DLEU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.26841413
2DNA deamination (GO:0045006)4.21065493
3synapsis (GO:0007129)4.05429592
4behavioral response to nicotine (GO:0035095)3.88660647
5replication fork processing (GO:0031297)3.56654870
6indole-containing compound catabolic process (GO:0042436)3.51607699
7indolalkylamine catabolic process (GO:0046218)3.51607699
8tryptophan catabolic process (GO:0006569)3.51607699
9protein complex biogenesis (GO:0070271)3.50710930
10maturation of 5.8S rRNA (GO:0000460)3.48360392
11L-fucose catabolic process (GO:0042355)3.44504269
12fucose catabolic process (GO:0019317)3.44504269
13L-fucose metabolic process (GO:0042354)3.44504269
14mitochondrial respiratory chain complex assembly (GO:0033108)3.44461229
15indolalkylamine metabolic process (GO:0006586)3.38085925
16DNA double-strand break processing (GO:0000729)3.37816697
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36765400
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.36765400
19NADH dehydrogenase complex assembly (GO:0010257)3.36765400
20male meiosis I (GO:0007141)3.31932284
21pseudouridine synthesis (GO:0001522)3.29293857
22respiratory chain complex IV assembly (GO:0008535)3.29209402
23prenylation (GO:0097354)3.28483660
24protein prenylation (GO:0018342)3.28483660
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27366599
26double-strand break repair via homologous recombination (GO:0000724)3.24915377
27recombinational repair (GO:0000725)3.23131764
28reciprocal meiotic recombination (GO:0007131)3.21153961
29reciprocal DNA recombination (GO:0035825)3.21153961
30tryptophan metabolic process (GO:0006568)3.20787449
31nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20139901
32kynurenine metabolic process (GO:0070189)3.17736143
33male meiosis (GO:0007140)3.17391929
34rRNA modification (GO:0000154)3.16081428
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14883137
36water-soluble vitamin biosynthetic process (GO:0042364)3.10556423
37cellular ketone body metabolic process (GO:0046950)3.09883575
38protein-cofactor linkage (GO:0018065)3.08994979
39cytochrome complex assembly (GO:0017004)3.06660278
40preassembly of GPI anchor in ER membrane (GO:0016254)3.04721223
41response to pheromone (GO:0019236)3.04565400
42rRNA methylation (GO:0031167)3.04362079
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03191652
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01092177
45DNA methylation involved in gamete generation (GO:0043046)2.99827411
46protein K11-linked deubiquitination (GO:0035871)2.99304897
47rRNA catabolic process (GO:0016075)2.96605843
48detection of light stimulus involved in sensory perception (GO:0050962)2.96098445
49detection of light stimulus involved in visual perception (GO:0050908)2.96098445
50centriole replication (GO:0007099)2.93716456
51ATP synthesis coupled proton transport (GO:0015986)2.91059692
52energy coupled proton transport, down electrochemical gradient (GO:0015985)2.91059692
53multicellular organism reproduction (GO:0032504)2.90540063
54regulation of meiosis I (GO:0060631)2.89674319
55establishment of protein localization to mitochondrial membrane (GO:0090151)2.88348134
56neural tube formation (GO:0001841)2.88093952
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.85647483
58meiosis I (GO:0007127)2.83151503
59sulfation (GO:0051923)2.83006923
60mannosylation (GO:0097502)2.82093161
61protein neddylation (GO:0045116)2.81663520
62protein K63-linked deubiquitination (GO:0070536)2.80866862
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79669478
64ketone body metabolic process (GO:1902224)2.78755369
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78494427
66signal peptide processing (GO:0006465)2.75141352
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74843939
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74843939
69DNA replication checkpoint (GO:0000076)2.74572085
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70744322
71regulation of mitotic spindle checkpoint (GO:1903504)2.70744322
72proteasome assembly (GO:0043248)2.69393160
73meiotic chromosome segregation (GO:0045132)2.68466707
74epithelial cilium movement (GO:0003351)2.67415168
75resolution of meiotic recombination intermediates (GO:0000712)2.66820550
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.66454540
77termination of RNA polymerase III transcription (GO:0006386)2.66454540
78ubiquinone biosynthetic process (GO:0006744)2.66162962
79protein K6-linked ubiquitination (GO:0085020)2.66113596
80maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65197323
81tRNA processing (GO:0008033)2.62257642
82L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60861603
83chromatin remodeling at centromere (GO:0031055)2.59897864
84photoreceptor cell maintenance (GO:0045494)2.58773656
85dopamine transport (GO:0015872)2.56861641
86base-excision repair, AP site formation (GO:0006285)2.54756889
87peptidyl-histidine modification (GO:0018202)2.53980774
88histone exchange (GO:0043486)2.52566316
89platelet dense granule organization (GO:0060155)2.51530881
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51377846
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.51377846
92DNA demethylation (GO:0080111)2.51023167
93CENP-A containing nucleosome assembly (GO:0034080)2.50486967
94mitochondrial RNA metabolic process (GO:0000959)2.48402198
95adenosine metabolic process (GO:0046085)2.46253527
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.46163552
97indole-containing compound metabolic process (GO:0042430)2.45113210
98nucleotide transmembrane transport (GO:1901679)2.45007041
99oxidative demethylation (GO:0070989)2.44173080
100regulation of DNA endoreduplication (GO:0032875)2.43578750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.41961352
2ZNF274_21170338_ChIP-Seq_K562_Hela3.31674476
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.87394112
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.71919261
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67020597
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.66407749
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64022941
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59896561
9IGF1R_20145208_ChIP-Seq_DFB_Human2.50046442
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.48497119
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48092355
12EWS_26573619_Chip-Seq_HEK293_Human2.40536786
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36962415
14GBX2_23144817_ChIP-Seq_PC3_Human2.29261590
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26197402
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.20037004
17FUS_26573619_Chip-Seq_HEK293_Human2.19153270
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97807617
19ER_23166858_ChIP-Seq_MCF-7_Human1.91548404
20VDR_23849224_ChIP-Seq_CD4+_Human1.90948222
21ELK1_19687146_ChIP-ChIP_HELA_Human1.90050558
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88999633
23EZH2_22144423_ChIP-Seq_EOC_Human1.86588578
24TAF15_26573619_Chip-Seq_HEK293_Human1.86521626
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.86401677
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81465243
27P300_19829295_ChIP-Seq_ESCs_Human1.80546846
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79526404
29MYC_18940864_ChIP-ChIP_HL60_Human1.74196068
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.70287350
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66218016
32IRF1_19129219_ChIP-ChIP_H3396_Human1.63708691
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62662433
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.60237899
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58480168
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55217021
37TP53_22573176_ChIP-Seq_HFKS_Human1.49957326
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45674846
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42981667
40FOXP3_21729870_ChIP-Seq_TREG_Human1.42837940
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42591184
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41172943
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39648352
44STAT3_23295773_ChIP-Seq_U87_Human1.37739187
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36499374
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36342399
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.36342399
48CBP_20019798_ChIP-Seq_JUKART_Human1.35524824
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35524824
50BCAT_22108803_ChIP-Seq_LS180_Human1.35098477
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.31357930
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27929860
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.26414764
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25757715
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24958709
56AR_20517297_ChIP-Seq_VCAP_Human1.24108756
57NANOG_19829295_ChIP-Seq_ESCs_Human1.23659315
58SOX2_19829295_ChIP-Seq_ESCs_Human1.23659315
59TCF4_23295773_ChIP-Seq_U87_Human1.23053951
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.21017633
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.20408276
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19456702
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18464492
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18339574
65SMAD4_21799915_ChIP-Seq_A2780_Human1.18161842
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17960934
67TCF4_22108803_ChIP-Seq_LS180_Human1.17038998
68AR_25329375_ChIP-Seq_VCAP_Human1.16513319
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15615994
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14269658
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14269658
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12366503
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10222213
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10096748
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.09321630
76HOXB7_26014856_ChIP-Seq_BT474_Human1.08152153
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07092728
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06512173
79NCOR_22424771_ChIP-Seq_293T_Human1.06212219
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04662108
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.03736568
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03249896
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03077240
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.03009066
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02731191
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01544520
87RUNX2_22187159_ChIP-Seq_PCA_Human1.01309464
88GATA3_26560356_Chip-Seq_TH2_Human1.00808802
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.00763290
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.98803585
91BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97467334
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.96948320
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96751347
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96401474
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96079955
96CDX2_22108803_ChIP-Seq_LS180_Human0.95978561
97FOXH1_21741376_ChIP-Seq_EPCs_Human0.95959705
98AR_21572438_ChIP-Seq_LNCaP_Human0.95075089
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.92050760
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91402935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.61135438
2MP0003195_calcinosis2.94178654
3MP0008057_abnormal_DNA_replication2.76642097
4MP0000569_abnormal_digit_pigmentation2.70941767
5MP0008058_abnormal_DNA_repair2.51812543
6MP0003718_maternal_effect2.36557231
7MP0006292_abnormal_olfactory_placode2.34099239
8MP0006072_abnormal_retinal_apoptosis2.28063529
9MP0005551_abnormal_eye_electrophysiolog2.20181316
10MP0002102_abnormal_ear_morphology2.15608542
11MP0000372_irregular_coat_pigmentation1.99435571
12MP0005410_abnormal_fertilization1.95418396
13MP0003693_abnormal_embryo_hatching1.94224432
14MP0008872_abnormal_physiological_respon1.92475208
15MP0010094_abnormal_chromosome_stability1.92004306
16MP0002160_abnormal_reproductive_system1.86562825
17MP0002837_dystrophic_cardiac_calcinosis1.84569230
18MP0000427_abnormal_hair_cycle1.83227521
19MP0001968_abnormal_touch/_nociception1.81666088
20MP0008875_abnormal_xenobiotic_pharmacok1.80717572
21MP0003646_muscle_fatigue1.79870289
22MP0008995_early_reproductive_senescence1.76694890
23MP0002163_abnormal_gland_morphology1.70308963
24MP0005253_abnormal_eye_physiology1.68645692
25MP0003787_abnormal_imprinting1.68248269
26MP0005645_abnormal_hypothalamus_physiol1.67381523
27MP0002736_abnormal_nociception_after1.66362325
28MP0005389_reproductive_system_phenotype1.65282911
29MP0009046_muscle_twitch1.63566680
30MP0004147_increased_porphyrin_level1.62750456
31MP0004142_abnormal_muscle_tone1.61747730
32MP0005646_abnormal_pituitary_gland1.59787378
33MP0001929_abnormal_gametogenesis1.56504358
34MP0005174_abnormal_tail_pigmentation1.56056322
35MP0002938_white_spotting1.47949715
36MP0002876_abnormal_thyroid_physiology1.45442191
37MP0003890_abnormal_embryonic-extraembry1.43629592
38MP0003136_yellow_coat_color1.43501951
39MP0002210_abnormal_sex_determination1.38833326
40MP0003698_abnormal_male_reproductive1.38562297
41MP0009697_abnormal_copulation1.37645860
42MP0004043_abnormal_pH_regulation1.36650654
43MP0001986_abnormal_taste_sensitivity1.35491361
44MP0002638_abnormal_pupillary_reflex1.33122943
45MP0003786_premature_aging1.29358955
46MP0008961_abnormal_basal_metabolism1.28138499
47MP0003183_abnormal_peptide_metabolism1.27392618
48MP0000631_abnormal_neuroendocrine_gland1.24851128
49MP0006036_abnormal_mitochondrial_physio1.23459332
50MP0003806_abnormal_nucleotide_metabolis1.23389852
51MP0000653_abnormal_sex_gland1.21341174
52MP0005379_endocrine/exocrine_gland_phen1.19632051
53MP0005075_abnormal_melanosome_morpholog1.17898938
54MP0001485_abnormal_pinna_reflex1.16739755
55MP0009745_abnormal_behavioral_response1.15982133
56MP0001145_abnormal_male_reproductive1.15542267
57MP0006276_abnormal_autonomic_nervous1.15107444
58MP0005084_abnormal_gallbladder_morpholo1.12837437
59MP0003011_delayed_dark_adaptation1.11592032
60MP0000383_abnormal_hair_follicle1.10475741
61MP0006035_abnormal_mitochondrial_morpho1.09934874
62MP0001919_abnormal_reproductive_system1.09506147
63MP0001984_abnormal_olfaction1.08607591
64MP0002095_abnormal_skin_pigmentation1.07912879
65MP0004215_abnormal_myocardial_fiber1.06564666
66MP0002653_abnormal_ependyma_morphology1.04689942
67MP0002272_abnormal_nervous_system1.00835979
68MP0001119_abnormal_female_reproductive0.97123147
69MP0001764_abnormal_homeostasis0.96716669
70MP0001501_abnormal_sleep_pattern0.95780067
71MP0005670_abnormal_white_adipose0.95072522
72MP0002277_abnormal_respiratory_mucosa0.91323419
73MP0005395_other_phenotype0.89709070
74MP0003077_abnormal_cell_cycle0.89463414
75MP0002928_abnormal_bile_duct0.88807050
76MP0010386_abnormal_urinary_bladder0.85492022
77MP0002138_abnormal_hepatobiliary_system0.85144848
78MP0008775_abnormal_heart_ventricle0.84890797
79MP0004133_heterotaxia0.84041811
80MP0004145_abnormal_muscle_electrophysio0.83921313
81MP0002735_abnormal_chemical_nociception0.83813356
82MP0000230_abnormal_systemic_arterial0.82864816
83MP0003121_genomic_imprinting0.82307461
84MP0005266_abnormal_metabolism0.81866533
85MP0002693_abnormal_pancreas_physiology0.81518406
86MP0005332_abnormal_amino_acid0.80601270
87MP0003252_abnormal_bile_duct0.78633067
88MP0001293_anophthalmia0.75948933
89MP0008789_abnormal_olfactory_epithelium0.75509483
90MP0005647_abnormal_sex_gland0.74849410
91MP0005195_abnormal_posterior_eye0.74077097
92MP0003186_abnormal_redox_activity0.73849576
93MP0008007_abnormal_cellular_replicative0.72096987
94MP0000015_abnormal_ear_pigmentation0.72005536
95MP0004885_abnormal_endolymph0.71507936
96MP0000647_abnormal_sebaceous_gland0.71086195
97MP0001486_abnormal_startle_reflex0.70935069
98MP0002067_abnormal_sensory_capabilities0.70770426
99MP0004957_abnormal_blastocyst_morpholog0.70744456
100MP0002234_abnormal_pharynx_morphology0.67276953

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.11701822
2Pancreatic fibrosis (HP:0100732)3.77809366
3Molar tooth sign on MRI (HP:0002419)3.64566607
4Abnormality of midbrain morphology (HP:0002418)3.64566607
5True hermaphroditism (HP:0010459)3.57239123
6Congenital stationary night blindness (HP:0007642)3.37736814
7Nephronophthisis (HP:0000090)3.21980536
8Abnormality of the renal cortex (HP:0011035)3.21356771
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.17050911
10Abnormality of alanine metabolism (HP:0010916)3.17050911
11Hyperalaninemia (HP:0003348)3.17050911
12Attenuation of retinal blood vessels (HP:0007843)2.97950485
13Abnormality of the renal medulla (HP:0100957)2.86558890
14Chronic hepatic failure (HP:0100626)2.70982436
15Type II lissencephaly (HP:0007260)2.65384399
16Acute necrotizing encephalopathy (HP:0006965)2.59296355
17Medial flaring of the eyebrow (HP:0010747)2.56482941
18Abolished electroretinogram (ERG) (HP:0000550)2.55855243
19Increased CSF lactate (HP:0002490)2.51506092
20Renal cortical cysts (HP:0000803)2.50549581
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.47651966
22Acute encephalopathy (HP:0006846)2.47600586
23Tubular atrophy (HP:0000092)2.47559794
24Gaze-evoked nystagmus (HP:0000640)2.44274394
25Mitochondrial inheritance (HP:0001427)2.39850442
26Aplasia/Hypoplasia of the tibia (HP:0005772)2.38689064
27Abnormality of the pons (HP:0007361)2.37103564
28Cystic liver disease (HP:0006706)2.37068869
29Birth length less than 3rd percentile (HP:0003561)2.34088889
30Large for gestational age (HP:0001520)2.29988358
31Hypoplasia of the pons (HP:0012110)2.29925785
32Progressive macrocephaly (HP:0004481)2.28926490
33Abnormal mitochondria in muscle tissue (HP:0008316)2.27176636
34Congenital, generalized hypertrichosis (HP:0004540)2.27055843
353-Methylglutaconic aciduria (HP:0003535)2.25635546
36Male pseudohermaphroditism (HP:0000037)2.24276926
37Pendular nystagmus (HP:0012043)2.23265653
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17874277
39Decreased central vision (HP:0007663)2.17694192
40Volvulus (HP:0002580)2.16414028
41Sclerocornea (HP:0000647)2.16143838
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15298641
43Furrowed tongue (HP:0000221)2.12315481
44Oligodactyly (hands) (HP:0001180)2.12055506
45Abnormality of the ileum (HP:0001549)2.11534340
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.10831671
47Absent/shortened dynein arms (HP:0200106)2.07782249
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.07782249
49Inability to walk (HP:0002540)2.07568655
50Progressive inability to walk (HP:0002505)2.07431102
51Hepatic necrosis (HP:0002605)2.06302052
52Hyperventilation (HP:0002883)2.06116186
53Abnormal biliary tract physiology (HP:0012439)2.05372123
54Bile duct proliferation (HP:0001408)2.05372123
55Meckel diverticulum (HP:0002245)2.05198729
56Genetic anticipation (HP:0003743)2.04879958
57Absent thumb (HP:0009777)2.04412085
58Abnormal rod and cone electroretinograms (HP:0008323)2.04388521
59Cerebellar dysplasia (HP:0007033)2.03728021
60Polydipsia (HP:0001959)2.03616819
61Abnormal drinking behavior (HP:0030082)2.03616819
62Chromsome breakage (HP:0040012)2.03439241
63Methylmalonic acidemia (HP:0002912)2.00024922
64Concave nail (HP:0001598)1.98478186
65Clubbing of toes (HP:0100760)1.97061387
66Hepatocellular necrosis (HP:0001404)1.96659322
67Abnormality of the renal collecting system (HP:0004742)1.96512562
68Clumsiness (HP:0002312)1.96414793
69Anencephaly (HP:0002323)1.94753649
70Abnormality of chromosome stability (HP:0003220)1.94213131
71Increased serum lactate (HP:0002151)1.93823867
72Sloping forehead (HP:0000340)1.91885369
73Constricted visual fields (HP:0001133)1.90694086
74Abnormality of macular pigmentation (HP:0008002)1.90632056
75Patellar aplasia (HP:0006443)1.89621600
76Duplicated collecting system (HP:0000081)1.88733065
77Congenital hepatic fibrosis (HP:0002612)1.87282191
78Colon cancer (HP:0003003)1.86521802
79Lipid accumulation in hepatocytes (HP:0006561)1.83568825
80Bony spicule pigmentary retinopathy (HP:0007737)1.83143299
81Methylmalonic aciduria (HP:0012120)1.81957931
82Optic disc pallor (HP:0000543)1.81139228
83Abnormality of the preputium (HP:0100587)1.81088020
84Aplasia/Hypoplasia of the patella (HP:0006498)1.81040670
85Stomach cancer (HP:0012126)1.80883475
86Hypothermia (HP:0002045)1.77425694
87Febrile seizures (HP:0002373)1.77301807
88Congenital primary aphakia (HP:0007707)1.76724496
89Abnormality of the labia minora (HP:0012880)1.76473842
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75964559
91Ectopic kidney (HP:0000086)1.75644785
92Abnormal number of erythroid precursors (HP:0012131)1.75555895
93Progressive cerebellar ataxia (HP:0002073)1.74942501
94Protruding tongue (HP:0010808)1.74851323
95Abnormal protein glycosylation (HP:0012346)1.74629063
96Abnormal glycosylation (HP:0012345)1.74629063
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74629063
98Abnormal protein N-linked glycosylation (HP:0012347)1.74629063
99Lissencephaly (HP:0001339)1.73926796
100Chorioretinal atrophy (HP:0000533)1.72307189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.00545555
2ZAK3.34479600
3BMPR1B3.09502240
4ACVR1B2.75777550
5MAP4K22.68999409
6NUAK12.56162783
7TLK12.50923113
8ADRBK22.45517671
9MST42.31124009
10GRK12.18104630
11WNK41.97941986
12INSRR1.89600756
13TAOK31.88571613
14WNK31.85291963
15BRSK21.71546129
16PINK11.67243031
17OXSR11.60327748
18STK391.58598822
19BUB11.54179825
20MKNK21.50269624
21PIK3CG1.48374375
22TEC1.43177186
23PLK41.41947231
24VRK11.39745669
25TXK1.31018893
26EIF2AK31.27717610
27PNCK1.26078582
28TRIM281.23968959
29TNIK1.23605486
30WEE11.23390518
31CDC71.15143728
32MAPK131.10342453
33PLK31.08645200
34STK31.00735456
35ADRBK11.00307548
36MAP3K40.99445089
37PBK0.95002146
38MKNK10.92777391
39STK38L0.88947190
40PTK2B0.88654824
41NME10.88359701
42VRK20.85724686
43IKBKB0.84523723
44MAP2K60.83175684
45RPS6KA50.82635653
46PLK10.81729468
47PLK20.81028862
48TGFBR10.78740085
49SRPK10.76892250
50ATR0.73277530
51NEK20.72425413
52MUSK0.70358370
53STK160.70024498
54CAMKK20.69513684
55MAPKAPK30.68301697
56CHEK20.67588726
57PRKCE0.66107653
58CASK0.63829259
59PRKCG0.62814925
60AKT30.61470677
61DAPK20.60966855
62CSNK1G10.60732114
63PIK3CA0.58517949
64EIF2AK10.57972138
65PAK30.57928254
66CSNK1A1L0.57876982
67TTK0.57545817
68BMPR20.56991994
69ITK0.54796528
70DYRK20.53285544
71PASK0.52972699
72ATM0.52907780
73MARK30.52739032
74PRKCQ0.50762893
75CSNK1G30.49275529
76CDK80.48035767
77PRKCI0.46893740
78STK40.46130378
79CDK30.45922539
80OBSCN0.44894686
81CSNK1G20.44853680
82IRAK10.44555949
83BCKDK0.43955640
84MAP2K70.42228950
85EIF2AK20.42141753
86NLK0.39510898
87TSSK60.39253040
88MAPKAPK50.38858953
89AURKB0.38080929
90BTK0.37515091
91CHUK0.36338798
92SYK0.35492336
93KIT0.35236289
94NEK10.33687603
95WNK10.33506299
96CSNK1D0.33164258
97PIM10.33073361
98PHKG20.31929951
99PHKG10.31929951
100CDK190.31305610

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.86924220
2RNA polymerase_Homo sapiens_hsa030202.68987992
3Oxidative phosphorylation_Homo sapiens_hsa001902.60791416
4Fanconi anemia pathway_Homo sapiens_hsa034602.49091427
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30305031
6Phototransduction_Homo sapiens_hsa047442.28897682
7Proteasome_Homo sapiens_hsa030502.27960675
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15557675
9Basal transcription factors_Homo sapiens_hsa030222.15336953
10Parkinsons disease_Homo sapiens_hsa050122.10982594
11Nitrogen metabolism_Homo sapiens_hsa009102.10874782
12One carbon pool by folate_Homo sapiens_hsa006702.10528650
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04958685
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04126004
15Linoleic acid metabolism_Homo sapiens_hsa005911.99054349
16Butanoate metabolism_Homo sapiens_hsa006501.98605294
17Selenocompound metabolism_Homo sapiens_hsa004501.94181448
18Protein export_Homo sapiens_hsa030601.89297899
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.81558137
20Mismatch repair_Homo sapiens_hsa034301.78747781
21Ribosome_Homo sapiens_hsa030101.75895080
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74724961
23RNA degradation_Homo sapiens_hsa030181.73600214
24Huntingtons disease_Homo sapiens_hsa050161.59239761
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55491724
26Caffeine metabolism_Homo sapiens_hsa002321.52313027
27Tryptophan metabolism_Homo sapiens_hsa003801.49532029
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49015074
29Non-homologous end-joining_Homo sapiens_hsa034501.42101141
30Propanoate metabolism_Homo sapiens_hsa006401.41431867
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39660845
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38427594
33Nucleotide excision repair_Homo sapiens_hsa034201.34744494
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31175547
35Alzheimers disease_Homo sapiens_hsa050101.24549011
36Pyrimidine metabolism_Homo sapiens_hsa002401.21230065
37Olfactory transduction_Homo sapiens_hsa047401.19436243
38Purine metabolism_Homo sapiens_hsa002301.16604030
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15466496
40DNA replication_Homo sapiens_hsa030301.12702963
41Ether lipid metabolism_Homo sapiens_hsa005651.12490961
42Peroxisome_Homo sapiens_hsa041461.09346255
43RNA transport_Homo sapiens_hsa030131.09275252
44Base excision repair_Homo sapiens_hsa034101.05793954
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.03677733
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02663961
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00510478
48Chemical carcinogenesis_Homo sapiens_hsa052040.98587582
49Taste transduction_Homo sapiens_hsa047420.98342656
50Regulation of autophagy_Homo sapiens_hsa041400.97558916
51Intestinal immune network for IgA production_Homo sapiens_hsa046720.96349911
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96135092
53Arachidonic acid metabolism_Homo sapiens_hsa005900.93415153
54Nicotine addiction_Homo sapiens_hsa050330.93084006
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92356272
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92087180
57Sulfur relay system_Homo sapiens_hsa041220.89048371
58ABC transporters_Homo sapiens_hsa020100.88690822
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84037276
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.83720313
61Cardiac muscle contraction_Homo sapiens_hsa042600.80155485
62Retinol metabolism_Homo sapiens_hsa008300.78073322
63Primary immunodeficiency_Homo sapiens_hsa053400.77833430
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74270485
65Metabolic pathways_Homo sapiens_hsa011000.69705568
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69595915
67Graft-versus-host disease_Homo sapiens_hsa053320.68448421
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.67468485
69Asthma_Homo sapiens_hsa053100.66867347
70beta-Alanine metabolism_Homo sapiens_hsa004100.65030692
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62592778
72Spliceosome_Homo sapiens_hsa030400.61596259
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60585799
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58871012
75Sulfur metabolism_Homo sapiens_hsa009200.58609580
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57114704
77Vitamin digestion and absorption_Homo sapiens_hsa049770.56049976
78Cell cycle_Homo sapiens_hsa041100.55873453
79Systemic lupus erythematosus_Homo sapiens_hsa053220.54848219
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53733620
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53186619
82Ovarian steroidogenesis_Homo sapiens_hsa049130.52805009
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51865706
84Glycerolipid metabolism_Homo sapiens_hsa005610.51644319
85Glutathione metabolism_Homo sapiens_hsa004800.51614766
86p53 signaling pathway_Homo sapiens_hsa041150.50716931
87Serotonergic synapse_Homo sapiens_hsa047260.49910488
88Collecting duct acid secretion_Homo sapiens_hsa049660.46790971
89Fatty acid elongation_Homo sapiens_hsa000620.46507012
90Circadian rhythm_Homo sapiens_hsa047100.44658613
91Fatty acid degradation_Homo sapiens_hsa000710.44504256
92Type I diabetes mellitus_Homo sapiens_hsa049400.44034464
93Morphine addiction_Homo sapiens_hsa050320.43597776
94Dorso-ventral axis formation_Homo sapiens_hsa043200.41914920
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41486127
96Fatty acid metabolism_Homo sapiens_hsa012120.40250459
97Oocyte meiosis_Homo sapiens_hsa041140.33983815
98Folate biosynthesis_Homo sapiens_hsa007900.32197785
99Fatty acid biosynthesis_Homo sapiens_hsa000610.32193653
100Calcium signaling pathway_Homo sapiens_hsa040200.31760069

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