeting to ER (GO:0045047)3.02216151
96chromatin assembly or disassembly (GO:0006333)3.02126946
97positive regulation of histone H3-K4 methylation (GO:0051571)3.01820099
98regulation of centriole replication (GO:0046599)3.01201702
99regulation of histone H3-K9 methylation (GO:0051570)3.00576979
100termination of RNA polymerase II transcription (GO:0006369)2.99916049
101negative regulation of chromosome segregation (GO:0051985)2.99532529
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99390008
103meiotic chromosome segregation (GO:0045132)2.99079235
104spindle checkpoint (GO:0031577)2.99049045
105establishment of integrated proviral latency (GO:0075713)2.98485051
106regulation of chromosome segregation (GO:0051983)2.98425854
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.98315326
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98315326
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98315326
110negative regulation of sister chromatid segregation (GO:0033046)2.98315326
111transcription from mitochondrial promoter (GO:0006390)2.98069479
112ncRNA processing (GO:0034470)2.97902472
113sister chromatid segregation (GO:0000819)2.97601519
114ncRNA metabolic process (GO:0034660)2.96797463
115regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96778211
116viral life cycle (GO:0019058)2.96580741
117histone mRNA metabolic process (GO:0008334)2.96496035
118heterochromatin organization (GO:0070828)2.96198047
119regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95800049
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93729547
121pseudouridine synthesis (GO:0001522)2.93647418
122maturation of 5.8S rRNA (GO:0000460)2.93149077
123spindle assembly checkpoint (GO:0071173)2.93135428
124translation (GO:0006412)2.92119063
125regulation of helicase activity (GO:0051095)2.91762753
126RNA splicing, via transesterification reactions (GO:0000375)2.91202437
127mitotic spindle assembly checkpoint (GO:0007094)2.90825510
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90152900
129negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89696185
130RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89547206
131mRNA splicing, via spliceosome (GO:0000398)2.89547206
132mitotic spindle checkpoint (GO:0071174)2.89543684
133ATP-dependent chromatin remodeling (GO:0043044)2.88902806
134regulation of mitotic spindle organization (GO:0060236)2.88586453
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.88380686
136establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87473243
137spliceosomal complex assembly (GO:0000245)2.84740487
138translesion synthesis (GO:0019985)2.83490497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.89825950
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45846997
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.12995978
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87968062
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.54708124
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20540596
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13710519
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86995473
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83752871
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.78831570
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.77726219
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74851794
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.69024687
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.68590649
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.54815762
16* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53100446
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33067036
18XRN2_22483619_ChIP-Seq_HELA_Human2.31180587
19* VDR_23849224_ChIP-Seq_CD4+_Human2.29932435
20AR_21909140_ChIP-Seq_LNCAP_Human2.23129092
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15167754
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.12980809
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.12036972
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.04149808
25DCP1A_22483619_ChIP-Seq_HELA_Human2.00670771
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98865884
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.95710403
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93470974
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90617394
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89412826
31TTF2_22483619_ChIP-Seq_HELA_Human1.86938678
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83423724
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82516048
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79884162
35* GABP_19822575_ChIP-Seq_HepG2_Human1.79254065
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71768103
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71237722
38ELK1_19687146_ChIP-ChIP_HELA_Human1.70603495
39MYC_22102868_ChIP-Seq_BL_Human1.68794472
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66169992
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60466164
42CIITA_25753668_ChIP-Seq_RAJI_Human1.59663165
43EWS_26573619_Chip-Seq_HEK293_Human1.58612112
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57558517
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57055405
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54541545
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53886447
48* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53597737
49KDM5A_27292631_Chip-Seq_BREAST_Human1.53136717
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51672976
51* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50729568
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50670343
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45244404
54FUS_26573619_Chip-Seq_HEK293_Human1.43123842
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40851571
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38870427
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38766644
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.37221145
59ZNF274_21170338_ChIP-Seq_K562_Hela1.32932702
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29679613
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29620835
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.28878077
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28706693
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.28387850
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24718832
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22553028
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21933060
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20650274
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20163450
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17955613
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16575642
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16027555
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15346943
74TFEB_21752829_ChIP-Seq_HELA_Human1.14967347
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14030219
76VDR_22108803_ChIP-Seq_LS180_Human1.13460488
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11860771
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11301346
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09408642
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06360068
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04642388
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.03262635
83* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02991469
84MYC_18940864_ChIP-ChIP_HL60_Human1.02205531
85SPI1_23547873_ChIP-Seq_NB4_Human1.01278865
86* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00584632
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.99540204
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98910949
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98893156
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95400412
91SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92692471
92VDR_21846776_ChIP-Seq_THP-1_Human0.91689153
93IRF1_19129219_ChIP-ChIP_H3396_Human0.90856367
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89360016
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86351615
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85838021
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85337679
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84346300
99FLI1_27457419_Chip-Seq_LIVER_Mouse0.83493504
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82763145
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.82527001
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81999882
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.79830734
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.79699470
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76983705
106POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76141844
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76103960
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76103960
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76103960
110ELF5_23300383_ChIP-Seq_T47D_Human0.76082591
111TP53_22573176_ChIP-Seq_HFKS_Human0.75616757
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73431499
113SOX2_16153702_ChIP-ChIP_HESCs_Human0.72553475
114* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71994334
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71852497
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71563308
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71464722
118IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.70989805
119MYB_26560356_Chip-Seq_TH1_Human0.70476106
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.68417779
121IGF1R_20145208_ChIP-Seq_DFB_Human0.67895964
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.67376203
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66145991
124* ER_23166858_ChIP-Seq_MCF-7_Human0.62622175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.64504640
2MP0010094_abnormal_chromosome_stability4.74168495
3MP0004957_abnormal_blastocyst_morpholog4.60509148
4MP0003111_abnormal_nucleus_morphology4.49742376
5MP0008057_abnormal_DNA_replication4.05754634
6MP0003077_abnormal_cell_cycle3.99694035
7MP0008058_abnormal_DNA_repair3.48365679
8MP0008877_abnormal_DNA_methylation2.80777151
9MP0008007_abnormal_cellular_replicative2.68304312
10MP0006292_abnormal_olfactory_placode2.64753881
11MP0008932_abnormal_embryonic_tissue2.58626562
12MP0002396_abnormal_hematopoietic_system2.53047535
13MP0003123_paternal_imprinting2.51380528
14MP0010352_gastrointestinal_tract_polyps2.48054050
15MP0001730_embryonic_growth_arrest2.46495027
16MP0000350_abnormal_cell_proliferation2.29303286
17MP0010307_abnormal_tumor_latency2.25226582
18MP0003786_premature_aging2.00966766
19MP0009697_abnormal_copulation1.97868708
20MP0000490_abnormal_crypts_of1.88076213
21MP0001672_abnormal_embryogenesis/_devel1.79671635
22MP0005380_embryogenesis_phenotype1.79671635
23MP0001697_abnormal_embryo_size1.77093182
24MP0009379_abnormal_foot_pigmentation1.69383810
25MP0004808_abnormal_hematopoietic_stem1.67503687
26MP0008995_early_reproductive_senescence1.66782349
27MP0006035_abnormal_mitochondrial_morpho1.65368348
28MP0003984_embryonic_growth_retardation1.64613216
29MP0002088_abnormal_embryonic_growth/wei1.60805807
30MP0002080_prenatal_lethality1.60221543
31MP0006036_abnormal_mitochondrial_physio1.56069032
32MP0002210_abnormal_sex_determination1.54827477
33MP0000313_abnormal_cell_death1.51259833
34MP0009333_abnormal_splenocyte_physiolog1.49824742
35MP0002019_abnormal_tumor_incidence1.49612408
36MP0005076_abnormal_cell_differentiation1.49367833
37MP0002085_abnormal_embryonic_tissue1.48381714
38MP0004147_increased_porphyrin_level1.48181884
39MP0003763_abnormal_thymus_physiology1.46784186
40MP0002086_abnormal_extraembryonic_tissu1.45858555
41MP0002084_abnormal_developmental_patter1.44356180
42MP0004197_abnormal_fetal_growth/weight/1.42395622
43MP0003567_abnormal_fetal_cardiomyocyte1.41601203
44MP0001929_abnormal_gametogenesis1.39828279
45MP0001145_abnormal_male_reproductive1.36326131
46MP0006072_abnormal_retinal_apoptosis1.35430033
47MP0003718_maternal_effect1.34203832
48MP0000703_abnormal_thymus_morphology1.29343388
49MP0001545_abnormal_hematopoietic_system1.27328064
50MP0005397_hematopoietic_system_phenotyp1.27328064
51MP0002398_abnormal_bone_marrow1.26205072
52MP0002938_white_spotting1.21043912
53MP0003121_genomic_imprinting1.17761638
54MP0002722_abnormal_immune_system1.16092372
55MP0001293_anophthalmia1.14469093
56MP0000653_abnormal_sex_gland1.14452564
57MP0003315_abnormal_perineum_morphology1.12078618
58MP0003890_abnormal_embryonic-extraembry1.10889190
59MP0003937_abnormal_limbs/digits/tail_de1.08572469
60MP0000689_abnormal_spleen_morphology1.08548332
61MP0001188_hyperpigmentation1.03381895
62MP0003787_abnormal_imprinting1.01969596
63MP0003136_yellow_coat_color0.95688596
64MP0002429_abnormal_blood_cell0.93829592
65MP0000372_irregular_coat_pigmentation0.92632075
66MP0001764_abnormal_homeostasis0.91433113
67MP0002160_abnormal_reproductive_system0.89402204
68MP0000716_abnormal_immune_system0.88575830
69MP0000358_abnormal_cell_content/0.87862458
70MP0000858_altered_metastatic_potential0.87393126
71MP0000537_abnormal_urethra_morphology0.87321850
72MP0000427_abnormal_hair_cycle0.86795992
73MP0003221_abnormal_cardiomyocyte_apopto0.85684474
74MP0003698_abnormal_male_reproductive0.85169783
75MP0001800_abnormal_humoral_immune0.83745291
76MP0000631_abnormal_neuroendocrine_gland0.82740912
77MP0009672_abnormal_birth_weight0.81265282
78MP0003699_abnormal_female_reproductive0.81254450
79MP0005389_reproductive_system_phenotype0.81176291
80MP0001529_abnormal_vocalization0.80796138
81MP0001853_heart_inflammation0.80115443
82MP0005384_cellular_phenotype0.79679608
83MP0005075_abnormal_melanosome_morpholog0.79590606
84MP0001835_abnormal_antigen_presentation0.78970706
85MP0005410_abnormal_fertilization0.77278158
86MP0003448_altered_tumor_morphology0.75707665
87MP0005621_abnormal_cell_physiology0.75665405
88MP0001119_abnormal_female_reproductive0.74681833
89MP0002452_abnormal_antigen_presenting0.74193157
90MP0002006_tumorigenesis0.74180281
91MP0002420_abnormal_adaptive_immunity0.73675033
92MP0008872_abnormal_physiological_respon0.73388194
93MP0005266_abnormal_metabolism0.73191536
94MP0005395_other_phenotype0.72830401
95MP0003119_abnormal_digestive_system0.72807566
96MP0001819_abnormal_immune_cell0.72762768
97MP0003941_abnormal_skin_development0.72085818
98MP0002405_respiratory_system_inflammati0.71183978
99MP0001915_intracranial_hemorrhage0.70599295
100MP0000383_abnormal_hair_follicle0.70588015
101MP0002102_abnormal_ear_morphology0.70286190
102MP0002163_abnormal_gland_morphology0.69330554
103MP0009053_abnormal_anal_canal0.68522954
104MP0005671_abnormal_response_to0.68323895
105MP0005551_abnormal_eye_electrophysiolog0.68082885
106MP0005408_hypopigmentation0.68074380
107MP0003646_muscle_fatigue0.67945247
108MP0002166_altered_tumor_susceptibility0.67438412
109MP0009703_decreased_birth_body0.66969940
110MP0003656_abnormal_erythrocyte_physiolo0.66684746
111MP0000477_abnormal_intestine_morphology0.66505433
112MP0010030_abnormal_orbit_morphology0.66397248
113MP0002161_abnormal_fertility/fecundity0.65335267
114MP0002723_abnormal_immune_serum0.65186178
115MP0002837_dystrophic_cardiac_calcinosis0.64121260
116MP0009278_abnormal_bone_marrow0.63596947
117MP0001919_abnormal_reproductive_system0.63478961
118MP0003186_abnormal_redox_activity0.62996878
119MP0003936_abnormal_reproductive_system0.62713781
120MP0002653_abnormal_ependyma_morphology0.62348137
121MP0005023_abnormal_wound_healing0.62005485
122MP0003705_abnormal_hypodermis_morpholog0.61857559
123MP0000647_abnormal_sebaceous_gland0.61395744
124MP0005501_abnormal_skin_physiology0.61067706
125MP0005646_abnormal_pituitary_gland0.60204857
126MP0000685_abnormal_immune_system0.59901364
127MP0001485_abnormal_pinna_reflex0.59403354
128MP0002697_abnormal_eye_size0.58033408
129MP0003806_abnormal_nucleotide_metabolis0.58016343
130MP0003566_abnormal_cell_adhesion0.57309251
131MP0005084_abnormal_gallbladder_morpholo0.56956202
132MP0005253_abnormal_eye_physiology0.56923529
133MP0005391_vision/eye_phenotype0.56725003
134MP0002177_abnormal_outer_ear0.56145456
135MP0002092_abnormal_eye_morphology0.55403610
136MP0005174_abnormal_tail_pigmentation0.54321753
137MP0010155_abnormal_intestine_physiology0.54301314
138MP0003943_abnormal_hepatobiliary_system0.53955377
139MP0002111_abnormal_tail_morphology0.53281461
140MP0001881_abnormal_mammary_gland0.52525476
141MP0002095_abnormal_skin_pigmentation0.52401383
142MP0008789_abnormal_olfactory_epithelium0.52158756
143MP0001286_abnormal_eye_development0.51803789

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.56699626
2Birth length less than 3rd percentile (HP:0003561)4.49158054
3Abnormality of cells of the erythroid lineage (HP:0012130)4.16548647
4Chromsome breakage (HP:0040012)3.94984648
5Abnormal number of erythroid precursors (HP:0012131)3.83467228
6Abnormality of the anterior horn cell (HP:0006802)3.55863243
7Degeneration of anterior horn cells (HP:0002398)3.55863243
8Abnormality of chromosome stability (HP:0003220)3.53325005
9Colon cancer (HP:0003003)3.52601251
10Breast hypoplasia (HP:0003187)3.50861752
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47829340
12Acute necrotizing encephalopathy (HP:0006965)3.43943973
13Oral leukoplakia (HP:0002745)3.39839787
14Abnormality of the preputium (HP:0100587)3.29821069
15Acute encephalopathy (HP:0006846)3.19398268
16Increased hepatocellular lipid droplets (HP:0006565)3.17751131
17Increased CSF lactate (HP:0002490)3.16843934
18Selective tooth agenesis (HP:0001592)3.14080937
19Macrocytic anemia (HP:0001972)3.08738093
20Abnormal mitochondria in muscle tissue (HP:0008316)3.07687547
21Medulloblastoma (HP:0002885)3.03296360
22Meckel diverticulum (HP:0002245)3.02414869
23Impulsivity (HP:0100710)3.01684579
24Pallor (HP:0000980)3.01429519
25Carpal bone hypoplasia (HP:0001498)3.01242571
26Patellar aplasia (HP:0006443)2.97965142
27Absent thumb (HP:0009777)2.97292294
28Mitochondrial inheritance (HP:0001427)2.96789108
29Agnosia (HP:0010524)2.94766281
30Lipid accumulation in hepatocytes (HP:0006561)2.91730429
31Rough bone trabeculation (HP:0100670)2.90643201
32Ependymoma (HP:0002888)2.89999406
33Rhabdomyosarcoma (HP:0002859)2.86377315
34Progressive macrocephaly (HP:0004481)2.84950373
35Myelodysplasia (HP:0002863)2.82326145
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.82213513
37Abnormality of the ileum (HP:0001549)2.80671756
38Aplasia/Hypoplasia of the patella (HP:0006498)2.79769915
39Aplastic anemia (HP:0001915)2.70339367
40Hepatocellular necrosis (HP:0001404)2.61751109
41Neoplasm of the pancreas (HP:0002894)2.61039247
42Increased serum lactate (HP:0002151)2.56519555
43Small intestinal stenosis (HP:0012848)2.54406538
44Duodenal stenosis (HP:0100867)2.54406538
4511 pairs of ribs (HP:0000878)2.52575866
46Cerebral edema (HP:0002181)2.52004226
47Prominent nose (HP:0000448)2.49752952
48Absent radius (HP:0003974)2.49185945
49Premature graying of hair (HP:0002216)2.48628688
50Basal cell carcinoma (HP:0002671)2.48169712
51Trismus (HP:0000211)2.46929660
52Pancreatic cysts (HP:0001737)2.45735187
53Pancreatic fibrosis (HP:0100732)2.44430541
54Horseshoe kidney (HP:0000085)2.44081282
55Premature ovarian failure (HP:0008209)2.43316165
56Ectopic kidney (HP:0000086)2.43069167
57Bone marrow hypocellularity (HP:0005528)2.42076866
58Hepatic necrosis (HP:0002605)2.41977595
59Abnormal spermatogenesis (HP:0008669)2.38758532
60Microvesicular hepatic steatosis (HP:0001414)2.37631151
61Microretrognathia (HP:0000308)2.31412612
62Cleft eyelid (HP:0000625)2.30754237
63Proximal placement of thumb (HP:0009623)2.30527178
64Multiple enchondromatosis (HP:0005701)2.29486924
65Cellular immunodeficiency (HP:0005374)2.28335873
66Aplasia involving forearm bones (HP:0009822)2.26404010
67Absent forearm bone (HP:0003953)2.26404010
68Squamous cell carcinoma (HP:0002860)2.24860328
69Volvulus (HP:0002580)2.24508683
70Type I transferrin isoform profile (HP:0003642)2.24112104
71Abnormal number of incisors (HP:0011064)2.23961904
72Abnormality of midbrain morphology (HP:0002418)2.23137605
73Molar tooth sign on MRI (HP:0002419)2.23137605
74Cerebral hypomyelination (HP:0006808)2.22337214
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.18849311
76Sloping forehead (HP:0000340)2.18388408
77Abnormality of alanine metabolism (HP:0010916)2.17933525
78Hyperalaninemia (HP:0003348)2.17933525
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17933525
80Tracheoesophageal fistula (HP:0002575)2.17523891
81Deviation of the thumb (HP:0009603)2.17304524
82Thrombocytosis (HP:0001894)2.17220781
83Abnormality of the pons (HP:0007361)2.15176562
84Abnormal trabecular bone morphology (HP:0100671)2.14925308
85Triphalangeal thumb (HP:0001199)2.14491829
86Biliary tract neoplasm (HP:0100574)2.13647674
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13390958
88Atresia of the external auditory canal (HP:0000413)2.13201273
89Lymphoma (HP:0002665)2.12990437
90Pelvic girdle muscle weakness (HP:0003749)2.08381725
91Hypoplasia of the pons (HP:0012110)2.07732348
92Abnormality of the labia minora (HP:0012880)2.07283418
93Abnormality of the duodenum (HP:0002246)2.05591965
94Increased nuchal translucency (HP:0010880)2.05524182
95Respiratory difficulties (HP:0002880)2.05073277
96Abnormal lung lobation (HP:0002101)2.02707765
97Lactic acidosis (HP:0003128)2.02481009
98Supernumerary spleens (HP:0009799)2.00781432
99Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99673303
100IgM deficiency (HP:0002850)1.99567609
101Neoplasm of striated muscle (HP:0009728)1.95983087
102Cafe-au-lait spot (HP:0000957)1.95679855
103Megaloblastic anemia (HP:0001889)1.95302324
104Renal Fanconi syndrome (HP:0001994)1.94628957
105Amaurosis fugax (HP:0100576)1.94344143
106Secondary amenorrhea (HP:0000869)1.94231950
107Abnormality of DNA repair (HP:0003254)1.93326472
108Facial hemangioma (HP:0000329)1.92398054
109Increased intramyocellular lipid droplets (HP:0012240)1.92131053
110Entropion (HP:0000621)1.92053556
111Abnormal protein glycosylation (HP:0012346)1.91661131
112Abnormal glycosylation (HP:0012345)1.91661131
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91661131
114Abnormal protein N-linked glycosylation (HP:0012347)1.91661131
115Glossoptosis (HP:0000162)1.91655977
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.90312846
117Poikiloderma (HP:0001029)1.90084552
118Neoplasm of the colon (HP:0100273)1.90065818
119High pitched voice (HP:0001620)1.89509261
120Stenosis of the external auditory canal (HP:0000402)1.89430303
121Nephroblastoma (Wilms tumor) (HP:0002667)1.89124234
122Nephronophthisis (HP:0000090)1.88713282
123Overlapping toe (HP:0001845)1.87945423
124Abnormality of methionine metabolism (HP:0010901)1.86281754
125Abnormality of the carotid arteries (HP:0005344)1.86138423
126Median cleft lip (HP:0000161)1.86028394
1273-Methylglutaconic aciduria (HP:0003535)1.85559292
128Glioma (HP:0009733)1.85411867
129Oligodactyly (hands) (HP:0001180)1.80300364
130Abnormality of homocysteine metabolism (HP:0010919)1.80221046
131Homocystinuria (HP:0002156)1.80221046
132Embryonal renal neoplasm (HP:0011794)1.79992749
133Short tibia (HP:0005736)1.79328300
134Pancytopenia (HP:0001876)1.79034465
135Missing ribs (HP:0000921)1.78936000
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78513036
137Acute myeloid leukemia (HP:0004808)1.78245323
138Methylmalonic acidemia (HP:0002912)1.77298492
139Renal cortical cysts (HP:0000803)1.76741372
140Facial cleft (HP:0002006)1.76678259
141Clubbing of toes (HP:0100760)1.76149934
142Short thumb (HP:0009778)1.75579105
143Abnormality of serum amino acid levels (HP:0003112)1.75501787
144Acute lymphatic leukemia (HP:0006721)1.74300222
145True hermaphroditism (HP:0010459)1.74170218
146Hypoplasia of the radius (HP:0002984)1.74092026
147Abnormality of the astrocytes (HP:0100707)1.73947335
148Astrocytoma (HP:0009592)1.73947335
149Abnormality of reticulocytes (HP:0004312)1.73331020
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.72153158
151Pendular nystagmus (HP:0012043)1.71934243
152Progressive muscle weakness (HP:0003323)1.71338035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.30944494
2CDC74.23932749
3BUB14.04013489
4EIF2AK13.72185288
5NEK23.17061736
6SRPK12.47809666
7NME22.46481333
8TTK2.33930738
9PLK42.30122484
10ACVR1B2.28572690
11TSSK62.24779322
12CDK122.22068285
13NUAK12.16801516
14PLK11.94464518
15NEK11.93677833
16RPS6KA41.90335988
17EIF2AK31.88918398
18TLK11.88074445
19VRK21.78894839
20ATR1.75597727
21MKNK11.72381616
22RPS6KB21.68284321
23AURKB1.68166510
24BMPR1B1.65894645
25TESK21.64613452
26CDK71.60902095
27BRSK21.58688344
28DYRK31.56935809
29PNCK1.48980347
30PLK31.47004027
31CHEK21.45861047
32PASK1.45411595
33STK161.45242380
34MKNK21.40580022
35STK101.40577636
36CDK41.37422941
37TNIK1.37060281
38SCYL21.35865424
39PDK41.35836799
40PDK31.35836799
41MAP3K81.34810872
42VRK11.33932293
43CCNB11.33845637
44CHEK11.29962247
45EPHA21.29428384
46EEF2K1.23030192
47AURKA1.22464528
48TAF11.20453552
49TRIM281.19260712
50FRK1.17819826
51MAP4K11.13690692
52WNK41.11169882
53MAP4K21.08216424
54ATM0.99125883
55TGFBR10.98520741
56STK40.96624333
57ALK0.94350720
58TESK10.93566158
59ZAK0.91198324
60CDK20.90582468
61MAP3K100.89721576
62PIM10.87239283
63WNK30.85582238
64PAK40.82863542
65CSNK2A20.81396386
66CDK190.79882334
67BRSK10.77810180
68PIM20.74940756
69PKN20.73725980
70CDK60.73405886
71CDK30.72120516
72BLK0.70740120
73PBK0.69753752
74PDK20.68779686
75CSNK2A10.68545456
76BRD40.65817009
77STK390.64164795
78MELK0.63938877
79PLK20.61528179
80CDK10.60177968
81OXSR10.59987611
82STK30.59801486
83KDR0.57421083
84CLK10.57232433
85EIF2AK20.57052978
86PAK10.56969040
87FLT30.55268110
88CDK80.55239316
89LRRK20.54825845
90ZAP700.52980319
91RPS6KA50.51615354
92MAP2K30.49697061
93CSNK1E0.47932830
94CSNK1G10.47912683
95ERBB30.47463097
96CAMK1G0.46561365
97ADRBK20.45042813
98NME10.44104356
99BCR0.43898209
100JAK30.43392166
101TEC0.42824613
102TXK0.42206984
103AKT30.41496262
104BRAF0.41203127
105NEK90.39701494
106INSRR0.37175804
107PRKDC0.36821242
108MTOR0.36589710
109PRKCI0.35774594
110GRK60.34858075
111BTK0.34506541
112MST40.34346077
113CSNK1G30.34331488
114GRK10.34187779
115CDK90.33382591
116ERBB40.33122712
117NEK60.30177322
118DMPK0.29468630
119BCKDK0.28631051
120STK38L0.27714022
121GSK3B0.27604238
122MAP3K30.26766218
123CSNK1G20.26595759
124MAPKAPK30.25202920
125MARK30.23659867
126DYRK20.23188033
127AKT20.23149321
128MAP3K110.23056863
129MAPK140.22828639
130LATS10.22798237
131ILK0.22599007
132MAP3K50.22188855
133NLK0.21501441
134CSNK1D0.20732236

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.67013172
2Mismatch repair_Homo sapiens_hsa034303.97654770
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.95874561
4Ribosome_Homo sapiens_hsa030103.53138870
5Spliceosome_Homo sapiens_hsa030403.43109794
6RNA transport_Homo sapiens_hsa030133.36558366
7Proteasome_Homo sapiens_hsa030503.25455304
8RNA polymerase_Homo sapiens_hsa030203.14955017
9Homologous recombination_Homo sapiens_hsa034402.91092830
10Base excision repair_Homo sapiens_hsa034102.80198560
11Nucleotide excision repair_Homo sapiens_hsa034202.75464680
12Cell cycle_Homo sapiens_hsa041102.69994529
13One carbon pool by folate_Homo sapiens_hsa006702.43992121
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38917713
15Pyrimidine metabolism_Homo sapiens_hsa002402.36300886
16Fanconi anemia pathway_Homo sapiens_hsa034602.24251594
17Oxidative phosphorylation_Homo sapiens_hsa001902.17305209
18Non-homologous end-joining_Homo sapiens_hsa034502.10071025
19Basal transcription factors_Homo sapiens_hsa030222.00918821
20Parkinsons disease_Homo sapiens_hsa050121.94447491
21RNA degradation_Homo sapiens_hsa030181.93296658
22mRNA surveillance pathway_Homo sapiens_hsa030151.91729411
23p53 signaling pathway_Homo sapiens_hsa041151.63361908
24Epstein-Barr virus infection_Homo sapiens_hsa051691.34804715
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33962511
26Antigen processing and presentation_Homo sapiens_hsa046121.30708784
27Purine metabolism_Homo sapiens_hsa002301.23474713
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19159857
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18911632
30Systemic lupus erythematosus_Homo sapiens_hsa053221.17392478
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16848678
32Herpes simplex infection_Homo sapiens_hsa051681.15634810
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12116341
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07602669
35Alzheimers disease_Homo sapiens_hsa050101.06860660
36Oocyte meiosis_Homo sapiens_hsa041141.04586644
37Viral carcinogenesis_Homo sapiens_hsa052031.03104304
38Propanoate metabolism_Homo sapiens_hsa006400.99553186
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94105969
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90418296
41Pentose phosphate pathway_Homo sapiens_hsa000300.87820004
42HTLV-I infection_Homo sapiens_hsa051660.83858771
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82576604
44Pyruvate metabolism_Homo sapiens_hsa006200.80419728
45Vitamin B6 metabolism_Homo sapiens_hsa007500.79225659
46Primary immunodeficiency_Homo sapiens_hsa053400.76568771
47Legionellosis_Homo sapiens_hsa051340.73311456
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.73214752
49Thyroid cancer_Homo sapiens_hsa052160.73103475
50Phototransduction_Homo sapiens_hsa047440.71531934
51Selenocompound metabolism_Homo sapiens_hsa004500.70090959
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67724135
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66412189
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.65986566
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65446134
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63256912
57Small cell lung cancer_Homo sapiens_hsa052220.62602722
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.61771767
59Measles_Homo sapiens_hsa051620.61338138
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61071930
61MicroRNAs in cancer_Homo sapiens_hsa052060.60399708
62Folate biosynthesis_Homo sapiens_hsa007900.56156942
63Steroid biosynthesis_Homo sapiens_hsa001000.55201810
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55065438
65Metabolic pathways_Homo sapiens_hsa011000.54703329
66Butanoate metabolism_Homo sapiens_hsa006500.54696476
67Apoptosis_Homo sapiens_hsa042100.54184186
68Nitrogen metabolism_Homo sapiens_hsa009100.53296587
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53112825
70Biosynthesis of amino acids_Homo sapiens_hsa012300.52367191
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50476168
72Cardiac muscle contraction_Homo sapiens_hsa042600.50340636
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49848834
74Sulfur relay system_Homo sapiens_hsa041220.48843797
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.47358807
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47298813
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46886645
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46233846
79Huntingtons disease_Homo sapiens_hsa050160.45961807
80Protein export_Homo sapiens_hsa030600.45856919
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45726926
82Hepatitis B_Homo sapiens_hsa051610.45633895
83Caffeine metabolism_Homo sapiens_hsa002320.44151336
84Influenza A_Homo sapiens_hsa051640.42062639
85Shigellosis_Homo sapiens_hsa051310.41779699
86Colorectal cancer_Homo sapiens_hsa052100.40147415
87Regulation of autophagy_Homo sapiens_hsa041400.39629501
88Lysine degradation_Homo sapiens_hsa003100.38385516
89Sulfur metabolism_Homo sapiens_hsa009200.37783136
90TGF-beta signaling pathway_Homo sapiens_hsa043500.37462451
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.36337593
92HIF-1 signaling pathway_Homo sapiens_hsa040660.35247565
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35015778
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33512412
95Alcoholism_Homo sapiens_hsa050340.33409345
96Viral myocarditis_Homo sapiens_hsa054160.33037142
97Hematopoietic cell lineage_Homo sapiens_hsa046400.32634890
98Allograft rejection_Homo sapiens_hsa053300.32544597
99T cell receptor signaling pathway_Homo sapiens_hsa046600.31832158
100Fatty acid elongation_Homo sapiens_hsa000620.31786690
101B cell receptor signaling pathway_Homo sapiens_hsa046620.31206555
102Acute myeloid leukemia_Homo sapiens_hsa052210.30814464
103Chronic myeloid leukemia_Homo sapiens_hsa052200.30807885
104Olfactory transduction_Homo sapiens_hsa047400.30670053
105Glutathione metabolism_Homo sapiens_hsa004800.30282785
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30199893
107Leishmaniasis_Homo sapiens_hsa051400.30049776
108Peroxisome_Homo sapiens_hsa041460.29395590
109Hippo signaling pathway_Homo sapiens_hsa043900.27163614
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.27077676
111Carbon metabolism_Homo sapiens_hsa012000.26584897
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25276362
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.24746357
114Asthma_Homo sapiens_hsa053100.23748936
115Pathways in cancer_Homo sapiens_hsa052000.23586655
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.23294111
117Vitamin digestion and absorption_Homo sapiens_hsa049770.23133394
118Prostate cancer_Homo sapiens_hsa052150.22315888
119Fructose and mannose metabolism_Homo sapiens_hsa000510.22314645
120Renin-angiotensin system_Homo sapiens_hsa046140.22156825
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21147120
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21144616
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21099165
124Adherens junction_Homo sapiens_hsa045200.20372269
125mTOR signaling pathway_Homo sapiens_hsa041500.19662025
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19137555
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18657092
128N-Glycan biosynthesis_Homo sapiens_hsa005100.18379760
129Circadian rhythm_Homo sapiens_hsa047100.17773639
130Notch signaling pathway_Homo sapiens_hsa043300.17521902
131Graft-versus-host disease_Homo sapiens_hsa053320.15646727
132Bladder cancer_Homo sapiens_hsa052190.14955254
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14826663
134Tryptophan metabolism_Homo sapiens_hsa003800.14811435
135Linoleic acid metabolism_Homo sapiens_hsa005910.14491894
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13974908
137Non-small cell lung cancer_Homo sapiens_hsa052230.13922178
138Toxoplasmosis_Homo sapiens_hsa051450.13769367
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13372112
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.13130469
141FoxO signaling pathway_Homo sapiens_hsa040680.13104588
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12206135
143Retinol metabolism_Homo sapiens_hsa008300.08077374
144Chemical carcinogenesis_Homo sapiens_hsa052040.07310580
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06291154
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02266613
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.02252722
148Wnt signaling pathway_Homo sapiens_hsa043100.01120634
149Ether lipid metabolism_Homo sapiens_hsa005650.00624947

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »