DNAJB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of striated muscle cell apoptotic process (GO:0010664)8.46089869
2cellular response to heat (GO:0034605)7.13096082
3* negative regulation of inclusion body assembly (GO:0090084)6.83985067
4cellular response to arsenic-containing substance (GO:0071243)5.76234658
5neuron fate determination (GO:0048664)5.76138636
6regulation of striated muscle cell apoptotic process (GO:0010662)5.65186259
7regulation of MHC class I biosynthetic process (GO:0045343)5.57876721
8heart valve formation (GO:0003188)5.38577823
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.20594424
10positive regulation of extracellular matrix organization (GO:1903055)5.05264498
11spinal cord development (GO:0021510)4.79959309
12virion assembly (GO:0019068)4.59082163
13chaperone-mediated protein complex assembly (GO:0051131)4.54713914
142-deoxyribonucleotide biosynthetic process (GO:0009265)4.46482534
15deoxyribose phosphate biosynthetic process (GO:0046385)4.46482534
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.40796150
17axon ensheathment in central nervous system (GO:0032291)4.38122380
18central nervous system myelination (GO:0022010)4.38122380
19endocardial cushion morphogenesis (GO:0003203)4.37769564
20* response to unfolded protein (GO:0006986)4.29706196
21interferon-gamma secretion (GO:0072643)4.28294386
22response to heat (GO:0009408)4.23778439
23* regulation of inclusion body assembly (GO:0090083)4.20100435
24* response to topologically incorrect protein (GO:0035966)4.14605378
25neuronal stem cell maintenance (GO:0097150)4.11460579
26pattern specification involved in kidney development (GO:0061004)4.01132978
27negative regulation of muscle cell apoptotic process (GO:0010656)4.00344753
28negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.00267245
29* protein refolding (GO:0042026)3.99296580
30positive regulation of Notch signaling pathway (GO:0045747)3.89571042
31mesenchyme morphogenesis (GO:0072132)3.82397351
32negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.79748507
33type B pancreatic cell proliferation (GO:0044342)3.78866263
34SMAD protein signal transduction (GO:0060395)3.77555293
35negative regulation of oligodendrocyte differentiation (GO:0048715)3.75264736
36nephron epithelium morphogenesis (GO:0072088)3.64386887
37nephron tubule morphogenesis (GO:0072078)3.64386887
38intermediate filament organization (GO:0045109)3.63806570
39ubiquinone biosynthetic process (GO:0006744)3.60754734
40regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.59568121
41positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.59568121
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57109463
43antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57109463
44fusion of sperm to egg plasma membrane (GO:0007342)3.48571615
45neural crest cell development (GO:0014032)3.48355733
46ribosomal small subunit assembly (GO:0000028)3.47639475
47positive thymic T cell selection (GO:0045059)3.45520239
48DNA deamination (GO:0045006)3.44995161
49ubiquinone metabolic process (GO:0006743)3.43671084
50Notch signaling involved in heart development (GO:0061314)3.38836054
51sperm motility (GO:0030317)3.31872704
52forebrain neuron differentiation (GO:0021879)3.28994604
53* chaperone mediated protein folding requiring cofactor (GO:0051085)3.28665700
54purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.27249606
55regulation of mesenchymal cell apoptotic process (GO:2001053)3.26603333
56endothelial cell chemotaxis (GO:0035767)3.26494081
57positive regulation of astrocyte differentiation (GO:0048711)3.25350478
58cochlea development (GO:0090102)3.24053950
59binding of sperm to zona pellucida (GO:0007339)3.21892337
60regulation of synapse structural plasticity (GO:0051823)3.21844268
61antigen processing and presentation of endogenous antigen (GO:0019883)3.18989774
62labyrinthine layer blood vessel development (GO:0060716)3.17776250
63sperm-egg recognition (GO:0035036)3.15864913
64maturation of SSU-rRNA (GO:0030490)3.15786379
65negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.11677295
66positive regulation of mRNA catabolic process (GO:0061014)3.09553103
67positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.08186300
68regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.08186300
69NIK/NF-kappaB signaling (GO:0038061)3.07300063
70viral protein processing (GO:0019082)3.05341513
71mesenchymal cell development (GO:0014031)3.03637907
72regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.02999409
73Notch receptor processing (GO:0007220)3.02291925
74viral transcription (GO:0019083)3.01175979
75behavioral response to nicotine (GO:0035095)3.00033403
76amino acid import (GO:0043090)2.97658231
77RNA destabilization (GO:0050779)2.95759636
78telencephalon development (GO:0021537)2.92295079
79response to gravity (GO:0009629)2.91683885
80keratinocyte proliferation (GO:0043616)2.90662864
81translational termination (GO:0006415)2.89791223
82cell-cell recognition (GO:0009988)2.89603649
83extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.89445699
84interferon-gamma production (GO:0032609)2.89174080
85regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618)2.86863877
86COPI coating of Golgi vesicle (GO:0048205)2.86796313
87Golgi transport vesicle coating (GO:0048200)2.86796313
88positive T cell selection (GO:0043368)2.85944618
89cell proliferation involved in kidney development (GO:0072111)2.85811944
90definitive hemopoiesis (GO:0060216)2.85353441
91nephron tubule formation (GO:0072079)2.84491256
92tolerance induction (GO:0002507)2.82297724
93quinone biosynthetic process (GO:1901663)2.82189366
94regulation of mRNA catabolic process (GO:0061013)2.80882134
95positive regulation of erythrocyte differentiation (GO:0045648)2.80207789
96SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79929564
97negative regulation of myoblast differentiation (GO:0045662)2.78953518
98regulation of gamma-delta T cell differentiation (GO:0045586)2.77903736
99cilium or flagellum-dependent cell motility (GO:0001539)2.76751767
100regulation of extracellular matrix organization (GO:1903053)2.74916568
101regulation of cell proliferation involved in kidney development (GO:1901722)2.73908367
102signal transduction in absence of ligand (GO:0038034)2.73871989
103extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)2.73871989
104multicellular organism reproduction (GO:0032504)2.73538371
105thymic T cell selection (GO:0045061)2.73471146
106endoderm formation (GO:0001706)2.73044921
107stem cell development (GO:0048864)2.73022886
108cotranslational protein targeting to membrane (GO:0006613)2.73007013
109ribosomal small subunit biogenesis (GO:0042274)2.72261924
110piRNA metabolic process (GO:0034587)2.72002475
111protein targeting to ER (GO:0045047)2.71787193
112astrocyte differentiation (GO:0048708)2.71614008
113* protein folding (GO:0006457)2.71388110
114negative regulation of protein autophosphorylation (GO:0031953)2.70359093
115cell proliferation involved in metanephros development (GO:0072203)2.69252546
116regulation of DNA-templated transcription in response to stress (GO:0043620)2.61818084
117regulation of timing of cell differentiation (GO:0048505)2.59913605
118negative regulation of glial cell differentiation (GO:0045686)2.59590049
119positive regulation of male gonad development (GO:2000020)2.59293900
120hemidesmosome assembly (GO:0031581)2.58405534
121deoxyribonucleotide biosynthetic process (GO:0009263)2.57867059
122heart valve morphogenesis (GO:0003179)2.56120683
123negative regulation of fatty acid transport (GO:2000192)2.56008095
124protein localization to endoplasmic reticulum (GO:0070972)2.55668689
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55657589
126megakaryocyte development (GO:0035855)2.55450040
1273-UTR-mediated mRNA stabilization (GO:0070935)2.55378805
128translational elongation (GO:0006414)2.55092936
129negative regulation of glycoprotein biosynthetic process (GO:0010561)2.55072290
130heart trabecula morphogenesis (GO:0061384)2.53738089
131radial glial cell differentiation (GO:0060019)2.53580172
132reproduction (GO:0000003)2.53501483
133dopamine biosynthetic process (GO:0042416)2.53035463
134notochord development (GO:0030903)2.53008822
135renal system development (GO:0072001)2.52420961
136response to muramyl dipeptide (GO:0032495)2.51197939
137GDP-mannose metabolic process (GO:0019673)2.51106507
138signal complex assembly (GO:0007172)2.50484141
139photoreceptor cell differentiation (GO:0046530)2.50274843
140eye photoreceptor cell differentiation (GO:0001754)2.50274843
141neuroblast proliferation (GO:0007405)2.49712666
142regulation of astrocyte differentiation (GO:0048710)2.49654842
143viral life cycle (GO:0019058)2.49248626
144positive regulation by host of viral transcription (GO:0043923)2.48820126
145spermatid development (GO:0007286)2.47692339
146ventricular septum morphogenesis (GO:0060412)2.46880521
147endothelial cell differentiation (GO:0045446)2.45523828
148positive regulation of gamma-delta T cell activation (GO:0046645)2.44921828
149regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44533119
150regulation of T cell tolerance induction (GO:0002664)2.42372112
151JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39690034
152nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39662500
153regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.39163534
154trophectodermal cell differentiation (GO:0001829)2.38988633
155regulation of gamma-delta T cell activation (GO:0046643)2.38750541
156antigen processing and presentation via MHC class Ib (GO:0002475)2.38070751
157interleukin-6-mediated signaling pathway (GO:0070102)2.37315880
158plasma membrane fusion (GO:0045026)2.37294691
159positive regulation of mRNA 3-end processing (GO:0031442)2.35374681
160positive regulation of tolerance induction (GO:0002645)2.34387049
161T cell differentiation (GO:0030217)2.33689719
162regulation of erythrocyte differentiation (GO:0045646)2.33687351
163regulation of cytokine production involved in inflammatory response (GO:1900015)2.33621848
164hepatocyte apoptotic process (GO:0097284)2.33181760
165response to progesterone (GO:0032570)2.32755827
166negative regulation of erythrocyte differentiation (GO:0045647)2.31555387
167T cell selection (GO:0045058)2.31331312
168regulation of monocyte differentiation (GO:0045655)2.30281863
169regulation of spindle checkpoint (GO:0090231)2.28523257
170regulation of response to interferon-gamma (GO:0060330)2.27731385
171skin morphogenesis (GO:0043589)2.26578810
172mature B cell differentiation involved in immune response (GO:0002313)2.26286654
173polyamine biosynthetic process (GO:0006596)2.25966358
174immunoglobulin mediated immune response (GO:0016064)2.24820179
175translational initiation (GO:0006413)2.24348976
176negative regulation of JUN kinase activity (GO:0043508)2.24330270
177negative T cell selection (GO:0043383)2.23289143
178regulation of histone H3-K27 methylation (GO:0061085)2.23267671
179axonemal dynein complex assembly (GO:0070286)2.21854931
180mRNA catabolic process (GO:0006402)2.21568313
181negative regulation of gluconeogenesis (GO:0045721)2.21116018
182negative regulation of necroptotic process (GO:0060546)2.18495565
183positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.18217720
184cellular protein complex disassembly (GO:0043624)2.17351963
185ribosomal large subunit biogenesis (GO:0042273)2.17288819
186interleukin-1-mediated signaling pathway (GO:0070498)2.17193830
187regulation of necroptotic process (GO:0060544)2.17174762
188trophoblast giant cell differentiation (GO:0060707)2.17004451
189nuclear-transcribed mRNA catabolic process (GO:0000956)2.16816870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.76524878
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.59133378
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62998208
4E2F7_22180533_ChIP-Seq_HELA_Human3.50569386
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.38668772
6NOTCH1_21737748_ChIP-Seq_TLL_Human3.29159967
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.79847452
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.78601985
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73044422
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69349075
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53820678
12SCL_19346495_ChIP-Seq_HPC-7_Human2.49515657
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.41629954
14MYC_22102868_ChIP-Seq_BL_Human2.38985425
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.27775818
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.27775818
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.27775818
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23614546
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.22677338
20* MYB_26560356_Chip-Seq_TH2_Human2.15450471
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.12969921
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00171109
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00108323
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99109572
25* MAF_26560356_Chip-Seq_TH1_Human1.97809252
26* TCF7_22412390_ChIP-Seq_EML_Mouse1.95903026
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94856107
28* MYB_26560356_Chip-Seq_TH1_Human1.93789597
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.91633295
30* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90045061
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.88543728
32* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.86377397
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84376364
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83912711
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81369239
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80264781
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79684659
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79660713
39* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75087004
40RUNX_20019798_ChIP-Seq_JUKART_Human1.72096181
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71932769
42UTX_26944678_Chip-Seq_JUKART_Human1.67218934
43* VDR_23849224_ChIP-Seq_CD4+_Human1.65434173
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64833749
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.61276645
46VDR_21846776_ChIP-Seq_THP-1_Human1.60902745
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59085251
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.57670846
49VDR_24763502_ChIP-Seq_THP-1_Human1.57503475
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.55018616
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53207048
52MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50718077
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50079079
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49325438
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.47812716
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.47187806
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.46232762
58XRN2_22483619_ChIP-Seq_HELA_Human1.44994933
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44222437
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.42283721
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41813956
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40887355
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.40730282
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37949147
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37122946
66* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33445078
67* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33229216
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32882328
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.30843462
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30480088
71SPI1_23547873_ChIP-Seq_NB4_Human1.29365911
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28854387
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.28279704
74* CLOCK_20551151_ChIP-Seq_293T_Human1.28096673
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28055859
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25976862
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25780083
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25751372
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24999450
80MAF_26560356_Chip-Seq_TH2_Human1.24932293
81GATA3_27048872_Chip-Seq_THYMUS_Human1.24683056
82ELK3_25401928_ChIP-Seq_HUVEC_Human1.24211080
83TTF2_22483619_ChIP-Seq_HELA_Human1.21851167
84DCP1A_22483619_ChIP-Seq_HELA_Human1.20819958
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19883778
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19118083
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18292514
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17527587
89SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17278031
90* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16922590
91E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16796860
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16620403
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16595705
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15425295
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.15003902
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14980432
97EZH2_22144423_ChIP-Seq_EOC_Human1.13933124
98* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13568571
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13539404
100* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13504435
101* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13037526
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12925889
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11964099
104* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11934776
105* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11047389
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10949506
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10949506
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10657359
109* ATF3_27146783_Chip-Seq_COLON_Human1.10604122
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10056025
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10036188
112ZNF263_19887448_ChIP-Seq_K562_Human1.09776641
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09243037
114* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08982177
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08877623
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08119338
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08119338
118RUNX1_27514584_Chip-Seq_MCF-7_Human1.07950921
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07293187
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.06940555
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06868612
122* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06422028
123GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04880847
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03647379
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.03585582
126FOXM1_23109430_ChIP-Seq_U2OS_Human1.03143118
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02898667
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.01389696
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99894954
130GABP_17652178_ChIP-ChIP_JURKAT_Human0.99891627
131* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98021261
132CIITA_25753668_ChIP-Seq_RAJI_Human0.97959129
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97913076
134NCOR1_26117541_ChIP-Seq_K562_Human0.97309204
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94748998
136RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94392447
137FOXP3_21729870_ChIP-Seq_TREG_Human0.93322559
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93141656
139AR_21909140_ChIP-Seq_LNCAP_Human0.92768095
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.92538304
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.92014341
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91616635
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91430660
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.91376233
145KDM2B_26808549_Chip-Seq_K562_Human0.91294903
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90843329
147UBF1/2_26484160_Chip-Seq_HMECs_Human0.89777364
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89761626
149KDM2B_26808549_Chip-Seq_DND41_Human0.89506400
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89091757
151SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88965714
152EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87966991
153CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86935171
154SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83125251
155CTCF_20526341_ChIP-Seq_ESCs_Human0.82612387
156RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82043444
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81332288
158ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80748218
159OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80259766
160* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78129057
161RACK7_27058665_Chip-Seq_MCF-7_Human0.77522566
162CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77027180
163JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76454581
164CBX2_27304074_Chip-Seq_ESCs_Mouse0.75676208
165ETS1_20019798_ChIP-Seq_JURKAT_Human0.74674904
166TET1_21451524_ChIP-Seq_MESCs_Mouse0.74632582
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73800180
168LXR_22292898_ChIP-Seq_THP-1_Human0.73354145
169* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73111190

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.35216364
2MP0003806_abnormal_nucleotide_metabolis4.26835054
3MP0000749_muscle_degeneration3.87171236
4MP0002653_abnormal_ependyma_morphology3.80381619
5MP0003724_increased_susceptibility_to3.32069741
6MP0008007_abnormal_cellular_replicative3.29489876
7MP0003763_abnormal_thymus_physiology3.20635763
8MP0002877_abnormal_melanocyte_morpholog2.93156011
9MP0002928_abnormal_bile_duct2.86140780
10MP0003221_abnormal_cardiomyocyte_apopto2.69896076
11MP0003693_abnormal_embryo_hatching2.58919044
12MP0005410_abnormal_fertilization2.52697872
13MP0000343_altered_response_to2.25770802
14MP0001851_eye_inflammation2.21350568
15MP0009840_abnormal_foam_cell2.20405196
16MP0000762_abnormal_tongue_morphology2.18893554
17MP0002009_preneoplasia2.16954882
18MP0000566_synostosis2.07433538
19MP0010094_abnormal_chromosome_stability2.01912616
20MP0000685_abnormal_immune_system1.99543676
21MP0002277_abnormal_respiratory_mucosa1.97991706
22MP0002166_altered_tumor_susceptibility1.94590022
23MP0002405_respiratory_system_inflammati1.93431941
24MP0002249_abnormal_larynx_morphology1.88783670
25MP0005671_abnormal_response_to1.85301562
26MP0002396_abnormal_hematopoietic_system1.84479258
27MP0004264_abnormal_extraembryonic_tissu1.80990171
28MP0004808_abnormal_hematopoietic_stem1.80757184
29MP0008058_abnormal_DNA_repair1.79461496
30MP0004947_skin_inflammation1.75028460
31MP0002282_abnormal_trachea_morphology1.74958325
32MP0003315_abnormal_perineum_morphology1.74310958
33MP0003077_abnormal_cell_cycle1.71873063
34MP0000703_abnormal_thymus_morphology1.67482828
35MP0005423_abnormal_somatic_nervous1.66831622
36MP0005397_hematopoietic_system_phenotyp1.64366442
37MP0001545_abnormal_hematopoietic_system1.64366442
38MP0000465_gastrointestinal_hemorrhage1.62708055
39MP0000467_abnormal_esophagus_morphology1.61627759
40MP0002398_abnormal_bone_marrow1.59902598
41MP0001873_stomach_inflammation1.59004595
42MP0004742_abnormal_vestibular_system1.56749315
43MP0001800_abnormal_humoral_immune1.56669176
44MP0002723_abnormal_immune_serum1.55575630
45MP0002006_tumorigenesis1.55443347
46MP0003943_abnormal_hepatobiliary_system1.55206339
47MP0010352_gastrointestinal_tract_polyps1.53407638
48MP0002132_abnormal_respiratory_system1.52605517
49MP0006054_spinal_hemorrhage1.52296579
50MP0010155_abnormal_intestine_physiology1.51127235
51MP0003880_abnormal_central_pattern1.50697001
52MP0000579_abnormal_nail_morphology1.50169330
53MP0002822_catalepsy1.50082919
54MP0002420_abnormal_adaptive_immunity1.49742483
55MP0009278_abnormal_bone_marrow1.48473608
56MP0002254_reproductive_system_inflammat1.48146521
57MP0004885_abnormal_endolymph1.47948657
58MP0005000_abnormal_immune_tolerance1.46631753
59MP0008057_abnormal_DNA_replication1.45024402
60MP0003453_abnormal_keratinocyte_physiol1.44904857
61MP0001819_abnormal_immune_cell1.44766462
62MP0001835_abnormal_antigen_presentation1.44573620
63MP0000537_abnormal_urethra_morphology1.44328953
64MP0003638_abnormal_response/metabolism_1.42276354
65MP0001790_abnormal_immune_system1.41972612
66MP0005387_immune_system_phenotype1.41972612
67MP0001502_abnormal_circadian_rhythm1.41577334
68MP0003300_gastrointestinal_ulcer1.37655742
69MP0001929_abnormal_gametogenesis1.36743537
70MP0004142_abnormal_muscle_tone1.36338994
71MP0000490_abnormal_crypts_of1.35926388
72MP0002452_abnormal_antigen_presenting1.34963641
73MP0000716_abnormal_immune_system1.34449164
74MP0005084_abnormal_gallbladder_morpholo1.33616059
75MP0002722_abnormal_immune_system1.33573380
76MP0004957_abnormal_blastocyst_morpholog1.31045689
77MP0003866_abnormal_defecation1.30439215
78MP0003828_pulmonary_edema1.29546693
79MP0009333_abnormal_splenocyte_physiolog1.28875453
80MP0009785_altered_susceptibility_to1.27788291
81MP0000858_altered_metastatic_potential1.27694536
82MP0003329_amyloid_beta_deposits1.26414280
83MP0009384_cardiac_valve_regurgitation1.25816581
84MP0003786_premature_aging1.24572007
85MP0009053_abnormal_anal_canal1.23940536
86MP0000689_abnormal_spleen_morphology1.23212628
87MP0001986_abnormal_taste_sensitivity1.22717775
88MP0002429_abnormal_blood_cell1.22079215
89MP0002933_joint_inflammation1.22032320
90MP0002638_abnormal_pupillary_reflex1.21677443
91MP0001216_abnormal_epidermal_layer1.21474198
92MP0004381_abnormal_hair_follicle1.18927650
93MP0001340_abnormal_eyelid_morphology1.17291569
94MP0001853_heart_inflammation1.16793431
95MP0005023_abnormal_wound_healing1.15592297
96MP0009379_abnormal_foot_pigmentation1.13600989
97MP0002060_abnormal_skin_morphology1.11816782
98MP0003075_altered_response_to1.11475144
99MP0008877_abnormal_DNA_methylation1.09158202
100MP0008995_early_reproductive_senescence1.08212997
101MP0005025_abnormal_response_to1.06522153
102MP0000026_abnormal_inner_ear1.05061355
103MP0005388_respiratory_system_phenotype1.04919398
104MP0002133_abnormal_respiratory_system1.04919398
105MP0005171_absent_coat_pigmentation1.03398868
106MP0002019_abnormal_tumor_incidence1.02324657
107MP0003111_abnormal_nucleus_morphology1.01056853
108MP0000778_abnormal_nervous_system1.00156910
109MP0009745_abnormal_behavioral_response0.99979355
110MP0001533_abnormal_skeleton_physiology0.98742925
111MP0002089_abnormal_postnatal_growth/wei0.98384487
112MP0001905_abnormal_dopamine_level0.97763240
113MP0002970_abnormal_white_adipose0.97369787
114MP0005257_abnormal_intraocular_pressure0.97248896
115MP0000350_abnormal_cell_proliferation0.96982214
116MP0005075_abnormal_melanosome_morpholog0.96751948
117MP0001845_abnormal_inflammatory_respons0.96098320
118MP0008961_abnormal_basal_metabolism0.95408931
119MP0001346_abnormal_lacrimal_gland0.94646051
120MP0000613_abnormal_salivary_gland0.94639450
121MP0005076_abnormal_cell_differentiation0.93836938
122MP0003950_abnormal_plasma_membrane0.93038323
123MP0005501_abnormal_skin_physiology0.92193396
124MP0006072_abnormal_retinal_apoptosis0.91885766
125MP0001191_abnormal_skin_condition0.91638451
126MP0002419_abnormal_innate_immunity0.91415927
127MP0001879_abnormal_lymphatic_vessel0.90742490
128MP0010030_abnormal_orbit_morphology0.90346929
129MP0002572_abnormal_emotion/affect_behav0.90238839
130MP0003436_decreased_susceptibility_to0.89248692
131MP0002098_abnormal_vibrissa_morphology0.86694136
132MP0002796_impaired_skin_barrier0.86666403
133MP0002210_abnormal_sex_determination0.86037744
134MP0005464_abnormal_platelet_physiology0.84042231
135MP0010368_abnormal_lymphatic_system0.84038240
136MP0001485_abnormal_pinna_reflex0.83135914
137MP0002064_seizures0.82810988
138MP0002148_abnormal_hypersensitivity_rea0.81915607
139MP0003755_abnormal_palate_morphology0.81281783
140MP0000383_abnormal_hair_follicle0.80792861
141MP0000653_abnormal_sex_gland0.79523753
142MP0005535_abnormal_body_temperature0.79448415
143MP0005164_abnormal_response_to0.79324235
144MP0004147_increased_porphyrin_level0.78846448
145MP0001764_abnormal_homeostasis0.78752232
146MP0005390_skeleton_phenotype0.78492585
147MP0009780_abnormal_chondrocyte_physiolo0.78362013
148MP0001919_abnormal_reproductive_system0.77898658
149MP0005334_abnormal_fat_pad0.77582480
150MP0009931_abnormal_skin_appearance0.77179249
151MP0009672_abnormal_birth_weight0.77104278
152MP0005310_abnormal_salivary_gland0.77035115
153MP0001243_abnormal_dermal_layer0.76858812
154MP0001145_abnormal_male_reproductive0.76348272
155MP0000631_abnormal_neuroendocrine_gland0.75777559
156MP0003698_abnormal_male_reproductive0.74583544
157MP0003959_abnormal_lean_body0.74379266
158MP0000313_abnormal_cell_death0.73932841
159MP0000049_abnormal_middle_ear0.71741659
160MP0005448_abnormal_energy_balance0.71706314
161MP0000249_abnormal_blood_vessel0.71637292
162MP0001529_abnormal_vocalization0.71420279
163MP0005452_abnormal_adipose_tissue0.70764347
164MP0001270_distended_abdomen0.70325023
165MP0005503_abnormal_tendon_morphology0.69084187
166MP0000367_abnormal_coat/_hair0.68995989
167MP0005165_increased_susceptibility_to0.68706349
168MP0005584_abnormal_enzyme/coenzyme_acti0.64460449
169MP0002160_abnormal_reproductive_system0.63746308
170MP0000647_abnormal_sebaceous_gland0.63642963
171MP0001784_abnormal_fluid_regulation0.63104655
172MP0002067_abnormal_sensory_capabilities0.62978010
173MP0006138_congestive_heart_failure0.61325173
174MP0001440_abnormal_grooming_behavior0.60009901
175MP0000955_abnormal_spinal_cord0.59800328
176MP0000534_abnormal_ureter_morphology0.57688622
177MP0004233_abnormal_muscle_weight0.57358649

Predicted human phenotypes

RankGene SetZ-score
1Spinal rigidity (HP:0003306)5.20613660
2Split foot (HP:0001839)4.68819774
3Nasal polyposis (HP:0100582)4.57548174
4Aplastic anemia (HP:0001915)4.39851659
5Chronic bronchitis (HP:0004469)4.36254835
6Abnormality of the nasal mucosa (HP:0000433)4.15060396
7Nasal speech (HP:0001611)3.92889555
8Muscular dystrophy (HP:0003560)3.92447132
9Knee flexion contracture (HP:0006380)3.83414694
10Bronchitis (HP:0012387)3.83160422
11Generalized amyotrophy (HP:0003700)3.70374075
12Difficulty climbing stairs (HP:0003551)3.59780038
13Milia (HP:0001056)3.53900634
14Recurrent bronchitis (HP:0002837)3.47764146
15Muscle fiber splitting (HP:0003555)3.46979401
16Large for gestational age (HP:0001520)3.43057708
17IgM deficiency (HP:0002850)3.42665234
18Stomach cancer (HP:0012126)3.39866599
19Abnormality of cells of the erythroid lineage (HP:0012130)3.34035316
20Abnormal number of erythroid precursors (HP:0012131)3.33345563
21EMG: myopathic abnormalities (HP:0003458)3.31041977
22Chronic otitis media (HP:0000389)3.30848825
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.21504884
24Rhinitis (HP:0012384)3.16461141
25Bronchiectasis (HP:0002110)3.09263272
26Elevated erythrocyte sedimentation rate (HP:0003565)3.06086936
27Shoulder girdle muscle weakness (HP:0003547)3.03462539
28Recurrent corneal erosions (HP:0000495)2.90693278
29Supernumerary ribs (HP:0005815)2.89062245
30Myositis (HP:0100614)2.86091624
31Prostate neoplasm (HP:0100787)2.83363291
32Esophageal atresia (HP:0002032)2.82782352
33Neonatal short-limb short stature (HP:0008921)2.82379194
34Rapidly progressive (HP:0003678)2.82170555
35Ulnar claw (HP:0001178)2.78633222
36T lymphocytopenia (HP:0005403)2.76585245
37Abnormality of nail color (HP:0100643)2.75996199
38Abnormal mitochondria in muscle tissue (HP:0008316)2.74153256
39Onycholysis (HP:0001806)2.71420921
40Acute necrotizing encephalopathy (HP:0006965)2.71040055
41Abnormality of T cells (HP:0002843)2.71000917
42Pelvic girdle muscle weakness (HP:0003749)2.64311109
43Abnormality of T cell number (HP:0011839)2.58055838
44Lip pit (HP:0100267)2.57541211
45Sex reversal (HP:0012245)2.56381400
46Abnormal sex determination (HP:0012244)2.56381400
47Oligodactyly (HP:0012165)2.52476456
48Bronchomalacia (HP:0002780)2.48375227
49Pustule (HP:0200039)2.47645330
50Bone cyst (HP:0012062)2.46729238
51Inflammation of the large intestine (HP:0002037)2.46630478
52Absent/shortened dynein arms (HP:0200106)2.45594452
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.45594452
54Supernumerary bones of the axial skeleton (HP:0009144)2.45480851
55Missing ribs (HP:0000921)2.45377392
56Abnormality of T cell physiology (HP:0011840)2.41502065
57Abnormal respiratory motile cilium physiology (HP:0012261)2.41470810
58Petechiae (HP:0000967)2.39247077
59Oligodactyly (hands) (HP:0001180)2.38797992
60Gastrointestinal inflammation (HP:0004386)2.37657002
61Interstitial pulmonary disease (HP:0006530)2.37640911
62Palmoplantar hyperkeratosis (HP:0000972)2.35863022
63Abnormality of the hip-girdle musculature (HP:0001445)2.32886329
64Abnormality of the musculature of the pelvis (HP:0001469)2.32886329
65Abnormal respiratory epithelium morphology (HP:0012253)2.32727697
66Abnormal respiratory motile cilium morphology (HP:0005938)2.32727697
67Orchitis (HP:0100796)2.31105645
68Depressed nasal tip (HP:0000437)2.28921160
69Reticulocytopenia (HP:0001896)2.28507264
70Infertility (HP:0000789)2.27575093
71Thrombocytosis (HP:0001894)2.26468586
72Recurrent fungal infections (HP:0002841)2.25659955
7311 pairs of ribs (HP:0000878)2.24029155
74Abnormal spermatogenesis (HP:0008669)2.23937164
75Distal lower limb muscle weakness (HP:0009053)2.22625285
76Alopecia of scalp (HP:0002293)2.21464614
77Retrobulbar optic neuritis (HP:0100654)2.21294959
78Optic neuritis (HP:0100653)2.21294959
79Intellectual disability, profound (HP:0002187)2.20486040
80Abnormality of eosinophils (HP:0001879)2.19694129
81Severe combined immunodeficiency (HP:0004430)2.18657081
82Increased IgE level (HP:0003212)2.18311860
83True hermaphroditism (HP:0010459)2.16341142
84Type I transferrin isoform profile (HP:0003642)2.16161727
85Pallor (HP:0000980)2.15539385
86Abnormality of the fingertips (HP:0001211)2.12960398
87Autoimmune hemolytic anemia (HP:0001890)2.12119118
88Hypotrichosis (HP:0001006)2.10650937
89Palmar hyperkeratosis (HP:0010765)2.10619535
90Patchy hypopigmentation of hair (HP:0011365)2.09230042
91Cheilitis (HP:0100825)2.08925667
92Abnormality of B cell number (HP:0010975)2.08816387
93B lymphocytopenia (HP:0010976)2.08816387
94Colitis (HP:0002583)2.07977611
95Selective tooth agenesis (HP:0001592)2.07545312
96Progressive macrocephaly (HP:0004481)2.07425185
97Poor suck (HP:0002033)2.07373229
98Type II lissencephaly (HP:0007260)2.05995282
99Glucose intolerance (HP:0000833)2.04233220
100Segmental peripheral demyelination/remyelination (HP:0003481)2.02483338
101Entropion (HP:0000621)2.02359593
102Muscle fiber atrophy (HP:0100295)2.02263873
103Stenosis of the external auditory canal (HP:0000402)2.01610381
104Abnormal hemoglobin (HP:0011902)2.01447132
105Lymphoma (HP:0002665)2.01345678
106Plantar hyperkeratosis (HP:0007556)2.00451902
107Median cleft lip (HP:0000161)2.00253834
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.00004215
109Axonal loss (HP:0003447)11.7393576
110Diaphragmatic weakness (HP:0009113)11.3657909
111Acute myeloid leukemia (HP:0004808)1.99017027
112Cerebral edema (HP:0002181)1.98402070
113Eczematoid dermatitis (HP:0000976)1.96924655
114Thin ribs (HP:0000883)1.96580809
115Easy fatigability (HP:0003388)1.95196484
116Eosinophilia (HP:0001880)1.94883289
117Heterochromia iridis (HP:0001100)1.93126820
118Macrocytic anemia (HP:0001972)1.91783541
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.89197972
120Anterior segment dysgenesis (HP:0007700)1.88879709
121Granulocytopenia (HP:0001913)1.88873949
122Rib fusion (HP:0000902)1.88192917
123Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.88170860
124Fragile nails (HP:0001808)1.87460409
125Congenital, generalized hypertrichosis (HP:0004540)1.87376815
126Abnormal blistering of the skin (HP:0008066)1.87281603
127Degeneration of anterior horn cells (HP:0002398)1.87254969
128Abnormality of the anterior horn cell (HP:0006802)1.87254969
129Chronic sinusitis (HP:0011109)1.85685744
130Combined immunodeficiency (HP:0005387)1.84745666
131Hemivertebrae (HP:0002937)1.84679640
132Concave nail (HP:0001598)1.83619600
133Choroideremia (HP:0001139)1.83283433
134Parakeratosis (HP:0001036)1.83163769
135Alacrima (HP:0000522)1.82162516
136Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80776802
137Severe muscular hypotonia (HP:0006829)1.79799930
138IgG deficiency (HP:0004315)1.79427726
139Abnormality of the distal phalanges of the toes (HP:0010182)1.78776753
140Progressive sensorineural hearing impairment (HP:0000408)1.78103032
141Sparse eyelashes (HP:0000653)1.77980106
142Acute hepatic failure (HP:0006554)1.77718810
143Type 2 muscle fiber atrophy (HP:0003554)1.77444815
144Leukocytosis (HP:0001974)1.76340629
145Vertebral hypoplasia (HP:0008417)1.76182733
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76182733
147Growth hormone excess (HP:0000845)1.76098965
148Abnormality of binocular vision (HP:0011514)1.76078164
149Diplopia (HP:0000651)1.76078164
150Limb dystonia (HP:0002451)1.75611893
151Thyroiditis (HP:0100646)1.73908769
152Microretrognathia (HP:0000308)1.71980829
153Panhypogammaglobulinemia (HP:0003139)1.71594709
154Chronic diarrhea (HP:0002028)1.70806521
155Trismus (HP:0000211)1.70591428
156Anhidrosis (HP:0000970)1.69596912
157Septo-optic dysplasia (HP:0100842)1.69179708
158Sparse scalp hair (HP:0002209)1.68905857
159Prolonged bleeding time (HP:0003010)1.68788906
160Persistence of primary teeth (HP:0006335)1.68715832
161Hemiparesis (HP:0001269)1.68607237
162Rimmed vacuoles (HP:0003805)1.68087159
163Pancytopenia (HP:0001876)1.67816748
164Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67452883
165Broad face (HP:0000283)1.67149699
166Lymphopenia (HP:0001888)1.67053638
167Abnormal glycosylation (HP:0012345)1.66554336
168Weak cry (HP:0001612)1.65715250
169Prominent supraorbital ridges (HP:0000336)1.65405718
170Abnormality of the diencephalon (HP:0010662)1.64596557
171Tongue fasciculations (HP:0001308)1.64076676
172Acute encephalopathy (HP:0006846)1.63991728
173Abnormality of the 4th metacarpal (HP:0010012)1.63950233
174Spastic paraparesis (HP:0002313)1.62578218
175Progressive microcephaly (HP:0000253)1.61304736
176Gastrointestinal atresia (HP:0002589)1.61010430
177Abnormal ciliary motility (HP:0012262)1.60975505
178Down-sloping shoulders (HP:0200021)1.58858024
179Arthropathy (HP:0003040)1.58841083
180Epidermoid cyst (HP:0200040)1.57008192
181Nail dystrophy (HP:0008404)1.56089490
182Cerebellar dysplasia (HP:0007033)1.55805429
183Trigonocephaly (HP:0000243)1.55638688
184Limb-girdle muscle weakness (HP:0003325)1.54347561
185Thick nail (HP:0001805)1.52250983
186Leukodystrophy (HP:0002415)1.51380083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK66.57550090
2MAPK155.66349192
3BCKDK3.19388611
4VRK12.66701546
5NLK2.41868053
6MAP4K12.33849194
7MAP2K22.33261438
8STK102.21901970
9EPHA32.09309039
10TGFBR22.05705103
11TXK2.01843176
12RPS6KB21.66666516
13EPHA21.65358290
14TBK11.65019707
15EPHB11.64966375
16IKBKE1.64755751
17BMPR1B1.61942356
18MAP3K31.60405684
19RPS6KA41.58907542
20TGFBR11.54173588
21MST41.48693683
22PIM21.48310797
23ITK1.48217548
24WEE11.43594648
25FGFR41.38977973
26MAP3K141.38542710
27ARAF1.36036891
28IKBKB1.33347815
29DYRK31.31425289
30TESK11.30502871
31HIPK21.30092354
32RPS6KA51.26020790
33BTK1.22078783
34MAPKAPK31.20705338
35WNK41.20597864
36TESK21.19270489
37CDK31.19056789
38IRAK11.17814241
39ZAP701.15898316
40SIK11.15389028
41TEC1.14040713
42TAOK31.09284974
43CDK81.06308529
44PRPF4B1.06154535
45CHUK1.05739277
46KDR1.03265072
47JAK31.01753004
48MAPKAPK20.99885612
49CDK90.94757814
50STK390.94738272
51MAP2K30.93832654
52PIM10.93736205
53BUB10.93081726
54PASK0.92982078
55TYRO30.91631561
56ACVR1B0.90139489
57SIK30.89647348
58PDK20.84480836
59IRAK40.84384872
60IRAK30.82589544
61EEF2K0.81981871
62BRSK20.80246866
63TYK20.79637214
64EPHB20.75660946
65DMPK0.74159670
66CAMKK20.72652588
67LATS20.70753386
68CDK120.69781623
69TRIB30.68255122
70MAP3K120.63331029
71PDK40.62235470
72PDK30.62235470
73TAOK20.60960214
74NEK20.60679320
75CAMKK10.60571389
76ERN10.59007020
77RAF10.57453715
78JAK10.56977638
79RPS6KA60.56502577
80FGFR30.55492082
81MST1R0.55464155
82MUSK0.54845107
83MTOR0.52672382
84UHMK10.52409629
85MAPK70.52117493
86MAP3K10.51948409
87MAP3K100.51741116
88NTRK20.51511540
89MAP3K130.50570712
90CDK70.49469690
91STK30.49044331
92NME20.48351132
93RPS6KC10.45821092
94RPS6KL10.45821092
95LRRK20.44926441
96LCK0.44836395
97PDGFRB0.44614815
98CAMK1D0.44582145
99BRD40.43553824
100TLK10.43201179
101SIK20.40765855
102PAK20.40684709
103MAP3K90.40100687
104GSK3A0.39954668
105MAP3K110.39843436
106RPS6KA10.39667147
107CLK10.39596807
108MAPK40.39431281
109MAP3K20.39189207
110KSR20.37205603
111MET0.37119518
112PNCK0.37114057
113KIT0.36180369
114JAK20.35982765
115PRKD30.35482426
116MAP3K50.35287860
117ATR0.35280840
118CASK0.35041858
119DYRK1B0.34965565
120CDK40.33854275
121EIF2AK20.33209297
122TIE10.32982978
123PLK30.31767894
124MARK20.31367821
125PRKD20.31353830
126INSRR0.31070868
127PRKD10.30379877
128MAP2K60.30360142
129CDK60.30151650
130MAPK30.29890518
131GRK70.29564506
132MARK30.29187053
133AURKA0.28970522
134MOS0.28615927
135LMTK20.27640408
136KSR10.25845004
137PRKCG0.25709669
138PKN10.24694497
139ABL20.24202222
140IRAK20.22390237
141ERBB40.22307690
142PTK2B0.21681906
143PRKCD0.21470041
144NME10.19426300
145MAPK100.17871673
146LIMK10.16943373
147PRKCI0.15923287
148MAPK120.14642046
149NEK60.14491140
150BRSK10.12552676
151GRK60.12539987
152PTK20.12053687
153ADRBK10.09939157

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.70368141
2Antigen processing and presentation_Homo sapiens_hsa046123.28743201
3Ribosome_Homo sapiens_hsa030102.20183570
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18535680
5DNA replication_Homo sapiens_hsa030302.17624659
6Primary immunodeficiency_Homo sapiens_hsa053402.07176985
7Protein export_Homo sapiens_hsa030601.95707220
8Measles_Homo sapiens_hsa051621.95443422
9Spliceosome_Homo sapiens_hsa030401.93843287
10Legionellosis_Homo sapiens_hsa051341.77489819
11Sulfur relay system_Homo sapiens_hsa041221.69456307
12T cell receptor signaling pathway_Homo sapiens_hsa046601.64670751
13Osteoclast differentiation_Homo sapiens_hsa043801.64106699
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.63910145
15Toxoplasmosis_Homo sapiens_hsa051451.62427390
16Mismatch repair_Homo sapiens_hsa034301.62330903
17* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60861712
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56458201
19Herpes simplex infection_Homo sapiens_hsa051681.55621188
20Non-homologous end-joining_Homo sapiens_hsa034501.51503299
21Cell cycle_Homo sapiens_hsa041101.51093599
22RNA degradation_Homo sapiens_hsa030181.48862978
23Epstein-Barr virus infection_Homo sapiens_hsa051691.45623487
24B cell receptor signaling pathway_Homo sapiens_hsa046621.43191231
25Circadian rhythm_Homo sapiens_hsa047101.42869058
26Leishmaniasis_Homo sapiens_hsa051401.38477109
27TNF signaling pathway_Homo sapiens_hsa046681.38288202
28Cocaine addiction_Homo sapiens_hsa050301.37507939
29RNA polymerase_Homo sapiens_hsa030201.34316984
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32469873
31HTLV-I infection_Homo sapiens_hsa051661.31103552
32Hematopoietic cell lineage_Homo sapiens_hsa046401.30982955
33Basal transcription factors_Homo sapiens_hsa030221.30034914
34Base excision repair_Homo sapiens_hsa034101.29064428
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.27625971
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.26295468
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.25909914
38p53 signaling pathway_Homo sapiens_hsa041151.25003089
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24240175
40Amphetamine addiction_Homo sapiens_hsa050311.23505688
41Hepatitis B_Homo sapiens_hsa051611.21653507
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20319402
43* Influenza A_Homo sapiens_hsa051641.19653586
44Apoptosis_Homo sapiens_hsa042101.17150229
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13984318
46RNA transport_Homo sapiens_hsa030131.13058415
47Viral carcinogenesis_Homo sapiens_hsa052031.10939741
48Pyrimidine metabolism_Homo sapiens_hsa002401.10114208
49Acute myeloid leukemia_Homo sapiens_hsa052211.09074601
50Homologous recombination_Homo sapiens_hsa034401.04373706
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04006255
52Shigellosis_Homo sapiens_hsa051311.00804343
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97509417
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96801704
55Small cell lung cancer_Homo sapiens_hsa052220.95936860
56Colorectal cancer_Homo sapiens_hsa052100.94250893
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94055253
58Fanconi anemia pathway_Homo sapiens_hsa034600.94014484
59ErbB signaling pathway_Homo sapiens_hsa040120.92232997
60Thyroid cancer_Homo sapiens_hsa052160.91757247
61Parkinsons disease_Homo sapiens_hsa050120.91067489
62Regulation of autophagy_Homo sapiens_hsa041400.90948291
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88707105
64Nicotine addiction_Homo sapiens_hsa050330.87178240
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86734582
66Proteasome_Homo sapiens_hsa030500.85820648
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83545915
68Prolactin signaling pathway_Homo sapiens_hsa049170.79911530
69Prostate cancer_Homo sapiens_hsa052150.78382366
70Nucleotide excision repair_Homo sapiens_hsa034200.77870571
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77560417
72GABAergic synapse_Homo sapiens_hsa047270.77220143
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.77006788
74Hedgehog signaling pathway_Homo sapiens_hsa043400.75521354
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73825336
76Salmonella infection_Homo sapiens_hsa051320.72885889
77Prion diseases_Homo sapiens_hsa050200.71417390
78Nitrogen metabolism_Homo sapiens_hsa009100.70982942
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70254810
80Chronic myeloid leukemia_Homo sapiens_hsa052200.68592860
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68368998
82Pertussis_Homo sapiens_hsa051330.67923373
83Malaria_Homo sapiens_hsa051440.67246862
84Notch signaling pathway_Homo sapiens_hsa043300.67031438
85Linoleic acid metabolism_Homo sapiens_hsa005910.65015934
86MAPK signaling pathway_Homo sapiens_hsa040100.65000052
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64414388
88Estrogen signaling pathway_Homo sapiens_hsa049150.64369594
89Pancreatic cancer_Homo sapiens_hsa052120.64258755
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64214358
91Huntingtons disease_Homo sapiens_hsa050160.63640106
92Oxidative phosphorylation_Homo sapiens_hsa001900.62430633
93mRNA surveillance pathway_Homo sapiens_hsa030150.62405825
94Hepatitis C_Homo sapiens_hsa051600.61638841
95FoxO signaling pathway_Homo sapiens_hsa040680.61458279
96Folate biosynthesis_Homo sapiens_hsa007900.59842540
97Systemic lupus erythematosus_Homo sapiens_hsa053220.59810623
98Sulfur metabolism_Homo sapiens_hsa009200.59794035
99Morphine addiction_Homo sapiens_hsa050320.59424073
100Hippo signaling pathway_Homo sapiens_hsa043900.59144229
101Renal cell carcinoma_Homo sapiens_hsa052110.58681738
102Pathways in cancer_Homo sapiens_hsa052000.58268204
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56214966
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55978696
105Purine metabolism_Homo sapiens_hsa002300.55321243
106Graft-versus-host disease_Homo sapiens_hsa053320.53752496
107Other glycan degradation_Homo sapiens_hsa005110.53662374
108TGF-beta signaling pathway_Homo sapiens_hsa043500.53611577
109Taste transduction_Homo sapiens_hsa047420.52762923
110Steroid biosynthesis_Homo sapiens_hsa001000.52528975
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50714393
112N-Glycan biosynthesis_Homo sapiens_hsa005100.50702959
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49709822
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49520712
115Endocytosis_Homo sapiens_hsa041440.48379448
116Adherens junction_Homo sapiens_hsa045200.47574319
117Sphingolipid metabolism_Homo sapiens_hsa006000.47363856
118Glutathione metabolism_Homo sapiens_hsa004800.46919945
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45600023
120Arachidonic acid metabolism_Homo sapiens_hsa005900.45475566
121Wnt signaling pathway_Homo sapiens_hsa043100.43888563
122PPAR signaling pathway_Homo sapiens_hsa033200.43608202
123Basal cell carcinoma_Homo sapiens_hsa052170.43495570
124ECM-receptor interaction_Homo sapiens_hsa045120.43377282
125Vibrio cholerae infection_Homo sapiens_hsa051100.43107390
126VEGF signaling pathway_Homo sapiens_hsa043700.42957712
127Axon guidance_Homo sapiens_hsa043600.42955655
128Melanogenesis_Homo sapiens_hsa049160.42469180
129GnRH signaling pathway_Homo sapiens_hsa049120.41713957
130Ovarian steroidogenesis_Homo sapiens_hsa049130.41280214
131cAMP signaling pathway_Homo sapiens_hsa040240.40907568
132Platelet activation_Homo sapiens_hsa046110.40444784
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.39867469
134Choline metabolism in cancer_Homo sapiens_hsa052310.37651243
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36911660
136Circadian entrainment_Homo sapiens_hsa047130.36409080
137Alzheimers disease_Homo sapiens_hsa050100.35470165
138Cholinergic synapse_Homo sapiens_hsa047250.33658894
139Chemical carcinogenesis_Homo sapiens_hsa052040.33546542
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32954236
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32262426
142Rheumatoid arthritis_Homo sapiens_hsa053230.31110567
143Ras signaling pathway_Homo sapiens_hsa040140.30537889
144Collecting duct acid secretion_Homo sapiens_hsa049660.29498433
145Bile secretion_Homo sapiens_hsa049760.29331851
146Cardiac muscle contraction_Homo sapiens_hsa042600.26948614
147Dopaminergic synapse_Homo sapiens_hsa047280.23320147
148Glutamatergic synapse_Homo sapiens_hsa047240.21667431
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18171544
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13934702
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12207058
152Calcium signaling pathway_Homo sapiens_hsa040200.10883322
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10743219

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