DMBT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. This gene was originally isolated based on its deletion in a medulloblastoma cell line. This gene is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The encoded protein precursor is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)7.80271519
2intestinal absorption (GO:0050892)7.37060126
3UDP-N-acetylglucosamine metabolic process (GO:0006047)7.28146382
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.20247721
5maintenance of gastrointestinal epithelium (GO:0030277)7.16986794
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.90784963
7intestinal epithelial cell development (GO:0060576)6.90169398
8regulation of cellular extravasation (GO:0002691)6.67452793
9hemidesmosome assembly (GO:0031581)6.38438404
10positive regulation of respiratory burst (GO:0060267)6.29025016
11epithelial structure maintenance (GO:0010669)5.67593170
12NADH metabolic process (GO:0006734)5.53444070
13glomerular filtration (GO:0003094)5.48449877
14regulation of guanylate cyclase activity (GO:0031282)5.23314995
15cGMP-mediated signaling (GO:0019934)5.19674543
16transcytosis (GO:0045056)5.12357031
17renal filtration (GO:0097205)5.04305272
18flavonoid metabolic process (GO:0009812)4.97112534
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.89443933
20digestion (GO:0007586)4.86261629
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.83055169
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.83055169
23complement activation, classical pathway (GO:0006958)4.82379920
24actin filament depolymerization (GO:0030042)4.79513369
25O-glycan processing (GO:0016266)4.79187015
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.75414101
27* antibacterial humoral response (GO:0019731)4.75116678
28* antimicrobial humoral response (GO:0019730)4.66482339
29lipoprotein transport (GO:0042953)4.64761197
30regulation of systemic arterial blood pressure by hormone (GO:0001990)4.62004515
31regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.62004515
32endocrine process (GO:0050886)4.62004515
33regulation of respiratory burst (GO:0060263)4.60049518
34antigen processing and presentation of endogenous antigen (GO:0019883)4.49132444
35digestive system process (GO:0022600)4.44958599
36cellular ketone body metabolic process (GO:0046950)4.43310433
37fucose catabolic process (GO:0019317)4.34156043
38L-fucose metabolic process (GO:0042354)4.34156043
39L-fucose catabolic process (GO:0042355)4.34156043
40adhesion of symbiont to host cell (GO:0044650)4.33130539
41virion attachment to host cell (GO:0019062)4.33130539
42vitamin transmembrane transport (GO:0035461)4.32806175
43regulation of systemic arterial blood pressure (GO:0003073)4.24724288
44positive regulation of guanylate cyclase activity (GO:0031284)4.24703913
45urea cycle (GO:0000050)4.22221594
46hormone catabolic process (GO:0042447)4.18943363
47peptide catabolic process (GO:0043171)4.16116186
48pyrimidine-containing compound transmembrane transport (GO:0072531)4.15820188
49sulfur amino acid catabolic process (GO:0000098)4.11399763
50nucleotide-sugar biosynthetic process (GO:0009226)4.06173608
51regulation of hydrogen peroxide metabolic process (GO:0010310)4.04171006
52arginine metabolic process (GO:0006525)4.04034173
53sulfation (GO:0051923)4.03162831
54regulation of viral release from host cell (GO:1902186)4.02916713
55calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.99368617
56fructose metabolic process (GO:0006000)3.98340455
57regulation of vitamin metabolic process (GO:0030656)3.95348247
58epoxygenase P450 pathway (GO:0019373)3.94126888
59fat-soluble vitamin biosynthetic process (GO:0042362)3.93543865
60urea metabolic process (GO:0019627)3.93441575
61diacylglycerol metabolic process (GO:0046339)3.92826363
62hepatocyte apoptotic process (GO:0097284)3.92130285
63bile acid and bile salt transport (GO:0015721)3.88133092
64regulation of bile acid biosynthetic process (GO:0070857)3.86064837
65complement activation (GO:0006956)3.85954608
66positive regulation of glycoprotein biosynthetic process (GO:0010560)3.81082076
67ketone body metabolic process (GO:1902224)3.80854623
68regulation of RIG-I signaling pathway (GO:0039535)3.71460523
69peptide hormone processing (GO:0016486)3.70022923
70thyroid hormone metabolic process (GO:0042403)3.67901888
71adhesion of symbiont to host (GO:0044406)3.63803564
72nitrogen cycle metabolic process (GO:0071941)3.63652027
73arginine catabolic process (GO:0006527)3.56893064
74glycosphingolipid catabolic process (GO:0046479)3.55363758
75positive regulation of glycoprotein metabolic process (GO:1903020)3.53502419
76glycolipid catabolic process (GO:0019377)3.53299090
77nucleotide-sugar metabolic process (GO:0009225)3.52079110
78regulation of T cell tolerance induction (GO:0002664)3.50765139
79ventricular cardiac muscle cell action potential (GO:0086005)3.49702206
80renal system process involved in regulation of blood volume (GO:0001977)3.49667360
81glucose 6-phosphate metabolic process (GO:0051156)3.47807899
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.47599877
83oligosaccharide biosynthetic process (GO:0009312)3.42539551
84desmosome organization (GO:0002934)3.39996186
85protein retention in ER lumen (GO:0006621)3.37782084
86very-low-density lipoprotein particle assembly (GO:0034379)3.34787451
87uronic acid metabolic process (GO:0006063)3.33605322
88glucuronate metabolic process (GO:0019585)3.33605322
89midgut development (GO:0007494)3.33351144
90regulation of cGMP metabolic process (GO:0030823)3.30296402
91response to nitric oxide (GO:0071731)3.29842401
92eosinophil chemotaxis (GO:0048245)3.29443624
93GDP-mannose metabolic process (GO:0019673)3.27818147
94positive regulation of Cdc42 GTPase activity (GO:0043089)3.24802396
95production of molecular mediator involved in inflammatory response (GO:0002532)3.24396441
96receptor guanylyl cyclase signaling pathway (GO:0007168)3.22494961
97phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.22209171
98cellular response to nitric oxide (GO:0071732)3.21038287
99exocrine pancreas development (GO:0031017)3.19122378
100phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.16874170
101sulfate transmembrane transport (GO:1902358)3.16791076
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.15854148
103cell communication involved in cardiac conduction (GO:0086065)3.15273260
104sexual reproduction (GO:0019953)3.14268148
105positive regulation of pseudopodium assembly (GO:0031274)3.13479036
106ethanol oxidation (GO:0006069)3.13293687
107bicarbonate transport (GO:0015701)3.12311159
108cellular response to hepatocyte growth factor stimulus (GO:0035729)3.10602118
109response to hepatocyte growth factor (GO:0035728)3.10602118
110drug metabolic process (GO:0017144)3.08815575
111low-density lipoprotein particle remodeling (GO:0034374)3.06877573
112phosphatidylserine acyl-chain remodeling (GO:0036150)3.06695705
113lung secretory cell differentiation (GO:0061140)3.06482365
114nucleoside diphosphate biosynthetic process (GO:0009133)3.05309374
115keratinocyte proliferation (GO:0043616)3.04234985
116regulation of cholesterol homeostasis (GO:2000188)3.02277938
117cellular response to reactive nitrogen species (GO:1902170)3.01666086
118regulation of cGMP biosynthetic process (GO:0030826)3.01152439
119positive regulation of cGMP biosynthetic process (GO:0030828)3.00671200
120fucose metabolic process (GO:0006004)3.00659616
121regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.00585402
122lipid translocation (GO:0034204)2.97549565
123phospholipid translocation (GO:0045332)2.97549565
124vitamin A metabolic process (GO:0006776)2.95412498
125cell differentiation involved in embryonic placenta development (GO:0060706)2.94604330
126epithelial cell-cell adhesion (GO:0090136)2.94584909
127protein O-linked glycosylation (GO:0006493)2.94169809
128glutamine family amino acid biosynthetic process (GO:0009084)2.93788549
129striated muscle atrophy (GO:0014891)2.93020105
130tight junction assembly (GO:0070830)2.92970586
131eosinophil migration (GO:0072677)2.92390120
132cytidine deamination (GO:0009972)2.90798486
133cytidine metabolic process (GO:0046087)2.90798486
134cytidine catabolic process (GO:0006216)2.90798486
135lipoprotein metabolic process (GO:0042157)2.90042693
136protein activation cascade (GO:0072376)2.89882399
137positive regulation of tolerance induction (GO:0002645)2.89811422
138galactose catabolic process (GO:0019388)2.88492899
139innate immune response in mucosa (GO:0002227)2.88347134
140hydrogen peroxide catabolic process (GO:0042744)2.88163018
141cellular glucuronidation (GO:0052695)2.87510071
142homocysteine metabolic process (GO:0050667)2.85471803
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85329937
144drug catabolic process (GO:0042737)2.85043144
145positive regulation of antigen processing and presentation (GO:0002579)2.84560125
146neurotransmitter biosynthetic process (GO:0042136)2.83336314
147ceramide catabolic process (GO:0046514)2.82392353
148sulfur compound transport (GO:0072348)2.80967226
149diterpenoid biosynthetic process (GO:0016102)2.80862907
150plasma lipoprotein particle assembly (GO:0034377)2.80225134
151thyroid hormone generation (GO:0006590)2.79979168
152cardiac conduction (GO:0061337)2.79543453
153regulation of heart rate by cardiac conduction (GO:0086091)2.78655547
154auditory receptor cell differentiation (GO:0042491)2.78333533
155regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78221790
156hydrogen peroxide metabolic process (GO:0042743)2.74833078
157columnar/cuboidal epithelial cell development (GO:0002066)2.74706602
158phosphatidylcholine biosynthetic process (GO:0006656)2.74507241
159protein neddylation (GO:0045116)2.72684648
160thrombin receptor signaling pathway (GO:0070493)2.71957279
161phosphatidylserine metabolic process (GO:0006658)2.71128658
162angiotensin maturation (GO:0002003)2.70710548
163detection of bacterium (GO:0016045)2.66120088
164regulation of pseudopodium assembly (GO:0031272)2.65554793
165hexose catabolic process (GO:0019320)2.65033074
166N-glycan processing (GO:0006491)2.64996583
167fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.64616327
168regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.64022033
169mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63493661
170protein-lipid complex assembly (GO:0065005)2.62887128
171alkaloid metabolic process (GO:0009820)2.61100820
172positive regulation of cGMP metabolic process (GO:0030825)2.60728519
173regulation of extracellular matrix disassembly (GO:0010715)2.60578154
174phosphatidylinositol acyl-chain remodeling (GO:0036149)2.60299728
175sphingolipid catabolic process (GO:0030149)2.60268617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.69071810
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.39031912
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.99047231
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.49646378
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.39850207
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.27792405
7GATA4_25053715_ChIP-Seq_YYC3_Human3.19980078
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.04211847
9SOX2_20726797_ChIP-Seq_SW620_Human2.98757065
10GATA6_25053715_ChIP-Seq_YYC3_Human2.95059131
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.92178776
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.65665554
13STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43857008
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30115232
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24120692
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.15382158
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.11409635
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.11115186
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.10567410
20KLF5_25053715_ChIP-Seq_YYC3_Human2.08151413
21FOXO3_23340844_ChIP-Seq_DLD1_Human2.05705002
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.02151063
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.01188797
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.99746572
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.98768953
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93357142
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.83308587
28CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83271203
29SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81883171
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77057428
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76847055
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75114519
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.72305022
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.71787298
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68977723
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68975889
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.64044298
38RACK7_27058665_Chip-Seq_MCF-7_Human1.56835091
39* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54915175
40GATA1_22025678_ChIP-Seq_K562_Human1.52657271
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51542130
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.49721930
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48696943
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48649551
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45064097
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.44922356
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44295675
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42569498
49ATF3_27146783_Chip-Seq_COLON_Human1.40492350
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39096197
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.38583401
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38052159
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38052159
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37914231
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37245034
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36419478
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34238879
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.31890220
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29076045
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26377455
61CLOCK_20551151_ChIP-Seq_293T_Human1.22274506
62EGR1_19032775_ChIP-ChIP_M12_Human1.18998867
63TCF4_18268006_ChIP-ChIP_LS174T_Human1.17009650
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16459539
65FOXA1_25552417_ChIP-Seq_VCAP_Human1.16110361
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13743833
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13268737
68DROSHA_22980978_ChIP-Seq_HELA_Human1.12676135
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.12542271
70FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12357535
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11852581
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11259104
73ZNF263_19887448_ChIP-Seq_K562_Human1.10945343
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.10484926
75CREB1_26743006_Chip-Seq_LNCaP_Human1.08098751
76GATA2_19941826_ChIP-Seq_K562_Human1.08070065
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07232792
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06651347
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06454763
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06176198
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06117300
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05414397
83NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04339642
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03876706
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03849555
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01564351
87* GATA3_24758297_ChIP-Seq_MCF-7_Human1.00290915
88TET1_21451524_ChIP-Seq_MESCs_Mouse0.97150586
89CDX2_22108803_ChIP-Seq_LS180_Human0.97118809
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96554109
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.95447422
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94823973
93SA1_27219007_Chip-Seq_Bcells_Human0.94374549
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94366886
95HNF4A_19822575_ChIP-Seq_HepG2_Human0.94036734
96AR_21909140_ChIP-Seq_LNCAP_Human0.93828110
97ELK3_25401928_ChIP-Seq_HUVEC_Human0.93081691
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91906145
99BCL6_27268052_Chip-Seq_Bcells_Human0.91721296
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91469352
101GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90905542
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90552194
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90542582
104JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90143330
105BCOR_27268052_Chip-Seq_Bcells_Human0.89199634
106GATA1_19941826_ChIP-Seq_K562_Human0.88628593
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88049185
108LXR_22292898_ChIP-Seq_THP-1_Human0.87589881
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86481143
110EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86351302
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86284593
112CTCF_27219007_Chip-Seq_Bcells_Human0.85284260
113TP63_22573176_ChIP-Seq_HFKS_Human0.84249019
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83004761
115HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82803345
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82206535
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.82159312
118RXR_22108803_ChIP-Seq_LS180_Human0.80327859
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79422317
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79223356
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78476441
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77741938
123STAT1_20625510_ChIP-Seq_HELA_Human0.77422917
124NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77305793
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.77246014
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76155614
127* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75560594
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75256062
129CEBPB_22108803_ChIP-Seq_LS180_Human0.74658205
130VDR_24787735_ChIP-Seq_THP-1_Human0.74436621
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.73587526
132AHR_22903824_ChIP-Seq_MCF-7_Human0.73479877
133ELF5_23300383_ChIP-Seq_T47D_Human0.73054853
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72920437
135VDR_24763502_ChIP-Seq_THP-1_Human0.72612554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.04704060
2MP0001666_abnormal_nutrient_absorption5.19728805
3MP0004264_abnormal_extraembryonic_tissu4.98434931
4MP0000462_abnormal_digestive_system3.96672469
5MP0009379_abnormal_foot_pigmentation3.44845769
6MP0005360_urolithiasis3.41922744
7MP0005365_abnormal_bile_salt3.37462726
8MP0000537_abnormal_urethra_morphology3.24861073
9MP0005085_abnormal_gallbladder_physiolo3.22131966
10MP0003866_abnormal_defecation3.21805440
11MP0003183_abnormal_peptide_metabolism3.18526511
12MP0003283_abnormal_digestive_organ3.01557973
13MP0010352_gastrointestinal_tract_polyps2.76030192
14MP0001873_stomach_inflammation2.71393692
15MP0005381_digestive/alimentary_phenotyp2.59585709
16MP0001663_abnormal_digestive_system2.59169109
17MP0001664_abnormal_digestion2.50822827
18* MP0010155_abnormal_intestine_physiology2.47245980
19MP0000490_abnormal_crypts_of2.26814611
20MP0003300_gastrointestinal_ulcer2.15608738
21MP0000477_abnormal_intestine_morphology2.15011990
22MP0005409_darkened_coat_color2.13534453
23MP0001849_ear_inflammation2.03704003
24MP0003705_abnormal_hypodermis_morpholog2.00307112
25MP0005083_abnormal_biliary_tract1.98049368
26MP0002822_catalepsy1.94765766
27MP0003868_abnormal_feces_composition1.92260180
28MP0003252_abnormal_bile_duct1.90639238
29MP0003806_abnormal_nucleotide_metabolis1.89021611
30MP0008875_abnormal_xenobiotic_pharmacok1.86661423
31MP0003724_increased_susceptibility_to1.77412016
32MP0002139_abnormal_hepatobiliary_system1.75448783
33MP0000538_abnormal_urinary_bladder1.73478063
34MP0006054_spinal_hemorrhage1.69233830
35MP0002876_abnormal_thyroid_physiology1.68388522
36MP0002796_impaired_skin_barrier1.61591916
37MP0005377_hearing/vestibular/ear_phenot1.58988197
38MP0003878_abnormal_ear_physiology1.58988197
39MP0000678_abnormal_parathyroid_gland1.50525857
40MP0005167_abnormal_blood-brain_barrier1.49540205
41MP0010678_abnormal_skin_adnexa1.46816671
42MP0004043_abnormal_pH_regulation1.38508175
43MP0001790_abnormal_immune_system1.38395273
44MP0005387_immune_system_phenotype1.38395273
45MP0001835_abnormal_antigen_presentation1.37060794
46MP0001765_abnormal_ion_homeostasis1.36831516
47MP0000470_abnormal_stomach_morphology1.35525531
48MP0002060_abnormal_skin_morphology1.35463985
49MP0005084_abnormal_gallbladder_morpholo1.34177493
50MP0003436_decreased_susceptibility_to1.29574651
51MP0003453_abnormal_keratinocyte_physiol1.28595409
52MP0001764_abnormal_homeostasis1.25443230
53MP0009643_abnormal_urine_homeostasis1.22892008
54MP0005187_abnormal_penis_morphology1.21674606
55MP0004782_abnormal_surfactant_physiolog1.21617719
56MP0003303_peritoneal_inflammation1.21040968
57MP0002277_abnormal_respiratory_mucosa1.20741159
58MP0002234_abnormal_pharynx_morphology1.19878886
59MP0005025_abnormal_response_to1.19726434
60MP0005166_decreased_susceptibility_to1.19585893
61MP0000604_amyloidosis1.18721856
62MP0005220_abnormal_exocrine_pancreas1.15014240
63MP0003191_abnormal_cellular_cholesterol1.13259056
64MP0004947_skin_inflammation1.10288184
65MP0001756_abnormal_urination1.09422223
66MP0009780_abnormal_chondrocyte_physiolo1.05969701
67MP0000516_abnormal_urinary_system1.05268124
68MP0005367_renal/urinary_system_phenotyp1.05268124
69MP0001188_hyperpigmentation1.05048033
70MP0005451_abnormal_body_composition1.04465623
71MP0005310_abnormal_salivary_gland1.03185811
72MP0001216_abnormal_epidermal_layer1.01605593
73MP0009384_cardiac_valve_regurgitation1.01582773
74MP0003315_abnormal_perineum_morphology0.99411781
75MP0010329_abnormal_lipoprotein_level0.99272082
76MP0001533_abnormal_skeleton_physiology0.98610032
77MP0009785_altered_susceptibility_to0.97275479
78MP0005636_abnormal_mineral_homeostasis0.96864535
79MP0000467_abnormal_esophagus_morphology0.96066361
80MP0005671_abnormal_response_to0.93196884
81MP0005501_abnormal_skin_physiology0.91676661
82MP0008004_abnormal_stomach_pH0.91334327
83MP0003941_abnormal_skin_development0.90932752
84MP0005584_abnormal_enzyme/coenzyme_acti0.90862594
85MP0004019_abnormal_vitamin_homeostasis0.89603228
86MP0005448_abnormal_energy_balance0.88864665
87MP0002998_abnormal_bone_remodeling0.85854909
88MP0006082_CNS_inflammation0.85647383
89MP0003045_fibrosis0.85560505
90MP0003448_altered_tumor_morphology0.85297010
91MP0003879_abnormal_hair_cell0.84253136
92MP0005058_abnormal_lysosome_morphology0.82465125
93MP0003075_altered_response_to0.81329863
94MP0002006_tumorigenesis0.81036755
95MP0000681_abnormal_thyroid_gland0.80982544
96MP0004858_abnormal_nervous_system0.79479079
97MP0008469_abnormal_protein_level0.79358349
98MP0005275_abnormal_skin_tensile0.78694238
99MP0002148_abnormal_hypersensitivity_rea0.78443513
100MP0000249_abnormal_blood_vessel0.77622093
101MP0002971_abnormal_brown_adipose0.75394358
102MP0001800_abnormal_humoral_immune0.75351508
103MP0002909_abnormal_adrenal_gland0.74484614
104MP0002138_abnormal_hepatobiliary_system0.74267473
105MP0009840_abnormal_foam_cell0.74251933
106MP0010771_integument_phenotype0.73381973
107MP0002118_abnormal_lipid_homeostasis0.73204289
108MP0001881_abnormal_mammary_gland0.72501219
109MP0002098_abnormal_vibrissa_morphology0.69919584
110MP0004147_increased_porphyrin_level0.69694430
111MP0000230_abnormal_systemic_arterial0.69306584
112MP0000613_abnormal_salivary_gland0.68785831
113MP0008872_abnormal_physiological_respon0.68063221
114MP0009764_decreased_sensitivity_to0.67559464
115MP0005535_abnormal_body_temperature0.67392845
116MP0005332_abnormal_amino_acid0.67343646
117MP0005000_abnormal_immune_tolerance0.66741315
118MP0001958_emphysema0.66594462
119MP0008775_abnormal_heart_ventricle0.66426169
120MP0009333_abnormal_splenocyte_physiolog0.66063038
121MP0005248_abnormal_Harderian_gland0.65993259
122MP0004270_analgesia0.65248040
123MP0000609_abnormal_liver_physiology0.65125758
124MP0004185_abnormal_adipocyte_glucose0.62857041
125MP0009053_abnormal_anal_canal0.61884119
126MP0003566_abnormal_cell_adhesion0.61049972
127MP0002896_abnormal_bone_mineralization0.61021394
128MP0003693_abnormal_embryo_hatching0.60953821
129MP0001501_abnormal_sleep_pattern0.60074085
130MP0002136_abnormal_kidney_physiology0.58574339
131MP0005319_abnormal_enzyme/_coenzyme0.58521869
132MP0003329_amyloid_beta_deposits0.57472969
133MP0002166_altered_tumor_susceptibility0.57058609
134MP0000465_gastrointestinal_hemorrhage0.56596045
135MP0000579_abnormal_nail_morphology0.56217041
136MP0008873_increased_physiological_sensi0.55022470
137MP0005165_increased_susceptibility_to0.55012154
138* MP0001845_abnormal_inflammatory_respons0.54696402
139MP0000762_abnormal_tongue_morphology0.54609820
140MP0005023_abnormal_wound_healing0.50450211

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)6.94178353
2Right ventricular cardiomyopathy (HP:0011663)6.53970489
3Pustule (HP:0200039)6.47080347
4Systemic lupus erythematosus (HP:0002725)6.17995352
5Onycholysis (HP:0001806)5.92259490
6Abnormality of the 1st metacarpal (HP:0010009)5.33287258
7Milia (HP:0001056)5.08959548
8Atrophic scars (HP:0001075)4.72205410
9Fragile nails (HP:0001808)4.64526582
10Abnormal tarsal ossification (HP:0008369)4.47931733
11Flat acetabular roof (HP:0003180)4.17855137
12Plantar hyperkeratosis (HP:0007556)3.85716005
13Hypobetalipoproteinemia (HP:0003563)3.84936665
14Glomerulonephritis (HP:0000099)3.78447567
15Eczematoid dermatitis (HP:0000976)3.70716890
16Short phalanx of the thumb (HP:0009660)3.62981300
17Abnormality of the vitamin B12 metabolism (HP:0004341)3.60527937
18Abnormality of complement system (HP:0005339)3.60338637
19Complement deficiency (HP:0004431)3.54767129
20Short 1st metacarpal (HP:0010034)3.46624669
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.46624669
22Widely patent fontanelles and sutures (HP:0004492)3.44620424
23Conjugated hyperbilirubinemia (HP:0002908)3.42052064
24Hyperactive renin-angiotensin system (HP:0000841)3.40972611
25Abnormality of carpal bone ossification (HP:0006257)3.37610670
26Abdominal distention (HP:0003270)3.37160653
27Abnormality of vitamin B metabolism (HP:0004340)3.33817091
28Abnormal foot bone ossification (HP:0010675)3.30822809
29Alkalosis (HP:0001948)3.29049082
30Fat malabsorption (HP:0002630)3.26712929
31Alopecia of scalp (HP:0002293)3.26240869
32Pigmentary retinal degeneration (HP:0001146)3.24692742
33Goiter (HP:0000853)3.20768385
34Chronic diarrhea (HP:0002028)3.20526982
35Ureteral stenosis (HP:0000071)3.20256135
36Nephritis (HP:0000123)3.19859464
37Fragile skin (HP:0001030)3.16249503
38Abnormality of the distal phalanx of the thumb (HP:0009617)3.13276697
39Cheilitis (HP:0100825)3.11612777
40Metabolic alkalosis (HP:0200114)3.05009869
41Thin bony cortex (HP:0002753)3.02178647
42Abnormality of the 2nd finger (HP:0004100)3.01568498
43Palpitations (HP:0001962)3.00067327
44Hemorrhage of the eye (HP:0011885)2.97865204
45Dehydration (HP:0001944)2.97736024
46Ureteral obstruction (HP:0006000)2.97495882
47Mildly elevated creatine phosphokinase (HP:0008180)2.94064786
48Rectal prolapse (HP:0002035)2.93442300
49Micronodular cirrhosis (HP:0001413)2.90361702
50Abnormality of small intestinal villus morphology (HP:0011472)2.86600487
51Villous atrophy (HP:0011473)2.86600487
52Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.83461993
53Woolly hair (HP:0002224)2.82379484
54Intrahepatic cholestasis (HP:0001406)2.80152231
55Malnutrition (HP:0004395)2.79361095
56Progressive sensorineural hearing impairment (HP:0000408)2.77522456
57Wide cranial sutures (HP:0010537)2.73693880
58Decreased circulating renin level (HP:0003351)2.72265240
59Abnormality of vitamin metabolism (HP:0100508)2.70986914
60Ankyloglossia (HP:0010296)2.70835211
61Abnormality of the gastric mucosa (HP:0004295)2.68359563
62Abnormality of chloride homeostasis (HP:0011422)2.67668642
63Nausea (HP:0002018)2.66495094
64Cupped ribs (HP:0000887)2.66148420
65Hypoplasia of dental enamel (HP:0006297)2.62755819
66Abnormal biliary tract morphology (HP:0012440)2.62437251
67Interstitial pulmonary disease (HP:0006530)2.61980672
68Hyperparathyroidism (HP:0000843)2.58840471
69Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58411717
70Abnormality of urine glucose concentration (HP:0011016)2.58188576
71Glycosuria (HP:0003076)2.58188576
72Abnormal hand bone ossification (HP:0010660)2.54350278
73Hypotension (HP:0002615)2.54200281
74Nephrolithiasis (HP:0000787)2.51159507
75Ventricular fibrillation (HP:0001663)2.48641533
76Abnormal ossification of hand bones (HP:0005921)2.47105078
77Confusion (HP:0001289)2.46714894
78Proximal tubulopathy (HP:0000114)2.44206521
79Abnormality of the proximal phalanges of the hand (HP:0009834)2.43265247
80Syncope (HP:0001279)2.42582311
81Short hallux (HP:0010109)2.39794849
82Hypophosphatemia (HP:0002148)2.39618111
83Pili torti (HP:0003777)2.38771527
84Increased purine levels (HP:0004368)2.38381867
85Hyperuricemia (HP:0002149)2.38381867
86Xanthomatosis (HP:0000991)2.37113458
87Gastrointestinal dysmotility (HP:0002579)2.36931347
88Gingivitis (HP:0000230)2.35980803
89Abnormality of renin-angiotensin system (HP:0000847)2.34505710
90Facial shape deformation (HP:0011334)2.33754919
91Potter facies (HP:0002009)2.33754919
92Biliary tract neoplasm (HP:0100574)2.32287542
93Abnormality of the phalanges of the hallux (HP:0010057)2.31058701
94Flattened epiphyses (HP:0003071)2.30702237
95Hyperammonemia (HP:0001987)2.30506351
96Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30138130
97Abnormality of the nasal mucosa (HP:0000433)2.29854523
98Progressive hearing impairment (HP:0001730)2.26263793
99Growth hormone excess (HP:0000845)2.25619239
100Symphalangism affecting the phalanges of the hand (HP:0009773)2.24359534
101Abnormal glucose tolerance (HP:0001952)2.23289248
102Poikiloderma (HP:0001029)2.23163813
103Congenital sensorineural hearing impairment (HP:0008527)2.21959333
104Hyperphosphatemia (HP:0002905)2.18823659
105Cerebral palsy (HP:0100021)2.18263765
106Periodontitis (HP:0000704)2.17991133
107Aplasia/Hypoplasia of the hallux (HP:0008362)2.17468112
108Colitis (HP:0002583)2.17208350
109Vascular calcification (HP:0004934)2.16469132
110Hoarse voice (HP:0001609)2.13195548
111Hyperglycinuria (HP:0003108)2.12446391
112Short middle phalanx of finger (HP:0005819)2.11864633
113Posterior subcapsular cataract (HP:0007787)2.10786147
114Pancreatitis (HP:0001733)2.10241535
115Focal segmental glomerulosclerosis (HP:0000097)2.10153200
116Esophageal varix (HP:0002040)2.08944737
117Abnormal cartilage morphology (HP:0002763)2.07725074
118Curly hair (HP:0002212)2.07569424
119Abnormality of purine metabolism (HP:0004352)2.04054200
120Ventricular tachycardia (HP:0004756)2.00936212
121Abnormality of nucleobase metabolism (HP:0010932)2.00588023
122Emphysema (HP:0002097)2.00346842
123Cardiovascular calcification (HP:0011915)1.99637149
124Enlarged epiphyses (HP:0010580)1.98101085
125Nail dystrophy (HP:0008404)1.97277667
126Acanthocytosis (HP:0001927)1.96207580
127Gout (HP:0001997)1.96087517
128Segmental peripheral demyelination/remyelination (HP:0003481)1.94939122
129Steatorrhea (HP:0002570)1.93636994
130Abnormality of pyrimidine metabolism (HP:0004353)1.93025456
131Protuberant abdomen (HP:0001538)1.92777484
132Abnormality of the middle phalanges of the toes (HP:0010183)1.92549389
133Inflammation of the large intestine (HP:0002037)1.91602228
134Esophageal atresia (HP:0002032)1.89670451
135Gastrointestinal stroma tumor (HP:0100723)1.88858268
136Bone pain (HP:0002653)1.88740398
137Abnormality of glycine metabolism (HP:0010895)1.88684695
138Abnormality of serine family amino acid metabolism (HP:0010894)1.88684695
139Hypolipoproteinemia (HP:0010981)1.87914101
140Uterine neoplasm (HP:0010784)1.87795197
141Abnormality of oral frenula (HP:0000190)1.87162715
142Bundle branch block (HP:0011710)1.85766578
143Abnormality of proline metabolism (HP:0010907)1.85304166
144Hydroxyprolinuria (HP:0003080)1.85304166
145Microretrognathia (HP:0000308)1.85123706
146Abnormal blistering of the skin (HP:0008066)1.85104178
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85004876
148Chronic otitis media (HP:0000389)1.84057147
149Abnormal pancreas size (HP:0012094)1.84000958
150Palmoplantar hyperkeratosis (HP:0000972)1.81602574
151Glomerulosclerosis (HP:0000096)1.79922042
152Vasculitis (HP:0002633)1.79028125
153Abnormal hair laboratory examination (HP:0003328)1.77887909
154Premature loss of primary teeth (HP:0006323)1.76139823
155Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76114472
156Dicarboxylic aciduria (HP:0003215)1.76114472
157Hyperaldosteronism (HP:0000859)1.75206842
158Bone cyst (HP:0012062)1.74317694
159Acute encephalopathy (HP:0006846)1.74193821
160Spontaneous hematomas (HP:0007420)1.73621247
161Gastrointestinal inflammation (HP:0004386)1.73592500
162Skin rash (HP:0000988)1.72208453
163Autoimmune hemolytic anemia (HP:0001890)1.71817516
164Male infertility (HP:0003251)1.71554405
165Multiple lipomas (HP:0001012)1.71461326
166Ventricular arrhythmia (HP:0004308)1.71046248
167Osteolytic defects of the hand bones (HP:0009699)1.70178423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.08649806
2MST1R5.52239271
3LMTK25.25975197
4ACVR1B5.10996312
5PIK3CA4.32991857
6MST43.73305049
7MAP2K23.56554116
8EPHA23.07985167
9PRKG22.91575296
10EPHA32.80962799
11TESK12.50798666
12RIPK12.46081635
13NME12.18488081
14MAP3K22.18067477
15ERN12.15085090
16MET1.95893788
17PTK61.94463724
18TAOK31.75838295
19FGFR31.64501152
20PRPF4B1.48736563
21MAP4K11.44356474
22EPHB21.43957033
23MAP2K11.43601189
24CDC42BPA1.41952246
25KSR21.28645986
26NLK1.25522156
27MYLK1.22787931
28FER1.21313896
29GRK61.15607524
30EPHB11.13657161
31STK241.13276363
32DDR21.13191908
33ZAP701.10141383
34PKN21.08950611
35PRKCI1.08172468
36IRAK11.02785967
37LIMK11.01274713
38ERBB21.00508525
39PTK20.98601479
40CAMK2D0.98343829
41ERBB40.96952918
42TAOK10.96203431
43PAK40.94025677
44MAP3K70.92696140
45LATS10.90552963
46MATK0.83758831
47TGFBR20.81797135
48MAP3K100.80793364
49STK390.77772500
50MAP2K60.75438624
51BCKDK0.75335322
52KIT0.75257800
53JAK30.73697785
54DMPK0.72685357
55IKBKE0.72384265
56TNIK0.72000307
57MAP3K80.70775371
58NUAK10.67245323
59MAP3K110.66357646
60MAP3K10.64898792
61MAP3K140.64670527
62PRKAA20.63133110
63NEK10.62686235
64STK100.61615082
65LRRK20.59548619
66BMX0.56400214
67TYK20.55533921
68PAK30.54985003
69PDGFRA0.54772513
70RIPK40.54231555
71BMPR20.54066396
72TRIB30.53969794
73SMG10.52151374
74MAP3K90.50950425
75TTK0.50414386
76PDPK10.49080337
77CSK0.48219541
78CAMK2B0.48045913
79MAP3K30.46544861
80SRC0.45794053
81YES10.45107268
82CDK60.43227647
83PRKAA10.42561455
84CAMK2G0.40874843
85WNK40.40545526
86TESK20.40368749
87AURKB0.38876547
88PDK10.38252475
89PDGFRB0.37980027
90MAPK110.37329400
91MAP3K120.37135443
92KDR0.36535787
93PRKCZ0.35134800
94SCYL20.35108785
95INSRR0.34548175
96TBK10.34431093
97* PRKCA0.34206458
98MAPKAPK20.33696680
99ICK0.33675583
100CSF1R0.33109707
101BLK0.32823617
102ABL20.32387416
103RPS6KA20.31430900
104CAMK1D0.31343617
105ROCK10.31011268
106MAPK70.30872703
107OXSR10.30782387
108EEF2K0.30754415
109DAPK30.30123792
110FYN0.29536342
111LYN0.29007125
112MELK0.28910215
113PRKCD0.28703620
114IRAK40.27803569
115PDK20.27256893
116MAP3K60.27030463
117STK110.26935439
118HIPK20.26923549
119IGF1R0.26662242
120PAK20.26383332
121BTK0.26264745
122CASK0.26088888
123PRKG10.25210403
124LCK0.24609403
125PAK10.24588166
126CAMKK10.24455422
127FGFR40.24348705
128PRKACG0.24287681
129JAK20.24145474
130CSNK1A10.23585449
131RPS6KB20.22899662
132SIK10.22437777
133RET0.20877309
134KSR10.20342641
135ALK0.19502487
136GRK10.18988165
137DYRK1B0.18870964
138AKT30.17909717
139MAPKAPK50.16331687
140JAK10.16096543

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.64777781
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.01942261
3Fat digestion and absorption_Homo sapiens_hsa049753.74030650
4Mineral absorption_Homo sapiens_hsa049783.01483993
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.88501810
6Pancreatic secretion_Homo sapiens_hsa049722.87043004
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.40177200
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26335677
9Asthma_Homo sapiens_hsa053102.23564298
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.22724811
11Fructose and mannose metabolism_Homo sapiens_hsa000512.21608632
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.02861117
13Protein digestion and absorption_Homo sapiens_hsa049741.98005863
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96130340
15Caffeine metabolism_Homo sapiens_hsa002321.87005755
16Bile secretion_Homo sapiens_hsa049761.84079426
17Galactose metabolism_Homo sapiens_hsa000521.80677808
18Staphylococcus aureus infection_Homo sapiens_hsa051501.77720541
19Allograft rejection_Homo sapiens_hsa053301.70772498
20Starch and sucrose metabolism_Homo sapiens_hsa005001.67021209
21Histidine metabolism_Homo sapiens_hsa003401.63581852
22Autoimmune thyroid disease_Homo sapiens_hsa053201.61462211
23Graft-versus-host disease_Homo sapiens_hsa053321.55932027
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52532448
25Renin-angiotensin system_Homo sapiens_hsa046141.47299868
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46522169
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38111140
28Folate biosynthesis_Homo sapiens_hsa007901.37652604
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36692501
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27705882
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27026697
32Type I diabetes mellitus_Homo sapiens_hsa049401.26873419
33Glycerolipid metabolism_Homo sapiens_hsa005611.26708999
34Thyroid hormone synthesis_Homo sapiens_hsa049181.26423266
35Vitamin digestion and absorption_Homo sapiens_hsa049771.22826083
36Butanoate metabolism_Homo sapiens_hsa006501.22586461
37Tight junction_Homo sapiens_hsa045301.22474898
38Tryptophan metabolism_Homo sapiens_hsa003801.17724930
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16561296
40Nitrogen metabolism_Homo sapiens_hsa009101.15683462
41Leishmaniasis_Homo sapiens_hsa051401.05788901
42Antigen processing and presentation_Homo sapiens_hsa046121.05348934
43Arginine biosynthesis_Homo sapiens_hsa002201.02678633
44Oxidative phosphorylation_Homo sapiens_hsa001901.01698187
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00069972
46Alzheimers disease_Homo sapiens_hsa050100.99426842
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96013373
48Salmonella infection_Homo sapiens_hsa051320.94682108
49Chemical carcinogenesis_Homo sapiens_hsa052040.89918227
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89692918
51Glutathione metabolism_Homo sapiens_hsa004800.87161997
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86897748
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86286038
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86213372
55Linoleic acid metabolism_Homo sapiens_hsa005910.83717551
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80651714
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.80622415
58Viral myocarditis_Homo sapiens_hsa054160.80273009
59African trypanosomiasis_Homo sapiens_hsa051430.79683954
60Parkinsons disease_Homo sapiens_hsa050120.79055427
61Other glycan degradation_Homo sapiens_hsa005110.78449773
62Fatty acid degradation_Homo sapiens_hsa000710.76333470
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75797794
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75155908
65Pentose phosphate pathway_Homo sapiens_hsa000300.72702907
66Thyroid cancer_Homo sapiens_hsa052160.70957833
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.70383235
68Arginine and proline metabolism_Homo sapiens_hsa003300.70314591
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.68959593
70Adherens junction_Homo sapiens_hsa045200.65486217
71Gastric acid secretion_Homo sapiens_hsa049710.64333738
72Carbon metabolism_Homo sapiens_hsa012000.61672966
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61634493
74Selenocompound metabolism_Homo sapiens_hsa004500.61255191
75ABC transporters_Homo sapiens_hsa020100.58315417
76Renin secretion_Homo sapiens_hsa049240.54150796
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53472979
78PPAR signaling pathway_Homo sapiens_hsa033200.53070019
79Bladder cancer_Homo sapiens_hsa052190.53038830
80Toxoplasmosis_Homo sapiens_hsa051450.52330928
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52215599
82Phenylalanine metabolism_Homo sapiens_hsa003600.50042268
83Hepatitis C_Homo sapiens_hsa051600.48823984
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47309259
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.45799034
86Pertussis_Homo sapiens_hsa051330.44662352
87Amoebiasis_Homo sapiens_hsa051460.44509938
88Tuberculosis_Homo sapiens_hsa051520.42871007
89Steroid biosynthesis_Homo sapiens_hsa001000.41673173
90N-Glycan biosynthesis_Homo sapiens_hsa005100.41614163
91Complement and coagulation cascades_Homo sapiens_hsa046100.41601291
92Propanoate metabolism_Homo sapiens_hsa006400.41507757
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41235411
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40198879
95Ether lipid metabolism_Homo sapiens_hsa005650.40057251
96beta-Alanine metabolism_Homo sapiens_hsa004100.39562694
97* Salivary secretion_Homo sapiens_hsa049700.38592187
98Cardiac muscle contraction_Homo sapiens_hsa042600.36947148
99ECM-receptor interaction_Homo sapiens_hsa045120.36785477
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.35757826
101Vibrio cholerae infection_Homo sapiens_hsa051100.35682169
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35651104
103Peroxisome_Homo sapiens_hsa041460.34844181
104Hematopoietic cell lineage_Homo sapiens_hsa046400.34551178
105Fatty acid metabolism_Homo sapiens_hsa012120.34420290
106Metabolic pathways_Homo sapiens_hsa011000.33740779
107Rheumatoid arthritis_Homo sapiens_hsa053230.33737222
108Fatty acid biosynthesis_Homo sapiens_hsa000610.32783708
109Influenza A_Homo sapiens_hsa051640.32238669
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30544527
111Small cell lung cancer_Homo sapiens_hsa052220.29899359
112Sphingolipid metabolism_Homo sapiens_hsa006000.29827771
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.29555364
114Insulin secretion_Homo sapiens_hsa049110.29222944
115Chemokine signaling pathway_Homo sapiens_hsa040620.28941784
116Insulin resistance_Homo sapiens_hsa049310.28047404
117Huntingtons disease_Homo sapiens_hsa050160.27479638
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27163006
119Retinol metabolism_Homo sapiens_hsa008300.26357378
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.26294565
121Type II diabetes mellitus_Homo sapiens_hsa049300.26271647
122Arachidonic acid metabolism_Homo sapiens_hsa005900.26162948
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25214017
124Phagosome_Homo sapiens_hsa041450.24462420
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24376195
126Pyruvate metabolism_Homo sapiens_hsa006200.23363790
127Legionellosis_Homo sapiens_hsa051340.23203311
128TNF signaling pathway_Homo sapiens_hsa046680.20802056
129Tyrosine metabolism_Homo sapiens_hsa003500.19836027
130Systemic lupus erythematosus_Homo sapiens_hsa053220.19826604
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.19615052
132GnRH signaling pathway_Homo sapiens_hsa049120.15256777
133Herpes simplex infection_Homo sapiens_hsa051680.13630339
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.11062901
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10438990
136Prion diseases_Homo sapiens_hsa050200.09293178
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06616060

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