DLG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.35430382
2desmosome organization (GO:0002934)4.34271051
3hippo signaling (GO:0035329)4.20857001
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.16413395
5regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07174756
6regulation of hippo signaling (GO:0035330)3.85559302
7chondrocyte proliferation (GO:0035988)3.84401544
8bone trabecula formation (GO:0060346)3.51261715
9negative regulation of catenin import into nucleus (GO:0035414)3.47210260
10anterior/posterior axis specification, embryo (GO:0008595)3.45952588
11dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.42554829
12notochord development (GO:0030903)3.25567230
13negative regulation of chondrocyte differentiation (GO:0032331)3.25330070
14establishment of apical/basal cell polarity (GO:0035089)3.23761403
15axon extension involved in axon guidance (GO:0048846)3.17244912
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.17244912
17protein heterotrimerization (GO:0070208)3.16397800
18lateral sprouting from an epithelium (GO:0060601)3.10166344
19craniofacial suture morphogenesis (GO:0097094)3.08113228
20semaphorin-plexin signaling pathway (GO:0071526)3.05504417
21Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.04295153
22regulation of establishment of planar polarity (GO:0090175)3.03546340
23gastrulation with mouth forming second (GO:0001702)3.02166386
24pre-miRNA processing (GO:0031054)2.98402893
25insulin-like growth factor receptor signaling pathway (GO:0048009)2.98115069
26cytoskeletal anchoring at plasma membrane (GO:0007016)2.97545022
27plasma membrane repair (GO:0001778)2.94513106
28establishment or maintenance of monopolar cell polarity (GO:0061339)2.93779684
29establishment of monopolar cell polarity (GO:0061162)2.93779684
30body morphogenesis (GO:0010171)2.91855021
31outer ear morphogenesis (GO:0042473)2.90999968
32collagen fibril organization (GO:0030199)2.87939276
33heterochromatin organization (GO:0070828)2.87729271
34convergent extension (GO:0060026)2.86173718
35non-canonical Wnt signaling pathway (GO:0035567)2.82384083
36epithelial cell-cell adhesion (GO:0090136)2.80681825
37head development (GO:0060322)2.80673874
38regulation of axon guidance (GO:1902667)2.80142937
39dorsal/ventral axis specification (GO:0009950)2.80041932
40proximal/distal pattern formation (GO:0009954)2.79240100
41endocardial cushion development (GO:0003197)2.77928757
42regulation of catenin import into nucleus (GO:0035412)2.77077926
43embryonic foregut morphogenesis (GO:0048617)2.76059014
44endodermal cell differentiation (GO:0035987)2.75098455
45* polarized epithelial cell differentiation (GO:0030859)2.72396977
46lung-associated mesenchyme development (GO:0060484)2.71398932
47negative regulation of cartilage development (GO:0061037)2.71085358
48cochlea morphogenesis (GO:0090103)2.70468431
49regulation of gene silencing by RNA (GO:0060966)2.67949578
50regulation of posttranscriptional gene silencing (GO:0060147)2.67949578
51regulation of gene silencing by miRNA (GO:0060964)2.67949578
52metanephric mesenchyme development (GO:0072075)2.67321336
53negative regulation of keratinocyte proliferation (GO:0010839)2.66341621
54negative regulation of fatty acid transport (GO:2000192)2.63453153
55cell migration involved in sprouting angiogenesis (GO:0002042)2.63115799
56glucocorticoid receptor signaling pathway (GO:0042921)2.62589495
57G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.59389441
58regulation of tight junction assembly (GO:2000810)2.59188364
59regulation of water loss via skin (GO:0033561)2.58400517
60skin morphogenesis (GO:0043589)2.56869260
61axon extension (GO:0048675)2.56464992
62mesenchyme development (GO:0060485)2.54684700
63negative regulation of axon guidance (GO:1902668)2.54477052
64cell migration in hindbrain (GO:0021535)2.53537995
65axonal fasciculation (GO:0007413)2.52937464
66kidney mesenchyme development (GO:0072074)2.52561118
67* apical protein localization (GO:0045176)2.52521140
68embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51235369
69embryonic camera-type eye development (GO:0031076)2.51195602
70embryonic cranial skeleton morphogenesis (GO:0048701)2.50895516
71gap junction assembly (GO:0016264)2.50033593
72endothelial cell chemotaxis (GO:0035767)2.50015399
73anatomical structure regression (GO:0060033)2.49978637
74embryonic body morphogenesis (GO:0010172)2.47725092
75positive regulation of SMAD protein import into nucleus (GO:0060391)2.47272122
76hemidesmosome assembly (GO:0031581)2.47078692
77sequestering of extracellular ligand from receptor (GO:0035581)2.47037957
78establishment of nucleus localization (GO:0040023)2.46844446
79organ induction (GO:0001759)2.46472959
80layer formation in cerebral cortex (GO:0021819)2.45248072
81bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45007095
82regulation of SMAD protein import into nucleus (GO:0060390)2.44850295
83mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44576609
84establishment of skin barrier (GO:0061436)2.42988131
85hindlimb morphogenesis (GO:0035137)2.42660152
86ganglion development (GO:0061548)2.41240723
87basement membrane organization (GO:0071711)2.40065613
88ear development (GO:0043583)2.38876569
89cell migration involved in gastrulation (GO:0042074)2.38791877
90regulation of transforming growth factor beta2 production (GO:0032909)2.38712677
91ectodermal placode formation (GO:0060788)2.37838496
92bone morphogenesis (GO:0060349)2.37626844
93* adherens junction assembly (GO:0034333)2.37430144
94branching involved in salivary gland morphogenesis (GO:0060445)2.37077282
95positive regulation of epithelial to mesenchymal transition (GO:0010718)2.36884428
96NLS-bearing protein import into nucleus (GO:0006607)2.34847522
97heart morphogenesis (GO:0003007)2.34031835
98mesenchymal-epithelial cell signaling (GO:0060638)2.33255988
99* asymmetric protein localization (GO:0008105)2.32777409
100* establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.32646277
101establishment of tissue polarity (GO:0007164)2.32159005
102establishment of planar polarity (GO:0001736)2.32159005
103neuron recognition (GO:0008038)2.31979627
104embryonic skeletal joint morphogenesis (GO:0060272)2.31617206
105regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.31362828
106embryonic hindlimb morphogenesis (GO:0035116)2.31219459
107neural tube closure (GO:0001843)2.30474932
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.30368205
109* establishment or maintenance of bipolar cell polarity (GO:0061245)2.30350285
110* establishment or maintenance of apical/basal cell polarity (GO:0035088)2.30350285
111regulation of axon extension involved in axon guidance (GO:0048841)2.29634426
112cell-substrate junction assembly (GO:0007044)2.29218749
113negative regulation of axon extension involved in axon guidance (GO:0048843)2.29097024
114tube closure (GO:0060606)2.28032673
115regulation of cell fate specification (GO:0042659)2.27264597
116negative regulation of embryonic development (GO:0045992)2.27097001
117negative regulation of DNA repair (GO:0045738)2.26167552
118response to follicle-stimulating hormone (GO:0032354)2.26086505
119regulation of cardioblast differentiation (GO:0051890)2.25999771
120renal system development (GO:0072001)2.25467798
121glial cell proliferation (GO:0014009)2.25122970
122regulation of cartilage development (GO:0061035)2.24813771
123myoblast fusion (GO:0007520)2.24497639
124regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.24100558
125neuron projection extension (GO:1990138)2.23822330
126lens morphogenesis in camera-type eye (GO:0002089)2.23212865
127regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.23039780
128regulation of chondrocyte differentiation (GO:0032330)2.21929670
129camera-type eye morphogenesis (GO:0048593)2.21426285
130vascular endothelial growth factor signaling pathway (GO:0038084)2.21374313
131keratinocyte development (GO:0003334)2.19329602
132regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.17892036
133morphogenesis of an epithelial sheet (GO:0002011)2.17759161
134glucocorticoid biosynthetic process (GO:0006704)2.17020918
135eye morphogenesis (GO:0048592)2.16911831
136ephrin receptor signaling pathway (GO:0048013)2.15956762
137branching involved in mammary gland duct morphogenesis (GO:0060444)2.14388735
138cell-substrate adherens junction assembly (GO:0007045)2.13929420
139focal adhesion assembly (GO:0048041)2.13929420
140atrioventricular valve morphogenesis (GO:0003181)2.13528530
141lung epithelium development (GO:0060428)2.12168947
142hair follicle development (GO:0001942)2.12128618
143neural tube development (GO:0021915)2.11334887
144* adherens junction organization (GO:0034332)2.08103722
145regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.08021060
146ectoderm development (GO:0007398)2.07260382
147presynaptic membrane assembly (GO:0097105)2.07090435
148developmental cell growth (GO:0048588)2.06249725
149cardiac right ventricle morphogenesis (GO:0003215)2.06096140
150regulation of keratinocyte proliferation (GO:0010837)2.05856831
151positive regulation of smoothened signaling pathway (GO:0045880)2.05075978
152anatomical structure arrangement (GO:0048532)2.04597634
153cell surface receptor signaling pathway involved in heart development (GO:0061311)2.04133537
154negative regulation of cell fate specification (GO:0009996)2.03979902
155embryonic eye morphogenesis (GO:0048048)2.03722887
156facial nerve structural organization (GO:0021612)2.03642797
157negative regulation of stem cell proliferation (GO:2000647)2.02035825
158limb bud formation (GO:0060174)2.00161669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.92021021
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.89081063
3* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.77303881
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.76517967
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.42119330
6WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40062549
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39593878
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30652967
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26139061
10ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.25587749
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24746760
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21637997
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.18317465
14ZFP281_27345836_Chip-Seq_ESCs_Mouse2.15471734
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11782035
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09684389
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.02426960
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.01604968
19* ESR1_20079471_ChIP-ChIP_T-47D_Human1.99726220
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.93669630
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.93669630
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.93669630
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92004611
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90344124
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.83119938
26* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77764261
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.77674247
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74241712
29TP53_20018659_ChIP-ChIP_R1E_Mouse1.71944777
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.71815717
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69901030
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69582722
33ISL1_27105846_Chip-Seq_CPCs_Mouse1.69050876
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68562092
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.67882817
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.64842991
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62699232
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.62556403
39CLOCK_20551151_ChIP-Seq_293T_Human1.61930318
40* KDM2B_26808549_Chip-Seq_K562_Human1.59541458
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52662129
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.50762056
43* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49793485
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48966664
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48966664
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.47708268
47* ARNT_22903824_ChIP-Seq_MCF-7_Human1.45802591
48TCF3_18692474_ChIP-Seq_MESCs_Mouse1.44814275
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42826305
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42758299
51AR_21909140_ChIP-Seq_LNCAP_Human1.41847309
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41085607
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.39022419
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38599191
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.38262576
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37553278
57* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34922909
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31544092
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31033762
60TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.30373993
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29517905
62BRD4_25478319_ChIP-Seq_HGPS_Human1.28190081
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.26880331
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.26054538
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23384070
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22205765
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22010808
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21924467
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.21729109
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.21245524
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.21026501
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20141448
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19963153
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19909628
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.19808006
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19558690
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.18839802
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.18131661
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.16793555
80* TP53_23651856_ChIP-Seq_MEFs_Mouse1.16311575
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15923667
82TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15496887
83POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15251040
84KDM2B_26808549_Chip-Seq_JURKAT_Human1.14937735
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.14721669
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.13922310
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13885213
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13857036
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13368328
90* KDM2B_26808549_Chip-Seq_DND41_Human1.13324951
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12860932
92ZNF263_19887448_ChIP-Seq_K562_Human1.12210762
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12073541
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11681005
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.11347694
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11329355
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11275124
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11265486
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09522166
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08778609
101TP53_22127205_ChIP-Seq_IMR90_Human1.08536138
102* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08511613
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.08071760
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06852250
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05786994
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05335234
107CREB1_26743006_Chip-Seq_LNCaP_Human1.05055944
108* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04783031
109YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04311221
110ATF3_27146783_Chip-Seq_COLON_Human1.04125091
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03898310
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03734594
113* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01563150
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01425010
115MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01274662
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01166414
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00823748
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00708822
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00708822
120AHR_22903824_ChIP-Seq_MCF-7_Human1.00032436
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99775089
122NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98607852
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98143208
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97900041
125KLF5_25053715_ChIP-Seq_YYC3_Human0.97510432
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97508504
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.97491198
128* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95161334
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.93705497
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91351194
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89618758
132CTCF_27219007_Chip-Seq_Bcells_Human0.89501647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.46773266
2MP0010030_abnormal_orbit_morphology3.32885473
3MP0008438_abnormal_cutaneous_collagen3.13596449
4MP0000566_synostosis2.85258967
5MP0005623_abnormal_meninges_morphology2.62376855
6MP0000537_abnormal_urethra_morphology2.52694087
7MP0004272_abnormal_basement_membrane2.42798071
8MP0005503_abnormal_tendon_morphology2.41277493
9MP0003283_abnormal_digestive_organ2.34839211
10MP0003122_maternal_imprinting2.34373377
11MP0009053_abnormal_anal_canal2.31195147
12MP0003385_abnormal_body_wall2.23010175
13MP0005275_abnormal_skin_tensile2.13033812
14MP0003123_paternal_imprinting2.03947502
15MP0010352_gastrointestinal_tract_polyps1.95098361
16MP0002796_impaired_skin_barrier1.92469963
17MP0003942_abnormal_urinary_system1.91203151
18MP0005076_abnormal_cell_differentiation1.86271209
19MP0000428_abnormal_craniofacial_morphol1.81286002
20MP0009250_abnormal_appendicular_skeleto1.79329038
21MP0005409_darkened_coat_color1.75441782
22MP0003755_abnormal_palate_morphology1.73668170
23MP0003121_genomic_imprinting1.73243799
24MP0003937_abnormal_limbs/digits/tail_de1.70908452
25MP0003279_aneurysm1.68651303
26MP0003119_abnormal_digestive_system1.67762899
27* MP0000534_abnormal_ureter_morphology1.66809957
28MP0000049_abnormal_middle_ear1.66148270
29MP0003115_abnormal_respiratory_system1.66142291
30MP0009384_cardiac_valve_regurgitation1.63715996
31MP0000733_abnormal_muscle_development1.63712585
32MP0004858_abnormal_nervous_system1.61185513
33MP0003935_abnormal_craniofacial_develop1.60072039
34MP0005508_abnormal_skeleton_morphology1.59918178
35MP0003941_abnormal_skin_development1.58862825
36MP0002249_abnormal_larynx_morphology1.55833965
37MP0001849_ear_inflammation1.53193822
38MP0003566_abnormal_cell_adhesion1.51249781
39MP0002932_abnormal_joint_morphology1.51160332
40MP0002098_abnormal_vibrissa_morphology1.50163983
41MP0000383_abnormal_hair_follicle1.47395598
42MP0001299_abnormal_eye_distance/1.45016645
43MP0005248_abnormal_Harderian_gland1.44653085
44MP0004233_abnormal_muscle_weight1.40582180
45MP0002116_abnormal_craniofacial_bone1.40453204
46MP0002084_abnormal_developmental_patter1.40066949
47MP0010678_abnormal_skin_adnexa1.39521389
48MP0004197_abnormal_fetal_growth/weight/1.38588808
49MP0005187_abnormal_penis_morphology1.37085949
50MP0005257_abnormal_intraocular_pressure1.35222450
51MP0003890_abnormal_embryonic-extraembry1.34962077
52MP0002233_abnormal_nose_morphology1.33003545
53* MP0000432_abnormal_head_morphology1.31862661
54MP0000762_abnormal_tongue_morphology1.28638409
55MP0002085_abnormal_embryonic_tissue1.25699611
56MP0000467_abnormal_esophagus_morphology1.25688888
57MP0002282_abnormal_trachea_morphology1.25001014
58MP0000516_abnormal_urinary_system1.23736518
59MP0005367_renal/urinary_system_phenotyp1.23736518
60MP0005501_abnormal_skin_physiology1.23487570
61MP0010234_abnormal_vibrissa_follicle1.22780008
62MP0001293_anophthalmia1.22356906
63MP0002896_abnormal_bone_mineralization1.22337191
64MP0003091_abnormal_cell_migration1.22058524
65MP0004264_abnormal_extraembryonic_tissu1.17765206
66MP0001958_emphysema1.17604934
67MP0002697_abnormal_eye_size1.17019723
68MP0000647_abnormal_sebaceous_gland1.13861878
69MP0000377_abnormal_hair_follicle1.10631778
70MP0002111_abnormal_tail_morphology1.09881484
71MP0000163_abnormal_cartilage_morphology1.09735227
72MP0009780_abnormal_chondrocyte_physiolo1.09471502
73MP0002089_abnormal_postnatal_growth/wei1.09199949
74MP0005023_abnormal_wound_healing1.08244403
75* MP0003861_abnormal_nervous_system1.07161054
76MP0006054_spinal_hemorrhage1.06854676
77MP0002234_abnormal_pharynx_morphology1.05889282
78MP0000678_abnormal_parathyroid_gland1.04611762
79MP0002925_abnormal_cardiovascular_devel1.04301248
80MP0002909_abnormal_adrenal_gland1.04085925
81MP0005380_embryogenesis_phenotype1.03883657
82MP0001672_abnormal_embryogenesis/_devel1.03883657
83MP0002108_abnormal_muscle_morphology1.03597088
84MP0004133_heterotaxia1.03365059
85MP0002114_abnormal_axial_skeleton1.02318603
86MP0002109_abnormal_limb_morphology1.02315694
87MP0001348_abnormal_lacrimal_gland1.02166624
88MP0002092_abnormal_eye_morphology0.99969686
89MP0002088_abnormal_embryonic_growth/wei0.99596140
90MP0009672_abnormal_birth_weight0.99382321
91MP0003984_embryonic_growth_retardation0.99063907
92MP0002086_abnormal_extraembryonic_tissu0.98942104
93MP0003315_abnormal_perineum_morphology0.98401247
94MP0000751_myopathy0.97275311
95MP0002877_abnormal_melanocyte_morpholog0.96956887
96MP0002184_abnormal_innervation0.96079875
97MP0000427_abnormal_hair_cycle0.95854881
98MP0004782_abnormal_surfactant_physiolog0.95665476
99MP0000462_abnormal_digestive_system0.94996025
100MP0009703_decreased_birth_body0.94814478
101MP0001177_atelectasis0.92333682
102MP0002938_white_spotting0.91729368
103MP0000778_abnormal_nervous_system0.90796554
104MP0001697_abnormal_embryo_size0.90399314
105MP0002115_abnormal_skeleton_extremities0.90077632
106MP0010771_integument_phenotype0.89854089
107MP0004270_analgesia0.89595821
108MP0001286_abnormal_eye_development0.88490301
109MP0003567_abnormal_fetal_cardiomyocyte0.87913983
110MP0008789_abnormal_olfactory_epithelium0.86717947
111MP0004859_abnormal_synaptic_plasticity0.83009476
112MP0002081_perinatal_lethality0.82821107
113MP0000569_abnormal_digit_pigmentation0.82760210
114MP0001216_abnormal_epidermal_layer0.82263246
115MP0003453_abnormal_keratinocyte_physiol0.82113876
116MP0001340_abnormal_eyelid_morphology0.81884614
117MP0002254_reproductive_system_inflammat0.81640932
118MP0001730_embryonic_growth_arrest0.80640679
119MP0003938_abnormal_ear_development0.80169308
120MP0002060_abnormal_skin_morphology0.79731854
121MP0003936_abnormal_reproductive_system0.78795964
122MP0000003_abnormal_adipose_tissue0.78655082
123MP0002177_abnormal_outer_ear0.78636021
124MP0000579_abnormal_nail_morphology0.77270353
125MP0004134_abnormal_chest_morphology0.76901990
126MP0005394_taste/olfaction_phenotype0.76504811
127MP0005499_abnormal_olfactory_system0.76504811
128MP0000350_abnormal_cell_proliferation0.75841711

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.54493059
2Shallow orbits (HP:0000586)4.18202611
3Premature rupture of membranes (HP:0001788)3.71423722
4Short 4th metacarpal (HP:0010044)3.32323401
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.32323401
6Ankle contracture (HP:0006466)2.99304654
7Renal duplication (HP:0000075)2.87793773
8Abnormality of the 4th metacarpal (HP:0010012)2.76502416
9Atrophic scars (HP:0001075)2.72969337
10Cerebral aneurysm (HP:0004944)2.67354678
11Bladder diverticulum (HP:0000015)2.66003851
12Broad metatarsal (HP:0001783)2.58633638
13Coronal craniosynostosis (HP:0004440)2.57796044
14Wrist flexion contracture (HP:0001239)2.40222309
15Hepatoblastoma (HP:0002884)2.40094117
16Morphological abnormality of the middle ear (HP:0008609)2.39646615
17Cervical subluxation (HP:0003308)2.38630185
18Broad thumb (HP:0011304)2.31709752
19Neonatal short-limb short stature (HP:0008921)2.29803804
20Deviation of the hallux (HP:0010051)2.26583505
21Bowel diverticulosis (HP:0005222)2.25006185
22Genu recurvatum (HP:0002816)2.19431126
23Selective tooth agenesis (HP:0001592)2.19278802
24Abnormality of dentin (HP:0010299)2.14810788
25Aortic dissection (HP:0002647)2.11269984
26Hallux valgus (HP:0001822)2.10963436
27Turricephaly (HP:0000262)2.10589595
28Abnormality of the distal phalanx of the thumb (HP:0009617)2.07938321
29Broad face (HP:0000283)2.07578831
30Arterial tortuosity (HP:0005116)2.06870578
31Broad long bones (HP:0005622)2.04572389
32Mitral valve prolapse (HP:0001634)2.04370845
33Overgrowth (HP:0001548)2.04127448
34Hyperacusis (HP:0010780)2.03044090
35Vascular tortuosity (HP:0004948)2.02999527
36Buphthalmos (HP:0000557)2.02408985
37Abnormality of the astrocytes (HP:0100707)2.01970587
38Astrocytoma (HP:0009592)2.01970587
39Fragile skin (HP:0001030)1.99474474
40Right ventricular cardiomyopathy (HP:0011663)1.99435942
41Pterygium (HP:0001059)1.99199310
42Dilatation of the ascending aorta (HP:0005111)1.97232856
43Advanced eruption of teeth (HP:0006288)1.96776691
44Spinal rigidity (HP:0003306)1.94146595
45Trigonocephaly (HP:0000243)1.93140441
46Lymphangioma (HP:0100764)1.92918676
47Natal tooth (HP:0000695)1.92296926
48Aortic aneurysm (HP:0004942)1.92284152
49Bronchomalacia (HP:0002780)1.92010231
50Broad phalanges of the hand (HP:0009768)1.91913586
51Vertebral arch anomaly (HP:0008438)1.90540231
52Mesomelia (HP:0003027)1.89805257
53Wide anterior fontanel (HP:0000260)1.88729701
54Broad phalanx (HP:0006009)1.88426237
55Broad toe (HP:0001837)1.87465742
56Broad finger (HP:0001500)1.87335073
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85253313
58Abnormality of the dental root (HP:0006486)1.85167247
59Taurodontia (HP:0000679)1.85167247
60Abnormality of permanent molar morphology (HP:0011071)1.85167247
61Soft skin (HP:0000977)1.84725246
62Abnormality of molar morphology (HP:0011070)1.84433091
63Abnormality of molar (HP:0011077)1.84433091
64Flat cornea (HP:0007720)1.83250362
65Shawl scrotum (HP:0000049)1.81197660
66Short 5th finger (HP:0009237)1.80847869
67Increased connective tissue (HP:0009025)1.80388010
68Ulnar bowing (HP:0003031)1.79931323
69Blue sclerae (HP:0000592)1.79239742
70Renovascular hypertension (HP:0100817)1.78174311
71Obstructive sleep apnea (HP:0002870)1.77800819
72Increased nuchal translucency (HP:0010880)1.77655910
73High anterior hairline (HP:0009890)1.77450938
74Wormian bones (HP:0002645)1.77338700
75Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77040594
76Laryngomalacia (HP:0001601)1.75799124
77Short nail (HP:0001799)1.75726663
78Mildly elevated creatine phosphokinase (HP:0008180)1.75313656
79Aneurysm (HP:0002617)1.73289609
80Hyperextensible skin (HP:0000974)1.71882471
81Arnold-Chiari malformation (HP:0002308)1.71516719
82Cutaneous syndactyly (HP:0012725)1.71133023
83Tibial bowing (HP:0002982)1.71063727
84Neoplasm of the heart (HP:0100544)1.70554116
85Absent eyelashes (HP:0000561)1.69289077
86Short humerus (HP:0005792)1.68690429
87Insomnia (HP:0100785)1.68664554
88Asymmetry of the thorax (HP:0001555)1.68594484
89Follicular hyperkeratosis (HP:0007502)1.68241335
90Urethral obstruction (HP:0000796)1.67963673
91Elfin facies (HP:0004428)1.66535847
92Abnormality of the diencephalon (HP:0010662)1.65788577
93Macroorchidism (HP:0000053)1.65247173
94Preaxial foot polydactyly (HP:0001841)1.65238241
95Sparse lateral eyebrow (HP:0005338)1.64504389
96Enlarged penis (HP:0000040)1.64441024
97Aplasia involving bones of the upper limbs (HP:0009823)1.62946474
98Aplasia of the phalanges of the hand (HP:0009802)1.62946474
99Aplasia involving bones of the extremities (HP:0009825)1.62946474
100Overriding aorta (HP:0002623)1.62748315
101Short phalanx of the thumb (HP:0009660)1.62116798
102Cutaneous finger syndactyly (HP:0010554)1.61698931
103Missing ribs (HP:0000921)1.61624164
104Congenital glaucoma (HP:0001087)1.61187684
105Abnormality of the aortic arch (HP:0012303)1.61064513
106Partial duplication of thumb phalanx (HP:0009944)1.59601743
107Rectal prolapse (HP:0002035)1.59104794
108Abnormality of the nasal septum (HP:0000419)1.58991536
109Fragile nails (HP:0001808)1.58888710
110Short 1st metacarpal (HP:0010034)1.58388808
111Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.58388808
112Abnormality of the dental pulp (HP:0006479)1.58171195
113Partial duplication of the phalanx of hand (HP:0009999)1.57687145
114Germ cell neoplasia (HP:0100728)1.57611458
115Joint laxity (HP:0001388)1.57134784
116Upper limb amyotrophy (HP:0009129)1.57060038
117Distal upper limb amyotrophy (HP:0007149)1.57060038
118Ependymoma (HP:0002888)1.56840796
119Ankyloglossia (HP:0010296)1.56587286
120Patellar dislocation (HP:0002999)1.56333269
121Heterotopia (HP:0002282)1.55959015
122Alopecia of scalp (HP:0002293)1.55172744
123Precocious puberty (HP:0000826)1.54646765
124Flat acetabular roof (HP:0003180)1.54572894
125Glioma (HP:0009733)1.53776695
126Hypoplastic labia majora (HP:0000059)1.53368854
127Deviation of the thumb (HP:0009603)1.52722031
128Bell-shaped thorax (HP:0001591)1.52706348
129Broad hallux (HP:0010055)1.52312692
130Lip pit (HP:0100267)1.52215050
131Bilateral microphthalmos (HP:0007633)1.52145015
132Rib fusion (HP:0000902)1.52120859
133Hypoplastic ischia (HP:0003175)1.51959386
134Radial bowing (HP:0002986)1.51849187
135Tracheal stenosis (HP:0002777)1.51739008
136Midline defect of the nose (HP:0004122)1.50798775
137Abnormality of the phalanges of the hallux (HP:0010057)1.50574917
138Syringomyelia (HP:0003396)1.50272596
139Spinal cord lesions (HP:0100561)1.50272596
140Hypoplasia of dental enamel (HP:0006297)1.47811394
141Limited elbow extension (HP:0001377)1.46146512
142Midface retrusion (HP:0011800)1.44992184
143Septate vagina (HP:0001153)1.44128261
144Bowed forearm bones (HP:0003956)1.42051609
145Bowing of the arm (HP:0006488)1.42051609
146Abnormality of the lacrimal duct (HP:0011481)1.41071797
147Mitral regurgitation (HP:0001653)1.40789176
148Abnormality of nail color (HP:0100643)1.39654765
149Abnormality of the distal phalanges of the toes (HP:0010182)1.39336735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.84163675
2DDR23.58579687
3LATS23.49621409
4CDK123.19945636
5TRIB33.05018507
6PDGFRA2.92146593
7MST1R2.36069232
8EPHB22.25335687
9PRKD32.07787239
10ICK1.95935923
11TTN1.95785839
12PKN21.86418260
13EPHA21.85551631
14RIPK11.84042402
15CASK1.79662036
16TYRO31.78005447
17SIK11.70348941
18PTK21.68258418
19EEF2K1.59760120
20BMX1.54553717
21MAP3K101.54067048
22FER1.48268283
23* MTOR1.41527744
24PAK21.41348854
25PAK31.37458563
26PNCK1.35816854
27TNIK1.34200969
28FGFR11.32396121
29PAK61.31295020
30PTK61.30818058
31SMG11.29581821
32PAK41.23429719
33BCR1.16781521
34DMPK1.16398694
35MET1.15526027
36STK31.12779045
37NEK11.06298319
38STK38L1.05182255
39MARK11.05047835
40ALK1.03909125
41MAPKAPK31.03540308
42PDGFRB1.03378717
43MAP3K91.01995391
44CAMK1G1.00579094
45STK380.98915095
46NTRK10.97921563
47AKT30.97832688
48CAMK1D0.94857646
49ERBB20.92687085
50ERBB40.91889973
51BRD40.89758219
52CDK60.89728436
53CDC42BPA0.88726123
54KSR10.87638452
55ERBB30.86234846
56EPHA30.86135002
57ERN10.83225068
58MUSK0.81712065
59EPHB10.80292019
60LMTK20.78965929
61FGFR20.78405015
62SCYL20.76272356
63ROCK10.75700311
64RPS6KB20.75322427
65TAOK10.70736580
66TTK0.70052501
67RET0.69578323
68MAP3K40.68631173
69FGFR40.64929267
70KSR20.64560531
71MAP2K20.63584775
72AKT20.63149513
73LRRK20.62209183
74CDK70.62164774
75WNK10.62058685
76NEK20.61893053
77LIMK10.58402285
78NTRK20.58007272
79NME10.57489246
80PRKCI0.57282020
81PRKD20.56654688
82STK390.55659016
83MAPK150.54525586
84TESK10.54290655
85CDC70.53842838
86PHKG10.53008356
87PHKG20.53008356
88ILK0.52077136
89MARK20.51863355
90MAP2K10.51833664
91CDK150.51733509
92SGK4940.51089378
93SGK2230.51089378
94SGK30.50627575
95ROCK20.50537435
96CSNK1E0.49936648
97CDK140.49118280
98CDK180.48358926
99UHMK10.47488445
100CHEK20.47472559
101DYRK1B0.47259849
102WNK40.47228009
103CHEK10.47142565
104NEK60.46030846
105TSSK60.45938780
106TGFBR10.44278036
107CDK20.44123436
108CDK11A0.43930045
109PRKAA10.43267291
110CSNK1A1L0.43018707
111MINK10.42820149
112MKNK10.42452118
113RPS6KA20.40321698
114RPS6KB10.39899862
115DYRK20.39814020
116MAP3K20.38988985
117CAMK2B0.38980467
118MKNK20.38614249
119PRKCZ0.38451566
120PRKD10.38422522
121MYLK0.38338164
122MAPK90.37470487
123PLK30.37349455
124MAP3K80.37240380
125SIK20.37191542
126GSK3B0.37129210
127MAP3K70.37114682
128MAP3K60.36608519
129SGK20.36242277
130CDK10.36221085
131CAMK2G0.35815626
132MAPK80.34169256
133WEE10.34130747
134CAMK2D0.34039967
135RPS6KL10.32549045
136RPS6KC10.32549045
137RPS6KA10.32246983

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.87163886
2Hippo signaling pathway_Homo sapiens_hsa043902.72006895
3Hedgehog signaling pathway_Homo sapiens_hsa043402.51784243
4ECM-receptor interaction_Homo sapiens_hsa045122.34560551
5Adherens junction_Homo sapiens_hsa045202.34139853
6Focal adhesion_Homo sapiens_hsa045102.04116282
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.03592044
8Proteoglycans in cancer_Homo sapiens_hsa052051.98768349
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95189596
10Bladder cancer_Homo sapiens_hsa052191.83870746
11MicroRNAs in cancer_Homo sapiens_hsa052061.78141407
12TGF-beta signaling pathway_Homo sapiens_hsa043501.75800995
13Wnt signaling pathway_Homo sapiens_hsa043101.74951846
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72786042
15Axon guidance_Homo sapiens_hsa043601.67414193
16Tight junction_Homo sapiens_hsa045301.66238131
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.59455091
18Endometrial cancer_Homo sapiens_hsa052131.55305366
19Small cell lung cancer_Homo sapiens_hsa052221.48068855
20Vitamin B6 metabolism_Homo sapiens_hsa007501.46801513
21mTOR signaling pathway_Homo sapiens_hsa041501.46546953
22Melanogenesis_Homo sapiens_hsa049161.45628667
23Colorectal cancer_Homo sapiens_hsa052101.44183242
24Dilated cardiomyopathy_Homo sapiens_hsa054141.42291818
25Glioma_Homo sapiens_hsa052141.36675618
26Chronic myeloid leukemia_Homo sapiens_hsa052201.35363348
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32512396
28Protein digestion and absorption_Homo sapiens_hsa049741.32177940
29Notch signaling pathway_Homo sapiens_hsa043301.30716102
30Steroid biosynthesis_Homo sapiens_hsa001001.30053218
31Melanoma_Homo sapiens_hsa052181.26707944
32Gap junction_Homo sapiens_hsa045401.26050831
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24523437
34Pathways in cancer_Homo sapiens_hsa052001.22294524
35Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16067338
36Amoebiasis_Homo sapiens_hsa051461.15768748
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14944897
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13967450
39Estrogen signaling pathway_Homo sapiens_hsa049151.13465253
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13440173
41Rap1 signaling pathway_Homo sapiens_hsa040151.12486233
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11532884
43Renal cell carcinoma_Homo sapiens_hsa052111.10128747
44Prostate cancer_Homo sapiens_hsa052151.09522631
45Dorso-ventral axis formation_Homo sapiens_hsa043201.09501005
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08154223
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.07311377
48ErbB signaling pathway_Homo sapiens_hsa040121.05983883
49GnRH signaling pathway_Homo sapiens_hsa049121.05755279
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04143029
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03383488
52Thyroid cancer_Homo sapiens_hsa052161.02403676
53Cell cycle_Homo sapiens_hsa041100.99874564
54Pancreatic cancer_Homo sapiens_hsa052120.99138710
55Lysine degradation_Homo sapiens_hsa003100.98334617
56mRNA surveillance pathway_Homo sapiens_hsa030150.98135078
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96992998
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96439277
59p53 signaling pathway_Homo sapiens_hsa041150.95717338
60Oocyte meiosis_Homo sapiens_hsa041140.93274908
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91785333
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89685673
63HTLV-I infection_Homo sapiens_hsa051660.89056451
64Viral myocarditis_Homo sapiens_hsa054160.88550204
65Non-small cell lung cancer_Homo sapiens_hsa052230.84177751
66VEGF signaling pathway_Homo sapiens_hsa043700.79790124
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.79567847
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79536780
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77786406
70AMPK signaling pathway_Homo sapiens_hsa041520.77221160
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74256977
72Circadian rhythm_Homo sapiens_hsa047100.74178167
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73454209
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73109798
75Choline metabolism in cancer_Homo sapiens_hsa052310.71883057
76Fatty acid biosynthesis_Homo sapiens_hsa000610.71870494
77RNA transport_Homo sapiens_hsa030130.70367180
78MAPK signaling pathway_Homo sapiens_hsa040100.68329492
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68188069
80Insulin signaling pathway_Homo sapiens_hsa049100.68161528
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66555863
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66551694
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66523253
84Insulin secretion_Homo sapiens_hsa049110.65560227
85Ovarian steroidogenesis_Homo sapiens_hsa049130.65413701
86Thyroid hormone synthesis_Homo sapiens_hsa049180.65346135
87Ras signaling pathway_Homo sapiens_hsa040140.65243319
88Type II diabetes mellitus_Homo sapiens_hsa049300.64447887
89FoxO signaling pathway_Homo sapiens_hsa040680.63128408
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62815401
91Gastric acid secretion_Homo sapiens_hsa049710.62520950
92Oxytocin signaling pathway_Homo sapiens_hsa049210.62408646
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61706547
94Glutamatergic synapse_Homo sapiens_hsa047240.61278787
95Cocaine addiction_Homo sapiens_hsa050300.60290019
96Long-term potentiation_Homo sapiens_hsa047200.59127136
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.58523439
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58502973
99Inositol phosphate metabolism_Homo sapiens_hsa005620.58002188
100Dopaminergic synapse_Homo sapiens_hsa047280.57709343
101Endocytosis_Homo sapiens_hsa041440.57495003
102Glucagon signaling pathway_Homo sapiens_hsa049220.57265196
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56295336
104Long-term depression_Homo sapiens_hsa047300.54949481
105Insulin resistance_Homo sapiens_hsa049310.54621519
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53971614
107N-Glycan biosynthesis_Homo sapiens_hsa005100.53614400
108Nitrogen metabolism_Homo sapiens_hsa009100.53580825
109cAMP signaling pathway_Homo sapiens_hsa040240.52968351
110Sphingolipid metabolism_Homo sapiens_hsa006000.52754304
111Vibrio cholerae infection_Homo sapiens_hsa051100.52263795
112Cholinergic synapse_Homo sapiens_hsa047250.49752288
113Histidine metabolism_Homo sapiens_hsa003400.48502679
114Prolactin signaling pathway_Homo sapiens_hsa049170.48152332
115Circadian entrainment_Homo sapiens_hsa047130.48018084
116HIF-1 signaling pathway_Homo sapiens_hsa040660.47069594
117Bile secretion_Homo sapiens_hsa049760.46531963
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46236891
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.46235342
120Fatty acid metabolism_Homo sapiens_hsa012120.44911111

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