DMBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.60041213
2limb bud formation (GO:0060174)4.41136994
3cerebral cortex radially oriented cell migration (GO:0021799)4.26032711
4keratinocyte development (GO:0003334)4.25447017
5superoxide anion generation (GO:0042554)4.17059928
6response to pheromone (GO:0019236)3.90582284
7positive regulation of protein kinase C signaling (GO:0090037)3.84905711
8long-chain fatty acid biosynthetic process (GO:0042759)3.73172722
9regulation of activation of Janus kinase activity (GO:0010533)3.70176552
10negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67397624
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66317501
12ATP synthesis coupled proton transport (GO:0015986)3.66317501
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61353715
14presynaptic membrane assembly (GO:0097105)3.56111931
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45413322
16protein-cofactor linkage (GO:0018065)3.42673751
17neuron cell-cell adhesion (GO:0007158)3.40000663
18detection of light stimulus involved in sensory perception (GO:0050962)3.38909020
19detection of light stimulus involved in visual perception (GO:0050908)3.38909020
20ribosomal small subunit assembly (GO:0000028)3.34018917
21positive regulation of monocyte chemotaxis (GO:0090026)3.30500428
22eosinophil chemotaxis (GO:0048245)3.28035136
23DNA deamination (GO:0045006)3.27204443
24mesenchymal cell differentiation involved in renal system development (GO:2001012)3.26885043
25mesenchymal cell differentiation involved in kidney development (GO:0072161)3.26885043
26kidney morphogenesis (GO:0060993)3.22687616
27piRNA metabolic process (GO:0034587)3.20781840
28protein complex biogenesis (GO:0070271)3.20383999
29NADH dehydrogenase complex assembly (GO:0010257)3.19826122
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19826122
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.19826122
32presynaptic membrane organization (GO:0097090)3.18426660
33electron transport chain (GO:0022900)3.18114007
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14945620
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14589980
36respiratory electron transport chain (GO:0022904)3.14071928
37regulation of cilium movement (GO:0003352)3.12064474
38fucose catabolic process (GO:0019317)3.11431119
39L-fucose metabolic process (GO:0042354)3.11431119
40L-fucose catabolic process (GO:0042355)3.11431119
41regulation of timing of cell differentiation (GO:0048505)3.10450172
42cellular ketone body metabolic process (GO:0046950)3.09834673
43eosinophil migration (GO:0072677)3.09653065
44postsynaptic membrane organization (GO:0001941)3.07967252
45meiotic chromosome segregation (GO:0045132)3.04603721
46epithelial cilium movement (GO:0003351)3.03139708
47viral transcription (GO:0019083)3.02988605
48lateral sprouting from an epithelium (GO:0060601)3.02795422
49translational termination (GO:0006415)3.02481070
50DNA damage response, detection of DNA damage (GO:0042769)3.00412447
51preassembly of GPI anchor in ER membrane (GO:0016254)2.96698586
52ketone body metabolic process (GO:1902224)2.96564597
53cranial nerve morphogenesis (GO:0021602)2.96190014
54cellular response to exogenous dsRNA (GO:0071360)2.95374592
55retina layer formation (GO:0010842)2.94467589
56urogenital system development (GO:0001655)2.93995553
57axon ensheathment in central nervous system (GO:0032291)2.91895116
58central nervous system myelination (GO:0022010)2.91895116
59mitochondrial respiratory chain complex assembly (GO:0033108)2.91495712
60spinal cord motor neuron differentiation (GO:0021522)2.90529271
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.89781557
62positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86814921
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85508837
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84626724
65tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84626724
66cotranslational protein targeting to membrane (GO:0006613)2.83948019
67pyrimidine nucleobase catabolic process (GO:0006208)2.83145991
68synapsis (GO:0007129)2.82346717
69pseudouridine synthesis (GO:0001522)2.81521193
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.80023894
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.79553259
72regulation of meiosis I (GO:0060631)2.79485388
73daunorubicin metabolic process (GO:0044597)2.78567808
74polyketide metabolic process (GO:0030638)2.78567808
75doxorubicin metabolic process (GO:0044598)2.78567808
76negative regulation of exocytosis (GO:0045920)2.78294578
77replication fork processing (GO:0031297)2.76714191
78DNA integration (GO:0015074)2.76342285
79negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.76203471
80neural tube formation (GO:0001841)2.75752557
81regulation of glucokinase activity (GO:0033131)2.75710422
82regulation of hexokinase activity (GO:1903299)2.75710422
83respiratory chain complex IV assembly (GO:0008535)2.75481176
84platelet dense granule organization (GO:0060155)2.74229598
85protein targeting to ER (GO:0045047)2.73414041
86positive regulation of gastrulation (GO:2000543)2.72987588
87somite rostral/caudal axis specification (GO:0032525)2.71735272
88nonmotile primary cilium assembly (GO:0035058)2.70553534
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70400077
90neuron recognition (GO:0008038)2.70252689
91cell differentiation in spinal cord (GO:0021515)2.69173115
92regulation of development, heterochronic (GO:0040034)2.68243150
93monocyte chemotaxis (GO:0002548)2.66479371
94positive regulation of action potential (GO:0045760)2.66340002
95translational elongation (GO:0006414)2.65924377
96mannosylation (GO:0097502)2.65626760
97resolution of meiotic recombination intermediates (GO:0000712)2.64785744
98reciprocal DNA recombination (GO:0035825)2.63959794
99reciprocal meiotic recombination (GO:0007131)2.63959794
100regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.63166923
101cytochrome complex assembly (GO:0017004)2.63116894
102photoreceptor cell development (GO:0042461)2.62563916
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.62518416
104intraciliary transport (GO:0042073)2.60979481
105glutamate receptor signaling pathway (GO:0007215)2.60461975
106protein K6-linked ubiquitination (GO:0085020)2.59876452
107regulation of nuclear cell cycle DNA replication (GO:0033262)2.59264551
108behavioral response to ethanol (GO:0048149)2.58835979
109positive regulation of synapse assembly (GO:0051965)2.58703130
110protein localization to endoplasmic reticulum (GO:0070972)2.58438253
111regulation of inositol phosphate biosynthetic process (GO:0010919)2.58317085
112DNA methylation involved in gamete generation (GO:0043046)2.58151939
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57194285
114C4-dicarboxylate transport (GO:0015740)2.56794845
115positive regulation of oligodendrocyte differentiation (GO:0048714)2.54979686
116photoreceptor cell maintenance (GO:0045494)2.54947737
117positive regulation of interleukin-1 beta secretion (GO:0050718)2.54935613
118spliceosomal complex assembly (GO:0000245)2.54467926
119recombinational repair (GO:0000725)2.53995888
120ncRNA catabolic process (GO:0034661)2.53979175
121reflex (GO:0060004)2.53923944
122negative regulation of homotypic cell-cell adhesion (GO:0034111)2.53820459
123regulation of collateral sprouting (GO:0048670)2.53651840
124cerebral cortex cell migration (GO:0021795)2.53260734
125spinal cord association neuron differentiation (GO:0021527)2.53199213
126GPI anchor metabolic process (GO:0006505)2.52293191
127ubiquinone metabolic process (GO:0006743)2.52000304
128ubiquinone biosynthetic process (GO:0006744)2.51745168
129thalamus development (GO:0021794)2.51448543
130double-strand break repair via homologous recombination (GO:0000724)2.51444753
131spliceosomal snRNP assembly (GO:0000387)2.51418955
132centriole replication (GO:0007099)2.51325170
133developmental pigmentation (GO:0048066)2.50475018
134negative regulation of stem cell proliferation (GO:2000647)2.50125043
135neuron fate determination (GO:0048664)2.48877535
136protein neddylation (GO:0045116)2.48739763
137proline transport (GO:0015824)2.47434827
138ATP biosynthetic process (GO:0006754)2.47407129
139nucleotide transmembrane transport (GO:1901679)2.46870749
140righting reflex (GO:0060013)2.46190828
141nucleobase catabolic process (GO:0046113)2.45214563
142L-amino acid import (GO:0043092)2.45182193
143microtubule depolymerization (GO:0007019)2.45027805
144GMP metabolic process (GO:0046037)2.44965827
145protein K11-linked deubiquitination (GO:0035871)2.44829140
146axonal fasciculation (GO:0007413)2.44773430
147kynurenine metabolic process (GO:0070189)2.44361672
148neutrophil activation (GO:0042119)2.44087004
149positive regulation of smooth muscle cell migration (GO:0014911)2.43756393
150histone-serine phosphorylation (GO:0035404)2.42805330
151cilium morphogenesis (GO:0060271)2.42730302
152sympathetic nervous system development (GO:0048485)2.42560444
153prenylation (GO:0097354)2.42480006
154protein prenylation (GO:0018342)2.42480006
155ionotropic glutamate receptor signaling pathway (GO:0035235)2.41938112
156neutrophil activation involved in immune response (GO:0002283)2.40535663
157cornea development in camera-type eye (GO:0061303)2.40053077
158cell proliferation in forebrain (GO:0021846)2.39367183
159negative regulation of mast cell activation (GO:0033004)2.39122122
160indolalkylamine catabolic process (GO:0046218)2.38830554
161startle response (GO:0001964)2.38594944
162organ growth (GO:0035265)2.38165595
163positive regulation of cellular amide metabolic process (GO:0034250)2.37488209
164regulation of platelet aggregation (GO:0090330)2.36741678
165negative regulation of neurotransmitter transport (GO:0051589)2.36436059
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.35372864
167inner ear receptor stereocilium organization (GO:0060122)2.33781017
168positive regulation of lymphocyte migration (GO:2000403)2.33462565
169positive regulation of meiotic cell cycle (GO:0051446)2.33363377
170microglial cell activation (GO:0001774)2.33162481
171negative regulation of protein localization to cell surface (GO:2000009)2.32766333
172positive regulation of interleukin-1 secretion (GO:0050716)2.32061511
173otic vesicle formation (GO:0030916)2.31923731
174pyrimidine dimer repair (GO:0006290)2.31568522
175regulation of interleukin-1 beta secretion (GO:0050706)2.31533365
176forebrain neuron development (GO:0021884)2.29790296
177regulation of somitogenesis (GO:0014807)2.29549046
178regulation of fever generation (GO:0031620)2.27626043
179regulation of synapse assembly (GO:0051963)2.27303131
180detection of molecule of bacterial origin (GO:0032490)2.27289821
181positive regulation of cAMP-mediated signaling (GO:0043950)2.27097446
182positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.26652926
183establishment of planar polarity (GO:0001736)2.26329636
184establishment of tissue polarity (GO:0007164)2.26329636
185positive regulation of meiosis (GO:0045836)2.25082916
186extracellular negative regulation of signal transduction (GO:1900116)2.24838272
187extracellular regulation of signal transduction (GO:1900115)2.24838272
188cranial nerve structural organization (GO:0021604)2.24754224
189mesenchymal cell differentiation (GO:0048762)2.24129419
190central nervous system projection neuron axonogenesis (GO:0021952)2.23906589
191G-protein coupled receptor internalization (GO:0002031)2.22456039
192protein heterotetramerization (GO:0051290)2.21871530
193transmission of nerve impulse (GO:0019226)2.21606917
194detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.20791343
195negative regulation of neurotransmitter secretion (GO:0046929)2.20342813
196cellular anion homeostasis (GO:0030002)2.19645939
197positive regulation of T cell migration (GO:2000406)2.19223504
198granulocyte activation (GO:0036230)2.18848049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.70148123
2ZNF274_21170338_ChIP-Seq_K562_Hela3.53282640
3EZH2_22144423_ChIP-Seq_EOC_Human3.40477570
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31268976
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.05633293
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.02171997
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00556728
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.95754476
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.88186347
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83086268
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.67027138
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65541192
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59922988
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.56034392
15* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.52603596
16* EZH2_27304074_Chip-Seq_ESCs_Mouse2.50893804
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32016781
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30389253
19VDR_22108803_ChIP-Seq_LS180_Human2.17189816
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15646251
21* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12804535
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10414585
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08323635
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.07071604
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03304266
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.01873204
27MYC_18940864_ChIP-ChIP_HL60_Human2.01706263
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99647293
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.95994877
30P300_19829295_ChIP-Seq_ESCs_Human1.95362613
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92575168
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90114429
33* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89575851
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.89546848
35* RNF2_27304074_Chip-Seq_NSC_Mouse1.88739860
36* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88440792
37* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88440792
38IGF1R_20145208_ChIP-Seq_DFB_Human1.88213690
39TAF15_26573619_Chip-Seq_HEK293_Human1.87651580
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.87360418
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.86780137
42AR_21572438_ChIP-Seq_LNCaP_Human1.84829802
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.83961247
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83887779
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83321387
46* RNF2_27304074_Chip-Seq_ESCs_Mouse1.82374380
47ELK1_19687146_ChIP-ChIP_HELA_Human1.81153359
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77881255
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76339633
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76273200
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.76146629
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75356500
53VDR_23849224_ChIP-Seq_CD4+_Human1.74065161
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.72936524
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71984298
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70343946
57SUZ12_18555785_Chip-Seq_ESCs_Mouse1.69607009
58* EZH2_27294783_Chip-Seq_ESCs_Mouse1.68628233
59P53_22387025_ChIP-Seq_ESCs_Mouse1.68398610
60* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66692130
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.65283631
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65268480
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64134939
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63941185
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.63743362
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.63385441
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62679158
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62452256
69TP53_22573176_ChIP-Seq_HFKS_Human1.60951192
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59695115
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.59508493
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.57990615
73NMYC_18555785_Chip-Seq_ESCs_Mouse1.57713388
74P300_18555785_Chip-Seq_ESCs_Mouse1.56046918
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55856623
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55771868
77ER_23166858_ChIP-Seq_MCF-7_Human1.54867591
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54616929
79FUS_26573619_Chip-Seq_HEK293_Human1.49864201
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49650827
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.49311274
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.49118642
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.49059147
84* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47704724
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46865556
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46368977
87* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.44868905
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44546731
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43232793
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.42566531
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.42415931
92FOXP3_21729870_ChIP-Seq_TREG_Human1.39953812
93REST_21632747_ChIP-Seq_MESCs_Mouse1.39664175
94KLF4_18555785_Chip-Seq_ESCs_Mouse1.39522617
95PU1_27457419_Chip-Seq_LIVER_Mouse1.38549553
96* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38248867
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37636688
98* ZFX_18555785_Chip-Seq_ESCs_Mouse1.37401399
99* SMAD4_21799915_ChIP-Seq_A2780_Human1.37144099
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36215660
101CBP_20019798_ChIP-Seq_JUKART_Human1.36215660
102TP53_18474530_ChIP-ChIP_U2OS_Human1.35803403
103ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32050753
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29567148
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29009127
106* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28287645
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28108827
108SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26645202
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25918589
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.25771038
111EWS_26573619_Chip-Seq_HEK293_Human1.24854144
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23741265
113SOX2_19829295_ChIP-Seq_ESCs_Human1.23200103
114NANOG_19829295_ChIP-Seq_ESCs_Human1.23200103
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20863855
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20863855
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.19772166
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19772166
119BCAT_22108803_ChIP-Seq_LS180_Human1.18245040
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17149307
121* NCOR_22424771_ChIP-Seq_293T_Human1.16996556
122* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16567588
123RUNX2_22187159_ChIP-Seq_PCA_Human1.15669117
124AR_25329375_ChIP-Seq_VCAP_Human1.14824611
125IRF8_21731497_ChIP-ChIP_J774_Mouse1.14150246
126TTF2_22483619_ChIP-Seq_HELA_Human1.13652285
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12284459
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11517989
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.10592946
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10417251
131PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10309398
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10102113
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09467706
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09463764
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08968806
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08962170
137* TCF4_22108803_ChIP-Seq_LS180_Human1.08516175
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.07390844
139IRF1_19129219_ChIP-ChIP_H3396_Human1.06564000
140IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04189844
141HOXB7_26014856_ChIP-Seq_BT474_Human1.03689524
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03020579
143TAL1_26923725_Chip-Seq_HPCs_Mouse1.02809127
144GATA3_21878914_ChIP-Seq_MCF-7_Human1.02611038
145FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01896339
146AR_20517297_ChIP-Seq_VCAP_Human1.01138973
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00436044
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99153380
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.98823925
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98253070
151HTT_18923047_ChIP-ChIP_STHdh_Human0.95576337
152* TCF4_23295773_ChIP-Seq_U87_Human0.94906589
153CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94699612
154* STAT3_23295773_ChIP-Seq_U87_Human0.94326647
155AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92819551
156REST_18959480_ChIP-ChIP_MESCs_Mouse0.91844383
157FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91308479
158ERA_21632823_ChIP-Seq_H3396_Human0.91060959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.28237567
2MP0003880_abnormal_central_pattern3.88753858
3MP0005171_absent_coat_pigmentation3.84125035
4MP0002102_abnormal_ear_morphology3.67201975
5MP0001188_hyperpigmentation3.42085390
6MP0006292_abnormal_olfactory_placode3.38277168
7MP0000566_synostosis3.01070859
8MP0000569_abnormal_digit_pigmentation2.75572548
9MP0004742_abnormal_vestibular_system2.45398036
10MP0002277_abnormal_respiratory_mucosa2.33540528
11MP0005645_abnormal_hypothalamus_physiol2.31453832
12MP0008260_abnormal_autophagy2.21719600
13MP0002876_abnormal_thyroid_physiology2.09059815
14MP0001346_abnormal_lacrimal_gland2.07809425
15MP0008877_abnormal_DNA_methylation2.03748074
16MP0004885_abnormal_endolymph1.99748432
17MP0002837_dystrophic_cardiac_calcinosis1.91186632
18MP0001986_abnormal_taste_sensitivity1.90661022
19MP0002163_abnormal_gland_morphology1.90244562
20MP0002234_abnormal_pharynx_morphology1.81651002
21MP0009046_muscle_twitch1.81031271
22MP0001486_abnormal_startle_reflex1.75924880
23MP0003938_abnormal_ear_development1.75677045
24MP0005423_abnormal_somatic_nervous1.74675947
25MP0004381_abnormal_hair_follicle1.73259385
26MP0005409_darkened_coat_color1.73129397
27MP0010386_abnormal_urinary_bladder1.72770746
28MP0000026_abnormal_inner_ear1.72002560
29MP0004133_heterotaxia1.71130472
30MP0000383_abnormal_hair_follicle1.67840963
31MP0003693_abnormal_embryo_hatching1.67488663
32MP0000372_irregular_coat_pigmentation1.66818239
33MP0003195_calcinosis1.66708234
34MP0000778_abnormal_nervous_system1.64143680
35MP0003890_abnormal_embryonic-extraembry1.61867955
36MP0002148_abnormal_hypersensitivity_rea1.58945961
37MP0001968_abnormal_touch/_nociception1.58448651
38MP0005379_endocrine/exocrine_gland_phen1.57699032
39MP0000015_abnormal_ear_pigmentation1.55537300
40MP0002736_abnormal_nociception_after1.53346164
41MP0002638_abnormal_pupillary_reflex1.50208820
42MP0001501_abnormal_sleep_pattern1.48678961
43MP0006276_abnormal_autonomic_nervous1.48539266
44MP0002735_abnormal_chemical_nociception1.47855129
45MP0008875_abnormal_xenobiotic_pharmacok1.47499110
46MP0008872_abnormal_physiological_respon1.46579292
47MP0002938_white_spotting1.39489238
48MP0002249_abnormal_larynx_morphology1.39122616
49MP0003941_abnormal_skin_development1.38264055
50MP0005646_abnormal_pituitary_gland1.38236277
51MP0009745_abnormal_behavioral_response1.37865123
52MP0001963_abnormal_hearing_physiology1.36812624
53MP0005075_abnormal_melanosome_morpholog1.29529863
54MP0002064_seizures1.29296790
55MP0002272_abnormal_nervous_system1.27281014
56MP0001485_abnormal_pinna_reflex1.25783391
57MP0009379_abnormal_foot_pigmentation1.25193011
58MP0003646_muscle_fatigue1.24130222
59MP0002653_abnormal_ependyma_morphology1.23863890
60MP0003011_delayed_dark_adaptation1.22855278
61MP0002095_abnormal_skin_pigmentation1.22771804
62MP0002572_abnormal_emotion/affect_behav1.16134452
63MP0001502_abnormal_circadian_rhythm1.15459048
64MP0008789_abnormal_olfactory_epithelium1.14999890
65MP0003635_abnormal_synaptic_transmissio1.14126729
66MP0001984_abnormal_olfaction1.13706861
67MP0001293_anophthalmia1.13146996
68MP0004142_abnormal_muscle_tone1.12930377
69MP0002557_abnormal_social/conspecific_i1.11911078
70MP0002067_abnormal_sensory_capabilities1.10294959
71MP0002184_abnormal_innervation1.09445114
72MP0003724_increased_susceptibility_to1.09067295
73MP0000681_abnormal_thyroid_gland1.08096154
74MP0004147_increased_porphyrin_level1.06741963
75MP0002210_abnormal_sex_determination1.06512468
76MP0001440_abnormal_grooming_behavior1.05977178
77MP0002063_abnormal_learning/memory/cond1.04354531
78MP0005195_abnormal_posterior_eye1.03854605
79MP0001929_abnormal_gametogenesis1.03657333
80MP0001324_abnormal_eye_pigmentation1.03534085
81MP0000049_abnormal_middle_ear1.03037654
82MP0003698_abnormal_male_reproductive1.02779964
83MP0003121_genomic_imprinting1.02010215
84MP0008057_abnormal_DNA_replication1.01023206
85MP0005551_abnormal_eye_electrophysiolog1.00884437
86MP0005310_abnormal_salivary_gland1.00344093
87MP0005451_abnormal_body_composition0.99106417
88MP0003283_abnormal_digestive_organ0.97696448
89MP0006082_CNS_inflammation0.96071690
90MP0003787_abnormal_imprinting0.95648705
91MP0001764_abnormal_homeostasis0.95278077
92MP0003315_abnormal_perineum_morphology0.95191455
93MP0000516_abnormal_urinary_system0.94557496
94MP0005367_renal/urinary_system_phenotyp0.94557496
95MP0009250_abnormal_appendicular_skeleto0.94545249
96MP0000762_abnormal_tongue_morphology0.94115023
97MP0002160_abnormal_reproductive_system0.93206269
98MP0003718_maternal_effect0.92643416
99MP0002098_abnormal_vibrissa_morphology0.92444996
100MP0002734_abnormal_mechanical_nocicepti0.92092760
101MP0008058_abnormal_DNA_repair0.92080997
102MP0005084_abnormal_gallbladder_morpholo0.92058131
103MP0005253_abnormal_eye_physiology0.91747825
104MP0003119_abnormal_digestive_system0.90905960
105MP0001835_abnormal_antigen_presentation0.90255527
106MP0004782_abnormal_surfactant_physiolog0.89939946
107MP0009785_altered_susceptibility_to0.89263584
108MP0004043_abnormal_pH_regulation0.88989201
109MP0005391_vision/eye_phenotype0.88838191
110MP0010678_abnormal_skin_adnexa0.88331509
111MP0000631_abnormal_neuroendocrine_gland0.88213122
112MP0006035_abnormal_mitochondrial_morpho0.88044656
113MP0004924_abnormal_behavior0.87761964
114MP0005386_behavior/neurological_phenoty0.87761964
115MP0008995_early_reproductive_senescence0.87418371
116MP0002822_catalepsy0.87223982
117MP0000653_abnormal_sex_gland0.86864148
118MP0000647_abnormal_sebaceous_gland0.86114580
119MP0005394_taste/olfaction_phenotype0.85483781
120MP0005499_abnormal_olfactory_system0.85483781
121MP0002752_abnormal_somatic_nervous0.85470972
122MP0005410_abnormal_fertilization0.85123780
123MP0002090_abnormal_vision0.84451854
124MP0010094_abnormal_chromosome_stability0.83789500
125MP0002928_abnormal_bile_duct0.83768041
126MP0003137_abnormal_impulse_conducting0.83022652
127MP0001145_abnormal_male_reproductive0.83012272
128MP0001970_abnormal_pain_threshold0.79154875
129MP0001542_abnormal_bone_strength0.78599195
130MP0002132_abnormal_respiratory_system0.78526183
131MP0005174_abnormal_tail_pigmentation0.77892084
132MP0003937_abnormal_limbs/digits/tail_de0.77399385
133MP0002177_abnormal_outer_ear0.75122960
134MP0002733_abnormal_thermal_nociception0.73180467
135MP0003879_abnormal_hair_cell0.73158050
136MP0001529_abnormal_vocalization0.73114362
137MP0003878_abnormal_ear_physiology0.72843175
138MP0005377_hearing/vestibular/ear_phenot0.72843175
139MP0003690_abnormal_glial_cell0.72707743
140MP0001905_abnormal_dopamine_level0.72364222
141MP0002751_abnormal_autonomic_nervous0.72274626
142MP0005248_abnormal_Harderian_gland0.70430849
143MP0008004_abnormal_stomach_pH0.68182704
144MP0006072_abnormal_retinal_apoptosis0.68098483
145MP0002419_abnormal_innate_immunity0.65516998

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.04530384
2Septo-optic dysplasia (HP:0100842)4.04016929
3White forelock (HP:0002211)3.51485918
4Acute necrotizing encephalopathy (HP:0006965)3.47634185
5Chromsome breakage (HP:0040012)3.43697215
6Absent/shortened dynein arms (HP:0200106)3.29402545
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.29402545
8Patchy hypopigmentation of hair (HP:0011365)3.25480699
9Acute encephalopathy (HP:0006846)3.25029935
10Nephronophthisis (HP:0000090)3.22148214
11Focal motor seizures (HP:0011153)3.16100868
12Abnormality of midbrain morphology (HP:0002418)3.13268298
13Molar tooth sign on MRI (HP:0002419)3.13268298
14Duplicated collecting system (HP:0000081)3.11039503
15Parakeratosis (HP:0001036)3.10538757
16Abnormal rod and cone electroretinograms (HP:0008323)3.06502507
17Mitochondrial inheritance (HP:0001427)3.01696928
18Increased IgM level (HP:0003496)2.98793704
19Abnormality of the renal cortex (HP:0011035)2.98786229
20Abnormal mitochondria in muscle tissue (HP:0008316)2.97192452
21Abnormal number of erythroid precursors (HP:0012131)2.94472700
22Type II lissencephaly (HP:0007260)2.93845340
23Progressive macrocephaly (HP:0004481)2.92411933
24Absent septum pellucidum (HP:0001331)2.87663434
25Increased CSF lactate (HP:0002490)2.87100345
26Renal cortical cysts (HP:0000803)2.85948389
27Congenital sensorineural hearing impairment (HP:0008527)2.85344973
28Hepatic necrosis (HP:0002605)2.80092479
29Abnormality of the renal medulla (HP:0100957)2.79387347
30Aplasia cutis congenita (HP:0001057)2.76783995
31Abnormal ciliary motility (HP:0012262)2.76342274
32Conical tooth (HP:0000698)2.75728129
33Prolonged neonatal jaundice (HP:0006579)2.73812889
34Optic disc pallor (HP:0000543)2.73410415
35Abnormality of the renal collecting system (HP:0004742)2.63948139
36Attenuation of retinal blood vessels (HP:0007843)2.63306715
37Abnormality of cells of the erythroid lineage (HP:0012130)2.63002194
38Abnormality of incisor morphology (HP:0011063)2.62021455
39Abnormal respiratory motile cilium morphology (HP:0005938)2.61893783
40Abnormal respiratory epithelium morphology (HP:0012253)2.61893783
41Hepatocellular necrosis (HP:0001404)2.61429415
42Cystic liver disease (HP:0006706)2.53568508
43Abnormality of the septum pellucidum (HP:0007375)2.53074598
44Hypoplasia of the pons (HP:0012110)2.51127439
45Sclerocornea (HP:0000647)2.49355951
46Prostate neoplasm (HP:0100787)2.49059886
47Optic nerve hypoplasia (HP:0000609)2.48385502
48Hyperglycinuria (HP:0003108)2.47802922
49Pendular nystagmus (HP:0012043)2.46531157
50Reticulocytopenia (HP:0001896)2.46483775
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45787864
52Duplication of thumb phalanx (HP:0009942)2.43375312
533-Methylglutaconic aciduria (HP:0003535)2.39418838
54Osteomalacia (HP:0002749)2.38702379
55Aplasia/Hypoplasia of the fovea (HP:0008060)2.38442045
56Hypoplasia of the fovea (HP:0007750)2.38442045
57Abnormality of the pons (HP:0007361)2.36823918
58Constricted visual fields (HP:0001133)2.35665827
59Cerebellar dysplasia (HP:0007033)2.33571761
60Pancreatic fibrosis (HP:0100732)2.33215997
61Decreased central vision (HP:0007663)2.26754888
62Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25459007
63Epileptic encephalopathy (HP:0200134)2.25317200
64Febrile seizures (HP:0002373)2.24761160
65Lissencephaly (HP:0001339)2.24050345
66Methylmalonic acidemia (HP:0002912)2.23087506
67True hermaphroditism (HP:0010459)2.22732195
68Cerebral edema (HP:0002181)2.21333579
69Congenital, generalized hypertrichosis (HP:0004540)2.19663608
70Hyperglycinemia (HP:0002154)2.17904265
71Amelogenesis imperfecta (HP:0000705)2.17778281
72Anencephaly (HP:0002323)2.13955185
73Absent thumb (HP:0009777)2.12415954
74Hypothermia (HP:0002045)2.10158186
75Absent radius (HP:0003974)2.09229926
76Aplasia of the musculature (HP:0100854)2.09128728
77Abnormal respiratory motile cilium physiology (HP:0012261)2.08389371
78Volvulus (HP:0002580)2.07918864
79Tubular atrophy (HP:0000092)2.07325951
80Bony spicule pigmentary retinopathy (HP:0007737)2.06473665
81Metaphyseal dysplasia (HP:0100255)2.06377396
82Abnormality of the axillary hair (HP:0100134)2.06358290
83Abnormality of secondary sexual hair (HP:0009888)2.06358290
84Preaxial hand polydactyly (HP:0001177)2.06198776
85Congenital hepatic fibrosis (HP:0002612)2.06075862
86Recurrent abscess formation (HP:0002722)2.02771190
87Retrobulbar optic neuritis (HP:0100654)2.02382493
88Optic neuritis (HP:0100653)2.02382493
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02169922
90Chronic obstructive pulmonary disease (HP:0006510)2.02058880
91Obstructive lung disease (HP:0006536)2.02058880
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.00081996
93Aplasia involving forearm bones (HP:0009822)1.98817615
94Absent forearm bone (HP:0003953)1.98817615
95Short middle phalanx of the 5th finger (HP:0004220)1.98397235
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.98030429
97Abolished electroretinogram (ERG) (HP:0000550)1.96413530
98Gait imbalance (HP:0002141)1.96086907
99Morphological abnormality of the middle ear (HP:0008609)1.95934800
100Recurrent pneumonia (HP:0006532)1.95249366
101Congenital primary aphakia (HP:0007707)1.94946785
102Male pseudohermaphroditism (HP:0000037)1.94759235
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94560914
104Intestinal atresia (HP:0011100)1.94529547
105Anophthalmia (HP:0000528)1.94278796
106Increased serum lactate (HP:0002151)1.93258345
107Broad-based gait (HP:0002136)1.90456286
108Congenital stationary night blindness (HP:0007642)1.89796663
109Nephrogenic diabetes insipidus (HP:0009806)1.89533628
110Xerostomia (HP:0000217)1.88958241
111Adrenal hypoplasia (HP:0000835)1.88913540
112Generalized aminoaciduria (HP:0002909)1.88669548
113Submucous cleft hard palate (HP:0000176)1.88250596
114Fetal akinesia sequence (HP:0001989)1.88056893
115Colon cancer (HP:0003003)1.87984775
116Postaxial foot polydactyly (HP:0001830)1.86997770
117Overfolded helix (HP:0000396)1.86721898
118Bile duct proliferation (HP:0001408)1.86119943
119Abnormal biliary tract physiology (HP:0012439)1.86119943
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.85833593
121Type I transferrin isoform profile (HP:0003642)1.85639167
122Upper limb muscle weakness (HP:0003484)1.85632695
123Short tibia (HP:0005736)1.85313187
124Aplasia involving bones of the upper limbs (HP:0009823)1.85261618
125Aplasia of the phalanges of the hand (HP:0009802)1.85261618
126Aplasia involving bones of the extremities (HP:0009825)1.85261618
127Abnormality of glycine metabolism (HP:0010895)1.84738670
128Abnormality of serine family amino acid metabolism (HP:0010894)1.84738670
129Abnormality of the labia minora (HP:0012880)1.84497422
130Abnormality of the phalanges of the 5th finger (HP:0004213)1.83585374
131Lactic acidosis (HP:0003128)1.83437688
132Ectopic kidney (HP:0000086)1.82886607
133Nasolacrimal duct obstruction (HP:0000579)1.81880210
134Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81498998
135Rib fusion (HP:0000902)1.80176555
136Increased hepatocellular lipid droplets (HP:0006565)1.79030140
137Mixed hearing impairment (HP:0000410)1.78693989
138Pachygyria (HP:0001302)1.78644933
139Abnormal drinking behavior (HP:0030082)1.78162169
140Polydipsia (HP:0001959)1.78162169
141Methylmalonic aciduria (HP:0012120)1.77378165
142Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77190763
143Abnormality of the fovea (HP:0000493)1.77013865
144Increased corneal curvature (HP:0100692)1.76903018
145Keratoconus (HP:0000563)1.76903018
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76274666
147Recurrent corneal erosions (HP:0000495)1.75641153
148Hypomagnesemia (HP:0002917)1.75120307
149Concave nail (HP:0001598)1.73838692
150Abnormality of the preputium (HP:0100587)1.73686127
151Respiratory failure (HP:0002878)1.73047376
152Furrowed tongue (HP:0000221)1.72953111
153Abnormality of the lacrimal duct (HP:0011481)1.72887996
154Short clavicles (HP:0000894)1.72497679
155Bilateral microphthalmos (HP:0007633)1.72494239
156Renal agenesis (HP:0000104)1.71838548
157Anhidrosis (HP:0000970)1.71463628
158Myelomeningocele (HP:0002475)1.71348753
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.70067208
160Severe muscular hypotonia (HP:0006829)1.69988071
161Disproportionate short-trunk short stature (HP:0003521)1.69915366
162Meckel diverticulum (HP:0002245)1.69498939
163Abnormal sex determination (HP:0012244)1.69471495
164Sex reversal (HP:0012245)1.69471495
165Pancreatic cysts (HP:0001737)1.69270411
166Cupped ear (HP:0000378)1.69232878
167Abnormality of DNA repair (HP:0003254)1.68932071
168Absent eyebrow (HP:0002223)1.68847075
169Lethargy (HP:0001254)1.68380318
170Polyuria (HP:0000103)1.66181869
171Lipid accumulation in hepatocytes (HP:0006561)1.65595651
172Recurrent bacterial skin infections (HP:0005406)1.65497702
173Aplasia/hypoplasia of the uterus (HP:0008684)1.64832197
174Abnormality of molar morphology (HP:0011070)1.64666536
175Abnormality of molar (HP:0011077)1.64666536
176Abnormality of the incisor (HP:0000676)1.64577958
177Hypoglycemic coma (HP:0001325)1.64221335
178Abnormality of the ileum (HP:0001549)1.62395275
179Patellar aplasia (HP:0006443)1.61896110
180Corneal dystrophy (HP:0001131)1.60892859
181Abnormality of dental color (HP:0011073)1.60269083
182Medial flaring of the eyebrow (HP:0010747)1.60094721

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.58034095
2BLK3.83745414
3FRK3.57646059
4MKNK23.18297865
5MAP4K23.03921607
6VRK22.97434141
7TNIK2.85455883
8PBK2.81779570
9MAP3K142.63597791
10STK162.30907420
11MAP3K92.28980310
12TLK12.10055056
13PINK12.00741740
14EPHA41.95220857
15PRPF4B1.92492338
16MKNK11.91709269
17BCR1.88853959
18EIF2AK21.82330361
19AKT31.78497633
20BMPR21.78269963
21IRAK31.76874851
22NEK11.67027693
23GRK71.66419438
24BCKDK1.65388893
25IRAK41.64341789
26GRK11.61054492
27MAPK131.58896510
28NUAK11.52596810
29EPHB21.49120343
30MST41.48083482
31NEK61.46106018
32TAF11.44453728
33SIK31.43602578
34NTRK31.43380231
35RIPK41.41887324
36MUSK1.41227483
37ADRBK21.40591925
38YES11.39865665
39PKN11.34757188
40TAOK31.32474977
41PASK1.29297597
42INSRR1.28037790
43ZAK1.27675416
44BMPR1B1.27327299
45MARK11.24265603
46MAP2K71.22095467
47PHKG21.18682072
48PHKG11.18682072
49GRK51.13403532
50TRIM281.13194905
51PLK21.12685957
52STK38L1.11293317
53TXK1.11213792
54MAP3K41.10086820
55STK391.06957901
56OXSR11.03498228
57BRSK21.00447584
58IRAK20.96809321
59NEK20.95204296
60CDK30.95072271
61IKBKB0.92339062
62ERBB30.92197943
63IRAK10.92074400
64PRKCE0.91183282
65BRD40.89238295
66FGR0.85855735
67WEE10.85602302
68MAP3K130.84207693
69PAK30.83440185
70DYRK1A0.83275434
71EPHA30.79767600
72TGFBR10.78802227
73FGFR20.73311484
74STK240.73177773
75SIK20.73035254
76MAPKAPK50.72201191
77CSNK1G30.72075986
78CSNK1G10.69257678
79DYRK20.68804144
80PRKCI0.67709774
81CHEK20.67041218
82NTRK20.66961183
83PLK10.66851526
84CSNK1G20.66291517
85CAMK2A0.65290213
86NME10.63499937
87ATR0.62439876
88PDK20.62350940
89MAPK150.58518279
90VRK10.57999552
91FLT30.57974792
92AURKB0.56966663
93EIF2AK30.56470865
94CLK10.54976157
95CDC70.54868519
96WNK30.54629911
97SRPK10.54588164
98CDK80.52693969
99NLK0.51612391
100BRAF0.51298643
101CDK190.51044513
102ADRBK10.50499231
103PRKCQ0.50454438
104EIF2AK10.49979336
105TTK0.47930649
106WNK10.47830064
107CSNK1E0.47549847
108PLK40.47214856
109WNK40.46533267
110PRKCG0.45719402
111CSNK2A20.44627547
112CHUK0.44293960
113CAMK10.44125407
114PIM20.44005607
115LYN0.43896453
116CAMK2B0.43891811
117CSNK2A10.41703365
118KSR10.41511155
119ATM0.41005380
120PRKACB0.39653021
121RPS6KA50.39504912
122PRKD20.39407171
123FES0.38805417
124PRKACA0.38361782
125MAP3K70.38160469
126SGK10.36211334
127ERBB40.36093616
128MST1R0.35674154
129PLK30.34295057
130TAOK20.34277577
131PRKG10.33964194
132CSNK1A10.33622023
133ACVR1B0.33027661
134PRKCH0.31252528
135AURKA0.31196352
136EPHA20.30917796
137ERBB20.30877679
138FER0.30485535
139MAP2K60.30270546
140CCNB10.29568355
141PIK3CA0.29048585
142TRPM70.28924426
143PNCK0.26457666
144NME20.26378988
145DAPK20.25947304
146MAP3K120.25893550
147PRKCD0.24494265
148BUB10.23978066
149CSNK1A1L0.23454784
150PRKCA0.22956258
151MAPK120.22639006

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.97979153
2Nicotine addiction_Homo sapiens_hsa050332.93002584
3Parkinsons disease_Homo sapiens_hsa050122.80514891
4Autoimmune thyroid disease_Homo sapiens_hsa053202.62602374
5Allograft rejection_Homo sapiens_hsa053302.60271293
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.55921618
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.50690675
8Protein export_Homo sapiens_hsa030602.48075712
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.40690472
10Graft-versus-host disease_Homo sapiens_hsa053322.35774714
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.35765671
12One carbon pool by folate_Homo sapiens_hsa006702.16413573
13Huntingtons disease_Homo sapiens_hsa050162.03643992
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02653314
15Phototransduction_Homo sapiens_hsa047442.02429487
16Butanoate metabolism_Homo sapiens_hsa006502.00153501
17Fanconi anemia pathway_Homo sapiens_hsa034601.86214845
18Rheumatoid arthritis_Homo sapiens_hsa053231.85842645
19Nitrogen metabolism_Homo sapiens_hsa009101.80735268
20Sphingolipid metabolism_Homo sapiens_hsa006001.79453277
21Vitamin B6 metabolism_Homo sapiens_hsa007501.72113374
22Morphine addiction_Homo sapiens_hsa050321.69405494
23Cardiac muscle contraction_Homo sapiens_hsa042601.68637033
24Asthma_Homo sapiens_hsa053101.66208914
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65941596
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.65203295
27Selenocompound metabolism_Homo sapiens_hsa004501.60670385
28Ether lipid metabolism_Homo sapiens_hsa005651.58677281
29Serotonergic synapse_Homo sapiens_hsa047261.57350504
30RNA degradation_Homo sapiens_hsa030181.55235016
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55191323
32Taste transduction_Homo sapiens_hsa047421.54387207
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51588348
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51416037
35Propanoate metabolism_Homo sapiens_hsa006401.50619873
36Mismatch repair_Homo sapiens_hsa034301.48317891
37Glutamatergic synapse_Homo sapiens_hsa047241.44412655
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43173265
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42236778
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41803975
41Type I diabetes mellitus_Homo sapiens_hsa049401.38254798
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.37783800
43Steroid biosynthesis_Homo sapiens_hsa001001.36364470
44RNA polymerase_Homo sapiens_hsa030201.33312688
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32529898
46Regulation of autophagy_Homo sapiens_hsa041401.27118761
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25594400
48Collecting duct acid secretion_Homo sapiens_hsa049661.24429197
49Arachidonic acid metabolism_Homo sapiens_hsa005901.24018416
50GABAergic synapse_Homo sapiens_hsa047271.23115954
51Axon guidance_Homo sapiens_hsa043601.20740101
52African trypanosomiasis_Homo sapiens_hsa051431.19143717
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17968702
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17811239
55Phagosome_Homo sapiens_hsa041451.16531325
56Homologous recombination_Homo sapiens_hsa034401.16452159
57RNA transport_Homo sapiens_hsa030131.09775835
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09511621
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08556837
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08208421
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06460806
62Peroxisome_Homo sapiens_hsa041461.05071292
63Spliceosome_Homo sapiens_hsa030401.03700898
64Tryptophan metabolism_Homo sapiens_hsa003801.03597439
65Basal transcription factors_Homo sapiens_hsa030221.02603707
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02016559
67Calcium signaling pathway_Homo sapiens_hsa040200.98943040
68Vitamin digestion and absorption_Homo sapiens_hsa049770.96627091
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95902293
70Folate biosynthesis_Homo sapiens_hsa007900.95598243
71Salivary secretion_Homo sapiens_hsa049700.90293378
72Mineral absorption_Homo sapiens_hsa049780.90143601
73Circadian entrainment_Homo sapiens_hsa047130.87985166
74Measles_Homo sapiens_hsa051620.87946896
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87491397
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.86444196
77Linoleic acid metabolism_Homo sapiens_hsa005910.85358582
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.85342092
79Metabolic pathways_Homo sapiens_hsa011000.83359963
80Caffeine metabolism_Homo sapiens_hsa002320.82794986
81Fatty acid elongation_Homo sapiens_hsa000620.81316582
82Base excision repair_Homo sapiens_hsa034100.79512037
83Staphylococcus aureus infection_Homo sapiens_hsa051500.77612456
84Long-term depression_Homo sapiens_hsa047300.76502716
85Basal cell carcinoma_Homo sapiens_hsa052170.74624299
86Pyruvate metabolism_Homo sapiens_hsa006200.73732180
87Primary immunodeficiency_Homo sapiens_hsa053400.73703171
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73666919
89Tuberculosis_Homo sapiens_hsa051520.73365990
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72419890
91DNA replication_Homo sapiens_hsa030300.72284761
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72263759
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71009439
94Malaria_Homo sapiens_hsa051440.70150178
95Olfactory transduction_Homo sapiens_hsa047400.67606500
96Purine metabolism_Homo sapiens_hsa002300.66871969
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.66769830
98Chemokine signaling pathway_Homo sapiens_hsa040620.66561470
99Ras signaling pathway_Homo sapiens_hsa040140.66141889
100Leishmaniasis_Homo sapiens_hsa051400.65782593
101Oxidative phosphorylation_Homo sapiens_hsa001900.65710684
102Nucleotide excision repair_Homo sapiens_hsa034200.65640872
103Chemical carcinogenesis_Homo sapiens_hsa052040.65125821
104Sulfur relay system_Homo sapiens_hsa041220.64224972
105Synaptic vesicle cycle_Homo sapiens_hsa047210.63981452
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63863600
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63545786
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63528327
109Circadian rhythm_Homo sapiens_hsa047100.63316675
110Ovarian steroidogenesis_Homo sapiens_hsa049130.62853155
111Hematopoietic cell lineage_Homo sapiens_hsa046400.61269264
112Hedgehog signaling pathway_Homo sapiens_hsa043400.59738476
113Sulfur metabolism_Homo sapiens_hsa009200.59594022
114Retinol metabolism_Homo sapiens_hsa008300.59573898
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.59064069
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58164915
117Wnt signaling pathway_Homo sapiens_hsa043100.57922222
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57337564
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56086722
120Melanoma_Homo sapiens_hsa052180.55663400
121Herpes simplex infection_Homo sapiens_hsa051680.53627261
122Influenza A_Homo sapiens_hsa051640.53200354
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52637631
124Amphetamine addiction_Homo sapiens_hsa050310.50279113
125beta-Alanine metabolism_Homo sapiens_hsa004100.50112003
126Proteasome_Homo sapiens_hsa030500.49796608
127ABC transporters_Homo sapiens_hsa020100.49562908
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48546192
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47698628
130Dorso-ventral axis formation_Homo sapiens_hsa043200.47037103
131Fat digestion and absorption_Homo sapiens_hsa049750.46747289
132Arginine and proline metabolism_Homo sapiens_hsa003300.44853746
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44159371
134Histidine metabolism_Homo sapiens_hsa003400.42336651
135Pyrimidine metabolism_Homo sapiens_hsa002400.41772559
136Fatty acid metabolism_Homo sapiens_hsa012120.41175103
137MAPK signaling pathway_Homo sapiens_hsa040100.40618800
138Oxytocin signaling pathway_Homo sapiens_hsa049210.40414837
139Tyrosine metabolism_Homo sapiens_hsa003500.40305110
140Insulin secretion_Homo sapiens_hsa049110.39845926
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39585991
142Cocaine addiction_Homo sapiens_hsa050300.38943416
143Cholinergic synapse_Homo sapiens_hsa047250.37808510
144Pertussis_Homo sapiens_hsa051330.37585657
145p53 signaling pathway_Homo sapiens_hsa041150.36454497
146Osteoclast differentiation_Homo sapiens_hsa043800.35884973
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35245768
148Alzheimers disease_Homo sapiens_hsa050100.33545245
149Non-homologous end-joining_Homo sapiens_hsa034500.33485750
150Renin secretion_Homo sapiens_hsa049240.31481073
151Glutathione metabolism_Homo sapiens_hsa004800.31246190
152Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31086324
153Fatty acid biosynthesis_Homo sapiens_hsa000610.29020352

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