DLX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.49974110
2axon ensheathment in central nervous system (GO:0032291)5.28073834
3central nervous system myelination (GO:0022010)5.28073834
4positive regulation of mitochondrial fission (GO:0090141)4.51889071
5limb bud formation (GO:0060174)4.47434858
6nucleobase catabolic process (GO:0046113)4.39836260
7glycosphingolipid biosynthetic process (GO:0006688)4.37813814
8protein-cofactor linkage (GO:0018065)4.26904614
9presynaptic membrane assembly (GO:0097105)4.25262078
10response to pheromone (GO:0019236)4.25011105
11neural tube formation (GO:0001841)4.22278252
12behavioral response to nicotine (GO:0035095)4.19052880
13neuron cell-cell adhesion (GO:0007158)4.08216056
14negative regulation of oligodendrocyte differentiation (GO:0048715)4.07340051
15somite development (GO:0061053)4.05773769
16presynaptic membrane organization (GO:0097090)3.95783388
17synapse assembly (GO:0007416)3.77958213
18glial cell proliferation (GO:0014009)3.74311058
19long-chain fatty acid biosynthetic process (GO:0042759)3.72950555
20cerebral cortex radially oriented cell migration (GO:0021799)3.67502741
21sequestering of actin monomers (GO:0042989)3.63705373
22positive regulation of oligodendrocyte differentiation (GO:0048714)3.60926995
23L-amino acid import (GO:0043092)3.59672101
24C4-dicarboxylate transport (GO:0015740)3.55640490
25establishment of mitochondrion localization (GO:0051654)3.54074239
26keratinocyte development (GO:0003334)3.53649665
27hippocampus development (GO:0021766)3.53447122
28histone H2A acetylation (GO:0043968)3.44048743
29positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.43587534
30transmission of nerve impulse (GO:0019226)3.41170807
31retina layer formation (GO:0010842)3.40997429
32protein localization to cilium (GO:0061512)3.40913587
33import into cell (GO:0098657)3.39699650
34righting reflex (GO:0060013)3.39434086
35adaptation of signaling pathway (GO:0023058)3.38916171
36negative regulation of transcription regulatory region DNA binding (GO:2000678)3.37386355
37regulation of oligodendrocyte differentiation (GO:0048713)3.31073803
38negative regulation of neurotransmitter transport (GO:0051589)3.30587192
39cardiac ventricle formation (GO:0003211)3.29284782
40neuronal action potential propagation (GO:0019227)3.28505461
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.25552054
42calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.25167492
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.22005068
44regulation of timing of cell differentiation (GO:0048505)3.19229279
45neuron remodeling (GO:0016322)3.17714235
46metallo-sulfur cluster assembly (GO:0031163)3.16210562
47iron-sulfur cluster assembly (GO:0016226)3.16210562
48postsynaptic membrane organization (GO:0001941)3.14741290
49nonmotile primary cilium assembly (GO:0035058)3.14285396
50vocalization behavior (GO:0071625)3.13910039
51organ growth (GO:0035265)3.11332349
52negative regulation of telomere maintenance (GO:0032205)3.10492988
53neuron recognition (GO:0008038)3.08837754
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08496860
55cranial nerve morphogenesis (GO:0021602)3.07031158
56glutamate receptor signaling pathway (GO:0007215)3.06832887
57positive regulation of action potential (GO:0045760)3.05700288
58protein polyglutamylation (GO:0018095)3.04286543
59positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04108951
60water-soluble vitamin biosynthetic process (GO:0042364)3.03372567
61regulation of mitochondrial fission (GO:0090140)3.02190163
62regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01274299
63spinal cord development (GO:0021510)3.00129265
64cardiac chamber formation (GO:0003207)2.99136632
65negative regulation of protein localization to cell surface (GO:2000009)2.97528209
66negative regulation of neurotransmitter secretion (GO:0046929)2.96607644
67DNA deamination (GO:0045006)2.96406914
68DNA damage response, detection of DNA damage (GO:0042769)2.94544862
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93126241
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.93126241
71NADH dehydrogenase complex assembly (GO:0010257)2.93126241
72dendritic spine morphogenesis (GO:0060997)2.92563234
73piRNA metabolic process (GO:0034587)2.91687730
74cellular response to epinephrine stimulus (GO:0071872)2.91455163
75forebrain neuron differentiation (GO:0021879)2.90953378
76negative regulation of execution phase of apoptosis (GO:1900118)2.90162367
77negative regulation of Notch signaling pathway (GO:0045746)2.89568632
78intraciliary transport (GO:0042073)2.86453148
79response to epinephrine (GO:0071871)2.84425094
80negative regulation of mast cell activation (GO:0033004)2.83456328
81myelination (GO:0042552)2.80577234
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79170917
83anterograde synaptic vesicle transport (GO:0048490)2.78963745
84glycerophospholipid catabolic process (GO:0046475)2.78898989
85neurotransmitter biosynthetic process (GO:0042136)2.78613323
86positive regulation of potassium ion transmembrane transport (GO:1901381)2.77992824
87DNA double-strand break processing (GO:0000729)2.77482302
88synaptic vesicle maturation (GO:0016188)2.76914882
89amino acid import (GO:0043090)2.76802421
90positive regulation of synapse assembly (GO:0051965)2.76561601
91protein complex biogenesis (GO:0070271)2.76037027
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75627538
93regulation of inositol phosphate biosynthetic process (GO:0010919)2.75622884
94base-excision repair, AP site formation (GO:0006285)2.74688090
95embryonic epithelial tube formation (GO:0001838)2.73289728
96synaptic vesicle exocytosis (GO:0016079)2.73167398
97axon ensheathment (GO:0008366)2.72978222
98ensheathment of neurons (GO:0007272)2.72978222
99mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72843975
100mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72843975
101startle response (GO:0001964)2.72814145
102regulation of pigment cell differentiation (GO:0050932)2.71149726
103protein localization to synapse (GO:0035418)2.70254836
104fatty acid elongation (GO:0030497)2.69392846
105cranial nerve development (GO:0021545)2.69329068
106cornea development in camera-type eye (GO:0061303)2.68910171
107regulation of development, heterochronic (GO:0040034)2.68138845
108L-serine transport (GO:0015825)2.64831569
109eye photoreceptor cell differentiation (GO:0001754)2.64707195
110photoreceptor cell differentiation (GO:0046530)2.64707195
111auditory behavior (GO:0031223)2.62053377
112regulation of sarcomere organization (GO:0060297)2.61931571
113reflex (GO:0060004)2.61887535
114regulation of cilium movement (GO:0003352)2.60995831
115negative regulation of glial cell differentiation (GO:0045686)2.60956669
116lateral sprouting from an epithelium (GO:0060601)2.60060284
117neuron-neuron synaptic transmission (GO:0007270)2.59611924
118short-term memory (GO:0007614)2.59318623
119sympathetic nervous system development (GO:0048485)2.59007752
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58851247
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58547834
122regulation of action potential (GO:0098900)2.58397350
123positive regulation of protein kinase C signaling (GO:0090037)2.58030469
124regulation of feeding behavior (GO:0060259)2.56522696
125neurotransmitter secretion (GO:0007269)2.56154719
126dicarboxylic acid catabolic process (GO:0043649)2.55265513
127regulation of transcription involved in cell fate commitment (GO:0060850)2.55075609
128cerebral cortex cell migration (GO:0021795)2.54508266
129neuronal ion channel clustering (GO:0045161)2.53380593
130ubiquinone metabolic process (GO:0006743)2.53352980
131regulation of telomere maintenance (GO:0032204)2.53205988
132spinal cord motor neuron differentiation (GO:0021522)2.52776462
133cell proliferation in forebrain (GO:0021846)2.52487247
134epithelial tube formation (GO:0072175)2.52466076
135regulation of synapse assembly (GO:0051963)2.51372984
136synaptic transmission, glutamatergic (GO:0035249)2.51228337
137dopamine biosynthetic process (GO:0042416)2.50913194
138positive regulation of meiosis (GO:0045836)2.50554379
139negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.49784030
140synapse organization (GO:0050808)2.49720375
141polyol transport (GO:0015791)2.49580870
142indolalkylamine metabolic process (GO:0006586)2.48701304
143microtubule depolymerization (GO:0007019)2.48172111
144oligodendrocyte differentiation (GO:0048709)2.48034873
145mechanosensory behavior (GO:0007638)2.47738021
146mitochondrial respiratory chain complex assembly (GO:0033108)2.47361184
147protein deneddylation (GO:0000338)2.47208502
148axoneme assembly (GO:0035082)2.46657900
149cullin deneddylation (GO:0010388)2.46334476
150neuron fate commitment (GO:0048663)2.46209374
151histone H2B ubiquitination (GO:0033523)2.44324936
152axonal fasciculation (GO:0007413)2.44105517
153cilium movement (GO:0003341)2.43714077
154gamma-aminobutyric acid transport (GO:0015812)2.42311449
155regulation of dopamine metabolic process (GO:0042053)2.41246976
156regulation of catecholamine metabolic process (GO:0042069)2.41246976
157regulation of glutamate receptor signaling pathway (GO:1900449)2.40382936
158regulation of collateral sprouting (GO:0048670)2.40086965
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38740959
160G-protein coupled receptor internalization (GO:0002031)2.38513894
161calcium ion import (GO:0070509)2.38222012
162positive regulation of dendritic spine development (GO:0060999)2.36118084
163positive regulation of meiotic cell cycle (GO:0051446)2.35046242
164adult walking behavior (GO:0007628)2.34881159
165epithelial cilium movement (GO:0003351)2.32981165
166substrate-independent telencephalic tangential migration (GO:0021826)2.32691289
167substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.32691289
168central nervous system projection neuron axonogenesis (GO:0021952)2.32346913
169axonemal dynein complex assembly (GO:0070286)2.31670119
170response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.30851186
171adult feeding behavior (GO:0008343)2.30408129
172epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30213667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.20681262
2ZNF274_21170338_ChIP-Seq_K562_Hela4.17091425
3GBX2_23144817_ChIP-Seq_PC3_Human3.65989068
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23748257
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81638185
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60391612
7TAF15_26573619_Chip-Seq_HEK293_Human2.58406902
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.57715836
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.57573664
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54702656
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51620300
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44799455
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39274423
14* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38870393
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31170176
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31170176
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30033721
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27870590
19* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27712722
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.25005189
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18692298
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09132226
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06718986
24VDR_22108803_ChIP-Seq_LS180_Human1.99344538
25EWS_26573619_Chip-Seq_HEK293_Human1.95037602
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.92732271
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89388638
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88009055
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87855895
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.85909814
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85472250
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84263317
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84139151
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83759952
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82321626
36AR_21572438_ChIP-Seq_LNCaP_Human1.80556569
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80520148
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.80294942
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79580990
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79272119
41P300_19829295_ChIP-Seq_ESCs_Human1.78356231
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77896976
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77117418
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76821506
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.75832671
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72886249
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.72767017
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71488114
49* RNF2_27304074_Chip-Seq_NSC_Mouse1.71225691
50CBP_20019798_ChIP-Seq_JUKART_Human1.70135600
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70135600
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69856009
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.64662071
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.63716817
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62154175
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61340783
57IRF1_19129219_ChIP-ChIP_H3396_Human1.59983123
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59819851
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.59272759
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.58575847
61IGF1R_20145208_ChIP-Seq_DFB_Human1.57152511
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.56729511
63FUS_26573619_Chip-Seq_HEK293_Human1.56170207
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54883070
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.53611191
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51308585
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47576312
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.47517302
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.47427758
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.44351041
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41071730
72* ER_23166858_ChIP-Seq_MCF-7_Human1.40746886
73REST_21632747_ChIP-Seq_MESCs_Mouse1.38774282
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.38454276
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.37885605
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37802403
77DROSHA_22980978_ChIP-Seq_HELA_Human1.36493809
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35730050
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35190887
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35140477
81P53_22387025_ChIP-Seq_ESCs_Mouse1.35095329
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.34701964
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.34507320
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33815304
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33486047
86* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32694635
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31293367
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29296083
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28995570
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27758298
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27554284
92P300_18555785_Chip-Seq_ESCs_Mouse1.27299773
93MYC_18940864_ChIP-ChIP_HL60_Human1.27296870
94TP53_18474530_ChIP-ChIP_U2OS_Human1.27038806
95TP53_22573176_ChIP-Seq_HFKS_Human1.26608664
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.26409744
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.21982421
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21045783
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20685086
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19294017
101ELK1_19687146_ChIP-ChIP_HELA_Human1.19185500
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.18677049
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17831277
104STAT3_23295773_ChIP-Seq_U87_Human1.17409250
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.17250181
106RUNX2_22187159_ChIP-Seq_PCA_Human1.16821010
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.16746756
108TP53_16413492_ChIP-PET_HCT116_Human1.16206254
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14386348
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13371057
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13242483
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12530666
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12530666
114TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12223902
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11703823
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.11419646
117TCF4_23295773_ChIP-Seq_U87_Human1.10973454
118AR_25329375_ChIP-Seq_VCAP_Human1.10816910
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09499500
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09279346
121* NCOR_22424771_ChIP-Seq_293T_Human1.09106062
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09064900
123VDR_23849224_ChIP-Seq_CD4+_Human1.08943241
124KDM2B_26808549_Chip-Seq_REH_Human1.08709566
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.08534288
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.07670369
127WT1_19549856_ChIP-ChIP_CCG9911_Human1.06769207
128* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06458846
129PU1_27457419_Chip-Seq_LIVER_Mouse1.06427901
130RING1B_27294783_Chip-Seq_ESCs_Mouse1.06329202
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.05982615
132ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05049886
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03291598
134CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02325781
135YY1_21170310_ChIP-Seq_MESCs_Mouse1.01462872
136JUN_21703547_ChIP-Seq_K562_Human1.00360256
137BCAT_22108803_ChIP-Seq_LS180_Human0.99411263
138TCF4_22108803_ChIP-Seq_LS180_Human0.99013342
139SOX2_19829295_ChIP-Seq_ESCs_Human0.98609760
140NANOG_19829295_ChIP-Seq_ESCs_Human0.98609760
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98454885
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.97951165
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96915500
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95389384
145GATA3_21878914_ChIP-Seq_MCF-7_Human0.95128798
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94889874
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.94889874
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94415464
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.92143215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.88590870
2MP0003136_yellow_coat_color3.54897456
3MP0008789_abnormal_olfactory_epithelium3.25162806
4MP0005409_darkened_coat_color3.24935679
5MP0001188_hyperpigmentation3.11521576
6MP0005499_abnormal_olfactory_system2.89476222
7MP0006292_abnormal_olfactory_placode2.83851533
8MP0000566_synostosis2.80664898
9MP0001486_abnormal_startle_reflex2.78381922
10MP0004742_abnormal_vestibular_system2.67181117
11MP0003122_maternal_imprinting2.38579344
12MP0009046_muscle_twitch2.37252362
13MP0005423_abnormal_somatic_nervous2.36541256
14MP0009745_abnormal_behavioral_response2.25711544
15MP0008877_abnormal_DNA_methylation2.13623143
16MP0004381_abnormal_hair_follicle2.10710501
17MP0003635_abnormal_synaptic_transmissio2.08005547
18MP0002272_abnormal_nervous_system2.07756848
19MP0002837_dystrophic_cardiac_calcinosis2.02887753
20MP0004859_abnormal_synaptic_plasticity2.01148176
21MP0002064_seizures1.95972637
22MP0005171_absent_coat_pigmentation1.95442125
23MP0002234_abnormal_pharynx_morphology1.89102717
24MP0004142_abnormal_muscle_tone1.88972974
25MP0000778_abnormal_nervous_system1.87171054
26MP0002572_abnormal_emotion/affect_behav1.84863473
27MP0003121_genomic_imprinting1.80063687
28MP0004270_analgesia1.80043475
29MP0001968_abnormal_touch/_nociception1.78302095
30MP0005645_abnormal_hypothalamus_physiol1.78161895
31MP0002735_abnormal_chemical_nociception1.75837147
32MP0006276_abnormal_autonomic_nervous1.75466236
33MP0000920_abnormal_myelination1.74077382
34MP0001440_abnormal_grooming_behavior1.74027281
35MP0001905_abnormal_dopamine_level1.73049009
36MP0001529_abnormal_vocalization1.71574413
37MP0001485_abnormal_pinna_reflex1.70679928
38MP0001501_abnormal_sleep_pattern1.66166088
39MP0002067_abnormal_sensory_capabilities1.64156344
40MP0005646_abnormal_pituitary_gland1.61882430
41MP0002063_abnormal_learning/memory/cond1.60791161
42MP0002277_abnormal_respiratory_mucosa1.59839862
43MP0002734_abnormal_mechanical_nocicepti1.59058989
44* MP0000026_abnormal_inner_ear1.56569953
45MP0001963_abnormal_hearing_physiology1.52774214
46MP0005551_abnormal_eye_electrophysiolog1.50292590
47MP0009250_abnormal_appendicular_skeleto1.48419501
48MP0005379_endocrine/exocrine_gland_phen1.47677905
49MP0002557_abnormal_social/conspecific_i1.46772155
50MP0003011_delayed_dark_adaptation1.44855442
51MP0003119_abnormal_digestive_system1.39131986
52MP0000631_abnormal_neuroendocrine_gland1.39102221
53MP0002184_abnormal_innervation1.38238485
54MP0001270_distended_abdomen1.36831972
55MP0002736_abnormal_nociception_after1.36131302
56MP0003646_muscle_fatigue1.35759947
57MP0003787_abnormal_imprinting1.34658719
58* MP0003938_abnormal_ear_development1.33681958
59MP0001970_abnormal_pain_threshold1.28552430
60MP0001986_abnormal_taste_sensitivity1.26546572
61MP0006072_abnormal_retinal_apoptosis1.25861275
62MP0004145_abnormal_muscle_electrophysio1.24861652
63MP0002752_abnormal_somatic_nervous1.24553206
64MP0008995_early_reproductive_senescence1.24526375
65MP0008260_abnormal_autophagy1.23967604
66MP0008058_abnormal_DNA_repair1.21921463
67MP0004811_abnormal_neuron_physiology1.21230059
68MP0004885_abnormal_endolymph1.20984231
69MP0002882_abnormal_neuron_morphology1.14145091
70MP0009379_abnormal_foot_pigmentation1.13961810
71MP0003221_abnormal_cardiomyocyte_apopto1.12959479
72MP0001661_extended_life_span1.12668213
73MP0002733_abnormal_thermal_nociception1.12134594
74MP0000383_abnormal_hair_follicle1.11229182
75MP0001346_abnormal_lacrimal_gland1.10460385
76MP0001984_abnormal_olfaction1.10058052
77MP0002822_catalepsy1.09711302
78MP0000516_abnormal_urinary_system1.09442360
79MP0005367_renal/urinary_system_phenotyp1.09442360
80MP0001764_abnormal_homeostasis1.08793953
81MP0003567_abnormal_fetal_cardiomyocyte1.08372921
82* MP0003755_abnormal_palate_morphology1.07114052
83* MP0000049_abnormal_middle_ear1.06211001
84MP0003690_abnormal_glial_cell1.05806267
85MP0002909_abnormal_adrenal_gland1.05724775
86MP0010386_abnormal_urinary_bladder1.05614956
87MP0003950_abnormal_plasma_membrane1.05038363
88MP0001664_abnormal_digestion1.03203178
89MP0003195_calcinosis1.01866604
90MP0003315_abnormal_perineum_morphology1.00760284
91MP0000462_abnormal_digestive_system0.99614562
92MP0000015_abnormal_ear_pigmentation0.99303203
93MP0002638_abnormal_pupillary_reflex0.98561355
94MP0000955_abnormal_spinal_cord0.96720226
95MP0002876_abnormal_thyroid_physiology0.95542564
96MP0009697_abnormal_copulation0.95536498
97* MP0002102_abnormal_ear_morphology0.95487066
98MP0002066_abnormal_motor_capabilities/c0.94990030
99MP0005253_abnormal_eye_physiology0.94650534
100MP0002160_abnormal_reproductive_system0.92685454
101MP0003385_abnormal_body_wall0.92624352
102MP0002229_neurodegeneration0.91464371
103MP0001502_abnormal_circadian_rhythm0.91302270
104MP0000762_abnormal_tongue_morphology0.91168292
105MP0004924_abnormal_behavior0.90950977
106MP0005386_behavior/neurological_phenoty0.90950977
107MP0005451_abnormal_body_composition0.90805869
108MP0005084_abnormal_gallbladder_morpholo0.90593300
109MP0002653_abnormal_ependyma_morphology0.88469679
110* MP0002249_abnormal_larynx_morphology0.88039785
111MP0008872_abnormal_physiological_respon0.87779989
112MP0008569_lethality_at_weaning0.87741582
113* MP0002233_abnormal_nose_morphology0.86783139
114MP0002282_abnormal_trachea_morphology0.85122244
115MP0002163_abnormal_gland_morphology0.83732574
116* MP0003937_abnormal_limbs/digits/tail_de0.83605326
117MP0005389_reproductive_system_phenotype0.83485100
118MP0000372_irregular_coat_pigmentation0.83256556
119MP0004133_heterotaxia0.82265425
120MP0003878_abnormal_ear_physiology0.82211166
121MP0005377_hearing/vestibular/ear_phenot0.82211166
122MP0005195_abnormal_posterior_eye0.81435314
123MP0003698_abnormal_male_reproductive0.81146148
124MP0003634_abnormal_glial_cell0.80930939
125MP0003137_abnormal_impulse_conducting0.80371891
126MP0004134_abnormal_chest_morphology0.79746088
127MP0002938_white_spotting0.78958199
128* MP0002177_abnormal_outer_ear0.77243673
129MP0001919_abnormal_reproductive_system0.76750529
130MP0005410_abnormal_fertilization0.74947967
131* MP0003861_abnormal_nervous_system0.74124330
132* MP0002152_abnormal_brain_morphology0.73635312
133MP0002210_abnormal_sex_determination0.72691718
134MP0002751_abnormal_autonomic_nervous0.72171663
135MP0000647_abnormal_sebaceous_gland0.71349597
136MP0005394_taste/olfaction_phenotype0.68484353

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.83360934
2Absent/shortened dynein arms (HP:0200106)4.83360934
3Abnormal ciliary motility (HP:0012262)4.21284269
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.09344460
5Septo-optic dysplasia (HP:0100842)3.92213366
6Focal motor seizures (HP:0011153)3.83567245
7Pendular nystagmus (HP:0012043)3.71891073
8Progressive inability to walk (HP:0002505)3.63444788
9Abnormality of the labia minora (HP:0012880)3.61887608
10Abnormal respiratory motile cilium physiology (HP:0012261)3.59181479
11Aplasia cutis congenita (HP:0001057)3.59180078
12Abnormal respiratory motile cilium morphology (HP:0005938)3.56690829
13Abnormal respiratory epithelium morphology (HP:0012253)3.56690829
14Split foot (HP:0001839)3.49481576
15Drooling (HP:0002307)3.44184036
16Thyroid-stimulating hormone excess (HP:0002925)3.41894223
17Parakeratosis (HP:0001036)3.34857624
18Lissencephaly (HP:0001339)3.19032853
19Excessive salivation (HP:0003781)3.17214935
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.09492095
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09492095
22Inability to walk (HP:0002540)3.05314795
23White forelock (HP:0002211)3.05114830
24Pachygyria (HP:0001302)3.03458761
25Polyphagia (HP:0002591)3.01514326
26True hermaphroditism (HP:0010459)2.99462037
27Molar tooth sign on MRI (HP:0002419)2.97750636
28Abnormality of midbrain morphology (HP:0002418)2.97750636
29Absent septum pellucidum (HP:0001331)2.95216049
30Intestinal atresia (HP:0011100)2.94412074
31Pancreatic cysts (HP:0001737)2.94165365
32Febrile seizures (HP:0002373)2.94132717
33Patchy hypopigmentation of hair (HP:0011365)2.85590075
34Duplicated collecting system (HP:0000081)2.68412407
35Pancreatic fibrosis (HP:0100732)2.67502492
36Morphological abnormality of the middle ear (HP:0008609)2.67492528
37Decreased central vision (HP:0007663)2.60263051
38Nasolacrimal duct obstruction (HP:0000579)2.60120584
39Abnormality of the septum pellucidum (HP:0007375)2.59702697
40Abolished electroretinogram (ERG) (HP:0000550)2.53909896
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.53770050
42Short 1st metacarpal (HP:0010034)2.53770050
43Nephrogenic diabetes insipidus (HP:0009806)2.53049580
44Tubulointerstitial nephritis (HP:0001970)2.52969936
45Congenital primary aphakia (HP:0007707)2.50852408
46Type II lissencephaly (HP:0007260)2.50472098
47Upper limb muscle weakness (HP:0003484)2.48940802
48Overfolded helix (HP:0000396)2.48060597
49Optic nerve hypoplasia (HP:0000609)2.46121516
50Failure to thrive in infancy (HP:0001531)2.44534587
51Abnormality of the renal collecting system (HP:0004742)2.43790589
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39398655
53Conical tooth (HP:0000698)2.33076394
54Aplasia involving bones of the extremities (HP:0009825)2.32069441
55Aplasia involving bones of the upper limbs (HP:0009823)2.32069441
56Aplasia of the phalanges of the hand (HP:0009802)2.32069441
57Hyperventilation (HP:0002883)2.31286524
58Abnormality of incisor morphology (HP:0011063)2.31218554
59Methylmalonic acidemia (HP:0002912)2.30930704
60Agitation (HP:0000713)2.29956008
61Atelectasis (HP:0100750)2.29658463
62Congenital stationary night blindness (HP:0007642)2.26422787
63Cortical dysplasia (HP:0002539)2.25568409
64Abnormality of the lacrimal duct (HP:0011481)2.23273106
65Congenital sensorineural hearing impairment (HP:0008527)2.23065637
66Duplication of thumb phalanx (HP:0009942)2.22666392
67Anomalous pulmonary venous return (HP:0010772)2.22661827
68Abnormality of the axillary hair (HP:0100134)2.22631405
69Abnormality of secondary sexual hair (HP:0009888)2.22631405
70Aplasia/Hypoplasia of the patella (HP:0006498)2.22567846
71Abnormality of the 1st metacarpal (HP:0010009)2.22301026
72Chronic hepatic failure (HP:0100626)2.19467837
73Abnormality of the nasolacrimal system (HP:0000614)2.16425646
74Patellar aplasia (HP:0006443)2.14770999
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14764849
76Acute necrotizing encephalopathy (HP:0006965)2.14746610
77Spastic tetraplegia (HP:0002510)2.12499402
78Focal seizures (HP:0007359)2.12428251
79Abnormality of the corticospinal tract (HP:0002492)2.12224998
80Abnormality of the nasal septum (HP:0000419)2.11709566
81Atonic seizures (HP:0010819)2.11360066
82Abnormally folded helix (HP:0008544)2.09881877
83Neurofibrillary tangles (HP:0002185)2.09220812
84Cupped ear (HP:0000378)2.09090526
85Vaginal atresia (HP:0000148)2.08209211
86Metabolic alkalosis (HP:0200114)2.07517995
87Genital tract atresia (HP:0001827)2.07340013
88Abnormality of the pulmonary veins (HP:0011718)2.06641523
89Epileptic encephalopathy (HP:0200134)2.06223050
90Chromsome breakage (HP:0040012)2.05991238
91Broad-based gait (HP:0002136)2.04978807
92Rhinitis (HP:0012384)2.04935658
93Specific learning disability (HP:0001328)2.03277450
94Humeroradial synostosis (HP:0003041)2.03194367
95Synostosis involving the elbow (HP:0003938)2.03194367
96Dyskinesia (HP:0100660)2.02001773
97Gaze-evoked nystagmus (HP:0000640)2.00408261
98Abnormality of the renal cortex (HP:0011035)1.99896656
99Median cleft lip (HP:0000161)1.99003741
100Retinal dysplasia (HP:0007973)1.98389022
101Sensory axonal neuropathy (HP:0003390)1.98098374
102Hyperglycinemia (HP:0002154)1.97742620
103Mixed hearing impairment (HP:0000410)1.97309065
104Abnormal mitochondria in muscle tissue (HP:0008316)1.97007405
105Colon cancer (HP:0003003)1.95672511
106Progressive cerebellar ataxia (HP:0002073)1.95242996
107Chin dimple (HP:0010751)1.94398306
108Epidermoid cyst (HP:0200040)1.94294386
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94217834
110Amyotrophic lateral sclerosis (HP:0007354)1.93440677
111Abnormality of the renal medulla (HP:0100957)1.92488898
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.92146706
113Osteomalacia (HP:0002749)1.92109150
114Hypophosphatemic rickets (HP:0004912)1.90997156
115Alacrima (HP:0000522)1.90387639
116Progressive macrocephaly (HP:0004481)1.89622993
117Broad alveolar ridges (HP:0000187)1.89104492
118Hepatoblastoma (HP:0002884)1.88882913
119Sclerocornea (HP:0000647)1.88498252
120Short tibia (HP:0005736)1.88493208
121Popliteal pterygium (HP:0009756)1.88368098
122Hemiparesis (HP:0001269)1.86251024
123Urinary urgency (HP:0000012)1.85607932
124Short foot (HP:0001773)1.85476812
125Genetic anticipation (HP:0003743)1.85343282
126Renal cortical cysts (HP:0000803)1.84048833
127Methylmalonic aciduria (HP:0012120)1.83947383
128Hepatocellular necrosis (HP:0001404)1.83636401
1293-Methylglutaconic aciduria (HP:0003535)1.83554887
130Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83544518
131Hypoplasia of the brainstem (HP:0002365)1.83544518
132Postaxial hand polydactyly (HP:0001162)1.82227683
133Partial duplication of thumb phalanx (HP:0009944)1.81782650
134Gastroesophageal reflux (HP:0002020)1.81571093
135Neonatal respiratory distress (HP:0002643)1.81561605
136Limb dystonia (HP:0002451)1.81175845
137Abnormality of the columella (HP:0009929)1.80698013
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80625304
139Absent speech (HP:0001344)1.80452370
140Medial flaring of the eyebrow (HP:0010747)1.80204981
141Fibular aplasia (HP:0002990)1.80202383
142Polymicrogyria (HP:0002126)1.80179825
143Thickened helices (HP:0000391)1.79778071
144Abnormality of alanine metabolism (HP:0010916)1.79508196
145Hyperalaninemia (HP:0003348)1.79508196
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79508196
147Concave nail (HP:0001598)1.79453973
148Postaxial foot polydactyly (HP:0001830)1.79253291
149Intellectual disability, severe (HP:0010864)1.78937317
150Scrotal hypoplasia (HP:0000046)1.78888698
151Anophthalmia (HP:0000528)1.78628206
152Partial agenesis of the corpus callosum (HP:0001338)1.78267408
153Narrow forehead (HP:0000341)1.76839642
154Decreased lacrimation (HP:0000633)1.76618309
155Mitochondrial inheritance (HP:0001427)1.76162438
156Small hand (HP:0200055)1.75223580
157Renal agenesis (HP:0000104)1.74285402
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.73531185
159Abnormal drinking behavior (HP:0030082)1.73500034
160Polydipsia (HP:0001959)1.73500034
161Onion bulb formation (HP:0003383)1.73208968
162Nephronophthisis (HP:0000090)1.73162887
163Fibular hypoplasia (HP:0003038)1.72988666
164Acute encephalopathy (HP:0006846)1.72711772
165Increased CSF lactate (HP:0002490)1.72383654
166Prostate neoplasm (HP:0100787)1.72245331
167Generalized tonic-clonic seizures (HP:0002069)1.71474369
168Cystic liver disease (HP:0006706)1.71350484
169Peripheral hypomyelination (HP:0007182)1.71255415
170Mutism (HP:0002300)1.71211912
171Hepatic necrosis (HP:0002605)1.70285769
172Gonadotropin excess (HP:0000837)1.68981920
173Hypomagnesemia (HP:0002917)1.68221119
174Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68182903
175Aplasia/hypoplasia of the uterus (HP:0008684)1.68033901
176Aplasia of the musculature (HP:0100854)1.67977308
177Intellectual disability, progressive (HP:0006887)1.67572445
178Aplasia/Hypoplasia of the lens (HP:0008063)1.66789185
179Abnormal eating behavior (HP:0100738)1.66760815
180Widely spaced teeth (HP:0000687)1.65102976
181Esotropia (HP:0000565)1.62375806
182Gait imbalance (HP:0002141)1.61545352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.39188157
2MAP4K23.96140728
3TNIK3.93925952
4BLK3.83905995
5TRIM283.39087410
6MKNK22.69709764
7STK392.56482795
8FRK2.55653490
9NTRK32.43603781
10INSRR2.30092391
11EPHA42.12025864
12OXSR12.06567530
13STK161.98985134
14PINK11.90904503
15PNCK1.88836050
16PKN11.82460732
17SRPK11.74480044
18GRK11.69926744
19ADRBK21.67586247
20EPHA31.65364789
21NEK61.59810051
22STK38L1.55519245
23MINK11.55161087
24MKNK11.54604115
25MAP2K71.52719352
26MAPK131.46389126
27FGR1.43588787
28GRK71.41971604
29BMPR1B1.40341560
30MAP2K41.38181238
31MUSK1.36949178
32FES1.36150156
33MAP3K131.32089931
34TLK11.29371898
35RPS6KA41.29123153
36SIK21.25510554
37MARK11.24317153
38BCR1.23532146
39PRPF4B1.13561571
40NTRK21.12019045
41PBK1.10095464
42MAPK151.09487465
43VRK11.09037344
44MAP3K41.07745142
45ERBB31.06212505
46YES11.05219488
47CAMK1G1.04975400
48EPHB21.01975849
49CDK30.99981175
50WNK40.99517932
51WNK10.98787769
52EIF2AK20.98783043
53PRKCE0.98671875
54BMPR20.98203498
55TNK20.95872127
56RIPK40.95689572
57CAMK2A0.95588010
58CAMK2B0.94081959
59MAPKAPK50.93431278
60CDK190.92180773
61BCKDK0.91446862
62CLK10.90055245
63DAPK20.89451599
64IRAK20.89044110
65CAMKK20.87439330
66IRAK10.85571960
67EPHB10.84244358
68DYRK30.81265398
69NUAK10.81033972
70UHMK10.79826190
71MARK20.78785127
72CAMK2D0.78525577
73CSNK1A10.77131550
74ROCK20.76351954
75PRKD30.72840317
76DYRK1A0.71249928
77GRK50.69925234
78MAP3K140.68991093
79CSNK1A1L0.68575353
80CDK50.67457063
81FER0.65692506
82PRKD20.65377780
83PRKCQ0.64582561
84CAMK40.63279244
85CCNB10.62979191
86PLK20.62548207
87PIK3CA0.60911272
88DYRK20.60615151
89ERBB40.59559949
90PRKG10.58975588
91CDK140.58281109
92STK380.58213655
93LIMK10.57862345
94ZAK0.57502699
95CAMK10.57160433
96SIK30.57089323
97PRKCZ0.56444452
98TXK0.56328870
99WNK30.55301759
100TIE10.55264234
101MAP3K60.54920112
102TAOK10.54870819
103PAK60.54821859
104SGK20.52376307
105PRKAA20.52174626
106SGK10.51872673
107MAP3K50.51219653
108CDK180.50718724
109STK110.48870867
110PRKACA0.47997305
111CSNK1G20.47882935
112CSNK1D0.47853076
113FYN0.47684208
114CSNK1G30.47153946
115IRAK40.47042637
116BRD40.46551219
117CSNK1G10.46447312
118CAMK2G0.44560645
119PRKCG0.44473986
120PAK30.44077148
121PDK20.43476890
122ADRBK10.43352845
123MAPKAPK30.43163448
124SGK4940.43043565
125SGK2230.43043565
126TAOK30.42184014
127DYRK1B0.41165058
128AKT30.41130045
129MST40.40444491
130NTRK10.40230620
131CDK150.40156429
132PRKACB0.38474222
133CDK11A0.38245507
134PRKCI0.37934106
135IRAK30.37893151
136CAMK1D0.37241329
137RPS6KB10.36378557
138RPS6KA50.36150588
139PHKG10.35971901
140PHKG20.35971901
141EIF2AK30.30743982
142CSNK2A10.30293411
143MAPK90.30230196
144CSNK1E0.28924686
145PRKAA10.28691096
146NME10.28267755
147DAPK10.27104897
148PRKACG0.26829272

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.61085192
2Phototransduction_Homo sapiens_hsa047442.40303565
3Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.39852664
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39705529
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30355608
6Serotonergic synapse_Homo sapiens_hsa047262.24306165
7Glutamatergic synapse_Homo sapiens_hsa047242.22415650
8Morphine addiction_Homo sapiens_hsa050322.22335601
9Butanoate metabolism_Homo sapiens_hsa006502.14888310
10Taste transduction_Homo sapiens_hsa047422.14341290
11GABAergic synapse_Homo sapiens_hsa047272.05030771
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.04829007
13Ether lipid metabolism_Homo sapiens_hsa005652.01930278
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01457570
15Axon guidance_Homo sapiens_hsa043601.91488560
16RNA polymerase_Homo sapiens_hsa030201.89244699
17Basal transcription factors_Homo sapiens_hsa030221.88445205
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88306091
19Protein export_Homo sapiens_hsa030601.77450578
20Selenocompound metabolism_Homo sapiens_hsa004501.74848533
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72882421
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67614161
23Sphingolipid metabolism_Homo sapiens_hsa006001.62117380
24Fatty acid elongation_Homo sapiens_hsa000621.60860568
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60315576
26Circadian entrainment_Homo sapiens_hsa047131.58878572
27Salivary secretion_Homo sapiens_hsa049701.56466966
28Calcium signaling pathway_Homo sapiens_hsa040201.54906542
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48401945
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47187254
31Long-term depression_Homo sapiens_hsa047301.46455273
32beta-Alanine metabolism_Homo sapiens_hsa004101.40251670
33Oxidative phosphorylation_Homo sapiens_hsa001901.30594075
34Steroid biosynthesis_Homo sapiens_hsa001001.30443234
35Autoimmune thyroid disease_Homo sapiens_hsa053201.26376553
36Cocaine addiction_Homo sapiens_hsa050301.26143839
37Amphetamine addiction_Homo sapiens_hsa050311.23235725
38Renin secretion_Homo sapiens_hsa049241.23077046
39Cholinergic synapse_Homo sapiens_hsa047251.19444019
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18532544
41Collecting duct acid secretion_Homo sapiens_hsa049661.17221105
42RNA degradation_Homo sapiens_hsa030181.17081997
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16787076
44Dopaminergic synapse_Homo sapiens_hsa047281.16579731
45Sulfur metabolism_Homo sapiens_hsa009201.15860446
46Olfactory transduction_Homo sapiens_hsa047401.12522941
47Nitrogen metabolism_Homo sapiens_hsa009101.11464014
48Rheumatoid arthritis_Homo sapiens_hsa053231.08352625
49Linoleic acid metabolism_Homo sapiens_hsa005911.07358556
50Base excision repair_Homo sapiens_hsa034101.06152472
51Cardiac muscle contraction_Homo sapiens_hsa042601.05326864
52Gastric acid secretion_Homo sapiens_hsa049711.04367889
53Peroxisome_Homo sapiens_hsa041461.04045330
54Ras signaling pathway_Homo sapiens_hsa040141.03524506
55Oxytocin signaling pathway_Homo sapiens_hsa049211.03355555
56Regulation of autophagy_Homo sapiens_hsa041401.03239293
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.02370933
58cAMP signaling pathway_Homo sapiens_hsa040240.98880649
59Insulin secretion_Homo sapiens_hsa049110.98497146
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.98002571
61Arachidonic acid metabolism_Homo sapiens_hsa005900.96784539
62Alzheimers disease_Homo sapiens_hsa050100.95844851
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94673259
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94265074
65Chemical carcinogenesis_Homo sapiens_hsa052040.88108188
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87487510
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87079582
68Synaptic vesicle cycle_Homo sapiens_hsa047210.86878960
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86753773
70Pancreatic secretion_Homo sapiens_hsa049720.83421337
71Fanconi anemia pathway_Homo sapiens_hsa034600.83128627
72Long-term potentiation_Homo sapiens_hsa047200.82866381
73African trypanosomiasis_Homo sapiens_hsa051430.82696226
74Histidine metabolism_Homo sapiens_hsa003400.82494281
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81490654
76Wnt signaling pathway_Homo sapiens_hsa043100.80390521
77Ovarian steroidogenesis_Homo sapiens_hsa049130.80311787
78Melanoma_Homo sapiens_hsa052180.79966102
79Tryptophan metabolism_Homo sapiens_hsa003800.77914847
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74175762
81Mineral absorption_Homo sapiens_hsa049780.71837588
82MAPK signaling pathway_Homo sapiens_hsa040100.71531043
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71514821
84Asthma_Homo sapiens_hsa053100.71084967
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70285066
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68843035
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68607809
88Fat digestion and absorption_Homo sapiens_hsa049750.67727858
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66955945
90Rap1 signaling pathway_Homo sapiens_hsa040150.66870308
91Spliceosome_Homo sapiens_hsa030400.66823082
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.66767510
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66627176
94Propanoate metabolism_Homo sapiens_hsa006400.65937829
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65623225
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64567696
97Choline metabolism in cancer_Homo sapiens_hsa052310.63464176
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62702589
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62530255
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.62174882
101Melanogenesis_Homo sapiens_hsa049160.61254839
102Homologous recombination_Homo sapiens_hsa034400.61187686
103Sulfur relay system_Homo sapiens_hsa041220.61069469
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.60902725
105Gap junction_Homo sapiens_hsa045400.60655870
106Graft-versus-host disease_Homo sapiens_hsa053320.60292186
107Caffeine metabolism_Homo sapiens_hsa002320.60287985
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59606053
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59431875
110Parkinsons disease_Homo sapiens_hsa050120.59021699
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58793998
112Glycerolipid metabolism_Homo sapiens_hsa005610.57599871
113Oocyte meiosis_Homo sapiens_hsa041140.56373404
114GnRH signaling pathway_Homo sapiens_hsa049120.55797496
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55696290
116Vibrio cholerae infection_Homo sapiens_hsa051100.55606073
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.54777706
118ErbB signaling pathway_Homo sapiens_hsa040120.54605908
119Hedgehog signaling pathway_Homo sapiens_hsa043400.54305696
120Dorso-ventral axis formation_Homo sapiens_hsa043200.54273785
121Alcoholism_Homo sapiens_hsa050340.53965133
122Proteasome_Homo sapiens_hsa030500.53793945
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52413558
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52325953
125ABC transporters_Homo sapiens_hsa020100.52279927
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52127510
127Purine metabolism_Homo sapiens_hsa002300.52016601
128Pyrimidine metabolism_Homo sapiens_hsa002400.51742902
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51391032
130Allograft rejection_Homo sapiens_hsa053300.51010756
131Vitamin digestion and absorption_Homo sapiens_hsa049770.50802906
132Metabolic pathways_Homo sapiens_hsa011000.49971771
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.49627791
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48556881
135Fatty acid metabolism_Homo sapiens_hsa012120.46544456
136Basal cell carcinoma_Homo sapiens_hsa052170.46499488
137Malaria_Homo sapiens_hsa051440.46320075
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45854395
139Huntingtons disease_Homo sapiens_hsa050160.45537366
140Retinol metabolism_Homo sapiens_hsa008300.44884622
141Circadian rhythm_Homo sapiens_hsa047100.44849784
142Type II diabetes mellitus_Homo sapiens_hsa049300.44712336
143Phagosome_Homo sapiens_hsa041450.44175865
144Non-homologous end-joining_Homo sapiens_hsa034500.43996582
145Hematopoietic cell lineage_Homo sapiens_hsa046400.43058522
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42884938
147ECM-receptor interaction_Homo sapiens_hsa045120.41787742
148Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41112740
149RNA transport_Homo sapiens_hsa030130.39905031
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38165450
151Fatty acid biosynthesis_Homo sapiens_hsa000610.36658257
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36230328
153Mismatch repair_Homo sapiens_hsa034300.33799519
154Fatty acid degradation_Homo sapiens_hsa000710.32083467

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