DNAJC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine biosynthetic process (GO:0042416)4.77635121
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.76146145
3L-phenylalanine catabolic process (GO:0006559)4.76146145
4drug transmembrane transport (GO:0006855)4.73593794
5presynaptic membrane organization (GO:0097090)4.61400590
6dopamine transport (GO:0015872)4.55072140
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42586677
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.40731898
9L-phenylalanine metabolic process (GO:0006558)4.40731898
10water-soluble vitamin biosynthetic process (GO:0042364)4.31369183
11catecholamine biosynthetic process (GO:0042423)4.07076048
12catechol-containing compound biosynthetic process (GO:0009713)4.07076048
13glycerophospholipid catabolic process (GO:0046475)3.96412919
14inositol phosphate catabolic process (GO:0071545)3.93719532
15phosphorylated carbohydrate dephosphorylation (GO:0046838)3.84942217
16inositol phosphate dephosphorylation (GO:0046855)3.84942217
17urate metabolic process (GO:0046415)3.82190580
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70741874
19catecholamine transport (GO:0051937)3.68419245
20drug transport (GO:0015893)3.67729533
21toxin metabolic process (GO:0009404)3.67314861
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67240092
23respiratory chain complex IV assembly (GO:0008535)3.66960180
24indolalkylamine metabolic process (GO:0006586)3.65983115
25alkaloid metabolic process (GO:0009820)3.64044764
26aromatic amino acid family catabolic process (GO:0009074)3.59417995
27presynaptic membrane assembly (GO:0097105)3.57384938
28respiratory electron transport chain (GO:0022904)3.54391347
29electron transport chain (GO:0022900)3.51598036
30organic cation transport (GO:0015695)3.45658877
31energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.45058439
32ATP hydrolysis coupled proton transport (GO:0015991)3.45058439
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43813408
34ATP synthesis coupled proton transport (GO:0015986)3.43813408
35aromatic amino acid family metabolic process (GO:0009072)3.35345141
36monoamine transport (GO:0015844)3.33916676
37neurotransmitter biosynthetic process (GO:0042136)3.32750836
38mitochondrial respiratory chain complex assembly (GO:0033108)3.30947296
39serotonin metabolic process (GO:0042428)3.30137264
40positive regulation of amino acid transport (GO:0051957)3.29632496
41phenol-containing compound catabolic process (GO:0019336)3.28769553
42cytochrome complex assembly (GO:0017004)3.25077258
43transferrin transport (GO:0033572)3.23881791
44trivalent inorganic cation transport (GO:0072512)3.16667355
45ferric iron transport (GO:0015682)3.16667355
46regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16533841
47indole-containing compound metabolic process (GO:0042430)3.15940780
48Golgi transport vesicle coating (GO:0048200)3.11879972
49COPI coating of Golgi vesicle (GO:0048205)3.11879972
50aminoglycoside antibiotic metabolic process (GO:0030647)3.11441839
51regulation of hexokinase activity (GO:1903299)3.10627374
52regulation of glucokinase activity (GO:0033131)3.10627374
53dendritic spine morphogenesis (GO:0060997)3.09582620
54insulin secretion (GO:0030073)3.07859583
55succinate metabolic process (GO:0006105)3.07662632
56glycoside metabolic process (GO:0016137)3.07111069
57mannosylation (GO:0097502)3.06166802
58dopamine metabolic process (GO:0042417)3.04864602
59behavioral response to nicotine (GO:0035095)3.04134622
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03857135
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03669709
62neurotransmitter metabolic process (GO:0042133)3.02227858
63primary amino compound metabolic process (GO:1901160)2.98828250
64positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.98768308
65regulation of dopamine metabolic process (GO:0042053)2.97096069
66regulation of catecholamine metabolic process (GO:0042069)2.97096069
67cysteine metabolic process (GO:0006534)2.96902853
68peptide hormone processing (GO:0016486)2.96218230
69phenol-containing compound biosynthetic process (GO:0046189)2.95174415
70drug catabolic process (GO:0042737)2.93356337
71aldehyde catabolic process (GO:0046185)2.93336340
72polyol catabolic process (GO:0046174)2.92108963
73glyoxylate metabolic process (GO:0046487)2.90170633
74synaptic vesicle exocytosis (GO:0016079)2.89246574
75cellular ketone body metabolic process (GO:0046950)2.88240616
76protein localization to cilium (GO:0061512)2.87037312
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86945046
78NADH metabolic process (GO:0006734)2.86684394
79tyrosine metabolic process (GO:0006570)2.85890419
80neurotransmitter catabolic process (GO:0042135)2.85293767
81regulation of oxidative phosphorylation (GO:0002082)2.84790381
82coenzyme catabolic process (GO:0009109)2.81675121
83signal peptide processing (GO:0006465)2.80890978
84neurotransmitter secretion (GO:0007269)2.79461219
85protein complex biogenesis (GO:0070271)2.74243120
86purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72258121
873-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72258121
88exogenous drug catabolic process (GO:0042738)2.71368299
89endocrine pancreas development (GO:0031018)2.70827553
90lysine catabolic process (GO:0006554)2.70419008
91lysine metabolic process (GO:0006553)2.70419008
92tryptophan metabolic process (GO:0006568)2.70266609
93proline transport (GO:0015824)2.70149926
94phosphate ion transport (GO:0006817)2.70070343
95nitric oxide mediated signal transduction (GO:0007263)2.70048076
96lactate metabolic process (GO:0006089)2.69206162
97artery smooth muscle contraction (GO:0014824)2.69058299
98nonribosomal peptide biosynthetic process (GO:0019184)2.68790087
99cerebellar Purkinje cell layer development (GO:0021680)2.67561129
100oxaloacetate metabolic process (GO:0006107)2.65649845
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65481471
102proton transport (GO:0015992)2.64573399
103regulation of type B pancreatic cell apoptotic process (GO:2000674)2.63519767
104indole-containing compound catabolic process (GO:0042436)2.62977310
105indolalkylamine catabolic process (GO:0046218)2.62977310
106tryptophan catabolic process (GO:0006569)2.62977310
107hydrogen transport (GO:0006818)2.62710166
108positive regulation of peptide hormone secretion (GO:0090277)2.60953665
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60590355
110detection of calcium ion (GO:0005513)2.60563940
111response to pheromone (GO:0019236)2.59925714
112synaptic vesicle maturation (GO:0016188)2.59571430
113regulation of neurotransmitter uptake (GO:0051580)2.59132207
114branched-chain amino acid metabolic process (GO:0009081)2.58978098
115short-chain fatty acid metabolic process (GO:0046459)2.58660276
116glutamate secretion (GO:0014047)2.58316786
117nitric oxide biosynthetic process (GO:0006809)2.58093802
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.56991464
119hydrogen ion transmembrane transport (GO:1902600)2.56539733
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56363799
121positive regulation of peptide secretion (GO:0002793)2.55851456
122positive regulation of neurotransmitter transport (GO:0051590)2.55743368
123glutathione biosynthetic process (GO:0006750)2.55723233
124positive regulation of vesicle fusion (GO:0031340)2.55448032
125positive regulation of meiosis (GO:0045836)2.55246920
126positive regulation of insulin secretion (GO:0032024)2.55025786
127nucleobase catabolic process (GO:0046113)2.54190733
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.54148950
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.54131537
130neurofilament cytoskeleton organization (GO:0060052)2.53459947
131alanine transport (GO:0032328)2.53208279
132intraciliary transport (GO:0042073)2.51925937
133maternal behavior (GO:0042711)2.51267336
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49389584
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.49389584
136NADH dehydrogenase complex assembly (GO:0010257)2.49389584
137pteridine-containing compound biosynthetic process (GO:0042559)2.48386109
138protein localization to Golgi apparatus (GO:0034067)2.45807876
139phagosome maturation (GO:0090382)2.45574433
140regulation of mitochondrial translation (GO:0070129)2.45231851
141ER overload response (GO:0006983)2.44310475
142ketone body metabolic process (GO:1902224)2.43276941
143tricarboxylic acid metabolic process (GO:0072350)2.43234977
144glandular epithelial cell differentiation (GO:0002067)2.43030461
145neurotransmitter transport (GO:0006836)2.43024407
146axoneme assembly (GO:0035082)2.42638847
147righting reflex (GO:0060013)2.42039591
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40975327
149peptide hormone secretion (GO:0030072)2.40499383
150gamma-aminobutyric acid transport (GO:0015812)2.38793073
151negative regulation of membrane potential (GO:0045837)2.37941211
152regulation of insulin secretion (GO:0050796)2.37415775
153neuromuscular process controlling posture (GO:0050884)2.36341693
154calcium ion-dependent exocytosis (GO:0017156)2.36034089
155preassembly of GPI anchor in ER membrane (GO:0016254)2.35845045
156neuronal action potential (GO:0019228)2.35597908
157calcium ion import (GO:0070509)2.35410260
158membrane repolarization during action potential (GO:0086011)2.35171345
159positive regulation of meiotic cell cycle (GO:0051446)2.34304376
160positive regulation of histone H3-K4 methylation (GO:0051571)2.33782556
161regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.33737589
162regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.33737589
163regulation of acyl-CoA biosynthetic process (GO:0050812)2.31070251
164peptide secretion (GO:0002790)2.30138703
165auditory behavior (GO:0031223)2.29011685
166reflex (GO:0060004)2.28971287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01499513
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.71635820
3GBX2_23144817_ChIP-Seq_PC3_Human3.16456029
4VDR_22108803_ChIP-Seq_LS180_Human2.79182407
5TAF15_26573619_Chip-Seq_HEK293_Human2.56453089
6EZH2_22144423_ChIP-Seq_EOC_Human2.48784900
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.45295833
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31451878
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15851365
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14426994
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04863750
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96663535
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88258224
14PIAS1_25552417_ChIP-Seq_VCAP_Human1.86224900
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84895623
16* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82481674
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81824877
18IGF1R_20145208_ChIP-Seq_DFB_Human1.80759749
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76229445
20REST_21632747_ChIP-Seq_MESCs_Mouse1.73719223
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71342116
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71041766
23* P300_19829295_ChIP-Seq_ESCs_Human1.63944633
24SMAD4_21799915_ChIP-Seq_A2780_Human1.60586489
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.60443034
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.56747402
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55980931
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.55815818
29TP53_22573176_ChIP-Seq_HFKS_Human1.54584743
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48315029
31NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45818202
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45499344
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43869610
34EWS_26573619_Chip-Seq_HEK293_Human1.42357605
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41527992
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41498569
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41483733
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39245488
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38968827
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38826375
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38550351
42RNF2_27304074_Chip-Seq_NSC_Mouse1.38538418
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.35999732
44* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.35494289
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35177491
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34578166
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33483135
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32529895
49* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.31278369
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29890875
51ER_23166858_ChIP-Seq_MCF-7_Human1.29172026
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.28625482
53ZNF274_21170338_ChIP-Seq_K562_Hela1.26714466
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26101951
55* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25944818
56TCF4_23295773_ChIP-Seq_U87_Human1.23273656
57HTT_18923047_ChIP-ChIP_STHdh_Human1.22753463
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21650502
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20498964
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20226913
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18923307
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18078052
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16846633
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16570860
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16371660
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.16371660
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.14668507
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.13726187
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11929678
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11815683
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.11684992
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11196164
73LXR_22158963_ChIP-Seq_LIVER_Mouse1.10585588
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10382824
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10067140
76NANOG_19829295_ChIP-Seq_ESCs_Human1.09435944
77SOX2_19829295_ChIP-Seq_ESCs_Human1.09435944
78MYC_18940864_ChIP-ChIP_HL60_Human1.08081140
79REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07309159
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06131176
81STAT3_23295773_ChIP-Seq_U87_Human1.06111144
82* ETS1_20019798_ChIP-Seq_JURKAT_Human1.05113023
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.04853742
84FUS_26573619_Chip-Seq_HEK293_Human1.04654208
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04178633
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03972372
87TCF4_22108803_ChIP-Seq_LS180_Human1.03942428
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.03670915
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.03088383
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03061717
91* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02070590
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.00890443
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.00619601
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99967346
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99769158
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99230474
97* SRF_21415370_ChIP-Seq_HL-1_Mouse0.98860546
98EED_16625203_ChIP-ChIP_MESCs_Mouse0.98381318
99PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98222715
100BCAT_22108803_ChIP-Seq_LS180_Human0.97805965
101AR_25329375_ChIP-Seq_VCAP_Human0.97170712
102* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96620078
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96417199
104FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96236000
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96183573
106EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95958317
107RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95958317
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95177752
109CBP_20019798_ChIP-Seq_JUKART_Human0.95177752
110SOX2_18555785_Chip-Seq_ESCs_Mouse0.93476570
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93123153
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92706417
113STAT3_18555785_Chip-Seq_ESCs_Mouse0.92064594
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91981541
115RUNX2_22187159_ChIP-Seq_PCA_Human0.91388211
116P53_22387025_ChIP-Seq_ESCs_Mouse0.91380824
117* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.90813161
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.90694418
119KDM2B_26808549_Chip-Seq_REH_Human0.89906456
120NCOR_22424771_ChIP-Seq_293T_Human0.89800825
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88257771
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87571902
123JUN_21703547_ChIP-Seq_K562_Human0.86936248
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.86477802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.66366051
2MP0004043_abnormal_pH_regulation3.51650428
3MP0010386_abnormal_urinary_bladder3.44943540
4MP0005645_abnormal_hypothalamus_physiol3.44602672
5MP0003195_calcinosis3.22895564
6MP0003787_abnormal_imprinting3.13276398
7MP0005360_urolithiasis2.93984918
8MP0003122_maternal_imprinting2.92223756
9MP0006276_abnormal_autonomic_nervous2.92002130
10MP0008877_abnormal_DNA_methylation2.29319266
11MP0005332_abnormal_amino_acid2.26638213
12MP0002138_abnormal_hepatobiliary_system2.21042173
13MP0002638_abnormal_pupillary_reflex2.19624814
14MP0001905_abnormal_dopamine_level2.07769128
15MP0002909_abnormal_adrenal_gland2.07004412
16MP0005365_abnormal_bile_salt2.05329153
17MP0005379_endocrine/exocrine_gland_phen2.05255413
18MP0002876_abnormal_thyroid_physiology2.04606076
19MP0003183_abnormal_peptide_metabolism2.03959394
20MP0005084_abnormal_gallbladder_morpholo1.99151885
21MP0005535_abnormal_body_temperature1.98344918
22MP0001529_abnormal_vocalization1.98016295
23MP0008875_abnormal_xenobiotic_pharmacok1.96478347
24MP0003011_delayed_dark_adaptation1.96080863
25MP0002837_dystrophic_cardiac_calcinosis1.89933964
26MP0000538_abnormal_urinary_bladder1.85091079
27MP0000013_abnormal_adipose_tissue1.84478102
28MP0001765_abnormal_ion_homeostasis1.83590045
29MP0004019_abnormal_vitamin_homeostasis1.83553458
30MP0009046_muscle_twitch1.80765876
31MP0005085_abnormal_gallbladder_physiolo1.75084843
32MP0001756_abnormal_urination1.74566772
33MP0005220_abnormal_exocrine_pancreas1.74273216
34MP0003121_genomic_imprinting1.73600771
35MP0001501_abnormal_sleep_pattern1.73176651
36MP0005636_abnormal_mineral_homeostasis1.72512993
37MP0005646_abnormal_pituitary_gland1.71799485
38MP0001188_hyperpigmentation1.69867380
39MP0002735_abnormal_chemical_nociception1.66551584
40MP0002693_abnormal_pancreas_physiology1.65001151
41MP0009643_abnormal_urine_homeostasis1.64593280
42MP0002734_abnormal_mechanical_nocicepti1.62897804
43MP0003123_paternal_imprinting1.62746939
44MP0002064_seizures1.62345131
45MP0003283_abnormal_digestive_organ1.61305196
46MP0002822_catalepsy1.59164890
47MP0009745_abnormal_behavioral_response1.58706503
48MP0003635_abnormal_synaptic_transmissio1.52115341
49MP0001944_abnormal_pancreas_morphology1.51982271
50MP0004270_analgesia1.51178194
51MP0002733_abnormal_thermal_nociception1.50458989
52MP0006072_abnormal_retinal_apoptosis1.49607718
53MP0002572_abnormal_emotion/affect_behav1.49506558
54MP0002272_abnormal_nervous_system1.49137964
55MP0005253_abnormal_eye_physiology1.47292803
56MP0005423_abnormal_somatic_nervous1.42657730
57MP0003868_abnormal_feces_composition1.36644038
58MP0001502_abnormal_circadian_rhythm1.36000019
59MP0002078_abnormal_glucose_homeostasis1.35936335
60MP0001984_abnormal_olfaction1.35395834
61MP0004147_increased_porphyrin_level1.32227285
62MP0002163_abnormal_gland_morphology1.29925310
63MP0003959_abnormal_lean_body1.26578221
64MP0008872_abnormal_physiological_respon1.26392378
65MP0001970_abnormal_pain_threshold1.25313934
66MP0005058_abnormal_lysosome_morphology1.24937493
67MP0010329_abnormal_lipoprotein_level1.24511459
68MP0004885_abnormal_endolymph1.24426505
69MP0001764_abnormal_homeostasis1.24028083
70MP0001440_abnormal_grooming_behavior1.22662374
71MP0003880_abnormal_central_pattern1.22567448
72MP0002751_abnormal_autonomic_nervous1.21738285
73MP0002063_abnormal_learning/memory/cond1.21652268
74MP0004142_abnormal_muscle_tone1.18185711
75MP0004924_abnormal_behavior1.18151101
76MP0005386_behavior/neurological_phenoty1.18151101
77MP0002184_abnormal_innervation1.16626106
78MP0005551_abnormal_eye_electrophysiolog1.15197290
79MP0006036_abnormal_mitochondrial_physio1.14888609
80MP0001968_abnormal_touch/_nociception1.13899344
81MP0002557_abnormal_social/conspecific_i1.13298555
82MP0003953_abnormal_hormone_level1.12124323
83MP0003879_abnormal_hair_cell1.11733030
84MP0002067_abnormal_sensory_capabilities1.11532374
85MP0002160_abnormal_reproductive_system1.09780713
86MP0005448_abnormal_energy_balance1.07827359
87MP0005083_abnormal_biliary_tract1.02923810
88MP0009379_abnormal_foot_pigmentation1.00404464
89MP0000230_abnormal_systemic_arterial1.00088314
90MP0006292_abnormal_olfactory_placode0.99088846
91MP0002069_abnormal_eating/drinking_beha0.96909675
92MP0000631_abnormal_neuroendocrine_gland0.96639216
93MP0005408_hypopigmentation0.96507492
94MP0001986_abnormal_taste_sensitivity0.95123773
95MP0002928_abnormal_bile_duct0.94810056
96MP0004859_abnormal_synaptic_plasticity0.94644696
97MP0008995_early_reproductive_senescence0.94493169
98MP0002938_white_spotting0.94291987
99MP0006035_abnormal_mitochondrial_morpho0.92848295
100MP0003806_abnormal_nucleotide_metabolis0.90495289
101MP0002229_neurodegeneration0.90330911
102MP0002736_abnormal_nociception_after0.89859402
103MP0001664_abnormal_digestion0.89766215
104MP0003252_abnormal_bile_duct0.89559652
105MP0009780_abnormal_chondrocyte_physiolo0.88215482
106MP0004133_heterotaxia0.87572722
107MP0001666_abnormal_nutrient_absorption0.87361702
108MP0004215_abnormal_myocardial_fiber0.86973133
109MP0004085_abnormal_heartbeat0.84177356
110MP0010234_abnormal_vibrissa_follicle0.79096893
111MP0001485_abnormal_pinna_reflex0.78810315
112MP0002882_abnormal_neuron_morphology0.78583661
113MP0005389_reproductive_system_phenotype0.78059185
114MP0008961_abnormal_basal_metabolism0.77096435
115MP0002066_abnormal_motor_capabilities/c0.77093621
116MP0003633_abnormal_nervous_system0.75066754
117MP0002090_abnormal_vision0.74663933
118MP0000639_abnormal_adrenal_gland0.74331245
119MP0001486_abnormal_startle_reflex0.71690625
120MP0002118_abnormal_lipid_homeostasis0.71633327
121MP0002136_abnormal_kidney_physiology0.68089488
122MP0004742_abnormal_vestibular_system0.68070815

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)4.51934909
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32579844
3Pheochromocytoma (HP:0002666)4.22822189
4Hypothermia (HP:0002045)4.12068716
5Neuroendocrine neoplasm (HP:0100634)3.93590263
6Retinal atrophy (HP:0001105)3.69540817
7Increased circulating renin level (HP:0000848)3.64542748
8Hyperactive renin-angiotensin system (HP:0000841)3.63821728
9Ketoacidosis (HP:0001993)3.58281746
10Acute necrotizing encephalopathy (HP:0006965)3.53710904
11Hypomagnesemia (HP:0002917)3.48264533
12Acute encephalopathy (HP:0006846)3.45944300
13Limb dystonia (HP:0002451)3.43167661
14Abnormal mitochondria in muscle tissue (HP:0008316)3.34547253
15Large for gestational age (HP:0001520)3.28343573
16Hypokalemic alkalosis (HP:0001949)3.27048626
17Abnormality of chloride homeostasis (HP:0011422)3.24061186
18Abnormality of calcium-phosphate metabolism (HP:0100530)3.13682834
19Increased hepatocellular lipid droplets (HP:0006565)3.13061997
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.09546669
21Metabolic alkalosis (HP:0200114)3.07671995
22Abnormality of magnesium homeostasis (HP:0004921)3.07139867
23Polyuria (HP:0000103)3.01336713
24Progressive macrocephaly (HP:0004481)2.97325568
25Ketosis (HP:0001946)2.90475051
26Hypoglycemic seizures (HP:0002173)2.89512267
27Hypoglycemic coma (HP:0001325)2.87842646
28Abnormality of renin-angiotensin system (HP:0000847)2.87083472
29Symptomatic seizures (HP:0011145)2.83019437
30Abnormal urine output (HP:0012590)2.80837626
31Methylmalonic acidemia (HP:0002912)2.80037183
32Mitochondrial inheritance (HP:0001427)2.77886531
33Cerebral edema (HP:0002181)2.76646182
34Proximal tubulopathy (HP:0000114)2.74789469
35Hyperinsulinemic hypoglycemia (HP:0000825)2.73484127
36Alkalosis (HP:0001948)2.70773809
37Hyperglycemia (HP:0003074)2.69716487
38Glycosuria (HP:0003076)2.69420335
39Abnormality of urine glucose concentration (HP:0011016)2.69420335
40Abnormality of renal excretion (HP:0011036)2.68189680
41Polydipsia (HP:0001959)2.67325716
42Abnormal drinking behavior (HP:0030082)2.67325716
43Renal Fanconi syndrome (HP:0001994)2.65548657
44Generalized aminoaciduria (HP:0002909)2.64228015
45Febrile seizures (HP:0002373)2.63923886
46Hyperaldosteronism (HP:0000859)2.61590661
47Hyperglycinuria (HP:0003108)2.61361116
48Molar tooth sign on MRI (HP:0002419)2.60714046
49Abnormality of midbrain morphology (HP:0002418)2.60714046
50Hemiparesis (HP:0001269)2.60040632
51Hyperphosphaturia (HP:0003109)2.56689575
52Abnormal pupillary function (HP:0007686)2.55855297
53Intestinal atresia (HP:0011100)2.54200708
54Increased purine levels (HP:0004368)2.53310007
55Hyperuricemia (HP:0002149)2.53310007
56Hypokalemia (HP:0002900)2.52360438
57Abnormality of vitamin B metabolism (HP:0004340)2.51251838
58Congenital malformation of the right heart (HP:0011723)2.49269820
59Double outlet right ventricle (HP:0001719)2.49269820
60Polyphagia (HP:0002591)2.48283765
61Medial flaring of the eyebrow (HP:0010747)2.47922043
62Abnormality of purine metabolism (HP:0004352)2.46640231
63Hepatic necrosis (HP:0002605)2.44207064
64Gait imbalance (HP:0002141)2.43385991
65Tetany (HP:0001281)2.43246510
66Increased CSF lactate (HP:0002490)2.42525600
67Renal cortical cysts (HP:0000803)2.42299739
68Pancreatic fibrosis (HP:0100732)2.41910241
69Myokymia (HP:0002411)2.41723026
70Congenital primary aphakia (HP:0007707)2.40481412
71Agitation (HP:0000713)2.40126154
72Poor suck (HP:0002033)2.39693805
73Muscular hypotonia of the trunk (HP:0008936)2.39430061
74Nephrogenic diabetes insipidus (HP:0009806)2.39322894
753-Methylglutaconic aciduria (HP:0003535)2.38939328
76Hypokinesia (HP:0002375)2.36953899
77Abnormality of renal resorption (HP:0011038)2.36018953
78Decreased circulating renin level (HP:0003351)2.35233382
79Absence seizures (HP:0002121)2.34003446
80Retinal dysplasia (HP:0007973)2.32033615
81Oligomenorrhea (HP:0000876)2.31143890
82Hepatocellular necrosis (HP:0001404)2.29371113
83Dialeptic seizures (HP:0011146)2.28815596
84Gaze-evoked nystagmus (HP:0000640)2.27984611
85Diminished movement (HP:0002374)2.27773426
86Hyperthyroidism (HP:0000836)2.26683137
87Abnormality of the renal cortex (HP:0011035)2.25497042
88Nephronophthisis (HP:0000090)2.24084758
89Methylmalonic aciduria (HP:0012120)2.22517402
90Epileptic encephalopathy (HP:0200134)2.22094887
91Focal seizures (HP:0007359)2.20643192
92Abnormal urine phosphate concentration (HP:0012599)2.20173306
93Focal motor seizures (HP:0011153)2.19674768
94True hermaphroditism (HP:0010459)2.16794847
95Conjugated hyperbilirubinemia (HP:0002908)2.15768127
96Late onset (HP:0003584)2.14296089
97Lethargy (HP:0001254)2.14118388
98Failure to thrive in infancy (HP:0001531)2.13577285
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12848329
100Renal salt wasting (HP:0000127)2.12828950
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12195318
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12195318
103Abnormality of potassium homeostasis (HP:0011042)2.11185153
104Anxiety (HP:0000739)2.10470745
105Type II lissencephaly (HP:0007260)2.09764172
106Enlarged kidneys (HP:0000105)2.08670758
107Generalized tonic-clonic seizures (HP:0002069)2.06738659
108Limb hypertonia (HP:0002509)2.06738641
109Abnormality of serine family amino acid metabolism (HP:0010894)2.03586584
110Abnormality of glycine metabolism (HP:0010895)2.03586584
111Hyperglycinemia (HP:0002154)2.03300682
112Occipital encephalocele (HP:0002085)2.01206309
113Respiratory failure (HP:0002878)2.01083565
114Abnormality of vitamin metabolism (HP:0100508)2.00956037
115Lactic acidosis (HP:0003128)2.00358808
116EEG with generalized epileptiform discharges (HP:0011198)1.99504108
117Increased intramyocellular lipid droplets (HP:0012240)1.98909746
118Hypophosphatemia (HP:0002148)1.98002883
119Progressive cerebellar ataxia (HP:0002073)1.95642986
120Hypotension (HP:0002615)1.95407618
121Neoplasm of the adrenal gland (HP:0100631)1.94863511
122Congenital stationary night blindness (HP:0007642)1.92920294
123Furrowed tongue (HP:0000221)1.92617003
124Epileptiform EEG discharges (HP:0011182)1.92148176
125Atonic seizures (HP:0010819)1.91565140
126Vacuolated lymphocytes (HP:0001922)1.91038644
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90725343
128Degeneration of the lateral corticospinal tracts (HP:0002314)1.90725343
129Akinesia (HP:0002304)1.89312086
130Irritability (HP:0000737)1.89236878
131Tachypnea (HP:0002789)1.88203887
132Pancreatic cysts (HP:0001737)1.87453578
133Insulin-resistant diabetes mellitus (HP:0000831)1.87108643
134Postural tremor (HP:0002174)1.86732380
135Hypsarrhythmia (HP:0002521)1.86468177
136Vomiting (HP:0002013)1.85196783
137Adrenal overactivity (HP:0002717)1.84771947
138Exertional dyspnea (HP:0002875)1.82984158
139Hepatoblastoma (HP:0002884)1.82805574
140Vaginal atresia (HP:0000148)1.82354438
141Increased serum lactate (HP:0002151)1.80823119
142Metabolic acidosis (HP:0001942)1.80395899
143Cerebellar dysplasia (HP:0007033)1.79977589
144Genital tract atresia (HP:0001827)1.79343893
145Abnormality of the renal medulla (HP:0100957)1.78698391
146Dysautonomia (HP:0002459)1.78682881
147Abnormality of the corticospinal tract (HP:0002492)1.77932414
148Optic disc pallor (HP:0000543)1.77662707
149Lipid accumulation in hepatocytes (HP:0006561)1.77570974
150Fetal akinesia sequence (HP:0001989)1.75035006
151Abnormal eating behavior (HP:0100738)1.74710426
152Progressive inability to walk (HP:0002505)1.74269279
153Abnormal sex determination (HP:0012244)1.74250538
154Sex reversal (HP:0012245)1.74250538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.18029265
2WNK44.47025897
3MAPK152.96839952
4INSRR2.91761394
5OXSR12.80341974
6PNCK2.50399467
7MAP4K22.39998334
8DAPK22.20795706
9BCKDK2.15486676
10CSNK1G32.12760850
11FRK2.01936590
12MAP2K71.98431138
13FGFR21.92523177
14MST41.91340160
15PRPF4B1.89535528
16MAP3K121.82666438
17NTRK31.81988404
18STK161.80275120
19MAP3K41.80031499
20STK391.70051833
21GRK71.67470102
22CSNK1G21.63135511
23CASK1.59962672
24CSNK1G11.55734303
25NME11.49205881
26PIK3CG1.49015750
27MAP3K21.46630071
28GRK51.41767984
29CAMKK21.41099476
30ARAF1.31973386
31MAP2K41.31072935
32MAP3K91.27141229
33SGK4941.15318136
34SGK2231.15318136
35NTRK11.13636268
36ACVR1B1.13002209
37PRKD31.12627500
38PAK31.11762410
39IRAK11.11389399
40MINK11.11245896
41UHMK11.08098800
42DYRK21.07973284
43CSNK1A1L1.07022291
44MARK11.05751827
45STK38L1.04633764
46MAP2K61.00394259
47FGFR40.98671904
48BMPR1B0.96476629
49PINK10.93540050
50BCR0.93146378
51WNK10.92634178
52NTRK20.92014956
53ERBB40.89886145
54TRPM70.86848108
55TRIM280.86431736
56CAMK2G0.82445100
57MUSK0.82161666
58PRKCE0.82023520
59PRKCG0.80285723
60HIPK20.78602410
61TAOK30.78336900
62ADRBK20.77891668
63IRAK30.77244785
64SGK20.76358814
65PRKCI0.76195274
66CAMK2A0.75337527
67TLK10.74885710
68ZAK0.73785870
69FER0.72331242
70PLK20.68859402
71AKT30.68224448
72BMPR20.66496568
73DAPK10.65926650
74FES0.64370309
75ADRBK10.63278381
76IRAK20.62375624
77TIE10.60084693
78FGFR30.59771890
79CAMK1G0.59754377
80EPHA30.58503030
81MAPK130.58461560
82CAMK2D0.57753218
83CSNK1E0.56615460
84BRAF0.54384070
85PRKACA0.54306583
86NUAK10.53368800
87LIMK10.53173705
88MAP3K10.52893150
89CSNK1A10.51751008
90GRK10.51574684
91DYRK1A0.50930651
92PRKACB0.49473033
93ERBB30.48828296
94STK110.47475198
95MAPKAPK50.46743556
96CAMK2B0.46429775
97PASK0.46341469
98MAP3K30.45703940
99CAMK10.45444139
100MYLK0.44926198
101PDK20.44437555
102SCYL20.43708990
103PRKACG0.43621226
104PRKAA10.41625004
105TNIK0.40902039
106TNK20.40705646
107PRKCH0.40325054
108PRKCZ0.40142784
109CSNK1D0.39036617
110CDK50.38749094
111SGK10.38748724
112PAK60.38269461
113PLK30.38041492
114LATS10.38012400
115RPS6KA50.35362632
116EIF2AK30.34837015
117EIF2AK10.34559549
118CAMKK10.34294806
119EPHA40.34190859
120NLK0.34026429
121CDC42BPA0.32710884
122PHKG20.31804603
123PHKG10.31804603
124PRKCA0.31676697
125TSSK60.31288569
126STK380.31007811
127RPS6KB10.30864568
128MAP2K10.29768241
129PRKG10.29316000
130DYRK1B0.28654736
131PDK30.27946457
132PDK40.27946457
133CSNK2A20.27740956
134KSR10.26074176
135SGK30.25566797

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.76723548
2Sulfur metabolism_Homo sapiens_hsa009203.41407361
3Oxidative phosphorylation_Homo sapiens_hsa001903.26738342
4Collecting duct acid secretion_Homo sapiens_hsa049663.15935674
5Protein export_Homo sapiens_hsa030602.96450173
6Parkinsons disease_Homo sapiens_hsa050122.63173767
7Synaptic vesicle cycle_Homo sapiens_hsa047212.49209413
8Butanoate metabolism_Homo sapiens_hsa006502.29225530
9Vibrio cholerae infection_Homo sapiens_hsa051102.18088352
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17006889
11Tryptophan metabolism_Homo sapiens_hsa003802.05708435
12Phenylalanine metabolism_Homo sapiens_hsa003602.04752175
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.87897315
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80479320
15Alzheimers disease_Homo sapiens_hsa050101.77031740
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74473456
17Propanoate metabolism_Homo sapiens_hsa006401.72786586
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66765609
19Huntingtons disease_Homo sapiens_hsa050161.60731271
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58170520
21Pyruvate metabolism_Homo sapiens_hsa006201.56251310
22Histidine metabolism_Homo sapiens_hsa003401.56075986
23Cocaine addiction_Homo sapiens_hsa050301.56020686
24Vitamin B6 metabolism_Homo sapiens_hsa007501.55853720
25Insulin secretion_Homo sapiens_hsa049111.55851271
26Tyrosine metabolism_Homo sapiens_hsa003501.47595578
27Peroxisome_Homo sapiens_hsa041461.42397174
28Folate biosynthesis_Homo sapiens_hsa007901.40354222
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39936184
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33256658
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30530830
32GABAergic synapse_Homo sapiens_hsa047271.27582409
33Serotonergic synapse_Homo sapiens_hsa047261.25338191
34Nicotine addiction_Homo sapiens_hsa050331.23739918
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.14582152
36Amphetamine addiction_Homo sapiens_hsa050311.13335968
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13021332
38Regulation of autophagy_Homo sapiens_hsa041401.12838481
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12045601
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08098739
41Selenocompound metabolism_Homo sapiens_hsa004501.07917255
42Ether lipid metabolism_Homo sapiens_hsa005651.07865905
43Type I diabetes mellitus_Homo sapiens_hsa049401.07203630
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04759429
45beta-Alanine metabolism_Homo sapiens_hsa004101.02598631
46Taste transduction_Homo sapiens_hsa047421.02038041
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01056370
48Fatty acid degradation_Homo sapiens_hsa000710.99021411
49Fatty acid elongation_Homo sapiens_hsa000620.97874350
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97445796
51Nitrogen metabolism_Homo sapiens_hsa009100.96513026
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96180786
53Linoleic acid metabolism_Homo sapiens_hsa005910.95069517
54Basal transcription factors_Homo sapiens_hsa030220.93689777
55Cardiac muscle contraction_Homo sapiens_hsa042600.93328579
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92427248
57Caffeine metabolism_Homo sapiens_hsa002320.88307909
58Dopaminergic synapse_Homo sapiens_hsa047280.87842812
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87334541
60One carbon pool by folate_Homo sapiens_hsa006700.85075286
61Rheumatoid arthritis_Homo sapiens_hsa053230.82481101
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78808934
63Arginine and proline metabolism_Homo sapiens_hsa003300.78571386
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78078241
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75138865
66Metabolic pathways_Homo sapiens_hsa011000.72296295
67Lysosome_Homo sapiens_hsa041420.70697951
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70644700
69Type II diabetes mellitus_Homo sapiens_hsa049300.70603073
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70166399
71Retinol metabolism_Homo sapiens_hsa008300.70019112
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69779486
73RNA polymerase_Homo sapiens_hsa030200.69583672
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69324743
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69158686
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67733808
77Morphine addiction_Homo sapiens_hsa050320.67442547
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66372209
79Vitamin digestion and absorption_Homo sapiens_hsa049770.66304510
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.65025177
81Proteasome_Homo sapiens_hsa030500.64559114
82Mineral absorption_Homo sapiens_hsa049780.63833571
83Salivary secretion_Homo sapiens_hsa049700.63463130
84Other glycan degradation_Homo sapiens_hsa005110.61612082
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61078255
86Fatty acid metabolism_Homo sapiens_hsa012120.61059018
87Chemical carcinogenesis_Homo sapiens_hsa052040.60850831
88Arginine biosynthesis_Homo sapiens_hsa002200.60833811
89Circadian entrainment_Homo sapiens_hsa047130.60728727
90Carbon metabolism_Homo sapiens_hsa012000.59939923
91Thyroid hormone synthesis_Homo sapiens_hsa049180.58327811
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54811719
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.54750089
94Phototransduction_Homo sapiens_hsa047440.53849519
95Pancreatic secretion_Homo sapiens_hsa049720.52424243
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52191053
97Phagosome_Homo sapiens_hsa041450.51949461
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51787151
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51762623
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51457358
101Olfactory transduction_Homo sapiens_hsa047400.50419192
102Starch and sucrose metabolism_Homo sapiens_hsa005000.50167187
103Sphingolipid metabolism_Homo sapiens_hsa006000.50025267
104Bile secretion_Homo sapiens_hsa049760.49899406
105Ovarian steroidogenesis_Homo sapiens_hsa049130.49645777
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.48404184
107Fructose and mannose metabolism_Homo sapiens_hsa000510.45841771
108Renin secretion_Homo sapiens_hsa049240.45260231
109Steroid biosynthesis_Homo sapiens_hsa001000.44177918
110RNA degradation_Homo sapiens_hsa030180.43964928
111Fatty acid biosynthesis_Homo sapiens_hsa000610.43667613
112Cholinergic synapse_Homo sapiens_hsa047250.43533875
113Gastric acid secretion_Homo sapiens_hsa049710.43260053
114Purine metabolism_Homo sapiens_hsa002300.42583002
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.41335664
116Prion diseases_Homo sapiens_hsa050200.40001260
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39577808
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39396854
119N-Glycan biosynthesis_Homo sapiens_hsa005100.36502616
120ABC transporters_Homo sapiens_hsa020100.34521891
121Glutathione metabolism_Homo sapiens_hsa004800.32495972
122Glycerolipid metabolism_Homo sapiens_hsa005610.31181012
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31083500
124Glutamatergic synapse_Homo sapiens_hsa047240.30707513
125Arachidonic acid metabolism_Homo sapiens_hsa005900.30633708
126Long-term depression_Homo sapiens_hsa047300.29415497
127Circadian rhythm_Homo sapiens_hsa047100.29247309

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