DMRTC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.30325866
2proline metabolic process (GO:0006560)8.23095203
3embryonic process involved in female pregnancy (GO:0060136)8.03937609
4replication fork processing (GO:0031297)7.81868384
5positive regulation of protein homooligomerization (GO:0032464)7.20406937
6regulation of integrin activation (GO:0033623)6.71629676
7establishment of apical/basal cell polarity (GO:0035089)6.69028231
8oxidative demethylation (GO:0070989)6.54735432
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.31564515
10regulation of protein homooligomerization (GO:0032462)6.20849550
11DNA deamination (GO:0045006)6.16589188
12glutamate secretion (GO:0014047)5.97806266
13establishment of monopolar cell polarity (GO:0061162)5.83188844
14establishment or maintenance of monopolar cell polarity (GO:0061339)5.83188844
15synaptic vesicle maturation (GO:0016188)5.73140473
16synaptic vesicle docking involved in exocytosis (GO:0016081)5.67314446
17DNA strand renaturation (GO:0000733)5.60945290
18poly(A)+ mRNA export from nucleus (GO:0016973)5.57329692
19mitochondrial DNA metabolic process (GO:0032042)5.48109392
20somatic hypermutation of immunoglobulin genes (GO:0016446)5.37052844
21somatic diversification of immune receptors via somatic mutation (GO:0002566)5.37052844
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.97271546
23negative regulation of JAK-STAT cascade (GO:0046426)4.96380223
24cellular response to ATP (GO:0071318)4.96378134
25mitotic G1 DNA damage checkpoint (GO:0031571)4.93546644
26embryonic placenta development (GO:0001892)4.78189640
27synaptic vesicle exocytosis (GO:0016079)4.71885588
28regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70126106
29negative regulation of cell cycle arrest (GO:0071157)4.69226290
30negative regulation of protein oligomerization (GO:0032460)4.64541395
31viral mRNA export from host cell nucleus (GO:0046784)4.60770836
32neurotransmitter secretion (GO:0007269)4.55126080
33negative regulation of Ras GTPase activity (GO:0034261)4.54291757
34regulation of synaptic vesicle exocytosis (GO:2000300)4.47861291
35DNA integration (GO:0015074)4.46750299
36G1 DNA damage checkpoint (GO:0044783)4.45668554
37mitotic G1/S transition checkpoint (GO:0044819)4.37625034
38glutamine family amino acid biosynthetic process (GO:0009084)4.35150930
39mRNA cleavage (GO:0006379)4.24060731
40spliceosomal tri-snRNP complex assembly (GO:0000244)4.22601127
41positive regulation of protein oligomerization (GO:0032461)4.16582136
42regulation of protein oligomerization (GO:0032459)4.12687000
43convergent extension (GO:0060026)4.08702069
44glial cell migration (GO:0008347)4.08582550
45establishment of protein localization to mitochondrial membrane (GO:0090151)4.08481684
46positive regulation of neurotransmitter transport (GO:0051590)4.07905009
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.06545478
48regulation of sister chromatid cohesion (GO:0007063)4.05603455
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.05599099
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.05599099
51positive regulation of mitotic sister chromatid separation (GO:1901970)4.05599099
52cellular response to zinc ion (GO:0071294)4.05299208
53neuronal action potential propagation (GO:0019227)4.04381134
54embryonic camera-type eye development (GO:0031076)4.02357442
55base-excision repair (GO:0006284)4.02291839
56negative regulation of fatty acid biosynthetic process (GO:0045717)3.99196745
57meiotic chromosome segregation (GO:0045132)3.98985724
58positive regulation of neurotransmitter secretion (GO:0001956)3.98760034
59DNA double-strand break processing (GO:0000729)3.97158858
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96933424
61face development (GO:0060324)3.95741645
62locomotory exploration behavior (GO:0035641)3.95448407
63glycerophospholipid catabolic process (GO:0046475)3.93021627
64regulation of translational fidelity (GO:0006450)3.92283241
65regulation of synaptic vesicle transport (GO:1902803)3.89220911
66protein localization to synapse (GO:0035418)3.85365779
67base-excision repair, AP site formation (GO:0006285)3.84611302
68dendritic spine morphogenesis (GO:0060997)3.81607644
69positive regulation of developmental pigmentation (GO:0048087)3.79201405
70positive regulation by host of viral transcription (GO:0043923)3.78597793
71histone H4-K12 acetylation (GO:0043983)3.77258705
72exploration behavior (GO:0035640)3.75876985
73non-recombinational repair (GO:0000726)3.74327705
74double-strand break repair via nonhomologous end joining (GO:0006303)3.74327705
75synaptic transmission, glutamatergic (GO:0035249)3.70444404
76regulation of RNA export from nucleus (GO:0046831)3.69709174
77pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.68200354
78negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67298858
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.66745013
80detection of calcium ion (GO:0005513)3.65332912
81startle response (GO:0001964)3.63691468
82negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59820729
83regulation of cAMP-dependent protein kinase activity (GO:2000479)3.58645580
84potassium ion homeostasis (GO:0055075)3.58078534
85positive regulation of DNA repair (GO:0045739)3.57392514
86regulation of synapse structural plasticity (GO:0051823)3.56723436
87neuron-neuron synaptic transmission (GO:0007270)3.56651234
88neurotransmitter transport (GO:0006836)3.54505321
89central nervous system myelination (GO:0022010)3.53761620
90axon ensheathment in central nervous system (GO:0032291)3.53761620
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.53000842
92trophectodermal cell differentiation (GO:0001829)3.51680344
93maturation of 5.8S rRNA (GO:0000460)3.50752225
94labyrinthine layer development (GO:0060711)3.50102320
95dosage compensation (GO:0007549)3.49979855
96activation of Rac GTPase activity (GO:0032863)3.48220644
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46539389
98formation of translation preinitiation complex (GO:0001731)3.45722503
99negative regulation of cytosolic calcium ion concentration (GO:0051481)3.45653185
100DNA topological change (GO:0006265)3.44632296
101negative regulation of heart rate (GO:0010459)3.43347876
102anatomical structure regression (GO:0060033)3.43136912
103regulation of neurotransmitter levels (GO:0001505)3.42949804
104mitochondrial RNA metabolic process (GO:0000959)3.42576845
105telomere maintenance via semi-conservative replication (GO:0032201)3.41848046
106apoptotic process involved in morphogenesis (GO:0060561)3.41507904
107cellular potassium ion homeostasis (GO:0030007)3.41341633
108regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40203679
109regulation of neuronal synaptic plasticity (GO:0048168)3.40100109
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.38579933
111response to gravity (GO:0009629)3.37384901
112nucleotide-excision repair, DNA gap filling (GO:0006297)3.37234285
113transmission of nerve impulse (GO:0019226)3.37034479
114negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33489452
115auditory receptor cell stereocilium organization (GO:0060088)3.32956761
116regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.32220564
117regulation of double-strand break repair (GO:2000779)3.31815899
118positive regulation of receptor recycling (GO:0001921)3.31374755
119neurotransmitter-gated ion channel clustering (GO:0072578)3.31326902
120regulation of vesicle fusion (GO:0031338)3.30363770
121negative regulation of mRNA processing (GO:0050686)3.30327028
122positive regulation of synapse maturation (GO:0090129)3.29654677
123membrane hyperpolarization (GO:0060081)3.27884254
124protein targeting to vacuole (GO:0006623)3.27656845
125protein targeting to lysosome (GO:0006622)3.27656845
126establishment of protein localization to vacuole (GO:0072666)3.27656845
127positive regulation of membrane potential (GO:0045838)3.27075891
128auditory behavior (GO:0031223)3.27053192
129regulation of neurotransmitter secretion (GO:0046928)3.26176175
130glutamate receptor signaling pathway (GO:0007215)3.23619469
131nodal signaling pathway (GO:0038092)3.23335742
132termination of RNA polymerase II transcription (GO:0006369)3.23204430
133alkaloid metabolic process (GO:0009820)3.23002276
134vocalization behavior (GO:0071625)3.22814360
135regulation of long-term neuronal synaptic plasticity (GO:0048169)3.22439248
136neuron cell-cell adhesion (GO:0007158)3.21351002
137DNA ligation (GO:0006266)3.19991649
138negative regulation of response to food (GO:0032096)3.18986531
139negative regulation of appetite (GO:0032099)3.18986531
140signal complex assembly (GO:0007172)3.18496050
141regulation of mitochondrial depolarization (GO:0051900)3.18393754
142regulation of neurotransmitter transport (GO:0051588)3.13495187
143sulfur amino acid catabolic process (GO:0000098)3.12786659
144neuromuscular process controlling posture (GO:0050884)3.12370718
145kinetochore assembly (GO:0051382)3.12354526
146regulation of gene silencing by RNA (GO:0060966)3.11390024
147regulation of posttranscriptional gene silencing (GO:0060147)3.11390024
148regulation of gene silencing by miRNA (GO:0060964)3.11390024
149membrane depolarization during action potential (GO:0086010)3.11084360
150regulation of respiratory system process (GO:0044065)3.10239763
151regulation of podosome assembly (GO:0071801)3.09919979
152regulation of glutamate receptor signaling pathway (GO:1900449)3.09031542
153DNA demethylation (GO:0080111)3.08895244
154prepulse inhibition (GO:0060134)3.08668621
155proline transport (GO:0015824)3.08453479
156neuronal ion channel clustering (GO:0045161)3.07840820
157protein localization to endosome (GO:0036010)3.06985164
158hypotonic response (GO:0006971)3.06844686
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06151293
160establishment of mitochondrion localization (GO:0051654)3.05644201
161postsynaptic membrane organization (GO:0001941)3.04430467
162potassium ion import (GO:0010107)3.02549896
163gamma-aminobutyric acid transport (GO:0015812)3.01495525
164calcium ion-dependent exocytosis (GO:0017156)2.97429718
165potassium ion export (GO:0071435)2.95154128
166insulin secretion (GO:0030073)2.94064434
167regulation of postsynaptic membrane potential (GO:0060078)2.94008156
168axonal fasciculation (GO:0007413)2.93180500
169regulation of calcium ion-dependent exocytosis (GO:0017158)2.89009429
170mechanosensory behavior (GO:0007638)2.87821113
171long-term synaptic potentiation (GO:0060291)2.86989059
172regulation of voltage-gated calcium channel activity (GO:1901385)2.82907371
173synaptic transmission (GO:0007268)2.82662784
174regulation of synapse maturation (GO:0090128)2.81921697
175signal release (GO:0023061)2.78332565
176serotonin metabolic process (GO:0042428)2.77771323
177cerebellar granule cell differentiation (GO:0021707)2.77482058
178innervation (GO:0060384)2.77083428
179regulation of respiratory gaseous exchange (GO:0043576)2.77063449
180positive regulation of dendritic spine development (GO:0060999)2.76711762
181glycosphingolipid biosynthetic process (GO:0006688)2.74795289
182regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74749926
183gamma-aminobutyric acid signaling pathway (GO:0007214)2.74225587
184cellular ketone body metabolic process (GO:0046950)2.73770710
185regulation of synaptic plasticity (GO:0048167)2.73461698
186presynaptic membrane organization (GO:0097090)2.72523784
187response to auditory stimulus (GO:0010996)2.71310443
188protein polyglutamylation (GO:0018095)2.70904084
189righting reflex (GO:0060013)2.70778115
190synaptic vesicle endocytosis (GO:0048488)2.70314135
191positive regulation of dendritic spine morphogenesis (GO:0061003)2.70114735
192neuromuscular synaptic transmission (GO:0007274)2.70028083
193regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69604294
194membrane depolarization (GO:0051899)2.67279326
195potassium ion transmembrane transport (GO:0071805)2.65751883
196cellular potassium ion transport (GO:0071804)2.65751883
197neuron recognition (GO:0008038)2.64804275
198primary amino compound metabolic process (GO:1901160)2.63603589
199nephron tubule morphogenesis (GO:0072078)2.63528815
200proline biosynthetic process (GO:0006561)10.8090824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22719930
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.72355548
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.63628167
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.60164374
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.53565184
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.51718055
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.51718055
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.51718055
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.08268174
10REST_21632747_ChIP-Seq_MESCs_Mouse3.06668433
11GBX2_23144817_ChIP-Seq_PC3_Human2.91070877
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70474580
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.70103141
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.61901394
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61057173
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.50782411
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.48816440
18POU5F1_16518401_ChIP-PET_MESCs_Mouse2.48377666
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.45659340
20VDR_21846776_ChIP-Seq_THP-1_Human2.41765672
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40290789
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39881962
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.37001863
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.31371624
25TCF3_18692474_ChIP-Seq_MESCs_Mouse2.31065662
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.29092789
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25249987
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.24735975
29IGF1R_20145208_ChIP-Seq_DFB_Human2.23383553
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19853992
31JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19249794
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.18280188
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14647298
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.05301832
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05030584
36IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04881306
37LXR_22292898_ChIP-Seq_THP-1_Human2.03631701
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02047615
39MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02046132
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98798272
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.98590178
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.98117061
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.93221667
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.91999130
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.91845427
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.91761186
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91568866
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90897882
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89437276
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89204382
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89204382
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87950466
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.87512443
54NANOG_21062744_ChIP-ChIP_HESCs_Human1.87178893
55TAF15_26573619_Chip-Seq_HEK293_Human1.82995412
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82526377
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81894948
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.81709280
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81279829
60DROSHA_22980978_ChIP-Seq_HELA_Human1.79414275
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75140347
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.74279573
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72611817
64RNF2_27304074_Chip-Seq_NSC_Mouse1.67981449
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65040650
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.63576805
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63229178
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61269733
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.61120088
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58632299
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58485894
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56453725
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55839938
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.55520397
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.55406065
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53772340
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53496783
78RACK7_27058665_Chip-Seq_MCF-7_Human1.52750467
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52024200
80ZNF263_19887448_ChIP-Seq_K562_Human1.50370082
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48619592
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.47740052
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46162894
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45281282
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44638322
86NANOG_18692474_ChIP-Seq_MESCs_Mouse1.43485380
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42060847
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41158267
89SMAD4_21799915_ChIP-Seq_A2780_Human1.41108889
90P300_19829295_ChIP-Seq_ESCs_Human1.41071301
91RXRA_24833708_ChIP-Seq_LIVER_Mouse1.40616119
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38820405
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.38259470
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37334105
95PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.36122134
96SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35729989
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.35240760
98MYC_22102868_ChIP-Seq_BL_Human1.34829491
99SOX2_18692474_ChIP-Seq_MESCs_Mouse1.31421915
100ETS1_21867929_ChIP-Seq_TH2_Mouse1.31126998
101KDM2B_26808549_Chip-Seq_DND41_Human1.30579805
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.29298359
103RARB_24833708_ChIP-Seq_LIVER_Mouse1.28745363
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26389725
105SPI1_26923725_Chip-Seq_HPCs_Mouse1.24710473
106MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23366744
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23345308
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23122333
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22568455
110AR_25329375_ChIP-Seq_VCAP_Human1.21611083
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.21119646
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21107562
113TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20151348
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20018742
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19565581
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17896850
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17665603
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.17430230
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16627843
120FUS_26573619_Chip-Seq_HEK293_Human1.16542719
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16539847
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16318102
123RARA_24833708_ChIP-Seq_LIVER_Mouse1.15288035
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14894587
125FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14618766
126NANOG_16518401_ChIP-PET_MESCs_Mouse1.13749915
127STAT3_23295773_ChIP-Seq_U87_Human1.13587682
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13467260
129THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13106180
130ZNF274_21170338_ChIP-Seq_K562_Hela1.12063601
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10683530
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09905401
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09643615
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.09315691
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09304277
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09071323
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08485525
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08337588
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08269696
140CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08039904
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07836440
142NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07644139
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06846957
144YY1_21170310_ChIP-Seq_MESCs_Mouse1.06686233
145OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06429267
146P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06120666
147TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05979438
148SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05556104
149KDM2B_26808549_Chip-Seq_K562_Human1.05369741
150TAL1_26923725_Chip-Seq_HPCs_Mouse1.04164336
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03969842
152KAP1_27257070_Chip-Seq_ESCs_Mouse1.03812099
153EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03688185
154CDX2_20551321_ChIP-Seq_CACO-2_Human1.03311267
155TCF4_23295773_ChIP-Seq_U87_Human1.03124515
156E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01089657
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00521638
158AR_19668381_ChIP-Seq_PC3_Human1.00466021
159NANOG_18555785_Chip-Seq_ESCs_Mouse1.00235640
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99521456
161NANOG_18692474_ChIP-Seq_MEFs_Mouse0.99102304
162E2F7_22180533_ChIP-Seq_HELA_Human0.98449169
163STAT1_20625510_ChIP-Seq_HELA_Human0.98404561
164ELK3_25401928_ChIP-Seq_HUVEC_Human0.98154424
165PHF8_20622854_ChIP-Seq_HELA_Human0.98000400
166E2F1_20622854_ChIP-Seq_HELA_Human0.97940516
167WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97806708
168FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96622451
169STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96437322
170AR_21572438_ChIP-Seq_LNCaP_Human0.95746949
171POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95414528
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95414528
173VDR_22108803_ChIP-Seq_LS180_Human0.95237674
174BCOR_27268052_Chip-Seq_Bcells_Human0.94791959
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94746703
176FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94448103
177RUNX2_22187159_ChIP-Seq_PCA_Human0.94186613
178UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93858940
179TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93743552
180PRDM14_20953172_ChIP-Seq_ESCs_Human0.93061485
181MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92169048
182CTCF_27219007_Chip-Seq_Bcells_Human0.90970273
183TRIM28_21343339_ChIP-Seq_HEK293_Human0.90893876
184HTT_18923047_ChIP-ChIP_STHdh_Human0.90710233
185ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89913855
186JUN_21703547_ChIP-Seq_K562_Human0.89863129
187CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89667105
188SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89518648
189LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89466426
190BCAT_22108803_ChIP-Seq_LS180_Human0.89169445
191EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88749686
192EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87827462
193OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87420966
194SMAD4_21741376_ChIP-Seq_HESCs_Human0.86249370
195TCF4_22108803_ChIP-Seq_LS180_Human0.86150076
196MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85612898
197ER_23166858_ChIP-Seq_MCF-7_Human0.85473072

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.18667857
2MP0005171_absent_coat_pigmentation5.30068593
3MP0009278_abnormal_bone_marrow4.51101714
4MP0004859_abnormal_synaptic_plasticity4.14353852
5MP0010030_abnormal_orbit_morphology4.12544094
6MP0004233_abnormal_muscle_weight3.73367368
7MP0004270_analgesia3.50183506
8MP0003880_abnormal_central_pattern3.47913659
9MP0002009_preneoplasia3.16101367
10MP0003635_abnormal_synaptic_transmissio3.06980882
11MP0003787_abnormal_imprinting3.02754595
12MP0002064_seizures2.88546792
13MP0008995_early_reproductive_senescence2.84220959
14MP0003122_maternal_imprinting2.79233679
15MP0009745_abnormal_behavioral_response2.78411699
16MP0009046_muscle_twitch2.78092955
17MP0002272_abnormal_nervous_system2.70172183
18MP0001968_abnormal_touch/_nociception2.66698236
19MP0005423_abnormal_somatic_nervous2.66556016
20MP0002734_abnormal_mechanical_nocicepti2.60566657
21MP0003890_abnormal_embryonic-extraembry2.60455354
22MP0002653_abnormal_ependyma_morphology2.44954911
23MP0002063_abnormal_learning/memory/cond2.40957322
24MP0001486_abnormal_startle_reflex2.35463160
25MP0002572_abnormal_emotion/affect_behav2.33739664
26MP0003283_abnormal_digestive_organ2.32538590
27MP0009780_abnormal_chondrocyte_physiolo2.32022804
28MP0002249_abnormal_larynx_morphology2.28140233
29MP0002909_abnormal_adrenal_gland2.21401645
30MP0006072_abnormal_retinal_apoptosis2.18777664
31MP0005174_abnormal_tail_pigmentation2.18410680
32MP0005397_hematopoietic_system_phenotyp2.17169363
33MP0001545_abnormal_hematopoietic_system2.17169363
34MP0010094_abnormal_chromosome_stability2.16584096
35MP0004133_heterotaxia2.05622114
36MP0001970_abnormal_pain_threshold2.03313231
37MP0003119_abnormal_digestive_system2.01044632
38MP0008877_abnormal_DNA_methylation1.99588098
39MP0002557_abnormal_social/conspecific_i1.99584817
40MP0003453_abnormal_keratinocyte_physiol1.99551141
41MP0002282_abnormal_trachea_morphology1.99317165
42MP0000579_abnormal_nail_morphology1.98447100
43MP0003786_premature_aging1.92483263
44MP0002733_abnormal_thermal_nociception1.90764274
45MP0001501_abnormal_sleep_pattern1.87653959
46MP0002102_abnormal_ear_morphology1.78902250
47MP0005076_abnormal_cell_differentiation1.75927928
48MP0002736_abnormal_nociception_after1.75798523
49MP0002735_abnormal_chemical_nociception1.74280567
50MP0006276_abnormal_autonomic_nervous1.70529160
51MP0002837_dystrophic_cardiac_calcinosis1.69110997
52MP0004885_abnormal_endolymph1.68172092
53MP0004957_abnormal_blastocyst_morpholog1.66828607
54MP0002086_abnormal_extraembryonic_tissu1.64014978
55MP0000778_abnormal_nervous_system1.63602210
56MP0002084_abnormal_developmental_patter1.63122805
57MP0002139_abnormal_hepatobiliary_system1.60961225
58MP0005551_abnormal_eye_electrophysiolog1.60407873
59MP0001984_abnormal_olfaction1.57688064
60MP0001905_abnormal_dopamine_level1.57359258
61MP0005379_endocrine/exocrine_gland_phen1.56845293
62MP0005646_abnormal_pituitary_gland1.56711389
63MP0003121_genomic_imprinting1.55732214
64MP0000462_abnormal_digestive_system1.55646298
65MP0001188_hyperpigmentation1.53157048
66MP0001697_abnormal_embryo_size1.51396115
67MP0002067_abnormal_sensory_capabilities1.50407441
68MP0002254_reproductive_system_inflammat1.50339506
69MP0004142_abnormal_muscle_tone1.49913577
70MP0001293_anophthalmia1.48590195
71MP0005386_behavior/neurological_phenoty1.48047176
72MP0004924_abnormal_behavior1.48047176
73MP0002085_abnormal_embryonic_tissue1.47354554
74MP0002822_catalepsy1.46131329
75MP0008058_abnormal_DNA_repair1.44007833
76MP0004197_abnormal_fetal_growth/weight/1.41824882
77MP0001986_abnormal_taste_sensitivity1.40892309
78MP0010352_gastrointestinal_tract_polyps1.40619695
79MP0000470_abnormal_stomach_morphology1.38209123
80MP0002796_impaired_skin_barrier1.36702557
81MP0000639_abnormal_adrenal_gland1.36485183
82MP0000955_abnormal_spinal_cord1.35929243
83MP0008932_abnormal_embryonic_tissue1.34303931
84MP0003172_abnormal_lysosome_physiology1.33762033
85MP0003111_abnormal_nucleus_morphology1.32543536
86MP0001440_abnormal_grooming_behavior1.32147671
87MP0000015_abnormal_ear_pigmentation1.31180103
88MP0004811_abnormal_neuron_physiology1.30452190
89MP0000490_abnormal_crypts_of1.29327774
90MP0003567_abnormal_fetal_cardiomyocyte1.27256954
91MP0001340_abnormal_eyelid_morphology1.27209336
92MP0003123_paternal_imprinting1.26905010
93MP0002269_muscular_atrophy1.26398814
94MP0002638_abnormal_pupillary_reflex1.26138924
95MP0002184_abnormal_innervation1.25989607
96MP0004264_abnormal_extraembryonic_tissu1.25574844
97MP0000371_diluted_coat_color1.24108509
98MP0002882_abnormal_neuron_morphology1.24017859
99MP0005058_abnormal_lysosome_morphology1.22970924
100MP0002066_abnormal_motor_capabilities/c1.20770691
101MP0004147_increased_porphyrin_level1.19029852
102MP0005380_embryogenesis_phenotype1.18133082
103MP0001672_abnormal_embryogenesis/_devel1.18133082
104MP0001529_abnormal_vocalization1.17953437
105MP0008569_lethality_at_weaning1.16921848
106MP0001502_abnormal_circadian_rhythm1.16718584
107MP0004742_abnormal_vestibular_system1.15972681
108MP0001485_abnormal_pinna_reflex1.15723978
109MP0002111_abnormal_tail_morphology1.14195976
110MP0003633_abnormal_nervous_system1.14152221
111MP0002693_abnormal_pancreas_physiology1.12765038
112MP0005075_abnormal_melanosome_morpholog1.10608952
113MP0002876_abnormal_thyroid_physiology1.10160837
114MP0000013_abnormal_adipose_tissue1.09294746
115MP0003879_abnormal_hair_cell1.08653111
116MP0003718_maternal_effect1.08089912
117MP0003045_fibrosis1.07128937
118MP0001944_abnormal_pancreas_morphology1.07127986
119MP0003828_pulmonary_edema1.05627748
120MP0002069_abnormal_eating/drinking_beha1.04439944
121MP0000762_abnormal_tongue_morphology1.04429307
122MP0000631_abnormal_neuroendocrine_gland1.04111213
123MP0002932_abnormal_joint_morphology1.03883517
124MP0005085_abnormal_gallbladder_physiolo1.03366632
125MP0003755_abnormal_palate_morphology1.01816651
126MP0005084_abnormal_gallbladder_morpholo1.00307258
127MP0003329_amyloid_beta_deposits0.99702113
128MP0003077_abnormal_cell_cycle0.96401552
129MP0005499_abnormal_olfactory_system0.95492531
130MP0005394_taste/olfaction_phenotype0.95492531
131MP0002928_abnormal_bile_duct0.94976409
132MP0001963_abnormal_hearing_physiology0.94399161
133MP0003935_abnormal_craniofacial_develop0.93581648
134MP0002229_neurodegeneration0.93400775
135MP0004043_abnormal_pH_regulation0.93053570
136MP0002114_abnormal_axial_skeleton0.91671031
137MP0000350_abnormal_cell_proliferation0.90112026
138MP0005645_abnormal_hypothalamus_physiol0.90051875
139MP0002116_abnormal_craniofacial_bone0.89177757
140MP0002152_abnormal_brain_morphology0.89148620
141MP0000566_synostosis0.88175482
142MP0005365_abnormal_bile_salt0.87485420
143MP0002060_abnormal_skin_morphology0.86859595
144MP0001730_embryonic_growth_arrest0.86508649
145MP0003984_embryonic_growth_retardation0.86490460
146MP0010386_abnormal_urinary_bladder0.85988505
147MP0002019_abnormal_tumor_incidence0.85475883
148MP0002075_abnormal_coat/hair_pigmentati0.85229178
149MP0003631_nervous_system_phenotype0.85043025
150MP0002163_abnormal_gland_morphology0.84893195
151MP0005266_abnormal_metabolism0.84367752
152MP0002080_prenatal_lethality0.82587644
153MP0005448_abnormal_energy_balance0.82485248
154MP0005535_abnormal_body_temperature0.82229317
155MP0002752_abnormal_somatic_nervous0.82193428
156MP0002088_abnormal_embryonic_growth/wei0.81365326
157MP0009115_abnormal_fat_cell0.81304243
158MP0008872_abnormal_physiological_respon0.80443135
159MP0003137_abnormal_impulse_conducting0.79725361
160MP0001145_abnormal_male_reproductive0.79657986
161MP0005501_abnormal_skin_physiology0.79486081
162MP0000432_abnormal_head_morphology0.78730456
163MP0010329_abnormal_lipoprotein_level0.77809378
164MP0001324_abnormal_eye_pigmentation0.75637290
165MP0003385_abnormal_body_wall0.74974307
166MP0009379_abnormal_foot_pigmentation0.73598023
167MP0001186_pigmentation_phenotype0.73325244
168MP0005508_abnormal_skeleton_morphology0.72877077
169MP0003656_abnormal_erythrocyte_physiolo0.72540225
170MP0004185_abnormal_adipocyte_glucose0.71649327
171MP0000467_abnormal_esophagus_morphology0.71319575
172MP0003011_delayed_dark_adaptation0.69378916
173MP0002332_abnormal_exercise_endurance0.69146209
174MP0000026_abnormal_inner_ear0.67839323
175MP0002078_abnormal_glucose_homeostasis0.67587361
176MP0003699_abnormal_female_reproductive0.66006025
177MP0010630_abnormal_cardiac_muscle0.65202721
178MP0003693_abnormal_embryo_hatching0.65108553
179MP0001929_abnormal_gametogenesis0.64598960
180MP0008789_abnormal_olfactory_epithelium0.64471339
181MP0004145_abnormal_muscle_electrophysio0.63316268
182MP0002405_respiratory_system_inflammati0.62949265
183MP0003953_abnormal_hormone_level0.62276814
184MP0000653_abnormal_sex_gland0.61854711
185MP0003136_yellow_coat_color0.60962632
186MP0005253_abnormal_eye_physiology0.60818109
187MP0005330_cardiomyopathy0.60678750
188MP0006082_CNS_inflammation0.59792098
189MP0002210_abnormal_sex_determination0.59423858
190MP0004019_abnormal_vitamin_homeostasis0.58923121
191MP0000516_abnormal_urinary_system0.58706314

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.89947335
2Myokymia (HP:0002411)5.55425085
3Facial hemangioma (HP:0000329)5.42342729
4Annular pancreas (HP:0001734)5.40186009
5Concave nail (HP:0001598)5.39053569
6Pustule (HP:0200039)5.37600883
7Rectal fistula (HP:0100590)5.02709029
8Rectovaginal fistula (HP:0000143)5.02709029
9Turricephaly (HP:0000262)5.00345867
10Increased IgM level (HP:0003496)4.96590375
11Focal motor seizures (HP:0011153)4.77956643
12Alopecia of scalp (HP:0002293)4.65744007
13Poikiloderma (HP:0001029)4.62096171
14Intestinal fistula (HP:0100819)4.59815016
15Vaginal fistula (HP:0004320)4.45235267
16Ulnar bowing (HP:0003031)4.43026239
17Male infertility (HP:0003251)4.37598448
18Hypochromic microcytic anemia (HP:0004840)4.34845157
19Coronal craniosynostosis (HP:0004440)4.28533013
20Focal seizures (HP:0007359)4.27749763
21Febrile seizures (HP:0002373)4.27218052
22Polyphagia (HP:0002591)4.14771857
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.14750893
24Atonic seizures (HP:0010819)4.08049208
25Action tremor (HP:0002345)3.95959540
26Short humerus (HP:0005792)3.88969824
27Tongue fasciculations (HP:0001308)3.87341491
28Aplasia/hypoplasia of the humerus (HP:0006507)3.69621494
29Anteriorly placed anus (HP:0001545)3.61520946
30Muscle fibrillation (HP:0010546)3.61422590
31Abnormal eating behavior (HP:0100738)3.59998035
32Epileptic encephalopathy (HP:0200134)3.59935870
33Intestinal atresia (HP:0011100)3.59881088
34Abnormal hemoglobin (HP:0011902)3.56724228
35Orthostatic hypotension (HP:0001278)3.53947729
36Alacrima (HP:0000522)3.43272342
37Abnormality of male internal genitalia (HP:0000022)3.40162808
38Absent radius (HP:0003974)3.30995041
39Limb dystonia (HP:0002451)3.27314251
40Vertebral hypoplasia (HP:0008417)3.26900713
41Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.26900713
42Short chin (HP:0000331)3.26370342
43Dialeptic seizures (HP:0011146)3.21531289
44Hemiparesis (HP:0001269)3.21154429
45Progressive cerebellar ataxia (HP:0002073)3.18948561
46Mucopolysacchariduria (HP:0008155)3.15316700
47Urinary glycosaminoglycan excretion (HP:0003541)3.15316700
48Absent forearm bone (HP:0003953)3.12401813
49Aplasia involving forearm bones (HP:0009822)3.12401813
50Methylmalonic acidemia (HP:0002912)3.12307793
51Absence seizures (HP:0002121)3.10543238
52Congenital hip dislocation (HP:0001374)3.07456163
53Squamous cell carcinoma (HP:0002860)3.06147097
54Abnormality of the aortic arch (HP:0012303)3.05340153
55Generalized tonic-clonic seizures (HP:0002069)3.01810685
56Hypotrichosis (HP:0001006)3.01415286
57Intention tremor (HP:0002080)2.96262322
58Dysautonomia (HP:0002459)2.96061563
59Broad alveolar ridges (HP:0000187)2.91948919
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88534358
61Abnormality of polysaccharide metabolism (HP:0011012)2.88534358
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88534358
63Chronic hepatic failure (HP:0100626)2.85820264
64Large for gestational age (HP:0001520)2.85729607
65Epileptiform EEG discharges (HP:0011182)2.82877589
66Ankle clonus (HP:0011448)2.82108284
67Capillary hemangiomas (HP:0005306)2.79067688
68Pancreatic islet-cell hyperplasia (HP:0004510)2.78532218
69Absent thumb (HP:0009777)2.78522286
70Impaired vibration sensation in the lower limbs (HP:0002166)2.77562277
71Papilledema (HP:0001085)2.76712528
72Dysostosis multiplex (HP:0000943)2.75079146
73Choanal stenosis (HP:0000452)2.74096702
74Abnormal drinking behavior (HP:0030082)2.74027016
75Polydipsia (HP:0001959)2.74027016
76Clumsiness (HP:0002312)2.73805519
77Hamartoma (HP:0010566)2.73713300
78Volvulus (HP:0002580)2.73518112
79Albinism (HP:0001022)2.72113547
80Premature skin wrinkling (HP:0100678)2.71971469
81Methylmalonic aciduria (HP:0012120)2.71444623
82Bifid uvula (HP:0000193)2.70572198
83Double outlet right ventricle (HP:0001719)2.69711317
84Congenital malformation of the right heart (HP:0011723)2.69711317
85Aplasia of the musculature (HP:0100854)2.66023603
86Fetal akinesia sequence (HP:0001989)2.65696940
87Basal cell carcinoma (HP:0002671)2.65513740
88Acute lymphatic leukemia (HP:0006721)2.62328334
89Diaphragmatic weakness (HP:0009113)2.61723610
90Decreased lacrimation (HP:0000633)2.61168545
91Patellar aplasia (HP:0006443)2.60222921
92Increased circulating renin level (HP:0000848)2.57420056
93Joint stiffness (HP:0001387)2.56449406
94Status epilepticus (HP:0002133)2.56208858
95Diplopia (HP:0000651)2.51975411
96Abnormality of binocular vision (HP:0011514)2.51975411
97Narrow nasal bridge (HP:0000446)2.51812315
98Retinal dysplasia (HP:0007973)2.51530272
99EEG with generalized epileptiform discharges (HP:0011198)2.51172118
100Type II lissencephaly (HP:0007260)2.50656214
101Selective tooth agenesis (HP:0001592)2.50206779
102Hypotelorism (HP:0000601)2.48527989
103Abnormality of the labia minora (HP:0012880)2.47338587
104Prolonged QT interval (HP:0001657)2.43863392
105Bowing of the arm (HP:0006488)2.43676131
106Bowed forearm bones (HP:0003956)2.43676131
107Growth hormone excess (HP:0000845)2.43392726
108Popliteal pterygium (HP:0009756)2.43125782
109Polycythemia (HP:0001901)2.42158768
110Supranuclear gaze palsy (HP:0000605)2.41727052
111Pancreatic fibrosis (HP:0100732)2.41030997
112Spastic gait (HP:0002064)2.40537452
113True hermaphroditism (HP:0010459)2.40313058
114Increased number of teeth (HP:0011069)2.39321973
115Hypsarrhythmia (HP:0002521)2.38725934
116Agitation (HP:0000713)2.38246162
117Hyperventilation (HP:0002883)2.38033183
118Hypochromic anemia (HP:0001931)2.38024536
119Glycosuria (HP:0003076)2.37925560
120Abnormality of urine glucose concentration (HP:0011016)2.37925560
121Split hand (HP:0001171)2.37922026
122Aplasia/Hypoplasia of the patella (HP:0006498)2.35723652
123Anxiety (HP:0000739)2.35700626
124Abnormal pancreas size (HP:0012094)2.35552769
125Cerebral aneurysm (HP:0004944)2.35269997
126Ketoacidosis (HP:0001993)2.34601827
127Medial flaring of the eyebrow (HP:0010747)2.34564669
128Vertebral fusion (HP:0002948)2.33985522
129Hypokinesia (HP:0002375)2.33293601
130Premature graying of hair (HP:0002216)2.31175154
131Increased hepatocellular lipid droplets (HP:0006565)2.28321914
132Pancreatic cysts (HP:0001737)2.27287140
133IgA deficiency (HP:0002720)2.26862133
134Abnormal urine output (HP:0012590)2.26217657
135Bulbar palsy (HP:0001283)2.23091005
136Amelogenesis imperfecta (HP:0000705)2.22021222
137Abnormality of vitamin B metabolism (HP:0004340)2.21813052
138Impaired vibratory sensation (HP:0002495)2.21636103
139Amblyopia (HP:0000646)2.21209598
140Muscular hypotonia of the trunk (HP:0008936)2.21095369
141Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19629338
142Dysdiadochokinesis (HP:0002075)2.19166179
143Torticollis (HP:0000473)2.17278187
144Molar tooth sign on MRI (HP:0002419)2.17047927
145Abnormality of midbrain morphology (HP:0002418)2.17047927
146Asymmetric septal hypertrophy (HP:0001670)2.16208826
147Gastrointestinal atresia (HP:0002589)2.15742350
148Postural tremor (HP:0002174)2.13299076
149Lipid accumulation in hepatocytes (HP:0006561)2.11727891
150Nephronophthisis (HP:0000090)2.11273609
151Lower limb hyperreflexia (HP:0002395)2.09911076
152Visual hallucinations (HP:0002367)2.09617629
153Focal dystonia (HP:0004373)2.09460341
154Drooling (HP:0002307)2.08277613
155Urinary bladder sphincter dysfunction (HP:0002839)2.06322350
156Polyuria (HP:0000103)2.05892593
157Abnormality of placental membranes (HP:0011409)2.04950361
158Amniotic constriction ring (HP:0009775)2.04950361
159Spastic tetraplegia (HP:0002510)2.04947724
160Hypoplasia of the ulna (HP:0003022)2.04465614
161Poor suck (HP:0002033)2.03721506
162Gait imbalance (HP:0002141)2.03112035
163Abnormality of the corticospinal tract (HP:0002492)2.02297442
164Short 5th finger (HP:0009237)2.01324411
165Abnormality of renal excretion (HP:0011036)2.01294097
166Hypoplasia of the radius (HP:0002984)2.00797579
167Poor eye contact (HP:0000817)2.00728511
168Postural instability (HP:0002172)1.97465869
169Abnormality of the astrocytes (HP:0100707)1.95801551
170Astrocytoma (HP:0009592)1.95801551
171Renal Fanconi syndrome (HP:0001994)1.94890219
172Abnormal EKG (HP:0003115)1.94817112
173Broad-based gait (HP:0002136)1.94747592
174Clonus (HP:0002169)1.94665704
175Bilateral sensorineural hearing impairment (HP:0008619)1.94060873
176Abnormal respiratory motile cilium morphology (HP:0005938)1.93423468
177Abnormal respiratory epithelium morphology (HP:0012253)1.93423468
178Truncus arteriosus (HP:0001660)1.93294071
179Excessive salivation (HP:0003781)1.91530256
180Diminished movement (HP:0002374)1.91488204
181Resting tremor (HP:0002322)1.90111271
182Hypomagnesemia (HP:0002917)1.89815499
183Dysmetria (HP:0001310)1.88923766
184Neoplasm of the oral cavity (HP:0100649)1.87182535
185Median cleft lip (HP:0000161)1.86852309
186Akinesia (HP:0002304)1.85831918
187Degeneration of the lateral corticospinal tracts (HP:0002314)1.83498069
188Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83498069
189Cystic liver disease (HP:0006706)1.83307068
190Sleep apnea (HP:0010535)1.81097879
191Exertional dyspnea (HP:0002875)1.80682139
192Bradykinesia (HP:0002067)1.79256214
193Abnormality of the renal medulla (HP:0100957)1.78346352
194Depression (HP:0000716)1.78196054
195Neonatal onset (HP:0003623)1.76897959
196Syncope (HP:0001279)1.76860377
197Abnormality of ocular smooth pursuit (HP:0000617)1.76021906
198Craniofacial dystonia (HP:0012179)1.75975262
199Hyperphosphaturia (HP:0003109)1.74491094
200Impaired social interactions (HP:0000735)1.73919134

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.20307913
2MAP3K65.21170982
3DDR25.15969809
4MAPK155.10888089
5DAPK23.79678176
6PINK13.44496073
7MAP3K113.38787297
8TYRO33.22759583
9FGR3.20406883
10NTRK33.16237603
11MATK3.02613599
12MARK12.89555277
13EPHA42.79752249
14CASK2.79088798
15MAP3K42.76425140
16DAPK12.46566607
17PRKD22.40792969
18BMX2.28645544
19UHMK12.19288799
20CSK2.17484306
21PAK32.13168763
22PDGFRA2.11173251
23MINK12.09089808
24PIM21.96857814
25PNCK1.94519097
26ARAF1.86714562
27YES11.85945447
28DYRK1B1.80142985
29PRKCG1.80016017
30TRPM71.79430626
31LATS21.78939264
32SIK21.67360148
33CDK71.64224094
34MAP2K71.59946381
35MAPK131.53522249
36PLK21.52741087
37AKT31.46018853
38MAP3K131.40724045
39CSNK1G21.37120563
40CAMKK11.36611960
41MAP3K121.29910915
42CDK61.25520613
43WNK41.24501163
44CDC42BPA1.23452880
45PIM11.22896829
46MAP2K41.21189586
47FRK1.20985754
48CHEK21.17481053
49PHKG21.16563832
50PHKG11.16563832
51GRK51.16521559
52GRK11.15707191
53KSR11.14721218
54RPS6KC11.12127494
55RPS6KL11.12127494
56CDK51.10372274
57GSK3A1.10138905
58MAPK111.08262389
59CSNK1G31.07117494
60DYRK1A1.02553769
61KSR21.00393674
62SGK2231.00281469
63SGK4941.00281469
64CDK190.99355629
65MAP2K60.98967932
66PRKCE0.97840327
67CAMK10.96730284
68RPS6KA60.96329898
69WNK30.93967457
70PRKD30.92870998
71OXSR10.92785258
72LATS10.91503483
73PRPF4B0.82627811
74CSNK1A1L0.79201330
75PLK10.77980407
76DYRK30.77706285
77SGK20.75569091
78PRKAA10.72989414
79PRKCH0.72498624
80BRAF0.72188871
81NTRK10.72089456
82CDK180.69921462
83FGFR20.69017789
84CDK140.68785650
85RAF10.68375205
86MTOR0.67524712
87STK110.67134220
88STK240.64854976
89HIPK20.64262170
90RPS6KA10.64259899
91MAP3K100.63799204
92STK160.63469935
93STK390.62720928
94CAMKK20.61446035
95MAP3K90.58305276
96STK30.57985753
97TAOK20.56348398
98ERBB20.56287235
99MAP4K20.54577430
100ERBB30.50524561
101STK38L0.49259269
102PKN10.48789128
103PRKACA0.48371115
104TAOK10.48191424
105SIK30.47480815
106CDK120.46492337
107PRKG10.45850884
108PRKCA0.45756308
109PDGFRB0.45228985
110DAPK30.45198916
111RPS6KB20.44645029
112ADRBK20.43726886
113EGFR0.43702205
114CAMK2B0.43566300
115FES0.43193692
116CDK20.42451179
117RPS6KB10.41239080
118CSNK1G10.41062396
119ATR0.40987135
120CAMK2G0.40850246
121STK380.40554810
122PRKAA20.40529845
123LIMK10.38519949
124DYRK20.38058695
125SGK30.37799446
126TRIB30.37569643
127CSNK1E0.37117033
128BCR0.36614282
129MUSK0.36460183
130NEK20.35414514
131CAMK40.35401935
132MAPK10.35275881
133CSNK2A10.34316230
134LYN0.33950293
135PRKCQ0.33415721
136MAPK30.33410753
137CSNK1A10.32863063
138MAPK100.32453345
139PTK2B0.32067999
140TNK20.31719233
141PRKCB0.31384818
142CAMK2A0.30830462
143FYN0.29667225
144MAPK140.29601657
145ATM0.28952078
146MAPK40.27705141
147AURKA0.26225534
148SGK10.25905143
149CHEK10.25750716
150CAMK2D0.25282306
151RIPK10.23854832
152MAPKAPK30.23517765
153INSR0.23076813
154EPHA20.22827993
155CDK10.22313750
156CDK80.22128669
157PTK20.20867076
158DMPK0.19782363
159PRKCZ0.19700215
160CSNK2A20.19255072
161ALK0.18352981
162MAPKAPK20.17585400
163MARK20.17210244
164RPS6KA30.16907377
165GSK3B0.15658867
166NTRK20.15338477
167PAK60.15068977
168PRKD10.15034821
169ABL10.14979428
170CDK11A0.14827841
171CDK150.14351482
172PAK20.13794408

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.30392536
2Base excision repair_Homo sapiens_hsa034104.64762244
3Mismatch repair_Homo sapiens_hsa034304.63976689
4Nicotine addiction_Homo sapiens_hsa050334.07551231
5Synaptic vesicle cycle_Homo sapiens_hsa047213.34836790
6DNA replication_Homo sapiens_hsa030303.18493114
7Insulin secretion_Homo sapiens_hsa049112.86495292
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.83863183
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.78025409
10GABAergic synapse_Homo sapiens_hsa047272.77900878
11Amphetamine addiction_Homo sapiens_hsa050312.64607071
12Morphine addiction_Homo sapiens_hsa050322.53842881
13Circadian entrainment_Homo sapiens_hsa047132.50484689
14Circadian rhythm_Homo sapiens_hsa047102.47828951
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41729289
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39130484
17Glutamatergic synapse_Homo sapiens_hsa047242.28357023
18mTOR signaling pathway_Homo sapiens_hsa041502.25463208
19Dopaminergic synapse_Homo sapiens_hsa047282.23281248
20Cocaine addiction_Homo sapiens_hsa050302.22315700
21Hedgehog signaling pathway_Homo sapiens_hsa043402.19145341
22Hippo signaling pathway_Homo sapiens_hsa043902.18667176
23Notch signaling pathway_Homo sapiens_hsa043302.11020066
24Arginine and proline metabolism_Homo sapiens_hsa003302.04176436
25Nucleotide excision repair_Homo sapiens_hsa034202.02571952
26mRNA surveillance pathway_Homo sapiens_hsa030151.91079194
27Long-term potentiation_Homo sapiens_hsa047201.90927476
28Adherens junction_Homo sapiens_hsa045201.86504538
29Oxidative phosphorylation_Homo sapiens_hsa001901.81351193
30Butanoate metabolism_Homo sapiens_hsa006501.73509924
31Renin secretion_Homo sapiens_hsa049241.70815585
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68739751
33Fanconi anemia pathway_Homo sapiens_hsa034601.65398146
34Phototransduction_Homo sapiens_hsa047441.64516602
35RNA transport_Homo sapiens_hsa030131.63371118
36Serotonergic synapse_Homo sapiens_hsa047261.62064667
37p53 signaling pathway_Homo sapiens_hsa041151.59083225
38Long-term depression_Homo sapiens_hsa047301.56869428
39TGF-beta signaling pathway_Homo sapiens_hsa043501.55549798
40Homologous recombination_Homo sapiens_hsa034401.55203276
41Fatty acid metabolism_Homo sapiens_hsa012121.53527683
42Salivary secretion_Homo sapiens_hsa049701.52868303
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.52862641
44Spliceosome_Homo sapiens_hsa030401.52311035
45Cholinergic synapse_Homo sapiens_hsa047251.51653574
46Collecting duct acid secretion_Homo sapiens_hsa049661.48870170
47Gastric acid secretion_Homo sapiens_hsa049711.47764922
48Cardiac muscle contraction_Homo sapiens_hsa042601.46328578
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45661323
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45032448
51Biosynthesis of amino acids_Homo sapiens_hsa012301.41147633
52Sulfur relay system_Homo sapiens_hsa041221.39387976
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38871844
54Wnt signaling pathway_Homo sapiens_hsa043101.37095175
55Parkinsons disease_Homo sapiens_hsa050121.36672934
56Bladder cancer_Homo sapiens_hsa052191.35964329
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33961625
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33425724
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33371554
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32821682
61Taste transduction_Homo sapiens_hsa047421.30195635
62Lysine degradation_Homo sapiens_hsa003101.29778828
63Basal cell carcinoma_Homo sapiens_hsa052171.29252815
64cAMP signaling pathway_Homo sapiens_hsa040241.29045671
65Cell cycle_Homo sapiens_hsa041101.27352187
66VEGF signaling pathway_Homo sapiens_hsa043701.24475626
67Alzheimers disease_Homo sapiens_hsa050101.23349680
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20970398
69Oxytocin signaling pathway_Homo sapiens_hsa049211.19392886
70Shigellosis_Homo sapiens_hsa051311.19180953
71Calcium signaling pathway_Homo sapiens_hsa040201.17056262
72Folate biosynthesis_Homo sapiens_hsa007901.14504787
73Oocyte meiosis_Homo sapiens_hsa041141.12522834
74Dorso-ventral axis formation_Homo sapiens_hsa043201.08800717
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08016225
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05241917
77Maturity onset diabetes of the young_Homo sapiens_hsa049501.01996494
78Colorectal cancer_Homo sapiens_hsa052101.00895155
79Olfactory transduction_Homo sapiens_hsa047400.96530624
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94834900
81Arginine biosynthesis_Homo sapiens_hsa002200.93794389
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91575020
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88459045
84Propanoate metabolism_Homo sapiens_hsa006400.87893072
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87330384
86Choline metabolism in cancer_Homo sapiens_hsa052310.86698793
87Tight junction_Homo sapiens_hsa045300.84045298
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84035491
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83182722
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.82991538
91Pancreatic secretion_Homo sapiens_hsa049720.80305455
92Type II diabetes mellitus_Homo sapiens_hsa049300.80212126
93MicroRNAs in cancer_Homo sapiens_hsa052060.79459495
94Fructose and mannose metabolism_Homo sapiens_hsa000510.77998116
95beta-Alanine metabolism_Homo sapiens_hsa004100.77292185
96Regulation of autophagy_Homo sapiens_hsa041400.77026339
97Vibrio cholerae infection_Homo sapiens_hsa051100.76828823
98Type I diabetes mellitus_Homo sapiens_hsa049400.75950976
99ErbB signaling pathway_Homo sapiens_hsa040120.75486945
100Protein export_Homo sapiens_hsa030600.75169419
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.73743261
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73247484
103Gap junction_Homo sapiens_hsa045400.72582052
104Melanogenesis_Homo sapiens_hsa049160.72581828
105Ether lipid metabolism_Homo sapiens_hsa005650.67398755
106Primary immunodeficiency_Homo sapiens_hsa053400.67016645
107Thyroid hormone synthesis_Homo sapiens_hsa049180.64264225
108AMPK signaling pathway_Homo sapiens_hsa041520.64108502
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62987632
110Tryptophan metabolism_Homo sapiens_hsa003800.62496720
111Axon guidance_Homo sapiens_hsa043600.61374494
112Huntingtons disease_Homo sapiens_hsa050160.61161994
113Glucagon signaling pathway_Homo sapiens_hsa049220.57889123
114Sphingolipid metabolism_Homo sapiens_hsa006000.57730416
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56962235
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56730202
117Viral myocarditis_Homo sapiens_hsa054160.56231208
118Chronic myeloid leukemia_Homo sapiens_hsa052200.56187356
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55864206
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53136912
121Insulin signaling pathway_Homo sapiens_hsa049100.52599838
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51556025
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51526606
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51381994
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.51179389
126Thyroid cancer_Homo sapiens_hsa052160.50405175
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49421049
128Ovarian steroidogenesis_Homo sapiens_hsa049130.48871214
129Acute myeloid leukemia_Homo sapiens_hsa052210.48727012
130Small cell lung cancer_Homo sapiens_hsa052220.48569233
131Bile secretion_Homo sapiens_hsa049760.46537322
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44825691
133MAPK signaling pathway_Homo sapiens_hsa040100.43108467
134Nitrogen metabolism_Homo sapiens_hsa009100.43043534
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42144041
136Peroxisome_Homo sapiens_hsa041460.42017988
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40896011
138Endometrial cancer_Homo sapiens_hsa052130.40186933
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38222790
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38131272
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37619675
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35783001
143Viral carcinogenesis_Homo sapiens_hsa052030.35459551
144Proteoglycans in cancer_Homo sapiens_hsa052050.35304364
145Glutathione metabolism_Homo sapiens_hsa004800.35276951
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35009690
147Alcoholism_Homo sapiens_hsa050340.34318930
148Steroid biosynthesis_Homo sapiens_hsa001000.33509706
149Pancreatic cancer_Homo sapiens_hsa052120.32249134
150Basal transcription factors_Homo sapiens_hsa030220.31590047
151Ras signaling pathway_Homo sapiens_hsa040140.30904918
152Galactose metabolism_Homo sapiens_hsa000520.30712841
153Histidine metabolism_Homo sapiens_hsa003400.30487462
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29499956
155RNA degradation_Homo sapiens_hsa030180.28863362
156Legionellosis_Homo sapiens_hsa051340.28382868
157PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28204527
158GnRH signaling pathway_Homo sapiens_hsa049120.26739453
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25523683
160Focal adhesion_Homo sapiens_hsa045100.24933891
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.24858869
162Estrogen signaling pathway_Homo sapiens_hsa049150.23419493
163Endocytosis_Homo sapiens_hsa041440.22734023
164Mineral absorption_Homo sapiens_hsa049780.22120945
165Prostate cancer_Homo sapiens_hsa052150.21401767
166Pathways in cancer_Homo sapiens_hsa052000.20930738
167Linoleic acid metabolism_Homo sapiens_hsa005910.18542554
168Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17848667
169HTLV-I infection_Homo sapiens_hsa051660.15697103
170Fatty acid elongation_Homo sapiens_hsa000620.15236803
171Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13555468
172Rap1 signaling pathway_Homo sapiens_hsa040150.13413888
173alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13303699
174Hepatitis B_Homo sapiens_hsa051610.13256860
175Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12227704
176Sphingolipid signaling pathway_Homo sapiens_hsa040710.12123370
177One carbon pool by folate_Homo sapiens_hsa006700.11457606
178Herpes simplex infection_Homo sapiens_hsa051680.10458802

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