DNAJC16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.82281669
2synaptic vesicle maturation (GO:0016188)4.70356433
3locomotory exploration behavior (GO:0035641)4.56585083
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22400395
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.10463984
6synaptic vesicle exocytosis (GO:0016079)3.99537869
7regulation of synaptic vesicle exocytosis (GO:2000300)3.95845206
8glutamate secretion (GO:0014047)3.86665022
9regulation of synapse structural plasticity (GO:0051823)3.86600569
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83328410
11vocalization behavior (GO:0071625)3.77545661
12sodium ion export (GO:0071436)3.77364446
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.74216967
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.73479154
15regulation of glutamate receptor signaling pathway (GO:1900449)3.67079396
16cellular potassium ion homeostasis (GO:0030007)3.64958039
17layer formation in cerebral cortex (GO:0021819)3.64554773
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61360923
19response to pheromone (GO:0019236)3.61028972
20platelet dense granule organization (GO:0060155)3.60837226
21regulation of glucokinase activity (GO:0033131)3.60516572
22regulation of hexokinase activity (GO:1903299)3.60516572
23respiratory chain complex IV assembly (GO:0008535)3.59953724
24cellular ketone body metabolic process (GO:0046950)3.57876186
25regulation of synaptic vesicle transport (GO:1902803)3.56246959
26activation of protein kinase A activity (GO:0034199)3.54794885
27cell communication by electrical coupling (GO:0010644)3.47017047
28neurotransmitter secretion (GO:0007269)3.46694248
29inositol phosphate catabolic process (GO:0071545)3.45999877
30regulation of neuronal synaptic plasticity (GO:0048168)3.44483927
31lactate metabolic process (GO:0006089)3.43040182
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41328812
33dendritic spine morphogenesis (GO:0060997)3.37569180
34ketone body metabolic process (GO:1902224)3.36980589
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.30690692
36regulation of ARF protein signal transduction (GO:0032012)3.30024786
37exploration behavior (GO:0035640)3.27113045
38cytochrome complex assembly (GO:0017004)3.26282001
39water-soluble vitamin biosynthetic process (GO:0042364)3.24060779
40DNA double-strand break processing (GO:0000729)3.18002442
41neuronal action potential propagation (GO:0019227)3.15697007
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.12466283
43L-fucose catabolic process (GO:0042355)3.10398424
44fucose catabolic process (GO:0019317)3.10398424
45L-fucose metabolic process (GO:0042354)3.10398424
46cell communication involved in cardiac conduction (GO:0086065)3.09805184
47protein K11-linked deubiquitination (GO:0035871)3.09433510
48long-term memory (GO:0007616)3.08506363
49gamma-aminobutyric acid transport (GO:0015812)3.06952635
50establishment of nucleus localization (GO:0040023)3.05515181
51polyol catabolic process (GO:0046174)3.05103965
52keratinocyte development (GO:0003334)3.04152885
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01125475
54membrane depolarization during action potential (GO:0086010)2.99580244
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98820763
56signal peptide processing (GO:0006465)2.98045822
57phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98016788
58inositol phosphate dephosphorylation (GO:0046855)2.98016788
59axoneme assembly (GO:0035082)2.97868557
60proline transport (GO:0015824)2.94370079
61regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.93556013
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93419679
63regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93045367
64cytoskeletal anchoring at plasma membrane (GO:0007016)2.92909013
65nerve growth factor signaling pathway (GO:0038180)2.92024354
66branched-chain amino acid catabolic process (GO:0009083)2.91837934
67neuromuscular process controlling balance (GO:0050885)2.91517173
68dopamine transport (GO:0015872)2.86801265
69protein localization to synapse (GO:0035418)2.85508376
70potassium ion import (GO:0010107)2.85495272
71synapsis (GO:0007129)2.85263901
72axonal fasciculation (GO:0007413)2.83825610
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81831487
74negative regulation of translation, ncRNA-mediated (GO:0040033)2.81831487
75regulation of translation, ncRNA-mediated (GO:0045974)2.81831487
76prepulse inhibition (GO:0060134)2.80388447
77striatum development (GO:0021756)2.80231038
78neurotransmitter-gated ion channel clustering (GO:0072578)2.77424367
79negative regulation of execution phase of apoptosis (GO:1900118)2.77406469
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76763263
81regulation of acrosome reaction (GO:0060046)2.76623776
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.76094252
83membrane repolarization (GO:0086009)2.75636951
84epithelial cilium movement (GO:0003351)2.75573141
85prenylation (GO:0097354)2.75199993
86protein prenylation (GO:0018342)2.75199993
87synaptic transmission, glutamatergic (GO:0035249)2.74199834
88positive regulation of protein autophosphorylation (GO:0031954)2.73832877
89cerebellar Purkinje cell layer development (GO:0021680)2.73647475
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73606234
91cerebellar Purkinje cell differentiation (GO:0021702)2.73130523
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72453170
93positive regulation of synapse maturation (GO:0090129)2.72390578
94piRNA metabolic process (GO:0034587)2.71475132
95mating behavior (GO:0007617)2.70858757
96neuron recognition (GO:0008038)2.70662168
97regulation of dendritic spine morphogenesis (GO:0061001)2.70138491
98potassium ion homeostasis (GO:0055075)2.69581769
99regulation of membrane repolarization (GO:0060306)2.69192146
100neurotransmitter transport (GO:0006836)2.68958365
101neuromuscular process controlling posture (GO:0050884)2.68638217
102regulation of synaptic plasticity (GO:0048167)2.68598139
103positive regulation of membrane potential (GO:0045838)2.68071397
104positive regulation of potassium ion transmembrane transport (GO:1901381)2.67491792
105cilium morphogenesis (GO:0060271)2.67252438
106regulation of Rac protein signal transduction (GO:0035020)2.66973408
107regulation of clathrin-mediated endocytosis (GO:2000369)2.66823391
108glutamate receptor signaling pathway (GO:0007215)2.66666498
109dendrite morphogenesis (GO:0048813)2.64813448
110S-adenosylmethionine metabolic process (GO:0046500)2.64735398
111positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63633083
112neuron cell-cell adhesion (GO:0007158)2.63477474
113kidney morphogenesis (GO:0060993)2.63320505
114regulation of protein glycosylation (GO:0060049)2.62283653
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62105815
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.60521407
117zinc ion transport (GO:0006829)2.60298591
118regulation of postsynaptic membrane potential (GO:0060078)2.60125550
119cellular sodium ion homeostasis (GO:0006883)2.60120862
120neuron-neuron synaptic transmission (GO:0007270)2.59960902
121magnesium ion transport (GO:0015693)2.59853376
122detection of calcium ion (GO:0005513)2.59077594
123regulation of ARF GTPase activity (GO:0032312)2.58680550
124vesicle transport along microtubule (GO:0047496)2.58238184
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.57277520
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57125673
127epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56925854
128regulation of neurotransmitter levels (GO:0001505)2.55587767
129glycine transport (GO:0015816)2.54499721
130proteasome assembly (GO:0043248)2.53872202
131regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.53431051
132cardiac conduction (GO:0061337)2.52599075
133positive regulation of glycolytic process (GO:0045821)2.51712276
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51324450
135cilium organization (GO:0044782)2.50948198
136intraciliary transport (GO:0042073)2.50657569
137peptidyl-cysteine modification (GO:0018198)2.50585463
138response to auditory stimulus (GO:0010996)2.50259054
139membrane depolarization (GO:0051899)2.50053879
140negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50036658
141cilium assembly (GO:0042384)2.49313692
142synaptic vesicle endocytosis (GO:0048488)2.48818844
143membrane repolarization during action potential (GO:0086011)2.46929494
144positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.46834338
145nucleotide transmembrane transport (GO:1901679)2.46308132
146regulation of heart rate by cardiac conduction (GO:0086091)2.46283017
147alanine transport (GO:0032328)2.46160085
148tryptophan catabolic process (GO:0006569)2.46130838
149indole-containing compound catabolic process (GO:0042436)2.46130838
150indolalkylamine catabolic process (GO:0046218)2.46130838
151replication fork processing (GO:0031297)2.46097418
152protein localization to cilium (GO:0061512)2.45232241
153positive regulation of sodium ion transport (GO:0010765)2.44667791
154establishment of protein localization to Golgi (GO:0072600)2.44613056
155auditory behavior (GO:0031223)2.43501702
156regulation of calcium ion transmembrane transporter activity (GO:1901019)2.43423783
157regulation of calcium ion transmembrane transport (GO:1903169)2.43423783
158neural tube formation (GO:0001841)2.43014899
159chemosensory behavior (GO:0007635)2.42873704
160ventricular cardiac muscle cell action potential (GO:0086005)2.42631524
161renal tubule morphogenesis (GO:0061333)2.42535074
162intestinal epithelial cell development (GO:0060576)2.42443043
163preassembly of GPI anchor in ER membrane (GO:0016254)2.41760469
164cilium movement (GO:0003341)2.40214733
165pancreas development (GO:0031016)2.40192763
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39028555
167cullin deneddylation (GO:0010388)2.38254556
168regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.37915969
169photoreceptor cell maintenance (GO:0045494)2.37732264
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.37718757
171parental behavior (GO:0060746)2.37257501
172maturation of 5.8S rRNA (GO:0000460)2.37185708
173regulation of meiosis I (GO:0060631)2.37127129
174atrial cardiac muscle cell action potential (GO:0086014)2.36370766
175reflex (GO:0060004)2.36007678
176nephron tubule morphogenesis (GO:0072078)2.35237227
177nephron epithelium morphogenesis (GO:0072088)2.35237227
178heme transport (GO:0015886)2.35089496
179indolalkylamine metabolic process (GO:0006586)2.34827597
180L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32311582
181UDP-N-acetylglucosamine metabolic process (GO:0006047)2.32231064
182somite rostral/caudal axis specification (GO:0032525)2.31907402
183prostate gland growth (GO:0060736)2.31842224
184protein targeting to Golgi (GO:0000042)2.31637495
185negative regulation of JUN kinase activity (GO:0043508)2.31492328
186reciprocal meiotic recombination (GO:0007131)2.30265632
187reciprocal DNA recombination (GO:0035825)2.30265632
188detection of light stimulus involved in visual perception (GO:0050908)2.29895696
189detection of light stimulus involved in sensory perception (GO:0050962)2.29895696
190retinal cone cell development (GO:0046549)2.29802421
191insulin secretion (GO:0030073)2.29545427
192mitochondrial DNA replication (GO:0006264)2.29330093
193regulation of mesoderm development (GO:2000380)2.28464495
194regulation of neurotransmitter uptake (GO:0051580)2.28368750
195rRNA methylation (GO:0031167)2.27351483
196aromatic amino acid family catabolic process (GO:0009074)2.27212109
197positive regulation of actin filament depolymerization (GO:0030836)2.26953838
198behavioral response to nicotine (GO:0035095)2.26680676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50270014
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.01374415
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84567081
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.73151981
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.72855001
6DROSHA_22980978_ChIP-Seq_HELA_Human2.72021712
7VDR_22108803_ChIP-Seq_LS180_Human2.67944712
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60212444
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.58475669
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.57742526
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38231236
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37330985
13IGF1R_20145208_ChIP-Seq_DFB_Human2.30592457
14FUS_26573619_Chip-Seq_HEK293_Human2.27642610
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25781115
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23313153
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23313153
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.23006284
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21802952
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21538592
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20494291
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19649162
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16166155
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13388742
25P300_19829295_ChIP-Seq_ESCs_Human2.12524063
26REST_21632747_ChIP-Seq_MESCs_Mouse2.10149946
27GBX2_23144817_ChIP-Seq_PC3_Human2.03800890
28EWS_26573619_Chip-Seq_HEK293_Human2.02386586
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96863643
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93044763
31TAF15_26573619_Chip-Seq_HEK293_Human1.92475893
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92205400
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.91266637
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.89942794
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88528401
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85266396
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.84213784
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75280941
39BCAT_22108803_ChIP-Seq_LS180_Human1.74392669
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.73201817
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73111282
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71136934
43ER_23166858_ChIP-Seq_MCF-7_Human1.69267695
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.68939597
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64636899
46KDM2B_26808549_Chip-Seq_K562_Human1.63410977
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62779193
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.61180949
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60627843
50AR_21572438_ChIP-Seq_LNCaP_Human1.59806345
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59426978
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57294475
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.56605575
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56114141
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.54921687
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54660376
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.53347856
58TCF4_23295773_ChIP-Seq_U87_Human1.50645538
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.48008945
60CBP_20019798_ChIP-Seq_JUKART_Human1.47413901
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47413901
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47357704
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46525716
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45196524
65AR_25329375_ChIP-Seq_VCAP_Human1.43735574
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.42045329
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41992455
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40734395
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40374418
70SOX2_19829295_ChIP-Seq_ESCs_Human1.40024837
71NANOG_19829295_ChIP-Seq_ESCs_Human1.40024837
72CDX2_22108803_ChIP-Seq_LS180_Human1.39482730
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38728720
74ELK1_19687146_ChIP-ChIP_HELA_Human1.36503701
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36458547
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36373462
77TCF4_22108803_ChIP-Seq_LS180_Human1.35990666
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35843449
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35436258
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35262575
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.35118085
82P53_22387025_ChIP-Seq_ESCs_Mouse1.34397079
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33481081
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.33191673
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31281704
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.30684210
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29965119
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29667589
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28205416
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27444985
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27027696
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26941215
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25936231
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24959141
95* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24161409
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.23521018
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23425401
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.22068049
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.20782903
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20597364
101SOX2_21211035_ChIP-Seq_LN229_Gbm1.19880003
102P300_18555785_Chip-Seq_ESCs_Mouse1.19815147
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19796864
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18336742
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.17891210
106RUNX2_22187159_ChIP-Seq_PCA_Human1.17165913
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.17043519
108AR_19668381_ChIP-Seq_PC3_Human1.17041983
109LXR_22292898_ChIP-Seq_THP-1_Human1.16435801
110RING1B_27294783_Chip-Seq_ESCs_Mouse1.15627504
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15460436
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14939207
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.14731933
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14539467
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.13924772
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13572296
117TP53_22573176_ChIP-Seq_HFKS_Human1.13463221
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12718616
119SMAD4_21799915_ChIP-Seq_A2780_Human1.11896481
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11547231
121CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10785554
122KDM2B_26808549_Chip-Seq_DND41_Human1.10614476
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10152349
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10066678
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.09344197
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07707792
127MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07651865
128EST1_17652178_ChIP-ChIP_JURKAT_Human1.06930273
129AHR_22903824_ChIP-Seq_MCF-7_Human1.06896334
130HTT_18923047_ChIP-ChIP_STHdh_Human1.06862318
131OCT4_18555785_Chip-Seq_ESCs_Mouse1.06595264
132ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06155173
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06144446
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05582461
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05258485
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05258485
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04721379
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04594856
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04594856
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04512254
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04091434
142STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03878487
143GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03733061
144ZNF263_19887448_ChIP-Seq_K562_Human1.03520527
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.03417455
146NMYC_18555785_Chip-Seq_ESCs_Mouse1.02927062
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02763922
148FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02557351
149TP53_16413492_ChIP-PET_HCT116_Human1.02504807
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02428458
151EP300_21415370_ChIP-Seq_HL-1_Mouse1.02135082
152CTCF_27219007_Chip-Seq_Bcells_Human1.01471515
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.01383967
154FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00963835
155FOXA1_25329375_ChIP-Seq_VCAP_Human1.00963835
156FOXA2_19822575_ChIP-Seq_HepG2_Human0.99542785
157* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99176370
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98304574
159TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98276163
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.97050456
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96468012
162* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95899583
163SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95816615
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93067759
165KDM2B_26808549_Chip-Seq_JURKAT_Human0.92746415
166RING1B_27294783_Chip-Seq_NPCs_Mouse0.91528901
167PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91411470
168EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91231841
169SMC4_20622854_ChIP-Seq_HELA_Human0.90140083
170CREB1_26743006_Chip-Seq_LNCaP_Human0.89041218
171KLF4_19829295_ChIP-Seq_ESCs_Human0.88835110
172LXR_22158963_ChIP-Seq_LIVER_Mouse0.88702024
173SMAD3_21741376_ChIP-Seq_HESCs_Human0.88249486
174ZNF274_21170338_ChIP-Seq_K562_Hela0.88020863
175* STAT3_23295773_ChIP-Seq_U87_Human0.87898122
176CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86867401
177SMAD3_21741376_ChIP-Seq_EPCs_Human0.84748238
178TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84700321
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84560799
180CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84332495
181RXR_22108803_ChIP-Seq_LS180_Human0.84221268
182ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83470206
183MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82332986
184OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82140068
185YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81018716
186CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80343127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.93263028
2MP0003195_calcinosis4.85562161
3MP0003635_abnormal_synaptic_transmissio3.52350048
4MP0003880_abnormal_central_pattern3.26766816
5MP0000372_irregular_coat_pigmentation3.11378282
6MP0004270_analgesia3.07319647
7MP0008877_abnormal_DNA_methylation3.05183608
8MP0002063_abnormal_learning/memory/cond2.81195485
9MP0002064_seizures2.73499705
10MP0002837_dystrophic_cardiac_calcinosis2.69928281
11MP0002822_catalepsy2.69011892
12MP0006054_spinal_hemorrhage2.65831878
13MP0009745_abnormal_behavioral_response2.62788712
14MP0009046_muscle_twitch2.61008887
15MP0002102_abnormal_ear_morphology2.49019829
16MP0009780_abnormal_chondrocyte_physiolo2.36140875
17MP0003329_amyloid_beta_deposits2.30352609
18MP0000751_myopathy2.21398358
19MP0002572_abnormal_emotion/affect_behav2.19328391
20MP0001486_abnormal_startle_reflex2.17256120
21MP0002909_abnormal_adrenal_gland2.14170506
22MP0002272_abnormal_nervous_system2.09078653
23MP0001984_abnormal_olfaction2.01519416
24MP0005423_abnormal_somatic_nervous2.01277530
25MP0001968_abnormal_touch/_nociception1.95842610
26MP0008961_abnormal_basal_metabolism1.95770506
27MP0002254_reproductive_system_inflammat1.92884517
28MP0006072_abnormal_retinal_apoptosis1.91191294
29MP0002734_abnormal_mechanical_nocicepti1.90163727
30MP0005174_abnormal_tail_pigmentation1.89184105
31MP0000427_abnormal_hair_cycle1.86028052
32MP0001440_abnormal_grooming_behavior1.85360324
33MP0004858_abnormal_nervous_system1.82934966
34MP0003787_abnormal_imprinting1.82070631
35MP0001501_abnormal_sleep_pattern1.80201691
36MP0005379_endocrine/exocrine_gland_phen1.76829023
37MP0005253_abnormal_eye_physiology1.76533067
38MP0003950_abnormal_plasma_membrane1.66428820
39MP0000516_abnormal_urinary_system1.63640835
40MP0005367_renal/urinary_system_phenotyp1.63640835
41MP0004130_abnormal_muscle_cell1.63468253
42MP0002876_abnormal_thyroid_physiology1.62650895
43MP0002938_white_spotting1.62559322
44MP0008057_abnormal_DNA_replication1.61590665
45MP0003718_maternal_effect1.59994046
46MP0008569_lethality_at_weaning1.59564568
47MP0004811_abnormal_neuron_physiology1.55557399
48MP0002067_abnormal_sensory_capabilities1.53661315
49MP0003690_abnormal_glial_cell1.50324702
50MP0008875_abnormal_xenobiotic_pharmacok1.48591701
51MP0003646_muscle_fatigue1.46483058
52MP0004885_abnormal_endolymph1.46352898
53MP0005645_abnormal_hypothalamus_physiol1.46164447
54MP0000604_amyloidosis1.45175802
55MP0005075_abnormal_melanosome_morpholog1.44957841
56MP0001970_abnormal_pain_threshold1.44541991
57MP0005332_abnormal_amino_acid1.42937409
58MP0003633_abnormal_nervous_system1.40539346
59MP0004215_abnormal_myocardial_fiber1.40006832
60MP0003011_delayed_dark_adaptation1.39528745
61MP0010678_abnormal_skin_adnexa1.38635757
62MP0004924_abnormal_behavior1.38560670
63MP0005386_behavior/neurological_phenoty1.38560670
64MP0002736_abnormal_nociception_after1.37581722
65MP0002733_abnormal_thermal_nociception1.37514395
66MP0003879_abnormal_hair_cell1.36820887
67MP0002638_abnormal_pupillary_reflex1.36743586
68MP0004036_abnormal_muscle_relaxation1.35864103
69MP0000015_abnormal_ear_pigmentation1.35696202
70MP0010386_abnormal_urinary_bladder1.35026357
71MP0003890_abnormal_embryonic-extraembry1.34009183
72MP0004084_abnormal_cardiac_muscle1.32456251
73MP0000383_abnormal_hair_follicle1.32430250
74MP0002163_abnormal_gland_morphology1.32137623
75MP0002557_abnormal_social/conspecific_i1.31943659
76MP0005084_abnormal_gallbladder_morpholo1.31184690
77MP0002735_abnormal_chemical_nociception1.28759596
78MP0004147_increased_porphyrin_level1.28202537
79MP0008775_abnormal_heart_ventricle1.26570527
80MP0005187_abnormal_penis_morphology1.25503978
81MP0002184_abnormal_innervation1.24396480
82MP0005167_abnormal_blood-brain_barrier1.24093720
83MP0005395_other_phenotype1.23778059
84MP0003075_altered_response_to1.23197358
85MP0002066_abnormal_motor_capabilities/c1.22835428
86MP0000747_muscle_weakness1.22507189
87MP0003283_abnormal_digestive_organ1.21710997
88MP0000778_abnormal_nervous_system1.21646363
89MP0003122_maternal_imprinting1.20453458
90MP0003121_genomic_imprinting1.19853321
91MP0004233_abnormal_muscle_weight1.19851240
92MP0002168_other_aberrant_phenotype1.18508072
93MP0004085_abnormal_heartbeat1.18478609
94MP0003252_abnormal_bile_duct1.18186897
95MP0000955_abnormal_spinal_cord1.17085209
96MP0002882_abnormal_neuron_morphology1.16473779
97MP0005220_abnormal_exocrine_pancreas1.15958001
98MP0005408_hypopigmentation1.15548889
99MP0003172_abnormal_lysosome_physiology1.13876430
100MP0002090_abnormal_vision1.13241591
101MP0004510_myositis1.11200448
102MP0004145_abnormal_muscle_electrophysio1.11089714
103MP0003631_nervous_system_phenotype1.11017534
104MP0001502_abnormal_circadian_rhythm1.09528639
105MP0003137_abnormal_impulse_conducting1.09159429
106MP0001756_abnormal_urination1.08093938
107MP0010234_abnormal_vibrissa_follicle1.07535517
108MP0001944_abnormal_pancreas_morphology1.07468579
109MP0001485_abnormal_pinna_reflex1.07439601
110MP0006276_abnormal_autonomic_nervous1.06720215
111MP0005535_abnormal_body_temperature1.06431397
112MP0004133_heterotaxia1.06143255
113MP0008874_decreased_physiological_sensi1.06024054
114MP0000013_abnormal_adipose_tissue1.05623671
115MP0000647_abnormal_sebaceous_gland1.05210999
116MP0002229_neurodegeneration1.02216185
117MP0001324_abnormal_eye_pigmentation1.01219085
118MP0002693_abnormal_pancreas_physiology1.00419461
119MP0004043_abnormal_pH_regulation1.00414236
120MP0004087_abnormal_muscle_fiber1.00220766
121MP0003634_abnormal_glial_cell0.99088632
122MP0000920_abnormal_myelination0.98797231
123MP0002751_abnormal_autonomic_nervous0.98003807
124MP0002139_abnormal_hepatobiliary_system0.97716218
125MP0000538_abnormal_urinary_bladder0.97014103
126MP0000569_abnormal_digit_pigmentation0.95796175
127MP0002069_abnormal_eating/drinking_beha0.95299303
128MP0005623_abnormal_meninges_morphology0.94892534
129MP0001661_extended_life_span0.92829246
130MP0005646_abnormal_pituitary_gland0.91928888
131MP0008872_abnormal_physiological_respon0.91617937
132MP0003786_premature_aging0.91391492
133MP0009697_abnormal_copulation0.90539106
134MP0006036_abnormal_mitochondrial_physio0.90437698
135MP0002269_muscular_atrophy0.90220596
136MP0002152_abnormal_brain_morphology0.90047387
137MP0005636_abnormal_mineral_homeostasis0.89273531
138MP0000749_muscle_degeneration0.88762911
139MP0005620_abnormal_muscle_contractility0.88575551
140MP0004484_altered_response_of0.86929118
141MP0002160_abnormal_reproductive_system0.86080490
142MP0005330_cardiomyopathy0.85662055
143MP0005058_abnormal_lysosome_morphology0.85558660
144MP0003937_abnormal_limbs/digits/tail_de0.84656790
145MP0000003_abnormal_adipose_tissue0.83622671
146MP0010329_abnormal_lipoprotein_level0.82774019
147MP0002972_abnormal_cardiac_muscle0.81937392
148MP0005360_urolithiasis0.81905434
149MP0004019_abnormal_vitamin_homeostasis0.81800199
150MP0005551_abnormal_eye_electrophysiolog0.81271321
151MP0004134_abnormal_chest_morphology0.80953883
152MP0003943_abnormal_hepatobiliary_system0.80805377
153MP0000230_abnormal_systemic_arterial0.80634944
154MP0008058_abnormal_DNA_repair0.80621735
155MP0000631_abnormal_neuroendocrine_gland0.80540140
156MP0002095_abnormal_skin_pigmentation0.78192956
157MP0000371_diluted_coat_color0.78119217
158MP0005085_abnormal_gallbladder_physiolo0.76755607
159MP0000639_abnormal_adrenal_gland0.75818871
160MP0003045_fibrosis0.75792413
161MP0003632_abnormal_nervous_system0.75324224
162MP0004742_abnormal_vestibular_system0.74169537
163MP0002928_abnormal_bile_duct0.73993180
164MP0004142_abnormal_muscle_tone0.70338441
165MP0002118_abnormal_lipid_homeostasis0.69298466
166MP0001177_atelectasis0.68135553
167MP0005448_abnormal_energy_balance0.67640166

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.15948533
2Focal motor seizures (HP:0011153)5.11818231
3Focal seizures (HP:0007359)4.61915497
4Visual hallucinations (HP:0002367)3.85438560
5Supranuclear gaze palsy (HP:0000605)3.73424779
6Pancreatic cysts (HP:0001737)3.60455400
7Hypothermia (HP:0002045)3.46935293
8Ventricular fibrillation (HP:0001663)3.46089164
9Pancreatic fibrosis (HP:0100732)3.38127489
10Abnormality of midbrain morphology (HP:0002418)3.35889657
11Molar tooth sign on MRI (HP:0002419)3.35889657
12Progressive cerebellar ataxia (HP:0002073)3.31135239
13Action tremor (HP:0002345)3.24305724
14Abnormality of the renal cortex (HP:0011035)3.18430993
15Atonic seizures (HP:0010819)3.15089304
16Absence seizures (HP:0002121)3.13099319
17Sudden death (HP:0001699)3.10569362
18Renal cortical cysts (HP:0000803)3.03986522
19Depression (HP:0000716)3.03092798
20Dysmetric saccades (HP:0000641)3.03049203
21Postural instability (HP:0002172)3.00812520
22True hermaphroditism (HP:0010459)3.00805003
23Generalized tonic-clonic seizures (HP:0002069)2.99996493
24Cerebral inclusion bodies (HP:0100314)2.99085864
25Ankle clonus (HP:0011448)2.97915342
26Epileptic encephalopathy (HP:0200134)2.93917961
27Neurofibrillary tangles (HP:0002185)2.92764930
28Nephronophthisis (HP:0000090)2.89432996
29Large for gestational age (HP:0001520)2.88250570
30Abnormality of the lower motor neuron (HP:0002366)2.86857132
31Impaired social interactions (HP:0000735)2.82974654
32Abnormal social behavior (HP:0012433)2.82974654
33Insomnia (HP:0100785)2.82268382
34Bundle branch block (HP:0011710)2.81259151
35Exercise-induced myalgia (HP:0003738)2.81212124
36Intestinal atresia (HP:0011100)2.80663809
37Dialeptic seizures (HP:0011146)2.80153944
38Neoplasm of the adrenal cortex (HP:0100641)2.75696550
39Abnormality of the renal medulla (HP:0100957)2.71947619
40Congenital stationary night blindness (HP:0007642)2.69909954
41Impaired vibration sensation in the lower limbs (HP:0002166)2.68895023
42Dysdiadochokinesis (HP:0002075)2.68754976
43Ketoacidosis (HP:0001993)2.67651686
44Poor eye contact (HP:0000817)2.67542082
45Insidious onset (HP:0003587)2.67296949
46Termporal pattern (HP:0011008)2.67296949
47Dysmetria (HP:0001310)2.67005361
48Febrile seizures (HP:0002373)2.65801980
49Abnormal eating behavior (HP:0100738)2.64853403
50Medial flaring of the eyebrow (HP:0010747)2.60834299
51Urinary urgency (HP:0000012)2.59160898
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.58710477
53Hypoplasia of the fovea (HP:0007750)2.58710477
54Urinary bladder sphincter dysfunction (HP:0002839)2.55188001
55Methylmalonic acidemia (HP:0002912)2.54817927
56Intention tremor (HP:0002080)2.53561230
57Truncal ataxia (HP:0002078)2.52584441
58Pancreatic islet-cell hyperplasia (HP:0004510)2.52242246
59Syncope (HP:0001279)2.50312749
60Hemiplegia (HP:0002301)2.48234437
61Hyporeflexia of lower limbs (HP:0002600)2.47526746
62Prolonged QT interval (HP:0001657)2.45403837
63Status epilepticus (HP:0002133)2.42110305
64Progressive inability to walk (HP:0002505)2.41129148
65Torticollis (HP:0000473)2.40510340
66Spastic gait (HP:0002064)2.39464060
67Neoplasm of the adrenal gland (HP:0100631)2.38759204
68Central scotoma (HP:0000603)2.37579034
69Anxiety (HP:0000739)2.37348894
70Pheochromocytoma (HP:0002666)2.36947825
71Difficulty running (HP:0009046)2.36102231
72Abnormal drinking behavior (HP:0030082)2.35750644
73Polydipsia (HP:0001959)2.35750644
74Broad-based gait (HP:0002136)2.34546004
75Abnormality of vitamin B metabolism (HP:0004340)2.31915410
76Failure to thrive in infancy (HP:0001531)2.29645960
77Hypomagnesemia (HP:0002917)2.28363151
78Volvulus (HP:0002580)2.26218091
79Hamartoma of the eye (HP:0010568)2.25416607
80Hyperacusis (HP:0010780)2.24285515
81Gaze-evoked nystagmus (HP:0000640)2.21126405
82Genetic anticipation (HP:0003743)2.20836011
83Abnormal EKG (HP:0003115)2.19470253
84Furrowed tongue (HP:0000221)2.17992071
85Rapidly progressive (HP:0003678)2.17874044
86Attenuation of retinal blood vessels (HP:0007843)2.17719631
87Neuronal loss in central nervous system (HP:0002529)2.17440541
88Polyphagia (HP:0002591)2.17272861
89Focal dystonia (HP:0004373)2.17235950
90Global brain atrophy (HP:0002283)2.17037719
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.15567123
92Mutism (HP:0002300)2.15279803
93Chronic hepatic failure (HP:0100626)2.14943083
94Progressive macrocephaly (HP:0004481)2.14847220
95Aplasia/Hypoplasia of the tibia (HP:0005772)2.13864994
96Abnormality of the fovea (HP:0000493)2.09814830
97Calf muscle hypertrophy (HP:0008981)2.09113975
98Bradykinesia (HP:0002067)2.08483386
99Tubular atrophy (HP:0000092)2.07578052
100Metaphyseal dysplasia (HP:0100255)2.06935239
101Disproportionate short-trunk short stature (HP:0003521)2.06925097
102Type II lissencephaly (HP:0007260)2.06829312
103Hyperinsulinemic hypoglycemia (HP:0000825)2.06813658
104Inability to walk (HP:0002540)2.05775191
105Ventricular arrhythmia (HP:0004308)2.03586704
106Hyperglycemia (HP:0003074)2.03166405
107Hypoglycemic coma (HP:0001325)2.00136561
108Impaired smooth pursuit (HP:0007772)1.99968646
109Bifid tongue (HP:0010297)1.99836085
110Genital tract atresia (HP:0001827)1.99560378
111Abnormal biliary tract morphology (HP:0012440)1.99089558
112Proximal tubulopathy (HP:0000114)1.98690190
113Abnormality of the labia minora (HP:0012880)1.98501512
114Resting tremor (HP:0002322)1.98340160
115Papilledema (HP:0001085)1.97937079
116Lower limb muscle weakness (HP:0007340)1.97558583
117Abnormality of the astrocytes (HP:0100707)1.96542917
118Astrocytoma (HP:0009592)1.96542917
119Cystic liver disease (HP:0006706)1.96482122
120Fair hair (HP:0002286)1.96406520
121Methylmalonic aciduria (HP:0012120)1.95542043
122Craniofacial dystonia (HP:0012179)1.95385469
123Colon cancer (HP:0003003)1.94500551
124Pointed chin (HP:0000307)1.93130783
125Congenital primary aphakia (HP:0007707)1.93076713
126Neuroendocrine neoplasm (HP:0100634)1.92953256
127Hyperventilation (HP:0002883)1.92758437
128Abnormality of urine glucose concentration (HP:0011016)1.92447633
129Glycosuria (HP:0003076)1.92447633
130Albinism (HP:0001022)1.91098639
131Hemiparesis (HP:0001269)1.90617434
132Scanning speech (HP:0002168)1.90606899
133Elfin facies (HP:0004428)1.90238243
134Gait imbalance (HP:0002141)1.89678964
135Acute encephalopathy (HP:0006846)1.89261121
136Megalencephaly (HP:0001355)1.89153193
137Muscle hypertrophy of the lower extremities (HP:0008968)1.88913928
138Primary atrial arrhythmia (HP:0001692)1.88503042
139Abnormality of saccadic eye movements (HP:0000570)1.87082770
140Impaired vibratory sensation (HP:0002495)1.86845435
141Upper limb amyotrophy (HP:0009129)1.86129485
142Distal upper limb amyotrophy (HP:0007149)1.86129485
143Short tibia (HP:0005736)1.85346745
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85173016
145Polyuria (HP:0000103)1.85077902
146Ependymoma (HP:0002888)1.84697384
147Abolished electroretinogram (ERG) (HP:0000550)1.84667501
148Rigidity (HP:0002063)1.84652857
149Aqueductal stenosis (HP:0002410)1.83731429
150Abnormality of the pancreatic islet cells (HP:0006476)1.83207906
151Abnormality of endocrine pancreas physiology (HP:0012093)1.83207906
152Lower limb amyotrophy (HP:0007210)1.83012133
153Ketosis (HP:0001946)1.82546378
154Nephrogenic diabetes insipidus (HP:0009806)1.82444438
155EEG with generalized epileptiform discharges (HP:0011198)1.81796188
156Excessive salivation (HP:0003781)1.81309484
157Drooling (HP:0002307)1.81309484
158Epileptiform EEG discharges (HP:0011182)1.81004756
159Exercise-induced muscle cramps (HP:0003710)1.79454694
160Acute necrotizing encephalopathy (HP:0006965)1.79154704
161Thyroiditis (HP:0100646)1.79130584
162Macroorchidism (HP:0000053)1.79065553
163Amblyopia (HP:0000646)1.78574728
164Vaginal atresia (HP:0000148)1.78429690
165Clonus (HP:0002169)1.78314815
166Abnormality of the calf musculature (HP:0001430)1.78253477
167Glioma (HP:0009733)1.77685614
168Abnormality of ocular smooth pursuit (HP:0000617)1.77382716
169Stereotypic behavior (HP:0000733)1.76942698
170Abnormality of the Achilles tendon (HP:0005109)1.76548341
171Atrial fibrillation (HP:0005110)1.76192020
172Abnormality of macular pigmentation (HP:0008002)1.75700032
173Achilles tendon contracture (HP:0001771)1.75311637
174Heart block (HP:0012722)1.75182151
175Chorioretinal atrophy (HP:0000533)1.74774616
176Abnormality of the corticospinal tract (HP:0002492)1.74556901
177Tongue fasciculations (HP:0001308)1.74341788
178Widely spaced teeth (HP:0000687)1.74099809
179Delayed gross motor development (HP:0002194)1.73977454
180Increased CSF lactate (HP:0002490)1.73048477
181Biliary tract neoplasm (HP:0100574)1.73035841
182Popliteal pterygium (HP:0009756)1.73000645
183Hematochezia (HP:0002573)1.72054146
184Sensory axonal neuropathy (HP:0003390)1.70952767
185Tubulointerstitial nephritis (HP:0001970)1.70778676
186Postaxial hand polydactyly (HP:0001162)1.70701457
187Hypobetalipoproteinemia (HP:0003563)1.70040579
188Thyroid carcinoma (HP:0002890)1.70021094
189Abnormality of vitamin metabolism (HP:0100508)1.68212197
190Occipital encephalocele (HP:0002085)1.68133674
191Abnormality of methionine metabolism (HP:0010901)1.67998553
192Conjunctival hamartoma (HP:0100780)1.67929328
193Congenital hepatic fibrosis (HP:0002612)1.66763600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.07869646
2MAP3K93.56357233
3EPHA43.25365308
4NTRK33.15686650
5MST42.84742647
6ACVR1B2.74857095
7TRIM282.70863236
8WNK32.69190171
9PRKD32.58148350
10BMPR1B2.56178093
11PAK62.54713691
12DAPK22.51258510
13NUAK12.44324966
14MAP3K42.35501851
15TNIK2.26112753
16MKNK22.16618314
17EIF2AK32.16062782
18MAP4K22.14351931
19MARK12.12863846
20KSR21.99220018
21MINK11.98666907
22TRIB31.95209081
23PHKG21.94442029
24PHKG11.94442029
25GRK11.84429484
26MAP2K41.83834627
27TAF11.78880467
28CAMKK11.77054415
29NTRK21.71687718
30ADRBK21.68018690
31RIPK11.61938879
32LMTK21.57354075
33CASK1.54377131
34NTRK11.51432740
35STK381.49996684
36KSR11.45016675
37ERBB31.44747639
38CDK51.43793627
39PAK31.41667337
40BRSK21.41513318
41PLK31.38435471
42INSRR1.38113424
43TYRO31.38012569
44PKN21.36466191
45CAMK1G1.35041235
46STK31.33235564
47UHMK11.31907736
48RIPK41.28289739
49MKNK11.27614202
50MAP3K21.26373862
51STK38L1.25917989
52ZAK1.25017026
53SIK21.24299982
54ICK1.24285465
55TSSK61.20361379
56EIF2AK11.17816884
57PRKCH1.15691128
58NLK1.14398356
59MAP3K71.11413805
60MAP3K131.10634957
61DMPK1.09041941
62MAP3K121.08909923
63MAPK131.08570767
64RET1.04846220
65SGK4941.04675673
66SGK2231.04675673
67SCYL21.04380405
68ARAF1.03708312
69PRKCE1.01805467
70CSNK1G11.01758570
71PDK11.01070682
72MUSK1.00411861
73MAPKAPK30.99670209
74OBSCN0.99203809
75TTN0.98952876
76PDPK10.97216749
77CAMK1D0.95733291
78MAP2K70.94502451
79SGK30.94230706
80STK110.92649668
81TAOK10.92247801
82CAMK10.91614496
83AKT30.89467699
84BCR0.87466859
85TRPM70.86103069
86DAPK10.85757331
87FES0.85660982
88PDK40.82332028
89PDK30.82332028
90PRPF4B0.80635981
91PIK3CG0.78910168
92CSNK1G20.78259704
93ALK0.77959933
94STK240.77089222
95PRKCG0.76243257
96PNCK0.74902926
97SGK20.74731970
98PDGFRA0.73592570
99PTK2B0.73376204
100MARK20.72396742
101SGK10.72284905
102ADRBK10.71648725
103OXSR10.70617601
104TIE10.69858595
105CAMK2A0.69172980
106PRKCI0.69061277
107FGFR30.69013174
108PBK0.68938370
109MAPK120.68009400
110GRK50.67932051
111WNK40.66575990
112MAPKAPK50.66185663
113FGFR10.65071476
114MAP3K100.64845817
115PDK20.64599760
116MAP2K60.63830955
117MAP3K10.63720852
118SIK30.63231340
119PLK20.63068820
120CDK150.63033090
121TGFBR10.62525436
122WNK10.61748193
123CDK180.61603285
124NEK10.61368432
125FGFR20.60506819
126CSNK1G30.60238663
127WEE10.58832955
128CAMK40.58325198
129CDK140.58278561
130RAF10.57032197
131CSNK1A1L0.56311276
132PTK60.55891477
133FYN0.55677630
134PRKD10.55636612
135RPS6KA30.55323885
136PRKCZ0.55301895
137EPHB10.55098557
138CAMKK20.54038000
139NME10.53806007
140CDC42BPA0.53236544
141TEC0.51672893
142PRKAA10.51363437
143PKN10.50784732
144MAP2K10.50540505
145PRKAA20.49812889
146ERN10.49499048
147CDK11A0.48478631
148VRK10.47085280
149PINK10.47029243
150STK390.46876599
151ERBB20.46840642
152EIF2AK20.46712857
153CAMK2D0.46366766
154CAMK2B0.46151399
155FER0.46098593
156MAPK100.45450505
157ROCK10.38787836
158ATM0.34461826
159TLK10.34299655
160TAOK30.33259711
161MYLK0.30480824
162PLK10.30348369
163STK40.28493300
164PRKCQ0.27052703
165TGFBR20.26380777
166PRKG10.26370641
167YES10.26003722
168IGF1R0.25671834

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.30846306
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.78336215
3Olfactory transduction_Homo sapiens_hsa047402.39057939
4Synaptic vesicle cycle_Homo sapiens_hsa047212.34929953
5Nitrogen metabolism_Homo sapiens_hsa009102.28071911
6Nicotine addiction_Homo sapiens_hsa050332.27648941
7GABAergic synapse_Homo sapiens_hsa047272.07167557
8Circadian entrainment_Homo sapiens_hsa047132.05361134
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03186282
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00708131
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95506727
12Long-term potentiation_Homo sapiens_hsa047201.92933791
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92136122
14Vitamin B6 metabolism_Homo sapiens_hsa007501.90766562
15Sulfur metabolism_Homo sapiens_hsa009201.90663130
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90527373
17Glutamatergic synapse_Homo sapiens_hsa047241.87304753
18Caffeine metabolism_Homo sapiens_hsa002321.83784661
19Morphine addiction_Homo sapiens_hsa050321.82766156
20Tryptophan metabolism_Homo sapiens_hsa003801.75330510
21Proteasome_Homo sapiens_hsa030501.70871795
22Phototransduction_Homo sapiens_hsa047441.70710836
23Salivary secretion_Homo sapiens_hsa049701.68112444
24Basal transcription factors_Homo sapiens_hsa030221.66998755
25Gastric acid secretion_Homo sapiens_hsa049711.64555723
26Insulin secretion_Homo sapiens_hsa049111.63709517
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63670945
28Amphetamine addiction_Homo sapiens_hsa050311.63120586
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62214039
30Selenocompound metabolism_Homo sapiens_hsa004501.61005956
31Dopaminergic synapse_Homo sapiens_hsa047281.58561941
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56991803
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55013732
34Non-homologous end-joining_Homo sapiens_hsa034501.53396685
35Linoleic acid metabolism_Homo sapiens_hsa005911.52841569
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48011225
37Cholinergic synapse_Homo sapiens_hsa047251.44561052
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43482336
39Fatty acid elongation_Homo sapiens_hsa000621.42314206
40Renin secretion_Homo sapiens_hsa049241.40605865
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40383744
42RNA polymerase_Homo sapiens_hsa030201.39626714
43beta-Alanine metabolism_Homo sapiens_hsa004101.37500106
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35513482
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34880116
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34481714
47Retinol metabolism_Homo sapiens_hsa008301.33906928
48Ether lipid metabolism_Homo sapiens_hsa005651.33327108
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32173870
50Peroxisome_Homo sapiens_hsa041461.31601788
51Oxytocin signaling pathway_Homo sapiens_hsa049211.30789931
52Type II diabetes mellitus_Homo sapiens_hsa049301.29870548
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24149573
54GnRH signaling pathway_Homo sapiens_hsa049121.22205455
55Circadian rhythm_Homo sapiens_hsa047101.21689200
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21513158
57Homologous recombination_Homo sapiens_hsa034401.20612285
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18258021
59Steroid biosynthesis_Homo sapiens_hsa001001.17793583
60Calcium signaling pathway_Homo sapiens_hsa040201.17052898
61Dilated cardiomyopathy_Homo sapiens_hsa054141.16963738
62Chemical carcinogenesis_Homo sapiens_hsa052041.15319772
63Bile secretion_Homo sapiens_hsa049761.14106872
64Taste transduction_Homo sapiens_hsa047421.13106748
65Cocaine addiction_Homo sapiens_hsa050301.13077145
66Fanconi anemia pathway_Homo sapiens_hsa034601.13038215
67RNA degradation_Homo sapiens_hsa030181.12784239
68One carbon pool by folate_Homo sapiens_hsa006701.11809664
69Arginine biosynthesis_Homo sapiens_hsa002201.10956863
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10147413
71Sphingolipid metabolism_Homo sapiens_hsa006001.08406543
72cAMP signaling pathway_Homo sapiens_hsa040241.06355293
73Butanoate metabolism_Homo sapiens_hsa006501.05871062
74Gap junction_Homo sapiens_hsa045401.02438257
75Oxidative phosphorylation_Homo sapiens_hsa001901.01808258
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01074737
77ABC transporters_Homo sapiens_hsa020101.00602642
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99979460
79Long-term depression_Homo sapiens_hsa047300.99961353
80Estrogen signaling pathway_Homo sapiens_hsa049150.99822496
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98653236
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97460945
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97329945
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.97321981
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96966849
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96900089
87Glioma_Homo sapiens_hsa052140.96767493
88Cardiac muscle contraction_Homo sapiens_hsa042600.96536293
89Regulation of autophagy_Homo sapiens_hsa041400.94943970
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94192997
91Histidine metabolism_Homo sapiens_hsa003400.92382689
92Dorso-ventral axis formation_Homo sapiens_hsa043200.92202247
93ErbB signaling pathway_Homo sapiens_hsa040120.87064283
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85862617
95Serotonergic synapse_Homo sapiens_hsa047260.85491638
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84951183
97Collecting duct acid secretion_Homo sapiens_hsa049660.81061965
98Glucagon signaling pathway_Homo sapiens_hsa049220.80796957
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78363134
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.78027958
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77632891
102VEGF signaling pathway_Homo sapiens_hsa043700.75217798
103Melanogenesis_Homo sapiens_hsa049160.75191637
104Thyroid hormone synthesis_Homo sapiens_hsa049180.74480247
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.73865016
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73659037
107Fat digestion and absorption_Homo sapiens_hsa049750.72996833
108Axon guidance_Homo sapiens_hsa043600.72732979
109Fatty acid metabolism_Homo sapiens_hsa012120.72656014
110Pancreatic secretion_Homo sapiens_hsa049720.72002794
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.71998072
112Purine metabolism_Homo sapiens_hsa002300.71750098
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71011376
114Metabolic pathways_Homo sapiens_hsa011000.69984498
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69858959
116Parkinsons disease_Homo sapiens_hsa050120.69623981
117Insulin signaling pathway_Homo sapiens_hsa049100.68779239
118Fatty acid degradation_Homo sapiens_hsa000710.67885121
119Mineral absorption_Homo sapiens_hsa049780.67837449
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66890226
121mTOR signaling pathway_Homo sapiens_hsa041500.66178465
122Fatty acid biosynthesis_Homo sapiens_hsa000610.65052569
123Glutathione metabolism_Homo sapiens_hsa004800.63695175
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62896436
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62754267
126Lysine degradation_Homo sapiens_hsa003100.62683051
127Folate biosynthesis_Homo sapiens_hsa007900.61896123
128Prion diseases_Homo sapiens_hsa050200.61156540
129PPAR signaling pathway_Homo sapiens_hsa033200.59350122
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58946614
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.57977082
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.57951915
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57191719
134Propanoate metabolism_Homo sapiens_hsa006400.56904203
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56025022
136Endocytosis_Homo sapiens_hsa041440.55580354
137Pyruvate metabolism_Homo sapiens_hsa006200.55372694
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.55097392
139Choline metabolism in cancer_Homo sapiens_hsa052310.54816176
140Insulin resistance_Homo sapiens_hsa049310.54297492
141N-Glycan biosynthesis_Homo sapiens_hsa005100.53961969
142Arginine and proline metabolism_Homo sapiens_hsa003300.53895183
143Vitamin digestion and absorption_Homo sapiens_hsa049770.53816475
144Complement and coagulation cascades_Homo sapiens_hsa046100.53446284
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53243279
146MAPK signaling pathway_Homo sapiens_hsa040100.53202554
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52895115
148Renal cell carcinoma_Homo sapiens_hsa052110.51726394
149Arachidonic acid metabolism_Homo sapiens_hsa005900.51398015
150Endometrial cancer_Homo sapiens_hsa052130.50669371
151Non-small cell lung cancer_Homo sapiens_hsa052230.50138893
152Tyrosine metabolism_Homo sapiens_hsa003500.49622940
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47695710
154TGF-beta signaling pathway_Homo sapiens_hsa043500.47526661
155Vibrio cholerae infection_Homo sapiens_hsa051100.46389896
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.46134333
157Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45942459
158Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44179521
159Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43697048
160Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43544518
161Glycerolipid metabolism_Homo sapiens_hsa005610.42245770
162Starch and sucrose metabolism_Homo sapiens_hsa005000.41967162
163Inositol phosphate metabolism_Homo sapiens_hsa005620.41622867
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41104269
165Ovarian steroidogenesis_Homo sapiens_hsa049130.40938283
166Rap1 signaling pathway_Homo sapiens_hsa040150.40281137
167AMPK signaling pathway_Homo sapiens_hsa041520.40107168
168Carbon metabolism_Homo sapiens_hsa012000.37687971
169Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37426527
170Sphingolipid signaling pathway_Homo sapiens_hsa040710.36561710

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