DLEU7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.43247318
2vocalization behavior (GO:0071625)5.19681387
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.10222104
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.10222104
5modulation by symbiont of host immune response (GO:0052553)5.10222104
6positive regulation by symbiont of host defense response (GO:0052509)5.10222104
7modulation by symbiont of host defense response (GO:0052031)5.10222104
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.10222104
9synaptic vesicle exocytosis (GO:0016079)5.07965776
10neutrophil activation involved in immune response (GO:0002283)5.05629688
11neurotransmitter catabolic process (GO:0042135)4.90101412
12detection of other organism (GO:0098543)4.70625441
13negative regulation of interleukin-12 production (GO:0032695)4.69976926
14microglial cell activation (GO:0001774)4.61762338
15macrophage activation involved in immune response (GO:0002281)4.61679469
16granulocyte activation (GO:0036230)4.58914597
17response to peptidoglycan (GO:0032494)4.54582692
18neuron recognition (GO:0008038)4.53693237
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40096200
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38655575
21detection of molecule of bacterial origin (GO:0032490)4.35577300
22neurotransmitter secretion (GO:0007269)4.34225691
23detection of bacterium (GO:0016045)4.32951014
24immunoglobulin mediated immune response (GO:0016064)4.32801702
25positive regulation of toll-like receptor signaling pathway (GO:0034123)4.31959719
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.24665741
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24080667
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.23060672
29detection of external biotic stimulus (GO:0098581)4.20978527
30respiratory burst (GO:0045730)4.12364827
31neutrophil activation (GO:0042119)4.10778171
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08322687
33neurotransmitter biosynthetic process (GO:0042136)4.07150876
34proline transport (GO:0015824)4.06083679
35protein localization to synapse (GO:0035418)4.02682213
36positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.98238526
37energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.98213515
38ATP hydrolysis coupled proton transport (GO:0015991)3.98213515
39glutamate receptor signaling pathway (GO:0007215)3.98087747
40presynaptic membrane organization (GO:0097090)3.97062805
41mating behavior (GO:0007617)3.95001513
42cellular extravasation (GO:0045123)3.93329922
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92644576
44ATP synthesis coupled proton transport (GO:0015986)3.92644576
45glutamate secretion (GO:0014047)3.89405285
46regulation of glutamate receptor signaling pathway (GO:1900449)3.88257304
47detection of biotic stimulus (GO:0009595)3.86711280
48neuronal action potential propagation (GO:0019227)3.86673799
49neurotransmitter transport (GO:0006836)3.85701422
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.84419656
51regulation of helicase activity (GO:0051095)3.84224440
52succinate metabolic process (GO:0006105)3.84151364
53myeloid cell activation involved in immune response (GO:0002275)3.84010546
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.81384499
55oxygen transport (GO:0015671)3.81326840
56neuron-neuron synaptic transmission (GO:0007270)3.80576164
57positive regulation of gamma-delta T cell activation (GO:0046645)3.76092390
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.75470860
59B cell mediated immunity (GO:0019724)3.75296579
60regulation of interferon-beta biosynthetic process (GO:0045357)3.74421514
61positive regulation of mast cell activation (GO:0033005)3.73514304
62regulation of neurotransmitter levels (GO:0001505)3.71527433
63histone H3-K9 demethylation (GO:0033169)3.70498168
64axonal fasciculation (GO:0007413)3.64516773
65positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62730556
66gamma-aminobutyric acid transport (GO:0015812)3.62463600
67neurotransmitter metabolic process (GO:0042133)3.62024714
68dopamine biosynthetic process (GO:0042416)3.61769599
69positive regulation of synapse assembly (GO:0051965)3.61490298
70regulation of synaptic vesicle exocytosis (GO:2000300)3.59709726
71positive regulation of mast cell activation involved in immune response (GO:0033008)3.58943293
72positive regulation of mast cell degranulation (GO:0043306)3.58943293
73catecholamine transport (GO:0051937)3.58115468
74layer formation in cerebral cortex (GO:0021819)3.55256269
75negative regulation of cell killing (GO:0031342)3.54330720
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54330720
77synaptic transmission, glutamatergic (GO:0035249)3.53886445
78neutrophil mediated immunity (GO:0002446)3.53296360
79regulation of T-helper 1 cell differentiation (GO:0045625)3.52483920
80myeloid leukocyte mediated immunity (GO:0002444)3.52071338
81synaptic vesicle maturation (GO:0016188)3.51296806
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51062895
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.49253674
84presynaptic membrane assembly (GO:0097105)3.47800874
85regulation of double-strand break repair via homologous recombination (GO:0010569)3.44916976
86transmission of nerve impulse (GO:0019226)3.44800873
87macrophage activation (GO:0042116)3.43817177
88oligosaccharide catabolic process (GO:0009313)3.40342692
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38626117
90response to host immune response (GO:0052572)3.38626117
91transferrin transport (GO:0033572)3.36460673
92regulation of protein kinase A signaling (GO:0010738)3.35995906
93regulation of macrophage chemotaxis (GO:0010758)3.33853234
94response to histamine (GO:0034776)3.32909856
95respiratory electron transport chain (GO:0022904)3.32747825
96dopamine transport (GO:0015872)3.30334694
97natural killer cell differentiation (GO:0001779)3.29954328
98exploration behavior (GO:0035640)3.28545350
99electron transport chain (GO:0022900)3.27078511
100synaptic transmission, dopaminergic (GO:0001963)3.26768869
101regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25976367
102regulation of long-term neuronal synaptic plasticity (GO:0048169)3.25805728
103locomotory exploration behavior (GO:0035641)3.23602861
104catecholamine biosynthetic process (GO:0042423)3.23166235
105catechol-containing compound biosynthetic process (GO:0009713)3.23166235
106antigen processing and presentation via MHC class Ib (GO:0002475)3.22774977
107synaptic transmission, cholinergic (GO:0007271)3.22379328
108regulation of mast cell degranulation (GO:0043304)3.21450855
109trivalent inorganic cation transport (GO:0072512)3.16462376
110ferric iron transport (GO:0015682)3.16462376
111regulation of excitatory postsynaptic membrane potential (GO:0060079)3.14565695
112positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14457478
113cellular response to ammonium ion (GO:0071242)3.14308352
114superoxide anion generation (GO:0042554)3.09715747
115regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08898513
116leukocyte migration involved in inflammatory response (GO:0002523)3.07648914
117dendrite development (GO:0016358)3.05220859
118regulation of synapse structural plasticity (GO:0051823)3.04626842
119regulation of synaptic vesicle transport (GO:1902803)3.03552388
120startle response (GO:0001964)3.02843694
121regulation of postsynaptic membrane potential (GO:0060078)3.01811911
122glycosphingolipid catabolic process (GO:0046479)3.00846838
123negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.99435328
124regulation of mast cell activation (GO:0033003)2.98515774
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95124628
126neuromuscular process controlling posture (GO:0050884)2.94860164
127negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.94845208
128phagocytosis, engulfment (GO:0006911)2.94652799
129positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.94055781
130regulation of glutamate secretion (GO:0014048)2.94051255
131G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93291965
132imidazole-containing compound metabolic process (GO:0052803)2.92939338
133neurotransmitter uptake (GO:0001504)2.92439148
134regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92156688
135dendritic spine morphogenesis (GO:0060997)2.91780031
136regulation of mast cell activation involved in immune response (GO:0033006)2.91514475
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.91417491
138leukocyte degranulation (GO:0043299)2.90174929
139cellular response to ethanol (GO:0071361)2.90064780
140striatum development (GO:0021756)2.88897050
141regulation of hypersensitivity (GO:0002883)2.86766947
142synaptic transmission (GO:0007268)2.86567408
143regulation of neuronal synaptic plasticity (GO:0048168)2.84724125
144detection of calcium ion (GO:0005513)2.84405183
145negative regulation of microtubule polymerization (GO:0031115)2.83311046
146response to cocaine (GO:0042220)2.83164696
147regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.83135963
148synapse assembly (GO:0007416)2.82877613
149cytokine secretion (GO:0050663)2.82405698
150regulation of catecholamine metabolic process (GO:0042069)2.81981234
151regulation of dopamine metabolic process (GO:0042053)2.81981234
152social behavior (GO:0035176)2.81897283
153intraspecies interaction between organisms (GO:0051703)2.81897283
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80767287
155T-helper 1 type immune response (GO:0042088)2.80002377
156regulation of B cell receptor signaling pathway (GO:0050855)2.78745591
157auditory behavior (GO:0031223)2.78191444
158negative regulation of interleukin-1 beta production (GO:0032691)2.77468939
159learning (GO:0007612)2.76961427
160hydrogen ion transmembrane transport (GO:1902600)2.76214545
161phagosome maturation (GO:0090382)2.76000380
162negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75832637
163regulation of mononuclear cell migration (GO:0071675)2.75240227
164membrane hyperpolarization (GO:0060081)2.74867290
165negative regulation of interleukin-10 production (GO:0032693)2.74326309
166positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73521190
167negative regulation of DNA recombination (GO:0045910)2.73035587
168response to host (GO:0075136)2.70422350
169response to host defenses (GO:0052200)2.70422350
170response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.70422350
171regulation of gamma-delta T cell activation (GO:0046643)2.70241369
172hydrogen peroxide biosynthetic process (GO:0050665)2.69254199
173neutrophil chemotaxis (GO:0030593)2.68784631
174interferon-gamma-mediated signaling pathway (GO:0060333)2.68504159
175positive regulation of antigen processing and presentation (GO:0002579)2.67649020
176regulation of toll-like receptor signaling pathway (GO:0034121)2.66362993
177proteasome assembly (GO:0043248)2.66175290
178production of molecular mediator involved in inflammatory response (GO:0002532)2.64764524
179mitotic G2/M transition checkpoint (GO:0044818)2.64251222
180glycolipid catabolic process (GO:0019377)2.63389629
181myeloid leukocyte activation (GO:0002274)2.62487095
182retinal cone cell development (GO:0046549)2.62065995
183neutrophil migration (GO:1990266)2.61559577
184negative regulation of T cell mediated immunity (GO:0002710)2.58052114
185membrane invagination (GO:0010324)2.57816094
186mitotic G2 DNA damage checkpoint (GO:0007095)2.56330547
187DNA strand elongation (GO:0022616)2.56153696
188regulation of exit from mitosis (GO:0007096)2.56141476
189N-terminal protein amino acid acetylation (GO:0006474)2.55631902
190I-kappaB phosphorylation (GO:0007252)2.55412691
191positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.54641268
192purine-containing compound salvage (GO:0043101)2.54258289
193positive regulation of cellular amide metabolic process (GO:0034250)2.53773340
194chromatin remodeling at centromere (GO:0031055)2.52476946
195regulation of leukocyte degranulation (GO:0043300)2.52469891
196CENP-A containing nucleosome assembly (GO:0034080)2.50437870
197regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.49925842
198regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.48126969
199negative regulation of interleukin-1 production (GO:0032692)2.47411285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03235295
2EZH2_22144423_ChIP-Seq_EOC_Human5.99919559
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.47637962
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.28162490
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.43470281
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.41823585
7GBX2_23144817_ChIP-Seq_PC3_Human3.38408116
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.22317145
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.13723347
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.13359024
11TAF15_26573619_Chip-Seq_HEK293_Human3.10570216
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.97611414
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.89045433
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.87222201
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.85878405
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.85620141
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84486601
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80696976
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80696976
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79228570
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.72243537
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66680937
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65943116
24REST_21632747_ChIP-Seq_MESCs_Mouse2.56692583
25IGF1R_20145208_ChIP-Seq_DFB_Human2.56307746
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.53253939
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47704243
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39274342
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36871227
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35196639
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33149870
32VDR_22108803_ChIP-Seq_LS180_Human2.32361664
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.32311674
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.31147539
35CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29943950
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24786768
37IRF8_22096565_ChIP-ChIP_GC-B_Human2.22760264
38EST1_17652178_ChIP-ChIP_JURKAT_Human2.18610674
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17641653
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15250499
41SPI1_23547873_ChIP-Seq_NB4_Human2.13985408
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13243629
43IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12649795
44* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08688307
45AR_21572438_ChIP-Seq_LNCaP_Human2.07794496
46RNF2_27304074_Chip-Seq_ESCs_Mouse2.06754279
47EZH2_27294783_Chip-Seq_ESCs_Mouse2.03846427
48* VDR_24787735_ChIP-Seq_THP-1_Human2.03600433
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95004948
50GATA1_22025678_ChIP-Seq_K562_Human1.94364712
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.91485890
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89759184
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89405065
54ZNF274_21170338_ChIP-Seq_K562_Hela1.87138133
55P300_19829295_ChIP-Seq_ESCs_Human1.82308851
56FUS_26573619_Chip-Seq_HEK293_Human1.82097998
57DROSHA_22980978_ChIP-Seq_HELA_Human1.82039188
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80162721
59SPI1_23127762_ChIP-Seq_K562_Human1.72260892
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.71343473
61SMAD4_21799915_ChIP-Seq_A2780_Human1.69500416
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68630494
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.68536625
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67406938
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65409587
66RNF2_27304074_Chip-Seq_NSC_Mouse1.64967261
67SCL_19346495_ChIP-Seq_HPC-7_Human1.64134091
68PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63836298
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.63350581
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60579939
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58990093
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57783578
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.55661014
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54530894
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54147154
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53369712
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51043384
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50232369
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49420524
80* VDR_24763502_ChIP-Seq_THP-1_Human1.47907331
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.46926305
82ER_23166858_ChIP-Seq_MCF-7_Human1.44264603
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41501961
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.39920286
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37358054
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36890702
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36066711
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36051281
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35570441
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.35445672
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35440494
92IRF1_19129219_ChIP-ChIP_H3396_Human1.35426621
93* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33832548
94AR_25329375_ChIP-Seq_VCAP_Human1.31967700
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31368523
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.31168668
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29490656
98BCAT_22108803_ChIP-Seq_LS180_Human1.28421143
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26008927
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.25957879
101VDR_23849224_ChIP-Seq_CD4+_Human1.25806011
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25338790
103* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23611611
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23289221
105GATA3_26560356_Chip-Seq_TH2_Human1.23153318
106* JUN_21703547_ChIP-Seq_K562_Human1.21583087
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21299915
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19912492
109RUNX_20019798_ChIP-Seq_JUKART_Human1.19456094
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.16792525
111CBP_20019798_ChIP-Seq_JUKART_Human1.16547264
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16547264
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15102207
114* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15004007
115FOXP3_21729870_ChIP-Seq_TREG_Human1.14613274
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12484166
117MYB_26560356_Chip-Seq_TH2_Human1.12051104
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.11635268
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11142016
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10800771
121* PRDM14_20953172_ChIP-Seq_ESCs_Human1.08701616
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08111287
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07405553
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.05582944
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04891674
126TP53_18474530_ChIP-ChIP_U2OS_Human1.04369099
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02585750
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01330238
129STAT3_23295773_ChIP-Seq_U87_Human1.00200336
130CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00143531
131GATA3_26560356_Chip-Seq_TH1_Human0.98289516
132MYB_26560356_Chip-Seq_TH1_Human0.97952842
133TCF4_23295773_ChIP-Seq_U87_Human0.97764954
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97182797
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96256747
136CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95791219
137* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95702824
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95400246
139SPI1_20517297_ChIP-Seq_HL60_Human0.95205639
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94754165
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94649587
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94649587
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94649587
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94616684
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94448778
146SALL4_22934838_ChIP-ChIP_CD34+_Human0.94298800
147CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94261397
148PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94151105
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93693056
150AR_21909140_ChIP-Seq_LNCAP_Human0.93492437
151KDM2B_26808549_Chip-Seq_REH_Human0.93300361
152* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93089778
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.92039872
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91975282
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.91657655
156* PU_27001747_Chip-Seq_BMDM_Mouse0.91204304
157DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90824972
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90528431
159YY1_21170310_ChIP-Seq_MESCs_Mouse0.89962808
160NFE2_27457419_Chip-Seq_LIVER_Mouse0.89715593
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89713595
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89713595
163SMAD_19615063_ChIP-ChIP_OVARY_Human0.88803064
164RUNX1_22412390_ChIP-Seq_EML_Mouse0.88726753
165CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88396795
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87314782
167HTT_18923047_ChIP-ChIP_STHdh_Human0.86984257
168E2F1_21310950_ChIP-Seq_MCF-7_Human0.86868444
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86659419
170TP53_20018659_ChIP-ChIP_R1E_Mouse0.86612954
171EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86481385
172PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86208735
173* SMRT_27268052_Chip-Seq_Bcells_Human0.85365825
174EWS_26573619_Chip-Seq_HEK293_Human0.84446175
175* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83485534
176AR_19668381_ChIP-Seq_PC3_Human0.82773770
177FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80867941
178GATA3_27048872_Chip-Seq_THYMUS_Human0.78534709
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77597448
180LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76516044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.67761912
2MP0003880_abnormal_central_pattern4.61845291
3MP0004859_abnormal_synaptic_plasticity3.89212341
4MP0002876_abnormal_thyroid_physiology3.68855734
5MP0006276_abnormal_autonomic_nervous3.52376443
6MP0003635_abnormal_synaptic_transmissio3.47944157
7MP0009046_muscle_twitch3.39330038
8MP0009745_abnormal_behavioral_response3.33534413
9MP0002064_seizures3.14614182
10MP0001501_abnormal_sleep_pattern2.98948543
11MP0002735_abnormal_chemical_nociception2.96336088
12MP0005671_abnormal_response_to2.91381808
13MP0005645_abnormal_hypothalamus_physiol2.86159366
14MP0001835_abnormal_antigen_presentation2.73572243
15MP0002063_abnormal_learning/memory/cond2.73473266
16MP0009840_abnormal_foam_cell2.72752238
17MP0003724_increased_susceptibility_to2.68074428
18MP0003303_peritoneal_inflammation2.67569063
19MP0002272_abnormal_nervous_system2.66541975
20MP0003436_decreased_susceptibility_to2.52884098
21MP0002572_abnormal_emotion/affect_behav2.51932005
22MP0002419_abnormal_innate_immunity2.50744396
23MP0002734_abnormal_mechanical_nocicepti2.49951301
24MP0001968_abnormal_touch/_nociception2.45520725
25MP0002148_abnormal_hypersensitivity_rea2.42133174
26MP0008877_abnormal_DNA_methylation2.41274207
27MP0001529_abnormal_vocalization2.40908068
28MP0002254_reproductive_system_inflammat2.34614300
29MP0002733_abnormal_thermal_nociception2.32624403
30MP0009785_altered_susceptibility_to2.28030882
31MP0004270_analgesia2.27635338
32MP0001905_abnormal_dopamine_level2.23167015
33MP0001486_abnormal_startle_reflex2.17983868
34MP0002822_catalepsy2.11020161
35MP0002736_abnormal_nociception_after2.09253507
36MP0006082_CNS_inflammation2.07888082
37MP0005025_abnormal_response_to2.07561812
38MP0002277_abnormal_respiratory_mucosa2.07392789
39MP0005423_abnormal_somatic_nervous2.01638413
40MP0001970_abnormal_pain_threshold2.01166251
41MP0001440_abnormal_grooming_behavior1.97159135
42MP0003172_abnormal_lysosome_physiology1.96272446
43MP0002452_abnormal_antigen_presenting1.95928875
44MP0005000_abnormal_immune_tolerance1.94686268
45MP0005387_immune_system_phenotype1.92438986
46MP0001790_abnormal_immune_system1.92438986
47MP0010094_abnormal_chromosome_stability1.86594908
48MP0001800_abnormal_humoral_immune1.86539552
49MP0003879_abnormal_hair_cell1.86234776
50MP0001348_abnormal_lacrimal_gland1.85936560
51MP0002067_abnormal_sensory_capabilities1.85762880
52MP0002184_abnormal_innervation1.82435070
53MP0002723_abnormal_immune_serum1.79449981
54MP0009764_decreased_sensitivity_to1.79293388
55MP0008260_abnormal_autophagy1.75494399
56MP0003122_maternal_imprinting1.73806076
57MP0001819_abnormal_immune_cell1.73569128
58MP0002420_abnormal_adaptive_immunity1.73531411
59MP0000778_abnormal_nervous_system1.71097298
60MP0002909_abnormal_adrenal_gland1.68212964
61MP0008872_abnormal_physiological_respon1.66589620
62MP0005058_abnormal_lysosome_morphology1.65188509
63MP0002557_abnormal_social/conspecific_i1.64602928
64MP0004142_abnormal_muscle_tone1.64499640
65MP0005174_abnormal_tail_pigmentation1.62307798
66MP0009278_abnormal_bone_marrow1.61240172
67MP0005464_abnormal_platelet_physiology1.60215889
68MP0000604_amyloidosis1.59374729
69MP0010386_abnormal_urinary_bladder1.54859448
70MP0000015_abnormal_ear_pigmentation1.54714110
71MP0003690_abnormal_glial_cell1.53522006
72MP0003300_gastrointestinal_ulcer1.51993370
73MP0003011_delayed_dark_adaptation1.51971067
74MP0002638_abnormal_pupillary_reflex1.51405916
75MP0004924_abnormal_behavior1.46842832
76MP0005386_behavior/neurological_phenoty1.46842832
77MP0004742_abnormal_vestibular_system1.45282726
78MP0001188_hyperpigmentation1.44799516
79MP0002405_respiratory_system_inflammati1.38721512
80MP0008569_lethality_at_weaning1.38240979
81MP0005646_abnormal_pituitary_gland1.36937478
82MP0002066_abnormal_motor_capabilities/c1.34002208
83MP0002837_dystrophic_cardiac_calcinosis1.31203117
84MP0002009_preneoplasia1.30530327
85MP0006292_abnormal_olfactory_placode1.29589824
86MP0001346_abnormal_lacrimal_gland1.28379773
87MP0000751_myopathy1.27142750
88MP0005535_abnormal_body_temperature1.25278781
89MP0003075_altered_response_to1.24913737
90MP0001502_abnormal_circadian_rhythm1.24634984
91MP0000538_abnormal_urinary_bladder1.24047762
92MP0003329_amyloid_beta_deposits1.23346863
93MP0004811_abnormal_neuron_physiology1.22692691
94MP0010307_abnormal_tumor_latency1.21976080
95MP0001845_abnormal_inflammatory_respons1.21219226
96MP0000716_abnormal_immune_system1.20737983
97MP0000920_abnormal_myelination1.19977285
98MP0005167_abnormal_blood-brain_barrier1.19957976
99MP0008058_abnormal_DNA_repair1.19811138
100MP0002882_abnormal_neuron_morphology1.18415185
101MP0001984_abnormal_olfaction1.18412427
102MP0008874_decreased_physiological_sensi1.18002467
103MP0005075_abnormal_melanosome_morpholog1.16879525
104MP0001533_abnormal_skeleton_physiology1.14889245
105MP0002398_abnormal_bone_marrow1.14222949
106MP0003195_calcinosis1.13537297
107MP0001853_heart_inflammation1.09673597
108MP0003191_abnormal_cellular_cholesterol1.07275890
109MP0005310_abnormal_salivary_gland1.06360502
110MP0000689_abnormal_spleen_morphology1.06038550
111MP0000955_abnormal_spinal_cord1.05751871
112MP0003828_pulmonary_edema1.04026982
113MP0001963_abnormal_hearing_physiology1.03968973
114MP0003787_abnormal_imprinting1.02568685
115MP0002069_abnormal_eating/drinking_beha1.00819409
116MP0008469_abnormal_protein_level1.00802553
117MP0002998_abnormal_bone_remodeling0.99279739
118MP0001664_abnormal_digestion0.97721466
119MP0002102_abnormal_ear_morphology0.95245404
120MP0003448_altered_tumor_morphology0.94200652
121MP0000343_altered_response_to0.94026365
122MP0004510_myositis0.93945947
123MP0008057_abnormal_DNA_replication0.93761546
124MP0006072_abnormal_retinal_apoptosis0.92855260
125MP0004885_abnormal_endolymph0.92234056
126MP0001324_abnormal_eye_pigmentation0.91289400
127MP0004883_abnormal_blood_vessel0.90278574
128MP0002332_abnormal_exercise_endurance0.89650459
129MP0009765_abnormal_xenobiotic_induced0.88752789
130MP0002429_abnormal_blood_cell0.88393174
131MP0002229_neurodegeneration0.88346925
132MP0002722_abnormal_immune_system0.86907734
133MP0003866_abnormal_defecation0.84459871
134MP0002152_abnormal_brain_morphology0.83898652
135MP0002751_abnormal_autonomic_nervous0.83734206
136MP0009333_abnormal_splenocyte_physiolog0.81732748
137MP0002752_abnormal_somatic_nervous0.81701018
138MP0000685_abnormal_immune_system0.80780057
139MP0000631_abnormal_neuroendocrine_gland0.80748360
140MP0009379_abnormal_foot_pigmentation0.80127433
141MP0005551_abnormal_eye_electrophysiolog0.79310767
142MP0000026_abnormal_inner_ear0.78469560
143MP0003137_abnormal_impulse_conducting0.78031560
144MP0003959_abnormal_lean_body0.77730624
145MP0003111_abnormal_nucleus_morphology0.77667632
146MP0001765_abnormal_ion_homeostasis0.76015298
147MP0003638_abnormal_response/metabolism_0.75857130
148MP0002132_abnormal_respiratory_system0.75683218
149MP0009763_increased_sensitivity_to0.74556575
150MP0001485_abnormal_pinna_reflex0.73994639
151MP0001177_atelectasis0.73913158
152MP0002090_abnormal_vision0.71788086
153MP0005397_hematopoietic_system_phenotyp0.70824240
154MP0001545_abnormal_hematopoietic_system0.70824240
155MP0002095_abnormal_skin_pigmentation0.70734586
156MP0005499_abnormal_olfactory_system0.68877302
157MP0005394_taste/olfaction_phenotype0.68877302
158MP0003693_abnormal_embryo_hatching0.67371537
159MP0004085_abnormal_heartbeat0.65356731
160MP0003631_nervous_system_phenotype0.63194576
161MP0004043_abnormal_pH_regulation0.62061406
162MP0001943_abnormal_respiration0.61774527
163MP0003633_abnormal_nervous_system0.61607065
164MP0003938_abnormal_ear_development0.59952658
165MP0004484_altered_response_of0.58385601
166MP0009780_abnormal_chondrocyte_physiolo0.57007689
167MP0000462_abnormal_digestive_system0.56857999
168MP0002163_abnormal_gland_morphology0.56053843
169MP0004215_abnormal_myocardial_fiber0.55558316
170MP0003121_genomic_imprinting0.48920381
171MP0000747_muscle_weakness0.48714545
172MP0000681_abnormal_thyroid_gland0.48457409
173MP0004858_abnormal_nervous_system0.48210183

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.92480084
2Recurrent bacterial skin infections (HP:0005406)4.89090388
3Atonic seizures (HP:0010819)4.76553883
4Focal seizures (HP:0007359)4.69714861
5Myokymia (HP:0002411)4.50427016
6Recurrent abscess formation (HP:0002722)4.48405332
7Limb dystonia (HP:0002451)4.32031591
8Abnormality of macrophages (HP:0004311)4.26530829
9Absence seizures (HP:0002121)4.22376443
10Visual hallucinations (HP:0002367)4.00982475
11Hyperventilation (HP:0002883)3.98818387
12Retrobulbar optic neuritis (HP:0100654)3.90211577
13Optic neuritis (HP:0100653)3.90211577
14Febrile seizures (HP:0002373)3.86102451
15Recurrent gram-negative bacterial infections (HP:0005420)3.82580526
16Stomatitis (HP:0010280)3.80774707
17Systemic lupus erythematosus (HP:0002725)3.79062349
18Eczematoid dermatitis (HP:0000976)3.69157148
19Epileptic encephalopathy (HP:0200134)3.66670029
20Dialeptic seizures (HP:0011146)3.64828744
21Acute necrotizing encephalopathy (HP:0006965)3.54498417
22Mutism (HP:0002300)3.51998596
23Poor suck (HP:0002033)3.46733219
24Orchitis (HP:0100796)3.42420287
25Agnosia (HP:0010524)3.39163138
26Abnormal mitochondria in muscle tissue (HP:0008316)3.37944822
27Increased cerebral lipofuscin (HP:0011813)3.34697542
28Generalized tonic-clonic seizures (HP:0002069)3.28542344
29Abnormality of glycosphingolipid metabolism (HP:0004343)3.24264973
30Abnormality of glycolipid metabolism (HP:0010969)3.24264973
31Abnormality of liposaccharide metabolism (HP:0010968)3.24264973
32Disinhibition (HP:0000734)3.21678528
33Progressive cerebellar ataxia (HP:0002073)3.21177430
34Pheochromocytoma (HP:0002666)3.15615686
35Myositis (HP:0100614)3.13142915
36Progressive macrocephaly (HP:0004481)3.11097189
37Gait imbalance (HP:0002141)3.07712340
38Mitochondrial inheritance (HP:0001427)3.07711657
39Polyphagia (HP:0002591)3.03685023
40Acute encephalopathy (HP:0006846)2.98166654
41Hypothermia (HP:0002045)2.95558814
42Abnormality of calcium-phosphate metabolism (HP:0100530)2.90946389
43Neuroendocrine neoplasm (HP:0100634)2.86909807
44Increased circulating renin level (HP:0000848)2.86016206
45Mediastinal lymphadenopathy (HP:0100721)2.79655596
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.77032992
47Failure to thrive in infancy (HP:0001531)2.76936878
48Abnormal eating behavior (HP:0100738)2.76744148
49Recurrent skin infections (HP:0001581)2.75693193
50Progressive inability to walk (HP:0002505)2.75377531
51Abnormal pupillary function (HP:0007686)2.74135425
52Broad-based gait (HP:0002136)2.71884090
53Abnormality of chromosome stability (HP:0003220)2.70213820
54Congenital primary aphakia (HP:0007707)2.67976361
55Peripheral hypomyelination (HP:0007182)2.62635134
56Increased CSF lactate (HP:0002490)2.62410633
57Premature ovarian failure (HP:0008209)2.58225395
58Loss of speech (HP:0002371)2.58126062
59Encephalitis (HP:0002383)2.56664283
60Reticulocytopenia (HP:0001896)2.55582933
61Anxiety (HP:0000739)2.54710839
62Vaginal atresia (HP:0000148)2.53617723
63Abnormality of binocular vision (HP:0011514)2.52033537
64Diplopia (HP:0000651)2.52033537
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.51418747
66Prostate neoplasm (HP:0100787)2.50263219
67Genital tract atresia (HP:0001827)2.49603990
68Keratoconjunctivitis sicca (HP:0001097)2.49563637
69Nephrogenic diabetes insipidus (HP:0009806)2.49265714
70Glomerulonephritis (HP:0000099)2.48527373
71Medial flaring of the eyebrow (HP:0010747)2.48374514
72Hypoventilation (HP:0002791)2.47957010
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45780666
74Obstructive lung disease (HP:0006536)2.44012220
75Chronic obstructive pulmonary disease (HP:0006510)2.44012220
76Meningitis (HP:0001287)2.43714755
77Confusion (HP:0001289)2.43702172
78Impaired social interactions (HP:0000735)2.41185228
79Abnormal social behavior (HP:0012433)2.41185228
80Amblyopia (HP:0000646)2.40058573
81Inability to walk (HP:0002540)2.39870478
82IgM deficiency (HP:0002850)2.37711054
83Memory impairment (HP:0002354)2.37428409
84Premature loss of primary teeth (HP:0006323)2.37373864
85Narrow nasal bridge (HP:0000446)2.37221159
86Recurrent fungal infections (HP:0002841)2.36743646
87Hyperthyroidism (HP:0000836)2.36392832
88Supranuclear gaze palsy (HP:0000605)2.33634435
89Retinal dysplasia (HP:0007973)2.32145522
90Exertional dyspnea (HP:0002875)2.29493720
91Keratoconjunctivitis (HP:0001096)2.27709848
92Meckel diverticulum (HP:0002245)2.25819197
93Gout (HP:0001997)2.23995949
94Hypomagnesemia (HP:0002917)2.23193640
95Gaze-evoked nystagmus (HP:0000640)2.22877157
96Excessive salivation (HP:0003781)2.22556231
97Drooling (HP:0002307)2.22556231
98Epileptiform EEG discharges (HP:0011182)2.20042171
99Autoimmune thrombocytopenia (HP:0001973)2.18880300
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18219781
101T lymphocytopenia (HP:0005403)2.17829421
102Poor eye contact (HP:0000817)2.17335549
103Scanning speech (HP:0002168)2.16545028
104Increased hepatocellular lipid droplets (HP:0006565)2.15756506
105Vacuolated lymphocytes (HP:0001922)2.14670768
106Abnormality of the ileum (HP:0001549)2.12541676
107Hemoptysis (HP:0002105)2.12135330
108Colon cancer (HP:0003003)2.12100965
109Abnormal hair whorl (HP:0010721)2.12068382
110EEG with generalized epileptiform discharges (HP:0011198)2.11434462
111Cerebral inclusion bodies (HP:0100314)2.10067797
112Leukodystrophy (HP:0002415)2.09963207
113Renal Fanconi syndrome (HP:0001994)2.09804029
114Respiratory difficulties (HP:0002880)2.09682498
115Birth length less than 3rd percentile (HP:0003561)2.09490736
116Psychosis (HP:0000709)2.08944299
117Degeneration of the lateral corticospinal tracts (HP:0002314)2.07856302
118Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07856302
119Pulmonary infiltrates (HP:0002113)2.07137167
120Optic disc pallor (HP:0000543)2.06550663
121Fetal akinesia sequence (HP:0001989)2.05922921
122Thickened helices (HP:0000391)2.05862419
123Status epilepticus (HP:0002133)2.04751515
124Hepatocellular necrosis (HP:0001404)2.04465573
125Asplenia (HP:0001746)2.03826879
126Inappropriate behavior (HP:0000719)2.02359468
127Papilledema (HP:0001085)2.01225520
128Neuronal loss in central nervous system (HP:0002529)1.99324304
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.99144458
130Abnormality of the preputium (HP:0100587)1.98304517
131Amyloidosis (HP:0011034)1.97881173
132Hypsarrhythmia (HP:0002521)1.97207274
133Tinnitus (HP:0000360)1.96756924
134Poor head control (HP:0002421)1.96020093
135Gingivitis (HP:0000230)1.95529556
136Episodic fever (HP:0001954)1.95176616
137Osteomyelitis (HP:0002754)1.94183421
138Hyperphosphaturia (HP:0003109)1.93240680
139Abnormality of the prostate (HP:0008775)1.92417599
140Shoulder girdle muscle weakness (HP:0003547)1.91628579
141Urticaria (HP:0001025)1.91445392
142Abnormality of renal resorption (HP:0011038)1.90666234
143Cerebral edema (HP:0002181)1.90033097
144Hypercortisolism (HP:0001578)1.89354653
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.88869465
146Specific learning disability (HP:0001328)1.88405272
147Recurrent viral infections (HP:0004429)1.88230203
148Metabolic alkalosis (HP:0200114)1.87812294
149Abnormality of the labia minora (HP:0012880)1.87017103
150Neurofibrillary tangles (HP:0002185)1.86287507
151Neurodegeneration (HP:0002180)1.86278199
152Blue irides (HP:0000635)1.84777428
153Absent speech (HP:0001344)1.84389514
154Truncal ataxia (HP:0002078)1.84348063
155Gastrointestinal infarctions (HP:0005244)1.84162101
156Abnormality of salivation (HP:0100755)1.83780195
157Increased intramyocellular lipid droplets (HP:0012240)1.83614591
158Dysdiadochokinesis (HP:0002075)1.82698980
159Truncus arteriosus (HP:0001660)1.82286575
160Apathy (HP:0000741)1.81976435
161Abnormal ciliary motility (HP:0012262)1.81724631
162Poor coordination (HP:0002370)1.81573960
163Leukocytosis (HP:0001974)1.81502197
164Peripheral demyelination (HP:0011096)1.79574057
165Esotropia (HP:0000565)1.77345635
166Chronic mucocutaneous candidiasis (HP:0002728)1.76775299
167Recurrent cutaneous fungal infections (HP:0011370)1.76775299
168Depression (HP:0000716)1.76575799
169Progressive external ophthalmoplegia (HP:0000590)1.76427436
170Ketoacidosis (HP:0001993)1.75737210
171Axonal loss (HP:0003447)1.75581061
172Absent/shortened dynein arms (HP:0200106)1.75084170
173Dynein arm defect of respiratory motile cilia (HP:0012255)1.75084170
174Vasculitis (HP:0002633)1.74995840
175Abnormality of T cell number (HP:0011839)1.74811487
176Decreased muscle mass (HP:0003199)1.74732550
177Urinary urgency (HP:0000012)1.74399242
178Lipid accumulation in hepatocytes (HP:0006561)1.73698376
179Vertigo (HP:0002321)1.73124869
180Dysphonia (HP:0001618)1.72853726
181Abnormal number of incisors (HP:0011064)1.72798675
182Medulloblastoma (HP:0002885)1.72549370
183Cortical visual impairment (HP:0100704)1.71405466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK35.35426084
2MAP3K44.57437966
3MAP3K124.20852932
4MAP2K74.13913413
5PNCK3.30191354
6NTRK33.20789931
7BLK2.95929842
8TNIK2.89086876
9MAP2K42.80102443
10MARK12.62020369
11CASK2.58851945
12DMPK2.52448938
13MINK12.49604928
14CDC72.37549230
15VRK22.35964602
16TAF12.29455558
17IRAK22.18246606
18TXK2.06849497
19MAP3K92.04078794
20MAPKAPK51.95460556
21OXSR11.94621518
22NME11.92211910
23WNK41.91567108
24GRK51.86749984
25EPHA41.85938554
26IRAK41.84446045
27NTRK21.83546126
28ZAK1.73933949
29TSSK61.66987368
30TYK21.63269944
31PLK21.60145994
32MAP3K111.57737645
33TRIM281.56003826
34CSK1.52595844
35ACVR1B1.49689840
36NTRK11.48816659
37SIK21.44333116
38GRK71.43835766
39MAPK131.42837069
40STK391.35700987
41WNK31.34284130
42VRK11.27779519
43FES1.26740994
44MAP4K11.25335859
45CSNK1G21.24992364
46CSNK1G31.20596821
47PRKCG1.19878752
48UHMK11.18537389
49CSF1R1.15267917
50IRAK11.14751825
51CAMK2B1.13994481
52CDK191.13817045
53RIPK41.13722238
54ADRBK21.13422370
55SCYL21.12535554
56BMPR21.11275233
57MAP3K61.11104414
58CAMK2A1.11047016
59DAPK11.10213937
60SIK31.07697639
61LYN1.06142504
62CDK51.05569991
63IKBKE1.04171348
64ARAF1.02872474
65NUAK11.00891609
66YES10.98306071
67CDK80.98168358
68MYLK0.94119121
69SRPK10.91806036
70JAK20.90655955
71CDK140.86161116
72BCR0.85987736
73CAMK2G0.85232011
74PAK60.84812429
75GRK60.84623853
76MST40.84547192
77STK160.83386502
78HCK0.82200673
79ADRBK10.79891681
80DYRK1A0.78840654
81KSR10.78751661
82BUB10.77780773
83TYRO30.76449364
84CDK180.76338909
85CDK150.73911320
86MAP3K130.73534048
87PRKCE0.73110311
88CDK30.72272881
89CAMK2D0.71672818
90FGR0.67366019
91TLK10.66675648
92ZAP700.65064775
93TEC0.65045513
94NLK0.64134330
95CAMK1D0.63936582
96IKBKB0.63530822
97TTK0.63347304
98CSNK1G10.62993634
99DAPK20.62958576
100FYN0.62208507
101CAMK1G0.60788010
102CDK90.60756867
103CAMKK20.60126216
104INSRR0.59683675
105CDK11A0.58736040
106RET0.58109940
107NEK60.57908271
108PDK10.56882847
109BTK0.56702107
110TGFBR20.55217141
111ALK0.54547253
112LCK0.54255692
113JAK30.53773365
114MAP2K30.53694076
115MELK0.52017710
116CDK60.51974246
117STK240.50698769
118JAK10.49838279
119BMPR1B0.49502419
120ERBB40.49303202
121TNK20.49176349
122PHKG20.47652439
123PHKG10.47652439
124PAK30.47362052
125TESK20.47000262
126SGK4940.45898920
127SGK2230.45898920
128ATR0.45877085
129LATS20.45726552
130ROCK20.45454394
131MATK0.44734688
132KSR20.41204982
133PRKACA0.40733971
134FER0.40423866
135PRKG10.39360037
136ERBB30.39003591
137CAMK10.38779193
138PDK30.37529229
139PDK40.37529229
140MAP3K140.37469360
141CHEK20.37047000
142MKNK20.35783341
143PBK0.35552521
144PRKACB0.35343321
145MAP3K50.35323528
146PLK40.35307486
147CSNK2A10.35274101
148PIM10.34932592
149PRKCZ0.34882575
150RPS6KA50.34554636
151MAPK120.33728077
152CSNK1A1L0.33413019
153STK110.33154791
154SGK10.30414625
155SYK0.30212294
156PKN10.28826142
157CAMKK10.28436392
158MARK20.28150110
159PTK2B0.27615102
160PRKCB0.25869687
161PRKCA0.25316555

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.27204896
2Nicotine addiction_Homo sapiens_hsa050334.17500600
3Synaptic vesicle cycle_Homo sapiens_hsa047213.69536938
4Oxidative phosphorylation_Homo sapiens_hsa001903.60951382
5Collecting duct acid secretion_Homo sapiens_hsa049663.48949139
6Leishmaniasis_Homo sapiens_hsa051402.96201171
7Parkinsons disease_Homo sapiens_hsa050122.81806867
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.78656248
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59692805
10GABAergic synapse_Homo sapiens_hsa047272.58513879
11Mismatch repair_Homo sapiens_hsa034302.49323932
12Osteoclast differentiation_Homo sapiens_hsa043802.41416627
13Amphetamine addiction_Homo sapiens_hsa050312.27145931
14Homologous recombination_Homo sapiens_hsa034402.23547817
15Alzheimers disease_Homo sapiens_hsa050102.23079675
16Graft-versus-host disease_Homo sapiens_hsa053322.22623654
17Tuberculosis_Homo sapiens_hsa051522.22304346
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.20095984
19Olfactory transduction_Homo sapiens_hsa047402.12884852
20Glutamatergic synapse_Homo sapiens_hsa047242.08757815
21Morphine addiction_Homo sapiens_hsa050322.08413437
22Legionellosis_Homo sapiens_hsa051342.06340961
23Antigen processing and presentation_Homo sapiens_hsa046122.05096349
24Allograft rejection_Homo sapiens_hsa053302.02460759
25NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02443887
26Long-term potentiation_Homo sapiens_hsa047201.99356329
27Non-homologous end-joining_Homo sapiens_hsa034501.95966390
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95840091
29Vibrio cholerae infection_Homo sapiens_hsa051101.94470418
30Serotonergic synapse_Homo sapiens_hsa047261.90344216
31Circadian entrainment_Homo sapiens_hsa047131.87948781
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87687349
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86170729
34Dopaminergic synapse_Homo sapiens_hsa047281.85851638
35Butanoate metabolism_Homo sapiens_hsa006501.83827516
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81831761
37Taste transduction_Homo sapiens_hsa047421.80800992
38Huntingtons disease_Homo sapiens_hsa050161.80798342
39Chemokine signaling pathway_Homo sapiens_hsa040621.73934989
40DNA replication_Homo sapiens_hsa030301.69157468
41Cocaine addiction_Homo sapiens_hsa050301.68397261
42Cardiac muscle contraction_Homo sapiens_hsa042601.67993886
43Lysosome_Homo sapiens_hsa041421.65649446
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58832331
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54281568
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54129423
47Salivary secretion_Homo sapiens_hsa049701.52413467
48Pertussis_Homo sapiens_hsa051331.45462401
49Gastric acid secretion_Homo sapiens_hsa049711.44371764
50Cholinergic synapse_Homo sapiens_hsa047251.33830407
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31938614
52Phototransduction_Homo sapiens_hsa047441.31825430
53Calcium signaling pathway_Homo sapiens_hsa040201.31487375
54Renin secretion_Homo sapiens_hsa049241.29776542
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28541190
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25481810
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25185872
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24980705
59Systemic lupus erythematosus_Homo sapiens_hsa053221.22492206
60Long-term depression_Homo sapiens_hsa047301.22455207
61Pyruvate metabolism_Homo sapiens_hsa006201.21294298
62Spliceosome_Homo sapiens_hsa030401.19627450
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.17198950
64Insulin secretion_Homo sapiens_hsa049111.15317298
65Rheumatoid arthritis_Homo sapiens_hsa053231.10635254
66B cell receptor signaling pathway_Homo sapiens_hsa046621.10202382
67Type I diabetes mellitus_Homo sapiens_hsa049401.09490318
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09112722
69Hematopoietic cell lineage_Homo sapiens_hsa046401.06626536
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03726007
71Herpes simplex infection_Homo sapiens_hsa051681.02354637
72Phenylalanine metabolism_Homo sapiens_hsa003601.00375655
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.97167790
74Basal transcription factors_Homo sapiens_hsa030220.97138547
75RNA polymerase_Homo sapiens_hsa030200.94065833
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93724987
77Fanconi anemia pathway_Homo sapiens_hsa034600.91117051
78Toxoplasmosis_Homo sapiens_hsa051450.89789704
79Salmonella infection_Homo sapiens_hsa051320.86820688
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85816468
81Gap junction_Homo sapiens_hsa045400.85781160
82Regulation of autophagy_Homo sapiens_hsa041400.85395664
83Primary immunodeficiency_Homo sapiens_hsa053400.85031652
84Oxytocin signaling pathway_Homo sapiens_hsa049210.81789222
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80635525
86Measles_Homo sapiens_hsa051620.80574704
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80510024
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80459949
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80350845
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80313946
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80289171
92Ribosome_Homo sapiens_hsa030100.79897540
93GnRH signaling pathway_Homo sapiens_hsa049120.78395708
94Epstein-Barr virus infection_Homo sapiens_hsa051690.78189061
95Histidine metabolism_Homo sapiens_hsa003400.77785539
96Influenza A_Homo sapiens_hsa051640.77675621
97Malaria_Homo sapiens_hsa051440.76576739
98Axon guidance_Homo sapiens_hsa043600.74284634
99Shigellosis_Homo sapiens_hsa051310.73223533
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72294721
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70751399
102Viral myocarditis_Homo sapiens_hsa054160.70675007
103cAMP signaling pathway_Homo sapiens_hsa040240.69740935
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68458292
105Cell cycle_Homo sapiens_hsa041100.64365175
106Asthma_Homo sapiens_hsa053100.62776709
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60473569
108Tyrosine metabolism_Homo sapiens_hsa003500.59511124
109African trypanosomiasis_Homo sapiens_hsa051430.59284348
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57311024
111Melanogenesis_Homo sapiens_hsa049160.55696030
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54761072
113Hepatitis B_Homo sapiens_hsa051610.54647553
114Folate biosynthesis_Homo sapiens_hsa007900.54634930
115Phagosome_Homo sapiens_hsa041450.53281241
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53216300
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52095573
118Alcoholism_Homo sapiens_hsa050340.52048410
119Complement and coagulation cascades_Homo sapiens_hsa046100.49941128
120RNA transport_Homo sapiens_hsa030130.49741075
121T cell receptor signaling pathway_Homo sapiens_hsa046600.49514015
122Thyroid hormone synthesis_Homo sapiens_hsa049180.48116623
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48115273
124Estrogen signaling pathway_Homo sapiens_hsa049150.46728863
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42650114
126MAPK signaling pathway_Homo sapiens_hsa040100.41839764
127Non-small cell lung cancer_Homo sapiens_hsa052230.41618140
128Propanoate metabolism_Homo sapiens_hsa006400.39868557
129Proteasome_Homo sapiens_hsa030500.39009190
130Prion diseases_Homo sapiens_hsa050200.37115321
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36441621
132RNA degradation_Homo sapiens_hsa030180.35401305
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.35326007
134ErbB signaling pathway_Homo sapiens_hsa040120.33959922
135TNF signaling pathway_Homo sapiens_hsa046680.33013575
136Platelet activation_Homo sapiens_hsa046110.32616187
137Apoptosis_Homo sapiens_hsa042100.32585580
138Viral carcinogenesis_Homo sapiens_hsa052030.31530714
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31309841
140Pancreatic secretion_Homo sapiens_hsa049720.31148675
141Melanoma_Homo sapiens_hsa052180.30921706
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30758312
143Autoimmune thyroid disease_Homo sapiens_hsa053200.30383089
144mRNA surveillance pathway_Homo sapiens_hsa030150.30127042
145Sulfur metabolism_Homo sapiens_hsa009200.29176808
146Ras signaling pathway_Homo sapiens_hsa040140.29092464
147Nitrogen metabolism_Homo sapiens_hsa009100.28072470
148Other glycan degradation_Homo sapiens_hsa005110.27761965
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26990512
150Oocyte meiosis_Homo sapiens_hsa041140.26340536
151Glucagon signaling pathway_Homo sapiens_hsa049220.26327694
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.23126845
153Dorso-ventral axis formation_Homo sapiens_hsa043200.20885705
154Intestinal immune network for IgA production_Homo sapiens_hsa046720.20710671
155beta-Alanine metabolism_Homo sapiens_hsa004100.20292228
156Glioma_Homo sapiens_hsa052140.19724943
157Bile secretion_Homo sapiens_hsa049760.18625941
158Inositol phosphate metabolism_Homo sapiens_hsa005620.17122607
159Metabolic pathways_Homo sapiens_hsa011000.17037974
160Wnt signaling pathway_Homo sapiens_hsa043100.16426997
161Arginine biosynthesis_Homo sapiens_hsa002200.15287459
162Rap1 signaling pathway_Homo sapiens_hsa040150.14684772
163Carbon metabolism_Homo sapiens_hsa012000.14243360
164Ether lipid metabolism_Homo sapiens_hsa005650.14173987
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13196272

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