DMRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.27204502
2DNA methylation involved in gamete generation (GO:0043046)7.40668661
3synaptonemal complex assembly (GO:0007130)7.03081729
4synapsis (GO:0007129)6.46691393
5synaptonemal complex organization (GO:0070193)6.37990715
6* regulation of meiosis I (GO:0060631)6.13415931
7male meiosis (GO:0007140)5.95305056
8gonadal mesoderm development (GO:0007506)5.70960425
9nuclear pore organization (GO:0006999)5.67221931
10nuclear pore complex assembly (GO:0051292)5.66458626
11behavioral response to nicotine (GO:0035095)5.40669644
12heterochromatin organization (GO:0070828)5.37552049
13* positive regulation of meiosis (GO:0045836)5.29347244
14histone H4-K12 acetylation (GO:0043983)5.29332534
15regulation of posttranscriptional gene silencing (GO:0060147)5.08235623
16regulation of gene silencing by miRNA (GO:0060964)5.08235623
17regulation of gene silencing by RNA (GO:0060966)5.08235623
18meiotic nuclear division (GO:0007126)5.03515237
19chromosome organization involved in meiosis (GO:0070192)4.99237000
20DNA replication checkpoint (GO:0000076)4.97978444
21* positive regulation of meiotic cell cycle (GO:0051446)4.90548951
22meiotic chromosome segregation (GO:0045132)4.81475666
23gene silencing by RNA (GO:0031047)4.76785423
24oogenesis (GO:0048477)4.73768689
25DNA methylation (GO:0006306)4.61135182
26DNA alkylation (GO:0006305)4.61135182
27pre-miRNA processing (GO:0031054)4.44390609
28mitotic chromosome condensation (GO:0007076)4.39536268
29chromatin remodeling at centromere (GO:0031055)4.37917676
30DNA replication-dependent nucleosome organization (GO:0034723)4.27406885
31DNA replication-dependent nucleosome assembly (GO:0006335)4.27406885
32replication fork processing (GO:0031297)4.23423021
33histone H4-K8 acetylation (GO:0043982)4.22706166
34histone H4-K5 acetylation (GO:0043981)4.22706166
35pore complex assembly (GO:0046931)4.13498592
36* sex determination (GO:0007530)4.11251545
37gene silencing (GO:0016458)4.04387709
38attachment of spindle microtubules to kinetochore (GO:0008608)3.93669191
39chromatin assembly (GO:0031497)3.92561684
40reciprocal DNA recombination (GO:0035825)3.91972731
41reciprocal meiotic recombination (GO:0007131)3.91972731
42male meiosis I (GO:0007141)3.89704379
43meiotic cell cycle process (GO:1903046)3.84977226
44CENP-A containing nucleosome assembly (GO:0034080)3.84506908
45ubiquinone biosynthetic process (GO:0006744)3.83685263
46sympathetic nervous system development (GO:0048485)3.81186021
47regulation of histone H3-K9 methylation (GO:0051570)3.80059232
48female gamete generation (GO:0007292)3.79387001
49DNA methylation or demethylation (GO:0044728)3.73717386
50mitotic G1 DNA damage checkpoint (GO:0031571)3.70197237
51mitotic nuclear envelope disassembly (GO:0007077)3.67557020
52regulation of RNA export from nucleus (GO:0046831)3.67192856
53negative regulation of DNA-dependent DNA replication (GO:2000104)3.60233622
54ubiquinone metabolic process (GO:0006743)3.59861803
55parturition (GO:0007567)3.55473327
56protein localization to cilium (GO:0061512)3.53760557
57protein polyglutamylation (GO:0018095)3.53757262
58centriole replication (GO:0007099)3.53298707
59regulation of DNA endoreduplication (GO:0032875)3.50518752
60histone H3-K9 methylation (GO:0051567)3.50251367
61DNA unwinding involved in DNA replication (GO:0006268)3.50075679
62membrane disassembly (GO:0030397)3.48029297
63nuclear envelope disassembly (GO:0051081)3.48029297
64somite rostral/caudal axis specification (GO:0032525)3.46897222
65sister chromatid cohesion (GO:0007062)3.45484418
66kinetochore organization (GO:0051383)3.45347761
67establishment of apical/basal cell polarity (GO:0035089)3.45175396
68histone exchange (GO:0043486)3.44727531
69seminiferous tubule development (GO:0072520)3.43103958
70inner cell mass cell proliferation (GO:0001833)3.42614501
71microtubule severing (GO:0051013)3.42245251
72paraxial mesoderm development (GO:0048339)3.42158478
73ribosomal small subunit assembly (GO:0000028)3.41055851
74protein-cofactor linkage (GO:0018065)3.40909826
75negative regulation of chromosome segregation (GO:0051985)3.37102020
76G1 DNA damage checkpoint (GO:0044783)3.35972326
77regulation of protein polyubiquitination (GO:1902914)3.34114457
78kinetochore assembly (GO:0051382)3.33666319
79neural tube formation (GO:0001841)3.29308438
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.27412817
81negative regulation of DNA repair (GO:0045738)3.26529274
82histone H4-K16 acetylation (GO:0043984)3.26147285
83mitotic spindle assembly checkpoint (GO:0007094)3.25687257
84meiosis I (GO:0007127)3.25550484
85peptidyl-lysine dimethylation (GO:0018027)3.25204994
86histone H2A acetylation (GO:0043968)3.25027870
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23435732
88mitotic G1/S transition checkpoint (GO:0044819)3.23295183
89spindle assembly checkpoint (GO:0071173)3.22565091
90regulation of nucleobase-containing compound transport (GO:0032239)3.19746069
91regulation of double-strand break repair (GO:2000779)3.18449536
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.17696579
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17696579
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.17340672
95negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17340672
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17340672
97negative regulation of sister chromatid segregation (GO:0033046)3.17340672
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16697346
99embryonic foregut morphogenesis (GO:0048617)3.16416203
100regulation of DNA damage checkpoint (GO:2000001)3.15613579
101chromatin silencing (GO:0006342)3.15580426
102regulation of helicase activity (GO:0051095)3.15015157
103protein localization to kinetochore (GO:0034501)3.14055853
104behavioral response to ethanol (GO:0048149)3.12491202
105double-strand break repair via homologous recombination (GO:0000724)3.12458346
106RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12427531
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12427531
108DNA modification (GO:0006304)3.11674993
109mitotic spindle checkpoint (GO:0071174)3.11664116
110protein K6-linked ubiquitination (GO:0085020)3.11402463
111DNA replication initiation (GO:0006270)3.11080404
112resolution of meiotic recombination intermediates (GO:0000712)3.10115131
113snRNA processing (GO:0016180)3.09458952
114* oocyte development (GO:0048599)3.08611554
115mitotic sister chromatid cohesion (GO:0007064)3.08469773
116spliceosomal tri-snRNP complex assembly (GO:0000244)3.08112945
117mRNA transport (GO:0051028)3.08019701
118recombinational repair (GO:0000725)3.07904827
119negative regulation of histone methylation (GO:0031061)3.06874415
120negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.06312390
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06273430
122snRNA metabolic process (GO:0016073)3.05841570
123regulation of nuclear cell cycle DNA replication (GO:0033262)3.04335378
124* sex differentiation (GO:0007548)3.04263668
125regulation of mitotic sister chromatid separation (GO:0010965)3.03016203
126regulation of mitotic sister chromatid segregation (GO:0033047)3.03016203
127regulation of sister chromatid segregation (GO:0033045)3.03016203
128quinone biosynthetic process (GO:1901663)3.02843495
129regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01884766
130DNA duplex unwinding (GO:0032508)3.01803690
131DNA catabolic process, exonucleolytic (GO:0000738)3.00831914
132regulation of chromosome segregation (GO:0051983)3.00717971
133DNA geometric change (GO:0032392)3.00368824
134regulation of gene silencing (GO:0060968)2.99849195
135histone H3-K9 modification (GO:0061647)2.99133982
136meiotic cell cycle (GO:0051321)2.97806946
137negative regulation of histone modification (GO:0031057)2.97239035
138nucleotide transmembrane transport (GO:1901679)2.97059816
139mitotic recombination (GO:0006312)2.96525932
140* regulation of meiosis (GO:0040020)2.94843309
141DNA strand renaturation (GO:0000733)2.94656760
142telomere maintenance via semi-conservative replication (GO:0032201)2.93005614
143DNA-dependent DNA replication (GO:0006261)2.87341477
144DNA double-strand break processing (GO:0000729)2.85588679
145glycerophospholipid catabolic process (GO:0046475)2.83623386
146positive regulation of cAMP-mediated signaling (GO:0043950)2.82167660
147intra-S DNA damage checkpoint (GO:0031573)2.69768323
148* regulation of meiotic cell cycle (GO:0051445)2.69132974
149DNA replication-independent nucleosome organization (GO:0034724)2.68548164
150DNA replication-independent nucleosome assembly (GO:0006336)2.68548164
151somatic diversification of immunoglobulins (GO:0016445)2.68307694
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.67038188
153DNA damage response, detection of DNA damage (GO:0042769)2.66143784
154DNA recombination (GO:0006310)2.62084138
155regulation of double-strand break repair via homologous recombination (GO:0010569)2.61228624
156ncRNA 3-end processing (GO:0043628)2.60649942
157double-strand break repair (GO:0006302)2.59122981
158synaptic transmission, cholinergic (GO:0007271)2.57153345
159telomere maintenance via recombination (GO:0000722)2.56317981
160mitochondrial DNA replication (GO:0006264)2.55760968
161single strand break repair (GO:0000012)2.55401723
162phosphorelay signal transduction system (GO:0000160)2.55252478
163axoneme assembly (GO:0035082)2.54519184
164sperm motility (GO:0030317)2.54420485
165centrosome organization (GO:0051297)2.53078209
166phosphatidylethanolamine biosynthetic process (GO:0006646)2.51924963
167negative regulation of DNA recombination (GO:0045910)2.51740588
168negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.50155949
169left/right axis specification (GO:0070986)2.49900079
170regulation of centrosome cycle (GO:0046605)2.48986368
171microtubule depolymerization (GO:0007019)2.48863082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.52462243
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53530083
3IGF1R_20145208_ChIP-Seq_DFB_Human4.14909167
4VDR_22108803_ChIP-Seq_LS180_Human3.83690650
5ZNF274_21170338_ChIP-Seq_K562_Hela3.56186823
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.56069372
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.51295971
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42303005
9* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31306548
10* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31306548
11* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31306548
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.05917511
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.93394449
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89236093
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.74925268
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74038454
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68811192
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.60411385
19EZH2_22144423_ChIP-Seq_EOC_Human2.59118924
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52116315
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.39261440
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.35544232
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31339195
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29683815
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.23684469
26IRF1_19129219_ChIP-ChIP_H3396_Human2.23198811
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.22133623
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.22004971
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20465427
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16362627
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14237163
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09016498
33AR_21909140_ChIP-Seq_LNCAP_Human2.05535638
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01782751
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97922159
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.97827785
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96681869
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93483036
39EWS_26573619_Chip-Seq_HEK293_Human1.93265573
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85932270
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85861023
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81853506
43TAF15_26573619_Chip-Seq_HEK293_Human1.81797160
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.80167739
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80112809
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78951753
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73079016
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68956675
49XRN2_22483619_ChIP-Seq_HELA_Human1.68935287
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68789193
51GBX2_23144817_ChIP-Seq_PC3_Human1.67350607
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65953366
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64792533
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63244180
55TP53_22573176_ChIP-Seq_HFKS_Human1.62735517
56KDM5A_27292631_Chip-Seq_BREAST_Human1.59947070
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59609602
58MYC_18940864_ChIP-ChIP_HL60_Human1.58827916
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58061730
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57992423
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57786717
62NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56423975
63* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56209310
64ZNF263_19887448_ChIP-Seq_K562_Human1.53363209
65FUS_26573619_Chip-Seq_HEK293_Human1.52860682
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50677509
67P300_19829295_ChIP-Seq_ESCs_Human1.48964230
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48396688
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46579293
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46498493
71MYC_22102868_ChIP-Seq_BL_Human1.45817504
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45248941
73* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43282978
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41905424
75CIITA_25753668_ChIP-Seq_RAJI_Human1.40090236
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39623592
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.35931405
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34281346
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34267483
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34242778
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.33360760
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32955743
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.32955743
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.32179147
85* RNF2_27304074_Chip-Seq_NSC_Mouse1.31783506
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30681268
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29916734
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29898716
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29720657
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.28230082
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.27223316
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27105839
93BCAT_22108803_ChIP-Seq_LS180_Human1.26820625
94DCP1A_22483619_ChIP-Seq_HELA_Human1.26525209
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26335897
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26281765
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25840082
98STAT3_23295773_ChIP-Seq_U87_Human1.25108102
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24490591
100* FOXH1_21741376_ChIP-Seq_EPCs_Human1.24087612
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23044420
102ELK1_19687146_ChIP-ChIP_HELA_Human1.22493002
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21921980
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21148934
105ER_23166858_ChIP-Seq_MCF-7_Human1.20226967
106* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19633607
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19076908
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17654009
109* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16365553
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15422997
111GABP_19822575_ChIP-Seq_HepG2_Human1.15363223
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15251615
113* TTF2_22483619_ChIP-Seq_HELA_Human1.14860442
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12123090
115* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11331943
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10846774
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.10245071
118TFEB_21752829_ChIP-Seq_HELA_Human1.09752903
119CHD1_26751641_Chip-Seq_LNCaP_Human1.09603612
120PKCTHETA_26484144_Chip-Seq_BREAST_Human1.09589248
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.09072045
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.08849426
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07739567
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06624041
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06465712
126RUNX2_22187159_ChIP-Seq_PCA_Human1.06366285
127AR_25329375_ChIP-Seq_VCAP_Human1.06254413
128REST_21632747_ChIP-Seq_MESCs_Mouse1.05611537
129CBP_20019798_ChIP-Seq_JUKART_Human1.05276445
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05276445
131FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04321922
132AR_20517297_ChIP-Seq_VCAP_Human1.04171520
133E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03152392
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03082015
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02635924
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02520152
137SOX2_19829295_ChIP-Seq_ESCs_Human1.00840487
138NANOG_19829295_ChIP-Seq_ESCs_Human1.00840487
139VDR_23849224_ChIP-Seq_CD4+_Human1.00713449
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00388775
141WDR5_24793694_ChIP-Seq_LNCAP_Human1.00202304
142YY1_21170310_ChIP-Seq_MESCs_Mouse1.00181110
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99166031
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.98885489
145* TCF4_23295773_ChIP-Seq_U87_Human0.98776934
146POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98423502
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98057023
148TCF7_22412390_ChIP-Seq_EML_Mouse0.97905188
149FOXP3_21729870_ChIP-Seq_TREG_Human0.97005133
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95965072
151NCOR_22424771_ChIP-Seq_293T_Human0.95571234
152PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95181393
153E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94268476
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94234257
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92991716
156TCF4_22108803_ChIP-Seq_LS180_Human0.92682402
157PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92575659
158JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92170128
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91922205
160ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91874269
161* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91820020
162* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91591036
163MYC_19829295_ChIP-Seq_ESCs_Human0.91493275
164ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91460546
165KDM2B_26808549_Chip-Seq_DND41_Human0.90719714
166CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90710960
167GATA1_26923725_Chip-Seq_HPCs_Mouse0.90273269
168NANOG_18692474_ChIP-Seq_MESCs_Mouse0.89741353
169ERA_21632823_ChIP-Seq_H3396_Human0.89684184
170PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89651097
171POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89008241
172TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88990230
173POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88990230
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88761318
175* SOX2_16153702_ChIP-ChIP_HESCs_Human0.88115512
176POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.87620684
177SMAD4_21799915_ChIP-Seq_A2780_Human0.87546144
178NFE2_27457419_Chip-Seq_LIVER_Mouse0.87423136
179* HOXB7_26014856_ChIP-Seq_BT474_Human0.87419087
180EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85268596
181RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84982379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.20960996
2MP0008995_early_reproductive_senescence5.65989455
3MP0008057_abnormal_DNA_replication3.77011463
4MP0003786_premature_aging3.67903191
5MP0010094_abnormal_chromosome_stability3.50633632
6MP0005174_abnormal_tail_pigmentation3.28867562
7* MP0002210_abnormal_sex_determination3.11918591
8MP0003111_abnormal_nucleus_morphology3.10609495
9MP0004957_abnormal_blastocyst_morpholog3.04964950
10MP0003123_paternal_imprinting2.84387127
11MP0005377_hearing/vestibular/ear_phenot2.74153043
12MP0003878_abnormal_ear_physiology2.74153043
13MP0008058_abnormal_DNA_repair2.68657953
14* MP0001145_abnormal_male_reproductive2.64279455
15* MP0001929_abnormal_gametogenesis2.57330277
16MP0003077_abnormal_cell_cycle2.54743809
17MP0004147_increased_porphyrin_level2.38334073
18MP0003693_abnormal_embryo_hatching2.33577848
19* MP0000653_abnormal_sex_gland2.27979790
20MP0006292_abnormal_olfactory_placode2.26597564
21MP0003646_muscle_fatigue2.21689157
22MP0006072_abnormal_retinal_apoptosis2.13629416
23MP0001730_embryonic_growth_arrest2.11739109
24MP0005551_abnormal_eye_electrophysiolog2.07050188
25MP0005076_abnormal_cell_differentiation1.99962476
26MP0010352_gastrointestinal_tract_polyps1.99545360
27MP0004885_abnormal_endolymph1.96111948
28MP0010307_abnormal_tumor_latency1.93901553
29* MP0003698_abnormal_male_reproductive1.92386757
30MP0000015_abnormal_ear_pigmentation1.89959476
31MP0002638_abnormal_pupillary_reflex1.82156768
32MP0003890_abnormal_embryonic-extraembry1.81610464
33MP0009379_abnormal_foot_pigmentation1.78986056
34MP0003121_genomic_imprinting1.78468167
35MP0004197_abnormal_fetal_growth/weight/1.77666726
36MP0000350_abnormal_cell_proliferation1.77428576
37MP0004043_abnormal_pH_regulation1.76609427
38MP0010368_abnormal_lymphatic_system1.76568176
39MP0005645_abnormal_hypothalamus_physiol1.76439881
40MP0009745_abnormal_behavioral_response1.74381204
41MP0003880_abnormal_central_pattern1.71724423
42MP0001188_hyperpigmentation1.70633637
43MP0008932_abnormal_embryonic_tissue1.68538820
44MP0002163_abnormal_gland_morphology1.67235358
45MP0009278_abnormal_bone_marrow1.65203524
46MP0002653_abnormal_ependyma_morphology1.63872898
47MP0002735_abnormal_chemical_nociception1.62920150
48MP0008007_abnormal_cellular_replicative1.62192840
49MP0002084_abnormal_developmental_patter1.60371366
50MP0006276_abnormal_autonomic_nervous1.59735067
51MP0001968_abnormal_touch/_nociception1.59292364
52MP0009697_abnormal_copulation1.57922281
53MP0002085_abnormal_embryonic_tissue1.55128328
54MP0003119_abnormal_digestive_system1.52635620
55MP0001672_abnormal_embryogenesis/_devel1.49613386
56MP0005380_embryogenesis_phenotype1.49613386
57MP0009046_muscle_twitch1.49063986
58MP0002095_abnormal_skin_pigmentation1.48544983
59MP0001697_abnormal_embryo_size1.42433876
60MP0000566_synostosis1.39630940
61MP0005623_abnormal_meninges_morphology1.38314521
62MP0010386_abnormal_urinary_bladder1.38024363
63MP0003315_abnormal_perineum_morphology1.37176056
64MP0002086_abnormal_extraembryonic_tissu1.34315036
65MP0005647_abnormal_sex_gland1.34073815
66MP0001485_abnormal_pinna_reflex1.33668783
67MP0002736_abnormal_nociception_after1.33460975
68MP0004142_abnormal_muscle_tone1.29488648
69MP0003984_embryonic_growth_retardation1.29162383
70MP0003787_abnormal_imprinting1.26645282
71MP0002088_abnormal_embryonic_growth/wei1.25475793
72MP0001661_extended_life_span1.25007665
73MP0001119_abnormal_female_reproductive1.23319192
74MP0002734_abnormal_mechanical_nocicepti1.23005819
75MP0005253_abnormal_eye_physiology1.21667997
76MP0002064_seizures1.21523486
77MP0004742_abnormal_vestibular_system1.20685674
78* MP0002161_abnormal_fertility/fecundity1.20104161
79MP0002938_white_spotting1.20098502
80MP0002160_abnormal_reproductive_system1.19990099
81MP0002184_abnormal_innervation1.19322061
82MP0000383_abnormal_hair_follicle1.17430440
83MP0002080_prenatal_lethality1.17118159
84MP0002138_abnormal_hepatobiliary_system1.14695581
85MP0000631_abnormal_neuroendocrine_gland1.13735001
86MP0002837_dystrophic_cardiac_calcinosis1.13467982
87MP0003705_abnormal_hypodermis_morpholog1.13194643
88MP0004233_abnormal_muscle_weight1.11169392
89MP0006035_abnormal_mitochondrial_morpho1.11145414
90MP0002751_abnormal_autonomic_nervous1.10981634
91MP0002272_abnormal_nervous_system1.10849727
92MP0001293_anophthalmia1.08700223
93MP0000537_abnormal_urethra_morphology1.07292291
94MP0001970_abnormal_pain_threshold1.07189549
95MP0005379_endocrine/exocrine_gland_phen1.05907398
96* MP0003936_abnormal_reproductive_system1.04107500
97MP0003115_abnormal_respiratory_system1.02663843
98MP0005167_abnormal_blood-brain_barrier1.02534841
99MP0009703_decreased_birth_body1.01960613
100MP0003567_abnormal_fetal_cardiomyocyte1.01333773
101MP0009672_abnormal_birth_weight1.00650245
102MP0008875_abnormal_xenobiotic_pharmacok1.00557822
103MP0000313_abnormal_cell_death0.99730915
104MP0002733_abnormal_thermal_nociception0.97479167
105MP0001727_abnormal_embryo_implantation0.97026793
106MP0001486_abnormal_startle_reflex0.95350164
107MP0001919_abnormal_reproductive_system0.94731564
108MP0000026_abnormal_inner_ear0.94575821
109MP0003136_yellow_coat_color0.94085674
110MP0000427_abnormal_hair_cycle0.94050541
111MP0002697_abnormal_eye_size0.93579504
112MP0005410_abnormal_fertilization0.93313548
113MP0002067_abnormal_sensory_capabilities0.93170305
114MP0003941_abnormal_skin_development0.93047966
115MP0008872_abnormal_physiological_respon0.92922731
116MP0003283_abnormal_digestive_organ0.92724735
117MP0004215_abnormal_myocardial_fiber0.92075119
118MP0001963_abnormal_hearing_physiology0.88642054
119MP0001529_abnormal_vocalization0.88155683
120MP0003699_abnormal_female_reproductive0.87807108
121MP0005195_abnormal_posterior_eye0.87450024
122MP0000778_abnormal_nervous_system0.87189006
123MP0001915_intracranial_hemorrhage0.86614686
124MP0002019_abnormal_tumor_incidence0.82670983
125MP0003183_abnormal_peptide_metabolism0.81115774
126MP0002752_abnormal_somatic_nervous0.79618929
127MP0000647_abnormal_sebaceous_gland0.79462113
128MP0010030_abnormal_orbit_morphology0.78280444
129MP0003937_abnormal_limbs/digits/tail_de0.77652124
130MP0002572_abnormal_emotion/affect_behav0.77286274
131MP0010234_abnormal_vibrissa_follicle0.76346600
132MP0002092_abnormal_eye_morphology0.75084238
133MP0005389_reproductive_system_phenotype0.74683581
134MP0003806_abnormal_nucleotide_metabolis0.73677508
135MP0002229_neurodegeneration0.73546510
136MP0004808_abnormal_hematopoietic_stem0.72902404
137MP0003861_abnormal_nervous_system0.72857746
138MP0002009_preneoplasia0.71708758
139MP0005670_abnormal_white_adipose0.71350906
140MP0003718_maternal_effect0.70453108
141MP0003045_fibrosis0.70353331
142MP0003195_calcinosis0.70312646
143MP0002111_abnormal_tail_morphology0.69724781
144MP0008789_abnormal_olfactory_epithelium0.69659440
145MP0009053_abnormal_anal_canal0.69538921
146MP0001324_abnormal_eye_pigmentation0.69460757
147MP0004133_heterotaxia0.68787280
148MP0003935_abnormal_craniofacial_develop0.67766190
149MP0000432_abnormal_head_morphology0.64618463
150MP0000428_abnormal_craniofacial_morphol0.63981963
151MP0004185_abnormal_adipocyte_glucose0.63256263
152MP0001545_abnormal_hematopoietic_system0.61814851
153MP0005397_hematopoietic_system_phenotyp0.61814851
154MP0005621_abnormal_cell_physiology0.59277119
155MP0003755_abnormal_palate_morphology0.55971159
156MP0002102_abnormal_ear_morphology0.54496409
157MP0000569_abnormal_digit_pigmentation0.54108495
158MP0005395_other_phenotype0.53891211
159MP0005384_cellular_phenotype0.52392962
160MP0005248_abnormal_Harderian_gland0.50617280
161MP0003942_abnormal_urinary_system0.50228307
162MP0002249_abnormal_larynx_morphology0.49787594
163MP0002114_abnormal_axial_skeleton0.49307948
164MP0006138_congestive_heart_failure0.48336191
165MP0003221_abnormal_cardiomyocyte_apopto0.48150107
166MP0001286_abnormal_eye_development0.47839006

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)5.22243948
2Azoospermia (HP:0000027)5.16758665
3Gonadal dysgenesis (HP:0000133)5.00186950
4Male infertility (HP:0003251)4.68993723
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.54408500
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.54408500
7Abnormal spermatogenesis (HP:0008669)4.50856818
8Abnormal sex determination (HP:0012244)4.13637727
9Sex reversal (HP:0012245)4.13637727
1011 pairs of ribs (HP:0000878)4.05796218
11Ependymoma (HP:0002888)3.89794792
12Abnormality of the lower motor neuron (HP:0002366)3.89641970
13Osteomalacia (HP:0002749)3.79967006
14Metaphyseal cupping (HP:0003021)3.74452876
15Abnormality of the corticospinal tract (HP:0002492)3.73687653
16Chromsome breakage (HP:0040012)3.66045842
17Hand muscle atrophy (HP:0009130)3.63213248
18Nephronophthisis (HP:0000090)3.51711232
19Congenital stationary night blindness (HP:0007642)3.48931118
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47792011
21Astrocytoma (HP:0009592)3.47030926
22Abnormality of the astrocytes (HP:0100707)3.47030926
23Neonatal short-limb short stature (HP:0008921)3.38641946
24Missing ribs (HP:0000921)3.29763267
25Medulloblastoma (HP:0002885)3.27748275
26Selective tooth agenesis (HP:0001592)3.09020777
27Chronic hepatic failure (HP:0100626)3.07369308
28Pendular nystagmus (HP:0012043)3.07257496
29Tongue fasciculations (HP:0001308)3.06169788
30Pancreatic fibrosis (HP:0100732)3.04498098
31Facial hemangioma (HP:0000329)3.02876468
32Retinal dysplasia (HP:0007973)3.02029560
33Abnormality of the labia minora (HP:0012880)3.01340539
34True hermaphroditism (HP:0010459)2.97526236
35Scotoma (HP:0000575)2.91429109
36Abnormality of the renal medulla (HP:0100957)2.90401367
37Glioma (HP:0009733)2.89008961
38Pancreatic cysts (HP:0001737)2.87170181
39Colon cancer (HP:0003003)2.86498933
40Postaxial foot polydactyly (HP:0001830)2.86366179
41Type II lissencephaly (HP:0007260)2.85928227
42Molar tooth sign on MRI (HP:0002419)2.81267098
43Abnormality of midbrain morphology (HP:0002418)2.81267098
44Abnormality of the renal collecting system (HP:0004742)2.78052608
45Abnormal rod and cone electroretinograms (HP:0008323)2.77935305
46Distal upper limb amyotrophy (HP:0007149)2.76121511
47Upper limb amyotrophy (HP:0009129)2.76121511
48Rimmed vacuoles (HP:0003805)2.74419463
49* Male pseudohermaphroditism (HP:0000037)2.73437969
50Muscle fibrillation (HP:0010546)2.73196529
51Neoplasm of the oral cavity (HP:0100649)2.71336445
52Abnormality of male internal genitalia (HP:0000022)2.70329870
53Tubular atrophy (HP:0000092)2.69145763
54Abnormality of the anterior horn cell (HP:0006802)2.67981354
55Degeneration of anterior horn cells (HP:0002398)2.67981354
56Impulsivity (HP:0100710)2.67772954
57Absent thumb (HP:0009777)2.65995657
58Rhabdomyosarcoma (HP:0002859)2.63177349
59Fair hair (HP:0002286)2.57799840
60Abnormality of cells of the erythroid lineage (HP:0012130)2.54693886
61Ectopic kidney (HP:0000086)2.54185166
62Spinal muscular atrophy (HP:0007269)2.53049140
63Neoplasm of striated muscle (HP:0009728)2.52980601
64Premature ovarian failure (HP:0008209)2.51657139
65Abnormal number of erythroid precursors (HP:0012131)2.49837269
66Pseudobulbar signs (HP:0002200)2.47943432
67Amyotrophic lateral sclerosis (HP:0007354)2.44196053
68Rib fusion (HP:0000902)2.44187672
69Proximal placement of thumb (HP:0009623)2.41765532
70Ankle contracture (HP:0006466)2.40529335
71Testicular neoplasm (HP:0010788)2.40056717
72Genetic anticipation (HP:0003743)2.37895829
73Renovascular hypertension (HP:0100817)2.35901850
74Central scotoma (HP:0000603)2.34932152
75Abnormality of the musculature of the hand (HP:0001421)2.34003686
76Absent radius (HP:0003974)2.33911526
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.33061977
78Supernumerary ribs (HP:0005815)2.31824483
79Shawl scrotum (HP:0000049)2.31666723
80Duodenal stenosis (HP:0100867)2.30276138
81Small intestinal stenosis (HP:0012848)2.30276138
82Short tibia (HP:0005736)2.26016358
83Increased nuchal translucency (HP:0010880)2.22660415
84Basal cell carcinoma (HP:0002671)2.22335542
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.20959444
86Severe visual impairment (HP:0001141)2.20882492
87Lissencephaly (HP:0001339)2.20672793
88Deviation of the thumb (HP:0009603)2.19284512
89Bile duct proliferation (HP:0001408)2.18946191
90Abnormal biliary tract physiology (HP:0012439)2.18946191
91Abnormality of chromosome stability (HP:0003220)2.18344362
92Absent forearm bone (HP:0003953)2.17737359
93Aplasia involving forearm bones (HP:0009822)2.17737359
94Urinary bladder sphincter dysfunction (HP:0002839)2.17064823
95Heterotopia (HP:0002282)2.15302795
96Synostosis of carpal bones (HP:0005048)2.14575249
97Natal tooth (HP:0000695)2.12646539
98Abnormality of the preputium (HP:0100587)2.12033379
99Intestinal fistula (HP:0100819)2.09819368
100Reticulocytopenia (HP:0001896)2.09579367
101Delayed epiphyseal ossification (HP:0002663)2.09394822
102Supernumerary bones of the axial skeleton (HP:0009144)2.08487587
103Morphological abnormality of the pyramidal tract (HP:0002062)2.08052917
104Duplicated collecting system (HP:0000081)2.08033645
105Anencephaly (HP:0002323)2.07059803
106Protruding tongue (HP:0010808)2.06444211
107Oligodactyly (HP:0012165)2.06250222
108Facial cleft (HP:0002006)2.05433454
109Abnormality of DNA repair (HP:0003254)2.05017168
110Abnormality of the duodenum (HP:0002246)2.04329361
111Triphalangeal thumb (HP:0001199)2.04276683
112Sloping forehead (HP:0000340)2.03972645
113Rectovaginal fistula (HP:0000143)2.01825467
114Rectal fistula (HP:0100590)2.01825467
115Volvulus (HP:0002580)2.01718687
116Congenital hepatic fibrosis (HP:0002612)2.00921018
117Abnormality of the fovea (HP:0000493)1.98916422
118Patellar aplasia (HP:0006443)1.98663483
119Secondary amenorrhea (HP:0000869)1.98156478
120Nephroblastoma (Wilms tumor) (HP:0002667)1.97687425
121Hyperglycinuria (HP:0003108)1.97105571
122Prominent nose (HP:0000448)1.96358599
123Urethral obstruction (HP:0000796)1.95167348
124Aplasia/hypoplasia of the humerus (HP:0006507)1.94728825
125Abnormality of the ileum (HP:0001549)1.94492957
126Meckel diverticulum (HP:0002245)1.94475857
127Ovarian neoplasm (HP:0100615)1.93593130
128Agnosia (HP:0010524)1.93062345
129Tachypnea (HP:0002789)1.92340156
130Cystic liver disease (HP:0006706)1.92292610
131Short humerus (HP:0005792)1.92142087
132Asplenia (HP:0001746)1.91831570
133Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.91728698
134Annular pancreas (HP:0001734)1.91638326
135Long eyelashes (HP:0000527)1.91478164
136Horseshoe kidney (HP:0000085)1.91393391
137Breast hypoplasia (HP:0003187)1.90655940
138Sandal gap (HP:0001852)1.89906773
139Aplasia/Hypoplasia of the patella (HP:0006498)1.89748213
140Papillary thyroid carcinoma (HP:0002895)1.89697997
141Rectal prolapse (HP:0002035)1.89661529
142Atrophy/Degeneration involving motor neurons (HP:0007373)1.88764057
143Abnormality of the vocal cords (HP:0008777)1.88394144
144Supernumerary spleens (HP:0009799)1.87583925
145Pelvic girdle muscle weakness (HP:0003749)1.87491241
146Biliary tract neoplasm (HP:0100574)1.86781446
147Shoulder girdle muscle weakness (HP:0003547)1.84216155
148Abnormality of the carotid arteries (HP:0005344)1.83416110
149Sclerocornea (HP:0000647)1.82424823
150Small hand (HP:0200055)1.82373618
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.82333224
152Clubbing of toes (HP:0100760)1.82326446
153Renal duplication (HP:0000075)1.82191470
154Generalized hypopigmentation of hair (HP:0011358)1.81319805
155Hyperacusis (HP:0010780)1.80962406
156Abnormality of the aortic arch (HP:0012303)1.80754251
157Abnormality of the fingertips (HP:0001211)1.80680885
158Abnormality of macular pigmentation (HP:0008002)1.80013498
159Overriding aorta (HP:0002623)1.79121153
160Carpal bone hypoplasia (HP:0001498)1.78228756
161Embryonal renal neoplasm (HP:0011794)1.78078198
162Cafe-au-lait spot (HP:0000957)1.77324779
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.77265509
164Gaze-evoked nystagmus (HP:0000640)1.76653980
165Abnormality of the diencephalon (HP:0010662)1.75519723
166Germ cell neoplasia (HP:0100728)1.74211043
167Polydipsia (HP:0001959)1.73762943
168Abnormal drinking behavior (HP:0030082)1.73762943
169Dyskinesia (HP:0100660)1.72706158
170Impaired vibration sensation in the lower limbs (HP:0002166)1.72035653
171Oligodactyly (hands) (HP:0001180)1.71278663
172Postaxial hand polydactyly (HP:0001162)1.70056778
173Abnormality of the renal cortex (HP:0011035)1.69618205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.89921263
2CDC74.46004602
3CDK194.02358096
4BRD43.71709935
5ACVR1B2.81401936
6ICK2.75591431
7TYRO32.70995316
8NEK22.65702718
9WEE12.63577058
10NUAK12.50236809
11WNK42.43245458
12CDK72.41390852
13ZAK2.39762048
14EPHA42.14658113
15STK392.01149655
16TLK11.97257837
17TTK1.83716951
18PLK11.79996079
19CDK41.76873385
20GRK11.67171513
21ATR1.64599453
22MKNK21.60277555
23CHEK21.57981296
24PINK11.57114763
25FRK1.55526612
26CHEK11.52521333
27CDK91.51495872
28MTOR1.48002900
29MAP3K101.42364336
30SIK21.41374222
31EPHA21.38889885
32MKNK11.38623156
33INSRR1.38402414
34WNK31.36989614
35NTRK31.35698326
36DYRK21.35034076
37PRKD31.31629914
38ADRBK21.29200793
39ATM1.28917014
40BMPR1B1.28517474
41BUB11.25720635
42MAP3K41.23636711
43MAP4K21.20862719
44SRPK11.19662882
45SCYL21.19556987
46EEF2K1.16843120
47RPS6KB21.16840260
48OXSR11.13708072
49CAMK1D1.11574901
50TNIK1.11302196
51CDK21.10004913
52LATS11.09795538
53IRAK11.08310249
54RIPK11.06170734
55PNCK1.06027156
56VRK11.04848247
57STK31.04780065
58MAPK130.99510928
59YES10.97222583
60PDK40.96693656
61PDK30.96693656
62STK40.94742672
63STK38L0.92468931
64BRSK10.91860006
65ALK0.91712616
66AURKB0.89388000
67TSSK60.89221481
68PASK0.88975112
69PAK40.88016839
70CDK10.87627364
71VRK20.84762894
72KIT0.84507937
73IRAK20.83947078
74CASK0.83561394
75MAP3K20.83246675
76CDK60.82145883
77BMX0.79932297
78LATS20.79615449
79CCNB10.79510514
80PKN20.79289624
81PDGFRA0.79139009
82MET0.78593448
83CDC42BPA0.77492917
84MELK0.75948429
85WNK10.74000242
86TIE10.73205266
87TAF10.73125052
88BRSK20.73051578
89AURKA0.72310131
90BCR0.71257246
91NEK10.70655007
92MAP3K60.69770858
93NTRK20.68423226
94PLK20.67574927
95CSNK1E0.67364113
96PRKCG0.66587594
97PRKDC0.66549543
98MAP3K70.66278326
99CDK80.65804090
100CSNK1A1L0.64590701
101PLK30.64500210
102CAMK10.61511923
103MAPK140.60366004
104CSNK1G20.59508123
105GSK3B0.59363453
106DYRK30.58583131
107PLK40.57682553
108CSNK2A20.56059151
109CSNK1D0.55565134
110CAMK1G0.55018191
111DAPK10.54486378
112MAPK10.53529021
113STK240.52546711
114PTK60.52234772
115BRAF0.51522130
116PHKG10.51452121
117PHKG20.51452121
118CHUK0.48974051
119EIF2AK30.48540007
120DDR20.47485863
121MAP2K20.46736685
122STK110.45462058
123RPS6KA60.44601802
124PAK20.42058741
125MAP3K80.41885180
126FGR0.41879285
127FGFR10.41639494
128TRIB30.41212159
129AKT10.41118701
130PDK20.41017478
131MARK30.40926812
132TXK0.40897334
133MATK0.38930116
134MST40.38166992
135PIM10.38084621
136MAPKAPK50.37437806
137DYRK1A0.37008285
138PIK3CA0.36887892
139PTK20.35468614
140MAPK100.34797938
141RPS6KB10.34528161
142CDK30.33585108
143TGFBR10.32969389
144PRKCQ0.32953144
145MAPK80.32033812
146FLT30.31831528
147STK380.31289055
148CSNK1G10.30911881
149RPS6KA10.30025123
150BCKDK0.30011457
151PRKG10.29464923
152CSNK2A10.28506401
153PRKACA0.28501609
154CAMKK10.28470502
155MAP3K90.28443933
156ADRBK10.28438701
157MAPKAPK30.27099695
158PDGFRB0.26814140
159RPS6KA50.26301172
160PAK10.26060786
161MAP3K110.24231199

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.72672501
2Mismatch repair_Homo sapiens_hsa034303.95310212
3DNA replication_Homo sapiens_hsa030303.77260213
4RNA transport_Homo sapiens_hsa030133.46706391
5Basal transcription factors_Homo sapiens_hsa030223.37069989
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.28044804
7mRNA surveillance pathway_Homo sapiens_hsa030153.04812584
8Spliceosome_Homo sapiens_hsa030403.04478308
9Cell cycle_Homo sapiens_hsa041102.86044981
10Homologous recombination_Homo sapiens_hsa034402.79683426
11Base excision repair_Homo sapiens_hsa034102.67168993
12Phototransduction_Homo sapiens_hsa047442.65377867
13Nucleotide excision repair_Homo sapiens_hsa034202.61951342
14Fanconi anemia pathway_Homo sapiens_hsa034602.53814303
15One carbon pool by folate_Homo sapiens_hsa006702.53422189
16RNA polymerase_Homo sapiens_hsa030202.43424066
17Lysine degradation_Homo sapiens_hsa003102.19355406
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08608077
19Folate biosynthesis_Homo sapiens_hsa007902.04059828
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.96202240
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91092379
22Non-homologous end-joining_Homo sapiens_hsa034501.90505342
23Nicotine addiction_Homo sapiens_hsa050331.84879246
24Oocyte meiosis_Homo sapiens_hsa041141.79451316
25Dorso-ventral axis formation_Homo sapiens_hsa043201.63704598
26Notch signaling pathway_Homo sapiens_hsa043301.63083935
27Fatty acid biosynthesis_Homo sapiens_hsa000611.61142644
28RNA degradation_Homo sapiens_hsa030181.58349489
29Regulation of autophagy_Homo sapiens_hsa041401.55727715
30TGF-beta signaling pathway_Homo sapiens_hsa043501.55443315
31Selenocompound metabolism_Homo sapiens_hsa004501.54997902
32Oxidative phosphorylation_Homo sapiens_hsa001901.53972658
33Linoleic acid metabolism_Homo sapiens_hsa005911.52331272
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40898524
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39086395
36Fatty acid elongation_Homo sapiens_hsa000621.37234973
37Hippo signaling pathway_Homo sapiens_hsa043901.30037588
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24483117
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21708438
40Hedgehog signaling pathway_Homo sapiens_hsa043401.21309114
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21258928
42Basal cell carcinoma_Homo sapiens_hsa052171.21049225
43Caffeine metabolism_Homo sapiens_hsa002321.20807027
44Pyrimidine metabolism_Homo sapiens_hsa002401.18704656
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17795142
46p53 signaling pathway_Homo sapiens_hsa041151.16172381
47Butanoate metabolism_Homo sapiens_hsa006501.15785080
48Propanoate metabolism_Homo sapiens_hsa006401.15773005
49Ether lipid metabolism_Homo sapiens_hsa005651.15683954
50Herpes simplex infection_Homo sapiens_hsa051681.10628273
51Nitrogen metabolism_Homo sapiens_hsa009101.09287225
52Small cell lung cancer_Homo sapiens_hsa052221.07549185
53Adherens junction_Homo sapiens_hsa045201.07152090
54MicroRNAs in cancer_Homo sapiens_hsa052061.03031185
55Olfactory transduction_Homo sapiens_hsa047401.02885636
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.01957161
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01453361
58Tryptophan metabolism_Homo sapiens_hsa003801.01237670
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.00463329
60Parkinsons disease_Homo sapiens_hsa050121.00275940
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99948484
62Thyroid cancer_Homo sapiens_hsa052160.99536587
63Protein export_Homo sapiens_hsa030600.98641697
64Epstein-Barr virus infection_Homo sapiens_hsa051690.97041186
65Primary immunodeficiency_Homo sapiens_hsa053400.95349944
66Huntingtons disease_Homo sapiens_hsa050160.93708311
67Viral carcinogenesis_Homo sapiens_hsa052030.92486964
68HTLV-I infection_Homo sapiens_hsa051660.90530266
69Proteasome_Homo sapiens_hsa030500.87851551
70Cardiac muscle contraction_Homo sapiens_hsa042600.87505416
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86839116
72Chemical carcinogenesis_Homo sapiens_hsa052040.86512721
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85821870
74Tight junction_Homo sapiens_hsa045300.85513805
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81642751
76mTOR signaling pathway_Homo sapiens_hsa041500.79620004
77beta-Alanine metabolism_Homo sapiens_hsa004100.78362967
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76205956
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.76142241
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75614871
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.74331834
82Systemic lupus erythematosus_Homo sapiens_hsa053220.74308527
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.72062527
84Asthma_Homo sapiens_hsa053100.71493956
85Antigen processing and presentation_Homo sapiens_hsa046120.70010702
86Arachidonic acid metabolism_Homo sapiens_hsa005900.68063484
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67703163
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.66504232
89Collecting duct acid secretion_Homo sapiens_hsa049660.66139837
90Ribosome_Homo sapiens_hsa030100.65783316
91Colorectal cancer_Homo sapiens_hsa052100.65429703
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.65091732
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.64997420
94Steroid biosynthesis_Homo sapiens_hsa001000.64648346
95Biosynthesis of amino acids_Homo sapiens_hsa012300.64044668
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63722909
97Wnt signaling pathway_Homo sapiens_hsa043100.63472551
98Morphine addiction_Homo sapiens_hsa050320.61884709
99Alzheimers disease_Homo sapiens_hsa050100.60331335
100Retinol metabolism_Homo sapiens_hsa008300.59822177
101Pathways in cancer_Homo sapiens_hsa052000.59541877
102ECM-receptor interaction_Homo sapiens_hsa045120.57592520
103Tyrosine metabolism_Homo sapiens_hsa003500.57103998
104Taste transduction_Homo sapiens_hsa047420.56819646
105Histidine metabolism_Homo sapiens_hsa003400.56806005
106ABC transporters_Homo sapiens_hsa020100.55602134
107Purine metabolism_Homo sapiens_hsa002300.54843784
108Prostate cancer_Homo sapiens_hsa052150.52930744
109Insulin secretion_Homo sapiens_hsa049110.51421999
110Metabolic pathways_Homo sapiens_hsa011000.50046246
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49544806
112Serotonergic synapse_Homo sapiens_hsa047260.48493852
113Fatty acid degradation_Homo sapiens_hsa000710.48022411
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46322930
115Alcoholism_Homo sapiens_hsa050340.45667423
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45626460
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45575306
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42590669
119Melanoma_Homo sapiens_hsa052180.42487992
120Sulfur relay system_Homo sapiens_hsa041220.41242372
121Focal adhesion_Homo sapiens_hsa045100.39992125
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38269294
123Vitamin digestion and absorption_Homo sapiens_hsa049770.38214722
124Proteoglycans in cancer_Homo sapiens_hsa052050.37954715
125Amoebiasis_Homo sapiens_hsa051460.37246373
126Calcium signaling pathway_Homo sapiens_hsa040200.36741704
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36706386
128Peroxisome_Homo sapiens_hsa041460.35735577
129Fat digestion and absorption_Homo sapiens_hsa049750.35568932
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35173438
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34077654
132Endometrial cancer_Homo sapiens_hsa052130.33651437
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31763808
134Ovarian steroidogenesis_Homo sapiens_hsa049130.31605301
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.31274497
136Viral myocarditis_Homo sapiens_hsa054160.30714665
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30339279
138Fatty acid metabolism_Homo sapiens_hsa012120.30264595
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29699633
140Bladder cancer_Homo sapiens_hsa052190.27795631
141AMPK signaling pathway_Homo sapiens_hsa041520.27550623
142Non-small cell lung cancer_Homo sapiens_hsa052230.27151977
143Pentose phosphate pathway_Homo sapiens_hsa000300.26748645
144Chronic myeloid leukemia_Homo sapiens_hsa052200.25703453
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25326638
146Influenza A_Homo sapiens_hsa051640.25046779
147Pancreatic cancer_Homo sapiens_hsa052120.24979698
148Glycerolipid metabolism_Homo sapiens_hsa005610.23981896
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23660074
150Protein digestion and absorption_Homo sapiens_hsa049740.21237811
151VEGF signaling pathway_Homo sapiens_hsa043700.20781002
152Axon guidance_Homo sapiens_hsa043600.20676905
153Acute myeloid leukemia_Homo sapiens_hsa052210.20510995
154FoxO signaling pathway_Homo sapiens_hsa040680.20270515
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19332961
156Glioma_Homo sapiens_hsa052140.13832715
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13647289
158Prion diseases_Homo sapiens_hsa050200.13392268
159ErbB signaling pathway_Homo sapiens_hsa040120.12337407
160Insulin signaling pathway_Homo sapiens_hsa049100.12074885
161Glutathione metabolism_Homo sapiens_hsa004800.10927888
162Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10877217
163Mineral absorption_Homo sapiens_hsa049780.10704164
164Inositol phosphate metabolism_Homo sapiens_hsa005620.10528782
165Renal cell carcinoma_Homo sapiens_hsa052110.10519802
166Apoptosis_Homo sapiens_hsa042100.09704012
167Choline metabolism in cancer_Homo sapiens_hsa052310.09691646
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08620092

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