DMTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.33541086
2oxygen transport (GO:0015671)6.22353600
3synaptic vesicle maturation (GO:0016188)6.05801477
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.84791466
5locomotory exploration behavior (GO:0035641)5.59112443
6synaptic vesicle exocytosis (GO:0016079)5.58138683
7vocalization behavior (GO:0071625)5.57214226
8gas transport (GO:0015669)5.53333922
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.49406618
10glutamate secretion (GO:0014047)5.46574693
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42968927
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.27263797
13regulation of glutamate receptor signaling pathway (GO:1900449)5.16678632
14regulation of synaptic vesicle exocytosis (GO:2000300)5.15599439
15protein localization to synapse (GO:0035418)5.00049739
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.86416231
17protoporphyrinogen IX metabolic process (GO:0046501)4.78175685
18neuronal action potential propagation (GO:0019227)4.76607265
19regulation of neuronal synaptic plasticity (GO:0048168)4.69468415
20regulation of synaptic vesicle transport (GO:1902803)4.62251430
21hemoglobin metabolic process (GO:0020027)4.62149859
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.59370630
23neuron cell-cell adhesion (GO:0007158)4.54304834
24exploration behavior (GO:0035640)4.52668247
25neurotransmitter secretion (GO:0007269)4.49286945
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.46755576
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.30473147
28synaptic transmission, glutamatergic (GO:0035249)4.30432024
29glutamate receptor signaling pathway (GO:0007215)4.30307364
30regulation of synapse structural plasticity (GO:0051823)4.26090876
31neuron-neuron synaptic transmission (GO:0007270)4.14185369
32neurotransmitter-gated ion channel clustering (GO:0072578)4.14171388
33cerebellar granule cell differentiation (GO:0021707)4.10796382
34regulation of ARF protein signal transduction (GO:0032012)4.01749544
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00563253
36positive regulation of membrane potential (GO:0045838)3.99955832
37dendritic spine morphogenesis (GO:0060997)3.95154363
38layer formation in cerebral cortex (GO:0021819)3.93874115
39long-term memory (GO:0007616)3.90726904
40proline transport (GO:0015824)3.88673891
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.84963641
42regulation of synaptic plasticity (GO:0048167)3.79817336
43regulation of postsynaptic membrane potential (GO:0060078)3.79246810
44regulation of dendritic spine morphogenesis (GO:0061001)3.73519928
45neurotransmitter transport (GO:0006836)3.71499797
46synaptic vesicle endocytosis (GO:0048488)3.69824690
47positive regulation of synapse maturation (GO:0090129)3.69625171
48protoporphyrinogen IX biosynthetic process (GO:0006782)3.68563105
49positive regulation of neurotransmitter secretion (GO:0001956)3.67462362
50gamma-aminobutyric acid transport (GO:0015812)3.66796970
51L-amino acid import (GO:0043092)3.66018834
52cellular potassium ion homeostasis (GO:0030007)3.62323238
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58481158
54positive regulation of neurotransmitter transport (GO:0051590)3.57773915
55neuromuscular process controlling balance (GO:0050885)3.57071261
56regulation of neurotransmitter secretion (GO:0046928)3.55488215
57transmission of nerve impulse (GO:0019226)3.54037061
58neuron recognition (GO:0008038)3.53843015
59long-term synaptic potentiation (GO:0060291)3.51922184
60neuromuscular process controlling posture (GO:0050884)3.51850807
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.51498280
62glycine transport (GO:0015816)3.50977249
63activation of protein kinase A activity (GO:0034199)3.50552999
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.44150679
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43712478
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43370931
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.42622430
68regulation of vesicle fusion (GO:0031338)3.42119059
69negative regulation of cell killing (GO:0031342)3.40820165
70negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40820165
71regulation of neurotransmitter levels (GO:0001505)3.40507161
72positive regulation of Rap GTPase activity (GO:0032854)3.37964081
73auditory behavior (GO:0031223)3.35321986
74cerebellar Purkinje cell differentiation (GO:0021702)3.35250696
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33369040
76postsynaptic membrane organization (GO:0001941)3.31340823
77porphyrin-containing compound biosynthetic process (GO:0006779)3.30309841
78sodium ion export (GO:0071436)3.30085115
79membrane depolarization (GO:0051899)3.29284188
80regulation of neurotransmitter transport (GO:0051588)3.28154248
81membrane depolarization during action potential (GO:0086010)3.28052424
82regulation of glutamate secretion (GO:0014048)3.25123602
83axonal fasciculation (GO:0007413)3.23349847
84prepulse inhibition (GO:0060134)3.22490183
85response to histamine (GO:0034776)3.21424629
86response to auditory stimulus (GO:0010996)3.20656205
87negative regulation of erythrocyte differentiation (GO:0045647)3.20397412
88positive regulation of dendritic spine development (GO:0060999)3.19574311
89behavioral fear response (GO:0001662)3.19203849
90behavioral defense response (GO:0002209)3.19203849
91regulation of dendritic spine development (GO:0060998)3.19060641
92negative regulation of dendrite morphogenesis (GO:0050774)3.16101050
93neuronal ion channel clustering (GO:0045161)3.15561075
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14861983
95membrane hyperpolarization (GO:0060081)3.14672316
96learning (GO:0007612)3.13418834
97regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13099140
98presynaptic membrane assembly (GO:0097105)3.11723861
99positive regulation of synaptic transmission (GO:0050806)3.11115181
100G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10826180
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10583615
102regulation of synaptic transmission (GO:0050804)3.09897058
103protein targeting to plasma membrane (GO:0072661)3.09465071
104synaptic transmission (GO:0007268)3.08911170
105signal complex assembly (GO:0007172)3.07959053
106positive regulation of dendritic spine morphogenesis (GO:0061003)3.07952133
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07407804
108neuromuscular process (GO:0050905)3.05844606
109behavioral response to cocaine (GO:0048148)3.05756912
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05134548
111dendritic spine organization (GO:0097061)3.04033705
112cell migration in hindbrain (GO:0021535)3.02813823
113erythrocyte maturation (GO:0043249)3.01659978
114fear response (GO:0042596)3.00319062
115amino acid import (GO:0043090)2.99973000
116vesicle transport along microtubule (GO:0047496)2.99625149
117cytoskeletal anchoring at plasma membrane (GO:0007016)2.98305301
118regulation of female receptivity (GO:0045924)2.98244986
119negative regulation of amino acid transport (GO:0051956)2.97708739
120regulation of Rap GTPase activity (GO:0032317)2.97133250
121regulation of amyloid precursor protein catabolic process (GO:1902991)2.85405622
122regulation of voltage-gated calcium channel activity (GO:1901385)2.83876054
123heme biosynthetic process (GO:0006783)2.82446924
124neutrophil activation involved in immune response (GO:0002283)2.81419813
125response to methylmercury (GO:0051597)2.77857059
126tetrapyrrole biosynthetic process (GO:0033014)2.74703044
127regulation of exocytosis (GO:0017157)2.72226947
128potassium ion homeostasis (GO:0055075)2.72038794
129regulation of synapse maturation (GO:0090128)2.69602378
130regulation of regulated secretory pathway (GO:1903305)2.67580863
131regulation of beta-amyloid formation (GO:1902003)2.66518464
132porphyrin-containing compound metabolic process (GO:0006778)2.64950040
133cell differentiation in hindbrain (GO:0021533)2.63807938
134potassium ion import (GO:0010107)2.61848724
135modulation by virus of host process (GO:0019054)2.53864223
136cell communication by electrical coupling (GO:0010644)2.51403771
137response to insecticide (GO:0017085)2.50604836
138vesicle docking involved in exocytosis (GO:0006904)2.50041842
139regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49685900
140neurotransmitter uptake (GO:0001504)2.48448148
141actin filament polymerization (GO:0030041)2.47871075
142regulation of response to osmotic stress (GO:0047484)2.46402869
143mitochondrion degradation (GO:0000422)2.42032467
144regulation of ARF GTPase activity (GO:0032312)2.39243513
145positive regulation of exocytosis (GO:0045921)2.38895633
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.38694696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.29446336
2GBX2_23144817_ChIP-Seq_PC3_Human3.60521696
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.50644134
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.31027499
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.21339312
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09539778
7GATA1_19941826_ChIP-Seq_K562_Human3.05067620
8REST_21632747_ChIP-Seq_MESCs_Mouse3.01356247
9RARB_27405468_Chip-Seq_BRAIN_Mouse3.00953858
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79533984
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79533984
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79515931
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66425853
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61597040
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59349230
16GATA1_22025678_ChIP-Seq_K562_Human2.56124475
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.55167597
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54699100
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54314298
20DROSHA_22980978_ChIP-Seq_HELA_Human2.52327590
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.49701846
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.43480466
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36833226
24KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35907197
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.34459075
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.28815369
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28264509
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21213132
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.20403757
30SCL_19346495_ChIP-Seq_HPC-7_Human2.19609926
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16788371
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11426511
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10162772
34* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.08706562
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06373638
36KDM2B_26808549_Chip-Seq_DND41_Human2.00394239
37LXR_22292898_ChIP-Seq_THP-1_Human1.99599418
38GATA2_19941826_ChIP-Seq_K562_Human1.95907974
39TCF7_22412390_ChIP-Seq_EML_Mouse1.93935206
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.92033007
41AR_21572438_ChIP-Seq_LNCaP_Human1.77464930
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71584802
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71032190
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69360380
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69350977
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67187481
47SPI1_23127762_ChIP-Seq_K562_Human1.64959363
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60192671
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60092235
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56630679
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55965620
52TAF15_26573619_Chip-Seq_HEK293_Human1.54335287
53SMAD4_21799915_ChIP-Seq_A2780_Human1.53433821
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50176071
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44954965
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44564299
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.43066532
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42405838
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38265341
60SMC4_20622854_ChIP-Seq_HELA_Human1.37501420
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.36943680
62P68_20966046_ChIP-Seq_HELA_Human1.36279699
63VDR_21846776_ChIP-Seq_THP-1_Human1.36139094
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34610401
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.33693641
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31730808
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31264055
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30722905
69* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30545509
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30068846
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28483746
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28302710
73KDM2B_26808549_Chip-Seq_K562_Human1.28291809
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27836944
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27091041
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.25304639
77OCT4_19829295_ChIP-Seq_ESCs_Human1.25097872
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23917313
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21047528
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20704199
81P300_19829295_ChIP-Seq_ESCs_Human1.19950620
82VDR_24763502_ChIP-Seq_THP-1_Human1.19684251
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19318971
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19239223
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19004188
86AR_19668381_ChIP-Seq_PC3_Human1.18109654
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.18027154
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17266324
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15729993
90CREB1_26743006_Chip-Seq_LNCaP_Human1.15425918
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15177579
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14914844
93MAF_26560356_Chip-Seq_TH1_Human1.13965548
94ZNF274_21170338_ChIP-Seq_K562_Hela1.13625362
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.13481753
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13237517
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.13070638
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12876621
99STAT3_23295773_ChIP-Seq_U87_Human1.11904975
100* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11542988
101RUNX_20019798_ChIP-Seq_JUKART_Human1.11380801
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11100049
103AR_25329375_ChIP-Seq_VCAP_Human1.10134836
104UTX_26944678_Chip-Seq_JUKART_Human1.09488841
105BCOR_27268052_Chip-Seq_Bcells_Human1.09037203
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.07894372
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.07479868
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07404830
109ELF1_20517297_ChIP-Seq_JURKAT_Human1.07141034
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06384255
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05851187
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.05622297
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05293063
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05217618
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.04074917
116RNF2_27304074_Chip-Seq_NSC_Mouse1.04041627
117CTCF_27219007_Chip-Seq_Bcells_Human1.03976225
118EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03913295
119MYC_22102868_ChIP-Seq_BL_Human1.03387870
120BCL6_27268052_Chip-Seq_Bcells_Human1.02641129
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02296446
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01833768
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01247350
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00047813
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99954898
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99913951
127KLF4_19829295_ChIP-Seq_ESCs_Human0.99686492
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98466542
129TCF4_23295773_ChIP-Seq_U87_Human0.97924217
130DPY_21335234_ChIP-Seq_ESCs_Mouse0.97743519
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97732896
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97457084
133KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95997721
134RACK7_27058665_Chip-Seq_MCF-7_Human0.95986976
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95719051
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.94595701
137BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94446213
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.93817769
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.92648132
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91074796
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.90747494
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.89433171
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.88700383
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88272627
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87393702
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.87237490
147AHR_22903824_ChIP-Seq_MCF-7_Human0.86737827
148RUNX2_22187159_ChIP-Seq_PCA_Human0.85777116
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85524453
150IGF1R_20145208_ChIP-Seq_DFB_Human0.85465830
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.85297230
152VDR_22108803_ChIP-Seq_LS180_Human0.83122796
153ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82972772
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82803592
155VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81340805
156JUN_21703547_ChIP-Seq_K562_Human0.81078140
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80987394
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80319981
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77832694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.78499934
2MP0003880_abnormal_central_pattern5.08214570
3MP0003635_abnormal_synaptic_transmissio4.21595772
4MP0004270_analgesia3.73351245
5MP0009745_abnormal_behavioral_response3.52654549
6MP0001968_abnormal_touch/_nociception3.41709579
7MP0002063_abnormal_learning/memory/cond3.39980864
8MP0002822_catalepsy3.38093314
9MP0002064_seizures3.21868571
10MP0009046_muscle_twitch3.06628977
11MP0002572_abnormal_emotion/affect_behav2.81452581
12MP0002734_abnormal_mechanical_nocicepti2.75517878
13MP0002736_abnormal_nociception_after2.71946386
14MP0002735_abnormal_chemical_nociception2.65405145
15MP0002272_abnormal_nervous_system2.63058618
16MP0005423_abnormal_somatic_nervous2.62933521
17MP0001486_abnormal_startle_reflex2.53198845
18MP0003303_peritoneal_inflammation2.49368726
19MP0005083_abnormal_biliary_tract2.35578558
20MP0005464_abnormal_platelet_physiology2.34074331
21MP0001501_abnormal_sleep_pattern2.26928092
22MP0002733_abnormal_thermal_nociception2.24254907
23MP0003172_abnormal_lysosome_physiology2.17113527
24MP0001440_abnormal_grooming_behavior2.15686239
25MP0001970_abnormal_pain_threshold2.11330968
26MP0008260_abnormal_autophagy2.10139400
27MP0002067_abnormal_sensory_capabilities1.98505351
28MP0004858_abnormal_nervous_system1.86685322
29MP0004811_abnormal_neuron_physiology1.80404410
30MP0003724_increased_susceptibility_to1.79754605
31MP0003329_amyloid_beta_deposits1.79645312
32MP0006276_abnormal_autonomic_nervous1.78239740
33MP0008569_lethality_at_weaning1.72237403
34MP0005386_behavior/neurological_phenoty1.70887533
35MP0004924_abnormal_behavior1.70887533
36MP0003879_abnormal_hair_cell1.70802030
37MP0002557_abnormal_social/conspecific_i1.70482655
38MP0002184_abnormal_innervation1.69952575
39MP0005646_abnormal_pituitary_gland1.65670233
40MP0000778_abnormal_nervous_system1.62387907
41MP0003436_decreased_susceptibility_to1.60614149
42MP0004130_abnormal_muscle_cell1.60104314
43MP0009780_abnormal_chondrocyte_physiolo1.59260951
44MP0001529_abnormal_vocalization1.54614916
45MP0002909_abnormal_adrenal_gland1.52076919
46MP0000955_abnormal_spinal_cord1.51383609
47MP0001984_abnormal_olfaction1.47246538
48MP0003787_abnormal_imprinting1.45496116
49MP0002066_abnormal_motor_capabilities/c1.42737758
50MP0004510_myositis1.40054481
51MP0002882_abnormal_neuron_morphology1.38896968
52MP0005645_abnormal_hypothalamus_physiol1.38575197
53MP0004885_abnormal_endolymph1.35887381
54MP0003123_paternal_imprinting1.35401452
55MP0004142_abnormal_muscle_tone1.34512478
56MP0008872_abnormal_physiological_respon1.32389271
57MP0001905_abnormal_dopamine_level1.31579706
58MP0003633_abnormal_nervous_system1.31204892
59MP0003191_abnormal_cellular_cholesterol1.31159244
60MP0004147_increased_porphyrin_level1.28231570
61MP0003656_abnormal_erythrocyte_physiolo1.27583334
62MP0001188_hyperpigmentation1.21038391
63MP0003183_abnormal_peptide_metabolism1.19241214
64MP0001502_abnormal_circadian_rhythm1.14362589
65MP0003122_maternal_imprinting1.13946947
66MP0001545_abnormal_hematopoietic_system1.12680930
67MP0005397_hematopoietic_system_phenotyp1.12680930
68MP0003631_nervous_system_phenotype1.12552716
69MP0005377_hearing/vestibular/ear_phenot1.09651994
70MP0003878_abnormal_ear_physiology1.09651994
71MP0002152_abnormal_brain_morphology1.06017487
72MP0003866_abnormal_defecation1.04439325
73MP0003045_fibrosis1.04091535
74MP0002132_abnormal_respiratory_system1.01815893
75MP0002419_abnormal_innate_immunity1.00097547
76MP0005025_abnormal_response_to0.97558790
77MP0002229_neurodegeneration0.97518642
78MP0003075_altered_response_to0.95799971
79MP0008874_decreased_physiological_sensi0.95403166
80MP0008004_abnormal_stomach_pH0.94665280
81MP0003283_abnormal_digestive_organ0.94170099
82MP0002069_abnormal_eating/drinking_beha0.94119708
83MP0001986_abnormal_taste_sensitivity0.92187149
84MP0005535_abnormal_body_temperature0.90711727
85MP0000751_myopathy0.87469121
86MP0004742_abnormal_vestibular_system0.86324827
87MP0005000_abnormal_immune_tolerance0.84777406
88MP0005499_abnormal_olfactory_system0.84373302
89MP0005394_taste/olfaction_phenotype0.84373302
90MP0009278_abnormal_bone_marrow0.83360693
91MP0001963_abnormal_hearing_physiology0.82845463
92MP0002398_abnormal_bone_marrow0.81476412
93MP0004085_abnormal_heartbeat0.80715377
94MP0005166_decreased_susceptibility_to0.79639950
95MP0003300_gastrointestinal_ulcer0.78205923
96MP0001177_atelectasis0.77492964
97MP0001851_eye_inflammation0.76271641
98MP0004043_abnormal_pH_regulation0.76267407
99MP0004145_abnormal_muscle_electrophysio0.75972827
100MP0008961_abnormal_basal_metabolism0.75593424
101MP0005551_abnormal_eye_electrophysiolog0.74687896
102MP0010386_abnormal_urinary_bladder0.74497940
103MP0002420_abnormal_adaptive_immunity0.74249064
104MP0002752_abnormal_somatic_nervous0.73756035
105MP0001819_abnormal_immune_cell0.71874207
106MP0005451_abnormal_body_composition0.71843036
107MP0002332_abnormal_exercise_endurance0.71545582
108MP0003632_abnormal_nervous_system0.71147708
109MP0003634_abnormal_glial_cell0.70627625
110MP0000604_amyloidosis0.69370791
111MP0000685_abnormal_immune_system0.68651697
112MP0005636_abnormal_mineral_homeostasis0.68221132
113MP0002876_abnormal_thyroid_physiology0.67103198
114MP0001485_abnormal_pinna_reflex0.66998554
115MP0004947_skin_inflammation0.66619050
116MP0005409_darkened_coat_color0.66349800
117MP0000013_abnormal_adipose_tissue0.65679843
118MP0005387_immune_system_phenotype0.65646507
119MP0001790_abnormal_immune_system0.65646507
120MP0000631_abnormal_neuroendocrine_gland0.65590281
121MP0005310_abnormal_salivary_gland0.65299223
122MP0003690_abnormal_glial_cell0.64855712
123MP0000920_abnormal_myelination0.64683955
124MP0000015_abnormal_ear_pigmentation0.63701459
125MP0006082_CNS_inflammation0.61703903
126MP0004215_abnormal_myocardial_fiber0.60710042
127MP0001664_abnormal_digestion0.60585467
128MP0005167_abnormal_blood-brain_barrier0.59961896
129MP0004484_altered_response_of0.59539515
130MP0001765_abnormal_ion_homeostasis0.55724876
131MP0002837_dystrophic_cardiac_calcinosis0.55704130
132MP0003137_abnormal_impulse_conducting0.55145494
133MP0010769_abnormal_survival0.54190310
134MP0002653_abnormal_ependyma_morphology0.53235568
135MP0003861_abnormal_nervous_system0.52985977
136MP0001943_abnormal_respiration0.51738996
137MP0010768_mortality/aging0.51417174
138MP0010770_preweaning_lethality0.51344753
139MP0002082_postnatal_lethality0.51344753
140MP0003956_abnormal_body_size0.50811103
141MP0002090_abnormal_vision0.48851299

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.00460757
2Hypochromic microcytic anemia (HP:0004840)7.65241748
3Myokymia (HP:0002411)7.55336155
4Focal seizures (HP:0007359)6.08238722
5Visual hallucinations (HP:0002367)5.28252149
6Epileptic encephalopathy (HP:0200134)5.05172284
7Febrile seizures (HP:0002373)4.90870007
8Atonic seizures (HP:0010819)4.82613654
9Hypochromic anemia (HP:0001931)4.75859829
10Absence seizures (HP:0002121)4.23025895
11Prolonged bleeding time (HP:0003010)4.17299124
12Generalized tonic-clonic seizures (HP:0002069)4.14933808
13Microcytic anemia (HP:0001935)4.12209065
14Dialeptic seizures (HP:0011146)4.00446992
15Progressive cerebellar ataxia (HP:0002073)3.96318311
16Action tremor (HP:0002345)3.73645305
17Ankle clonus (HP:0011448)3.53488427
18Supranuclear gaze palsy (HP:0000605)3.47197873
19Depression (HP:0000716)3.45873145
20Impaired vibration sensation in the lower limbs (HP:0002166)3.43789469
21Abnormal hemoglobin (HP:0011902)3.41384909
22Broad-based gait (HP:0002136)3.41080805
23Poor eye contact (HP:0000817)3.40051966
24Cholelithiasis (HP:0001081)3.30197042
25Anxiety (HP:0000739)3.28083364
26Gaze-evoked nystagmus (HP:0000640)3.27366747
27Abnormality of the lower motor neuron (HP:0002366)3.22887305
28Amblyopia (HP:0000646)3.19272708
29Urinary bladder sphincter dysfunction (HP:0002839)3.18746615
30Hyperventilation (HP:0002883)3.16072626
31Dysdiadochokinesis (HP:0002075)3.15643164
32Abnormal eating behavior (HP:0100738)3.15108509
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14863178
34Polycythemia (HP:0001901)3.07555501
35Impaired social interactions (HP:0000735)3.07465970
36Abnormal social behavior (HP:0012433)3.07465970
37Truncal ataxia (HP:0002078)3.02300544
38Slow saccadic eye movements (HP:0000514)2.99549733
39Dysmetria (HP:0001310)2.99012687
40Postural instability (HP:0002172)2.97999842
41Eczematoid dermatitis (HP:0000976)2.96935392
42Abnormal gallbladder morphology (HP:0012437)2.95252599
43Acanthocytosis (HP:0001927)2.84051804
44Insomnia (HP:0100785)2.79296732
45Gingival bleeding (HP:0000225)2.76732285
46Urinary urgency (HP:0000012)2.75850398
47Epistaxis (HP:0000421)2.71456798
48Purpura (HP:0000979)2.66409881
49Mutism (HP:0002300)2.65346064
50Toxemia of pregnancy (HP:0100603)2.62187128
51Petechiae (HP:0000967)2.60853733
52Hemiparesis (HP:0001269)2.60767910
53Torticollis (HP:0000473)2.58252347
54Bradykinesia (HP:0002067)2.57165681
55Abnormal platelet volume (HP:0011876)2.56548510
56Impaired smooth pursuit (HP:0007772)2.55870085
57Annular pancreas (HP:0001734)2.55665022
58Papilledema (HP:0001085)2.54615677
59Spastic gait (HP:0002064)2.54058479
60Delusions (HP:0000746)2.52070233
61Menorrhagia (HP:0000132)2.50479741
62Status epilepticus (HP:0002133)2.50313465
63Progressive inability to walk (HP:0002505)2.47683213
64Excessive salivation (HP:0003781)2.44784746
65Drooling (HP:0002307)2.44784746
66Absent speech (HP:0001344)2.44478043
67Focal dystonia (HP:0004373)2.44475083
68Scanning speech (HP:0002168)2.42459295
69Abnormality of binocular vision (HP:0011514)2.41991766
70Diplopia (HP:0000651)2.41991766
71Fetal akinesia sequence (HP:0001989)2.40300291
72Tetraplegia (HP:0002445)2.40229637
73Termporal pattern (HP:0011008)2.39627594
74Insidious onset (HP:0003587)2.39627594
75Recurrent abscess formation (HP:0002722)2.39269815
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37180930
77Gastrointestinal infarctions (HP:0005244)2.36419319
78Impaired vibratory sensation (HP:0002495)2.35311641
79Neuronal loss in central nervous system (HP:0002529)2.35227073
80Stereotypic behavior (HP:0000733)2.34198716
81Recurrent bacterial skin infections (HP:0005406)2.33864031
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.30915030
83Genetic anticipation (HP:0003743)2.30058208
84Episodic fever (HP:0001954)2.29199248
85Abnormality of macrophages (HP:0004311)2.27897091
86Polyphagia (HP:0002591)2.26900377
87Epileptiform EEG discharges (HP:0011182)2.26167012
88Intention tremor (HP:0002080)2.23528040
89Cerebral inclusion bodies (HP:0100314)2.22993461
90Limb dystonia (HP:0002451)2.21462382
91Myositis (HP:0100614)2.21072997
92Lower limb muscle weakness (HP:0007340)2.20850237
93Craniofacial dystonia (HP:0012179)2.20170174
94Dysmetric saccades (HP:0000641)2.19164697
95Inability to walk (HP:0002540)2.18428523
96Recurrent gram-negative bacterial infections (HP:0005420)2.16019410
97Abnormality of ocular smooth pursuit (HP:0000617)2.15486573
98Spontaneous hematomas (HP:0007420)2.14735026
99Abnormality of the corticospinal tract (HP:0002492)2.13073929
100Ventricular fibrillation (HP:0001663)2.12723831
101Increased mean platelet volume (HP:0011877)2.11521144
102Increased circulating renin level (HP:0000848)2.11314549
103Incomplete penetrance (HP:0003829)2.11164100
104EEG with generalized epileptiform discharges (HP:0011198)2.10095325
105Abnormality of saccadic eye movements (HP:0000570)2.10068621
106Stomatitis (HP:0010280)2.09635172
107Lower limb amyotrophy (HP:0007210)2.09425467
108Hemiplegia (HP:0002301)2.07850368
109Poikilocytosis (HP:0004447)2.04544281
110Abnormality of the gallbladder (HP:0005264)2.04236092
111Obstructive lung disease (HP:0006536)2.03238591
112Chronic obstructive pulmonary disease (HP:0006510)2.03238591
113Neurofibrillary tangles (HP:0002185)2.03159100
114Resting tremor (HP:0002322)2.01248661
115Orchitis (HP:0100796)2.01016975
116Psychosis (HP:0000709)2.00965128
117Urticaria (HP:0001025)1.99623479
118Hypsarrhythmia (HP:0002521)1.98679143
119Pointed chin (HP:0000307)1.98019052
120Obstructive sleep apnea (HP:0002870)1.97806636
121Generalized myoclonic seizures (HP:0002123)1.97586072
122Difficulty running (HP:0009046)1.92730933
123Paralysis (HP:0003470)1.91406969
124Megalencephaly (HP:0001355)1.90273163
125Pheochromocytoma (HP:0002666)1.88977325
126Akinesia (HP:0002304)1.85499461
127Decreased motor nerve conduction velocity (HP:0003431)1.85065729
128Clonus (HP:0002169)1.84694768
129Reticulocytosis (HP:0001923)1.84114239
130Retrobulbar optic neuritis (HP:0100654)1.84041397
131Optic neuritis (HP:0100653)1.84041397
132Failure to thrive in infancy (HP:0001531)1.79673139
133Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79554124
134Ocular albinism (HP:0001107)1.79479711
135Gait ataxia (HP:0002066)1.77368241
136Cellulitis (HP:0100658)1.76383268
137Protruding tongue (HP:0010808)1.76234468
138Muscle fiber splitting (HP:0003555)1.75825297
139Sleep apnea (HP:0010535)1.75378129
140Rapidly progressive (HP:0003678)1.75327843
141Specific learning disability (HP:0001328)1.75074816
142Peripheral hypomyelination (HP:0007182)1.74537851
143Rigidity (HP:0002063)1.73997322
144Abnormal EKG (HP:0003115)1.73465686
145Abnormal gallbladder physiology (HP:0012438)1.69673859
146Cholecystitis (HP:0001082)1.69673859
147Blue irides (HP:0000635)1.65394749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.09214672
2NTRK34.74657761
3MAP3K93.97274924
4DAPK22.98653665
5MAP3K42.67914659
6MINK12.59237703
7MAP3K112.56791462
8MARK12.54351869
9MAP2K72.27786815
10KSR22.25364650
11MAP2K32.20694163
12PAK62.16843464
13CASK2.10025994
14RIPK41.92607282
15GRK61.91544862
16DAPK11.90031877
17NTRK11.88722293
18MAP3K121.88025205
19NTRK21.86485027
20PRKD31.85826733
21ARAF1.80440915
22TAOK21.76291549
23GRK51.70326746
24MAP2K41.68087129
25CAMKK11.64003337
26TNIK1.58974473
27CDK51.58102255
28KSR11.50583520
29PRPF4B1.47409546
30CDK191.44987872
31MAP3K31.43091404
32PLK21.42357241
33EIF2AK11.42301907
34MAPK131.33182410
35SIK21.29674904
36STK381.27166470
37MAP3K131.25514043
38PRKCG1.21986032
39PNCK1.19781512
40OXSR11.17674481
41TAOK11.16183974
42UHMK11.16001112
43SYK1.12890144
44BMX1.10967544
45MAP4K11.09102425
46FES1.08961377
47RIPK11.08557721
48MAP3K21.06705663
49ERN11.06077298
50PTK2B0.99393769
51SGK2230.98581885
52SGK4940.98581885
53CDK180.97119906
54CDK150.95895099
55TYRO30.94225833
56TRIB30.93056268
57CDK140.92278813
58CAMK2A0.91651932
59CAMK10.88871013
60CAMKK20.88540085
61TNK20.86175641
62RAF10.85893793
63JAK20.85738356
64CDK11A0.85126381
65HCK0.83184494
66PINK10.82881744
67LATS20.82874255
68STK110.82735555
69ZAP700.81314525
70ICK0.78430364
71CAMK2B0.78310898
72WNK30.77102081
73PHKG20.76271663
74PHKG10.76271663
75SGK20.75556146
76SGK10.74862717
77IRAK40.72168131
78BLK0.72100166
79CSK0.71129550
80EPHB10.69458027
81PRKCH0.69253994
82RET0.69061985
83BRSK10.68945661
84SGK30.67142311
85BRAF0.67063472
86BMPR20.66552396
87MARK20.65653481
88PDPK10.62436810
89LMTK20.61852253
90DYRK1B0.61791549
91PDK10.61560777
92MAP3K10.61507604
93HIPK20.61484872
94SIK30.60536108
95DYRK1A0.59892200
96WNK40.59625073
97PRKD20.59593125
98CCNB10.57886897
99BTK0.57196070
100AKT30.57018502
101MAP2K10.55275723
102NEK10.55138436
103ALK0.54242234
104MAP3K50.52637005
105PAK30.52229827
106CDC42BPA0.51682746
107DAPK30.50849604
108MAP3K70.49900368
109WNK10.48362180
110RPS6KA30.47732370
111IRAK20.47345228
112PRKCZ0.45894635
113FGR0.45864133
114JAK10.45747033
115NME10.45680201
116MAP2K60.43894037
117CSNK1G20.43859799
118TYK20.42963828
119CAMK40.40729944
120MAPK100.40223987
121CAMK2G0.39167622
122PRKCE0.39073809
123CAMK1G0.34316342
124FER0.33044874
125CAMK2D0.32710872
126FYN0.32565308
127RPS6KA20.30801775
128MAP3K60.30757520
129MAPKAPK50.30726097
130MAPK120.30653760
131NEK60.30640231

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80028331
2Synaptic vesicle cycle_Homo sapiens_hsa047213.64593518
3Olfactory transduction_Homo sapiens_hsa047403.09350252
4Long-term potentiation_Homo sapiens_hsa047202.72196313
5Circadian entrainment_Homo sapiens_hsa047132.69165967
6GABAergic synapse_Homo sapiens_hsa047272.68560371
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66024984
8Morphine addiction_Homo sapiens_hsa050322.58484633
9Amphetamine addiction_Homo sapiens_hsa050312.57318106
10Glutamatergic synapse_Homo sapiens_hsa047242.55512108
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45226847
12Salivary secretion_Homo sapiens_hsa049702.22478713
13Dopaminergic synapse_Homo sapiens_hsa047282.21449236
14Collecting duct acid secretion_Homo sapiens_hsa049662.04157054
15Insulin secretion_Homo sapiens_hsa049112.00128487
16Gastric acid secretion_Homo sapiens_hsa049711.90866367
17Cholinergic synapse_Homo sapiens_hsa047251.86895572
18Taste transduction_Homo sapiens_hsa047421.82270774
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75385259
20Oxytocin signaling pathway_Homo sapiens_hsa049211.67563302
21Renin secretion_Homo sapiens_hsa049241.66621528
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65512363
23Cocaine addiction_Homo sapiens_hsa050301.65232598
24Serotonergic synapse_Homo sapiens_hsa047261.64086018
25Calcium signaling pathway_Homo sapiens_hsa040201.63440145
26Long-term depression_Homo sapiens_hsa047301.62561057
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57670105
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50856137
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44789928
30GnRH signaling pathway_Homo sapiens_hsa049121.41965214
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41259668
32Gap junction_Homo sapiens_hsa045401.35240523
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32051919
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29259325
35Malaria_Homo sapiens_hsa051441.25385717
36cAMP signaling pathway_Homo sapiens_hsa040241.24635923
37Glioma_Homo sapiens_hsa052141.19602519
38Osteoclast differentiation_Homo sapiens_hsa043801.14910215
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14768753
40Platelet activation_Homo sapiens_hsa046111.11691207
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11503334
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09607700
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09058734
44B cell receptor signaling pathway_Homo sapiens_hsa046621.08650244
45Estrogen signaling pathway_Homo sapiens_hsa049151.07275944
46Cardiac muscle contraction_Homo sapiens_hsa042601.06480900
47Type II diabetes mellitus_Homo sapiens_hsa049301.05939430
48Oocyte meiosis_Homo sapiens_hsa041141.03004288
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02764981
50Axon guidance_Homo sapiens_hsa043601.01654854
51Melanogenesis_Homo sapiens_hsa049161.00165788
52ErbB signaling pathway_Homo sapiens_hsa040121.00136289
53cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95914119
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92462159
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89750397
56Alcoholism_Homo sapiens_hsa050340.89642849
57Vibrio cholerae infection_Homo sapiens_hsa051100.89291130
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.87811041
59Phototransduction_Homo sapiens_hsa047440.87192130
60Dorso-ventral axis formation_Homo sapiens_hsa043200.86292742
61Acute myeloid leukemia_Homo sapiens_hsa052210.83384246
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.82680293
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.81012110
64Tuberculosis_Homo sapiens_hsa051520.80293174
65T cell receptor signaling pathway_Homo sapiens_hsa046600.78737167
66Pancreatic secretion_Homo sapiens_hsa049720.75521709
67Choline metabolism in cancer_Homo sapiens_hsa052310.75154179
68Regulation of autophagy_Homo sapiens_hsa041400.73814159
69Thyroid hormone synthesis_Homo sapiens_hsa049180.73235360
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71708998
71Pancreatic cancer_Homo sapiens_hsa052120.71628899
72Chronic myeloid leukemia_Homo sapiens_hsa052200.70031395
73MAPK signaling pathway_Homo sapiens_hsa040100.69616868
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68877472
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68516803
76Nitrogen metabolism_Homo sapiens_hsa009100.65507254
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65347715
78AMPK signaling pathway_Homo sapiens_hsa041520.64486649
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.62578861
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62193475
81VEGF signaling pathway_Homo sapiens_hsa043700.59772111
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59720314
83HIF-1 signaling pathway_Homo sapiens_hsa040660.58750939
84Leishmaniasis_Homo sapiens_hsa051400.58330353
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.55805979
86Dilated cardiomyopathy_Homo sapiens_hsa054140.55179190
87Glucagon signaling pathway_Homo sapiens_hsa049220.53905261
88Ras signaling pathway_Homo sapiens_hsa040140.52958862
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52441493
90Rap1 signaling pathway_Homo sapiens_hsa040150.50745939
91Non-small cell lung cancer_Homo sapiens_hsa052230.50704084
92Prolactin signaling pathway_Homo sapiens_hsa049170.49290580
93Endocytosis_Homo sapiens_hsa041440.49198717
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48946347
95FoxO signaling pathway_Homo sapiens_hsa040680.48944412
96Bile secretion_Homo sapiens_hsa049760.48771588
97Phagosome_Homo sapiens_hsa041450.48658296
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48212944
99Alzheimers disease_Homo sapiens_hsa050100.47866056
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46888787
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46789944
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.45887712
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45184905
104mTOR signaling pathway_Homo sapiens_hsa041500.43547885
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42787336
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39709055
107Circadian rhythm_Homo sapiens_hsa047100.38785958
108Insulin signaling pathway_Homo sapiens_hsa049100.38456660
109Endometrial cancer_Homo sapiens_hsa052130.37190818
110Prion diseases_Homo sapiens_hsa050200.37127876
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36498393
112Type I diabetes mellitus_Homo sapiens_hsa049400.35888318
113Wnt signaling pathway_Homo sapiens_hsa043100.34605395
114Oxidative phosphorylation_Homo sapiens_hsa001900.33421086
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31682867
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31375515
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.30097315
118Renal cell carcinoma_Homo sapiens_hsa052110.29388471
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29273513
120Parkinsons disease_Homo sapiens_hsa050120.29102902
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28150143
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28053743
123African trypanosomiasis_Homo sapiens_hsa051430.27568490
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26858433
125Chemokine signaling pathway_Homo sapiens_hsa040620.26653958
126Ovarian steroidogenesis_Homo sapiens_hsa049130.21012277

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