DNAJB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.72241855
2plasma membrane fusion (GO:0045026)9.64062883
3motile cilium assembly (GO:0044458)9.34009572
4axonemal dynein complex assembly (GO:0070286)9.33245899
5reproduction (GO:0000003)9.23369121
6regulation of cilium movement (GO:0003352)8.72461371
7response to pheromone (GO:0019236)8.46003788
8cilium movement (GO:0003341)7.73910847
9sperm capacitation (GO:0048240)7.45055240
10cilium or flagellum-dependent cell motility (GO:0001539)7.33542698
11organic cation transport (GO:0015695)7.20474689
12single fertilization (GO:0007338)7.16218334
13spermatogenesis (GO:0007283)7.13620212
14male gamete generation (GO:0048232)7.10964267
15synaptonemal complex organization (GO:0070193)7.00162479
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.95552925
17synaptonemal complex assembly (GO:0007130)6.95358344
18rRNA methylation (GO:0031167)6.94963220
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.90252743
20microtubule depolymerization (GO:0007019)6.80251600
21gamete generation (GO:0007276)6.53101911
22male meiosis (GO:0007140)6.52564471
23chromosome condensation (GO:0030261)6.38485420
24phosphatidylethanolamine metabolic process (GO:0046337)6.35761914
25protein targeting to Golgi (GO:0000042)6.27133366
26fertilization (GO:0009566)6.13438716
27piRNA metabolic process (GO:0034587)6.10665023
28establishment of protein localization to Golgi (GO:0072600)6.04841752
29DNA packaging (GO:0006323)6.00718864
30calcium ion-dependent exocytosis (GO:0017156)5.96191186
31cellular ketone body metabolic process (GO:0046950)5.94832959
32spermatid nucleus differentiation (GO:0007289)5.94832800
33retrograde transport, vesicle recycling within Golgi (GO:0000301)5.83312694
34rRNA modification (GO:0000154)5.80392625
35germ cell development (GO:0007281)5.57429717
36glycerol ether metabolic process (GO:0006662)5.54844688
37sexual reproduction (GO:0019953)5.48657121
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.42765698
39ketone body metabolic process (GO:1902224)5.24840021
40regulation of microtubule-based movement (GO:0060632)5.16721661
41multicellular organismal reproductive process (GO:0048609)5.13828045
42ether metabolic process (GO:0018904)5.12901014
43cell recognition (GO:0008037)5.10701391
44single strand break repair (GO:0000012)4.97195818
45ventricular system development (GO:0021591)4.93714713
46microtubule severing (GO:0051013)4.89721122
47centriole replication (GO:0007099)4.78911725
48regulation of Rab GTPase activity (GO:0032313)4.73922589
49positive regulation of Rab GTPase activity (GO:0032851)4.73922589
50seminiferous tubule development (GO:0072520)4.66462540
51chromosome organization involved in meiosis (GO:0070192)4.62584489
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48257984
53protein localization to Golgi apparatus (GO:0034067)4.47458905
54centriole assembly (GO:0098534)4.46370295
55male meiosis I (GO:0007141)4.41637169
56regulation of transcription involved in cell fate commitment (GO:0060850)4.37304175
57chaperone-mediated protein complex assembly (GO:0051131)4.36764096
58left/right pattern formation (GO:0060972)4.25833696
59* regulation of inclusion body assembly (GO:0090083)4.16176052
60multicellular organismal development (GO:0007275)4.14889695
61coenzyme catabolic process (GO:0009109)3.97383335
62DNA methylation involved in gamete generation (GO:0043046)3.95287609
63meiotic nuclear division (GO:0007126)3.92267496
64sequestering of actin monomers (GO:0042989)3.91697995
65* negative regulation of inclusion body assembly (GO:0090084)3.88305575
66response to acidic pH (GO:0010447)3.83353910
67regulation of centriole replication (GO:0046599)3.75449431
68protein K11-linked deubiquitination (GO:0035871)3.66897742
69regulation of phosphoprotein phosphatase activity (GO:0043666)3.54984548
70cellular response to pH (GO:0071467)3.53100093
71peptidyl-threonine dephosphorylation (GO:0035970)3.51272943
72protein polyglutamylation (GO:0018095)3.51258074
73meiosis I (GO:0007127)3.50017345
74negative regulation of Rho protein signal transduction (GO:0035024)3.48902190
75regulation of spindle checkpoint (GO:0090231)3.47795825
76genitalia morphogenesis (GO:0035112)3.47783495
77protein refolding (GO:0042026)3.46942125
78microtubule polymerization or depolymerization (GO:0031109)3.46578553
79musculoskeletal movement (GO:0050881)3.45004682
80multicellular organismal movement (GO:0050879)3.45004682
81polyamine biosynthetic process (GO:0006596)3.33546845
82glycolytic process (GO:0006096)3.33351810
83positive regulation of macrophage activation (GO:0043032)3.33147868
84nucleus organization (GO:0006997)3.29354002
85histone H3-K9 demethylation (GO:0033169)3.27967589
86interferon-gamma secretion (GO:0072643)3.23356791
87chromatin silencing (GO:0006342)3.22386610
88mitotic sister chromatid cohesion (GO:0007064)3.15670102
89cerebral cortex neuron differentiation (GO:0021895)3.13136659
90regulation of interleukin-13 production (GO:0032656)3.13050580
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.11988057
92carnitine transport (GO:0015879)3.11300757
93amino-acid betaine transport (GO:0015838)3.11300757
94homeostasis of number of cells within a tissue (GO:0048873)3.10503722
95cranial nerve morphogenesis (GO:0021602)3.08651176
96RNA localization (GO:0006403)3.07558282
97protein depolymerization (GO:0051261)3.07116288
98meiotic cell cycle (GO:0051321)3.05975615
99RNA destabilization (GO:0050779)3.05586968
100glomerular visceral epithelial cell development (GO:0072015)3.01805306
101nucleoside diphosphate phosphorylation (GO:0006165)3.00676921
102glomerular epithelial cell development (GO:0072310)2.94165899
103regulation of T-helper 2 cell differentiation (GO:0045628)2.92365420
104carnitine transmembrane transport (GO:1902603)2.89744894
105polyol catabolic process (GO:0046174)2.89619611
106microtubule nucleation (GO:0007020)2.89115301
107alditol metabolic process (GO:0019400)2.87115500
108mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86683615
109mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86683615
110regulation of ARF GTPase activity (GO:0032312)2.85795181
111mitochondrion degradation (GO:0000422)2.84246678
112monoubiquitinated protein deubiquitination (GO:0035520)2.82692895
113DNA conformation change (GO:0071103)2.80404247
114regulation of cilium assembly (GO:1902017)2.79254707
115membrane protein intracellular domain proteolysis (GO:0031293)2.76520628
116protein localization to cilium (GO:0061512)2.73968759
117histone exchange (GO:0043486)2.73966725
118GTP biosynthetic process (GO:0006183)2.73671233
119regulation of somitogenesis (GO:0014807)2.73464861
120cell differentiation involved in metanephros development (GO:0072202)2.69013256
121mitotic G1 DNA damage checkpoint (GO:0031571)2.68089790
122cellular biogenic amine biosynthetic process (GO:0042401)2.65440116
123positive regulation of glycolytic process (GO:0045821)2.64933284
124meiotic cell cycle process (GO:1903046)2.62586638
125cilium organization (GO:0044782)2.61792829
126synapsis (GO:0007129)2.56594567
127nucleosome disassembly (GO:0006337)2.56213752
128protein-DNA complex disassembly (GO:0032986)2.56213752
129cellular component assembly involved in morphogenesis (GO:0010927)2.52755684
130microtubule-based movement (GO:0007018)2.51820202
131cilium assembly (GO:0042384)2.51006461
132negative regulation of gene expression, epigenetic (GO:0045814)2.45580902
133UTP biosynthetic process (GO:0006228)2.44886513
134cilium morphogenesis (GO:0060271)2.44602195
135peptidyl-glutamic acid modification (GO:0018200)2.42274515
136sperm motility (GO:0030317)14.9211686
137cell wall macromolecule catabolic process (GO:0016998)13.7986774
138cell wall macromolecule metabolic process (GO:0044036)13.7986774
139acrosome reaction (GO:0007340)13.0651038
140fusion of sperm to egg plasma membrane (GO:0007342)12.6609607
141sperm-egg recognition (GO:0035036)11.7361871
142acrosome assembly (GO:0001675)11.6983922
143binding of sperm to zona pellucida (GO:0007339)10.8047989
144cell-cell recognition (GO:0009988)10.5085002
145multicellular organism reproduction (GO:0032504)10.3042969
146spermatid development (GO:0007286)10.1704481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.62192090
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.22251225
3EZH2_22144423_ChIP-Seq_EOC_Human4.18456148
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.69505185
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46838350
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30657088
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.01874215
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.89637254
9VDR_22108803_ChIP-Seq_LS180_Human2.72056315
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47784272
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44181881
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.41662815
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.32067324
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24368521
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19660787
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09536757
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.08765403
18ZNF274_21170338_ChIP-Seq_K562_Hela2.04214078
19DROSHA_22980978_ChIP-Seq_HELA_Human1.98445576
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95594678
21ERA_21632823_ChIP-Seq_H3396_Human1.95124319
22RAC3_21632823_ChIP-Seq_H3396_Human1.94060020
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.93384752
24FUS_26573619_Chip-Seq_HEK293_Human1.84921536
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84049798
26KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82243533
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.81861167
28ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77007478
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.76397043
30* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.73401153
31STAT1_17558387_ChIP-Seq_HELA_Human1.73116444
32* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69556600
33* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69151204
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.66484110
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65905204
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62158447
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61284936
38* BCL6_27268052_Chip-Seq_Bcells_Human1.59738436
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.59426274
40* SMC4_20622854_ChIP-Seq_HELA_Human1.59131079
41E2F1_20622854_ChIP-Seq_HELA_Human1.58356981
42MYC_19829295_ChIP-Seq_ESCs_Human1.56836409
43TAF2_19829295_ChIP-Seq_ESCs_Human1.55477990
44OCT4_20526341_ChIP-Seq_ESCs_Human1.55140506
45ER_23166858_ChIP-Seq_MCF-7_Human1.54933968
46FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53868241
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52162089
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49344389
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.48923145
50TP63_22573176_ChIP-Seq_HFKS_Human1.47297066
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.46729516
52KDM2B_26808549_Chip-Seq_REH_Human1.45735919
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45241836
54AR_25329375_ChIP-Seq_VCAP_Human1.44960314
55* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44343898
56P53_21459846_ChIP-Seq_SAOS-2_Human1.42719109
57* P68_20966046_ChIP-Seq_HELA_Human1.41824992
58* PHF8_20622854_ChIP-Seq_HELA_Human1.40383188
59* SMAD4_21741376_ChIP-Seq_EPCs_Human1.39406163
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39361473
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39064825
62REST_21632747_ChIP-Seq_MESCs_Mouse1.37833677
63CBP_20019798_ChIP-Seq_JUKART_Human1.37244169
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37244169
65* LXR_22292898_ChIP-Seq_THP-1_Human1.36844488
66HNFA_21074721_ChIP-Seq_CACO-2_Human1.36537473
67LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36245320
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35604507
69CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35378772
70TP53_18474530_ChIP-ChIP_U2OS_Human1.35204398
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33512235
72RBPJ_21746931_ChIP-Seq_IB4_Human1.33258769
73* TAL1_26923725_Chip-Seq_HPCs_Mouse1.32872810
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32505916
75P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.32470122
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.30716417
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.30564505
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30404565
79CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28427875
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28222444
81* P300_27268052_Chip-Seq_Bcells_Human1.26658104
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26455949
83ETV1_20927104_ChIP-Seq_GIST48_Human1.26292856
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25995651
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.25989560
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25573283
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.24642645
88* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23776468
89TBL1_22424771_ChIP-Seq_293T_Human1.22333521
90P300_19829295_ChIP-Seq_ESCs_Human1.21988061
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.21755088
92CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21284947
93SPI1_26923725_Chip-Seq_HPCs_Mouse1.21224413
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19533962
95* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19114285
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18744857
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.18573227
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.17712862
99CEBPB_22108803_ChIP-Seq_LS180_Human1.17369340
100* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17143357
101* SMAD3_21741376_ChIP-Seq_ESCs_Human1.17029949
102* GF1_26923725_Chip-Seq_HPCs_Mouse1.16776705
103RUNX_20019798_ChIP-Seq_JUKART_Human1.16498596
104MYC_27129775_Chip-Seq_CORNEA_Mouse1.15764444
105* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15645824
106JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14471178
107* TET1_21451524_ChIP-Seq_MESCs_Mouse1.13273376
108SMAD4_21741376_ChIP-Seq_HESCs_Human1.13164430
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13131867
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12984282
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12657604
112ERG_20517297_ChIP-Seq_VCAP_Human1.12087641
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12042034
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.11841744
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11462390
116SA1_27219007_Chip-Seq_Bcells_Human1.11248931
117PHF8_20622853_ChIP-Seq_HELA_Human1.10811012
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10483514
119ESET_19884257_ChIP-Seq_ESCs_Mouse1.10438333
120* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10311727
121YY1_22570637_ChIP-Seq_MALME-3M_Human1.10082576
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.09037390
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08696116
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08648584
125AR_21572438_ChIP-Seq_LNCaP_Human1.08486797
126SMRT_27268052_Chip-Seq_Bcells_Human1.08479540
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07963146
128RUNX2_22187159_ChIP-Seq_PCA_Human1.07207738
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.07178669
130SMAD4_21799915_ChIP-Seq_A2780_Human1.06916852
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06037621
132CTCF_20526341_ChIP-Seq_ESCs_Human1.05674100
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05013499
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04574980
135NANOG_19829295_ChIP-Seq_ESCs_Human1.04422104
136SOX2_19829295_ChIP-Seq_ESCs_Human1.04422104
137NFYA_21822215_ChIP-Seq_K562_Human1.02414462
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02019928
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01256701
140SOX11_22085726_ChIP-Seq_ESNs_Mouse1.01146200
141PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01093378
142TP63_19390658_ChIP-ChIP_HaCaT_Human1.00954561
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00178775
144LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99059612
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.98889837
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98720023
147* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98440193
148TAF15_26573619_Chip-Seq_HEK293_Human0.98227916
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.98075678
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.97825270
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.97663513
152SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97631886
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97577779
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.97429485
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94962107
156MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94637705
157FLI1_21867929_ChIP-Seq_CD8_Mouse0.94375038
158NFYB_21822215_ChIP-Seq_K562_Human0.93231537
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92816043
160* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92762879
161* BCOR_27268052_Chip-Seq_Bcells_Human0.92309675
162NANOG_20526341_ChIP-Seq_ESCs_Human0.91880806
163OCT4_18555785_Chip-Seq_ESCs_Mouse0.90121656
164P53_22387025_ChIP-Seq_ESCs_Mouse0.87705445
165* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87178208
166* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87178208
167SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86972134
168OCT1_27270436_Chip-Seq_PROSTATE_Human0.86921986
169CTCF_27219007_Chip-Seq_Bcells_Human0.86462440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.07600497
2MP0001929_abnormal_gametogenesis5.52986301
3MP0008877_abnormal_DNA_methylation3.50579989
4MP0002161_abnormal_fertility/fecundity3.31712387
5MP0005670_abnormal_white_adipose3.30396007
6MP0002210_abnormal_sex_determination3.19817704
7MP0001145_abnormal_male_reproductive2.72113948
8MP0000678_abnormal_parathyroid_gland2.43499177
9MP0000653_abnormal_sex_gland2.33811451
10MP0003718_maternal_effect2.13455970
11MP0002132_abnormal_respiratory_system2.05219601
12MP0005410_abnormal_fertilization16.9818099
13MP0002653_abnormal_ependyma_morphology1.86061422
14MP0005423_abnormal_somatic_nervous1.62705019
15MP0002249_abnormal_larynx_morphology1.58177305
16MP0004233_abnormal_muscle_weight1.49281959
17MP0003646_muscle_fatigue1.44314407
18MP0001485_abnormal_pinna_reflex1.43390409
19MP0005379_endocrine/exocrine_gland_phen1.42028566
20MP0001486_abnormal_startle_reflex1.35197968
21MP0002160_abnormal_reproductive_system1.28012681
22MP0005310_abnormal_salivary_gland1.27260912
23MP0009053_abnormal_anal_canal1.23788878
24MP0004859_abnormal_synaptic_plasticity1.23143793
25MP0002735_abnormal_chemical_nociception1.21309788
26MP0005623_abnormal_meninges_morphology1.15067331
27MP0001765_abnormal_ion_homeostasis1.14142507
28MP0002234_abnormal_pharynx_morphology1.12199126
29MP0002138_abnormal_hepatobiliary_system1.10751732
30MP0004510_myositis1.08628079
31MP0002127_abnormal_cardiovascular_syste1.05274702
32MP0001963_abnormal_hearing_physiology1.05131952
33MP0002282_abnormal_trachea_morphology1.03398501
34MP0005395_other_phenotype1.00478196
35MP0001984_abnormal_olfaction1.00003684
36MP0001905_abnormal_dopamine_level0.93875905
37MP0005248_abnormal_Harderian_gland0.93594198
38MP0000026_abnormal_inner_ear0.93285767
39MP0000955_abnormal_spinal_cord0.82606827
40MP0005451_abnormal_body_composition0.78976944
41MP0000681_abnormal_thyroid_gland0.78109036
42MP0002067_abnormal_sensory_capabilities0.77890711
43MP0004085_abnormal_heartbeat0.76033483
44MP0005647_abnormal_sex_gland0.72394038
45MP0000049_abnormal_middle_ear0.72213781
46MP0003115_abnormal_respiratory_system0.71947200
47MP0002557_abnormal_social/conspecific_i0.68840369
48MP0008058_abnormal_DNA_repair0.68560409
49MP0005083_abnormal_biliary_tract0.68271373
50MP0005636_abnormal_mineral_homeostasis0.68144242
51MP0002733_abnormal_thermal_nociception0.67269836
52MP0009046_muscle_twitch0.66936252
53MP0005666_abnormal_adipose_tissue0.66007660
54MP0001501_abnormal_sleep_pattern0.65667282
55MP0001879_abnormal_lymphatic_vessel0.65501820
56MP0003329_amyloid_beta_deposits0.63958702
57MP0003011_delayed_dark_adaptation0.63736048
58MP0002736_abnormal_nociception_after0.61402389
59MP0002572_abnormal_emotion/affect_behav0.61074277
60MP0009745_abnormal_behavioral_response0.60702030
61MP0005389_reproductive_system_phenotype0.59436910
62MP0002272_abnormal_nervous_system0.57419781
63MP0005167_abnormal_blood-brain_barrier0.56798814
64MP0008995_early_reproductive_senescence0.56122987
65MP0003878_abnormal_ear_physiology0.55592138
66MP0005377_hearing/vestibular/ear_phenot0.55592138
67MP0001764_abnormal_homeostasis0.55145734
68MP0004036_abnormal_muscle_relaxation0.54240017
69MP0001324_abnormal_eye_pigmentation0.50180506
70MP0002269_muscular_atrophy0.49708084
71MP0009697_abnormal_copulation0.49666705
72MP0004484_altered_response_of0.49398448
73MP0000516_abnormal_urinary_system0.49210969
74MP0005367_renal/urinary_system_phenotyp0.49210969
75MP0001440_abnormal_grooming_behavior0.49082038
76MP0001970_abnormal_pain_threshold0.48608155
77MP0000470_abnormal_stomach_morphology0.48365260
78MP0001666_abnormal_nutrient_absorption0.47288136
79MP0000534_abnormal_ureter_morphology0.46558618
80MP0003635_abnormal_synaptic_transmissio0.46536954
81MP0002638_abnormal_pupillary_reflex0.45226891
82MP0001293_anophthalmia0.44836691
83MP0006036_abnormal_mitochondrial_physio0.43233897
84MP0003699_abnormal_female_reproductive0.42003489
85MP0003119_abnormal_digestive_system0.41885567
86MP0002734_abnormal_mechanical_nocicepti0.41549766
87MP0003137_abnormal_impulse_conducting0.41461787
88MP0000358_abnormal_cell_content/0.41424397
89MP0003936_abnormal_reproductive_system0.41114793
90MP0003632_abnormal_nervous_system0.40519723
91MP0003077_abnormal_cell_cycle0.40053308
92MP0001545_abnormal_hematopoietic_system0.39915903
93MP0005397_hematopoietic_system_phenotyp0.39915903
94MP0000230_abnormal_systemic_arterial0.39679698
95MP0005253_abnormal_eye_physiology0.38914667
96MP0009278_abnormal_bone_marrow0.38283239
97MP0009115_abnormal_fat_cell0.37814265
98MP0001270_distended_abdomen0.37659913
99MP0005535_abnormal_body_temperature0.37362714
100MP0000569_abnormal_digit_pigmentation0.37007579
101MP0001968_abnormal_touch/_nociception0.35831490
102MP0000249_abnormal_blood_vessel0.34727776
103MP0002928_abnormal_bile_duct0.34601647
104MP0000604_amyloidosis0.34150430
105MP0002139_abnormal_hepatobiliary_system0.33775741
106MP0002882_abnormal_neuron_morphology0.33729960
107MP0004133_heterotaxia0.33572336
108MP0008004_abnormal_stomach_pH0.33400337
109MP0003942_abnormal_urinary_system0.33024323
110MP0005551_abnormal_eye_electrophysiolog0.32816234
111MP0000003_abnormal_adipose_tissue0.32568202
112MP0003880_abnormal_central_pattern0.32263135
113MP0005391_vision/eye_phenotype0.29436787
114MP0003633_abnormal_nervous_system0.29200388
115MP0004811_abnormal_neuron_physiology0.29198219
116MP0002971_abnormal_brown_adipose0.27139160
117MP0002169_no_abnormal_phenotype0.25620499
118MP0002873_normal_phenotype0.25405131
119MP0003950_abnormal_plasma_membrane0.25002579
120MP0001849_ear_inflammation0.24043280
121MP0003948_abnormal_gas_homeostasis0.24009975
122MP0003631_nervous_system_phenotype0.23716020
123MP0002295_abnormal_pulmonary_circulatio0.22946725
124MP0005375_adipose_tissue_phenotype0.22924012
125MP0004019_abnormal_vitamin_homeostasis0.22830230
126MP0010094_abnormal_chromosome_stability0.22636058
127MP0003861_abnormal_nervous_system0.22423304
128MP0003879_abnormal_hair_cell0.22277931
129MP0001730_embryonic_growth_arrest0.20995559
130MP0004742_abnormal_vestibular_system0.20884317
131MP0002152_abnormal_brain_morphology0.20594680
132MP0004145_abnormal_muscle_electrophysio0.20380056
133MP0003111_abnormal_nucleus_morphology0.20222840
134MP0004270_analgesia0.20133674
135MP0006035_abnormal_mitochondrial_morpho0.19780383
136MP0002796_impaired_skin_barrier0.19727999
137MP0008569_lethality_at_weaning0.17749421
138MP0001119_abnormal_female_reproductive0.17494354
139MP0008875_abnormal_xenobiotic_pharmacok0.17391642
140MP0004043_abnormal_pH_regulation0.16950893
141MP0002909_abnormal_adrenal_gland0.16766775
142MP0002693_abnormal_pancreas_physiology0.16274117
143MP0000462_abnormal_digestive_system0.16249260
144MP0002092_abnormal_eye_morphology0.15631580
145MP0002118_abnormal_lipid_homeostasis0.14982734
146MP0000001_mammalian_phenotype0.14699179
147MP0005319_abnormal_enzyme/_coenzyme0.14588593
148MP0002102_abnormal_ear_morphology0.14305685
149MP0005365_abnormal_bile_salt0.14055259
150MP0003806_abnormal_nucleotide_metabolis0.13826884
151MP0002229_neurodegeneration0.13667523
152MP0003959_abnormal_lean_body0.12895993
153MP0000751_myopathy0.12344662
154MP0001348_abnormal_lacrimal_gland0.11903556
155MP0008961_abnormal_basal_metabolism0.11590397
156MP0000920_abnormal_myelination0.11264284
157MP0010329_abnormal_lipoprotein_level0.10862928
158MP0003787_abnormal_imprinting0.10760651
159MP0002822_catalepsy0.10689502

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31101745
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28664914
3Abnormal respiratory epithelium morphology (HP:0012253)9.28664914
4Severe visual impairment (HP:0001141)8.23630958
5Chronic bronchitis (HP:0004469)7.40243068
6Rhinitis (HP:0012384)7.27642189
7Infertility (HP:0000789)7.25335832
8Abnormal ciliary motility (HP:0012262)7.22723391
9Nasal polyposis (HP:0100582)6.49352058
10Abnormality of the nasal mucosa (HP:0000433)5.34754301
11Male infertility (HP:0003251)5.19266856
12Attenuation of retinal blood vessels (HP:0007843)5.16796312
13Bony spicule pigmentary retinopathy (HP:0007737)5.13229540
14Resting tremor (HP:0002322)5.08052089
15Chronic hepatic failure (HP:0100626)4.73057924
16Hyperkalemia (HP:0002153)4.65853563
17Bronchitis (HP:0012387)4.59331363
18Abnormal rod and cone electroretinograms (HP:0008323)4.37439334
19Bronchiectasis (HP:0002110)4.32505798
20Abnormality of macular pigmentation (HP:0008002)4.23784148
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.16407417
22Nephronophthisis (HP:0000090)3.88515842
23Potter facies (HP:0002009)3.81519139
24Facial shape deformation (HP:0011334)3.81519139
25Abnormal spermatogenesis (HP:0008669)3.79788186
26Hypoplastic ischia (HP:0003175)3.60311358
27Cone-rod dystrophy (HP:0000548)3.60252367
28Postural instability (HP:0002172)3.51178657
29Recurrent otitis media (HP:0000403)3.27632258
30Enlarged epiphyses (HP:0010580)3.27034268
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.23264505
32Abnormality of the ischium (HP:0003174)3.22183744
33Hypoplasia of the thymus (HP:0000778)3.21508204
34Recurrent sinusitis (HP:0011108)3.18642892
35Hypoalphalipoproteinemia (HP:0003233)3.03673658
36Progressive sensorineural hearing impairment (HP:0000408)3.02792731
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92219756
38Abnormality of the renal medulla (HP:0100957)2.89224354
39Unilateral renal agenesis (HP:0000122)2.83838408
40Abnormal gallbladder physiology (HP:0012438)2.72985820
41Cholecystitis (HP:0001082)2.72985820
42Recurrent bronchitis (HP:0002837)2.72056894
43Progressive cerebellar ataxia (HP:0002073)2.68646979
44Impulsivity (HP:0100710)2.67515515
45Tubulointerstitial nephritis (HP:0001970)2.65002323
46Abnormality of the aortic arch (HP:0012303)2.62399983
47Abnormality of potassium homeostasis (HP:0011042)2.62355360
48Renovascular hypertension (HP:0100817)2.55959988
49Generalized aminoaciduria (HP:0002909)2.53699118
50Tubular atrophy (HP:0000092)2.53112293
51Menstrual irregularities (HP:0000858)2.50737168
52Insulin-resistant diabetes mellitus (HP:0000831)2.45102019
53Abnormality of midbrain morphology (HP:0002418)2.44045360
54Molar tooth sign on MRI (HP:0002419)2.44045360
55Dyschromatopsia (HP:0007641)2.36963005
56Amelogenesis imperfecta (HP:0000705)2.36662512
57Tubulointerstitial abnormality (HP:0001969)2.36435957
58Portal hypertension (HP:0001409)2.34773166
59Abnormality of dental color (HP:0011073)2.28367450
60Flattened epiphyses (HP:0003071)2.28189718
61Azoospermia (HP:0000027)2.24690894
62Abnormality of the costochondral junction (HP:0000919)2.21800481
63Choroideremia (HP:0001139)2.19477922
64Medial flaring of the eyebrow (HP:0010747)2.19331177
65Abnormality of the hepatic vasculature (HP:0006707)2.16173690
66Polyuria (HP:0000103)2.14016760
67Decreased central vision (HP:0007663)2.11913759
68Double outlet right ventricle (HP:0001719)2.09732301
69Congenital malformation of the right heart (HP:0011723)2.09732301
70Gonadotropin excess (HP:0000837)2.08574975
71Myokymia (HP:0002411)2.08002097
72Abnormality of the parathyroid morphology (HP:0011766)2.03346933
73Ventricular tachycardia (HP:0004756)2.03008218
74Widely patent fontanelles and sutures (HP:0004492)2.02094912
75Dynein arm defect of respiratory motile cilia (HP:0012255)13.5080621
76Absent/shortened dynein arms (HP:0200106)13.5080621
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8969215
78Epiphyseal dysplasia (HP:0002656)1.99436615
79Tubulointerstitial fibrosis (HP:0005576)1.98872967
80Osteomalacia (HP:0002749)1.96802738
81Spastic tetraparesis (HP:0001285)1.96612209
82Hyponatremia (HP:0002902)1.96267929
83Recurrent pneumonia (HP:0006532)1.95566456
84Absent epiphyses (HP:0010577)1.95107530
85Abnormality of the epiphysis of the femoral head (HP:0010574)1.94037817
86Optic nerve hypoplasia (HP:0000609)1.92629847
87Hyperuricemia (HP:0002149)1.91387690
88Increased purine levels (HP:0004368)1.91387690
89Hemorrhage of the eye (HP:0011885)1.89614164
90Tetany (HP:0001281)1.87406836
91Progressive hearing impairment (HP:0001730)1.85014969
92Neurofibrillary tangles (HP:0002185)1.84848510
93Abnormality of the pubic bones (HP:0003172)1.83123647
94Focal segmental glomerulosclerosis (HP:0000097)1.82607689
95Abnormality of femoral epiphyses (HP:0006499)1.79939269
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.79939269
97Hypophosphatemic rickets (HP:0004912)1.78518405
98Photophobia (HP:0000613)1.76468761
99Abnormality of chloride homeostasis (HP:0011422)1.76420278
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74635148
101Abnormality of the femoral head (HP:0003368)1.73896850
102Recurrent corneal erosions (HP:0000495)1.73485031
103Congenital sensorineural hearing impairment (HP:0008527)1.73302958
104Flat capital femoral epiphysis (HP:0003370)1.72772303
105Polydipsia (HP:0001959)1.71944920
106Abnormal drinking behavior (HP:0030082)1.71944920
107Bile duct proliferation (HP:0001408)1.70264812
108Abnormal biliary tract physiology (HP:0012439)1.70264812
109Stage 5 chronic kidney disease (HP:0003774)1.68242300
110Heterotopia (HP:0002282)1.64601471
111Asymmetric septal hypertrophy (HP:0001670)1.63595900
112Abnormality of renal excretion (HP:0011036)1.62544312
113Exercise-induced myalgia (HP:0003738)1.61071234
114Postaxial foot polydactyly (HP:0001830)1.60491311
115Bundle branch block (HP:0011710)1.54885728
116Congenital hepatic fibrosis (HP:0002612)1.53607891
117Aplasia/Hypoplasia of the lens (HP:0008063)1.49941852
118Cerebral inclusion bodies (HP:0100314)1.49363922
119Myoglobinuria (HP:0002913)1.48777436
120Bell-shaped thorax (HP:0001591)1.48687799
121Abnormality of the renal cortex (HP:0011035)1.47177475
122Easy fatigability (HP:0003388)1.46658275
123Sensory axonal neuropathy (HP:0003390)1.45730800
124Constricted visual fields (HP:0001133)1.44717885
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44623037
126Hypercholesterolemia (HP:0003124)1.41712628
127Short ribs (HP:0000773)1.40808481
128Oculomotor apraxia (HP:0000657)1.40387309
129Abnormal urine output (HP:0012590)1.39064800
130Fatigable weakness (HP:0003473)1.37907634
131Abnormality of the neuromuscular junction (HP:0003398)1.37907634
132Renal dysplasia (HP:0000110)1.37025030
133Abnormality of permanent molar morphology (HP:0011071)1.35192202
134Abnormality of the dental root (HP:0006486)1.35192202
135Taurodontia (HP:0000679)1.35192202
136Abnormality of dentin (HP:0010299)1.33489535
137Rhabdomyolysis (HP:0003201)1.32963641
138Loss of speech (HP:0002371)1.32356530
139Abnormality of the dental pulp (HP:0006479)1.29569684
140Exercise-induced muscle cramps (HP:0003710)1.29016350
141Postaxial hand polydactyly (HP:0001162)1.28773631
142Cystic liver disease (HP:0006706)1.28366981
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.27594181
144Facial cleft (HP:0002006)1.26534472
145Neoplasm of the heart (HP:0100544)1.26294153
146Cerebellar dysplasia (HP:0007033)1.25951595
147Deformed sella turcica (HP:0002681)1.23910180
148Abnormality of molar morphology (HP:0011070)1.23713069
149Abnormality of molar (HP:0011077)1.23713069
150Chronic sinusitis (HP:0011109)1.20098237
151Hemiparesis (HP:0001269)1.19471464
152Truncal obesity (HP:0001956)1.19030248
153Fibular hypoplasia (HP:0003038)1.18151729
154Generalized muscle weakness (HP:0003324)1.16912445
155Transposition of the great arteries (HP:0001669)1.15645623
156Abnormal connection of the cardiac segments (HP:0011545)1.15645623
157Abnormal ventriculo-arterial connection (HP:0011563)1.15645623
158Decreased muscle mass (HP:0003199)1.14916140
159Retinal dysplasia (HP:0007973)1.14800753
160Broad distal phalanx of finger (HP:0009836)1.13744894
161Abnormality of saccadic eye movements (HP:0000570)1.13416185
162Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.12454724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.91420429
2PDK47.91420429
3TESK16.84100711
4PRKD35.25305444
5PDK25.11322089
6ICK4.84378719
7DDR24.69975448
8MAP4K23.52634255
9INSRR3.43134275
10BRD42.89107019
11PLK22.73762190
12PTK2B2.14988845
13WNK42.06839821
14STK391.99696937
15STK381.97104512
16MST1R1.95294450
17DYRK1B1.80837865
18NEK21.48286380
19PIK3CG1.47385193
20PNCK1.45441040
21SIK21.39819368
22CDK121.37511314
23PDK11.35637960
24MAP3K91.28085791
25CDK71.12834149
26KSR20.99365072
27DYRK30.94197741
28RIPK40.93553316
29AKT30.93229688
30PDPK10.92998263
31MAPK150.87308732
32IRAK10.86854291
33LATS20.82565347
34MAP3K110.81887884
35TYRO30.81003395
36CAMK1D0.78705301
37EEF2K0.75123087
38WNK10.74666387
39CCNB10.67482211
40UHMK10.65776683
41LATS10.64862578
42PASK0.63481050
43CDK30.62889502
44CAMK10.61904175
45RPS6KA20.61141104
46MAP2K20.60283524
47PINK10.59463464
48SGK2230.58504762
49SGK4940.58504762
50BMPR1B0.57772528
51TTK0.57385515
52MAP3K20.57211572
53MAP2K60.57142795
54ROCK10.56429048
55TESK20.56185635
56PRKAA20.54460183
57NTRK20.54382215
58IRAK20.53406927
59CHEK20.53160949
60STK30.51226600
61MUSK0.50377936
62MAP3K80.48728430
63LMTK20.46503010
64ZAK0.45219035
65CDK40.44481846
66MAP3K100.43305956
67TLK10.42764831
68PAK10.42273352
69PRKCG0.41589500
70STK38L0.41172490
71MAPK10.40969119
72CAMK1G0.40529508
73FRK0.38716738
74MARK10.36614564
75CAMK40.36041658
76NTRK30.34882445
77MET0.33477098
78MAPKAPK50.32673726
79PAK20.31977647
80ARAF0.31968379
81CHEK10.31149502
82RPS6KA60.30731081
83RPS6KL10.30135124
84RPS6KC10.30135124
85MARK20.29334188
86SGK10.29222831
87TIE10.28967704
88PAK40.25646436
89PRKCZ0.25535644
90CAMKK10.25097677
91MAPK140.21829362
92CDK150.20568187
93MTOR0.20023660
94ATM0.20016264
95MAPK100.19922785
96PRKCQ0.19811994
97BRSK20.19602500
98RPS6KA50.18074795
99CDK180.17673087
100PRKG20.17020752
101CDK11A0.16374151
102ADRBK20.16331173
103PRKAA10.16026997
104AKT10.15375038
105STK100.15275561
106BRAF0.15202845
107MAPK110.14576310
108MINK10.14508710
109BLK0.14354941
110ATR0.14341768
111JAK30.13820528
112NEK60.13040986
113BRSK10.12910260
114CDK140.11900863
115RPS6KB10.11587657
116OXSR10.11460396
117RPS6KA10.10085293
118WEE10.09262083
119MYLK0.08911864
120SGK20.08001547
121CLK10.07769263
122MAP3K10.07558767
123CSNK2A10.07015889
124CSF1R0.06854530
125PRKCD0.06777631
126PLK10.06703338
127GSK3B0.06108545
128CAMK2A0.04913743
129STK110.04753934
130MARK30.04251042
131PIM10.04183030
132PRKACG0.03448085
133PRKG10.03086988
134PRKCA0.02663677
135CDK60.02447047
136MAPK80.02362990
137PLK40.02274025
138PRKCB0.01994459
139PKN10.01368221
140AURKA0.01100580
141CDK10.00278208
142CSNK2A20.00174378
143CDK20.00062109
144SRC-0.0482352
145MAP3K5-0.0442827
146ZAP70-0.0402148
147YES1-0.0394195
148PRKACB-0.0362361
149TRIB3-0.0360570
150PRKACA-0.0297025
151EPHB1-0.0286325
152RPS6KA3-0.0285853
153PAK6-0.0255715
154PDGFRB-0.0214600
155EGFR-0.0149697
156CSNK1D-0.0124537

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.81025778
2Fatty acid biosynthesis_Homo sapiens_hsa000615.07177663
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.49760897
4Olfactory transduction_Homo sapiens_hsa047403.63075303
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.41618082
6Linoleic acid metabolism_Homo sapiens_hsa005913.30563363
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.12348657
8Pyruvate metabolism_Homo sapiens_hsa006203.06853850
9Vitamin B6 metabolism_Homo sapiens_hsa007502.98055818
10Butanoate metabolism_Homo sapiens_hsa006502.87495648
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51414436
12Glucagon signaling pathway_Homo sapiens_hsa049222.45361201
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32179254
14Propanoate metabolism_Homo sapiens_hsa006402.25380043
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.07793859
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06968981
17Basal transcription factors_Homo sapiens_hsa030221.95853445
18Glycerolipid metabolism_Homo sapiens_hsa005611.91631315
19PPAR signaling pathway_Homo sapiens_hsa033201.90911780
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.80859197
21Selenocompound metabolism_Homo sapiens_hsa004501.79964652
22Fat digestion and absorption_Homo sapiens_hsa049751.71999963
23Mineral absorption_Homo sapiens_hsa049781.70058984
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68205393
25Fructose and mannose metabolism_Homo sapiens_hsa000511.63819230
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63012101
27Fatty acid degradation_Homo sapiens_hsa000711.58647368
28Ether lipid metabolism_Homo sapiens_hsa005651.57524575
29Fatty acid metabolism_Homo sapiens_hsa012121.55830381
30Amphetamine addiction_Homo sapiens_hsa050311.47214960
31Type I diabetes mellitus_Homo sapiens_hsa049401.46099755
32Type II diabetes mellitus_Homo sapiens_hsa049301.44383056
33Oocyte meiosis_Homo sapiens_hsa041141.43855947
34Allograft rejection_Homo sapiens_hsa053301.37696118
35Phenylalanine metabolism_Homo sapiens_hsa003601.37627881
36Pentose phosphate pathway_Homo sapiens_hsa000301.34687613
37Autoimmune thyroid disease_Homo sapiens_hsa053201.34421874
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33687484
39Carbon metabolism_Homo sapiens_hsa012001.32734124
40Cardiac muscle contraction_Homo sapiens_hsa042601.31613019
41Graft-versus-host disease_Homo sapiens_hsa053321.28241402
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.26056057
43Phototransduction_Homo sapiens_hsa047441.21858715
44Dorso-ventral axis formation_Homo sapiens_hsa043201.20509554
45Morphine addiction_Homo sapiens_hsa050321.12828985
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12210875
47Arginine biosynthesis_Homo sapiens_hsa002201.11061762
48Glutathione metabolism_Homo sapiens_hsa004801.08166092
49Hedgehog signaling pathway_Homo sapiens_hsa043401.08007060
50Arginine and proline metabolism_Homo sapiens_hsa003301.05960019
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05203187
52Collecting duct acid secretion_Homo sapiens_hsa049661.03942463
53Antigen processing and presentation_Homo sapiens_hsa046121.01972275
54Renin secretion_Homo sapiens_hsa049241.00384178
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00239023
56Arachidonic acid metabolism_Homo sapiens_hsa005900.96921694
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95124453
58Purine metabolism_Homo sapiens_hsa002300.93435237
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.93341978
60Viral myocarditis_Homo sapiens_hsa054160.92810813
61Insulin secretion_Homo sapiens_hsa049110.91225744
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.90544310
63Chemical carcinogenesis_Homo sapiens_hsa052040.90279024
64Bile secretion_Homo sapiens_hsa049760.86215293
65Thyroid hormone synthesis_Homo sapiens_hsa049180.84092914
66Biosynthesis of amino acids_Homo sapiens_hsa012300.81896029
67Nicotine addiction_Homo sapiens_hsa050330.78285472
68Fanconi anemia pathway_Homo sapiens_hsa034600.75812862
69Estrogen signaling pathway_Homo sapiens_hsa049150.75792281
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74297557
71Long-term potentiation_Homo sapiens_hsa047200.71046519
72Nitrogen metabolism_Homo sapiens_hsa009100.70715299
73mRNA surveillance pathway_Homo sapiens_hsa030150.69996358
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69502118
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69309062
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68935045
77Huntingtons disease_Homo sapiens_hsa050160.68451892
78Pancreatic secretion_Homo sapiens_hsa049720.66601885
79Retinol metabolism_Homo sapiens_hsa008300.65098645
80Salivary secretion_Homo sapiens_hsa049700.64408978
81Influenza A_Homo sapiens_hsa051640.64257345
82Renin-angiotensin system_Homo sapiens_hsa046140.59420970
83ABC transporters_Homo sapiens_hsa020100.59104505
84Legionellosis_Homo sapiens_hsa051340.58110966
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57831353
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.57702564
87Protein digestion and absorption_Homo sapiens_hsa049740.57225532
88Tyrosine metabolism_Homo sapiens_hsa003500.57031214
89Sulfur metabolism_Homo sapiens_hsa009200.56894199
90Systemic lupus erythematosus_Homo sapiens_hsa053220.56240693
91GABAergic synapse_Homo sapiens_hsa047270.55056333
92Gap junction_Homo sapiens_hsa045400.53961286
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.53444658
94Gastric acid secretion_Homo sapiens_hsa049710.51492724
95Synaptic vesicle cycle_Homo sapiens_hsa047210.49894484
96Cholinergic synapse_Homo sapiens_hsa047250.49468322
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48619321
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.48162440
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.47550406
100RNA transport_Homo sapiens_hsa030130.47062951
101MAPK signaling pathway_Homo sapiens_hsa040100.46590095
102Endocytosis_Homo sapiens_hsa041440.46487358
103Calcium signaling pathway_Homo sapiens_hsa040200.46406541
104Serotonergic synapse_Homo sapiens_hsa047260.46102931
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43926601
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41367972
107AMPK signaling pathway_Homo sapiens_hsa041520.41002205
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40703618
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39897638
110Oxytocin signaling pathway_Homo sapiens_hsa049210.39413844
111Tight junction_Homo sapiens_hsa045300.38521167
112Metabolic pathways_Homo sapiens_hsa011000.35969608
113Inositol phosphate metabolism_Homo sapiens_hsa005620.34839510
114VEGF signaling pathway_Homo sapiens_hsa043700.33596523
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33117532
116cAMP signaling pathway_Homo sapiens_hsa040240.32011446
117Alcoholism_Homo sapiens_hsa050340.30225368
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29910811
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28007150
120Viral carcinogenesis_Homo sapiens_hsa052030.27576606
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.26230272
122Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25839515
123Pyrimidine metabolism_Homo sapiens_hsa002400.25102092
124Circadian entrainment_Homo sapiens_hsa047130.24898453
125Cocaine addiction_Homo sapiens_hsa050300.24668121
126Acute myeloid leukemia_Homo sapiens_hsa052210.24176559
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21391562
128Taste transduction_Homo sapiens_hsa047420.21163694
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20126026
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.18185450
131Herpes simplex infection_Homo sapiens_hsa051680.17956058
132ECM-receptor interaction_Homo sapiens_hsa045120.15967594
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14283749
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14279689
135HIF-1 signaling pathway_Homo sapiens_hsa040660.11465335
136Basal cell carcinoma_Homo sapiens_hsa052170.10751490
137Wnt signaling pathway_Homo sapiens_hsa043100.09960977
138Salmonella infection_Homo sapiens_hsa051320.08832604
139B cell receptor signaling pathway_Homo sapiens_hsa046620.07759791
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.06273223
141Glutamatergic synapse_Homo sapiens_hsa047240.04031544
142Insulin resistance_Homo sapiens_hsa049310.01791411

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