DLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.00135948
2vascular endothelial growth factor signaling pathway (GO:0038084)4.71115018
3retina vasculature morphogenesis in camera-type eye (GO:0061299)4.59728449
4low-density lipoprotein particle clearance (GO:0034383)4.51753133
5regulation of sequestering of triglyceride (GO:0010889)4.23234927
6fatty acid transmembrane transport (GO:1902001)4.17824241
7positive regulation of fatty acid beta-oxidation (GO:0032000)4.16479239
8wound healing, spreading of epidermal cells (GO:0035313)4.15174433
9lymph vessel development (GO:0001945)3.99769038
10cell migration involved in sprouting angiogenesis (GO:0002042)3.99239706
11endodermal cell differentiation (GO:0035987)3.98602414
12negative regulation of smooth muscle cell migration (GO:0014912)3.98386021
13carnitine shuttle (GO:0006853)3.96332175
14positive regulation of fatty acid oxidation (GO:0046321)3.94802777
15basement membrane organization (GO:0071711)3.85648190
16white fat cell differentiation (GO:0050872)3.80412040
17glomerular filtration (GO:0003094)3.77934569
18cell adhesion mediated by integrin (GO:0033627)3.77294789
19negative regulation of fatty acid transport (GO:2000192)3.77251400
20protein heterotrimerization (GO:0070208)3.75211797
21renal filtration (GO:0097205)3.68386020
22triglyceride catabolic process (GO:0019433)3.57273784
23glomerular basement membrane development (GO:0032836)3.53874563
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.47541201
25cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.43979740
26kidney mesenchyme development (GO:0072074)3.40053322
27brown fat cell differentiation (GO:0050873)3.39274865
28ovulation from ovarian follicle (GO:0001542)3.32607749
29lymphangiogenesis (GO:0001946)3.32027119
30acylglycerol catabolic process (GO:0046464)3.31609945
31neutral lipid catabolic process (GO:0046461)3.31609945
32blood vessel endothelial cell migration (GO:0043534)3.28394372
33extracellular matrix assembly (GO:0085029)3.28307678
34endothelial cell morphogenesis (GO:0001886)3.25027449
35substrate adhesion-dependent cell spreading (GO:0034446)3.23229342
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.22226841
37axon extension involved in axon guidance (GO:0048846)3.22226841
38regulation of fatty acid beta-oxidation (GO:0031998)3.19676324
39regulation of fatty acid oxidation (GO:0046320)3.18150265
40substrate-dependent cell migration (GO:0006929)3.17767720
41cardiac myofibril assembly (GO:0055003)3.17342377
42biotin metabolic process (GO:0006768)3.17246623
43extracellular fibril organization (GO:0043206)3.16337523
44insulin-like growth factor receptor signaling pathway (GO:0048009)3.14857143
45skin morphogenesis (GO:0043589)3.13363292
46paraxial mesoderm development (GO:0048339)3.12609204
47hippo signaling (GO:0035329)3.10500280
48surfactant homeostasis (GO:0043129)3.06119160
49regulation of tight junction assembly (GO:2000810)3.04986171
50pericardium development (GO:0060039)3.01418660
51metanephric mesenchyme development (GO:0072075)2.98741506
52wound healing, spreading of cells (GO:0044319)2.95599873
53regulation of plasminogen activation (GO:0010755)2.95083170
54mesodermal cell differentiation (GO:0048333)2.93712365
55sprouting angiogenesis (GO:0002040)2.92469575
56plasma membrane repair (GO:0001778)2.92209512
57coronary vasculature morphogenesis (GO:0060977)2.90547536
58regulation of transforming growth factor beta2 production (GO:0032909)2.90254497
59vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88218495
60collagen fibril organization (GO:0030199)2.87680278
61regulation of endothelial cell differentiation (GO:0045601)2.87518421
62regulation of integrin-mediated signaling pathway (GO:2001044)2.87069691
63regulation of cholesterol storage (GO:0010885)2.85900199
64fatty acid beta-oxidation (GO:0006635)2.85162289
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84959508
66collagen metabolic process (GO:0032963)2.84112265
67regulation of p38MAPK cascade (GO:1900744)2.83722972
68heart trabecula formation (GO:0060347)2.82696426
69Notch signaling involved in heart development (GO:0061314)2.82435201
70smooth muscle tissue development (GO:0048745)2.82256036
71carnitine transmembrane transport (GO:1902603)2.82233794
72endocrine hormone secretion (GO:0060986)2.81213427
73* cell-substrate junction assembly (GO:0007044)2.79873694
74peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.79456956
75regulation of hippo signaling (GO:0035330)2.78384070
76venous blood vessel morphogenesis (GO:0048845)2.76923600
77valine metabolic process (GO:0006573)2.76827694
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.74668391
79glomerular visceral epithelial cell development (GO:0072015)2.73493799
80positive regulation of fibroblast migration (GO:0010763)2.71223245
81negative regulation of chondrocyte differentiation (GO:0032331)2.70565121
82anterior/posterior axis specification, embryo (GO:0008595)2.69442161
83patterning of blood vessels (GO:0001569)2.69003536
84endocardial cushion development (GO:0003197)2.69003532
85protein localization to cell surface (GO:0034394)2.68818911
86neural crest cell development (GO:0014032)2.68416231
87phagocytosis, recognition (GO:0006910)2.65967885
88blood vessel maturation (GO:0001955)2.65750583
89positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.65719395
90regulation of axon extension involved in axon guidance (GO:0048841)2.65354091
91positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64792343
92regulation of endothelial cell apoptotic process (GO:2000351)2.64780612
93fibril organization (GO:0097435)2.64237364
94blood vessel remodeling (GO:0001974)2.63594462
95blood vessel morphogenesis (GO:0048514)2.63583594
96collagen catabolic process (GO:0030574)2.63285340
97positive regulation of osteoblast proliferation (GO:0033690)2.63102107
98artery morphogenesis (GO:0048844)2.63051571
99positive regulation of smooth muscle cell migration (GO:0014911)2.62622168
100mesenchymal-epithelial cell signaling (GO:0060638)2.62450663
101multicellular organismal macromolecule metabolic process (GO:0044259)2.61993964
102bone trabecula formation (GO:0060346)2.61392794
103positive regulation of glycogen biosynthetic process (GO:0045725)2.61095975
104positive regulation of endothelial cell migration (GO:0010595)2.58760555
105endothelium development (GO:0003158)2.57487205
106cardiac muscle cell proliferation (GO:0060038)2.57066162
107epoxygenase P450 pathway (GO:0019373)2.56676807
108ventricular cardiac muscle cell development (GO:0055015)2.56032011
109carnitine transport (GO:0015879)2.55397297
110amino-acid betaine transport (GO:0015838)2.55397297
111positive regulation of p38MAPK cascade (GO:1900745)2.54889332
112regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.54476247
113cell-matrix adhesion (GO:0007160)2.54148942
114atrioventricular valve morphogenesis (GO:0003181)2.54078848
115negative regulation of catenin import into nucleus (GO:0035414)2.53465245
116SMAD protein complex assembly (GO:0007183)2.53371164
117lipid particle organization (GO:0034389)2.53344562
118cell-substrate adhesion (GO:0031589)2.53222306
119extracellular matrix disassembly (GO:0022617)2.52873469
120trabecula formation (GO:0060343)2.52836237
121regulation of smooth muscle cell migration (GO:0014910)2.52291746
122* adherens junction assembly (GO:0034333)2.51790767
123extracellular matrix organization (GO:0030198)2.50049585
124multicellular organismal metabolic process (GO:0044236)2.49841939
125extracellular structure organization (GO:0043062)2.49194494
126fatty acid oxidation (GO:0019395)2.49104115
127chemical homeostasis within a tissue (GO:0048875)2.49044824
128positive regulation of lipid catabolic process (GO:0050996)2.48596451
129dermatan sulfate biosynthetic process (GO:0030208)2.47810339
130cell migration involved in heart development (GO:0060973)2.47453465
131negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.46728487
132mesenchymal cell development (GO:0014031)2.46336901
133regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45543104
134extracellular regulation of signal transduction (GO:1900115)2.44863261
135extracellular negative regulation of signal transduction (GO:1900116)2.44863261
136fatty acid homeostasis (GO:0055089)2.44767211
137endothelial cell proliferation (GO:0001935)2.44481857
138gap junction assembly (GO:0016264)2.43880110
139regulation of SMAD protein import into nucleus (GO:0060390)2.43516971
140lipid oxidation (GO:0034440)2.43109443
141positive regulation of fatty acid metabolic process (GO:0045923)2.42047713
142epithelial cell-cell adhesion (GO:0090136)2.41859283
143* focal adhesion assembly (GO:0048041)2.41349718
144* cell-substrate adherens junction assembly (GO:0007045)2.41349718
145regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40768183
146negative regulation of DNA biosynthetic process (GO:2000279)2.39851893
147vasculogenesis (GO:0001570)2.39422437
148acetyl-CoA metabolic process (GO:0006084)2.39367444
149apoptotic cell clearance (GO:0043277)2.38917861
150branching involved in salivary gland morphogenesis (GO:0060445)2.38143140
151regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36109316
152alpha-linolenic acid metabolic process (GO:0036109)2.35954522
153complement activation, alternative pathway (GO:0006957)2.35915511
154glomerular epithelial cell development (GO:0072310)2.35702940
155embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35477013
156positive regulation of glucose import (GO:0046326)2.34822123
157negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.34133982
158embryonic placenta development (GO:0001892)2.34042845
159myofibril assembly (GO:0030239)2.33610319
160positive regulation of endothelial cell apoptotic process (GO:2000353)2.33322462
161sequestering of extracellular ligand from receptor (GO:0035581)2.33271241
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.32509648
163endothelial cell chemotaxis (GO:0035767)2.31377286
164negative regulation of fibrinolysis (GO:0051918)2.30820068
165intracellular lipid transport (GO:0032365)2.30337169
166fibroblast migration (GO:0010761)2.29733899
167plasma lipoprotein particle clearance (GO:0034381)2.29678053
168negative regulation of protein autophosphorylation (GO:0031953)2.29340223
169endothelial cell migration (GO:0043542)2.28865693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.43495058
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.81752240
3CLOCK_20551151_ChIP-Seq_293T_Human3.26075225
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.92471079
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67305003
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.59424748
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43077182
8* EP300_21415370_ChIP-Seq_HL-1_Mouse2.31267881
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.30595615
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.19832453
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19493615
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13601297
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.10383853
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.08965644
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07206435
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07206435
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07206435
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.01193808
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87446868
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79649573
21* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76831684
22TP53_18474530_ChIP-ChIP_U2OS_Human1.72653265
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69922284
24HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69546768
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67612882
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.66317506
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.66317506
28ZNF263_19887448_ChIP-Seq_K562_Human1.63245801
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.61829602
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59975960
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59585283
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57814612
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.53854152
34GBX2_23144817_ChIP-Seq_PC3_Human1.51600488
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51525351
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50243062
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47615870
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47260556
39* ISL1_27105846_Chip-Seq_CPCs_Mouse1.44777808
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44443090
41CJUN_26792858_Chip-Seq_BT549_Human1.44433640
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.43967222
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43102678
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43035002
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.41543683
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40941850
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40795844
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.39410267
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.38609028
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.37441572
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.37131509
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37003597
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35453727
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35160067
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32784621
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31857859
57TCF4_18268006_ChIP-ChIP_LS174T_Human1.31831329
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30685261
59* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30167252
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29950551
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29950551
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28690909
63* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28284138
64* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27792476
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27348200
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27348200
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.27121756
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.26045614
69* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25477003
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23158524
71AHR_22903824_ChIP-Seq_MCF-7_Human1.22991945
72* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20319754
73* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20142694
74JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19689811
75SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18886549
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18676103
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16144428
78* WT1_19549856_ChIP-ChIP_CCG9911_Human1.14812799
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.14716964
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13380110
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13312252
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12731064
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12108536
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11758695
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11117406
86BCAT_22108803_ChIP-Seq_LS180_Human1.11115179
87TP53_16413492_ChIP-PET_HCT116_Human1.10553722
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.10455156
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10174487
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.09935504
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09717858
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08916451
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08336523
94NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08288073
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08288073
96* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07645734
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07582340
98* BRD4_25478319_ChIP-Seq_HGPS_Human1.07569336
99SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07501605
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07142724
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07066873
102* KDM2B_26808549_Chip-Seq_K562_Human1.06916431
103TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06246379
104SA1_22415368_ChIP-Seq_MEFs_Mouse1.05885815
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05437324
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04653914
107* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04512898
108* SMAD4_21799915_ChIP-Seq_A2780_Human1.03891811
109* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03759762
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03235669
111SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02808444
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02783096
113JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02421330
114UBF1/2_26484160_Chip-Seq_HMECs_Human1.02258052
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01973657
116TP53_23651856_ChIP-Seq_MEFs_Mouse1.00719743
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00486715
118NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99228411
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99018465
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.98777306
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97770602
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97682880
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97300658
124TP53_20018659_ChIP-ChIP_R1E_Mouse0.97120142
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96028327
126* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95320777
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94883297
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.94735596
129EZH2_27304074_Chip-Seq_ESCs_Mouse0.94319770
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93750616
131* SMAD3_21741376_ChIP-Seq_HESCs_Human0.93590679
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.92384062
133* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91771906
134DROSHA_22980978_ChIP-Seq_HELA_Human0.91294166
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90302429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.36101488
2MP0004272_abnormal_basement_membrane4.11236457
3MP0005670_abnormal_white_adipose3.72245295
4MP0003705_abnormal_hypodermis_morpholog3.48608964
5MP0010368_abnormal_lymphatic_system3.47823203
6MP0005275_abnormal_skin_tensile3.08517600
7MP0006054_spinal_hemorrhage2.94439367
8MP0004130_abnormal_muscle_cell2.78432227
9MP0004084_abnormal_cardiac_muscle2.74324845
10MP0005666_abnormal_adipose_tissue2.72516095
11MP0002837_dystrophic_cardiac_calcinosis2.69318997
12MP0001879_abnormal_lymphatic_vessel2.54588156
13MP0004185_abnormal_adipocyte_glucose2.45693454
14MP0005623_abnormal_meninges_morphology2.37275896
15MP0005257_abnormal_intraocular_pressure2.29274860
16MP0000751_myopathy2.28690128
17MP0008775_abnormal_heart_ventricle2.19894063
18MP0006138_congestive_heart_failure2.16451064
19MP0003279_aneurysm2.14964316
20MP0005503_abnormal_tendon_morphology2.12059086
21MP0005375_adipose_tissue_phenotype2.10753317
22MP0004215_abnormal_myocardial_fiber1.96437691
23MP0003828_pulmonary_edema1.94755952
24MP0005330_cardiomyopathy1.80265731
25MP0000013_abnormal_adipose_tissue1.79617335
26MP0001542_abnormal_bone_strength1.71737079
27MP0004036_abnormal_muscle_relaxation1.68101794
28MP0000003_abnormal_adipose_tissue1.67878208
29MP0005167_abnormal_blood-brain_barrier1.67482136
30MP0001544_abnormal_cardiovascular_syste1.57055358
31MP0005385_cardiovascular_system_phenoty1.57055358
32MP0005171_absent_coat_pigmentation1.55183575
33MP0010630_abnormal_cardiac_muscle1.52209180
34MP0001958_emphysema1.51994276
35MP0004087_abnormal_muscle_fiber1.50343473
36MP0002108_abnormal_muscle_morphology1.50182325
37MP0000750_abnormal_muscle_regeneration1.47807814
38MP0002972_abnormal_cardiac_muscle1.46563552
39* MP0003566_abnormal_cell_adhesion1.43300163
40MP0005620_abnormal_muscle_contractility1.40763300
41MP0001299_abnormal_eye_distance/1.38950453
42MP0003950_abnormal_plasma_membrane1.37702775
43MP0010329_abnormal_lipoprotein_level1.37011401
44MP0002971_abnormal_brown_adipose1.35282116
45MP0001661_extended_life_span1.31545850
46MP0002295_abnormal_pulmonary_circulatio1.30942643
47MP0004484_altered_response_of1.24056103
48MP0003942_abnormal_urinary_system1.23845836
49MP0002127_abnormal_cardiovascular_syste1.23311725
50MP0009384_cardiac_valve_regurgitation1.21629037
51MP0010030_abnormal_orbit_morphology1.18991070
52MP0003941_abnormal_skin_development1.18662627
53MP0000767_abnormal_smooth_muscle1.18330457
54MP0001915_intracranial_hemorrhage1.17796112
55MP0003646_muscle_fatigue1.15521067
56MP0009115_abnormal_fat_cell1.14896701
57MP0002332_abnormal_exercise_endurance1.13036920
58MP0002128_abnormal_blood_circulation1.07510290
59MP0004782_abnormal_surfactant_physiolog1.07451403
60MP0003045_fibrosis1.06808974
61MP0005595_abnormal_vascular_smooth1.06771074
62MP0005164_abnormal_response_to1.02544916
63MP0003091_abnormal_cell_migration1.01407305
64MP0005365_abnormal_bile_salt1.00512410
65* MP0002925_abnormal_cardiovascular_devel1.00288690
66MP0005197_abnormal_uvea_morphology0.99564450
67MP0010352_gastrointestinal_tract_polyps0.97984448
68MP0005508_abnormal_skeleton_morphology0.97264989
69MP0000749_muscle_degeneration0.97103563
70MP0001614_abnormal_blood_vessel0.96829342
71MP0003385_abnormal_body_wall0.95558167
72* MP0000266_abnormal_heart_morphology0.94835129
73MP0000759_abnormal_skeletal_muscle0.94294008
74MP0005409_darkened_coat_color0.94269056
75MP0004085_abnormal_heartbeat0.93960324
76MP0002877_abnormal_melanocyte_morpholog0.93374329
77MP0005248_abnormal_Harderian_gland0.93273234
78MP0000733_abnormal_muscle_development0.92756220
79MP0009053_abnormal_anal_canal0.91723925
80MP0009780_abnormal_chondrocyte_physiolo0.91426343
81MP0003252_abnormal_bile_duct0.90917654
82MP0000428_abnormal_craniofacial_morphol0.90804520
83MP0004233_abnormal_muscle_weight0.89949706
84MP0005187_abnormal_penis_morphology0.89199343
85MP0003137_abnormal_impulse_conducting0.88968354
86MP0000163_abnormal_cartilage_morphology0.88590350
87MP0003283_abnormal_digestive_organ0.87993238
88MP0002060_abnormal_skin_morphology0.86967697
89MP0005367_renal/urinary_system_phenotyp0.86818138
90MP0000516_abnormal_urinary_system0.86818138
91MP0005334_abnormal_fat_pad0.85327026
92MP0002269_muscular_atrophy0.85058744
93MP0005360_urolithiasis0.84498735
94MP0003868_abnormal_feces_composition0.84270769
95MP0001243_abnormal_dermal_layer0.83698409
96MP0002118_abnormal_lipid_homeostasis0.83137362
97MP0000537_abnormal_urethra_morphology0.82480311
98MP0000762_abnormal_tongue_morphology0.81896764
99MP0005023_abnormal_wound_healing0.81620808
100MP0003567_abnormal_fetal_cardiomyocyte0.80942516
101MP0002168_other_aberrant_phenotype0.80803482
102MP0005369_muscle_phenotype0.80019357
103MP0002249_abnormal_larynx_morphology0.79459931
104MP0002139_abnormal_hepatobiliary_system0.77610713
105MP0005085_abnormal_gallbladder_physiolo0.76584680
106MP0005076_abnormal_cell_differentiation0.76499220
107MP0002106_abnormal_muscle_physiology0.74235260
108MP0002133_abnormal_respiratory_system0.74233325
109MP0005388_respiratory_system_phenotype0.74233325
110MP0003115_abnormal_respiratory_system0.73885785
111MP0000534_abnormal_ureter_morphology0.73227509
112* MP0003935_abnormal_craniofacial_develop0.73076481
113MP0009250_abnormal_appendicular_skeleto0.72869785
114MP0002115_abnormal_skeleton_extremities0.72547855
115MP0002896_abnormal_bone_mineralization0.71674796
116MP0000462_abnormal_digestive_system0.71323788
117MP0001175_abnormal_lung_morphology0.70750377
118MP0002088_abnormal_embryonic_growth/wei0.70686241
119MP0002933_joint_inflammation0.70528225
120MP0002970_abnormal_white_adipose0.69949974
121MP0002932_abnormal_joint_morphology0.69746800
122MP0005165_increased_susceptibility_to0.69661281
123MP0003755_abnormal_palate_morphology0.67182267
124MP0008004_abnormal_stomach_pH0.66578371
125MP0003191_abnormal_cellular_cholesterol0.66179334
126MP0004858_abnormal_nervous_system0.65849232
127MP0000249_abnormal_blood_vessel0.63924401
128MP0005390_skeleton_phenotype0.63412659
129MP0002113_abnormal_skeleton_development0.62652998
130MP0000432_abnormal_head_morphology0.61806304
131MP0004883_abnormal_blood_vessel0.60475462
132MP0000569_abnormal_digit_pigmentation0.60006506
133MP0010386_abnormal_urinary_bladder0.59568099
134MP0009840_abnormal_foam_cell0.55937212

Predicted human phenotypes

RankGene SetZ-score
1Vascular tortuosity (HP:0004948)4.61757961
2Protrusio acetabuli (HP:0003179)4.50415121
3Broad metatarsal (HP:0001783)4.49026171
4Arterial tortuosity (HP:0005116)4.30387361
5Increased connective tissue (HP:0009025)4.01125756
6Premature rupture of membranes (HP:0001788)3.74994817
7Cerebral aneurysm (HP:0004944)3.60418869
8Shallow orbits (HP:0000586)3.56032373
9Ankle contracture (HP:0006466)3.35172519
10Wormian bones (HP:0002645)3.33670427
11Right ventricular cardiomyopathy (HP:0011663)3.25598395
12Muscle fiber splitting (HP:0003555)3.22740635
13Acanthosis nigricans (HP:0000956)3.19351277
14Neonatal short-limb short stature (HP:0008921)3.12903326
15Sudden death (HP:0001699)3.12072264
16Abnormality of dentin (HP:0010299)3.03075390
17Lymphangioma (HP:0100764)2.90293238
18Cervical subluxation (HP:0003308)2.88899635
19Hyporeflexia of lower limbs (HP:0002600)2.85952626
20Difficulty running (HP:0009046)2.77811064
21Ventricular tachycardia (HP:0004756)2.74735436
22Hypoplastic ischia (HP:0003175)2.74496902
23Spinal rigidity (HP:0003306)2.71974631
24Aortic dissection (HP:0002647)2.68736421
25Lipoatrophy (HP:0100578)2.68216008
26Spondylolisthesis (HP:0003302)2.67763193
27Pigmentary retinal degeneration (HP:0001146)2.61860284
28Aneurysm (HP:0002617)2.59833565
29Abnormality of the ischium (HP:0003174)2.58216690
30Hyperglycinuria (HP:0003108)2.56916563
31Hypoalphalipoproteinemia (HP:0003233)2.55715329
32Mitral stenosis (HP:0001718)2.55163179
33Osteolytic defects of the phalanges of the hand (HP:0009771)2.55056227
34Osteolytic defects of the hand bones (HP:0009699)2.55056227
35Increased variability in muscle fiber diameter (HP:0003557)2.54863299
36Mitral valve prolapse (HP:0001634)2.54202712
37Aortic aneurysm (HP:0004942)2.51590916
38Atrial fibrillation (HP:0005110)2.47644005
39Type 1 muscle fiber predominance (HP:0003803)2.43930476
40Deep venous thrombosis (HP:0002625)2.40919831
41Cardiovascular calcification (HP:0011915)2.38623822
42Hypoglycemic coma (HP:0001325)2.38483052
43Slender build (HP:0001533)2.34418221
44Oligomenorrhea (HP:0000876)2.33428060
45Abnormal delivery (HP:0001787)2.31683357
46Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31666474
47Abnormality of the 4th metacarpal (HP:0010012)2.31436956
48Myoglobinuria (HP:0002913)2.31006524
49Aortic valve stenosis (HP:0001650)2.29956168
50Bladder diverticulum (HP:0000015)2.29240365
51Abnormality of the acetabulum (HP:0003170)2.29158523
52Polycythemia (HP:0001901)2.26376265
53Vertebral compression fractures (HP:0002953)2.26076316
54Atrophic scars (HP:0001075)2.25323000
55Primary atrial arrhythmia (HP:0001692)2.25285072
56Supraventricular arrhythmia (HP:0005115)2.25226008
57Aortic regurgitation (HP:0001659)2.22926885
58Esophageal varix (HP:0002040)2.20109754
59Mitral regurgitation (HP:0001653)2.18662100
60Bowel diverticulosis (HP:0005222)2.17275603
61Round ear (HP:0100830)2.15547268
62Overgrowth (HP:0001548)2.10390946
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.09256870
64Short 4th metacarpal (HP:0010044)2.09256870
65Hematochezia (HP:0002573)2.08806828
66Coronal craniosynostosis (HP:0004440)2.08784640
67Venous insufficiency (HP:0005293)2.08281264
68Supraventricular tachycardia (HP:0004755)2.08245917
69Vertebral arch anomaly (HP:0008438)2.07091696
70Disproportionate tall stature (HP:0001519)2.06922705
71Soft skin (HP:0000977)2.04274081
72Complement deficiency (HP:0004431)2.04072206
73Subcapsular cataract (HP:0000523)2.03900954
74Venous abnormality (HP:0002624)2.03662498
75Elbow flexion contracture (HP:0002987)2.03642104
76Abnormality of skeletal muscle fiber size (HP:0012084)2.03552746
77Knee flexion contracture (HP:0006380)2.03263472
78Striae distensae (HP:0001065)2.01395056
79Abnormality of the anterior chamber (HP:0000593)2.01129247
80Mildly elevated creatine phosphokinase (HP:0008180)2.00485344
81Follicular hyperkeratosis (HP:0007502)1.99139328
82Abnormality of glycine metabolism (HP:0010895)1.98660050
83Abnormality of serine family amino acid metabolism (HP:0010894)1.98660050
84Hip contracture (HP:0003273)1.97319467
85Wrist flexion contracture (HP:0001239)1.97002352
86Wide anterior fontanel (HP:0000260)1.96962198
87Turricephaly (HP:0000262)1.96279938
88Hypertriglyceridemia (HP:0002155)1.95818379
89Dilatation of the ascending aorta (HP:0005111)1.95269761
90Skin nodule (HP:0200036)1.93693426
91Biconcave vertebral bodies (HP:0004586)1.93378295
92Abnormality of the calf musculature (HP:0001430)1.92763610
93Visceral angiomatosis (HP:0100761)1.91658423
94Bronchomalacia (HP:0002780)1.91398902
95Skull defect (HP:0001362)1.91101684
96Chorioretinal atrophy (HP:0000533)1.90606683
97Protruding ear (HP:0000411)1.89311397
98Blue sclerae (HP:0000592)1.88661350
99Nonimmune hydrops fetalis (HP:0001790)1.88140985
100Ulnar bowing (HP:0003031)1.86021251
101Ectopia lentis (HP:0001083)1.84459860
102Genu recurvatum (HP:0002816)1.83099269
103Peritonitis (HP:0002586)1.82891389
104Abnormality of proline metabolism (HP:0010907)1.82848216
105Hydroxyprolinuria (HP:0003080)1.82848216
106Hemorrhage of the eye (HP:0011885)1.81783841
107Hypoventilation (HP:0002791)1.81674151
108Mesangial abnormality (HP:0001966)1.81543698
109Rectal prolapse (HP:0002035)1.81401547
110Hyperextensible skin (HP:0000974)1.80729157
111Hypoplasia of the iris (HP:0007676)1.80671758
112Fragile skin (HP:0001030)1.80488246
113Camptodactyly of toe (HP:0001836)1.80088315
114Inguinal hernia (HP:0000023)1.78194981
115Vitreoretinal degeneration (HP:0000655)1.77278777
116Exercise-induced muscle cramps (HP:0003710)1.76949553
117Abnormal ossification of hand bones (HP:0005921)1.76783364
118Hemangiomatosis (HP:0007461)1.76469566
119Short nail (HP:0001799)1.76258954
120Short hallux (HP:0010109)1.76172325
121Reduced subcutaneous adipose tissue (HP:0003758)1.76100951
122Joint stiffness (HP:0001387)1.76042760
123Joint contractures involving the joints of the feet (HP:0100492)1.76032710
124Flexion contracture of toe (HP:0005830)1.76032710
125Insulin-resistant diabetes mellitus (HP:0000831)1.75600481
126Long toe (HP:0010511)1.73237255
127Mild short stature (HP:0003502)1.73214193
128Epidermoid cyst (HP:0200040)1.73110644
129Bradycardia (HP:0001662)1.73035488
130Osteoarthritis (HP:0002758)1.72859582
131Abnormality of carpal bone ossification (HP:0006257)1.72727680
132Pulmonic stenosis (HP:0001642)1.72365027
133Spinal cord lesions (HP:0100561)1.71654218
134Syringomyelia (HP:0003396)1.71654218
135Enlarged penis (HP:0000040)1.71534341
136Delayed closure of the anterior fontanelle (HP:0001476)1.70949652
137Delayed cranial suture closure (HP:0000270)1.70231584
138Hyperlipoproteinemia (HP:0010980)1.69092262
139Broad ribs (HP:0000885)1.68846052
140Abnormal cartilage morphology (HP:0002763)1.68731553
141Arachnodactyly (HP:0001166)1.68519492
142Limited hip movement (HP:0008800)1.68465548
143Difficulty climbing stairs (HP:0003551)1.68426281
144Interstitial pulmonary disease (HP:0006530)1.68339753
145Adactyly (HP:0009776)1.67067446
146Xanthomatosis (HP:0000991)1.66421209
147Ovoid vertebral bodies (HP:0003300)1.66361475
148Dilated cardiomyopathy (HP:0001644)1.65575866
149Neonatal death (HP:0003811)1.65237723
150Renal duplication (HP:0000075)1.63349948
151Mesomelia (HP:0003027)1.62949736
152Pulmonary artery stenosis (HP:0004415)1.62822032
153Joint laxity (HP:0001388)1.61332612
154Atrioventricular block (HP:0001678)1.61102859
155Asymmetry of the thorax (HP:0001555)1.61099583
156Aplasia/Hypoplasia of the hallux (HP:0008362)1.60731290
157Myocardial infarction (HP:0001658)1.59088428
158Glucose intolerance (HP:0000833)1.57912475
159Single umbilical artery (HP:0001195)1.56019983
160Abnormality of the fetal cardiovascular system (HP:0010948)1.56019983

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.59496212
2RIPK13.19721993
3CAMK1D3.11533617
4SIK12.97280414
5TRIB32.96989276
6LATS12.84764191
7KDR2.56628034
8EPHB22.43817032
9CAMK1G2.38533383
10TTN2.38345111
11PDGFRA2.37908540
12TAF12.11403122
13LATS22.11239074
14PKN22.07753953
15TGFBR22.05723150
16DDR22.02832887
17FGFR21.88998243
18TRPM71.73783650
19DMPK1.71676396
20FER1.62557965
21PDK31.62390092
22PDK41.62390092
23INSRR1.59442737
24MYLK1.56673328
25BCKDK1.54505589
26LMTK21.53414649
27LIMK11.51865947
28CDK121.48536245
29AKT31.46306141
30PDK21.41137650
31STK38L1.37773656
32TGFBR11.33691017
33PIK3CG1.31383035
34PRKAA21.21499913
35MET1.21241744
36PTK2B1.20366975
37TESK11.10919208
38PRKD31.09271848
39MTOR1.07778101
40PIK3CA1.07177489
41EPHA21.05250491
42PHKG11.04316748
43PHKG21.04316748
44NEK11.01283810
45FGFR11.00653702
46BMX0.99417085
47ERN10.99118113
48FGFR30.97812817
49OBSCN0.96344599
50MELK0.96186747
51WNK40.95027370
52PAK20.94579715
53FGFR40.92043196
54PAK30.91524037
55ZAP700.90925463
56ABL20.87446396
57PTK20.85369928
58PDGFRB0.84841520
59PTK60.83947907
60ROCK20.81176238
61STK30.80785992
62PNCK0.80291452
63CDK60.79985839
64NTRK20.79301426
65PRKAA10.77404059
66ROCK10.76973964
67CDK80.76496136
68ADRBK10.75589795
69MOS0.75386119
70GRK10.73868948
71CDK90.72618508
72ICK0.72265192
73MAP3K60.68640363
74MAP3K20.68473161
75GSK3A0.66557528
76STK380.65351938
77FRK0.64985276
78RPS6KA20.64192825
79PRKCH0.64087402
80KSR20.63213831
81MAPK150.61932051
82WNK10.61500117
83MAP3K70.60912853
84MAP2K10.59466783
85RET0.59002518
86EEF2K0.58770670
87* PRKD10.58481003
88PAK40.57724132
89MST1R0.57370058
90NTRK30.56718073
91MAP3K120.55815546
92PRKG20.55578197
93FLT30.52780274
94CAMK40.52371252
95STK390.51072812
96PRKCE0.50072870
97CDC42BPA0.50057593
98MAPK120.48560155
99TYRO30.48476063
100INSR0.48057433
101GRK70.47977851
102MAP2K30.46585333
103PAK60.45390530
104PINK10.45313252
105MARK20.45261298
106IGF1R0.44753720
107EPHB10.44363054
108PRKD20.43991964
109MAPK70.43643473
110MAP2K40.42988864
111AKT20.41830509
112GRK50.41745564
113ZAK0.40634357
114MAPKAPK30.40626751
115MAP3K30.39977620
116ERBB40.39272425
117NEK90.38317103
118SGK30.38026609
119SRC0.37720686
120KIT0.36972234
121PLK20.36938570
122CLK10.36509500
123CDK40.35777419
124PRKG10.35668111
125STK110.35355708
126PRKACG0.34919551
127CAMK2G0.34443332
128RAF10.33064752
129EPHA30.32947077
130JAK10.32130640
131DAPK30.31933928
132PDPK10.31508418
133NTRK10.30938465
134ILK0.30615088

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006402.87964302
2PPAR signaling pathway_Homo sapiens_hsa033202.80818334
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71498799
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.68326607
5Nitrogen metabolism_Homo sapiens_hsa009102.61663168
6ECM-receptor interaction_Homo sapiens_hsa045122.55620339
7Fatty acid degradation_Homo sapiens_hsa000712.52403270
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40913189
9Fatty acid metabolism_Homo sapiens_hsa012122.37580249
10Fatty acid biosynthesis_Homo sapiens_hsa000612.36224942
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.33899422
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24543865
13Dilated cardiomyopathy_Homo sapiens_hsa054141.94379870
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.78343767
15Focal adhesion_Homo sapiens_hsa045101.78036694
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.77759939
17Arginine biosynthesis_Homo sapiens_hsa002201.74398475
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67876358
19Adherens junction_Homo sapiens_hsa045201.61684210
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53402452
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47775673
22Tryptophan metabolism_Homo sapiens_hsa003801.41727373
23Carbon metabolism_Homo sapiens_hsa012001.39501129
24Lysine degradation_Homo sapiens_hsa003101.38675113
25Protein digestion and absorption_Homo sapiens_hsa049741.38408977
26AMPK signaling pathway_Homo sapiens_hsa041521.37484234
27Complement and coagulation cascades_Homo sapiens_hsa046101.36041669
28Pyruvate metabolism_Homo sapiens_hsa006201.35731510
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.35261181
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32314043
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.31510885
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.26616537
33Glycerolipid metabolism_Homo sapiens_hsa005611.24758166
34Insulin resistance_Homo sapiens_hsa049311.24531967
35beta-Alanine metabolism_Homo sapiens_hsa004101.18210285
36Butanoate metabolism_Homo sapiens_hsa006501.14537227
37Basal cell carcinoma_Homo sapiens_hsa052171.12991905
38Chronic myeloid leukemia_Homo sapiens_hsa052201.12844866
39Proteoglycans in cancer_Homo sapiens_hsa052051.11085327
40Glioma_Homo sapiens_hsa052141.10673201
41Bile secretion_Homo sapiens_hsa049761.08414714
42Gap junction_Homo sapiens_hsa045401.08262451
43Amoebiasis_Homo sapiens_hsa051461.07349973
44Hippo signaling pathway_Homo sapiens_hsa043901.05687977
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.04155599
46Small cell lung cancer_Homo sapiens_hsa052221.02379746
47Glucagon signaling pathway_Homo sapiens_hsa049221.00914885
48Caffeine metabolism_Homo sapiens_hsa002320.97820250
49TGF-beta signaling pathway_Homo sapiens_hsa043500.96930459
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96343524
51Phenylalanine metabolism_Homo sapiens_hsa003600.92899725
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91940639
53Tight junction_Homo sapiens_hsa045300.91907700
54Platelet activation_Homo sapiens_hsa046110.90676743
55Insulin signaling pathway_Homo sapiens_hsa049100.90674293
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89005509
57Fat digestion and absorption_Homo sapiens_hsa049750.86230594
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.85574095
59Tyrosine metabolism_Homo sapiens_hsa003500.83085307
60Peroxisome_Homo sapiens_hsa041460.82592067
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81257434
62Thyroid hormone synthesis_Homo sapiens_hsa049180.80830990
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80362386
64Renin secretion_Homo sapiens_hsa049240.78978761
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78697321
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77987883
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76632583
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75783838
69Rap1 signaling pathway_Homo sapiens_hsa040150.75669210
70Hedgehog signaling pathway_Homo sapiens_hsa043400.73962121
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73366298
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73068826
73Melanoma_Homo sapiens_hsa052180.73029187
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71939680
75Malaria_Homo sapiens_hsa051440.71718831
76Prostate cancer_Homo sapiens_hsa052150.71319501
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70846076
78Biosynthesis of amino acids_Homo sapiens_hsa012300.70437116
79Ras signaling pathway_Homo sapiens_hsa040140.68614072
80HIF-1 signaling pathway_Homo sapiens_hsa040660.67317206
81Dorso-ventral axis formation_Homo sapiens_hsa043200.66333610
82Viral myocarditis_Homo sapiens_hsa054160.66222156
83Histidine metabolism_Homo sapiens_hsa003400.64981190
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62765876
85GnRH signaling pathway_Homo sapiens_hsa049120.62421766
86mTOR signaling pathway_Homo sapiens_hsa041500.62320299
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62295976
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62123259
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61939350
90Pathways in cancer_Homo sapiens_hsa052000.61746969
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61597123
92Starch and sucrose metabolism_Homo sapiens_hsa005000.61406477
93MicroRNAs in cancer_Homo sapiens_hsa052060.61084944
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58846599
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58719094
96cAMP signaling pathway_Homo sapiens_hsa040240.58709626
97Pertussis_Homo sapiens_hsa051330.58323546
98N-Glycan biosynthesis_Homo sapiens_hsa005100.58313994
99Type II diabetes mellitus_Homo sapiens_hsa049300.58173643
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.55234767
101Ovarian steroidogenesis_Homo sapiens_hsa049130.55068069
102Oxytocin signaling pathway_Homo sapiens_hsa049210.54268543
103Calcium signaling pathway_Homo sapiens_hsa040200.53958080
104Inositol phosphate metabolism_Homo sapiens_hsa005620.53858558
105Pancreatic cancer_Homo sapiens_hsa052120.53477811
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52398884
107Bladder cancer_Homo sapiens_hsa052190.52239493
108Notch signaling pathway_Homo sapiens_hsa043300.51949209
109Axon guidance_Homo sapiens_hsa043600.51465295
110Cocaine addiction_Homo sapiens_hsa050300.51307096
111ErbB signaling pathway_Homo sapiens_hsa040120.51181952
112Melanogenesis_Homo sapiens_hsa049160.50826866
113Gastric acid secretion_Homo sapiens_hsa049710.50727493
114Endocytosis_Homo sapiens_hsa041440.50639960
115Cardiac muscle contraction_Homo sapiens_hsa042600.50568724
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49944210
117ABC transporters_Homo sapiens_hsa020100.49077824
118Choline metabolism in cancer_Homo sapiens_hsa052310.48894518
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.48722885
120Sphingolipid metabolism_Homo sapiens_hsa006000.44234504
121Salivary secretion_Homo sapiens_hsa049700.43998809
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43846764
123Staphylococcus aureus infection_Homo sapiens_hsa051500.43751171
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41442210
125Estrogen signaling pathway_Homo sapiens_hsa049150.40565697
126Mineral absorption_Homo sapiens_hsa049780.40375238
127Wnt signaling pathway_Homo sapiens_hsa043100.40284271
128Chemical carcinogenesis_Homo sapiens_hsa052040.40108818
129Thyroid cancer_Homo sapiens_hsa052160.39915877
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39727870
131Renin-angiotensin system_Homo sapiens_hsa046140.39340300
132MAPK signaling pathway_Homo sapiens_hsa040100.39291098
133Sulfur metabolism_Homo sapiens_hsa009200.38671894
134Fatty acid elongation_Homo sapiens_hsa000620.38378785
135Renal cell carcinoma_Homo sapiens_hsa052110.38263884
136FoxO signaling pathway_Homo sapiens_hsa040680.38240387
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.36306281
138Prion diseases_Homo sapiens_hsa050200.36174647
139Retinol metabolism_Homo sapiens_hsa008300.36086866

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