DNAJB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.77277396
2axonemal dynein complex assembly (GO:0070286)9.70389052
3spermatid development (GO:0007286)9.59893033
4reproduction (GO:0000003)9.56323212
5cilium or flagellum-dependent cell motility (GO:0001539)9.29241031
6motile cilium assembly (GO:0044458)9.28094015
7response to pheromone (GO:0019236)8.96595415
8regulation of cilium movement (GO:0003352)8.54103013
9cilium movement (GO:0003341)7.86254000
10single fertilization (GO:0007338)7.54865636
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.37547121
12male meiosis (GO:0007140)6.96207551
13synaptonemal complex organization (GO:0070193)6.85893083
14sperm capacitation (GO:0048240)6.84755934
15microtubule depolymerization (GO:0007019)6.79180099
16synaptonemal complex assembly (GO:0007130)6.75985488
17piRNA metabolic process (GO:0034587)6.73074018
18negative regulation of inclusion body assembly (GO:0090084)6.70470520
19spermatogenesis (GO:0007283)6.54352551
20protein targeting to Golgi (GO:0000042)6.53008259
21male gamete generation (GO:0048232)6.52016546
22establishment of protein localization to Golgi (GO:0072600)6.46825555
23organic cation transport (GO:0015695)6.38248913
24fertilization (GO:0009566)6.32343655
25rRNA methylation (GO:0031167)6.11120579
26retrograde transport, vesicle recycling within Golgi (GO:0000301)6.01441744
27gamete generation (GO:0007276)5.98889926
28regulation of inclusion body assembly (GO:0090083)5.59822380
29centriole replication (GO:0007099)5.57105998
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.36129960
31cellular ketone body metabolic process (GO:0046950)5.35417658
32cellular process involved in reproduction in multicellular organism (GO:0022412)5.31314866
33germ cell development (GO:0007281)5.30976845
34calcium ion-dependent exocytosis (GO:0017156)5.28494265
35rRNA modification (GO:0000154)5.22432203
36chromosome condensation (GO:0030261)5.12551010
37phosphatidylethanolamine metabolic process (GO:0046337)5.10350800
38glycerol ether metabolic process (GO:0006662)5.08306403
39spermatid nucleus differentiation (GO:0007289)5.06155553
40protein localization to Golgi apparatus (GO:0034067)5.04623840
41ventricular system development (GO:0021591)4.95870773
42cell recognition (GO:0008037)4.92838153
43regulation of microtubule-based movement (GO:0060632)4.92338532
44DNA packaging (GO:0006323)4.92184116
45ketone body metabolic process (GO:1902224)4.81952148
46chromosome organization involved in meiosis (GO:0070192)4.75913947
47multicellular organismal reproductive process (GO:0048609)4.70406991
48ether metabolic process (GO:0018904)4.69294814
49male meiosis I (GO:0007141)4.64931761
50seminiferous tubule development (GO:0072520)4.41201053
51DNA methylation involved in gamete generation (GO:0043046)4.38437258
52RNA destabilization (GO:0050779)4.35668226
53single strand break repair (GO:0000012)4.35085431
54regulation of centriole replication (GO:0046599)4.31797400
55microtubule severing (GO:0051013)4.25925355
56meiotic nuclear division (GO:0007126)4.22772639
57regulation of Rab GTPase activity (GO:0032313)4.13996681
58positive regulation of Rab GTPase activity (GO:0032851)4.13996681
59sexual reproduction (GO:0019953)4.09717119
60chaperone-mediated protein complex assembly (GO:0051131)4.08946630
61monoubiquitinated protein deubiquitination (GO:0035520)3.88959305
62sequestering of actin monomers (GO:0042989)3.83339272
63meiosis I (GO:0007127)3.80903710
64left/right pattern formation (GO:0060972)3.78048953
65multicellular organismal development (GO:0007275)3.75777091
66genitalia morphogenesis (GO:0035112)3.61136901
67negative regulation of Rho protein signal transduction (GO:0035024)3.53383950
68protein K11-linked deubiquitination (GO:0035871)3.53203295
69regulation of transcription involved in cell fate commitment (GO:0060850)3.51913577
70coenzyme catabolic process (GO:0009109)3.47314159
71microtubule polymerization or depolymerization (GO:0031109)3.44550561
72regulation of spindle checkpoint (GO:0090231)3.40923017
73multicellular organismal movement (GO:0050879)3.36350829
74musculoskeletal movement (GO:0050881)3.36350829
75mitotic sister chromatid cohesion (GO:0007064)3.35778816
76microtubule nucleation (GO:0007020)3.31268437
77meiotic cell cycle (GO:0051321)3.29544736
78nucleus organization (GO:0006997)3.25988033
79protein polyglutamylation (GO:0018095)3.21709792
80polyol catabolic process (GO:0046174)3.13717999
81glycolytic process (GO:0006096)3.12078013
82protein refolding (GO:0042026)3.09872545
83nucleoside diphosphate phosphorylation (GO:0006165)3.07181647
84GTP biosynthetic process (GO:0006183)3.03279974
85spinal cord motor neuron differentiation (GO:0021522)3.02662187
86alditol metabolic process (GO:0019400)3.00672864
87carnitine transport (GO:0015879)2.95762764
88amino-acid betaine transport (GO:0015838)2.95762764
89lactate metabolic process (GO:0006089)2.95133673
90regulation of meiosis I (GO:0060631)2.89290703
91detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.87178066
92detection of light stimulus involved in visual perception (GO:0050908)2.86518631
93detection of light stimulus involved in sensory perception (GO:0050962)2.86518631
94synapsis (GO:0007129)2.85886942
95meiotic cell cycle process (GO:1903046)2.85384462
96protein localization to cilium (GO:0061512)2.84707435
97carnitine transmembrane transport (GO:1902603)2.79443971
98intra-Golgi vesicle-mediated transport (GO:0006891)2.77090370
99cilium organization (GO:0044782)2.76467427
100nephron tubule morphogenesis (GO:0072078)2.75425062
101nephron epithelium morphogenesis (GO:0072088)2.75425062
102UTP biosynthetic process (GO:0006228)2.74907185
103interferon-gamma secretion (GO:0072643)2.73213699
104positive regulation of macrophage activation (GO:0043032)2.71826464
105NAD biosynthetic process (GO:0009435)2.71740600
106negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.71511455
107nuclear pore complex assembly (GO:0051292)2.70802374
108glomerular visceral epithelial cell development (GO:0072015)2.67668048
109positive regulation of action potential (GO:0045760)2.67644621
110axoneme assembly (GO:0035082)2.67464062
111cilium assembly (GO:0042384)2.65433076
112photoreceptor cell maintenance (GO:0045494)2.64062959
113histone mRNA catabolic process (GO:0071044)2.63531351
114somite rostral/caudal axis specification (GO:0032525)2.62587172
115centriole assembly (GO:0098534)2.61799724
116positive regulation of guanylate cyclase activity (GO:0031284)2.61781706
117Golgi to endosome transport (GO:0006895)2.60727846
118microtubule-based movement (GO:0007018)2.60679602
119polyamine biosynthetic process (GO:0006596)2.60359317
120cilium morphogenesis (GO:0060271)2.58393448
121cellular component assembly involved in morphogenesis (GO:0010927)2.58228733
122protein localization to chromosome, centromeric region (GO:0071459)2.54724470
123chromatin silencing (GO:0006342)2.54401217
124alanine transport (GO:0032328)2.52831764
125C4-dicarboxylate transport (GO:0015740)2.51976741
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51833415
127UTP metabolic process (GO:0046051)2.51738319
128gene silencing by RNA (GO:0031047)2.51472891
129glomerular epithelial cell development (GO:0072310)2.50225413
130glycerol metabolic process (GO:0006071)2.48036015
131intraciliary transport (GO:0042073)2.45919299
132regulation of cilium assembly (GO:1902017)2.44653044
133fusion of sperm to egg plasma membrane (GO:0007342)13.9968941
134sperm motility (GO:0030317)13.9081175
135cell wall macromolecule metabolic process (GO:0044036)13.1679886
136cell wall macromolecule catabolic process (GO:0016998)13.1679886
137acrosome assembly (GO:0001675)11.7616447
138acrosome reaction (GO:0007340)11.7194912
139sperm-egg recognition (GO:0035036)11.6316444
140multicellular organism reproduction (GO:0032504)11.1249638
141binding of sperm to zona pellucida (GO:0007339)10.6439852
142plasma membrane fusion (GO:0045026)10.6334914
143cell-cell recognition (GO:0009988)10.4816523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.99094733
2EZH2_22144423_ChIP-Seq_EOC_Human4.18532499
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.07656330
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.15799472
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.12149250
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.71974968
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.56502533
8FUS_26573619_Chip-Seq_HEK293_Human2.53145687
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51784303
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39399631
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.33322782
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32782024
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.31233891
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27481002
15ER_23166858_ChIP-Seq_MCF-7_Human2.16601510
16VDR_22108803_ChIP-Seq_LS180_Human2.13023805
17P300_19829295_ChIP-Seq_ESCs_Human2.05982549
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.03459038
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.00104772
20EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99720538
21GBX2_23144817_ChIP-Seq_PC3_Human1.99045317
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.94354138
23ZNF274_21170338_ChIP-Seq_K562_Hela1.94279073
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91186089
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87259099
26AR_25329375_ChIP-Seq_VCAP_Human1.78700236
27STAT1_17558387_ChIP-Seq_HELA_Human1.74987364
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73704667
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72975234
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.71775897
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70913827
32FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69833609
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69197240
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.68698440
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.67807371
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63520548
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.63434134
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59251585
39SMAD4_21799915_ChIP-Seq_A2780_Human1.59246641
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58784803
41GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58539444
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.57631737
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.57528594
44STAT3_23295773_ChIP-Seq_U87_Human1.56186512
45* SMAD4_21741376_ChIP-Seq_EPCs_Human1.53521589
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52050535
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51773800
48MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.51333105
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.50179110
50KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49654152
51ERA_21632823_ChIP-Seq_H3396_Human1.49428704
52KDM2B_26808549_Chip-Seq_REH_Human1.49101370
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.47315329
54NANOG_19829295_ChIP-Seq_ESCs_Human1.46265001
55SOX2_19829295_ChIP-Seq_ESCs_Human1.46265001
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46046602
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45412368
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.44469064
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42501769
60RUNX2_22187159_ChIP-Seq_PCA_Human1.41210311
61DROSHA_22980978_ChIP-Seq_HELA_Human1.41025799
62AUTS2_25519132_ChIP-Seq_293T-REX_Human1.40313360
63MYC_19829295_ChIP-Seq_ESCs_Human1.38345814
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38102031
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.37563488
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36953933
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36019196
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.35652275
69IGF1R_20145208_ChIP-Seq_DFB_Human1.34230470
70LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33374419
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33259157
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.32829525
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32685230
74* NANOG_20526341_ChIP-Seq_ESCs_Human1.31935805
75ETV1_20927104_ChIP-Seq_GIST48_Human1.31586569
76TCF4_23295773_ChIP-Seq_U87_Human1.30738307
77P53_21459846_ChIP-Seq_SAOS-2_Human1.30700999
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.29498416
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29498416
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29004094
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28749665
82CBP_20019798_ChIP-Seq_JUKART_Human1.28749665
83TP53_18474530_ChIP-ChIP_U2OS_Human1.28182031
84* GATA3_21867929_ChIP-Seq_TH1_Mouse1.27776686
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.27333719
86RBPJ_21746931_ChIP-Seq_IB4_Human1.27291614
87TAF2_19829295_ChIP-Seq_ESCs_Human1.27084099
88RAC3_21632823_ChIP-Seq_H3396_Human1.26311964
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25904734
90SMAD3_21741376_ChIP-Seq_ESCs_Human1.24389675
91SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24246517
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24239253
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23369584
94TBL1_22424771_ChIP-Seq_293T_Human1.23290706
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.22344862
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22162194
97HNFA_21074721_ChIP-Seq_CACO-2_Human1.20558679
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.20392950
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19928387
100CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19268271
101AR_21572438_ChIP-Seq_LNCaP_Human1.18889504
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.18376619
103SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17431177
104CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17097816
105VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16743300
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16661353
107TCF4_22108803_ChIP-Seq_LS180_Human1.16487615
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16092167
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.15819117
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15598217
111PHF8_20622853_ChIP-Seq_HELA_Human1.14688175
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.14668260
113GF1_26923725_Chip-Seq_HPCs_Mouse1.14393918
114NCOR_22424771_ChIP-Seq_293T_Human1.13138636
115CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12616308
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12469046
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12416598
118* OCT4_20526341_ChIP-Seq_ESCs_Human1.12202948
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.12185428
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12045785
121ERG_20517297_ChIP-Seq_VCAP_Human1.11215125
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11077201
123REST_21632747_ChIP-Seq_MESCs_Mouse1.10784460
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09922765
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09492537
126SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.08641330
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08408578
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08040729
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08040729
130RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08037662
131SMRT_27268052_Chip-Seq_Bcells_Human1.07728881
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.06949277
133* HOXB7_26014856_ChIP-Seq_BT474_Human1.06593601
134CEBPB_22108803_ChIP-Seq_LS180_Human1.05872323
135ESET_19884257_ChIP-Seq_ESCs_Mouse1.04671722
136RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04371666
137CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02429783
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01847059
139OCT4_18555785_Chip-Seq_ESCs_Mouse1.01626695
140* RARA_24833708_ChIP-Seq_LIVER_Mouse1.00578893
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.99725212
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99702172
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99607377
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99230242
145P53_22387025_ChIP-Seq_ESCs_Mouse0.98966223
146TAF15_26573619_Chip-Seq_HEK293_Human0.98681131
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97917793
148EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97622812
149OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96378068
150EZH2_27294783_Chip-Seq_NPCs_Mouse0.96316992
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.96243687
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95840498
153* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95182093
154P300_18555785_Chip-Seq_ESCs_Mouse0.94850313
155GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94264724
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93905122
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92913069
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92260357
159TET1_21451524_ChIP-Seq_MESCs_Mouse0.91821136
160KLF4_18555785_Chip-Seq_ESCs_Mouse0.91208961
161ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91141834
162SOX9_26525672_Chip-Seq_HEART_Mouse0.90842202
163NFYB_21822215_ChIP-Seq_K562_Human0.89672437
164* FLI1_21867929_ChIP-Seq_CD8_Mouse0.89630328
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89413909
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.89243182
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88047568
168PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87435414
169KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85679001
170MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85448085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.94790759
2MP0001929_abnormal_gametogenesis5.50315604
3MP0008877_abnormal_DNA_methylation4.28386441
4MP0002210_abnormal_sex_determination3.35654130
5MP0002161_abnormal_fertility/fecundity3.25110255
6MP0001145_abnormal_male_reproductive2.82675628
7MP0005670_abnormal_white_adipose2.82155877
8MP0000653_abnormal_sex_gland2.46398188
9MP0002653_abnormal_ependyma_morphology2.42082669
10MP0001485_abnormal_pinna_reflex2.30612708
11MP0003718_maternal_effect2.16478880
12MP0001348_abnormal_lacrimal_gland2.07860963
13MP0005410_abnormal_fertilization16.1963632
14MP0005379_endocrine/exocrine_gland_phen1.99712610
15MP0001486_abnormal_startle_reflex1.88935100
16MP0002735_abnormal_chemical_nociception1.55237496
17MP0002160_abnormal_reproductive_system1.51937116
18MP0005423_abnormal_somatic_nervous1.42365335
19MP0002102_abnormal_ear_morphology1.40657045
20MP0009745_abnormal_behavioral_response1.40311254
21MP0005645_abnormal_hypothalamus_physiol1.37985489
22MP0004742_abnormal_vestibular_system1.36961999
23MP0005310_abnormal_salivary_gland1.35927772
24MP0008058_abnormal_DNA_repair1.30736356
25MP0003787_abnormal_imprinting1.27653833
26MP0006292_abnormal_olfactory_placode1.26702554
27MP0004233_abnormal_muscle_weight1.26658133
28MP0003195_calcinosis1.25245740
29MP0006072_abnormal_retinal_apoptosis1.21916483
30MP0001501_abnormal_sleep_pattern1.21617850
31MP0003880_abnormal_central_pattern1.21497638
32MP0001765_abnormal_ion_homeostasis1.21473275
33MP0002272_abnormal_nervous_system1.16751525
34MP0001963_abnormal_hearing_physiology1.16515812
35MP0002067_abnormal_sensory_capabilities1.14337673
36MP0003646_muscle_fatigue1.14293520
37MP0000678_abnormal_parathyroid_gland1.14146022
38MP0010094_abnormal_chromosome_stability1.11728223
39MP0002733_abnormal_thermal_nociception1.10758360
40MP0009697_abnormal_copulation1.10459941
41MP0000516_abnormal_urinary_system1.08765140
42MP0005367_renal/urinary_system_phenotyp1.08765140
43MP0002557_abnormal_social/conspecific_i1.08439336
44MP0008995_early_reproductive_senescence1.08076371
45MP0002572_abnormal_emotion/affect_behav1.06302399
46MP0000372_irregular_coat_pigmentation1.03387666
47MP0000026_abnormal_inner_ear1.01971241
48MP0005646_abnormal_pituitary_gland1.01293924
49MP0005623_abnormal_meninges_morphology0.99372939
50MP0002229_neurodegeneration0.99360684
51MP0004859_abnormal_synaptic_plasticity0.98749172
52MP0005397_hematopoietic_system_phenotyp0.98723566
53MP0001545_abnormal_hematopoietic_system0.98723566
54MP0002734_abnormal_mechanical_nocicepti0.97615855
55MP0004270_analgesia0.96971190
56MP0001970_abnormal_pain_threshold0.96687219
57MP0002282_abnormal_trachea_morphology0.96668902
58MP0005084_abnormal_gallbladder_morpholo0.95336252
59MP0005395_other_phenotype0.95211247
60MP0003111_abnormal_nucleus_morphology0.94374406
61MP0000427_abnormal_hair_cycle0.93339896
62MP0002138_abnormal_hepatobiliary_system0.92893469
63MP0008057_abnormal_DNA_replication0.90574097
64MP0006276_abnormal_autonomic_nervous0.89435355
65MP0005647_abnormal_sex_gland0.89217819
66MP0002254_reproductive_system_inflammat0.87113026
67MP0008872_abnormal_physiological_respon0.86057822
68MP0003635_abnormal_synaptic_transmissio0.85177862
69MP0001764_abnormal_homeostasis0.83408060
70MP0001529_abnormal_vocalization0.82869627
71MP0005389_reproductive_system_phenotype0.82032391
72MP0001986_abnormal_taste_sensitivity0.81822972
73MP0004085_abnormal_heartbeat0.81200023
74MP0005636_abnormal_mineral_homeostasis0.80421938
75MP0003950_abnormal_plasma_membrane0.79358643
76MP0010386_abnormal_urinary_bladder0.79271310
77MP0003137_abnormal_impulse_conducting0.78986986
78MP0000955_abnormal_spinal_cord0.78598649
79MP0002837_dystrophic_cardiac_calcinosis0.78203756
80MP0000631_abnormal_neuroendocrine_gland0.75881060
81MP0004043_abnormal_pH_regulation0.75372090
82MP0003878_abnormal_ear_physiology0.74900592
83MP0005377_hearing/vestibular/ear_phenot0.74900592
84MP0001984_abnormal_olfaction0.74696137
85MP0005248_abnormal_Harderian_gland0.72867749
86MP0000049_abnormal_middle_ear0.71943182
87MP0001905_abnormal_dopamine_level0.71579088
88MP0009278_abnormal_bone_marrow0.71063865
89MP0002064_seizures0.70538607
90MP0005167_abnormal_blood-brain_barrier0.66805183
91MP0008789_abnormal_olfactory_epithelium0.66479790
92MP0003329_amyloid_beta_deposits0.65479750
93MP0005195_abnormal_posterior_eye0.65386555
94MP0003786_premature_aging0.65326164
95MP0000230_abnormal_systemic_arterial0.64356281
96MP0002249_abnormal_larynx_morphology0.63525806
97MP0003119_abnormal_digestive_system0.63356913
98MP0003011_delayed_dark_adaptation0.61732612
99MP0001324_abnormal_eye_pigmentation0.61598540
100MP0009046_muscle_twitch0.61227311
101MP0004142_abnormal_muscle_tone0.60489650
102MP0004484_altered_response_of0.60122862
103MP0002752_abnormal_somatic_nervous0.59927124
104MP0002928_abnormal_bile_duct0.59198680
105MP0000569_abnormal_digit_pigmentation0.57571168
106MP0000358_abnormal_cell_content/0.55931437
107MP0005666_abnormal_adipose_tissue0.54474615
108MP0008007_abnormal_cellular_replicative0.54257753
109MP0004808_abnormal_hematopoietic_stem0.54113139
110MP0000604_amyloidosis0.53109372
111MP0003077_abnormal_cell_cycle0.52219078
112MP0003699_abnormal_female_reproductive0.50665377
113MP0002736_abnormal_nociception_after0.50216082
114MP0002234_abnormal_pharynx_morphology0.47439613
115MP0010307_abnormal_tumor_latency0.43716881
116MP0003115_abnormal_respiratory_system0.42111475
117MP0002269_muscular_atrophy0.41007997
118MP0001835_abnormal_antigen_presentation0.39338868
119MP0009115_abnormal_fat_cell0.39319134
120MP0001119_abnormal_female_reproductive0.39047601
121MP0005551_abnormal_eye_electrophysiolog0.38837852
122MP0004036_abnormal_muscle_relaxation0.38535561
123MP0000685_abnormal_immune_system0.37199359
124MP0001293_anophthalmia0.36562740
125MP0001727_abnormal_embryo_implantation0.35291326
126MP0002405_respiratory_system_inflammati0.35252958
127MP0005174_abnormal_tail_pigmentation0.33628105
128MP0005253_abnormal_eye_physiology0.32318622
129MP0005319_abnormal_enzyme/_coenzyme0.32278974
130MP0001730_embryonic_growth_arrest0.31579372
131MP0006036_abnormal_mitochondrial_physio0.31520363
132MP0003879_abnormal_hair_cell0.30079400
133MP0000313_abnormal_cell_death0.29940750
134MP0004019_abnormal_vitamin_homeostasis0.28703911
135MP0005391_vision/eye_phenotype0.28591575
136MP0000015_abnormal_ear_pigmentation0.26517523
137MP0005671_abnormal_response_to0.23612265
138MP0006035_abnormal_mitochondrial_morpho0.23552167
139MP0002132_abnormal_respiratory_system0.23326446
140MP0008469_abnormal_protein_level0.23049430
141MP0003693_abnormal_embryo_hatching0.22762904
142MP0005365_abnormal_bile_salt0.22674166
143MP0002139_abnormal_hepatobiliary_system0.22231498
144MP0002971_abnormal_brown_adipose0.21876534
145MP0003436_decreased_susceptibility_to0.21133088
146MP0003631_nervous_system_phenotype0.21102658
147MP0003633_abnormal_nervous_system0.20753920
148MP0005025_abnormal_response_to0.20604357
149MP0009785_altered_susceptibility_to0.20578506
150MP0002398_abnormal_bone_marrow0.20501175
151MP0003252_abnormal_bile_duct0.20419926
152MP0002876_abnormal_thyroid_physiology0.20373913
153MP0002169_no_abnormal_phenotype0.20363265
154MP0002873_normal_phenotype0.20079826
155MP0008961_abnormal_basal_metabolism0.19723925
156MP0002723_abnormal_immune_serum0.18373408
157MP0010329_abnormal_lipoprotein_level0.17852474
158MP0000689_abnormal_spleen_morphology0.17762866
159MP0001968_abnormal_touch/_nociception0.17192740
160MP0001853_heart_inflammation0.16815041
161MP0002118_abnormal_lipid_homeostasis0.16556275
162MP0002092_abnormal_eye_morphology0.16533107
163MP0001849_ear_inflammation0.16485332
164MP0001800_abnormal_humoral_immune0.15815914
165MP0002419_abnormal_innate_immunity0.15583032
166MP0004957_abnormal_blastocyst_morpholog0.15321661
167MP0002148_abnormal_hypersensitivity_rea0.14836836

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.42666601
2Abnormal respiratory motile cilium morphology (HP:0005938)9.42666601
3Abnormal respiratory motile cilium physiology (HP:0012261)9.30572053
4Abnormal ciliary motility (HP:0012262)7.43056710
5Chronic bronchitis (HP:0004469)7.40955813
6Rhinitis (HP:0012384)7.39888572
7Infertility (HP:0000789)6.74545862
8Nasal polyposis (HP:0100582)6.47024884
9Severe visual impairment (HP:0001141)6.23490480
10Abnormality of the nasal mucosa (HP:0000433)5.29194019
11Bronchitis (HP:0012387)4.68919275
12Male infertility (HP:0003251)4.67689455
13Bronchiectasis (HP:0002110)4.39358145
14Bony spicule pigmentary retinopathy (HP:0007737)4.33052950
15Nephronophthisis (HP:0000090)4.04659467
16Abnormal rod and cone electroretinograms (HP:0008323)3.94158445
17Recurrent sinusitis (HP:0011108)3.84520841
18Abnormal spermatogenesis (HP:0008669)3.78483983
19Abnormality of macular pigmentation (HP:0008002)3.69299089
20Recurrent otitis media (HP:0000403)3.46263722
21Pancreatic cysts (HP:0001737)3.17747213
22Hyperkalemia (HP:0002153)3.17506963
23Progressive cerebellar ataxia (HP:0002073)3.12721018
24Abnormality of the renal medulla (HP:0100957)3.03961397
25Hypoplastic ischia (HP:0003175)2.95692086
26Impulsivity (HP:0100710)2.87736573
27Recurrent bronchitis (HP:0002837)2.87561582
28Congenital stationary night blindness (HP:0007642)2.83042290
29Tubulointerstitial nephritis (HP:0001970)2.80776114
30Cone-rod dystrophy (HP:0000548)2.70447334
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.64115908
32Type II lissencephaly (HP:0007260)2.62503238
33Facial shape deformation (HP:0011334)2.61828637
34Potter facies (HP:0002009)2.61828637
35Abnormality of the ischium (HP:0003174)2.56922813
36Polyuria (HP:0000103)2.54137949
37Pendular nystagmus (HP:0012043)2.53136920
38Aplasia/Hypoplasia of the earlobes (HP:0009906)2.49317978
39Gonadotropin excess (HP:0000837)2.48052523
40Resting tremor (HP:0002322)2.47267155
41Medial flaring of the eyebrow (HP:0010747)2.44104592
42Molar tooth sign on MRI (HP:0002419)2.43881057
43Abnormality of midbrain morphology (HP:0002418)2.43881057
44Optic nerve hypoplasia (HP:0000609)2.37876788
45Enlarged epiphyses (HP:0010580)2.34886270
46Amelogenesis imperfecta (HP:0000705)2.34671778
47Abnormality of dental color (HP:0011073)2.33276936
48Azoospermia (HP:0000027)2.31048908
49Tubulointerstitial abnormality (HP:0001969)2.30927867
50Tubular atrophy (HP:0000092)2.27322500
51Dyschromatopsia (HP:0007641)2.19376449
52Hyperventilation (HP:0002883)2.17742380
53Hypoplasia of the thymus (HP:0000778)2.12981620
54Abnormality of potassium homeostasis (HP:0011042)2.09445487
55Congenital sensorineural hearing impairment (HP:0008527)2.08899779
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08659441
57Intestinal atresia (HP:0011100)2.06802226
58Generalized aminoaciduria (HP:0002909)2.06665323
59Sclerocornea (HP:0000647)2.04747014
60Abnormality of the parathyroid morphology (HP:0011766)2.01516976
61Dynein arm defect of respiratory motile cilia (HP:0012255)13.7454905
62Absent/shortened dynein arms (HP:0200106)13.7454905
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0768270
64Keratoconus (HP:0000563)1.99084143
65Increased corneal curvature (HP:0100692)1.99084143
66Gaze-evoked nystagmus (HP:0000640)1.98773052
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95816682
68Cholecystitis (HP:0001082)1.95605697
69Abnormal gallbladder physiology (HP:0012438)1.95605697
70Renal Fanconi syndrome (HP:0001994)1.93697123
71Glycosuria (HP:0003076)1.91172554
72Abnormality of urine glucose concentration (HP:0011016)1.91172554
73Photophobia (HP:0000613)1.90929530
74Tetany (HP:0001281)1.90568884
75Decreased central vision (HP:0007663)1.88028575
76Portal hypertension (HP:0001409)1.85643244
77Atonic seizures (HP:0010819)1.85346981
78Volvulus (HP:0002580)1.85229782
79Postural instability (HP:0002172)1.84416353
80Abnormality of the pubic bones (HP:0003172)1.84109870
81Anencephaly (HP:0002323)1.81718379
82Choroideremia (HP:0001139)1.81592963
83Occipital encephalocele (HP:0002085)1.81075186
84Abnormality of the aortic arch (HP:0012303)1.78215994
85Tubulointerstitial fibrosis (HP:0005576)1.77959341
86Postaxial foot polydactyly (HP:0001830)1.77929388
87Abnormality of the renal cortex (HP:0011035)1.77331079
88Spastic tetraparesis (HP:0001285)1.76847315
89Unilateral renal agenesis (HP:0000122)1.76522246
90Type 2 muscle fiber atrophy (HP:0003554)1.73990880
91Abnormality of the hepatic vasculature (HP:0006707)1.73411768
92Hypoalbuminemia (HP:0003073)1.72680433
93Abnormal albumin level (HP:0012116)1.72680433
94Intellectual disability, moderate (HP:0002342)1.72478562
95Abolished electroretinogram (ERG) (HP:0000550)1.72004124
96Genital tract atresia (HP:0001827)1.71588529
97Congenital hepatic fibrosis (HP:0002612)1.71493413
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67248391
99Abnormality of the lower motor neuron (HP:0002366)1.62954300
100Stage 5 chronic kidney disease (HP:0003774)1.62754233
101Heterotopia (HP:0002282)1.56929421
102Chronic sinusitis (HP:0011109)1.54037194
103Decreased electroretinogram (ERG) amplitude (HP:0000654)1.53481492
104Short ribs (HP:0000773)1.53156441
105Oculomotor apraxia (HP:0000657)1.49433103
106Asymmetric septal hypertrophy (HP:0001670)1.48681527
107Constricted visual fields (HP:0001133)1.48391097
108Abnormal drinking behavior (HP:0030082)1.47638402
109Polydipsia (HP:0001959)1.47638402
110Fibular hypoplasia (HP:0003038)1.46851095
111Bile duct proliferation (HP:0001408)1.46566613
112Abnormal biliary tract physiology (HP:0012439)1.46566613
113Pancreatic fibrosis (HP:0100732)1.45706032
114Abnormality of renal excretion (HP:0011036)1.44472201
115Hemorrhage of the eye (HP:0011885)1.43171609
116Deformed sella turcica (HP:0002681)1.42922868
117Abnormality of permanent molar morphology (HP:0011071)1.40352263
118Abnormality of the dental root (HP:0006486)1.40352263
119Taurodontia (HP:0000679)1.40352263
120Abnormality of the dental pulp (HP:0006479)1.40130357
121Bell-shaped thorax (HP:0001591)1.39979314
122Aplasia/Hypoplasia of the lens (HP:0008063)1.39599651
123Congenital primary aphakia (HP:0007707)1.39418438
124Vascular calcification (HP:0004934)1.39410685
125Abnormality of dentin (HP:0010299)1.38855129
126Gait imbalance (HP:0002141)1.37075411
127Facial cleft (HP:0002006)1.33443274
128J-shaped sella turcica (HP:0002680)1.33336852
129Postaxial hand polydactyly (HP:0001162)1.33318737
130Absent epiphyses (HP:0010577)1.30476883
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30476883
132Bundle branch block (HP:0011710)1.29609696
133Cystic liver disease (HP:0006706)1.29098475
134Abnormality of molar morphology (HP:0011070)1.28087754
135Abnormality of molar (HP:0011077)1.28087754
136Absent frontal sinuses (HP:0002688)1.26484642
137Easy fatigability (HP:0003388)1.25029651
138Cardiovascular calcification (HP:0011915)1.22196444
139Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.21336792
140Congenital malformation of the right heart (HP:0011723)1.18772887
141Double outlet right ventricle (HP:0001719)1.18772887
142Nephropathy (HP:0000112)1.18397038
143Truncal obesity (HP:0001956)1.18199527
144Attenuation of retinal blood vessels (HP:0007843)1.17766768
145Chronic hepatic failure (HP:0100626)1.16886609
146Nephrogenic diabetes insipidus (HP:0009806)1.16198365
147Cerebellar dysplasia (HP:0007033)1.16195694
148Amyotrophic lateral sclerosis (HP:0007354)1.16121287
149Abnormality of saccadic eye movements (HP:0000570)1.16038577
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.15580094
151True hermaphroditism (HP:0010459)1.15376890
152Renal dysplasia (HP:0000110)1.14401307
153Abnormality of the neuromuscular junction (HP:0003398)1.11366793
154Fatigable weakness (HP:0003473)1.11366793
155Abnormal urine output (HP:0012590)1.11195133
156Short thorax (HP:0010306)1.10122064
157Impaired proprioception (HP:0010831)1.09814595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.72236442
2PDK48.72236442
3TESK15.67043556
4PDK25.63558519
5PRKD34.55631561
6FRK4.20502445
7MAP4K24.04827237
8ICK3.95560867
9INSRR3.72621006
10PLK23.29564813
11BRD42.90801390
12DDR22.23606551
13WNK32.19899557
14BMPR1B1.89470114
15ADRBK21.86149375
16PTK2B1.84495424
17WNK41.80802561
18NEK21.74367220
19PIK3CG1.63788209
20PNCK1.60680637
21STK391.60116947
22MARK11.54349503
23ZAK1.53827002
24CASK1.50476639
25STK381.40010863
26SIK21.39007528
27DYRK1B1.38526676
28NUAK11.36989956
29TNIK1.31621587
30AKT31.29749762
31GRK11.26307627
32MAPK131.19815857
33PDK11.17943731
34MAP3K41.15077217
35OXSR11.11142905
36ACVR1B1.10345848
37TESK20.97734907
38NTRK30.96245123
39TRIM280.82853471
40MKNK20.82810236
41DYRK30.81611603
42TTK0.79730007
43PRKCE0.78916827
44PASK0.78525690
45MAP2K70.74507799
46CCNB10.73751760
47CHEK20.72123885
48CDK70.71069110
49WNK10.69568838
50ERBB30.67820616
51PRKG10.66866553
52RIPK40.64461537
53VRK10.62834919
54TIE10.62429705
55PDPK10.60500331
56PAK30.60047937
57BLK0.60040224
58IRAK10.59426782
59STK30.59293141
60FGFR20.57707752
61MAP2K60.57495007
62EEF2K0.56336566
63BUB10.56014839
64MAPK150.51277365
65PLK40.50288506
66TYRO30.49605140
67DYRK20.48621156
68PKN10.47368856
69PRKAA20.47149119
70CAMK10.46709450
71NEK60.46159139
72CHEK10.46031286
73WEE10.45291927
74TLK10.45173744
75CSNK1G10.44693288
76LATS10.44606304
77ATR0.43578858
78LMTK20.42976928
79PINK10.42952283
80MAP3K90.42783218
81ROCK10.42234661
82CDK30.41346985
83CSNK1G20.40225202
84PAK10.39854530
85MST1R0.39586490
86ADRBK10.38119422
87PRKCG0.36376503
88CAMK1G0.36339089
89FER0.36170485
90CLK10.35489789
91MARK20.35469303
92CAMK1D0.35358434
93CSNK1G30.35087343
94PLK30.34644193
95ATM0.33967105
96SGK4940.33522247
97SGK2230.33522247
98CDC70.33056471
99CAMK2A0.32721425
100DAPK20.32712381
101CDK60.32380195
102PLK10.32130686
103PRKACA0.31620629
104GRK70.31616875
105MAP3K100.31361449
106UHMK10.31184054
107SGK20.30175434
108PHKG10.29302394
109PHKG20.29302394
110MINK10.28178290
111MAPK10.28112587
112CSNK1A1L0.27992908
113NTRK20.27580259
114MUSK0.27386442
115BRSK20.27135944
116SGK10.26620304
117CSNK1A10.25319751
118PAK40.25162633
119PAK20.23432461
120CDK120.23377824
121RPS6KB10.22024456
122STK100.20500138
123IRAK20.20321155
124STK38L0.20318349
125MAP4K10.19015898
126SRPK10.18993989
127MTOR0.18738815
128NEK90.18045465
129BRSK10.17358560
130ZAP700.17317299
131PIM10.16780835
132PRKCQ0.16334827
133CSNK2A10.16095709
134PRKAA10.15747918
135CDK40.15475230
136CDK150.12541780
137CAMKK10.12482489
138MAPKAPK50.11864803
139MARK30.11422602
140PRKCZ0.10742525
141TAOK30.10061426
142CDK180.09665481
143CDK11A0.08780674
144CSNK2A20.08395985
145TAOK10.08124929
146CDK20.08045191
147CSF1R0.07467467
148CSNK1D0.05814764
149CDK10.05602225
150ERN10.05595781
151EIF2AK30.05534527
152BRAF0.05446614
153GSK3B0.05391887
154PRKCD0.04238257
155BTK0.04094893
156MAPK80.03563601
157MAP3K80.03518933
158PRKCB0.02389146
159TXK0.02183696
160PRKACB0.02057868
161PRKG20.01983024
162RPS6KA10.01836336
163PRKCA0.01418005
164EIF2AK10.01080782
165TEC0.00978250
166CDK140.00674504

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.05105533
2Vitamin B6 metabolism_Homo sapiens_hsa007504.43109122
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.42723563
4Fatty acid biosynthesis_Homo sapiens_hsa000614.09344171
5Pyruvate metabolism_Homo sapiens_hsa006203.48986689
6Olfactory transduction_Homo sapiens_hsa047403.35105087
7Butanoate metabolism_Homo sapiens_hsa006503.28502802
8Phototransduction_Homo sapiens_hsa047442.75425917
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73188334
10Linoleic acid metabolism_Homo sapiens_hsa005912.65864873
11Propanoate metabolism_Homo sapiens_hsa006402.65182782
12Basal transcription factors_Homo sapiens_hsa030222.55087816
13Glucagon signaling pathway_Homo sapiens_hsa049222.44215388
14Selenocompound metabolism_Homo sapiens_hsa004502.32936139
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.31908602
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30594325
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.27563292
18Taste transduction_Homo sapiens_hsa047422.18240358
19Carbohydrate digestion and absorption_Homo sapiens_hsa049732.14932153
20Nicotine addiction_Homo sapiens_hsa050332.10756452
21Glycosaminoglycan degradation_Homo sapiens_hsa005312.07584526
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.04561972
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.94345830
24Pentose phosphate pathway_Homo sapiens_hsa000301.91992109
25Glycerolipid metabolism_Homo sapiens_hsa005611.90592164
26PPAR signaling pathway_Homo sapiens_hsa033201.78729997
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69553788
28Fanconi anemia pathway_Homo sapiens_hsa034601.69493275
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.65096750
30Oocyte meiosis_Homo sapiens_hsa041141.64924499
31Fructose and mannose metabolism_Homo sapiens_hsa000511.63679459
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.62035416
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.60640065
34Nitrogen metabolism_Homo sapiens_hsa009101.60636059
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59668643
36Mineral absorption_Homo sapiens_hsa049781.55242700
37Carbon metabolism_Homo sapiens_hsa012001.49964182
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49232106
39Antigen processing and presentation_Homo sapiens_hsa046121.48830312
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42810875
41Type I diabetes mellitus_Homo sapiens_hsa049401.42385050
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41991421
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.41608278
44Purine metabolism_Homo sapiens_hsa002301.40938839
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36303266
46RNA transport_Homo sapiens_hsa030131.29801207
47Morphine addiction_Homo sapiens_hsa050321.28149571
48Fat digestion and absorption_Homo sapiens_hsa049751.27605246
49Amphetamine addiction_Homo sapiens_hsa050311.27563194
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23550214
51Fatty acid degradation_Homo sapiens_hsa000711.23280655
52Fatty acid metabolism_Homo sapiens_hsa012121.18821240
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14916051
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12802588
55mRNA surveillance pathway_Homo sapiens_hsa030151.10401243
56Biosynthesis of amino acids_Homo sapiens_hsa012301.09085992
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08753982
58Ether lipid metabolism_Homo sapiens_hsa005651.04583270
59RNA polymerase_Homo sapiens_hsa030201.02373709
60Allograft rejection_Homo sapiens_hsa053301.01642366
61Glutathione metabolism_Homo sapiens_hsa004800.98658820
62Glutamatergic synapse_Homo sapiens_hsa047240.97829875
63Graft-versus-host disease_Homo sapiens_hsa053320.97125636
64Autoimmune thyroid disease_Homo sapiens_hsa053200.96672620
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.94189379
66GABAergic synapse_Homo sapiens_hsa047270.91729898
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89943668
68Peroxisome_Homo sapiens_hsa041460.89144611
69Tryptophan metabolism_Homo sapiens_hsa003800.88644681
70Dorso-ventral axis formation_Homo sapiens_hsa043200.86886705
71Pyrimidine metabolism_Homo sapiens_hsa002400.85316448
72Type II diabetes mellitus_Homo sapiens_hsa049300.85307299
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83369044
74Legionellosis_Homo sapiens_hsa051340.82407034
75DNA replication_Homo sapiens_hsa030300.81549795
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81145770
77Renin secretion_Homo sapiens_hsa049240.81076641
78Cardiac muscle contraction_Homo sapiens_hsa042600.78605367
79Caffeine metabolism_Homo sapiens_hsa002320.78021539
80Huntingtons disease_Homo sapiens_hsa050160.76787311
81Renin-angiotensin system_Homo sapiens_hsa046140.74945265
82Arginine and proline metabolism_Homo sapiens_hsa003300.74852340
83Arachidonic acid metabolism_Homo sapiens_hsa005900.74534772
84Serotonergic synapse_Homo sapiens_hsa047260.73740435
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71027893
86RNA degradation_Homo sapiens_hsa030180.70959005
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69741913
88Collecting duct acid secretion_Homo sapiens_hsa049660.67589069
89Chemical carcinogenesis_Homo sapiens_hsa052040.66742838
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65312994
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65125436
92Oxidative phosphorylation_Homo sapiens_hsa001900.65116275
93Bile secretion_Homo sapiens_hsa049760.62469665
94Thyroid hormone synthesis_Homo sapiens_hsa049180.61430048
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.61041816
96Staphylococcus aureus infection_Homo sapiens_hsa051500.58506914
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55241759
98Systemic lupus erythematosus_Homo sapiens_hsa053220.53949924
99Circadian rhythm_Homo sapiens_hsa047100.53722148
100One carbon pool by folate_Homo sapiens_hsa006700.53091539
101Inositol phosphate metabolism_Homo sapiens_hsa005620.50744580
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49772871
103Base excision repair_Homo sapiens_hsa034100.49593031
104ABC transporters_Homo sapiens_hsa020100.49260584
105Hedgehog signaling pathway_Homo sapiens_hsa043400.49190496
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.49122220
107Insulin secretion_Homo sapiens_hsa049110.48720081
108Calcium signaling pathway_Homo sapiens_hsa040200.47753978
109Cell cycle_Homo sapiens_hsa041100.46491722
110Metabolic pathways_Homo sapiens_hsa011000.46044929
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45049218
112Long-term potentiation_Homo sapiens_hsa047200.44280476
113Regulation of autophagy_Homo sapiens_hsa041400.43718486
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.43004437
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42578848
116N-Glycan biosynthesis_Homo sapiens_hsa005100.41596063
117Pancreatic secretion_Homo sapiens_hsa049720.41372027
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41060421
119Estrogen signaling pathway_Homo sapiens_hsa049150.40488838
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38971759
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38492168
122Homologous recombination_Homo sapiens_hsa034400.37624286
123Protein digestion and absorption_Homo sapiens_hsa049740.36908932
124Cholinergic synapse_Homo sapiens_hsa047250.34913765
125Endocytosis_Homo sapiens_hsa041440.34891170
126Proteasome_Homo sapiens_hsa030500.34600828
127B cell receptor signaling pathway_Homo sapiens_hsa046620.34507546
128Salivary secretion_Homo sapiens_hsa049700.33585611
129Vitamin digestion and absorption_Homo sapiens_hsa049770.33057680
130Phenylalanine metabolism_Homo sapiens_hsa003600.32707225
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31314786
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30903880
133Parkinsons disease_Homo sapiens_hsa050120.30349191
134Dopaminergic synapse_Homo sapiens_hsa047280.30044703
135Tyrosine metabolism_Homo sapiens_hsa003500.29914253
136Cocaine addiction_Homo sapiens_hsa050300.29426319
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29159704
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28676769
139Retinol metabolism_Homo sapiens_hsa008300.28069184
140Spliceosome_Homo sapiens_hsa030400.25232722
141Gastric acid secretion_Homo sapiens_hsa049710.22987210
142Epstein-Barr virus infection_Homo sapiens_hsa051690.22119640
143Sulfur metabolism_Homo sapiens_hsa009200.21503991
144AMPK signaling pathway_Homo sapiens_hsa041520.19978691
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.18106624
146Non-homologous end-joining_Homo sapiens_hsa034500.17563587
147Synaptic vesicle cycle_Homo sapiens_hsa047210.16953212
148Measles_Homo sapiens_hsa051620.14250816
149Circadian entrainment_Homo sapiens_hsa047130.13183754
150cAMP signaling pathway_Homo sapiens_hsa040240.12393998

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