DIXDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.41890680
2central nervous system myelination (GO:0022010)7.41890680
3fatty acid elongation (GO:0030497)4.37200458
4myelination (GO:0042552)4.31058683
5axon ensheathment (GO:0008366)4.27078244
6ensheathment of neurons (GO:0007272)4.27078244
7presynaptic membrane organization (GO:0097090)4.07345010
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99971146
9synaptic vesicle maturation (GO:0016188)3.98554815
10L-amino acid import (GO:0043092)3.98027752
11negative regulation of neurotransmitter transport (GO:0051589)3.95287995
12neuron cell-cell adhesion (GO:0007158)3.94075030
13neuronal action potential propagation (GO:0019227)3.91005658
14presynaptic membrane assembly (GO:0097105)3.87740518
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.83922462
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.83066757
17long-chain fatty acid biosynthetic process (GO:0042759)3.81620733
18negative regulation of neurotransmitter secretion (GO:0046929)3.76010558
19locomotory exploration behavior (GO:0035641)3.71926101
20pyrimidine nucleobase catabolic process (GO:0006208)3.71113703
21transmission of nerve impulse (GO:0019226)3.69668486
22cerebellar granule cell differentiation (GO:0021707)3.69555544
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.62764911
24vocalization behavior (GO:0071625)3.61841081
25synaptic vesicle exocytosis (GO:0016079)3.59696638
26regulation of synaptic vesicle exocytosis (GO:2000300)3.58383503
27dendritic spine morphogenesis (GO:0060997)3.53900422
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.49392980
29protein localization to synapse (GO:0035418)3.46632588
30adult walking behavior (GO:0007628)3.45890224
31glutamate receptor signaling pathway (GO:0007215)3.41222969
32establishment of mitochondrion localization (GO:0051654)3.39553028
33postsynaptic membrane organization (GO:0001941)3.38179472
34eye photoreceptor cell differentiation (GO:0001754)3.35990432
35photoreceptor cell differentiation (GO:0046530)3.35990432
36neuron recognition (GO:0008038)3.29671656
37synaptic transmission, glutamatergic (GO:0035249)3.29012593
38neuron-neuron synaptic transmission (GO:0007270)3.28172579
39glutamate secretion (GO:0014047)3.27834050
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.23763184
41gamma-aminobutyric acid transport (GO:0015812)3.23572792
42apical protein localization (GO:0045176)3.22076226
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.20767520
44neuronal ion channel clustering (GO:0045161)3.18473335
45negative regulation of protein localization to cell surface (GO:2000009)3.18302242
46nucleobase catabolic process (GO:0046113)3.16490779
47limb bud formation (GO:0060174)3.14097271
48cellular potassium ion homeostasis (GO:0030007)3.08579811
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07297171
50regulation of glutamate receptor signaling pathway (GO:1900449)3.05494639
51regulation of neuronal synaptic plasticity (GO:0048168)3.04942234
52dendrite morphogenesis (GO:0048813)3.03577208
53axonal fasciculation (GO:0007413)3.02878078
54amino acid import (GO:0043090)3.02306209
55regulation of synaptic vesicle transport (GO:1902803)3.02171706
56layer formation in cerebral cortex (GO:0021819)3.01283071
57negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.99676653
58neuron remodeling (GO:0016322)2.98842582
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98528929
60asymmetric protein localization (GO:0008105)2.97127723
61oligodendrocyte differentiation (GO:0048709)2.96651254
62glycine transport (GO:0015816)2.95582160
63mating behavior (GO:0007617)2.93735902
64regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93148320
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92937493
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92424515
67response to methylmercury (GO:0051597)2.90631384
68myelin maintenance (GO:0043217)2.90331212
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.90065113
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89407675
71auditory behavior (GO:0031223)2.86630515
72regulation of dendritic spine morphogenesis (GO:0061001)2.86614726
73positive regulation of membrane potential (GO:0045838)2.86304010
74regulation of voltage-gated calcium channel activity (GO:1901385)2.86035518
75neurotransmitter-gated ion channel clustering (GO:0072578)2.85773609
76neurotransmitter secretion (GO:0007269)2.82210595
77long-term memory (GO:0007616)2.79897438
78response to pheromone (GO:0019236)2.79872773
79membrane hyperpolarization (GO:0060081)2.78340245
80mechanosensory behavior (GO:0007638)2.78295679
81neurotransmitter uptake (GO:0001504)2.77525563
82positive regulation of dendritic spine morphogenesis (GO:0061003)2.76907237
83glycerophospholipid catabolic process (GO:0046475)2.75905831
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75604670
85exploration behavior (GO:0035640)2.74949843
86regulation of collateral sprouting (GO:0048670)2.74353775
87regulation of postsynaptic membrane potential (GO:0060078)2.74177754
88neurotransmitter transport (GO:0006836)2.73244036
89cerebellar Purkinje cell differentiation (GO:0021702)2.70416757
90negative regulation of axonogenesis (GO:0050771)2.70088180
91peptidyl-tyrosine autophosphorylation (GO:0038083)2.66887948
92regulation of neurotransmitter secretion (GO:0046928)2.65003625
93long-term synaptic potentiation (GO:0060291)2.63673540
94import into cell (GO:0098657)2.63605290
95* cerebral cortex radially oriented cell migration (GO:0021799)2.62552247
96retinal ganglion cell axon guidance (GO:0031290)2.59816300
97potassium ion import (GO:0010107)2.59351660
98behavioral response to cocaine (GO:0048148)2.58898859
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58889878
100potassium ion homeostasis (GO:0055075)2.58801333
101synapse assembly (GO:0007416)2.56651755
102neuromuscular process controlling posture (GO:0050884)2.56608119
103dendritic spine organization (GO:0097061)2.56582454
104regulation of synaptic transmission, glutamatergic (GO:0051966)2.55174978
105regulation of dendritic spine development (GO:0060998)2.55007273
106neuromuscular process controlling balance (GO:0050885)2.54534238
107cell differentiation in hindbrain (GO:0021533)2.54005415
108axon extension (GO:0048675)2.53709468
109regulation of neurotransmitter transport (GO:0051588)2.53474137
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.53029610
111substantia nigra development (GO:0021762)2.52552811
112negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50650727
113central nervous system projection neuron axonogenesis (GO:0021952)2.50641075
114otic vesicle formation (GO:0030916)2.48674334
115positive regulation of dendritic spine development (GO:0060999)2.45426946
116appendage development (GO:0048736)2.44322219
117limb development (GO:0060173)2.44322219
118positive regulation of synapse assembly (GO:0051965)2.42171812
119regulation of synapse assembly (GO:0051963)2.38513698
120regulation of synapse structural plasticity (GO:0051823)2.36973116
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.36047893
122establishment of nucleus localization (GO:0040023)2.35491640
123cell communication by electrical coupling (GO:0010644)2.29757534
124neuromuscular synaptic transmission (GO:0007274)2.29607121
125somite development (GO:0061053)2.29585036
126positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.29105547
127spinal cord development (GO:0021510)2.28423572
128positive regulation of synapse maturation (GO:0090129)2.28413155
129membrane depolarization during action potential (GO:0086010)2.28391079
130cell migration in hindbrain (GO:0021535)2.26955564
131embryonic retina morphogenesis in camera-type eye (GO:0060059)2.25572454
132cochlea development (GO:0090102)2.23105352
133regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.22567733
134regulation of membrane repolarization (GO:0060306)2.22034053
135startle response (GO:0001964)2.20166703
136positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19989608
137membrane assembly (GO:0071709)2.18283363
138central nervous system neuron axonogenesis (GO:0021955)2.18024872
139regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.17412772
140neuron projection extension (GO:1990138)2.17208642
141cell communication involved in cardiac conduction (GO:0086065)2.16115731
142synapse organization (GO:0050808)2.15867520
143axon extension involved in axon guidance (GO:0048846)2.15623500
144neuron projection extension involved in neuron projection guidance (GO:1902284)2.15623500
145regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.15300519
146regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.14976879
147myelination in peripheral nervous system (GO:0022011)2.13839329
148peripheral nervous system axon ensheathment (GO:0032292)2.13839329
149regulation of axon guidance (GO:1902667)2.13113399
150regulation of cell communication by electrical coupling (GO:0010649)2.12953707
151innervation (GO:0060384)2.12938779
152regulation of synapse organization (GO:0050807)2.11301072
153positive regulation of potassium ion transport (GO:0043268)2.10852575
154nonmotile primary cilium assembly (GO:0035058)2.10645602
155myotube differentiation (GO:0014902)2.08881131
156artery development (GO:0060840)2.08669465
157C4-dicarboxylate transport (GO:0015740)2.08526885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19627640
2GBX2_23144817_ChIP-Seq_PC3_Human3.55752992
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77127271
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76765587
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67069171
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43137821
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43137821
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.33888258
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28759482
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28648622
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27256641
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26490437
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24748399
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23539062
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.18888543
16DROSHA_22980978_ChIP-Seq_HELA_Human2.12735091
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.10747283
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.10520244
19TAF15_26573619_Chip-Seq_HEK293_Human2.07844478
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04806775
21AR_21572438_ChIP-Seq_LNCaP_Human2.01660228
22REST_21632747_ChIP-Seq_MESCs_Mouse1.98746936
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.98286392
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93902623
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90994154
26* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89198059
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.84699115
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.81701529
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80152899
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68340484
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66802108
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61009083
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60433502
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.56941303
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.54931925
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52607737
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.50852001
38SMAD4_21799915_ChIP-Seq_A2780_Human1.50059391
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49810328
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47597677
41P300_19829295_ChIP-Seq_ESCs_Human1.46801326
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46536178
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45384463
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44011120
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.42347179
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41672746
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41601810
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37610133
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.36423633
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36376002
51ER_23166858_ChIP-Seq_MCF-7_Human1.36191332
52VDR_22108803_ChIP-Seq_LS180_Human1.32140213
53STAT3_23295773_ChIP-Seq_U87_Human1.32007972
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30839829
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29850628
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29700225
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26792483
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24833206
59* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22944714
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20019888
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18170379
62TCF4_23295773_ChIP-Seq_U87_Human1.16740786
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16386679
64FUS_26573619_Chip-Seq_HEK293_Human1.16194171
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16018582
66RNF2_27304074_Chip-Seq_NSC_Mouse1.15986139
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15885152
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15803129
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15648077
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15623288
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.15405252
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.15125517
73EWS_26573619_Chip-Seq_HEK293_Human1.14381579
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12384553
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11863786
76ZNF274_21170338_ChIP-Seq_K562_Hela1.10622038
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.10585726
78SOX9_26525672_Chip-Seq_HEART_Mouse1.10090234
79TP53_18474530_ChIP-ChIP_U2OS_Human1.09066759
80KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08643033
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08395287
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08376418
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.07722889
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.07424792
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.07339679
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07282734
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.07033955
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07018725
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06872965
90* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06063469
91AR_25329375_ChIP-Seq_VCAP_Human1.04003694
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.02779915
93TP53_16413492_ChIP-PET_HCT116_Human1.02665223
94RUNX2_22187159_ChIP-Seq_PCA_Human1.02515012
95TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02427090
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01743375
97TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01123772
98AHR_22903824_ChIP-Seq_MCF-7_Human1.00623327
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00219527
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99733506
101PRDM14_20953172_ChIP-Seq_ESCs_Human0.99375076
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.99152876
103AR_19668381_ChIP-Seq_PC3_Human0.99111161
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96975765
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95147683
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95147683
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.95108204
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94471492
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93221150
110SMAD4_21741376_ChIP-Seq_EPCs_Human0.92835934
111IGF1R_20145208_ChIP-Seq_DFB_Human0.92314040
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.90655301
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90506762
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89810933
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89810933
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89421160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.46898353
2MP0004859_abnormal_synaptic_plasticity4.41944850
3MP0004270_analgesia3.62152514
4MP0003635_abnormal_synaptic_transmissio3.17304972
5MP0000920_abnormal_myelination3.09318280
6MP0009046_muscle_twitch2.92661710
7MP0002064_seizures2.86611493
8MP0002272_abnormal_nervous_system2.83896833
9MP0009745_abnormal_behavioral_response2.81600638
10MP0001486_abnormal_startle_reflex2.81059117
11MP0005423_abnormal_somatic_nervous2.76611437
12MP0002063_abnormal_learning/memory/cond2.48196035
13MP0004885_abnormal_endolymph2.34640270
14MP0002734_abnormal_mechanical_nocicepti2.30397485
15MP0002572_abnormal_emotion/affect_behav2.29466221
16MP0003329_amyloid_beta_deposits2.25910511
17MP0000778_abnormal_nervous_system2.14623972
18MP0005551_abnormal_eye_electrophysiolog2.10935250
19MP0003690_abnormal_glial_cell2.07567826
20MP0004742_abnormal_vestibular_system2.05710408
21MP0001529_abnormal_vocalization1.96714725
22MP0001968_abnormal_touch/_nociception1.95358451
23MP0002822_catalepsy1.91831112
24MP0001440_abnormal_grooming_behavior1.89530767
25MP0004142_abnormal_muscle_tone1.81669298
26MP0008569_lethality_at_weaning1.81178544
27MP0002067_abnormal_sensory_capabilities1.79224110
28MP0001905_abnormal_dopamine_level1.74249866
29MP0005171_absent_coat_pigmentation1.72305414
30MP0002229_neurodegeneration1.67350824
31MP0001501_abnormal_sleep_pattern1.64831894
32MP0003950_abnormal_plasma_membrane1.64338849
33MP0001485_abnormal_pinna_reflex1.63240830
34MP0003634_abnormal_glial_cell1.62206262
35MP0000955_abnormal_spinal_cord1.61038483
36MP0010030_abnormal_orbit_morphology1.60706865
37MP0004924_abnormal_behavior1.58884657
38MP0005386_behavior/neurological_phenoty1.58884657
39MP0002882_abnormal_neuron_morphology1.58878196
40MP0001970_abnormal_pain_threshold1.57212307
41MP0002184_abnormal_innervation1.53372327
42MP0002102_abnormal_ear_morphology1.50493229
43MP0005409_darkened_coat_color1.49961106
44MP0002736_abnormal_nociception_after1.47254685
45MP0002733_abnormal_thermal_nociception1.47165611
46MP0003632_abnormal_nervous_system1.43707525
47MP0002066_abnormal_motor_capabilities/c1.42878963
48MP0000569_abnormal_digit_pigmentation1.42287115
49MP0002735_abnormal_chemical_nociception1.40673530
50MP0002557_abnormal_social/conspecific_i1.40661662
51MP0002638_abnormal_pupillary_reflex1.39149446
52MP0003136_yellow_coat_color1.38740907
53MP0003633_abnormal_nervous_system1.38307412
54MP0009780_abnormal_chondrocyte_physiolo1.36738906
55MP0003631_nervous_system_phenotype1.36403761
56MP0005503_abnormal_tendon_morphology1.29736218
57MP0004043_abnormal_pH_regulation1.28317018
58MP0005645_abnormal_hypothalamus_physiol1.26268643
59MP0005646_abnormal_pituitary_gland1.26239304
60MP0003283_abnormal_digestive_organ1.24549695
61MP0005410_abnormal_fertilization1.23568066
62MP0004215_abnormal_myocardial_fiber1.21157456
63MP0004811_abnormal_neuron_physiology1.21058703
64MP0001502_abnormal_circadian_rhythm1.20930218
65MP0005187_abnormal_penis_morphology1.20583996
66MP0006292_abnormal_olfactory_placode1.20160423
67MP0001963_abnormal_hearing_physiology1.19137993
68MP0004145_abnormal_muscle_electrophysio1.18921920
69MP0002234_abnormal_pharynx_morphology1.17662134
70MP0002938_white_spotting1.17476602
71MP0006072_abnormal_retinal_apoptosis1.17390527
72MP0002752_abnormal_somatic_nervous1.17269821
73MP0001984_abnormal_olfaction1.15194490
74MP0002837_dystrophic_cardiac_calcinosis1.12800901
75MP0005253_abnormal_eye_physiology1.12470201
76MP0006276_abnormal_autonomic_nervous1.10210329
77MP0002152_abnormal_brain_morphology1.09154953
78MP0001299_abnormal_eye_distance/1.08859164
79MP0000049_abnormal_middle_ear1.07664542
80MP0003937_abnormal_limbs/digits/tail_de1.06620438
81MP0001177_atelectasis1.06291173
82MP0002233_abnormal_nose_morphology1.04170230
83MP0000604_amyloidosis1.00800805
84MP0003385_abnormal_body_wall1.00233278
85MP0005195_abnormal_posterior_eye1.00040843
86MP0000749_muscle_degeneration0.97663056
87MP0000534_abnormal_ureter_morphology0.95110315
88MP0003755_abnormal_palate_morphology0.93280171
89MP0004084_abnormal_cardiac_muscle0.92662636
90MP0010368_abnormal_lymphatic_system0.92538245
91MP0001188_hyperpigmentation0.92379297
92MP0008438_abnormal_cutaneous_collagen0.92160275
93MP0003787_abnormal_imprinting0.91662572
94MP0002108_abnormal_muscle_morphology0.89322639
95MP0003890_abnormal_embryonic-extraembry0.88052242
96MP0004272_abnormal_basement_membrane0.87767487
97MP0003121_genomic_imprinting0.87502120
98MP0003942_abnormal_urinary_system0.87388424
99MP0000566_synostosis0.86124524
100MP0001293_anophthalmia0.85754064
101MP0002090_abnormal_vision0.85615464
102MP0009250_abnormal_appendicular_skeleto0.84840939
103MP0005623_abnormal_meninges_morphology0.84099073
104MP0000428_abnormal_craniofacial_morphol0.83962761
105MP0003879_abnormal_hair_cell0.83704690
106MP0005620_abnormal_muscle_contractility0.82770629
107MP0000631_abnormal_neuroendocrine_gland0.82737889
108MP0005394_taste/olfaction_phenotype0.82033796
109MP0005499_abnormal_olfactory_system0.82033796
110MP0000026_abnormal_inner_ear0.81427798
111MP0003122_maternal_imprinting0.81099844
112MP0002653_abnormal_ependyma_morphology0.79112163
113MP0002751_abnormal_autonomic_nervous0.78811272
114MP0004134_abnormal_chest_morphology0.78310697
115MP0005275_abnormal_skin_tensile0.77565227
116MP0000462_abnormal_digestive_system0.77434430
117MP0002069_abnormal_eating/drinking_beha0.76376329
118MP0010678_abnormal_skin_adnexa0.74638852
119MP0004085_abnormal_heartbeat0.73970673
120MP0002909_abnormal_adrenal_gland0.68202200
121MP0004858_abnormal_nervous_system0.66817025
122MP0003137_abnormal_impulse_conducting0.66365894
123MP0001346_abnormal_lacrimal_gland0.63512271
124MP0000013_abnormal_adipose_tissue0.63247582
125MP0003195_calcinosis0.62073554
126MP0001943_abnormal_respiration0.61456227
127MP0003938_abnormal_ear_development0.61347936
128MP0001664_abnormal_digestion0.61001988
129MP0003861_abnormal_nervous_system0.60031507
130MP0008874_decreased_physiological_sensi0.56512788
131MP0004147_increased_porphyrin_level0.56427794
132MP0000747_muscle_weakness0.55418844
133MP0000003_abnormal_adipose_tissue0.54740730
134MP0000751_myopathy0.51524504
135MP0005535_abnormal_body_temperature0.50874611
136MP0008872_abnormal_physiological_respon0.50339240

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.91085692
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.91085692
3Focal motor seizures (HP:0011153)4.88164782
4Neurofibrillary tangles (HP:0002185)4.85993234
5Myokymia (HP:0002411)4.78310597
6Abnormality of the corticospinal tract (HP:0002492)4.33304130
7Supranuclear gaze palsy (HP:0000605)3.76724020
8Focal seizures (HP:0007359)3.74811071
9Cerebral inclusion bodies (HP:0100314)3.73027779
10Action tremor (HP:0002345)3.58890783
11Scanning speech (HP:0002168)3.54549411
12Intention tremor (HP:0002080)3.50573205
13Epileptic encephalopathy (HP:0200134)3.48578397
14Dysmetria (HP:0001310)3.48126609
15Spastic gait (HP:0002064)3.30407204
16Atonic seizures (HP:0010819)3.22144661
17Insidious onset (HP:0003587)3.17767027
18Termporal pattern (HP:0011008)3.17767027
19Peripheral hypomyelination (HP:0007182)3.17417220
20Progressive cerebellar ataxia (HP:0002073)3.13170497
21Ankle clonus (HP:0011448)3.08581453
22Broad-based gait (HP:0002136)3.01431487
23Dysdiadochokinesis (HP:0002075)2.90847839
24Hyperventilation (HP:0002883)2.85818010
25Gaze-evoked nystagmus (HP:0000640)2.84583151
26Sensory axonal neuropathy (HP:0003390)2.82404636
27Onion bulb formation (HP:0003383)2.80608275
28Alacrima (HP:0000522)2.74443917
29Dialeptic seizures (HP:0011146)2.63393539
30Absence seizures (HP:0002121)2.60453416
31Visual hallucinations (HP:0002367)2.60211349
32Retinal dysplasia (HP:0007973)2.58935879
33Septo-optic dysplasia (HP:0100842)2.55473830
34Thickened helices (HP:0000391)2.47491955
35Parakeratosis (HP:0001036)2.47032840
36Megalencephaly (HP:0001355)2.47025223
37Aplasia involving bones of the upper limbs (HP:0009823)2.43898449
38Aplasia of the phalanges of the hand (HP:0009802)2.43898449
39Aplasia involving bones of the extremities (HP:0009825)2.43898449
40Abnormal auditory evoked potentials (HP:0006958)2.43856913
41Truncal ataxia (HP:0002078)2.42479064
42Generalized tonic-clonic seizures (HP:0002069)2.41100216
43Hemiparesis (HP:0001269)2.34634109
44Pheochromocytoma (HP:0002666)2.33953891
45Febrile seizures (HP:0002373)2.32497928
46Lower limb muscle weakness (HP:0007340)2.30743366
47Anxiety (HP:0000739)2.27455200
48Absent/shortened dynein arms (HP:0200106)2.24704860
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.24704860
50Decreased lacrimation (HP:0000633)2.21603227
51Urinary urgency (HP:0000012)2.19376640
52Optic nerve hypoplasia (HP:0000609)2.16043197
53Limb dystonia (HP:0002451)2.15683445
54Anteriorly placed anus (HP:0001545)2.15653590
55Increased circulating renin level (HP:0000848)2.15384605
56Blue irides (HP:0000635)2.12163342
57Congenital primary aphakia (HP:0007707)2.11721140
58Gait imbalance (HP:0002141)2.07020021
59Urinary bladder sphincter dysfunction (HP:0002839)2.06943951
60Postural instability (HP:0002172)2.06765052
61Vaginal atresia (HP:0000148)2.06260914
62Excessive salivation (HP:0003781)2.05665929
63Drooling (HP:0002307)2.05665929
64Akinesia (HP:0002304)2.04930380
65Abnormality of macular pigmentation (HP:0008002)2.03878622
66Genital tract atresia (HP:0001827)2.02510418
67Depression (HP:0000716)2.01974184
68Impaired vibration sensation in the lower limbs (HP:0002166)2.00368249
69Abnormality of the labia minora (HP:0012880)2.00333573
70Generalized myoclonic seizures (HP:0002123)1.99865805
71Nephrogenic diabetes insipidus (HP:0009806)1.99355242
72Central scotoma (HP:0000603)1.99063171
73Progressive inability to walk (HP:0002505)1.98963786
74Cutaneous finger syndactyly (HP:0010554)1.98408206
75Congenital stationary night blindness (HP:0007642)1.98104754
76Slow saccadic eye movements (HP:0000514)1.97893249
77Morphological abnormality of the pyramidal tract (HP:0002062)1.97478585
78Absent speech (HP:0001344)1.96958713
79Decreased central vision (HP:0007663)1.95830689
80Clonus (HP:0002169)1.92319761
81Clumsiness (HP:0002312)1.92155208
82Synostosis involving the elbow (HP:0003938)1.91189186
83Humeroradial synostosis (HP:0003041)1.91189186
84Poor eye contact (HP:0000817)1.90762889
85Limited hip movement (HP:0008800)1.90668343
86Abnormality of saccadic eye movements (HP:0000570)1.89897279
87Neuroendocrine neoplasm (HP:0100634)1.89807973
88Mutism (HP:0002300)1.88953609
89Exotropia (HP:0000577)1.87607717
90Spastic tetraparesis (HP:0001285)1.86736920
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85845917
92Coronal craniosynostosis (HP:0004440)1.85752850
93Abolished electroretinogram (ERG) (HP:0000550)1.85668438
94Abnormality of the calf musculature (HP:0001430)1.84827353
95Cerebral hypomyelination (HP:0006808)1.84688896
96Abnormal eating behavior (HP:0100738)1.83888393
97Torticollis (HP:0000473)1.82570763
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82308451
99Metabolic alkalosis (HP:0200114)1.82223793
100Polyphagia (HP:0002591)1.81552781
101Epileptiform EEG discharges (HP:0011182)1.81361422
102Maternal diabetes (HP:0009800)1.81057165
103Abnormal ciliary motility (HP:0012262)1.80694738
104EEG with generalized epileptiform discharges (HP:0011198)1.79709417
105Neuronal loss in central nervous system (HP:0002529)1.79235830
106Specific learning disability (HP:0001328)1.79049150
107Split foot (HP:0001839)1.78771226
108Neonatal short-limb short stature (HP:0008921)1.78751126
109Medial flaring of the eyebrow (HP:0010747)1.77979885
110Absent septum pellucidum (HP:0001331)1.76544349
111Nephronophthisis (HP:0000090)1.75568634
112Choroideremia (HP:0001139)1.75020246
113Bronchomalacia (HP:0002780)1.73806223
114Abnormal social behavior (HP:0012433)1.72798553
115Impaired social interactions (HP:0000735)1.72798553
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72779803
117Abnormality of the lower motor neuron (HP:0002366)1.71876318
118Preaxial foot polydactyly (HP:0001841)1.71665075
119Poor coordination (HP:0002370)1.71315935
120True hermaphroditism (HP:0010459)1.70185388
121Rimmed vacuoles (HP:0003805)1.68847532
122Abnormality of the ischium (HP:0003174)1.66776100
123Aortic aneurysm (HP:0004942)1.65541927
124Vascular tortuosity (HP:0004948)1.64354552
125Vitreoretinal degeneration (HP:0000655)1.64079450
126Sleep apnea (HP:0010535)1.64076150
127Cutaneous syndactyly (HP:0012725)1.63842497
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63240694
129Short 4th metacarpal (HP:0010044)1.63240694
130Hepatoblastoma (HP:0002884)1.62648399
131Type II lissencephaly (HP:0007260)1.62393720
132Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62240173
133Shallow orbits (HP:0000586)1.59314752
134Arterial tortuosity (HP:0005116)1.57684838
135Neoplasm of the heart (HP:0100544)1.57014557
136Intestinal atresia (HP:0011100)1.56909080
137Soft skin (HP:0000977)1.55040647
138Broad metatarsal (HP:0001783)1.53409018
139Prolonged QT interval (HP:0001657)1.52141020
140Abnormality of the renal medulla (HP:0100957)1.51105164
141Postaxial hand polydactyly (HP:0001162)1.50550001
142Tracheomalacia (HP:0002779)1.50480529
143Short foot (HP:0001773)1.50470899
144Midline defect of the nose (HP:0004122)1.48442982
145Chronic hepatic failure (HP:0100626)1.47086152
146Wide anterior fontanel (HP:0000260)1.44792711
147Hip contracture (HP:0003273)1.44552464
148Anophthalmia (HP:0000528)1.42767681
149Increased corneal curvature (HP:0100692)1.42312303
150Keratoconus (HP:0000563)1.42312303
151Hypoplastic ischia (HP:0003175)1.42127823
152Protrusio acetabuli (HP:0003179)1.41948110
153Atrial fibrillation (HP:0005110)1.41819139
154Calf muscle hypertrophy (HP:0008981)1.41551014
155Pancreatic fibrosis (HP:0100732)1.41426858
156Abnormality of the aortic arch (HP:0012303)1.40914905
157Left ventricular hypertrophy (HP:0001712)1.40691476
158Hip dysplasia (HP:0001385)1.40681202
159Prominent supraorbital ridges (HP:0000336)1.40189577
160Abnormality of the diencephalon (HP:0010662)1.39678380
161Turricephaly (HP:0000262)1.38920952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.14919068
2OXSR13.40672485
3EPHA43.02160309
4NTRK32.56540021
5MARK12.43291334
6CASK2.22771331
7BCR2.13498022
8CDK192.13152669
9TNIK2.11249965
10PAK62.06296792
11PNCK1.97870126
12FGFR21.90982697
13PKN11.86817935
14NTRK11.84128556
15WNK11.79858048
16PRPF4B1.79646229
17UHMK11.78019521
18MAP3K91.76541570
19MAP3K41.73497915
20EPHB21.72575186
21MAPKAPK51.70210116
22OBSCN1.67261911
23WNK41.66510178
24EPHB11.62153870
25NTRK21.51584352
26LATS21.47178046
27CAMK2B1.46663705
28DAPK21.46232330
29SGK4941.43480246
30SGK2231.43480246
31MINK11.38736511
32NEK61.36643143
33LATS11.35809727
34MAP2K71.31279263
35PRKD31.30103313
36STK38L1.27887204
37CSNK1A1L1.26981314
38* CDK51.25378792
39PBK1.23273840
40CSNK1G21.23000755
41CSNK1G31.22862571
42CAMK2D1.20902620
43FRK1.17417284
44TYRO31.16835056
45AKT31.13421882
46CCNB11.12461150
47MAPK131.12123726
48KSR21.11826215
49MET1.11641066
50ROCK21.11313214
51CAMK2A1.11119342
52TIE11.08680057
53DMPK1.07557990
54ERBB31.06421410
55SGK21.02740519
56PHKG21.02396574
57PHKG11.02396574
58PAK31.02341760
59PIK3CA0.96983278
60EPHA30.95096168
61ICK0.94808147
62PINK10.93493770
63CAMK2G0.93414373
64MARK20.93324422
65FGR0.92615133
66CSNK1G10.92559207
67MAP2K40.92062570
68CDK140.90849120
69CDK150.87373295
70PLK20.86509427
71CDK180.85478771
72ARAF0.83758343
73PDGFRA0.83490913
74PRKCH0.83075820
75MYLK0.81976192
76LIMK10.81431608
77KSR10.77638595
78PRKCG0.77436623
79STK110.77390289
80GRK50.77193342
81CAMK1G0.76520755
82CDK11A0.75246579
83PRKCE0.73656065
84MUSK0.68995104
85FES0.68550267
86ROCK10.68388371
87TGFBR20.67833881
88DYRK1A0.67797829
89CAMK40.67739902
90WNK30.65811833
91CAMKK10.63000406
92MAP3K130.62594317
93PDPK10.62124479
94MAP3K60.59989094
95DDR20.58776798
96DYRK20.58433157
97MAP3K20.58371741
98SGK10.58122243
99FYN0.57405954
100BMPR20.57328107
101INSRR0.57285649
102FGFR10.56331999
103PRKG10.55245872
104SIK20.55179308
105CAMKK20.54918682
106SGK30.54509330
107PTK2B0.53794165
108PRKCQ0.53626643
109PRKAA10.53449689
110MAP4K20.53283219
111IRAK20.53204142
112TRIM280.51924327
113CAMK10.51288097
114BMPR1B0.51142544
115ERBB20.50599952
116RIPK40.50296928
117PRKD10.48403519
118MAPK150.48191758
119CLK10.47443600
120STK380.47184883
121PRKACA0.47151216
122CAMK1D0.46908231
123RET0.45215119
124PDK10.44852182
125CSNK1E0.43772284
126CSNK1D0.43637899
127PRKACB0.43536174
128CSNK1A10.41963902
129MAPK100.41370671
130RPS6KA30.40337091
131PRKCZ0.40294654

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.96277939
2GABAergic synapse_Homo sapiens_hsa047272.64445237
3Glutamatergic synapse_Homo sapiens_hsa047242.50068251
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.49064562
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39710888
6Morphine addiction_Homo sapiens_hsa050322.26920349
7Phototransduction_Homo sapiens_hsa047442.25984754
8Synaptic vesicle cycle_Homo sapiens_hsa047212.25768043
9Circadian entrainment_Homo sapiens_hsa047132.23546957
10Fatty acid elongation_Homo sapiens_hsa000621.94177346
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90817882
12Olfactory transduction_Homo sapiens_hsa047401.84763738
13Salivary secretion_Homo sapiens_hsa049701.82334376
14Steroid biosynthesis_Homo sapiens_hsa001001.81508893
15Serotonergic synapse_Homo sapiens_hsa047261.80732861
16Long-term potentiation_Homo sapiens_hsa047201.80244928
17Nitrogen metabolism_Homo sapiens_hsa009101.78688550
18Amphetamine addiction_Homo sapiens_hsa050311.75114659
19Long-term depression_Homo sapiens_hsa047301.74140086
20Dopaminergic synapse_Homo sapiens_hsa047281.73797330
21Axon guidance_Homo sapiens_hsa043601.65923162
22Cholinergic synapse_Homo sapiens_hsa047251.57744409
23Gastric acid secretion_Homo sapiens_hsa049711.55301963
24Cocaine addiction_Homo sapiens_hsa050301.53952997
25Taste transduction_Homo sapiens_hsa047421.52813554
26Ether lipid metabolism_Homo sapiens_hsa005651.50253212
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48939099
28Insulin secretion_Homo sapiens_hsa049111.48853329
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41252799
30Renin secretion_Homo sapiens_hsa049241.39890050
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37959018
32Propanoate metabolism_Homo sapiens_hsa006401.28830230
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28618822
34ECM-receptor interaction_Homo sapiens_hsa045121.27469434
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26079769
36Basal cell carcinoma_Homo sapiens_hsa052171.25503515
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24204266
38Hippo signaling pathway_Homo sapiens_hsa043901.22868826
39Circadian rhythm_Homo sapiens_hsa047101.22624966
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21347222
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20896330
42Collecting duct acid secretion_Homo sapiens_hsa049661.15728002
43Oxytocin signaling pathway_Homo sapiens_hsa049211.13851950
44Calcium signaling pathway_Homo sapiens_hsa040201.12890406
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11034253
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09727497
47Pancreatic secretion_Homo sapiens_hsa049721.06145056
48cAMP signaling pathway_Homo sapiens_hsa040241.04840710
49Gap junction_Homo sapiens_hsa045401.02925295
50Sulfur metabolism_Homo sapiens_hsa009201.02866557
51Butanoate metabolism_Homo sapiens_hsa006501.00047675
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97845083
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96468737
54Vibrio cholerae infection_Homo sapiens_hsa051100.94424911
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.94046330
56Cardiac muscle contraction_Homo sapiens_hsa042600.92233938
57ErbB signaling pathway_Homo sapiens_hsa040120.91883899
58beta-Alanine metabolism_Homo sapiens_hsa004100.91216452
59Dorso-ventral axis formation_Homo sapiens_hsa043200.89348992
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88703356
61GnRH signaling pathway_Homo sapiens_hsa049120.87155488
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87132084
63Renal cell carcinoma_Homo sapiens_hsa052110.85440921
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.80965182
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80871118
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80011032
67Melanogenesis_Homo sapiens_hsa049160.78240274
68Protein digestion and absorption_Homo sapiens_hsa049740.77658605
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77407021
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77325589
71Adherens junction_Homo sapiens_hsa045200.76642574
72Sphingolipid metabolism_Homo sapiens_hsa006000.75781887
73TGF-beta signaling pathway_Homo sapiens_hsa043500.75439343
74Type II diabetes mellitus_Homo sapiens_hsa049300.74145544
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72127452
76Tryptophan metabolism_Homo sapiens_hsa003800.71641712
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71271848
78Ras signaling pathway_Homo sapiens_hsa040140.70677836
79Ovarian steroidogenesis_Homo sapiens_hsa049130.69849960
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69083454
81Alzheimers disease_Homo sapiens_hsa050100.66582160
82Fatty acid metabolism_Homo sapiens_hsa012120.66123759
83Oocyte meiosis_Homo sapiens_hsa041140.65829242
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.64784910
85Estrogen signaling pathway_Homo sapiens_hsa049150.64573412
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64477583
87Oxidative phosphorylation_Homo sapiens_hsa001900.63351347
88PPAR signaling pathway_Homo sapiens_hsa033200.62786811
89Focal adhesion_Homo sapiens_hsa045100.62618529
90Phenylalanine metabolism_Homo sapiens_hsa003600.62232403
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.62179935
92Choline metabolism in cancer_Homo sapiens_hsa052310.62059543
93Histidine metabolism_Homo sapiens_hsa003400.61611291
94Fatty acid degradation_Homo sapiens_hsa000710.60911267
95Glucagon signaling pathway_Homo sapiens_hsa049220.59539794
96Thyroid hormone synthesis_Homo sapiens_hsa049180.59350989
97Pyruvate metabolism_Homo sapiens_hsa006200.58744599
98Tight junction_Homo sapiens_hsa045300.58332717
99Vitamin B6 metabolism_Homo sapiens_hsa007500.56818201
100AMPK signaling pathway_Homo sapiens_hsa041520.55682413
101Bile secretion_Homo sapiens_hsa049760.54183173
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53363617
103MAPK signaling pathway_Homo sapiens_hsa040100.53245759
104Endocytosis_Homo sapiens_hsa041440.52523987
105ABC transporters_Homo sapiens_hsa020100.52239336
106Dilated cardiomyopathy_Homo sapiens_hsa054140.51872495
107Maturity onset diabetes of the young_Homo sapiens_hsa049500.51761643
108Linoleic acid metabolism_Homo sapiens_hsa005910.50761588
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50415888
110Glycerolipid metabolism_Homo sapiens_hsa005610.49706524
111Arginine biosynthesis_Homo sapiens_hsa002200.49187468
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.48986094
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47945066
114Mineral absorption_Homo sapiens_hsa049780.46846687
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45882297
116Inositol phosphate metabolism_Homo sapiens_hsa005620.45496519
117Glioma_Homo sapiens_hsa052140.45364914
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45105761
119Tyrosine metabolism_Homo sapiens_hsa003500.45074159
120Hedgehog signaling pathway_Homo sapiens_hsa043400.44991368
121Alcoholism_Homo sapiens_hsa050340.44093379
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44010575
123Fatty acid biosynthesis_Homo sapiens_hsa000610.43398195
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42020399
125Wnt signaling pathway_Homo sapiens_hsa043100.39549456
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36328224
127Rap1 signaling pathway_Homo sapiens_hsa040150.36305941
128Parkinsons disease_Homo sapiens_hsa050120.34058135
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33496117
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32741976
131Arginine and proline metabolism_Homo sapiens_hsa003300.30801294
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30201956

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