DNAJB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymphangiogenesis (GO:0001946)4.29738999
2neural crest cell development (GO:0014032)4.00592536
3mesenchymal cell development (GO:0014031)3.84566759
4response to gravity (GO:0009629)3.55049410
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.52906633
6actin-myosin filament sliding (GO:0033275)3.51195782
7muscle filament sliding (GO:0030049)3.51195782
8blood vessel maturation (GO:0001955)3.50831872
9endocardial cushion morphogenesis (GO:0003203)3.33990386
10muscle cell cellular homeostasis (GO:0046716)3.33602420
11stem cell development (GO:0048864)3.30528897
12vascular smooth muscle contraction (GO:0014829)3.28239831
13Notch signaling involved in heart development (GO:0061314)3.22459616
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.21366826
15kidney mesenchyme development (GO:0072074)3.20214906
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.12835072
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.10088560
18wound healing, spreading of epidermal cells (GO:0035313)3.09810231
19regulation of secondary heart field cardioblast proliferation (GO:0003266)3.09652990
20regulation of cardioblast proliferation (GO:0003264)3.09652990
21retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05190024
22protein targeting to Golgi (GO:0000042)3.03754031
23negative regulation of inclusion body assembly (GO:0090084)3.03221085
24cardiac epithelial to mesenchymal transition (GO:0060317)3.00750591
25epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.99813907
26collagen fibril organization (GO:0030199)2.99656783
27muscle cell fate commitment (GO:0042693)2.97260654
28metanephric mesenchyme development (GO:0072075)2.94812827
29somite development (GO:0061053)2.94622693
30notochord development (GO:0030903)2.90218033
31relaxation of cardiac muscle (GO:0055119)2.85584323
32establishment of protein localization to Golgi (GO:0072600)2.85117554
33negative regulation of nitric-oxide synthase activity (GO:0051001)2.83778077
34protein refolding (GO:0042026)2.83603598
35negative regulation of chondrocyte differentiation (GO:0032331)2.82396453
36cell migration involved in heart development (GO:0060973)2.80232453
37mesenchyme morphogenesis (GO:0072132)2.79595349
38ventricular septum morphogenesis (GO:0060412)2.77831546
39negative regulation of protein localization to cell surface (GO:2000009)2.76721918
40outflow tract morphogenesis (GO:0003151)2.76176665
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.75186903
42regulation of cell communication by electrical coupling (GO:0010649)2.73646973
43response to muscle activity (GO:0014850)2.73428175
44negative regulation of axon guidance (GO:1902668)2.73378234
45regulation of relaxation of muscle (GO:1901077)2.73250031
46negative regulation of axon extension involved in axon guidance (GO:0048843)2.71588089
47retrograde transport, vesicle recycling within Golgi (GO:0000301)2.71536511
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.71460466
49positive regulation of protein autophosphorylation (GO:0031954)2.71110404
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69055164
51regulation of skeletal muscle contraction (GO:0014819)2.68072906
52dermatan sulfate biosynthetic process (GO:0030208)2.67231087
53detection of calcium ion (GO:0005513)2.67006811
54chondrocyte proliferation (GO:0035988)2.65971269
55sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65414214
56neuron fate determination (GO:0048664)2.64153219
57regulation of integrin-mediated signaling pathway (GO:2001044)2.63007471
58cardiac muscle cell development (GO:0055013)2.62783732
59negative regulation of complement activation (GO:0045916)2.60682950
60cell proliferation involved in metanephros development (GO:0072203)2.60615543
61ventricular septum development (GO:0003281)2.60414496
62artery development (GO:0060840)2.59561688
63heart contraction (GO:0060047)2.58291609
64heart process (GO:0003015)2.58291609
65smooth muscle tissue development (GO:0048745)2.56219086
66positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56110044
67negative regulation of oligodendrocyte differentiation (GO:0048715)2.56037546
68relaxation of smooth muscle (GO:0044557)2.55039521
69cardiac cell development (GO:0055006)2.52612717
70ventricular cardiac muscle cell development (GO:0055015)2.51521881
71regulation of inclusion body assembly (GO:0090083)2.50508394
72tonic smooth muscle contraction (GO:0014820)2.49527127
73response to inactivity (GO:0014854)2.48253367
74synaptic vesicle exocytosis (GO:0016079)2.48090541
75glutamate secretion (GO:0014047)2.47893722
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47704000
77cell migration involved in sprouting angiogenesis (GO:0002042)2.47584548
78membrane assembly (GO:0071709)2.45970509
79anterior/posterior axis specification, embryo (GO:0008595)2.45693143
80muscle tissue morphogenesis (GO:0060415)2.44828624
81positive regulation of muscle hypertrophy (GO:0014742)2.44755628
82positive regulation of cardiac muscle hypertrophy (GO:0010613)2.44755628
83regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.43989853
84regulation of heart morphogenesis (GO:2000826)2.43959771
85heart valve morphogenesis (GO:0003179)2.43436139
86artery smooth muscle contraction (GO:0014824)2.42789713
87positive regulation of vesicle fusion (GO:0031340)2.42325328
88positive regulation of vascular permeability (GO:0043117)2.41080182
89relaxation of muscle (GO:0090075)2.40774064
90regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40562899
91sprouting angiogenesis (GO:0002040)2.40213107
92vocalization behavior (GO:0071625)2.39161312
93neuronal stem cell maintenance (GO:0097150)2.39159810
94cardiac myofibril assembly (GO:0055003)2.39082635
95regulation of transforming growth factor beta2 production (GO:0032909)2.36280073
96positive regulation of astrocyte differentiation (GO:0048711)2.36015250
97regulation of female gonad development (GO:2000194)2.35918749
98limb bud formation (GO:0060174)2.34719440
99positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.34573118
100negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33853732
101regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.33366038
102cell proliferation involved in kidney development (GO:0072111)2.32279903
103regulation of short-term neuronal synaptic plasticity (GO:0048172)2.31133703
104negative regulation of cartilage development (GO:0061037)2.31118847
105positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.30132367
106regulation of membrane repolarization (GO:0060306)2.29974753
107regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.29889395
108cardiac septum development (GO:0003279)2.29420438
109positive regulation of cartilage development (GO:0061036)2.29204094
110actin filament-based movement (GO:0030048)2.29063269
111regulation of sarcomere organization (GO:0060297)2.28331315
112sulfation (GO:0051923)2.27124220
113embryonic heart tube development (GO:0035050)2.26145909
114dermatan sulfate metabolic process (GO:0030205)2.26008746
115regulation of axon guidance (GO:1902667)2.25475096
116negative regulation of protein activation cascade (GO:2000258)2.25175624
117regulation of cardiac muscle cell differentiation (GO:2000725)2.24712795
118atrioventricular valve morphogenesis (GO:0003181)2.24525540
119regulation of cardiac muscle contraction (GO:0055117)2.23768966
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.23352814
121regulation of acyl-CoA biosynthetic process (GO:0050812)2.22170925
122startle response (GO:0001964)2.20473851
123regulation of calcium ion transmembrane transporter activity (GO:1901019)2.19751103
124regulation of calcium ion transmembrane transport (GO:1903169)2.19751103
125positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19617737
126neuronal action potential propagation (GO:0019227)2.19531767
127cellular potassium ion homeostasis (GO:0030007)2.19013967
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.17968680
129plasma membrane repair (GO:0001778)2.17532783
130striatum development (GO:0021756)2.17461302
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.16279738
132neuron remodeling (GO:0016322)2.15682474
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.13985307
134neurotransmitter-gated ion channel clustering (GO:0072578)2.13785052
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.13774047
136negative regulation of hormone metabolic process (GO:0032351)2.13414254
137negative regulation of hormone biosynthetic process (GO:0032353)2.13414254
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.12744886
139myofibril assembly (GO:0030239)2.10704062
140regulation of synaptic transmission, glutamatergic (GO:0051966)2.10702429
141positive regulation of potassium ion transport (GO:0043268)2.10117435
142regulation of sulfur metabolic process (GO:0042762)2.09004380
143sequestering of extracellular ligand from receptor (GO:0035581)2.07683655
144regulation of synaptic vesicle exocytosis (GO:2000300)2.07118616
145regulation of cardiac muscle hypertrophy (GO:0010611)2.06257986
146regulation of striated muscle contraction (GO:0006942)2.05762377
147urinary tract smooth muscle contraction (GO:0014848)2.05686609
148neuron cell-cell adhesion (GO:0007158)2.04813406
149negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.04245681
150response to epinephrine (GO:0071871)2.04117373
151synaptic vesicle maturation (GO:0016188)2.03372381
152behavioral response to cocaine (GO:0048148)2.02773270
153regulation of muscle hypertrophy (GO:0014743)2.02285718
154multicellular organism reproduction (GO:0032504)2.00732225
155aggressive behavior (GO:0002118)2.00513867
156membrane depolarization during action potential (GO:0086010)2.00240846
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.00045328
158positive regulation of potassium ion transmembrane transport (GO:1901381)2.00032236
159righting reflex (GO:0060013)1.99685564
160regulation of actin filament-based movement (GO:1903115)1.99089671
161synaptic vesicle docking involved in exocytosis (GO:0016081)1.98716192
162long-term synaptic potentiation (GO:0060291)1.98614128
163regulation of synaptic vesicle transport (GO:1902803)1.98504561
164sarcomere organization (GO:0045214)1.98495686
165regulation of vesicle fusion (GO:0031338)1.98109835
166regulation of voltage-gated calcium channel activity (GO:1901385)1.98088808
167photoreceptor cell differentiation (GO:0046530)1.97474035
168eye photoreceptor cell differentiation (GO:0001754)1.97474035
169neurotransmitter secretion (GO:0007269)1.97031521
170regulation of cardiac muscle cell contraction (GO:0086004)1.96817139
171calcium ion-dependent exocytosis (GO:0017156)1.96345091
172neurotransmitter catabolic process (GO:0042135)1.95651511
173positive regulation of cation channel activity (GO:2001259)1.95251282
174piRNA metabolic process (GO:0034587)1.94155436
175ionotropic glutamate receptor signaling pathway (GO:0035235)1.93696836
176adrenergic receptor signaling pathway (GO:0071875)1.93289270
177regulation of muscle adaptation (GO:0043502)1.93273076
178epithelial cilium movement (GO:0003351)1.92917773
179glutamate receptor signaling pathway (GO:0007215)1.92405299
180regulation of glutamate receptor signaling pathway (GO:1900449)1.91862727
181positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.91808917
182actin-mediated cell contraction (GO:0070252)1.91726366
183parturition (GO:0007567)1.91452428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.22017371
2GBX2_23144817_ChIP-Seq_PC3_Human3.08185844
3WT1_19549856_ChIP-ChIP_CCG9911_Human2.19720961
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.16494139
5TAF15_26573619_Chip-Seq_HEK293_Human2.13510152
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07999039
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.01737069
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.00380025
9POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97600287
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97342408
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91089838
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89314418
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89219205
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85995832
15EWS_26573619_Chip-Seq_HEK293_Human1.85655021
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.84787430
17AR_21572438_ChIP-Seq_LNCaP_Human1.84485260
18SMAD4_21799915_ChIP-Seq_A2780_Human1.79420405
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79119546
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78822107
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75886714
22* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72530132
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71824628
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69020026
25P300_19829295_ChIP-Seq_ESCs_Human1.67560470
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65083941
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63165300
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60629793
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59616447
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58504782
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55432589
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55120728
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53351982
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52774257
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52774257
36BCAT_22108803_ChIP-Seq_LS180_Human1.50193766
37FUS_26573619_Chip-Seq_HEK293_Human1.50063259
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48498836
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48498836
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.46021300
41BRD4_25478319_ChIP-Seq_HGPS_Human1.45277442
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45234299
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44204178
44TP53_16413492_ChIP-PET_HCT116_Human1.41082685
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40099517
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39896474
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39546180
48AR_25329375_ChIP-Seq_VCAP_Human1.39340660
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37588481
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37513815
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35811867
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.34669844
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34011783
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33828576
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33267950
56CJUN_26792858_Chip-Seq_BT549_Human1.32934473
57TP53_18474530_ChIP-ChIP_U2OS_Human1.32674590
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31790580
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30908994
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.30601494
61STAT3_23295773_ChIP-Seq_U87_Human1.30174917
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30035365
63IGF1R_20145208_ChIP-Seq_DFB_Human1.28653231
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.28318378
65ER_23166858_ChIP-Seq_MCF-7_Human1.26694197
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25561839
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23167382
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21380897
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20898223
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20759834
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.20052432
72ZNF274_21170338_ChIP-Seq_K562_Hela1.18658461
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18034302
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17847515
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.17649394
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17260305
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16672333
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.16480228
79KDM2B_26808549_Chip-Seq_REH_Human1.15920618
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.15512630
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.15481397
82VDR_22108803_ChIP-Seq_LS180_Human1.15351705
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.13933820
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13608497
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13449190
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11926991
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.11488663
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10613023
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10157860
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.10037756
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09873567
92* TCF4_23295773_ChIP-Seq_U87_Human1.09624492
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.09027908
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08412375
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07313971
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05761258
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05755045
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04953138
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.04640976
100DROSHA_22980978_ChIP-Seq_HELA_Human1.04591640
101* CDX2_22108803_ChIP-Seq_LS180_Human1.04466175
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04164203
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03602824
104JUN_21703547_ChIP-Seq_K562_Human1.03109137
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03010769
106AHR_22903824_ChIP-Seq_MCF-7_Human1.02349944
107* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01330036
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01218245
109CBP_20019798_ChIP-Seq_JUKART_Human1.01218245
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.00331564
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00140537
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99199543
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.98798775
114P53_22387025_ChIP-Seq_ESCs_Mouse0.98165892
115BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97987881
116FLI1_21867929_ChIP-Seq_TH2_Mouse0.97442448
117* RUNX2_22187159_ChIP-Seq_PCA_Human0.97413664
118TAL1_26923725_Chip-Seq_HPCs_Mouse0.96015378
119RNF2_27304074_Chip-Seq_NSC_Mouse0.95140865
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.94670997
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94166152
122TCF4_18268006_ChIP-ChIP_LS174T_Human0.94022085

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.49557619
2MP0003136_yellow_coat_color2.93989894
3MP0000751_myopathy2.91366976
4MP0003646_muscle_fatigue2.80484472
5MP0005171_absent_coat_pigmentation2.57159998
6MP0004859_abnormal_synaptic_plasticity2.52810790
7MP0004145_abnormal_muscle_electrophysio2.39254263
8MP0000749_muscle_degeneration2.38526419
9MP0004215_abnormal_myocardial_fiber2.36217661
10MP0003880_abnormal_central_pattern2.32050791
11MP0005646_abnormal_pituitary_gland2.13921317
12MP0004036_abnormal_muscle_relaxation2.12740126
13MP0004484_altered_response_of2.12706567
14MP0004270_analgesia1.95492047
15MP0009384_cardiac_valve_regurgitation1.93487011
16MP0005503_abnormal_tendon_morphology1.92752946
17MP0010368_abnormal_lymphatic_system1.89841997
18MP0001501_abnormal_sleep_pattern1.88795575
19MP0002736_abnormal_nociception_after1.87096796
20MP0003635_abnormal_synaptic_transmissio1.86398160
21MP0005620_abnormal_muscle_contractility1.86186418
22MP0001968_abnormal_touch/_nociception1.80612695
23MP0008438_abnormal_cutaneous_collagen1.80362024
24MP0009046_muscle_twitch1.77913789
25MP0000013_abnormal_adipose_tissue1.76445768
26MP0009745_abnormal_behavioral_response1.72896480
27MP0001958_emphysema1.70760874
28MP0004130_abnormal_muscle_cell1.69007158
29MP0005187_abnormal_penis_morphology1.68420694
30MP0004084_abnormal_cardiac_muscle1.65628330
31MP0005275_abnormal_skin_tensile1.62532896
32MP0002972_abnormal_cardiac_muscle1.61373132
33MP0009780_abnormal_chondrocyte_physiolo1.60650612
34MP0002009_preneoplasia1.57998142
35MP0010386_abnormal_urinary_bladder1.56719263
36MP0008775_abnormal_heart_ventricle1.50535342
37MP0003950_abnormal_plasma_membrane1.49959712
38MP0004085_abnormal_heartbeat1.49628603
39MP0002063_abnormal_learning/memory/cond1.49444317
40MP0002572_abnormal_emotion/affect_behav1.49057000
41MP0006054_spinal_hemorrhage1.48490217
42MP0003705_abnormal_hypodermis_morpholog1.47072693
43MP0002234_abnormal_pharynx_morphology1.46587134
44MP0002928_abnormal_bile_duct1.43676878
45MP0002282_abnormal_trachea_morphology1.42073963
46MP0010030_abnormal_orbit_morphology1.39396743
47MP0001984_abnormal_olfaction1.37839349
48MP0002822_catalepsy1.37494268
49MP0001542_abnormal_bone_strength1.35686614
50MP0000733_abnormal_muscle_development1.35015887
51MP0002064_seizures1.34292250
52MP0002108_abnormal_muscle_morphology1.33608591
53MP0002734_abnormal_mechanical_nocicepti1.33516831
54MP0001440_abnormal_grooming_behavior1.31987489
55MP0005410_abnormal_fertilization1.30952302
56MP0002295_abnormal_pulmonary_circulatio1.29217040
57MP0002272_abnormal_nervous_system1.26713843
58MP0000762_abnormal_tongue_morphology1.25876443
59MP0003279_aneurysm1.25074278
60MP0008875_abnormal_xenobiotic_pharmacok1.24976749
61MP0005330_cardiomyopathy1.24608153
62MP0004087_abnormal_muscle_fiber1.23940394
63MP0002090_abnormal_vision1.21944949
64MP0002106_abnormal_muscle_physiology1.20784562
65MP0001502_abnormal_circadian_rhythm1.20140126
66MP0000569_abnormal_digit_pigmentation1.19866100
67MP0005595_abnormal_vascular_smooth1.18630130
68MP0003755_abnormal_palate_morphology1.18511990
69MP0005369_muscle_phenotype1.18058548
70MP0000230_abnormal_systemic_arterial1.17797638
71MP0000750_abnormal_muscle_regeneration1.17276328
72MP0000747_muscle_weakness1.17222788
73MP0006276_abnormal_autonomic_nervous1.16370230
74MP0002332_abnormal_exercise_endurance1.15314172
75MP0001486_abnormal_startle_reflex1.15306152
76MP0002638_abnormal_pupillary_reflex1.13725212
77MP0002938_white_spotting1.13652627
78MP0006138_congestive_heart_failure1.13474827
79MP0003045_fibrosis1.09889178
80MP0003283_abnormal_digestive_organ1.08785644
81MP0005085_abnormal_gallbladder_physiolo1.08013146
82MP0005623_abnormal_meninges_morphology1.05556197
83MP0002067_abnormal_sensory_capabilities1.04261652
84MP0005084_abnormal_gallbladder_morpholo1.01287533
85MP0005670_abnormal_white_adipose1.00682949
86MP0009697_abnormal_copulation0.99759190
87MP0005508_abnormal_skeleton_morphology0.99025739
88MP0001177_atelectasis0.98689136
89MP0001905_abnormal_dopamine_level0.97321771
90MP0004233_abnormal_muscle_weight0.96944878
91MP0000534_abnormal_ureter_morphology0.96931709
92MP0003137_abnormal_impulse_conducting0.96919789
93MP0002909_abnormal_adrenal_gland0.96634811
94MP0000003_abnormal_adipose_tissue0.96033205
95MP0004134_abnormal_chest_morphology0.95432213
96MP0004147_increased_porphyrin_level0.95270618
97MP0002127_abnormal_cardiovascular_syste0.94642893
98MP0008004_abnormal_stomach_pH0.94472814
99MP0002735_abnormal_chemical_nociception0.93867920
100MP0005386_behavior/neurological_phenoty0.93778308
101MP0004924_abnormal_behavior0.93778308
102MP0001299_abnormal_eye_distance/0.92268577
103MP0005167_abnormal_blood-brain_barrier0.91876576
104MP0002896_abnormal_bone_mineralization0.90221628
105MP0000049_abnormal_middle_ear0.90043214
106MP0001544_abnormal_cardiovascular_syste0.89916051
107MP0005385_cardiovascular_system_phenoty0.89916051
108MP0000759_abnormal_skeletal_muscle0.88727637
109MP0006072_abnormal_retinal_apoptosis0.88504608
110MP0002102_abnormal_ear_morphology0.87816844
111MP0002557_abnormal_social/conspecific_i0.87750987
112MP0002139_abnormal_hepatobiliary_system0.87585680
113MP0009053_abnormal_anal_canal0.86835434
114MP0005535_abnormal_body_temperature0.85954902
115MP0004510_myositis0.85346554
116MP0002269_muscular_atrophy0.85161484
117MP0004883_abnormal_blood_vessel0.83575220
118MP0002128_abnormal_blood_circulation0.82550135
119MP0003091_abnormal_cell_migration0.82425341
120MP0003935_abnormal_craniofacial_develop0.81807209
121MP0005164_abnormal_response_to0.81170364
122MP0005365_abnormal_bile_salt0.80979972
123MP0003941_abnormal_skin_development0.79957500
124MP0001879_abnormal_lymphatic_vessel0.79646844
125MP0001485_abnormal_pinna_reflex0.79499673
126MP0003787_abnormal_imprinting0.79492013
127MP0005165_increased_susceptibility_to0.79195653
128MP0009250_abnormal_appendicular_skeleto0.78934615
129MP0000767_abnormal_smooth_muscle0.78870413
130MP0000343_altered_response_to0.78704489
131MP0003937_abnormal_limbs/digits/tail_de0.78422944
132MP0008874_decreased_physiological_sensi0.78314661
133MP0004272_abnormal_basement_membrane0.78274157
134MP0003690_abnormal_glial_cell0.78027210
135MP0003828_pulmonary_edema0.77622565
136MP0000579_abnormal_nail_morphology0.76090455
137MP0005023_abnormal_wound_healing0.74871555
138MP0000163_abnormal_cartilage_morphology0.74609508
139MP0005367_renal/urinary_system_phenotyp0.74175169
140MP0000516_abnormal_urinary_system0.74175169
141MP0002168_other_aberrant_phenotype0.69725639
142MP0010630_abnormal_cardiac_muscle0.68037187
143MP0000778_abnormal_nervous_system0.67771464
144MP0002160_abnormal_reproductive_system0.67083475
145MP0005253_abnormal_eye_physiology0.66991601
146MP0001529_abnormal_vocalization0.66366706

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.25765641
2Popliteal pterygium (HP:0009756)4.23716340
3Type 2 muscle fiber atrophy (HP:0003554)3.84377645
4Focal motor seizures (HP:0011153)3.55904376
5Exercise-induced myalgia (HP:0003738)3.53189029
6Calf muscle hypertrophy (HP:0008981)3.33922794
7Abnormality of the calf musculature (HP:0001430)3.33641460
8Muscle hypertrophy of the lower extremities (HP:0008968)3.24650861
9Abnormality of placental membranes (HP:0011409)3.20563759
10Amniotic constriction ring (HP:0009775)3.20563759
11Atrial fibrillation (HP:0005110)3.18694738
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.16310579
13Absent/shortened dynein arms (HP:0200106)3.16310579
14Sudden death (HP:0001699)3.08794819
15Muscle fiber atrophy (HP:0100295)3.03640907
16Primary atrial arrhythmia (HP:0001692)2.95415449
17Aplasia involving bones of the upper limbs (HP:0009823)2.92269523
18Aplasia of the phalanges of the hand (HP:0009802)2.92269523
19Aplasia involving bones of the extremities (HP:0009825)2.92269523
20Muscle fiber inclusion bodies (HP:0100299)2.92199735
21Soft skin (HP:0000977)2.92131705
22Abnormal respiratory motile cilium physiology (HP:0012261)2.90522675
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.89568940
24Muscle fiber splitting (HP:0003555)2.87711331
25Distal arthrogryposis (HP:0005684)2.84787218
26Depressed nasal tip (HP:0000437)2.81786730
27Delayed gross motor development (HP:0002194)2.75408720
28Hyporeflexia of lower limbs (HP:0002600)2.73544149
29Aplasia of the musculature (HP:0100854)2.72443070
30Supraventricular tachycardia (HP:0004755)2.69259050
31Abnormality of the ischium (HP:0003174)2.63005542
32Neonatal short-limb short stature (HP:0008921)2.62684937
33Supraventricular arrhythmia (HP:0005115)2.62619085
34Weak cry (HP:0001612)2.61382840
35Atonic seizures (HP:0010819)2.60508913
36Febrile seizures (HP:0002373)2.58500658
37Vascular tortuosity (HP:0004948)2.57021977
38Type 1 muscle fiber predominance (HP:0003803)2.52796929
39Broad metatarsal (HP:0001783)2.50524641
40Nemaline bodies (HP:0003798)2.49727213
41Insulin-resistant diabetes mellitus (HP:0000831)2.45231062
42Epileptic encephalopathy (HP:0200134)2.42863310
43Right ventricular cardiomyopathy (HP:0011663)2.40876198
44Arterial tortuosity (HP:0005116)2.40623322
45EMG: myopathic abnormalities (HP:0003458)2.39031755
46Hypoplastic ischia (HP:0003175)2.39019792
47Exercise-induced muscle cramps (HP:0003710)2.36027631
48Chronic bronchitis (HP:0004469)2.34438242
49Round ear (HP:0100830)2.32330171
50Follicular hyperkeratosis (HP:0007502)2.29262365
51Syncope (HP:0001279)2.27364216
52Increased variability in muscle fiber diameter (HP:0003557)2.27012264
53True hermaphroditism (HP:0010459)2.26421428
54Abnormal ciliary motility (HP:0012262)2.26112335
55Aortic dissection (HP:0002647)2.25533471
56Malignant hyperthermia (HP:0002047)2.24128471
57Focal seizures (HP:0007359)2.22647094
58Abnormal finger flexion creases (HP:0006143)2.21351250
59Rhinitis (HP:0012384)2.20557107
60Distal lower limb amyotrophy (HP:0008944)2.20439900
61Thin ribs (HP:0000883)2.19706094
62Congenital, generalized hypertrichosis (HP:0004540)2.18987592
63Papillary thyroid carcinoma (HP:0002895)2.18626248
64Prolonged QT interval (HP:0001657)2.17705042
65Absent phalangeal crease (HP:0006109)2.16919556
66Aortic aneurysm (HP:0004942)2.16716019
67Hyperventilation (HP:0002883)2.14993800
68Generalized tonic-clonic seizures (HP:0002069)2.11345538
69Limited hip movement (HP:0008800)2.10328532
70Neck muscle weakness (HP:0000467)2.09899265
71Hypoplasia of the iris (HP:0007676)2.09770196
72Fibular aplasia (HP:0002990)2.09644322
73Premature rupture of membranes (HP:0001788)2.09478581
74Lipoatrophy (HP:0100578)2.09102536
75Gowers sign (HP:0003391)2.07236522
76Infertility (HP:0000789)2.07099800
77Progressive cerebellar ataxia (HP:0002073)2.06816457
78Large for gestational age (HP:0001520)2.06217214
79Bone cyst (HP:0012062)2.04559050
80Left ventricular hypertrophy (HP:0001712)2.04260626
81Hemiparesis (HP:0001269)2.03195545
82Aplasia/Hypoplasia of the fibula (HP:0006492)2.03101079
83Pancreatic fibrosis (HP:0100732)2.03059224
84Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01277001
85Lower limb amyotrophy (HP:0007210)2.00922225
86Pterygium (HP:0001059)1.98474178
87Dysmetric saccades (HP:0000641)1.98342811
88Abnormality of skeletal muscle fiber size (HP:0012084)1.96387441
89Hip contracture (HP:0003273)1.95736732
90Toxemia of pregnancy (HP:0100603)1.94706950
91Muscular dystrophy (HP:0003560)1.94043033
92Hyperglycemia (HP:0003074)1.93710332
93Bradycardia (HP:0001662)1.92612470
94Myotonia (HP:0002486)1.92295231
95Oligomenorrhea (HP:0000876)1.92162695
96Protrusio acetabuli (HP:0003179)1.92098674
97Deformed tarsal bones (HP:0008119)1.91422527
98Abnormality of dentin (HP:0010299)1.91220207
99Subaortic stenosis (HP:0001682)1.90076878
100Abnormality of the left ventricular outflow tract (HP:0011103)1.90076878
101Gaze-evoked nystagmus (HP:0000640)1.89809705
102Calcaneovalgus deformity (HP:0001848)1.89797343
103Meningioma (HP:0002858)1.88999871
104Medial flaring of the eyebrow (HP:0010747)1.88633459
105Limb-girdle muscle weakness (HP:0003325)1.88600538
106Nonprogressive disorder (HP:0003680)1.86563138
107Male infertility (HP:0003251)1.86176120
108Striae distensae (HP:0001065)1.85204947
109Cholecystitis (HP:0001082)1.85070068
110Abnormal gallbladder physiology (HP:0012438)1.85070068
111Increased connective tissue (HP:0009025)1.84873967
112Hypoalphalipoproteinemia (HP:0003233)1.84632669
113Gait imbalance (HP:0002141)1.84258023
114Overgrowth (HP:0001548)1.82703856
115Bundle branch block (HP:0011710)1.82323235
116Congenital primary aphakia (HP:0007707)1.81712200
117Spinal rigidity (HP:0003306)1.81567218
118Fatigable weakness (HP:0003473)1.80092296
119Abnormality of the neuromuscular junction (HP:0003398)1.80092296
120Decreased muscle mass (HP:0003199)1.79015060
121Keratoconus (HP:0000563)1.77984246
122Increased corneal curvature (HP:0100692)1.77984246
123Limb-girdle muscle atrophy (HP:0003797)1.77948864
124Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77904805
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.77832391
126Absence seizures (HP:0002121)1.77818102
127Aortic regurgitation (HP:0001659)1.77534605
128Steppage gait (HP:0003376)1.76560323
129Pheochromocytoma (HP:0002666)1.76414981
130Spondylolisthesis (HP:0003302)1.76304411
131Mesomelia (HP:0003027)1.75764884
132Fibular hypoplasia (HP:0003038)1.74667516
133Ulnar claw (HP:0001178)1.74577633
134Pancreatic cysts (HP:0001737)1.74228612
135Tubular atrophy (HP:0000092)1.74145069
136Abnormality of the musculature of the pelvis (HP:0001469)1.73942668
137Abnormality of the hip-girdle musculature (HP:0001445)1.73942668
138Cortical dysplasia (HP:0002539)1.73603620
139Anxiety (HP:0000739)1.73404789
140Dysdiadochokinesis (HP:0002075)1.73161120
141Genital tract atresia (HP:0001827)1.72997852
142Retinal dysplasia (HP:0007973)1.72569143
143Aplasia/Hypoplasia of the lens (HP:0008063)1.71855728
144Rimmed vacuoles (HP:0003805)1.71826409
145Prominent supraorbital ridges (HP:0000336)1.71147328
146Wrist flexion contracture (HP:0001239)1.68142387
147Aortic valve stenosis (HP:0001650)1.68028446
148Knee flexion contracture (HP:0006380)1.67897147
149Chorioretinal atrophy (HP:0000533)1.66588256
150Scanning speech (HP:0002168)1.65609925
151Myokymia (HP:0002411)1.65463952
152Vaginal atresia (HP:0000148)1.65007925
153Ventricular arrhythmia (HP:0004308)1.64917638
154Fetal akinesia sequence (HP:0001989)1.64146292
155Difficulty climbing stairs (HP:0003551)1.63981542
156Abnormality of the anterior chamber (HP:0000593)1.63917951
157Molar tooth sign on MRI (HP:0002419)1.63472359
158Abnormality of midbrain morphology (HP:0002418)1.63472359
159Muscle stiffness (HP:0003552)1.62346205
160Facial diplegia (HP:0001349)1.62203604
161Infantile muscular hypotonia (HP:0008947)1.61295882
162Abnormal atrioventricular conduction (HP:0005150)1.60365258
163Difficulty running (HP:0009046)1.60022156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.88497610
2TSSK64.85022903
3WEE13.22906112
4MUSK2.90749551
5MAP3K42.79796890
6MAP2K72.59948203
7MAP3K62.36375882
8PDK42.33836921
9PDK32.33836921
10MAPKAPK52.29478866
11TAOK32.27660463
12PDK22.19946845
13OBSCN2.15537416
14EPHB22.13551842
15MAP2K41.98444090
16EPHA41.96704829
17CASK1.91254463
18NTRK31.89636779
19DMPK1.85816549
20PIK3CA1.71440829
21ERBB31.70686219
22MOS1.63566061
23MAP3K121.62982586
24LIMK11.60787444
25ERBB41.55696069
26FER1.54628944
27LATS11.52566399
28EIF2AK31.52475031
29VRK11.48649609
30MAP3K91.44472436
31GRK71.41996088
32PTK2B1.37628741
33BRSK21.36934506
34PHKG21.33430734
35PHKG11.33430734
36SGK21.29534588
37PAK21.29478808
38PLK21.29420735
39PINK11.28259671
40MAPK151.25490616
41BMPR21.23758723
42ARAF1.23156182
43PLK31.21592431
44TTN1.18514514
45FRK1.18488477
46AKT31.18163940
47EPHA31.16849796
48DDR21.15505837
49SGK2231.14547566
50SGK4941.14547566
51INSRR1.14361865
52CAMK2A1.13461853
53STK38L1.11515967
54NTRK21.09059017
55TGFBR11.08905130
56PRKD31.08024510
57MYLK1.07760555
58BRAF1.07558959
59PAK31.04516484
60LMTK21.04513233
61NEK91.02118041
62WNK40.96053057
63MKNK20.95956995
64MARK10.95810192
65LATS20.94696389
66CDK30.94221035
67MINK10.93968326
68KSR20.93294581
69SGK30.92441607
70BMPR1B0.92433311
71MAP3K130.89985170
72STK390.89741905
73TRPM70.87567653
74PIK3CG0.85951961
75PRKAA20.84940798
76NEK60.84938578
77CAMK2D0.83795507
78STK380.82167844
79DYRK30.81529499
80CCNB10.80973853
81WNK10.78937188
82RAF10.77097468
83RET0.76969725
84GRK50.75534783
85MAPK130.75420384
86ADRBK20.74758593
87STK30.72615561
88GSK3A0.72176800
89MAPK120.68687332
90CDK80.66689113
91MAP4K20.66538320
92WNK30.66337570
93PRKCE0.66258714
94PDGFRA0.64539298
95TGFBR20.64529278
96MAP3K50.64465259
97MET0.64375056
98MAPKAPK30.64072765
99PKN10.63108647
100CAMK2G0.63107870
101TAOK10.63040950
102NTRK10.62701232
103ROCK10.61990435
104GRK10.61883469
105CDK50.61870718
106BCR0.61750075
107OXSR10.61127827
108PRKCG0.61084858
109ZAK0.60050373
110ROCK20.58593294
111SGK10.57789808
112STK240.57755752
113MAP2K10.57621960
114MKNK10.57433068
115MST40.57177706
116CAMK1G0.56574202
117NUAK10.55958371
118MAP3K10.55471611
119PRKG10.55192618
120PTK20.55147935
121PRKAA10.54221114
122CAMKK20.54138717
123FGFR20.53591269
124PAK60.53503820
125TRIM280.51727274
126CAMK10.51254072
127FES0.49672089
128KSR10.47022332
129TIE10.46698685
130CAMK2B0.46681893
131ADRBK10.44504536
132TNIK0.43761294
133MAPK70.42956681
134ABL20.42588239
135CDK90.41976587
136DAPK20.40502985
137EIF2AK20.39795165
138PDGFRB0.37302590
139PRKD10.36258240
140ACVR1B0.35551664
141EIF2AK10.35240460
142NEK10.32320578
143ABL10.29912385

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.68218478
2Nicotine addiction_Homo sapiens_hsa050332.08468022
3Dilated cardiomyopathy_Homo sapiens_hsa054141.87400387
4Hedgehog signaling pathway_Homo sapiens_hsa043401.76071932
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74481364
6GABAergic synapse_Homo sapiens_hsa047271.72416426
7Circadian entrainment_Homo sapiens_hsa047131.69437090
8Renin secretion_Homo sapiens_hsa049241.69197622
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69098546
10Hippo signaling pathway_Homo sapiens_hsa043901.66380656
11Basal cell carcinoma_Homo sapiens_hsa052171.60725779
12Amphetamine addiction_Homo sapiens_hsa050311.55920483
13Morphine addiction_Homo sapiens_hsa050321.55236500
14Circadian rhythm_Homo sapiens_hsa047101.52012195
15Synaptic vesicle cycle_Homo sapiens_hsa047211.50403225
16Glutamatergic synapse_Homo sapiens_hsa047241.50180760
17Olfactory transduction_Homo sapiens_hsa047401.46782739
18Ovarian steroidogenesis_Homo sapiens_hsa049131.44493331
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43617601
20Insulin secretion_Homo sapiens_hsa049111.40284183
21Protein digestion and absorption_Homo sapiens_hsa049741.37528486
22Dorso-ventral axis formation_Homo sapiens_hsa043201.36345357
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33112909
24Propanoate metabolism_Homo sapiens_hsa006401.32699521
25Salivary secretion_Homo sapiens_hsa049701.29897214
26Cocaine addiction_Homo sapiens_hsa050301.29806546
27Serotonergic synapse_Homo sapiens_hsa047261.27438464
28Collecting duct acid secretion_Homo sapiens_hsa049661.27288876
29Oxytocin signaling pathway_Homo sapiens_hsa049211.25930958
30Calcium signaling pathway_Homo sapiens_hsa040201.22420072
31Taste transduction_Homo sapiens_hsa047421.21954418
32Long-term potentiation_Homo sapiens_hsa047201.21888022
33cAMP signaling pathway_Homo sapiens_hsa040241.20698270
34Dopaminergic synapse_Homo sapiens_hsa047281.18575428
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.18379524
36Cardiac muscle contraction_Homo sapiens_hsa042601.18114598
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17383669
38Long-term depression_Homo sapiens_hsa047301.16200157
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15960176
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14779595
41Parkinsons disease_Homo sapiens_hsa050121.13616413
42Phototransduction_Homo sapiens_hsa047441.13476926
43Folate biosynthesis_Homo sapiens_hsa007901.11917401
44Selenocompound metabolism_Homo sapiens_hsa004501.11517951
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.10466677
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10079494
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08497625
48Gastric acid secretion_Homo sapiens_hsa049711.07193354
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06550181
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05238191
51Basal transcription factors_Homo sapiens_hsa030221.04946528
52Cholinergic synapse_Homo sapiens_hsa047251.04275458
53GnRH signaling pathway_Homo sapiens_hsa049121.02906623
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00941141
55PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00336309
56Tight junction_Homo sapiens_hsa045301.00057569
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99535393
58Proteoglycans in cancer_Homo sapiens_hsa052050.97730293
59Prion diseases_Homo sapiens_hsa050200.97668558
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96454634
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94102556
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93248566
63Butanoate metabolism_Homo sapiens_hsa006500.92312259
64Fatty acid degradation_Homo sapiens_hsa000710.92262621
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90148635
66ECM-receptor interaction_Homo sapiens_hsa045120.89096813
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87592089
68Pyruvate metabolism_Homo sapiens_hsa006200.86417602
69Adherens junction_Homo sapiens_hsa045200.85281328
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82967648
71Glucagon signaling pathway_Homo sapiens_hsa049220.82851501
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82332151
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82000845
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81241498
75PPAR signaling pathway_Homo sapiens_hsa033200.80531317
76Arginine biosynthesis_Homo sapiens_hsa002200.79955587
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79819154
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79804726
79Wnt signaling pathway_Homo sapiens_hsa043100.78758784
80Legionellosis_Homo sapiens_hsa051340.77927461
81Fatty acid metabolism_Homo sapiens_hsa012120.76088947
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75164425
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73410520
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73268933
85Estrogen signaling pathway_Homo sapiens_hsa049150.72642795
86Type II diabetes mellitus_Homo sapiens_hsa049300.71845894
87Rheumatoid arthritis_Homo sapiens_hsa053230.71435221
88Mineral absorption_Homo sapiens_hsa049780.70167287
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70132654
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.69661336
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69646173
92Gap junction_Homo sapiens_hsa045400.69190570
93Steroid biosynthesis_Homo sapiens_hsa001000.68672467
94p53 signaling pathway_Homo sapiens_hsa041150.68631552
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68273501
96Pathways in cancer_Homo sapiens_hsa052000.67814589
97Ether lipid metabolism_Homo sapiens_hsa005650.67318255
98Nitrogen metabolism_Homo sapiens_hsa009100.66215971
99Vibrio cholerae infection_Homo sapiens_hsa051100.65244529
100Huntingtons disease_Homo sapiens_hsa050160.64681993
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64341109
102Focal adhesion_Homo sapiens_hsa045100.62381925
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62359798
104MAPK signaling pathway_Homo sapiens_hsa040100.61387567
105Melanoma_Homo sapiens_hsa052180.60519011
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60070016
107Bile secretion_Homo sapiens_hsa049760.59935098
108Fatty acid elongation_Homo sapiens_hsa000620.59685054
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59015134
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58565865
111Pancreatic secretion_Homo sapiens_hsa049720.58022994
112Ras signaling pathway_Homo sapiens_hsa040140.57421275
113Complement and coagulation cascades_Homo sapiens_hsa046100.57214943
114Sulfur metabolism_Homo sapiens_hsa009200.56597425
115ErbB signaling pathway_Homo sapiens_hsa040120.54059106
116Amoebiasis_Homo sapiens_hsa051460.54004603
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53631399
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53506550
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.52300903
120Peroxisome_Homo sapiens_hsa041460.50255606
121Fatty acid biosynthesis_Homo sapiens_hsa000610.49968918
122Starch and sucrose metabolism_Homo sapiens_hsa005000.49915452
123Malaria_Homo sapiens_hsa051440.49300064
124Caffeine metabolism_Homo sapiens_hsa002320.48719463
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47338468
126Insulin resistance_Homo sapiens_hsa049310.47308306
127Linoleic acid metabolism_Homo sapiens_hsa005910.47277526
128TGF-beta signaling pathway_Homo sapiens_hsa043500.46825681
129Thyroid hormone synthesis_Homo sapiens_hsa049180.46690302
130Axon guidance_Homo sapiens_hsa043600.46006588
131Melanogenesis_Homo sapiens_hsa049160.45589180
132Choline metabolism in cancer_Homo sapiens_hsa052310.44759194
133Platelet activation_Homo sapiens_hsa046110.43618336
134ABC transporters_Homo sapiens_hsa020100.43226114
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42439179
136Small cell lung cancer_Homo sapiens_hsa052220.41802624
137Alzheimers disease_Homo sapiens_hsa050100.41243425
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39823485
139Oxidative phosphorylation_Homo sapiens_hsa001900.39308545
140Tryptophan metabolism_Homo sapiens_hsa003800.38388956
141FoxO signaling pathway_Homo sapiens_hsa040680.37764305

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