DMRTB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.91538819
2sperm-egg recognition (GO:0035036)9.66897520
3cilium or flagellum-dependent cell motility (GO:0001539)9.63380249
4spermatid development (GO:0007286)9.48673983
5acrosome assembly (GO:0001675)9.30875274
6cell wall macromolecule catabolic process (GO:0016998)9.10446624
7cell wall macromolecule metabolic process (GO:0044036)9.10446624
8binding of sperm to zona pellucida (GO:0007339)8.97924899
9axonemal dynein complex assembly (GO:0070286)8.78877041
10multicellular organism reproduction (GO:0032504)8.78772384
11cell-cell recognition (GO:0009988)8.58764678
12plasma membrane fusion (GO:0045026)8.32453324
13cilium movement (GO:0003341)7.96767141
14regulation of cilium movement (GO:0003352)7.85224939
15motile cilium assembly (GO:0044458)7.82510536
16male meiosis (GO:0007140)7.81537368
17synaptonemal complex organization (GO:0070193)7.64537550
18DNA methylation involved in gamete generation (GO:0043046)7.51201253
19synaptonemal complex assembly (GO:0007130)7.48124138
20DNA synthesis involved in DNA repair (GO:0000731)7.46011650
21reproduction (GO:0000003)7.34604634
22male meiosis I (GO:0007141)6.61766899
23regulation of DNA methylation (GO:0044030)6.60207931
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.46112760
25ventricular system development (GO:0021591)6.34105140
26negative regulation of inclusion body assembly (GO:0090084)6.26855285
27seminiferous tubule development (GO:0072520)6.17417246
28arginine catabolic process (GO:0006527)6.13508532
29regulation of female gonad development (GO:2000194)6.13293447
30spermatogenesis (GO:0007283)6.10023064
31female gamete generation (GO:0007292)6.08853735
32male gamete generation (GO:0048232)6.07786725
33single fertilization (GO:0007338)6.06602671
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.02739281
35regulation of histone H3-K9 methylation (GO:0051570)5.99723825
36sister chromatid cohesion (GO:0007062)5.83009258
37regulation of acrosome reaction (GO:0060046)5.64352447
38gamete generation (GO:0007276)5.59145255
39sperm capacitation (GO:0048240)5.58831751
40germ cell development (GO:0007281)5.55822125
41fertilization (GO:0009566)5.44519754
42meiosis I (GO:0007127)5.39046983
43meiotic nuclear division (GO:0007126)5.27141189
44microtubule depolymerization (GO:0007019)5.20889883
45protein localization to cilium (GO:0061512)5.18328552
46cellular process involved in reproduction in multicellular organism (GO:0022412)5.15724356
47regulation of retinoic acid receptor signaling pathway (GO:0048385)5.15328506
48organic cation transport (GO:0015695)5.10328860
49regulation of inclusion body assembly (GO:0090083)5.07034973
50histone H3-K9 demethylation (GO:0033169)5.04929618
51chromosome organization involved in meiosis (GO:0070192)5.03040200
52mitotic chromosome condensation (GO:0007076)4.97354112
53oocyte development (GO:0048599)4.89653713
54regulation of microtubule-based movement (GO:0060632)4.70791202
55regulation of meiotic cell cycle (GO:0051445)4.68787851
56positive regulation of meiosis (GO:0045836)4.59016748
57attachment of spindle microtubules to kinetochore (GO:0008608)4.49339013
58calcium ion-dependent exocytosis (GO:0017156)4.43733352
59spermatid nucleus differentiation (GO:0007289)4.40600208
60cell recognition (GO:0008037)4.38673369
61multicellular organismal reproductive process (GO:0048609)4.35356959
62resolution of meiotic recombination intermediates (GO:0000712)4.34155740
63positive regulation of meiotic cell cycle (GO:0051446)4.33796402
64reciprocal meiotic recombination (GO:0007131)4.31734634
65reciprocal DNA recombination (GO:0035825)4.31734634
66regulation of meiosis (GO:0040020)4.31140872
67chromosome condensation (GO:0030261)4.25073893
68regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.18380756
69cilium morphogenesis (GO:0060271)4.15281595
70mitochondrial fusion (GO:0008053)4.14366948
71histone exchange (GO:0043486)4.13100645
72DNA packaging (GO:0006323)4.12678294
73meiotic chromosome segregation (GO:0045132)4.11763131
74negative regulation of reproductive process (GO:2000242)4.00846304
75chaperone-mediated protein complex assembly (GO:0051131)3.99536862
76protein localization to chromosome (GO:0034502)3.99193040
77mitotic metaphase plate congression (GO:0007080)3.98729935
78microtubule severing (GO:0051013)3.94964995
79oogenesis (GO:0048477)3.93671991
80meiotic cell cycle (GO:0051321)3.91553966
81retinal cone cell development (GO:0046549)3.87345115
82citrulline metabolic process (GO:0000052)3.86583397
83regulation of protein kinase C signaling (GO:0090036)3.86321978
84positive regulation of histone H3-K4 methylation (GO:0051571)3.82701514
85sequestering of actin monomers (GO:0042989)3.77019237
86negative regulation of histone methylation (GO:0031061)3.73947636
87protein localization to chromosome, centromeric region (GO:0071459)3.70439112
88CENP-A containing nucleosome assembly (GO:0034080)3.68291695
89regulation of meiosis I (GO:0060631)3.68231422
90left/right pattern formation (GO:0060972)3.58314730
91centriole replication (GO:0007099)3.57101357
92arginine metabolic process (GO:0006525)3.57030868
93protein kinase C signaling (GO:0070528)3.54852262
94histone H3-K36 demethylation (GO:0070544)3.49606715
95mitochondrial fission (GO:0000266)3.45505338
96meiotic cell cycle process (GO:1903046)3.45027744
97negative regulation of gene silencing (GO:0060969)3.44813542
98positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44573619
99positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44573619
100positive regulation of mitotic sister chromatid separation (GO:1901970)3.44573619
101chromatin remodeling at centromere (GO:0031055)3.43572613
102gene silencing by RNA (GO:0031047)3.43119299
103protein localization to kinetochore (GO:0034501)3.42058330
104multicellular organismal development (GO:0007275)3.38335915
105negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.37157834
106DNA biosynthetic process (GO:0071897)3.34969254
107glycine transport (GO:0015816)3.33348589
108positive regulation of histone methylation (GO:0031062)3.29856630
109metaphase plate congression (GO:0051310)3.27758789
110genitalia morphogenesis (GO:0035112)3.26541838
111positive regulation of chromosome segregation (GO:0051984)3.26169539
112proteasome assembly (GO:0043248)3.24638465
113DNA replication-dependent nucleosome organization (GO:0034723)3.19496174
114DNA replication-dependent nucleosome assembly (GO:0006335)3.19496174
115DNA methylation or demethylation (GO:0044728)3.19126080
116regulation of steroid hormone secretion (GO:2000831)3.18477238
117monoubiquitinated protein deubiquitination (GO:0035520)3.18248131
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17796519
119chromosome organization (GO:0051276)3.17007972
120female gonad development (GO:0008585)3.16025260
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15535283
122glycerol ether metabolic process (GO:0006662)3.15158231
123alditol metabolic process (GO:0019400)3.14011795
124interkinetic nuclear migration (GO:0022027)3.13300839
125regulation of spindle checkpoint (GO:0090231)3.12560418
126regulation of chromatin silencing (GO:0031935)3.12507792
127hyperosmotic salinity response (GO:0042538)3.12211401
128negative regulation of meiosis (GO:0045835)3.08172415
129microtubule-based movement (GO:0007018)3.05634805
130nitric oxide biosynthetic process (GO:0006809)3.04583059
131establishment of chromosome localization (GO:0051303)3.04475629
132regulation of histone methylation (GO:0031060)3.02440805
133regulation of cell maturation (GO:1903429)3.02354666
134protein polyglutamylation (GO:0018095)3.01397321
135positive regulation of humoral immune response (GO:0002922)3.01324616
136nucleus organization (GO:0006997)2.98213685
137regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)2.97675596
138oocyte maturation (GO:0001556)2.95147714
139DNA replication-independent nucleosome assembly (GO:0006336)2.94558713
140DNA replication-independent nucleosome organization (GO:0034724)2.94558713
141cardiovascular system development (GO:0072358)2.93552691
142regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.91282910
143DNA alkylation (GO:0006305)2.90758710
144DNA methylation (GO:0006306)2.90758710
145histone lysine demethylation (GO:0070076)2.90227046
146ether metabolic process (GO:0018904)2.90131234
147synapsis (GO:0007129)2.90076125
148regulation of ruffle assembly (GO:1900027)2.89854344
149negative regulation of organelle assembly (GO:1902116)2.89463270
150regulation of female receptivity (GO:0045924)2.88574499
151protein refolding (GO:0042026)2.78061462
152gene silencing (GO:0016458)2.76689119
153carnitine transport (GO:0015879)2.75900276
154amino-acid betaine transport (GO:0015838)2.75900276
155glycerol metabolic process (GO:0006071)2.75715598
156carnitine transmembrane transport (GO:1902603)2.66709585
157microtubule polymerization or depolymerization (GO:0031109)2.65237186
158nucleoside diphosphate phosphorylation (GO:0006165)2.62581738
159cilium organization (GO:0044782)2.62373981
160mitotic sister chromatid cohesion (GO:0007064)2.61958192
161protein complex localization (GO:0031503)2.61625363
162regulation of ARF GTPase activity (GO:0032312)2.61536720
163nitric oxide mediated signal transduction (GO:0007263)2.60643701
164glutamine family amino acid catabolic process (GO:0009065)2.60230056
165regulation of oxidative phosphorylation (GO:0002082)2.59797601
166sperm motility (GO:0030317)11.9628290
167fusion of sperm to egg plasma membrane (GO:0007342)10.9870609
168piRNA metabolic process (GO:0034587)10.7740435
169acrosome reaction (GO:0007340)10.0054172

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.50845229
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.52561796
3EZH2_22144423_ChIP-Seq_EOC_Human5.49325691
4E2F7_22180533_ChIP-Seq_HELA_Human4.00146962
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77878731
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.67743215
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.40831659
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.40831659
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.40831659
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.62744772
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47821993
12ELK4_26923725_Chip-Seq_MESODERM_Mouse2.33575073
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.31718720
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30694727
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.18946794
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15524834
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14005267
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09365508
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.98048976
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94442788
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.90575682
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89037405
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79421966
24MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.78302843
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73645809
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68423592
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.65828315
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63581217
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62516065
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59726943
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54963828
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54122573
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48927522
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48356286
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.47320919
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.46008250
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44167296
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44091468
39SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40402099
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.38735921
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.38018162
42VDR_22108803_ChIP-Seq_LS180_Human1.37280354
43* REST_21632747_ChIP-Seq_MESCs_Mouse1.36280093
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35677893
45ZNF274_21170338_ChIP-Seq_K562_Hela1.35007354
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34034156
47SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31283403
48JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.30586110
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30112372
50AR_21572438_ChIP-Seq_LNCaP_Human1.30058647
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29850556
52STAT1_17558387_ChIP-Seq_HELA_Human1.29788100
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29360910
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.27524842
55WDR5_24793694_ChIP-Seq_LNCAP_Human1.27065792
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.23203256
57ERA_21632823_ChIP-Seq_H3396_Human1.22742391
58RNF2_27304074_Chip-Seq_NSC_Mouse1.17999931
59* GATA3_21867929_ChIP-Seq_TH1_Mouse1.16213468
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15771009
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14834086
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14744872
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14426682
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12976708
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11869096
66NANOG_20526341_ChIP-Seq_ESCs_Human1.11464218
67* P53_21459846_ChIP-Seq_SAOS-2_Human1.11369309
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10281320
69SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09788346
70FOXH1_21741376_ChIP-Seq_EPCs_Human1.09373504
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08517846
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.08160850
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.08136061
74* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07859163
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.07583942
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07436294
77PHF8_20622854_ChIP-Seq_HELA_Human1.07241487
78MYC_27129775_Chip-Seq_CORNEA_Mouse1.06855277
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05934273
80LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05530868
81AR_21909140_ChIP-Seq_LNCAP_Human1.05200135
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04545778
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04466739
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.04000814
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.03355228
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03108740
87FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02206874
88TP53_22573176_ChIP-Seq_HFKS_Human1.01612694
89GATA3_21867929_ChIP-Seq_CD8_Mouse1.01563205
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01497372
91SOX11_22085726_ChIP-Seq_ESNs_Mouse1.01309663
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01176871
93E2F1_20622854_ChIP-Seq_HELA_Human1.00822163
94* SPI1_26923725_Chip-Seq_HPCs_Mouse1.00611932
95BP1_19119308_ChIP-ChIP_Hs578T_Human1.00308202
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99830609
97* RUNX2_22187159_ChIP-Seq_PCA_Human0.99170410
98AR_25329375_ChIP-Seq_VCAP_Human0.98608013
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98592597
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98293082
101ERG_20517297_ChIP-Seq_VCAP_Human0.98245823
102TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98085713
103PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97986624
104TCF4_23295773_ChIP-Seq_U87_Human0.97694587
105IRF1_19129219_ChIP-ChIP_H3396_Human0.97521333
106GF1_26923725_Chip-Seq_HPCs_Mouse0.97387658
107HTT_18923047_ChIP-ChIP_STHdh_Human0.97141164
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96314879
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96314879
110* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95564349
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95298556
112GATA3_26560356_Chip-Seq_TH1_Human0.94550007
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94318986
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94133972
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.93650270
116* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93465608
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92993240
118MYC_18940864_ChIP-ChIP_HL60_Human0.92788222
119PRDM14_20953172_ChIP-Seq_ESCs_Human0.92782273
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.91446011
121CTCF_27219007_Chip-Seq_Bcells_Human0.91345062
122MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91329921
123OCT4_19829295_ChIP-Seq_ESCs_Human0.90721959
124SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89073150
125FLI1_21867929_ChIP-Seq_CD8_Mouse0.89062643
126SOX2_21211035_ChIP-Seq_LN229_Human0.88798706
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88744703
128ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88586757
129VDR_23849224_ChIP-Seq_CD4+_Human0.87461155
130BCAT_22108803_ChIP-Seq_LS180_Human0.87311189
131EST1_17652178_ChIP-ChIP_JURKAT_Human0.86805382
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.86371289
133KDM2B_26808549_Chip-Seq_REH_Human0.86328462
134FOXP3_21729870_ChIP-Seq_TREG_Human0.85729980
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85690711
136* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85053326
137* TBL1_22424771_ChIP-Seq_293T_Human0.84255286
138THAP11_20581084_ChIP-Seq_MESCs_Mouse0.83807847
139CBP_20019798_ChIP-Seq_JUKART_Human0.83695202
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83695202
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83401023
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83245457
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.83185564
144E2F1_17053090_ChIP-ChIP_MCF-7_Human0.82877012
145DCP1A_22483619_ChIP-Seq_HELA_Human0.82616503
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82207501
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81958058
148ESRRB_18555785_Chip-Seq_ESCs_Mouse0.81899240
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81661300
150SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81564925
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81441442
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.80957061
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.80817758
154BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.80635121
155ER_23166858_ChIP-Seq_MCF-7_Human0.80411208
156STAT3_23295773_ChIP-Seq_U87_Human0.79986185
157* CTCF_20526341_ChIP-Seq_ESCs_Human0.79565487
158CBP_21632823_ChIP-Seq_H3396_Human0.79233559
159CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78248175
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77850038
161GABP_17652178_ChIP-ChIP_JURKAT_Human0.75884916
162PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75499722
163CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75321520
164E2F1_21310950_ChIP-Seq_MCF-7_Human0.73519319
165KLF4_19829295_ChIP-Seq_ESCs_Human0.73287265
166ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73063066
167JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.72781052
168CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72709999
169HOXB7_26014856_ChIP-Seq_BT474_Human0.72442464
170GABP_19822575_ChIP-Seq_HepG2_Human0.71276141
171EWS_26573619_Chip-Seq_HEK293_Human0.68583090
172MYC_19079543_ChIP-ChIP_MESCs_Mouse0.68290446
173P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.66989726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.56983932
2MP0001929_abnormal_gametogenesis5.40828109
3MP0008877_abnormal_DNA_methylation4.37877734
4MP0002210_abnormal_sex_determination3.58843350
5MP0008789_abnormal_olfactory_epithelium3.15932713
6MP0002161_abnormal_fertility/fecundity3.13907897
7MP0006292_abnormal_olfactory_placode3.11123288
8MP0003693_abnormal_embryo_hatching3.07217579
9MP0001145_abnormal_male_reproductive3.06543376
10MP0002009_preneoplasia3.00978895
11MP0005394_taste/olfaction_phenotype2.75189726
12MP0005499_abnormal_olfactory_system2.75189726
13MP0000653_abnormal_sex_gland2.70135958
14MP0005395_other_phenotype2.58949454
15MP0008057_abnormal_DNA_replication2.57790811
16MP0002160_abnormal_reproductive_system2.57215031
17MP0001986_abnormal_taste_sensitivity2.22480799
18MP0005670_abnormal_white_adipose2.10352568
19MP0002653_abnormal_ependyma_morphology2.08327494
20MP0005410_abnormal_fertilization13.9012232
21MP0010030_abnormal_orbit_morphology1.84350954
22MP0000678_abnormal_parathyroid_gland1.75367640
23MP0005389_reproductive_system_phenotype1.74472914
24MP0005257_abnormal_intraocular_pressure1.57169129
25MP0010307_abnormal_tumor_latency1.53460604
26MP0005360_urolithiasis1.48180590
27MP0010094_abnormal_chromosome_stability1.45040133
28MP0003646_muscle_fatigue1.42271584
29MP0003115_abnormal_respiratory_system1.38072761
30MP0009379_abnormal_foot_pigmentation1.36631809
31MP0008932_abnormal_embryonic_tissue1.32004163
32MP0010368_abnormal_lymphatic_system1.30238698
33MP0009046_muscle_twitch1.28749629
34MP0002090_abnormal_vision1.28233875
35MP0004957_abnormal_blastocyst_morpholog1.25996839
36MP0003283_abnormal_digestive_organ1.23426637
37MP0008004_abnormal_stomach_pH1.21733260
38MP0002282_abnormal_trachea_morphology1.16240574
39MP0010234_abnormal_vibrissa_follicle1.15423226
40MP0001984_abnormal_olfaction1.12908522
41MP0005623_abnormal_meninges_morphology1.11580927
42MP0008995_early_reproductive_senescence1.06361447
43MP0003950_abnormal_plasma_membrane1.05659134
44MP0000358_abnormal_cell_content/1.05488656
45MP0000631_abnormal_neuroendocrine_gland1.00508328
46MP0003567_abnormal_fetal_cardiomyocyte0.98218404
47MP0003315_abnormal_perineum_morphology0.97138322
48MP0006035_abnormal_mitochondrial_morpho0.97048986
49MP0001919_abnormal_reproductive_system0.96931051
50MP0005647_abnormal_sex_gland0.96580913
51MP0001529_abnormal_vocalization0.96494158
52MP0008007_abnormal_cellular_replicative0.94932325
53MP0000537_abnormal_urethra_morphology0.93760647
54MP0008961_abnormal_basal_metabolism0.93536374
55MP0003119_abnormal_digestive_system0.91998874
56MP0000350_abnormal_cell_proliferation0.91729151
57MP0000566_synostosis0.90465414
58MP0009780_abnormal_chondrocyte_physiolo0.87373494
59MP0001293_anophthalmia0.86531696
60MP0002233_abnormal_nose_morphology0.85936446
61MP0005171_absent_coat_pigmentation0.83993239
62MP0005377_hearing/vestibular/ear_phenot0.83242278
63MP0003878_abnormal_ear_physiology0.83242278
64MP0003121_genomic_imprinting0.82319170
65MP0004133_heterotaxia0.80690754
66MP0002084_abnormal_developmental_patter0.78692920
67MP0004233_abnormal_muscle_weight0.76128589
68MP0003699_abnormal_female_reproductive0.75580416
69MP0006276_abnormal_autonomic_nervous0.74890416
70MP0002751_abnormal_autonomic_nervous0.74189307
71MP0004811_abnormal_neuron_physiology0.71488088
72MP0005646_abnormal_pituitary_gland0.69786754
73MP0000427_abnormal_hair_cycle0.69383057
74MP0001765_abnormal_ion_homeostasis0.69262561
75MP0002572_abnormal_emotion/affect_behav0.68361609
76MP0004142_abnormal_muscle_tone0.67782007
77MP0003935_abnormal_craniofacial_develop0.67579272
78MP0002063_abnormal_learning/memory/cond0.67240801
79MP0000049_abnormal_middle_ear0.67063005
80MP0009840_abnormal_foam_cell0.66757934
81MP0002085_abnormal_embryonic_tissue0.66627134
82MP0003718_maternal_effect0.65584122
83MP0003861_abnormal_nervous_system0.63870971
84MP0002139_abnormal_hepatobiliary_system0.63382680
85MP0003786_premature_aging0.62951256
86MP0001119_abnormal_female_reproductive0.62244099
87MP0000313_abnormal_cell_death0.61533275
88MP0000762_abnormal_tongue_morphology0.61365385
89MP0004742_abnormal_vestibular_system0.61034726
90MP0002127_abnormal_cardiovascular_syste0.61024791
91MP0008260_abnormal_autophagy0.60761168
92MP0000015_abnormal_ear_pigmentation0.58208991
93MP0002152_abnormal_brain_morphology0.58171966
94MP0003941_abnormal_skin_development0.57294071
95MP0002234_abnormal_pharynx_morphology0.57263573
96MP0001502_abnormal_circadian_rhythm0.57121792
97MP0001666_abnormal_nutrient_absorption0.56729658
98MP0001664_abnormal_digestion0.56676166
99MP0003136_yellow_coat_color0.56555368
100MP0003984_embryonic_growth_retardation0.56287522
101MP0004270_analgesia0.55772167
102MP0002557_abnormal_social/conspecific_i0.54970030
103MP0002932_abnormal_joint_morphology0.54396597
104MP0001963_abnormal_hearing_physiology0.53811769
105MP0003252_abnormal_bile_duct0.52848722
106MP0002088_abnormal_embryonic_growth/wei0.52673048
107MP0002089_abnormal_postnatal_growth/wei0.52357390
108MP0008058_abnormal_DNA_repair0.51976546
109MP0003077_abnormal_cell_cycle0.49900698
110MP0010329_abnormal_lipoprotein_level0.49653746
111MP0002080_prenatal_lethality0.49287755
112MP0004197_abnormal_fetal_growth/weight/0.49043783
113MP0003635_abnormal_synaptic_transmissio0.48828812
114MP0002102_abnormal_ear_morphology0.48321404
115MP0003936_abnormal_reproductive_system0.46544081
116MP0003111_abnormal_nucleus_morphology0.46089073
117MP0005551_abnormal_eye_electrophysiolog0.45210277
118MP0003879_abnormal_hair_cell0.45101468
119MP0000428_abnormal_craniofacial_morphol0.45073222
120MP0000534_abnormal_ureter_morphology0.44238653
121MP0003937_abnormal_limbs/digits/tail_de0.43636521
122MP0005174_abnormal_tail_pigmentation0.43430045
123MP0001661_extended_life_span0.42788823
124MP0005253_abnormal_eye_physiology0.42705439
125MP0008770_decreased_survivor_rate0.42632080
126MP0001188_hyperpigmentation0.41227489
127MP0004885_abnormal_endolymph0.41167707
128MP0005423_abnormal_somatic_nervous0.40752936
129MP0000569_abnormal_digit_pigmentation0.40567154
130MP0010678_abnormal_skin_adnexa0.40380092
131MP0001730_embryonic_growth_arrest0.40357616
132MP0001324_abnormal_eye_pigmentation0.40322627
133MP0006036_abnormal_mitochondrial_physio0.38890762
134MP0005187_abnormal_penis_morphology0.38736613
135MP0003183_abnormal_peptide_metabolism0.38686081
136MP0001697_abnormal_embryo_size0.38262900
137MP0002269_muscular_atrophy0.38260246
138MP0005085_abnormal_gallbladder_physiolo0.38196713
139MP0005409_darkened_coat_color0.37982083
140MP0002735_abnormal_chemical_nociception0.37851735
141MP0003329_amyloid_beta_deposits0.37100456
142MP0000751_myopathy0.37095616
143MP0002882_abnormal_neuron_morphology0.37032480
144MP0002272_abnormal_nervous_system0.36680735
145MP0002796_impaired_skin_barrier0.36618951
146MP0003890_abnormal_embryonic-extraembry0.36560744
147MP0002067_abnormal_sensory_capabilities0.36358006
148MP0003880_abnormal_central_pattern0.35162003
149MP0001672_abnormal_embryogenesis/_devel0.35005902
150MP0005380_embryogenesis_phenotype0.35005902
151MP0005636_abnormal_mineral_homeostasis0.34442414
152MP0000778_abnormal_nervous_system0.34103066
153MP0008569_lethality_at_weaning0.33797285
154MP0005195_abnormal_posterior_eye0.33219334
155MP0003948_abnormal_gas_homeostasis0.32436394
156MP0003942_abnormal_urinary_system0.30098001
157MP0002138_abnormal_hepatobiliary_system0.30068258
158MP0001440_abnormal_grooming_behavior0.30054569

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.86289897
2Absent/shortened dynein arms (HP:0200106)9.86289897
3Abnormal respiratory motile cilium physiology (HP:0012261)7.01469469
4Abnormal respiratory motile cilium morphology (HP:0005938)6.82237183
5Abnormal respiratory epithelium morphology (HP:0012253)6.82237183
6Conjugated hyperbilirubinemia (HP:0002908)6.76447407
7Rhinitis (HP:0012384)6.05350809
8Chronic bronchitis (HP:0004469)5.71167369
9Infertility (HP:0000789)5.66128033
10Peritonitis (HP:0002586)5.33330322
11Abnormal ciliary motility (HP:0012262)5.23470647
12Osteomalacia (HP:0002749)5.03628147
13Progressive cerebellar ataxia (HP:0002073)4.99200857
14Elevated erythrocyte sedimentation rate (HP:0003565)4.84636449
15Dyschromatopsia (HP:0007641)4.80157095
16Nasal polyposis (HP:0100582)4.62894971
17Insidious onset (HP:0003587)4.53554895
18Termporal pattern (HP:0011008)4.53554895
19Oligodactyly (hands) (HP:0001180)4.37350183
20Facial hemangioma (HP:0000329)4.18733928
21Abnormality of abdominal situs (HP:0011620)4.14975570
22Abdominal situs inversus (HP:0003363)4.14975570
23Nephrogenic diabetes insipidus (HP:0009806)4.10257610
24Lip pit (HP:0100267)4.04283140
25Abnormality of the nasal mucosa (HP:0000433)3.73645285
26Male infertility (HP:0003251)3.72597709
27Central scotoma (HP:0000603)3.66807984
28Spontaneous abortion (HP:0005268)3.66070193
29Anterior segment dysgenesis (HP:0007700)3.65798852
30Premature ovarian failure (HP:0008209)3.62837397
31Papillary thyroid carcinoma (HP:0002895)3.54342982
32Progressive external ophthalmoplegia (HP:0000590)3.54007795
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.44585862
34Pancreatic cysts (HP:0001737)3.37963359
35Renal tubular acidosis (HP:0001947)3.34385378
36Bronchiectasis (HP:0002110)3.31816626
37Bronchitis (HP:0012387)3.31381683
38Nephronophthisis (HP:0000090)3.28507658
39Aplasia/Hypoplasia of the fovea (HP:0008060)3.25132394
40Hypoplasia of the fovea (HP:0007750)3.25132394
41Hypophosphatemic rickets (HP:0004912)3.24596437
42Medial flaring of the eyebrow (HP:0010747)3.20644743
43Median cleft lip (HP:0000161)3.18923271
44Oligodactyly (HP:0012165)3.18473926
45Abnormal spermatogenesis (HP:0008669)3.12922189
46Abnormality of the fovea (HP:0000493)2.99562233
47Loss of speech (HP:0002371)2.85124563
48Lissencephaly (HP:0001339)2.81104708
49Short tibia (HP:0005736)2.76364284
50Capillary hemangiomas (HP:0005306)2.75562725
51Volvulus (HP:0002580)2.74104015
52Malnutrition (HP:0004395)2.68877612
53Truncal obesity (HP:0001956)2.68419989
54Abnormal lung lobation (HP:0002101)2.68031851
55Abnormality of the peritoneum (HP:0002585)2.62695145
56Recurrent otitis media (HP:0000403)2.62197887
57Absent septum pellucidum (HP:0001331)2.60422931
58True hermaphroditism (HP:0010459)2.59900283
59Progressive sensorineural hearing impairment (HP:0000408)2.56620437
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54222468
61Pancreatic fibrosis (HP:0100732)2.53559227
62Abnormality of the labia minora (HP:0012880)2.47675722
63Abnormal auditory evoked potentials (HP:0006958)2.47535956
64Gait imbalance (HP:0002141)2.46483722
65Congenital primary aphakia (HP:0007707)2.41236490
66Small intestinal stenosis (HP:0012848)2.40455256
67Duodenal stenosis (HP:0100867)2.40455256
68Neuroendocrine neoplasm (HP:0100634)2.40010671
69Abnormality of the lower motor neuron (HP:0002366)2.39542082
70Septo-optic dysplasia (HP:0100842)2.38101699
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.37765710
72Cystic liver disease (HP:0006706)2.37622705
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34891219
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.34891219
75Abnormality of the renal medulla (HP:0100957)2.33939167
76Abnormality of DNA repair (HP:0003254)2.32947360
77Hypergonadotropic hypogonadism (HP:0000815)2.32944094
78Nephroblastoma (Wilms tumor) (HP:0002667)2.32502523
79Gonadotropin excess (HP:0000837)2.32398204
80Proximal tubulopathy (HP:0000114)2.31215883
81Cholecystitis (HP:0001082)2.30505305
82Abnormal gallbladder physiology (HP:0012438)2.30505305
83Shoulder girdle muscle weakness (HP:0003547)2.28460046
84Impulsivity (HP:0100710)2.28443023
85Urethral obstruction (HP:0000796)2.27388567
86Abnormality of the septum pellucidum (HP:0007375)2.24251456
87Ectopic kidney (HP:0000086)2.23229881
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23097184
89Increased variability in muscle fiber diameter (HP:0003557)2.22978544
90Hip dysplasia (HP:0001385)2.18859519
91Wrist flexion contracture (HP:0001239)2.18303589
92Embryonal renal neoplasm (HP:0011794)2.17287750
93Postaxial foot polydactyly (HP:0001830)2.16565363
94Sensory axonal neuropathy (HP:0003390)2.16418933
95Increased nuchal translucency (HP:0010880)2.13969541
96Hypokinesia (HP:0002375)2.12916738
97Abnormality of chromosome segregation (HP:0002916)2.11818039
98Hand muscle atrophy (HP:0009130)2.09813317
99Recurrent sinusitis (HP:0011108)2.07868002
100Fatigue (HP:0012378)2.07149240
101Pelvic girdle muscle weakness (HP:0003749)2.06128156
102Chromsome breakage (HP:0040012)2.05781754
103Generalized aminoaciduria (HP:0002909)2.04929306
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.03059357
105Bundle branch block (HP:0011710)2.02982498
106Microglossia (HP:0000171)2.02392489
107Skin pits (HP:0100276)2.02094314
108Scotoma (HP:0000575)2.01651502
109Abnormality of chromosome stability (HP:0003220)2.01627497
110Aplasia/Hypoplasia of the macula (HP:0008059)2.01530595
111Aplasia/Hypoplasia of the uvula (HP:0010293)2.00973352
112Azoospermia (HP:0000027)2.00470756
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.2153338
114Abnormality of skeletal muscle fiber size (HP:0012084)1.97368077
115Increased connective tissue (HP:0009025)1.94712038
116Renal tubular dysfunction (HP:0000124)1.93461862
117Metaphyseal irregularity (HP:0003025)1.92680639
118Conjunctival telangiectasia (HP:0000524)1.92481622
119Aplasia/Hypoplasia of the lens (HP:0008063)1.92449729
120Abnormality of the preputium (HP:0100587)1.92406846
121Amyotrophic lateral sclerosis (HP:0007354)1.92091127
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.91713220
123Enlarged penis (HP:0000040)1.90399499
124Horizontal nystagmus (HP:0000666)1.89917354
125Abnormality of cochlea (HP:0000375)1.89723454
126Non-midline cleft lip (HP:0100335)1.89681676
127Absent radius (HP:0003974)1.87846044
128Renal dysplasia (HP:0000110)1.85017452
129Hyperpituitarism (HP:0010514)1.84871776
130Abnormality of the ileum (HP:0001549)1.84650674
131Abnormality of the duodenum (HP:0002246)1.84108424
132Impaired vibration sensation in the lower limbs (HP:0002166)1.82675381
133Abnormality of the hip-girdle musculature (HP:0001445)1.82022494
134Abnormality of the musculature of the pelvis (HP:0001469)1.82022494
135Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81867610
136Apathy (HP:0000741)1.81827991
137Tubular atrophy (HP:0000092)1.81754524
138Supernumerary spleens (HP:0009799)1.81257006
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.80067039
140Aplasia of the musculature (HP:0100854)1.78372917
141Abnormality of the phalanges of the hallux (HP:0010057)1.78332803
142Poor coordination (HP:0002370)1.77815303
143Diminished motivation (HP:0000745)1.77222731
144Vaginal atresia (HP:0000148)1.75647433
145Progressive hearing impairment (HP:0001730)1.74815834
146Tubulointerstitial abnormality (HP:0001969)1.74667225
147Abnormality of the corticospinal tract (HP:0002492)1.74574645
148Aplasia involving forearm bones (HP:0009822)1.74285516
149Absent forearm bone (HP:0003953)1.74285516
150Polycythemia (HP:0001901)1.74203424
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73749092
152Posterior subcapsular cataract (HP:0007787)1.73033008
153Fair hair (HP:0002286)1.72655034
154Abnormality of the renal collecting system (HP:0004742)1.72354799
155Lower limb hyperreflexia (HP:0002395)1.71941334
156Recurrent bronchitis (HP:0002837)1.71524559
157Stillbirth (HP:0003826)1.70979382
158Congenital hepatic fibrosis (HP:0002612)1.70244034
159Tubulointerstitial fibrosis (HP:0005576)1.70181381
160Abnormality of vision evoked potentials (HP:0000649)1.69826218
161Genital tract atresia (HP:0001827)1.68559004
162Rimmed vacuoles (HP:0003805)1.66430689
163Sloping forehead (HP:0000340)1.65960398
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64697582
165Pheochromocytoma (HP:0002666)1.63306898
166Limb dystonia (HP:0002451)1.60844829
167Large eyes (HP:0001090)1.59864788
168Abnormality of midbrain morphology (HP:0002418)1.59862390
169Molar tooth sign on MRI (HP:0002419)1.59862390
170Difficulty running (HP:0009046)1.58770566
171Tubulointerstitial nephritis (HP:0001970)1.57987694
172Specific learning disability (HP:0001328)1.55320953
173Nephrocalcinosis (HP:0000121)1.53730794
174External ophthalmoplegia (HP:0000544)1.53703637
175Oligohydramnios (HP:0001562)1.52206562
176Sclerocornea (HP:0000647)1.51996466
177Meckel diverticulum (HP:0002245)1.51155290
178Stage 5 chronic kidney disease (HP:0003774)1.51129329
179Nephropathy (HP:0000112)1.50669364
180Hypertensive crisis (HP:0100735)1.50403448
181Heterotopia (HP:0002282)1.50179282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.11218879
2PDK47.11218879
3TESK15.73929056
4CDK194.82843905
5PDK24.50398158
6MAP3K134.45631990
7ARAF4.35276830
8PRKD34.17247305
9ICK3.79701414
10NUAK13.63735806
11MET2.86704340
12NEK62.75781139
13BRAF2.72694395
14MAP3K112.71197622
15DYRK32.39726608
16NEK22.36731620
17STK242.17031686
18KSR22.11789723
19PTK2B1.95813296
20PNCK1.90093339
21TAOK31.84737639
22WNK41.84129225
23STK391.83843196
24MOS1.79585117
25STK381.67691603
26TLK11.58333193
27RAF11.53339961
28PRKCI1.52904611
29CDK91.39053570
30CDK71.32482327
31TYRO31.27566729
32KSR11.25557808
33OXSR11.22251350
34NME21.20728652
35STK38L1.16757064
36DYRK1B1.15960085
37CHEK21.15506997
38TRIM281.10886921
39STK161.10712927
40MARK31.07948170
41PTK21.07365204
42MELK1.06475481
43EPHB21.04649494
44EIF2AK31.02487684
45RPS6KA41.01666855
46TESK20.99300940
47NEK90.98524483
48ACVR1B0.92885370
49MAP3K80.88594464
50ZAK0.85995625
51SRPK10.83375670
52NTRK30.79225337
53MARK10.76309763
54BMPR1B0.73153842
55WNK30.73124517
56PIM10.73004673
57VRK10.72586223
58CAMKK10.69556688
59NTRK20.66876666
60STK110.66283482
61MAPK150.64999785
62BRSK10.64970715
63MTOR0.64229168
64BRSK20.63907038
65AURKB0.62967387
66MAP3K40.62570095
67PDK10.60267377
68TTK0.59566010
69BUB10.59345311
70CCNB10.58400195
71PBK0.57364810
72WNK10.57216352
73DYRK20.57192983
74CDK40.56640776
75STK30.54365248
76CDK80.53683921
77PRKG10.53573167
78PRKAA10.53014204
79WEE10.52703235
80PLK20.50919239
81MAPK110.50758766
82EEF2K0.48192207
83MAP2K20.48140464
84PLK30.47246965
85CSF1R0.47096332
86MAP3K50.46506040
87PLK10.43977161
88PRKD20.43949446
89PASK0.42915973
90PRKCZ0.42365653
91CDC70.41658385
92CHEK10.41555654
93AURKA0.40479141
94MKNK20.39120135
95CSNK1G10.38277129
96EGFR0.37701174
97RPS6KB10.37268152
98ATR0.36101056
99CDK11A0.35710778
100PRKCG0.32866392
101PRKACB0.32848781
102RET0.31862169
103PLK40.31740139
104AKT20.31043818
105SGK4940.30413744
106SGK2230.30413744
107CSNK2A20.29225852
108MAPK10.27648323
109PAK60.27163763
110TNK20.27017700
111PAK10.26412778
112SGK20.25713818
113MAPK130.25071560
114CDK140.24979634
115CDK30.24783898
116PRKCB0.24414139
117PINK10.24223796
118CDK60.24116066
119EPHA40.24041535
120ATM0.23835677
121CAMK2A0.23786172
122BMX0.23672987
123LIMK10.22904246
124LATS20.22227163
125BRD40.22222328
126CSNK1D0.22071289
127LMTK20.21765443
128PKN10.20717803
129MAPK100.20284850
130CDK10.19466844
131PRKAA20.18984415
132MUSK0.18017517
133MINK10.17080536
134PDPK10.15709846
135MAP3K90.15706174
136CDK120.15664340
137IRAK20.15534319
138CAMK2B0.13771759
139IRAK10.13700566
140CDK20.13196984
141PAK20.13103540
142NME10.12594639
143GSK3A0.12563026
144PRKACG0.12385290
145RIPK40.12309875
146CSNK2A10.12219202
147CSNK1E0.11674068
148RPS6KA50.11244454
149HIPK20.11111523
150CDK180.10813782
151CDK150.10772298
152GSK3B0.10059890
153CAMK1G0.09890155

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.49799851
2Mismatch repair_Homo sapiens_hsa034304.03028701
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.01515129
4Homologous recombination_Homo sapiens_hsa034403.66054709
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.54894031
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.44866504
7DNA replication_Homo sapiens_hsa030303.42438092
8Dorso-ventral axis formation_Homo sapiens_hsa043203.38148527
9Linoleic acid metabolism_Homo sapiens_hsa005913.34047850
10Base excision repair_Homo sapiens_hsa034103.26338214
11Fatty acid biosynthesis_Homo sapiens_hsa000613.05291137
12Pyruvate metabolism_Homo sapiens_hsa006202.83450176
13Nucleotide excision repair_Homo sapiens_hsa034202.83374757
14Basal transcription factors_Homo sapiens_hsa030222.63142750
15Glucagon signaling pathway_Homo sapiens_hsa049222.61617271
16RNA degradation_Homo sapiens_hsa030182.41615761
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17707311
18Ovarian steroidogenesis_Homo sapiens_hsa049132.02231417
19Fanconi anemia pathway_Homo sapiens_hsa034601.92708175
20Oocyte meiosis_Homo sapiens_hsa041141.90889394
21Propanoate metabolism_Homo sapiens_hsa006401.87554308
22Amphetamine addiction_Homo sapiens_hsa050311.86670185
23Sulfur relay system_Homo sapiens_hsa041221.85076036
24Fat digestion and absorption_Homo sapiens_hsa049751.77773919
25Folate biosynthesis_Homo sapiens_hsa007901.77478710
26p53 signaling pathway_Homo sapiens_hsa041151.73497324
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.72647524
28Glycerolipid metabolism_Homo sapiens_hsa005611.72488065
29Regulation of autophagy_Homo sapiens_hsa041401.67361585
30Selenocompound metabolism_Homo sapiens_hsa004501.61804810
31Caffeine metabolism_Homo sapiens_hsa002321.57107237
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55779710
33Olfactory transduction_Homo sapiens_hsa047401.53317383
34Non-homologous end-joining_Homo sapiens_hsa034501.48461560
35Ether lipid metabolism_Homo sapiens_hsa005651.46473025
36RNA polymerase_Homo sapiens_hsa030201.43829153
37RNA transport_Homo sapiens_hsa030131.43146872
38Fatty acid degradation_Homo sapiens_hsa000711.42817797
39Pentose phosphate pathway_Homo sapiens_hsa000301.39524084
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39265435
41PPAR signaling pathway_Homo sapiens_hsa033201.31613259
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27415440
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24894809
44Fatty acid metabolism_Homo sapiens_hsa012121.16766328
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.16491989
46Antigen processing and presentation_Homo sapiens_hsa046121.16329608
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09760597
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08400601
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04941886
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04224702
51Renin secretion_Homo sapiens_hsa049241.04177736
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00564047
53Cardiac muscle contraction_Homo sapiens_hsa042600.98715306
54Arachidonic acid metabolism_Homo sapiens_hsa005900.97674541
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96498329
56mRNA surveillance pathway_Homo sapiens_hsa030150.96304132
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94627668
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93802832
59Gap junction_Homo sapiens_hsa045400.92687227
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91855140
61mTOR signaling pathway_Homo sapiens_hsa041500.90115666
62Inositol phosphate metabolism_Homo sapiens_hsa005620.89607979
63Carbon metabolism_Homo sapiens_hsa012000.87837926
64Cocaine addiction_Homo sapiens_hsa050300.87766226
65Sulfur metabolism_Homo sapiens_hsa009200.86376780
66Huntingtons disease_Homo sapiens_hsa050160.86263552
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82430054
68Purine metabolism_Homo sapiens_hsa002300.81804437
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81439651
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.77604693
71Long-term potentiation_Homo sapiens_hsa047200.76810457
72ABC transporters_Homo sapiens_hsa020100.76595934
73Insulin secretion_Homo sapiens_hsa049110.76317964
74Estrogen signaling pathway_Homo sapiens_hsa049150.75702996
75Hedgehog signaling pathway_Homo sapiens_hsa043400.73251590
76Chemical carcinogenesis_Homo sapiens_hsa052040.72721474
77Mineral absorption_Homo sapiens_hsa049780.72207116
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72072687
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71915592
80Fatty acid elongation_Homo sapiens_hsa000620.71868061
81Peroxisome_Homo sapiens_hsa041460.71321410
82Fructose and mannose metabolism_Homo sapiens_hsa000510.69873155
83TGF-beta signaling pathway_Homo sapiens_hsa043500.68888772
84Endocytosis_Homo sapiens_hsa041440.68420990
85Taste transduction_Homo sapiens_hsa047420.68008271
86Biosynthesis of amino acids_Homo sapiens_hsa012300.66595212
87Phototransduction_Homo sapiens_hsa047440.66536469
88Tyrosine metabolism_Homo sapiens_hsa003500.62170718
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61280506
90Thyroid cancer_Homo sapiens_hsa052160.60346068
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59181226
92Ribosome_Homo sapiens_hsa030100.59076896
93Thyroid hormone synthesis_Homo sapiens_hsa049180.58476547
94Systemic lupus erythematosus_Homo sapiens_hsa053220.57998855
95Viral carcinogenesis_Homo sapiens_hsa052030.56675219
96Legionellosis_Homo sapiens_hsa051340.56191100
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56133604
98Cell cycle_Homo sapiens_hsa041100.55394677
99Retinol metabolism_Homo sapiens_hsa008300.52593802
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50938752
101Spliceosome_Homo sapiens_hsa030400.48565624
102Circadian entrainment_Homo sapiens_hsa047130.46190532
103Small cell lung cancer_Homo sapiens_hsa052220.45808742
104AMPK signaling pathway_Homo sapiens_hsa041520.44513805
105HTLV-I infection_Homo sapiens_hsa051660.44379255
106Alcoholism_Homo sapiens_hsa050340.44367363
107Steroid biosynthesis_Homo sapiens_hsa001000.43175495
108Nicotine addiction_Homo sapiens_hsa050330.41853256
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41506133
110Protein digestion and absorption_Homo sapiens_hsa049740.41352757
111FoxO signaling pathway_Homo sapiens_hsa040680.37195170
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.37084228
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37057024
114Bile secretion_Homo sapiens_hsa049760.35936813
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.35691305
116Glutathione metabolism_Homo sapiens_hsa004800.35575815
117VEGF signaling pathway_Homo sapiens_hsa043700.35123546
118Pyrimidine metabolism_Homo sapiens_hsa002400.32200827
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32052853
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32018431
121Glutamatergic synapse_Homo sapiens_hsa047240.31915037
122Dopaminergic synapse_Homo sapiens_hsa047280.31376357
123Wnt signaling pathway_Homo sapiens_hsa043100.30061767
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27581174
125Basal cell carcinoma_Homo sapiens_hsa052170.26975829
126ErbB signaling pathway_Homo sapiens_hsa040120.26626870
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.26081067
128Lysine degradation_Homo sapiens_hsa003100.25665890
129Herpes simplex infection_Homo sapiens_hsa051680.25493123
130Synaptic vesicle cycle_Homo sapiens_hsa047210.25223105
131Starch and sucrose metabolism_Homo sapiens_hsa005000.25093825
132Metabolic pathways_Homo sapiens_hsa011000.24945496
133Adherens junction_Homo sapiens_hsa045200.23684172
134Circadian rhythm_Homo sapiens_hsa047100.23386595
135Calcium signaling pathway_Homo sapiens_hsa040200.23004642
136Vitamin digestion and absorption_Homo sapiens_hsa049770.22797064
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.22515740
138Pancreatic secretion_Homo sapiens_hsa049720.22475251
139Insulin resistance_Homo sapiens_hsa049310.21065358
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.20403937
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20392936
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19568500
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19471081
144Arginine and proline metabolism_Homo sapiens_hsa003300.19422573
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18151626
146MicroRNAs in cancer_Homo sapiens_hsa052060.16334045
147Notch signaling pathway_Homo sapiens_hsa043300.16047025
148Serotonergic synapse_Homo sapiens_hsa047260.15199327
149Morphine addiction_Homo sapiens_hsa050320.14292892
150Long-term depression_Homo sapiens_hsa047300.14249845
151Epstein-Barr virus infection_Homo sapiens_hsa051690.13507733
152Prostate cancer_Homo sapiens_hsa052150.11101047
153Proteasome_Homo sapiens_hsa030500.10850006
154Phenylalanine metabolism_Homo sapiens_hsa003600.10145154
155MAPK signaling pathway_Homo sapiens_hsa040100.09429436
156Choline metabolism in cancer_Homo sapiens_hsa052310.06112362
157Endometrial cancer_Homo sapiens_hsa052130.04980569
158Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04076346
159GABAergic synapse_Homo sapiens_hsa047270.03432116
160Maturity onset diabetes of the young_Homo sapiens_hsa049500.03389308
161Parkinsons disease_Homo sapiens_hsa050120.03216950
162Ras signaling pathway_Homo sapiens_hsa040140.02614381

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