DMRTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.57335182
2cellular ketone body metabolic process (GO:0046950)4.22026210
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92185375
4dendritic spine morphogenesis (GO:0060997)3.89917840
5axoneme assembly (GO:0035082)3.79862407
6glutamate secretion (GO:0014047)3.74883129
7ketone body metabolic process (GO:1902224)3.69353283
8transmission of nerve impulse (GO:0019226)3.66466157
9insulin secretion (GO:0030073)3.63273036
10regulation of respiratory system process (GO:0044065)3.59767690
11protein localization to synapse (GO:0035418)3.57459721
12positive regulation of oligodendrocyte differentiation (GO:0048714)3.52357120
13pyrimidine nucleobase catabolic process (GO:0006208)3.52349734
14regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50982578
15protein localization to cilium (GO:0061512)3.47563266
16glycosphingolipid biosynthetic process (GO:0006688)3.45689168
17epithelial cilium movement (GO:0003351)3.40134160
18synaptic vesicle exocytosis (GO:0016079)3.39588497
19platelet dense granule organization (GO:0060155)3.38992155
20intraciliary transport (GO:0042073)3.33932011
21neurotransmitter secretion (GO:0007269)3.30263236
22ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.27825817
23behavioral response to nicotine (GO:0035095)3.23773859
24protein polyglutamylation (GO:0018095)3.19695238
25nucleobase catabolic process (GO:0046113)3.18325281
26ribonucleoprotein complex disassembly (GO:0032988)3.17642202
27signal peptide processing (GO:0006465)3.15123283
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.10578135
29cilium movement (GO:0003341)3.09767816
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.07566985
31spinal cord association neuron differentiation (GO:0021527)3.07001988
32inositol phosphate catabolic process (GO:0071545)3.06227587
33regulation of cilium movement (GO:0003352)3.05925434
34negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05315349
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.02303470
36positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.00917298
37neuron cell-cell adhesion (GO:0007158)2.97820739
38neuron fate determination (GO:0048664)2.96465521
39peptide hormone secretion (GO:0030072)2.94785339
40regulation of synapse structural plasticity (GO:0051823)2.91028603
41brain morphogenesis (GO:0048854)2.89699912
42calcium ion-dependent exocytosis (GO:0017156)2.89402166
43establishment of mitochondrion localization (GO:0051654)2.88890860
44glycerophospholipid catabolic process (GO:0046475)2.88832370
45peptide secretion (GO:0002790)2.85667002
46regulation of respiratory gaseous exchange (GO:0043576)2.84450052
47acrosome reaction (GO:0007340)2.82574123
48regulation of feeding behavior (GO:0060259)2.82186909
49synapse assembly (GO:0007416)2.80740143
50organelle disassembly (GO:1903008)2.80413052
51reflex (GO:0060004)2.80206463
52inositol phosphate dephosphorylation (GO:0046855)2.79932014
53phosphorylated carbohydrate dephosphorylation (GO:0046838)2.79932014
54startle response (GO:0001964)2.79863441
55axonal fasciculation (GO:0007413)2.77533722
56positive regulation of synapse assembly (GO:0051965)2.76885362
57regulation of acrosome reaction (GO:0060046)2.76049907
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72871626
59postsynaptic membrane organization (GO:0001941)2.72506054
60opioid receptor signaling pathway (GO:0038003)2.72130301
61cardiac left ventricle morphogenesis (GO:0003214)2.72031772
62cilium or flagellum-dependent cell motility (GO:0001539)2.72000811
63nonmotile primary cilium assembly (GO:0035058)2.69704295
64neuron-neuron synaptic transmission (GO:0007270)2.69626311
65regulation of neurotransmitter levels (GO:0001505)2.68553723
66regulation of calcium ion-dependent exocytosis (GO:0017158)2.65741207
67neurotransmitter catabolic process (GO:0042135)2.65675169
68regulation of synaptic vesicle exocytosis (GO:2000300)2.65483221
69regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64289162
70positive regulation of insulin secretion (GO:0032024)2.63989529
71synaptic transmission, glutamatergic (GO:0035249)2.63708356
72regulation of microtubule-based movement (GO:0060632)2.62616943
73glucosamine-containing compound catabolic process (GO:1901072)2.62351922
74signal release (GO:0023061)2.61603534
75locomotory exploration behavior (GO:0035641)2.61511871
76neuron recognition (GO:0008038)2.60989047
77retinal ganglion cell axon guidance (GO:0031290)2.60894115
78regulation of vesicle fusion (GO:0031338)2.60572667
79microtubule severing (GO:0051013)2.59179923
80indole-containing compound catabolic process (GO:0042436)2.59126518
81indolalkylamine catabolic process (GO:0046218)2.59126518
82tryptophan catabolic process (GO:0006569)2.59126518
83membrane hyperpolarization (GO:0060081)2.58631830
84auditory receptor cell differentiation (GO:0042491)2.58571264
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57673298
86DNA damage response, detection of DNA damage (GO:0042769)2.56754236
87NAD biosynthetic process (GO:0009435)2.56528207
88protein complex biogenesis (GO:0070271)2.55994319
89mitochondrial calcium ion homeostasis (GO:0051560)2.51420857
90cilium morphogenesis (GO:0060271)2.51146045
91neuromuscular synaptic transmission (GO:0007274)2.50984210
92positive regulation of peptide hormone secretion (GO:0090277)2.50202515
93proline transport (GO:0015824)2.49847717
94auditory behavior (GO:0031223)2.48447148
95neuronal action potential propagation (GO:0019227)2.47301501
96dendritic spine organization (GO:0097061)2.46804330
97neurotransmitter transport (GO:0006836)2.46598251
98calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46267656
99sperm motility (GO:0030317)2.45848326
100positive regulation of peptide secretion (GO:0002793)2.45552945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.52847073
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.70441070
3ZNF274_21170338_ChIP-Seq_K562_Hela2.74075107
4GBX2_23144817_ChIP-Seq_PC3_Human2.70590324
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63171046
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48916412
7IGF1R_20145208_ChIP-Seq_DFB_Human2.45238171
8REST_21632747_ChIP-Seq_MESCs_Mouse2.41184273
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35359200
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27022151
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19662151
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.14893124
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11152192
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01841305
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01363043
16TAF15_26573619_Chip-Seq_HEK293_Human1.99376556
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85780613
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.85252041
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78850273
20RNF2_27304074_Chip-Seq_NSC_Mouse1.78224690
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77858608
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.76936202
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76735780
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76673434
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73874006
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71308087
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66271561
28ETV2_25802403_ChIP-Seq_MESCs_Mouse1.60870720
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57672853
30P300_19829295_ChIP-Seq_ESCs_Human1.53470673
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50090188
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.42538595
33VDR_22108803_ChIP-Seq_LS180_Human1.41464891
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.41281522
35FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40852431
36FUS_26573619_Chip-Seq_HEK293_Human1.39986436
37TP53_22573176_ChIP-Seq_HFKS_Human1.38622321
38* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38425434
39SMAD4_21799915_ChIP-Seq_A2780_Human1.36282984
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35060341
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31864211
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.31018487
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29510814
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25395597
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24496586
46DROSHA_22980978_ChIP-Seq_HELA_Human1.22722874
47AR_25329375_ChIP-Seq_VCAP_Human1.22416862
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22412198
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21168092
50TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19270239
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18956257
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17950763
53TAL1_26923725_Chip-Seq_HPCs_Mouse1.16060042
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15648946
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15648946
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15040454
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15014474
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11709312
59CBP_20019798_ChIP-Seq_JUKART_Human1.11709312
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11701003
61TCF4_23295773_ChIP-Seq_U87_Human1.10764373
62STAT3_23295773_ChIP-Seq_U87_Human1.10670067
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09438064
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09350381
65ER_23166858_ChIP-Seq_MCF-7_Human1.08274052
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07169789
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06726445
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06265657
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04741341
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03852002
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01362207
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.01048743
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00920243
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.00560294
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00075741
76HTT_18923047_ChIP-ChIP_STHdh_Human0.98497051
77GATA3_21878914_ChIP-Seq_MCF-7_Human0.98383043
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97888034
79TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97669603
80JUN_21703547_ChIP-Seq_K562_Human0.97555334
81FOXA1_25329375_ChIP-Seq_VCAP_Human0.94716263
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94716263
83NCOR_22424771_ChIP-Seq_293T_Human0.94325530
84RUNX2_22187159_ChIP-Seq_PCA_Human0.94323062
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93821350
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93755285
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93741706
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.92925701
89TCF4_22108803_ChIP-Seq_LS180_Human0.92361993
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91745607
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.91081479
92RNF2_27304074_Chip-Seq_ESCs_Mouse0.90548191
93BCAT_22108803_ChIP-Seq_LS180_Human0.90411259
94IRF1_19129219_ChIP-ChIP_H3396_Human0.89366057
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.88682392
96AR_21572438_ChIP-Seq_LNCaP_Human0.88157541
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87620253
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86504528
99RARB_27405468_Chip-Seq_BRAIN_Mouse0.85916730
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.85240547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland3.34546143
2MP0002102_abnormal_ear_morphology3.29047697
3MP0003122_maternal_imprinting3.09114354
4MP0002837_dystrophic_cardiac_calcinosis2.99313257
5MP0003787_abnormal_imprinting2.84411123
6MP0003880_abnormal_central_pattern2.68544197
7MP0001968_abnormal_touch/_nociception2.51502324
8MP0006276_abnormal_autonomic_nervous2.48807500
9MP0005645_abnormal_hypothalamus_physiol2.34608984
10MP0004147_increased_porphyrin_level2.29273556
11MP0009046_muscle_twitch2.28577248
12MP0002653_abnormal_ependyma_morphology2.20087167
13MP0003121_genomic_imprinting2.14701293
14MP0002272_abnormal_nervous_system2.11528633
15MP0003635_abnormal_synaptic_transmissio2.09654574
16MP0004270_analgesia1.97946070
17MP0004859_abnormal_synaptic_plasticity1.97046556
18MP0009745_abnormal_behavioral_response1.92380208
19MP0002735_abnormal_chemical_nociception1.92379650
20MP0002734_abnormal_mechanical_nocicepti1.89830088
21MP0001486_abnormal_startle_reflex1.89277430
22MP0002822_catalepsy1.89181584
23MP0001970_abnormal_pain_threshold1.87015581
24MP0008877_abnormal_DNA_methylation1.86156267
25MP0004142_abnormal_muscle_tone1.86018844
26MP0005551_abnormal_eye_electrophysiolog1.85937267
27MP0002733_abnormal_thermal_nociception1.79724881
28MP0002064_seizures1.79025453
29MP0002736_abnormal_nociception_after1.78833341
30MP0001501_abnormal_sleep_pattern1.74533057
31MP0002557_abnormal_social/conspecific_i1.72515196
32MP0006292_abnormal_olfactory_placode1.72417337
33MP0002572_abnormal_emotion/affect_behav1.71739744
34MP0006072_abnormal_retinal_apoptosis1.66357877
35MP0000778_abnormal_nervous_system1.66121024
36MP0002063_abnormal_learning/memory/cond1.65221975
37MP0005423_abnormal_somatic_nervous1.61705640
38MP0002638_abnormal_pupillary_reflex1.56230670
39MP0001984_abnormal_olfaction1.55952192
40MP0005084_abnormal_gallbladder_morpholo1.54087424
41MP0002254_reproductive_system_inflammat1.52606086
42MP0001905_abnormal_dopamine_level1.50561416
43MP0002184_abnormal_innervation1.42485444
44MP0005394_taste/olfaction_phenotype1.42362132
45MP0005499_abnormal_olfactory_system1.42362132
46MP0002067_abnormal_sensory_capabilities1.41838604
47MP0005379_endocrine/exocrine_gland_phen1.41798857
48MP0009780_abnormal_chondrocyte_physiolo1.40420276
49MP0002139_abnormal_hepatobiliary_system1.39827634
50MP0004133_heterotaxia1.35510672
51MP0002163_abnormal_gland_morphology1.33186790
52MP0003195_calcinosis1.31973108
53MP0000955_abnormal_spinal_cord1.31040295
54MP0004742_abnormal_vestibular_system1.26271482
55MP0005646_abnormal_pituitary_gland1.26227169
56MP0000631_abnormal_neuroendocrine_gland1.24952337
57MP0005248_abnormal_Harderian_gland1.24368297
58MP0005410_abnormal_fertilization1.18355890
59MP0008872_abnormal_physiological_respon1.17372264
60MP0003646_muscle_fatigue1.15844068
61MP0002882_abnormal_neuron_morphology1.15311473
62MP0000566_synostosis1.15108657
63MP0002928_abnormal_bile_duct1.13595207
64MP0002693_abnormal_pancreas_physiology1.13309658
65MP0004885_abnormal_endolymph1.12940983
66MP0005253_abnormal_eye_physiology1.11652528
67MP0004811_abnormal_neuron_physiology1.11482679
68MP0008789_abnormal_olfactory_epithelium1.11397185
69MP0000427_abnormal_hair_cycle1.11283373
70MP0005377_hearing/vestibular/ear_phenot1.11003076
71MP0003878_abnormal_ear_physiology1.11003076
72MP0001529_abnormal_vocalization1.09558211
73MP0002751_abnormal_autonomic_nervous1.07276508
74MP0001502_abnormal_circadian_rhythm1.04399508
75MP0003123_paternal_imprinting1.03471080
76MP0002752_abnormal_somatic_nervous1.03279472
77MP0002069_abnormal_eating/drinking_beha1.02759454
78MP0004924_abnormal_behavior1.01294834
79MP0005386_behavior/neurological_phenoty1.01294834
80MP0001986_abnormal_taste_sensitivity1.01104535
81MP0002876_abnormal_thyroid_physiology0.99995718
82MP0000013_abnormal_adipose_tissue0.99799251
83MP0005448_abnormal_energy_balance0.97396625
84MP0002066_abnormal_motor_capabilities/c0.96776091
85MP0001963_abnormal_hearing_physiology0.94955354
86MP0001944_abnormal_pancreas_morphology0.91615684
87MP0010386_abnormal_urinary_bladder0.89359311
88MP0002229_neurodegeneration0.89352255
89MP0005167_abnormal_blood-brain_barrier0.87370287
90MP0008995_early_reproductive_senescence0.86551918
91MP0001485_abnormal_pinna_reflex0.86546740
92MP0001188_hyperpigmentation0.85756837
93MP0005332_abnormal_amino_acid0.84957996
94MP0004145_abnormal_muscle_electrophysio0.84422972
95MP0001440_abnormal_grooming_behavior0.83120823
96MP0001919_abnormal_reproductive_system0.82302475
97MP0000026_abnormal_inner_ear0.80874010
98MP0002938_white_spotting0.80323419
99MP0000639_abnormal_adrenal_gland0.76797925
100MP0002078_abnormal_glucose_homeostasis0.76552019

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.05906575
2Methylmalonic acidemia (HP:0002912)3.53818897
3Focal motor seizures (HP:0011153)3.51125601
4Polyphagia (HP:0002591)3.45032219
5Methylmalonic aciduria (HP:0012120)3.41963785
6Pancreatic cysts (HP:0001737)2.94280836
7Hypothermia (HP:0002045)2.89961921
8Abnormality of midbrain morphology (HP:0002418)2.89460519
9Molar tooth sign on MRI (HP:0002419)2.89460519
10Medial flaring of the eyebrow (HP:0010747)2.86174142
11Pancreatic fibrosis (HP:0100732)2.81498486
12True hermaphroditism (HP:0010459)2.75816927
13Progressive cerebellar ataxia (HP:0002073)2.74126899
14Ketoacidosis (HP:0001993)2.71579941
15Polydipsia (HP:0001959)2.68549256
16Abnormal drinking behavior (HP:0030082)2.68549256
17Lipid accumulation in hepatocytes (HP:0006561)2.67894955
18Dialeptic seizures (HP:0011146)2.66268518
19Increased hepatocellular lipid droplets (HP:0006565)2.63801446
20Retinal dysplasia (HP:0007973)2.53104727
21Abnormality of the labia minora (HP:0012880)2.50411109
22Abnormal hair whorl (HP:0010721)2.46600275
23Congenital stationary night blindness (HP:0007642)2.43987422
24Mitochondrial inheritance (HP:0001427)2.43443208
25Oligodactyly (hands) (HP:0001180)2.43427300
26Neonatal respiratory distress (HP:0002643)2.40792685
27Abnormal eating behavior (HP:0100738)2.40052613
28Gait imbalance (HP:0002141)2.37864397
29Agitation (HP:0000713)2.37558992
30Focal seizures (HP:0007359)2.36970135
31Nephronophthisis (HP:0000090)2.35630138
32Severe visual impairment (HP:0001141)2.34381664
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34079127
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34079127
35Hypsarrhythmia (HP:0002521)2.31504832
36Epileptiform EEG discharges (HP:0011182)2.31001216
37EEG with generalized epileptiform discharges (HP:0011198)2.29741713
38Amblyopia (HP:0000646)2.29699808
39Absence seizures (HP:0002121)2.29353919
40Hepatocellular necrosis (HP:0001404)2.27810988
41Polyuria (HP:0000103)2.22367334
42Muscular hypotonia of the trunk (HP:0008936)2.21714089
43Abnormal pancreas size (HP:0012094)2.21648843
44Abnormality of vitamin B metabolism (HP:0004340)2.21400646
45Tubular atrophy (HP:0000092)2.19399881
46Hepatic necrosis (HP:0002605)2.19204739
47Abnormality of macular pigmentation (HP:0008002)2.17940208
48Type II lissencephaly (HP:0007260)2.17454923
49Hemiparesis (HP:0001269)2.16902781
50Febrile seizures (HP:0002373)2.15905992
51Cystic liver disease (HP:0006706)2.15639007
52Colon cancer (HP:0003003)2.15423120
53Oligodactyly (HP:0012165)2.15204760
54Intention tremor (HP:0002080)2.14720508
55Aplasia/hypoplasia of the uterus (HP:0008684)2.14564431
56Spastic gait (HP:0002064)2.14484989
57Broad-based gait (HP:0002136)2.14140018
58Lissencephaly (HP:0001339)2.12293916
59Congenital primary aphakia (HP:0007707)2.11799906
60Action tremor (HP:0002345)2.11014225
61Acute necrotizing encephalopathy (HP:0006965)2.10526010
62Hyperventilation (HP:0002883)2.10457359
63Renal Fanconi syndrome (HP:0001994)2.09554476
64Drooling (HP:0002307)2.07596713
65Status epilepticus (HP:0002133)2.07491669
66Atonic seizures (HP:0010819)2.06586406
67Nephrogenic diabetes insipidus (HP:0009806)2.06187868
68CNS hypomyelination (HP:0003429)2.05537748
69Pendular nystagmus (HP:0012043)2.04814356
70Ankle clonus (HP:0011448)2.04143162
71Generalized tonic-clonic seizures (HP:0002069)2.03522737
72Limb dystonia (HP:0002451)2.02380805
73Abnormality of the renal medulla (HP:0100957)2.02297730
74Hypomagnesemia (HP:0002917)2.01685336
75Abnormality of urine glucose concentration (HP:0011016)2.01274334
76Glycosuria (HP:0003076)2.01274334
77Increased CSF lactate (HP:0002490)1.95508582
78Ketosis (HP:0001946)1.94905703
79Abnormal mitochondria in muscle tissue (HP:0008316)1.94508056
80Increased intramyocellular lipid droplets (HP:0012240)1.93108617
81Failure to thrive in infancy (HP:0001531)1.93107711
82Cerebellar dysplasia (HP:0007033)1.92167823
83Hypoalbuminemia (HP:0003073)1.92159504
84Abnormal albumin level (HP:0012116)1.92159504
85Excessive salivation (HP:0003781)1.91803814
86Hyperinsulinemic hypoglycemia (HP:0000825)1.89737344
87Abnormal ciliary motility (HP:0012262)1.87976033
88Abnormal respiratory motile cilium morphology (HP:0005938)1.86937135
89Abnormal respiratory epithelium morphology (HP:0012253)1.86937135
90Exertional dyspnea (HP:0002875)1.86229348
91Abnormality of the renal cortex (HP:0011035)1.85339423
92Large for gestational age (HP:0001520)1.83916347
93Congenital malformation of the right heart (HP:0011723)1.81644119
94Double outlet right ventricle (HP:0001719)1.81644119
95Abnormal urine output (HP:0012590)1.81409466
96Sclerocornea (HP:0000647)1.80456169
97Pachygyria (HP:0001302)1.79727663
98Genital tract atresia (HP:0001827)1.78916976
99Abnormality of the corticospinal tract (HP:0002492)1.78730642
100Papilledema (HP:0001085)1.78554683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.53203746
2MAP4K23.25809267
3MAP3K42.70775748
4PINK12.57013238
5WNK32.22152761
6DAPK22.19486502
7MAP3K92.18382831
8STK162.12144430
9MAP3K122.07193374
10FRK2.04350690
11GRK11.85016389
12CASK1.82827640
13TRIM281.82572017
14SIK21.80658654
15MAPK131.78021470
16MINK11.68156000
17PAK31.61945465
18WNK41.56395909
19CSNK1G31.55799534
20ADRBK21.55517687
21CSNK1G21.53720030
22NTRK21.46512072
23OXSR11.46218281
24NTRK31.46017574
25MAP2K71.44334036
26GRK71.41962659
27BCR1.41001390
28PRKCG1.38689897
29PLK21.37889718
30PHKG11.37789257
31PHKG21.37789257
32UHMK11.34083991
33MAP3K111.32442249
34CSNK1G11.28976881
35MAP2K41.28715183
36TXK1.28276010
37DYRK21.28168232
38STK391.22736763
39CSNK1A1L1.21637968
40TNK21.20701984
41PRKCE1.14559397
42PASK1.13676390
43TYRO31.07871162
44SIK31.06883448
45CAMKK21.06369429
46FGFR21.05974023
47CAMKK11.01939290
48DYRK30.98600738
49EPHA40.95895345
50GRK50.88056619
51DYRK1B0.87897522
52BCKDK0.87690534
53LATS10.85810045
54BMPR1B0.85650523
55ZAK0.85431487
56DYRK1A0.85027861
57INSRR0.83670540
58MAP2K60.80348279
59PAK60.79589460
60STK38L0.77854668
61KSR10.74701166
62ADRBK10.73108535
63EPHB20.71979080
64CAMK2A0.71905908
65CDK190.65894487
66CDK50.62750780
67PRKG10.60568773
68PRKACA0.60520407
69TAOK30.59973734
70NUAK10.59947596
71CAMK2D0.58263415
72DAPK10.58204178
73CAMK10.57579187
74ITK0.56381048
75STK380.54414875
76ARAF0.52482183
77MAP3K50.50876894
78STK110.49932149
79CAMK2B0.48288509
80MARK20.46795277
81IRAK40.46734268
82CDK140.46645955
83CSNK1A10.46604643
84PRKAA10.45683830
85SGK2230.44061511
86SGK4940.44061511
87PRKCA0.43859807
88TAOK10.43104196
89PRKCZ0.42904141
90MAP4K10.40423344
91FYN0.39486210
92IKBKE0.38746943
93ERBB20.37811194
94CDK180.37596751
95CSNK1D0.37319562
96CDK11A0.37076461
97MUSK0.35418891
98TIE10.35054136
99CDK150.34313665
100PRKCB0.33431256

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66262716
2Nicotine addiction_Homo sapiens_hsa050333.28958245
3Oxidative phosphorylation_Homo sapiens_hsa001902.88301650
4Protein export_Homo sapiens_hsa030602.79800312
5Butanoate metabolism_Homo sapiens_hsa006502.65232741
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.51350167
7Insulin secretion_Homo sapiens_hsa049112.48034986
8GABAergic synapse_Homo sapiens_hsa047272.38274778
9Parkinsons disease_Homo sapiens_hsa050122.34144930
10Morphine addiction_Homo sapiens_hsa050322.32726913
11Synaptic vesicle cycle_Homo sapiens_hsa047212.25364651
12Phototransduction_Homo sapiens_hsa047442.10899539
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06903998
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05750037
15Collecting duct acid secretion_Homo sapiens_hsa049661.92552830
16Circadian entrainment_Homo sapiens_hsa047131.92463151
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.78303577
18Glutamatergic synapse_Homo sapiens_hsa047241.72409833
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72217188
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65845427
21Propanoate metabolism_Homo sapiens_hsa006401.63605065
22Cardiac muscle contraction_Homo sapiens_hsa042601.62489854
23Regulation of autophagy_Homo sapiens_hsa041401.56870005
24Dopaminergic synapse_Homo sapiens_hsa047281.55233942
25Alzheimers disease_Homo sapiens_hsa050101.53656036
26Fatty acid elongation_Homo sapiens_hsa000621.51310750
27Serotonergic synapse_Homo sapiens_hsa047261.42720084
28Taste transduction_Homo sapiens_hsa047421.42574758
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35605366
30Amphetamine addiction_Homo sapiens_hsa050311.34916001
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.34594899
32Type I diabetes mellitus_Homo sapiens_hsa049401.31750224
33Cocaine addiction_Homo sapiens_hsa050301.31239985
34Huntingtons disease_Homo sapiens_hsa050161.24374243
35Salivary secretion_Homo sapiens_hsa049701.22970613
36Tryptophan metabolism_Homo sapiens_hsa003801.18089268
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08927715
38Linoleic acid metabolism_Homo sapiens_hsa005911.07590303
39Long-term depression_Homo sapiens_hsa047301.06449446
40Peroxisome_Homo sapiens_hsa041461.06050254
41Renin secretion_Homo sapiens_hsa049241.02014163
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01670226
43Olfactory transduction_Homo sapiens_hsa047401.00988354
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99926644
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99256379
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97253952
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96188094
48beta-Alanine metabolism_Homo sapiens_hsa004100.95882745
49Vibrio cholerae infection_Homo sapiens_hsa051100.93330287
50Folate biosynthesis_Homo sapiens_hsa007900.90677002
51Gastric acid secretion_Homo sapiens_hsa049710.90216346
52Cholinergic synapse_Homo sapiens_hsa047250.90080649
53Ether lipid metabolism_Homo sapiens_hsa005650.89083664
54cAMP signaling pathway_Homo sapiens_hsa040240.83326526
55Ovarian steroidogenesis_Homo sapiens_hsa049130.81572213
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77764052
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76370225
58Oocyte meiosis_Homo sapiens_hsa041140.70189537
59Oxytocin signaling pathway_Homo sapiens_hsa049210.69089851
60Mineral absorption_Homo sapiens_hsa049780.67979275
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67327985
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64653718
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63538217
64Sphingolipid metabolism_Homo sapiens_hsa006000.61536295
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.60604635
66Calcium signaling pathway_Homo sapiens_hsa040200.59114486
67Selenocompound metabolism_Homo sapiens_hsa004500.58031517
68Hedgehog signaling pathway_Homo sapiens_hsa043400.53372301
69Type II diabetes mellitus_Homo sapiens_hsa049300.52894260
70Fatty acid metabolism_Homo sapiens_hsa012120.52665504
71Metabolic pathways_Homo sapiens_hsa011000.50182583
72Arginine and proline metabolism_Homo sapiens_hsa003300.49415311
73Axon guidance_Homo sapiens_hsa043600.48638631
74Nitrogen metabolism_Homo sapiens_hsa009100.46205777
75Basal transcription factors_Homo sapiens_hsa030220.45638405
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45564865
77Pancreatic secretion_Homo sapiens_hsa049720.44809289
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44558162
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.43363546
80Gap junction_Homo sapiens_hsa045400.42918247
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40363469
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39792959
83Circadian rhythm_Homo sapiens_hsa047100.36372691
84Arachidonic acid metabolism_Homo sapiens_hsa005900.34851772
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33865622
86Asthma_Homo sapiens_hsa053100.33821087
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33505976
88Long-term potentiation_Homo sapiens_hsa047200.32408284
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31288212
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.30437817
91Basal cell carcinoma_Homo sapiens_hsa052170.29631458
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.28414834
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27772464
94Alcoholism_Homo sapiens_hsa050340.27392039
95Melanogenesis_Homo sapiens_hsa049160.27312205
96Rheumatoid arthritis_Homo sapiens_hsa053230.26963307
97Thyroid hormone synthesis_Homo sapiens_hsa049180.26615584
98Dorso-ventral axis formation_Homo sapiens_hsa043200.26357823
99Glucagon signaling pathway_Homo sapiens_hsa049220.26166118
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25087244

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