DLGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.10979713
2ionotropic glutamate receptor signaling pathway (GO:0035235)5.94016825
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.81602625
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.70827014
5vocalization behavior (GO:0071625)5.65100200
6locomotory exploration behavior (GO:0035641)5.57812616
7glutamate secretion (GO:0014047)5.49092691
8synaptic vesicle exocytosis (GO:0016079)5.33804819
9glutamate receptor signaling pathway (GO:0007215)5.31756872
10regulation of glutamate receptor signaling pathway (GO:1900449)5.25863655
11synaptic transmission, glutamatergic (GO:0035249)5.20795183
12synaptic vesicle maturation (GO:0016188)5.16261287
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.14652133
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07118981
15protein localization to synapse (GO:0035418)5.05827944
16neuronal action potential propagation (GO:0019227)4.93236891
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.86969392
18neuron cell-cell adhesion (GO:0007158)4.80704690
19regulation of synaptic vesicle exocytosis (GO:2000300)4.77504036
20neuron-neuron synaptic transmission (GO:0007270)4.68530064
21amino acid import (GO:0043090)4.63638424
22exploration behavior (GO:0035640)4.58019474
23regulation of neuronal synaptic plasticity (GO:0048168)4.53438179
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52804675
25neurotransmitter-gated ion channel clustering (GO:0072578)4.49895928
26regulation of synaptic vesicle transport (GO:1902803)4.41801204
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.31085860
28gamma-aminobutyric acid signaling pathway (GO:0007214)4.30353418
29positive regulation of synapse maturation (GO:0090129)4.28686086
30long-term memory (GO:0007616)4.18179334
31neurotransmitter secretion (GO:0007269)4.14642761
32regulation of postsynaptic membrane potential (GO:0060078)4.06931206
33axon ensheathment in central nervous system (GO:0032291)4.06213537
34central nervous system myelination (GO:0022010)4.06213537
35neuronal ion channel clustering (GO:0045161)4.05045726
36neuron recognition (GO:0008038)4.03131525
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.97043757
38regulation of synaptic plasticity (GO:0048167)3.94728330
39gamma-aminobutyric acid transport (GO:0015812)3.93588818
40presynaptic membrane assembly (GO:0097105)3.92505943
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92357195
42positive regulation of membrane potential (GO:0045838)3.90122598
43potassium ion homeostasis (GO:0055075)3.85015039
44potassium ion import (GO:0010107)3.82488236
45cellular potassium ion homeostasis (GO:0030007)3.82381838
46regulation of dendritic spine morphogenesis (GO:0061001)3.82197589
47long-term synaptic potentiation (GO:0060291)3.81460014
48postsynaptic membrane organization (GO:0001941)3.79402817
49regulation of voltage-gated calcium channel activity (GO:1901385)3.79317967
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76899646
51dendritic spine morphogenesis (GO:0060997)3.69869037
52regulation of synapse structural plasticity (GO:0051823)3.68913545
53behavioral defense response (GO:0002209)3.66091282
54behavioral fear response (GO:0001662)3.66091282
55transmission of nerve impulse (GO:0019226)3.63462816
56presynaptic membrane organization (GO:0097090)3.60681067
57cellular sodium ion homeostasis (GO:0006883)3.60644758
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.60392265
59axonal fasciculation (GO:0007413)3.59672643
60positive regulation of neurotransmitter secretion (GO:0001956)3.59610554
61neurotransmitter uptake (GO:0001504)3.58752438
62synaptic vesicle endocytosis (GO:0048488)3.57780406
63negative regulation of dendrite morphogenesis (GO:0050774)3.55960264
64acidic amino acid transport (GO:0015800)3.47039700
65fear response (GO:0042596)3.46849729
66regulation of synapse maturation (GO:0090128)3.44547496
67proline transport (GO:0015824)3.44165962
68layer formation in cerebral cortex (GO:0021819)3.43095658
69membrane depolarization (GO:0051899)3.43058173
70regulation of neurotransmitter secretion (GO:0046928)3.42953609
71neurotransmitter transport (GO:0006836)3.42587373
72regulation of vesicle fusion (GO:0031338)3.42004309
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40959709
74response to histamine (GO:0034776)3.40739186
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39967375
76cerebellar Purkinje cell differentiation (GO:0021702)3.39028977
77regulation of dendritic spine development (GO:0060998)3.37649215
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34253610
79innervation (GO:0060384)3.32987469
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32691734
81cerebellar granule cell differentiation (GO:0021707)3.32665938
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.32547952
83auditory behavior (GO:0031223)3.32528922
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32386200
85startle response (GO:0001964)3.29657122
86positive regulation of dendritic spine development (GO:0060999)3.29519844
87membrane depolarization during action potential (GO:0086010)3.27094583
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25245196
89long term synaptic depression (GO:0060292)3.22854490
90neuromuscular process controlling posture (GO:0050884)3.22117047
91learning (GO:0007612)3.22006792
92response to auditory stimulus (GO:0010996)3.20714549
93dendritic spine organization (GO:0097061)3.20281538
94serotonin metabolic process (GO:0042428)3.18185354
95chemosensory behavior (GO:0007635)3.16675779
96regulation of neurotransmitter levels (GO:0001505)3.16324218
97regulation of synaptic transmission (GO:0050804)3.15819547
98neuromuscular process controlling balance (GO:0050885)3.15528449
99sodium ion export (GO:0071436)3.14723644
100positive regulation of neurotransmitter transport (GO:0051590)3.14381678
101neuromuscular synaptic transmission (GO:0007274)3.14337441
102adult walking behavior (GO:0007628)3.13871830
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12568471
104synaptic vesicle transport (GO:0048489)3.09428692
105establishment of synaptic vesicle localization (GO:0097480)3.09428692
106* synaptic transmission (GO:0007268)3.09171967
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08447693
108cell communication by electrical coupling (GO:0010644)3.08101883
109cochlea development (GO:0090102)3.07256571
110regulation of neurotransmitter transport (GO:0051588)3.07083877
111regulation of ARF protein signal transduction (GO:0032012)3.05352510
112C4-dicarboxylate transport (GO:0015740)3.05175762
113neuromuscular process (GO:0050905)3.05002055
114L-amino acid import (GO:0043092)3.04787770
115positive regulation of synaptic transmission (GO:0050806)3.04235687
116positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03603345
117cell differentiation in hindbrain (GO:0021533)3.00227166
118L-glutamate transport (GO:0015813)2.99347295
119regulation of respiratory system process (GO:0044065)2.97989984
120dendrite morphogenesis (GO:0048813)2.95324057
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95306722
122activation of protein kinase A activity (GO:0034199)2.93851139
123membrane hyperpolarization (GO:0060081)2.93321729
124synapse assembly (GO:0007416)2.92386606
125detection of calcium ion (GO:0005513)2.91415309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.64351754
2GBX2_23144817_ChIP-Seq_PC3_Human4.14762005
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14065658
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08326853
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06973846
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69557956
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68065051
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68065051
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.59748488
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59572108
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58286941
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46636058
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44101965
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.42783549
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39362512
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.39354873
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.39111950
18* DROSHA_22980978_ChIP-Seq_HELA_Human2.38164606
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.13872783
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.12745703
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10042020
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09788024
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07573106
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.03980109
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88563328
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87884241
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87419809
28* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86220654
29TAF15_26573619_Chip-Seq_HEK293_Human1.84091502
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82714291
31AR_21572438_ChIP-Seq_LNCaP_Human1.80937707
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.79713722
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76354148
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62706977
35* P300_19829295_ChIP-Seq_ESCs_Human1.58660557
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57631202
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57146821
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55223368
39ZNF274_21170338_ChIP-Seq_K562_Hela1.43646957
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43578208
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.42154325
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.42043134
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41473413
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41328794
45AR_25329375_ChIP-Seq_VCAP_Human1.40507553
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.40312524
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35677845
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35514552
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.34137387
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.32926984
51FUS_26573619_Chip-Seq_HEK293_Human1.32201715
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31475829
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30836245
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30732967
55VDR_22108803_ChIP-Seq_LS180_Human1.29708117
56* STAT3_23295773_ChIP-Seq_U87_Human1.29630315
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28904124
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28830778
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26059378
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24299299
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.22726866
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19980059
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19453037
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18445038
65* AR_19668381_ChIP-Seq_PC3_Human1.17606098
66TP53_16413492_ChIP-PET_HCT116_Human1.16094063
67* TCF4_23295773_ChIP-Seq_U87_Human1.16064533
68IGF1R_20145208_ChIP-Seq_DFB_Human1.15250602
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.13973591
70* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13439781
71* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12490306
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.10852785
73* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10648591
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10101495
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09156577
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.08736131
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07856294
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05980123
79RNF2_27304074_Chip-Seq_NSC_Mouse1.05306358
80* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04745019
81AHR_22903824_ChIP-Seq_MCF-7_Human1.04554350
82* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04479133
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04322025
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.04139380
85RUNX2_22187159_ChIP-Seq_PCA_Human1.03935652
86TP53_18474530_ChIP-ChIP_U2OS_Human1.03870504
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03342498
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02882975
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02882975
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.02683084
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01386288
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00505553
93* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00493691
94CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99794040
95JUN_21703547_ChIP-Seq_K562_Human0.99030453
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.98892389
97BCAT_22108803_ChIP-Seq_LS180_Human0.97914924
98* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96394246
99* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95853272
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93539288
101* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92518881
102TET1_21490601_ChIP-Seq_MESCs_Mouse0.92448557
103RXR_22108803_ChIP-Seq_LS180_Human0.92190199
104RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91660147
105* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91500026
106E2F1_18555785_Chip-Seq_ESCs_Mouse0.91200259
107* SOX9_26525672_Chip-Seq_HEART_Mouse0.90674039
108ER_23166858_ChIP-Seq_MCF-7_Human0.90139376
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.89965089
110KDM2B_26808549_Chip-Seq_REH_Human0.89290923
111* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88109049
112* SMAD3_21741376_ChIP-Seq_ESCs_Human0.87335236
113KDM2B_26808549_Chip-Seq_K562_Human0.87292595
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86623212
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85306262
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85081691
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84357818
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84058940
119* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83856713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.21025271
2MP0003880_abnormal_central_pattern5.70719580
3MP0003635_abnormal_synaptic_transmissio4.33107448
4MP0004270_analgesia3.64326272
5MP0009745_abnormal_behavioral_response3.61180377
6MP0002063_abnormal_learning/memory/cond3.49929377
7MP0001968_abnormal_touch/_nociception3.39178556
8MP0002064_seizures3.27692527
9MP0009046_muscle_twitch3.03423144
10MP0002572_abnormal_emotion/affect_behav2.99047541
11MP0002736_abnormal_nociception_after2.93596488
12MP0002272_abnormal_nervous_system2.74683941
13MP0002735_abnormal_chemical_nociception2.65291286
14MP0001501_abnormal_sleep_pattern2.62020740
15MP0001486_abnormal_startle_reflex2.53852109
16MP0002734_abnormal_mechanical_nocicepti2.45096050
17MP0001440_abnormal_grooming_behavior2.36538582
18MP0005423_abnormal_somatic_nervous2.30680702
19MP0002067_abnormal_sensory_capabilities2.08627181
20MP0002822_catalepsy1.99145275
21MP0002733_abnormal_thermal_nociception1.89282782
22MP0001970_abnormal_pain_threshold1.85769099
23MP0003329_amyloid_beta_deposits1.84494848
24MP0008569_lethality_at_weaning1.83319463
25MP0009780_abnormal_chondrocyte_physiolo1.82884305
26MP0002184_abnormal_innervation1.77184403
27MP0000778_abnormal_nervous_system1.74785102
28MP0003879_abnormal_hair_cell1.70452197
29MP0002557_abnormal_social/conspecific_i1.70171628
30MP0005646_abnormal_pituitary_gland1.67637297
31MP0004924_abnormal_behavior1.57791516
32MP0005386_behavior/neurological_phenoty1.57791516
33MP0004858_abnormal_nervous_system1.57678144
34MP0003787_abnormal_imprinting1.57227499
35MP0004811_abnormal_neuron_physiology1.57207223
36MP0006276_abnormal_autonomic_nervous1.48169934
37MP0000955_abnormal_spinal_cord1.48165749
38MP0002066_abnormal_motor_capabilities/c1.37950952
39MP0001984_abnormal_olfaction1.37855005
40MP0002882_abnormal_neuron_morphology1.36031852
41MP0001188_hyperpigmentation1.35706042
42MP0004885_abnormal_endolymph1.34382270
43MP0002909_abnormal_adrenal_gland1.31639016
44MP0003633_abnormal_nervous_system1.28548488
45MP0005645_abnormal_hypothalamus_physiol1.23739119
46MP0001502_abnormal_circadian_rhythm1.22801944
47MP0004145_abnormal_muscle_electrophysio1.17128960
48MP0004147_increased_porphyrin_level1.15460317
49MP0004142_abnormal_muscle_tone1.12804676
50MP0003631_nervous_system_phenotype1.12143162
51MP0001905_abnormal_dopamine_level1.11458040
52MP0001529_abnormal_vocalization1.05330847
53MP0002152_abnormal_brain_morphology1.05058456
54MP0001986_abnormal_taste_sensitivity1.00186412
55MP0002876_abnormal_thyroid_physiology0.99063052
56MP0004510_myositis0.98148717
57MP0002837_dystrophic_cardiac_calcinosis0.97154633
58MP0003123_paternal_imprinting0.96954996
59MP0000569_abnormal_digit_pigmentation0.95236928
60MP0008872_abnormal_physiological_respon0.94074623
61MP0004484_altered_response_of0.93094148
62MP0001963_abnormal_hearing_physiology0.92501908
63MP0008874_decreased_physiological_sensi0.92426914
64MP0004742_abnormal_vestibular_system0.91761018
65MP0002069_abnormal_eating/drinking_beha0.90774836
66MP0010386_abnormal_urinary_bladder0.89774028
67MP0004215_abnormal_myocardial_fiber0.89654773
68MP0005551_abnormal_eye_electrophysiolog0.88593931
69MP0006292_abnormal_olfactory_placode0.86655122
70MP0002229_neurodegeneration0.86603662
71MP0003075_altered_response_to0.84858725
72MP0001177_atelectasis0.83432634
73MP0003632_abnormal_nervous_system0.83188350
74MP0004085_abnormal_heartbeat0.82665720
75MP0000751_myopathy0.81641666
76MP0000604_amyloidosis0.80455974
77MP0005409_darkened_coat_color0.78626644
78MP0005171_absent_coat_pigmentation0.76766963
79MP0001485_abnormal_pinna_reflex0.76487545
80MP0005535_abnormal_body_temperature0.75748019
81MP0003122_maternal_imprinting0.74031788
82MP0005167_abnormal_blood-brain_barrier0.71339925
83MP0002752_abnormal_somatic_nervous0.70716207
84MP0008877_abnormal_DNA_methylation0.69332979
85MP0003690_abnormal_glial_cell0.65943557
86MP0000631_abnormal_neuroendocrine_gland0.65836026
87MP0003634_abnormal_glial_cell0.65512147
88MP0001664_abnormal_digestion0.64909949
89MP0002653_abnormal_ependyma_morphology0.64437526
90MP0001348_abnormal_lacrimal_gland0.62927116
91MP0003121_genomic_imprinting0.62315562
92MP0000920_abnormal_myelination0.61654550
93MP0001346_abnormal_lacrimal_gland0.60971907
94MP0000026_abnormal_inner_ear0.59751699
95MP0005499_abnormal_olfactory_system0.59302353
96MP0005394_taste/olfaction_phenotype0.59302353
97MP0001943_abnormal_respiration0.55750912
98MP0003137_abnormal_impulse_conducting0.55395526
99MP0003283_abnormal_digestive_organ0.55031038
100MP0000013_abnormal_adipose_tissue0.53604962
101MP0010769_abnormal_survival0.52666447
102MP0002638_abnormal_pupillary_reflex0.52285196
103MP0005623_abnormal_meninges_morphology0.52149517
104MP0001765_abnormal_ion_homeostasis0.51829761
105MP0002082_postnatal_lethality0.51055362
106MP0010770_preweaning_lethality0.51055362
107MP0003861_abnormal_nervous_system0.51025964
108MP0003938_abnormal_ear_development0.50706035
109MP0010768_mortality/aging0.49618539
110MP0003956_abnormal_body_size0.49042933
111MP0008961_abnormal_basal_metabolism0.48386988
112MP0004043_abnormal_pH_regulation0.48350581
113MP0002090_abnormal_vision0.48053249
114MP0001299_abnormal_eye_distance/0.47064527
115MP0004130_abnormal_muscle_cell0.47043620
116MP0003183_abnormal_peptide_metabolism0.47001153

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.68718544
2Myokymia (HP:0002411)6.52216780
3Focal seizures (HP:0007359)6.42780073
4Epileptic encephalopathy (HP:0200134)5.73697880
5Visual hallucinations (HP:0002367)5.54363267
6Febrile seizures (HP:0002373)5.42006328
7Atonic seizures (HP:0010819)5.40962597
8Progressive cerebellar ataxia (HP:0002073)4.82099643
9Absence seizures (HP:0002121)4.66569374
10Hyperventilation (HP:0002883)4.53427502
11Dialeptic seizures (HP:0011146)4.43995717
12Generalized tonic-clonic seizures (HP:0002069)4.27395782
13Broad-based gait (HP:0002136)4.09292063
14Gaze-evoked nystagmus (HP:0000640)3.95837744
15Action tremor (HP:0002345)3.74835762
16Poor eye contact (HP:0000817)3.57029958
17Amblyopia (HP:0000646)3.51177376
18Dysdiadochokinesis (HP:0002075)3.36237588
19Dysmetria (HP:0001310)3.30645186
20Limb dystonia (HP:0002451)3.29753167
21Impaired vibration sensation in the lower limbs (HP:0002166)3.23209831
22Cerebral hypomyelination (HP:0006808)3.17544506
23Impaired social interactions (HP:0000735)3.13094305
24Abnormal social behavior (HP:0012433)3.13094305
25Supranuclear gaze palsy (HP:0000605)3.11988447
26Excessive salivation (HP:0003781)3.07136761
27Drooling (HP:0002307)3.07136761
28Truncal ataxia (HP:0002078)3.06966977
29Impaired smooth pursuit (HP:0007772)3.05278442
30Hemiparesis (HP:0001269)2.96745183
31Abnormality of binocular vision (HP:0011514)2.96519249
32Diplopia (HP:0000651)2.96519249
33Genetic anticipation (HP:0003743)2.95158309
34Epileptiform EEG discharges (HP:0011182)2.93977993
35Absent speech (HP:0001344)2.93701275
36Depression (HP:0000716)2.85232489
37Abnormality of the lower motor neuron (HP:0002366)2.84588710
38Scanning speech (HP:0002168)2.83586153
39Tetraplegia (HP:0002445)2.81551646
40Anxiety (HP:0000739)2.77260525
41Postural instability (HP:0002172)2.74672349
42Cerebral inclusion bodies (HP:0100314)2.69838465
43Abnormal eating behavior (HP:0100738)2.66157633
44Urinary bladder sphincter dysfunction (HP:0002839)2.65332303
45Peripheral hypomyelination (HP:0007182)2.64397645
46Abnormality of ocular smooth pursuit (HP:0000617)2.62437148
47EEG with generalized epileptiform discharges (HP:0011198)2.58225635
48Akinesia (HP:0002304)2.55521476
49Clonus (HP:0002169)2.52981931
50Status epilepticus (HP:0002133)2.52821815
51Protruding tongue (HP:0010808)2.51717698
52Hemiplegia (HP:0002301)2.50866325
53Stereotypic behavior (HP:0000733)2.50089468
54Neurofibrillary tangles (HP:0002185)2.49603660
55Neuronal loss in central nervous system (HP:0002529)2.43335166
56Bradykinesia (HP:0002067)2.40950788
57Dysmetric saccades (HP:0000641)2.40352023
58Hypsarrhythmia (HP:0002521)2.38563939
59Split foot (HP:0001839)2.34319524
60Sleep apnea (HP:0010535)2.33659203
61Inability to walk (HP:0002540)2.32751124
62Ankle clonus (HP:0011448)2.30832757
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.29954920
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29954920
65Impaired vibratory sensation (HP:0002495)2.28930979
66Craniofacial dystonia (HP:0012179)2.28773072
67Generalized myoclonic seizures (HP:0002123)2.26343416
68Fetal akinesia sequence (HP:0001989)2.25431951
69Blue irides (HP:0000635)2.23679345
70Mutism (HP:0002300)2.22747178
71Progressive inability to walk (HP:0002505)2.19844480
72Intention tremor (HP:0002080)2.19584797
73Spastic gait (HP:0002064)2.15690082
74Urinary urgency (HP:0000012)2.12008834
75Abnormality of salivation (HP:0100755)2.11139657
76Apathy (HP:0000741)2.10420079
77Spastic tetraparesis (HP:0001285)2.06562776
78CNS hypomyelination (HP:0003429)2.06053039
79Morphological abnormality of the pyramidal tract (HP:0002062)2.05693784
80Gait ataxia (HP:0002066)2.04679263
81Papilledema (HP:0001085)2.01287952
82Amyotrophic lateral sclerosis (HP:0007354)2.00478377
83Incomplete penetrance (HP:0003829)1.99345765
84Choreoathetosis (HP:0001266)1.98371195
85Thickened helices (HP:0000391)1.97679461
86Generalized hypopigmentation of hair (HP:0011358)1.95567126
87Delusions (HP:0000746)1.94393108
88Fair hair (HP:0002286)1.93514910
89Focal dystonia (HP:0004373)1.92671821
90Spastic tetraplegia (HP:0002510)1.92101967
91Termporal pattern (HP:0011008)1.91657502
92Insidious onset (HP:0003587)1.91657502
93Obstructive sleep apnea (HP:0002870)1.89478717
94Type II lissencephaly (HP:0007260)1.86533212
95Torticollis (HP:0000473)1.85757661
96Widely spaced teeth (HP:0000687)1.84790190
97Ventricular fibrillation (HP:0001663)1.82710581
98Psychosis (HP:0000709)1.82526729
99Diminished motivation (HP:0000745)1.82320684
100Annular pancreas (HP:0001734)1.82246549
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80843198
102Megalencephaly (HP:0001355)1.80384103
103Abnormality of the corticospinal tract (HP:0002492)1.80191589
104Insomnia (HP:0100785)1.78031401
105Inappropriate behavior (HP:0000719)1.77123282
106Lower limb muscle weakness (HP:0007340)1.76896354
107Deeply set eye (HP:0000490)1.75752020
108Polyphagia (HP:0002591)1.75702715
109Decreased circulating renin level (HP:0003351)1.75172439
110Abnormality of saccadic eye movements (HP:0000570)1.75032874
111Clumsiness (HP:0002312)1.74947813
112Rapidly progressive (HP:0003678)1.72870395
113Lower limb asymmetry (HP:0100559)1.69877282
114Hypoplasia of the corpus callosum (HP:0002079)1.68907622
115Hypoventilation (HP:0002791)1.67972177
116Paraplegia (HP:0010550)1.67496447
117Agitation (HP:0000713)1.67410883
118Increased circulating renin level (HP:0000848)1.67252949
119Autism (HP:0000717)1.66669896
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.66011674
121Absent/shortened dynein arms (HP:0200106)1.66011674
122Spastic paraplegia (HP:0001258)1.65926731
123Gastroesophageal reflux (HP:0002020)1.65207509
124Bundle branch block (HP:0011710)1.65090408
125Retinal dysplasia (HP:0007973)1.64901359
126Rigidity (HP:0002063)1.64784087
127Syncope (HP:0001279)1.64557717
128Prolonged QT interval (HP:0001657)1.63418293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.65125623
2NTRK35.50919938
3MAP3K93.01770103
4MAP3K42.99496140
5MAP2K72.78488175
6RIPK42.75324801
7CASK2.68584982
8DAPK22.54555531
9MINK12.29328282
10TNIK2.20295228
11MARK11.97733661
12PAK61.94676456
13DAPK11.93997020
14MAP3K121.92616821
15MAP2K41.85485210
16PLK21.84365047
17PRPF4B1.80943307
18NTRK21.71088232
19KSR21.68921382
20CAMKK11.63621627
21PRKD31.61577228
22KSR11.53262035
23FES1.50297758
24CDK191.47363700
25CDK51.45251404
26NTRK11.41498705
27GRK51.38116824
28PNCK1.37335168
29PRKCG1.35513778
30BMPR21.34286695
31SIK21.33898232
32MAPK131.32512500
33MAP3K131.31717115
34STK381.30638610
35CAMK2A1.21451362
36PTK2B1.21230180
37CAMK2B1.21045809
38ARAF1.11402676
39CAMKK21.04597642
40CAMK11.04457869
41NME10.87695039
42SGK20.85226387
43MAP3K20.84998727
44OXSR10.83320903
45SGK4940.82130389
46SGK2230.82130389
47TYRO30.81691103
48RAF10.81090528
49PKN10.80248098
50AKT30.79609879
51UHMK10.78419431
52RIPK10.78104032
53CDK180.77693508
54FGR0.76992379
55PINK10.75322454
56CDK150.75084060
57DYRK1A0.74795247
58CCNB10.71126022
59FER0.70447942
60CDK140.70084974
61STK110.69652400
62FRK0.68870122
63CAMK2D0.67052827
64FGFR20.66040907
65CDK11A0.65119193
66* SGK10.64829062
67MARK20.63446056
68PRKCE0.61452016
69MAP3K60.61057039
70SGK30.60974971
71MAP3K70.60244112
72PDK10.59357311
73PAK30.58265269
74PRKCH0.57938079
75TNK20.56800725
76WNK10.55745444
77RET0.54383716
78PHKG10.53549252
79PHKG20.53549252
80CAMK2G0.53348106
81PDPK10.51706122
82BRSK10.50897203
83WNK30.48568310
84SIK30.48081979
85NEK60.48005082
86MAP3K10.47979168
87CAMK40.46359485
88CAMK1G0.44872771
89LATS20.44872242
90TAOK10.43654863
91CSNK1G20.42131829
92* RPS6KA30.41422844
93BRAF0.39206442
94FYN0.38194671
95PRKCZ0.38085097
96CDC42BPA0.37522534
97MAP2K10.37295195
98MAPK100.37289647
99ROCK20.36814173
100CSNK1D0.36353810
101DMPK0.35532993
102MUSK0.35505364
103MAPK120.35163694
104PRKCA0.33470362
105DAPK30.33450788
106CSNK1A1L0.33219029
107CSNK1A10.32776610
108ALK0.29650542
109PRKACA0.29496522
110* PRKCB0.29051925
111GRK70.28282280
112PRKG10.28095800
113MAPK80.26810716
114ERBB20.26042561
115CSNK1G30.24839994
116* GSK3B0.24517905

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.48284332
2Long-term potentiation_Homo sapiens_hsa047203.16068978
3Synaptic vesicle cycle_Homo sapiens_hsa047213.08003854
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.97436153
5Circadian entrainment_Homo sapiens_hsa047132.94802974
6* Glutamatergic synapse_Homo sapiens_hsa047242.84007241
7Amphetamine addiction_Homo sapiens_hsa050312.77603460
8GABAergic synapse_Homo sapiens_hsa047272.67257454
9Morphine addiction_Homo sapiens_hsa050322.57009290
10Olfactory transduction_Homo sapiens_hsa047402.47076927
11Salivary secretion_Homo sapiens_hsa049702.34882922
12Dopaminergic synapse_Homo sapiens_hsa047282.16411686
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06186174
14Insulin secretion_Homo sapiens_hsa049112.03845716
15Taste transduction_Homo sapiens_hsa047422.03705501
16Long-term depression_Homo sapiens_hsa047301.94582396
17Gastric acid secretion_Homo sapiens_hsa049711.90823262
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90696182
19Calcium signaling pathway_Homo sapiens_hsa040201.83020578
20Cholinergic synapse_Homo sapiens_hsa047251.78861837
21Oxytocin signaling pathway_Homo sapiens_hsa049211.73298892
22Renin secretion_Homo sapiens_hsa049241.72362439
23Serotonergic synapse_Homo sapiens_hsa047261.71653947
24Collecting duct acid secretion_Homo sapiens_hsa049661.58669937
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54642943
26Cocaine addiction_Homo sapiens_hsa050301.47197995
27GnRH signaling pathway_Homo sapiens_hsa049121.44230858
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41175381
29cAMP signaling pathway_Homo sapiens_hsa040241.38662279
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25644823
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24774624
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24035511
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21560554
34Gap junction_Homo sapiens_hsa045401.19225092
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18302857
36Type II diabetes mellitus_Homo sapiens_hsa049301.13400141
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13311404
38Axon guidance_Homo sapiens_hsa043601.11231172
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10146448
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08453863
41Vitamin B6 metabolism_Homo sapiens_hsa007501.08376872
42Estrogen signaling pathway_Homo sapiens_hsa049151.08350504
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06200958
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05877380
45Glioma_Homo sapiens_hsa052141.05505715
46Melanogenesis_Homo sapiens_hsa049161.01710293
47ErbB signaling pathway_Homo sapiens_hsa040120.99448272
48Vibrio cholerae infection_Homo sapiens_hsa051100.97577887
49Pancreatic secretion_Homo sapiens_hsa049720.97218910
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.92760286
51Cardiac muscle contraction_Homo sapiens_hsa042600.86820533
52Choline metabolism in cancer_Homo sapiens_hsa052310.80970010
53Oocyte meiosis_Homo sapiens_hsa041140.78763936
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.78374957
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77120040
56Thyroid hormone synthesis_Homo sapiens_hsa049180.76231672
57Phototransduction_Homo sapiens_hsa047440.76151790
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75323544
59Dorso-ventral axis formation_Homo sapiens_hsa043200.73089236
60MAPK signaling pathway_Homo sapiens_hsa040100.68054320
61Dilated cardiomyopathy_Homo sapiens_hsa054140.67652857
62VEGF signaling pathway_Homo sapiens_hsa043700.62325429
63Glucagon signaling pathway_Homo sapiens_hsa049220.61660607
64African trypanosomiasis_Homo sapiens_hsa051430.61145576
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58143254
66Ras signaling pathway_Homo sapiens_hsa040140.55232222
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55144275
68Inositol phosphate metabolism_Homo sapiens_hsa005620.55033772
69Circadian rhythm_Homo sapiens_hsa047100.54303696
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52320963
71Nitrogen metabolism_Homo sapiens_hsa009100.51431380
72Rap1 signaling pathway_Homo sapiens_hsa040150.51235967
73Fatty acid biosynthesis_Homo sapiens_hsa000610.49730915
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48844511
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.47598658
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45552960
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44743913
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44609829
79Wnt signaling pathway_Homo sapiens_hsa043100.44555168
80Type I diabetes mellitus_Homo sapiens_hsa049400.43291615
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.42586632
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41456344
83beta-Alanine metabolism_Homo sapiens_hsa004100.41349636
84Alzheimers disease_Homo sapiens_hsa050100.40764042
85Bile secretion_Homo sapiens_hsa049760.40159227
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39841255
87mTOR signaling pathway_Homo sapiens_hsa041500.37414973
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31250516
89Histidine metabolism_Homo sapiens_hsa003400.31167858
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30635162
91Arginine and proline metabolism_Homo sapiens_hsa003300.30146064
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30069301
93Alcoholism_Homo sapiens_hsa050340.29440058
94Ovarian steroidogenesis_Homo sapiens_hsa049130.29230560
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28848826
96Hippo signaling pathway_Homo sapiens_hsa043900.26403055
97Prion diseases_Homo sapiens_hsa050200.26390521
98Non-small cell lung cancer_Homo sapiens_hsa052230.26384166
99Endocytosis_Homo sapiens_hsa041440.25976169
100Butanoate metabolism_Homo sapiens_hsa006500.25456566
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25024159
102Mineral absorption_Homo sapiens_hsa049780.24825658
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24015292
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23978606
105Tight junction_Homo sapiens_hsa045300.23221888
106Chemokine signaling pathway_Homo sapiens_hsa040620.22548198
107Insulin signaling pathway_Homo sapiens_hsa049100.22308059
108Rheumatoid arthritis_Homo sapiens_hsa053230.22211627
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.21649767
110AMPK signaling pathway_Homo sapiens_hsa041520.20875347
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20190024
112Arginine biosynthesis_Homo sapiens_hsa002200.20033072
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18646665
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16602425

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