DIS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.86958521
2nuclear pore organization (GO:0006999)5.85603250
3DNA unwinding involved in DNA replication (GO:0006268)5.11759662
4protein localization to kinetochore (GO:0034501)4.79582378
5mitotic nuclear envelope disassembly (GO:0007077)4.62488952
6monoubiquitinated protein deubiquitination (GO:0035520)4.61339731
7meiotic chromosome segregation (GO:0045132)4.51726676
8folic acid-containing compound biosynthetic process (GO:0009396)4.46627434
9DNA replication initiation (GO:0006270)4.44373492
10DNA replication-dependent nucleosome organization (GO:0034723)4.41166726
11DNA replication-dependent nucleosome assembly (GO:0006335)4.41166726
12pore complex assembly (GO:0046931)4.34454880
13nuclear envelope disassembly (GO:0051081)4.33518313
14membrane disassembly (GO:0030397)4.33518313
15regulation of DNA endoreduplication (GO:0032875)4.27250970
16DNA strand elongation involved in DNA replication (GO:0006271)4.12782617
17mitotic metaphase plate congression (GO:0007080)4.11030919
18IMP biosynthetic process (GO:0006188)4.08029236
19protein localization to chromosome, centromeric region (GO:0071459)4.05615764
20nucleobase biosynthetic process (GO:0046112)3.98943769
21mitotic sister chromatid cohesion (GO:0007064)3.92648967
22DNA strand elongation (GO:0022616)3.92463883
23ribosome assembly (GO:0042255)3.84467689
24sister chromatid cohesion (GO:0007062)3.80323168
25cytoplasmic mRNA processing body assembly (GO:0033962)3.78111964
26DNA duplex unwinding (GO:0032508)3.77698504
27DNA geometric change (GO:0032392)3.76601166
28double-strand break repair via nonhomologous end joining (GO:0006303)3.75366729
29non-recombinational repair (GO:0000726)3.75366729
30regulation of spindle organization (GO:0090224)3.72439635
31metaphase plate congression (GO:0051310)3.68718616
32DNA replication checkpoint (GO:0000076)3.68435408
33mitotic chromosome condensation (GO:0007076)3.67972598
34formation of translation preinitiation complex (GO:0001731)3.65805379
35mitotic sister chromatid segregation (GO:0000070)3.65616944
36maturation of SSU-rRNA (GO:0030490)3.64934373
37heterochromatin organization (GO:0070828)3.64305280
38purine nucleobase biosynthetic process (GO:0009113)3.62874657
39sister chromatid segregation (GO:0000819)3.62056975
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61690460
41IMP metabolic process (GO:0046040)3.61570337
42DNA topological change (GO:0006265)3.61112952
43regulation of histone H3-K9 methylation (GO:0051570)3.59712640
44telomere maintenance via semi-conservative replication (GO:0032201)3.54795906
45regulation of RNA export from nucleus (GO:0046831)3.48130610
46pre-miRNA processing (GO:0031054)3.46928059
47chromatin remodeling at centromere (GO:0031055)3.45822475
48ribosome biogenesis (GO:0042254)3.45490937
49regulation of mitotic spindle organization (GO:0060236)3.44291355
50kinetochore organization (GO:0051383)3.42099133
51regulation of posttranscriptional gene silencing (GO:0060147)3.40471866
52regulation of gene silencing by miRNA (GO:0060964)3.40471866
53regulation of gene silencing by RNA (GO:0060966)3.40471866
54positive regulation of chromosome segregation (GO:0051984)3.37360228
55nuclear envelope organization (GO:0006998)3.36449816
56regulation of translational fidelity (GO:0006450)3.36022321
57DNA synthesis involved in DNA repair (GO:0000731)3.33531088
58DNA double-strand break processing (GO:0000729)3.32755902
59mitotic recombination (GO:0006312)3.31865116
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31638823
61regulation of translational termination (GO:0006449)3.31633707
62regulation of centrosome cycle (GO:0046605)3.30352793
63CENP-A containing nucleosome assembly (GO:0034080)3.29918881
64regulation of DNA damage checkpoint (GO:2000001)3.29469265
65negative regulation of histone methylation (GO:0031061)3.29226674
66DNA replication-independent nucleosome assembly (GO:0006336)3.28012802
67DNA replication-independent nucleosome organization (GO:0034724)3.28012802
68regulation of mitotic sister chromatid separation (GO:0010965)3.27108661
69regulation of mitotic sister chromatid segregation (GO:0033047)3.27108661
70regulation of sister chromatid segregation (GO:0033045)3.27108661
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26195229
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.26195229
73telomere maintenance via recombination (GO:0000722)3.26034276
74attachment of spindle microtubules to kinetochore (GO:0008608)3.23905372
75negative regulation of DNA repair (GO:0045738)3.21689134
76regulation of centrosome duplication (GO:0010824)3.21480166
77regulation of helicase activity (GO:0051095)3.19665530
78chromatin assembly or disassembly (GO:0006333)3.18371210
79establishment of chromosome localization (GO:0051303)3.17575973
80regulation of centriole replication (GO:0046599)3.15692061
81chromatin assembly (GO:0031497)3.15288033
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14329208
83regulation of chromosome segregation (GO:0051983)3.13997240
84paraxial mesoderm development (GO:0048339)3.13127711
85protein localization to chromosome (GO:0034502)3.11129389
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10602592
87DNA conformation change (GO:0071103)3.10358434
88ribonucleoprotein complex biogenesis (GO:0022613)3.10190357
89histone exchange (GO:0043486)3.08655680
90protein K6-linked ubiquitination (GO:0085020)3.08085276
91ribosomal large subunit biogenesis (GO:0042273)3.07914667
92negative regulation of chromosome segregation (GO:0051985)3.06810992
93UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06758035
94spindle checkpoint (GO:0031577)3.06581007
95protein K11-linked deubiquitination (GO:0035871)3.06328308
96response to X-ray (GO:0010165)3.04736016
97telomere maintenance via telomere lengthening (GO:0010833)3.04017240
98mitochondrial RNA metabolic process (GO:0000959)3.02693406
99dosage compensation (GO:0007549)3.01583298
100regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01289678
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01053198
102negative regulation of sister chromatid segregation (GO:0033046)3.01053198
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.01053198
104negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01053198
105spindle assembly checkpoint (GO:0071173)3.00679226
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.99169349
107mitotic spindle checkpoint (GO:0071174)2.98632571
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96855484
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96855484
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.96855484
111mitotic G2/M transition checkpoint (GO:0044818)2.96493001
112mitotic spindle assembly checkpoint (GO:0007094)2.96003300
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.95886719
114translesion synthesis (GO:0019985)2.95849244
115mRNA transport (GO:0051028)2.95372263
116spliceosomal snRNP assembly (GO:0000387)2.94829775
117regulation of nucleobase-containing compound transport (GO:0032239)2.94396160
118regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93097259
119regulation of sister chromatid cohesion (GO:0007063)2.92658824
120chaperone-mediated protein complex assembly (GO:0051131)2.90490633
121negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90458199
122microtubule anchoring (GO:0034453)2.89777428
123ATP-dependent chromatin remodeling (GO:0043044)2.88814430
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.88809803
125snRNA transcription (GO:0009301)2.87298099
126protein K48-linked deubiquitination (GO:0071108)2.87266890
127interkinetic nuclear migration (GO:0022027)2.86245000
128DNA packaging (GO:0006323)2.85117415
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.84879711
130somatic diversification of immunoglobulins (GO:0016445)2.84663926
131positive regulation of cell cycle checkpoint (GO:1901978)2.83374617

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.91967080
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.89649814
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.29212845
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09941326
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.24268763
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23557450
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15929879
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.85104226
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82243849
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56653564
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52155822
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48466061
13AR_21909140_ChIP-Seq_LNCAP_Human2.42702233
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42550654
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.26161250
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.25395952
17EWS_26573619_Chip-Seq_HEK293_Human2.22890881
18FUS_26573619_Chip-Seq_HEK293_Human2.22177305
19* XRN2_22483619_ChIP-Seq_HELA_Human2.17208300
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.13450245
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07921409
22* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06749442
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06663780
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04136313
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01373879
26* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01118015
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.00460220
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97561534
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90652232
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87936681
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85927178
32MYC_22102868_ChIP-Seq_BL_Human1.83478920
33VDR_23849224_ChIP-Seq_CD4+_Human1.82481002
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79927975
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.79368794
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72584806
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71899841
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69767332
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67938277
40TAF15_26573619_Chip-Seq_HEK293_Human1.67327269
41FOXP3_21729870_ChIP-Seq_TREG_Human1.65939947
42* TTF2_22483619_ChIP-Seq_HELA_Human1.64831375
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61377312
44DCP1A_22483619_ChIP-Seq_HELA_Human1.59621669
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58880200
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58569765
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57340821
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56398436
49GABP_19822575_ChIP-Seq_HepG2_Human1.51856418
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51099854
51ELK1_19687146_ChIP-ChIP_HELA_Human1.50992600
52KDM5A_27292631_Chip-Seq_BREAST_Human1.49225630
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.48764971
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44221080
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44125582
56CIITA_25753668_ChIP-Seq_RAJI_Human1.42098030
57IGF1R_20145208_ChIP-Seq_DFB_Human1.39711306
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38035498
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35982533
60KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34125674
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34125674
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34125674
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33495252
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32502445
65* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30500489
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27665596
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26833448
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26647499
69* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22827715
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.22595571
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21121177
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20521984
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20450494
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18359875
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17803444
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17693387
77PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17589645
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16969941
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16895630
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15945816
81* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15091667
82TFEB_21752829_ChIP-Seq_HELA_Human1.12943160
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12025446
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10548088
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10027614
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09863292
87ZNF274_21170338_ChIP-Seq_K562_Hela1.09529004
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09474460
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08597297
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.08166737
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07517777
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07175597
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06838517
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06000076
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05366646
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04329602
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02250965
98IRF1_19129219_ChIP-ChIP_H3396_Human1.01906662
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01891414
100TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01643185
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00235323
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99758147
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99519207
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98796061
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97756224
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97698804
107ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97460530
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97250731
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.92452347
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.92307962
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91175891
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.91004139
113ER_23166858_ChIP-Seq_MCF-7_Human0.89494414
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89123292
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86840754
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86596391
117CHD1_26751641_Chip-Seq_LNCaP_Human0.86517007
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85502851
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85272316
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85217147
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84917494
122MYC_18940864_ChIP-ChIP_HL60_Human0.84410492
123ZNF263_19887448_ChIP-Seq_K562_Human0.83426279
124VDR_21846776_ChIP-Seq_THP-1_Human0.83206395
125BRD4_25478319_ChIP-Seq_HGPS_Human0.82055911
126STAT3_23295773_ChIP-Seq_U87_Human0.81866772
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80674310
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78967372
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.77456574
130CBP_20019798_ChIP-Seq_JUKART_Human0.75706996
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75706996
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75391236
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74503438
134SOX17_20123909_ChIP-Seq_XEN_Mouse0.73339029
135P300_19829295_ChIP-Seq_ESCs_Human0.72250848
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.72224359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.38790928
2MP0010094_abnormal_chromosome_stability4.32260825
3MP0003111_abnormal_nucleus_morphology4.06293722
4MP0004957_abnormal_blastocyst_morpholog4.04045240
5MP0008057_abnormal_DNA_replication3.88705135
6MP0003077_abnormal_cell_cycle3.59490709
7MP0002009_preneoplasia3.21708980
8MP0010352_gastrointestinal_tract_polyps3.02220614
9MP0008058_abnormal_DNA_repair2.83212010
10MP0008007_abnormal_cellular_replicative2.60584162
11MP0001730_embryonic_growth_arrest2.58667176
12MP0003123_paternal_imprinting2.51767257
13MP0008932_abnormal_embryonic_tissue2.41563394
14MP0010307_abnormal_tumor_latency2.40867535
15MP0000350_abnormal_cell_proliferation2.38913702
16MP0000569_abnormal_digit_pigmentation2.31125241
17MP0008877_abnormal_DNA_methylation2.07967683
18MP0003705_abnormal_hypodermis_morpholog2.07953804
19MP0005076_abnormal_cell_differentiation2.06431260
20MP0001672_abnormal_embryogenesis/_devel2.03632862
21MP0005380_embryogenesis_phenotype2.03632862
22MP0004197_abnormal_fetal_growth/weight/1.95852126
23MP0009697_abnormal_copulation1.95426475
24MP0001697_abnormal_embryo_size1.93168714
25MP0002084_abnormal_developmental_patter1.92913028
26MP0003984_embryonic_growth_retardation1.86730243
27MP0002085_abnormal_embryonic_tissue1.85478342
28MP0002396_abnormal_hematopoietic_system1.84169822
29MP0002088_abnormal_embryonic_growth/wei1.83389330
30MP0003786_premature_aging1.76892269
31MP0002086_abnormal_extraembryonic_tissu1.76415709
32MP0002080_prenatal_lethality1.71105022
33MP0003890_abnormal_embryonic-extraembry1.70797164
34MP0003121_genomic_imprinting1.67404283
35MP0000537_abnormal_urethra_morphology1.61486169
36MP0009053_abnormal_anal_canal1.60447529
37MP0010030_abnormal_orbit_morphology1.58969396
38MP0001293_anophthalmia1.56963575
39MP0002653_abnormal_ependyma_morphology1.55498598
40MP0003567_abnormal_fetal_cardiomyocyte1.41831780
41MP0000490_abnormal_crypts_of1.33581526
42MP0004808_abnormal_hematopoietic_stem1.31861089
43MP0003119_abnormal_digestive_system1.29481436
44MP0000313_abnormal_cell_death1.28841287
45MP0003941_abnormal_skin_development1.27715178
46MP0010678_abnormal_skin_adnexa1.27516887
47MP0002210_abnormal_sex_determination1.26073763
48MP0002006_tumorigenesis1.21577453
49MP0000383_abnormal_hair_follicle1.20999699
50MP0000427_abnormal_hair_cycle1.19815948
51MP0003566_abnormal_cell_adhesion1.19483589
52MP0005187_abnormal_penis_morphology1.19451846
53MP0002166_altered_tumor_susceptibility1.18623803
54MP0002019_abnormal_tumor_incidence1.18432009
55MP0003937_abnormal_limbs/digits/tail_de1.16612132
56MP0001145_abnormal_male_reproductive1.12651351
57MP0009672_abnormal_birth_weight1.10377812
58MP0000428_abnormal_craniofacial_morphol1.10230416
59MP0004185_abnormal_adipocyte_glucose1.06270671
60MP0002111_abnormal_tail_morphology1.04253705
61MP0009703_decreased_birth_body1.04142701
62MP0000733_abnormal_muscle_development1.02350245
63MP0008961_abnormal_basal_metabolism1.02038257
64MP0001929_abnormal_gametogenesis1.01252603
65MP0005623_abnormal_meninges_morphology1.01184586
66MP0001915_intracranial_hemorrhage1.00876066
67MP0003718_maternal_effect0.99702166
68MP0002092_abnormal_eye_morphology0.96991429
69MP0006072_abnormal_retinal_apoptosis0.96720517
70MP0005023_abnormal_wound_healing0.94229519
71MP0002234_abnormal_pharynx_morphology0.93330783
72MP0002282_abnormal_trachea_morphology0.92546061
73MP0000653_abnormal_sex_gland0.91940365
74MP0000432_abnormal_head_morphology0.91911195
75MP0002877_abnormal_melanocyte_morpholog0.91201998
76MP0006054_spinal_hemorrhage0.91195779
77MP0003950_abnormal_plasma_membrane0.88344045
78MP0001849_ear_inflammation0.86299934
79MP0000703_abnormal_thymus_morphology0.85921266
80MP0002697_abnormal_eye_size0.85564203
81MP0001286_abnormal_eye_development0.85093892
82MP0003787_abnormal_imprinting0.83750304
83MP0003943_abnormal_hepatobiliary_system0.83688939
84MP0003806_abnormal_nucleotide_metabolis0.81781404
85MP0006035_abnormal_mitochondrial_morpho0.81584538
86MP0005266_abnormal_metabolism0.80467106
87MP0002925_abnormal_cardiovascular_devel0.80330487
88MP0004133_heterotaxia0.80325118
89MP0003935_abnormal_craniofacial_develop0.80258665
90MP0003115_abnormal_respiratory_system0.79575742
91MP0000371_diluted_coat_color0.79270304
92MP0001661_extended_life_span0.79053845
93MP0001191_abnormal_skin_condition0.77598122
94MP0005621_abnormal_cell_physiology0.77590499
95MP0005384_cellular_phenotype0.77366309
96MP0003385_abnormal_body_wall0.77091847
97MP0004233_abnormal_muscle_weight0.75156444
98MP0003861_abnormal_nervous_system0.74273831
99MP0003195_calcinosis0.73989823
100MP0003315_abnormal_perineum_morphology0.73764535
101MP0001545_abnormal_hematopoietic_system0.72061515
102MP0005397_hematopoietic_system_phenotyp0.72061515
103MP0005220_abnormal_exocrine_pancreas0.72052945
104MP0005253_abnormal_eye_physiology0.71142522
105MP0003755_abnormal_palate_morphology0.70668135
106MP0004264_abnormal_extraembryonic_tissu0.70589645
107MP0003656_abnormal_erythrocyte_physiolo0.69815549
108MP0008770_decreased_survivor_rate0.69559813
109MP0010234_abnormal_vibrissa_follicle0.69010886
110MP0005310_abnormal_salivary_gland0.68531331
111MP0003221_abnormal_cardiomyocyte_apopto0.67544225
112MP0005391_vision/eye_phenotype0.67287272
113MP0002177_abnormal_outer_ear0.66959423
114MP0001879_abnormal_lymphatic_vessel0.66757482
115MP0000358_abnormal_cell_content/0.66040646
116MP0000015_abnormal_ear_pigmentation0.65907350
117MP0002114_abnormal_axial_skeleton0.64112998
118MP0002160_abnormal_reproductive_system0.63992204
119MP0009333_abnormal_splenocyte_physiolog0.62599408
120MP0000477_abnormal_intestine_morphology0.62076508
121MP0002932_abnormal_joint_morphology0.60796989
122MP0003283_abnormal_digestive_organ0.59731371
123MP0001119_abnormal_female_reproductive0.59104374
124MP0002722_abnormal_immune_system0.58907403
125MP0003868_abnormal_feces_composition0.58831394
126MP0000266_abnormal_heart_morphology0.58714813
127MP0003763_abnormal_thymus_physiology0.58467693
128MP0003936_abnormal_reproductive_system0.58425895
129MP0004782_abnormal_surfactant_physiolog0.58062995
130MP0002075_abnormal_coat/hair_pigmentati0.57596263
131MP0001727_abnormal_embryo_implantation0.57480903
132MP0001216_abnormal_epidermal_layer0.57442917
133MP0002095_abnormal_skin_pigmentation0.57398483
134MP0003698_abnormal_male_reproductive0.57298773
135MP0000858_altered_metastatic_potential0.57280983
136MP0002398_abnormal_bone_marrow0.56874504
137MP0005389_reproductive_system_phenotype0.56824961
138MP0001186_pigmentation_phenotype0.56371848
139MP0005645_abnormal_hypothalamus_physiol0.56043363

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.00734335
2Birth length less than 3rd percentile (HP:0003561)3.79737751
3Selective tooth agenesis (HP:0001592)3.68200236
4Medulloblastoma (HP:0002885)3.58505766
5Colon cancer (HP:0003003)3.38420596
6Chromsome breakage (HP:0040012)3.24291090
7Deviation of the thumb (HP:0009603)3.09264458
8Abnormality of the labia minora (HP:0012880)3.07238298
9Proximal placement of thumb (HP:0009623)3.06097326
10Breast hypoplasia (HP:0003187)3.04872281
11Abnormality of the astrocytes (HP:0100707)3.01435019
12Astrocytoma (HP:0009592)3.01435019
13Rhabdomyosarcoma (HP:0002859)2.98906621
14Poikiloderma (HP:0001029)2.92091819
15Impulsivity (HP:0100710)2.90950331
16Papillary thyroid carcinoma (HP:0002895)2.88481869
17Reticulocytopenia (HP:0001896)2.87176580
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84852089
19Abnormality of chromosome stability (HP:0003220)2.83877219
20Acute myeloid leukemia (HP:0004808)2.80776413
21Nephroblastoma (Wilms tumor) (HP:0002667)2.79154720
22Dysmetric saccades (HP:0000641)2.77928253
23Volvulus (HP:0002580)2.72204698
24Embryonal renal neoplasm (HP:0011794)2.69936985
25Agnosia (HP:0010524)2.69584774
26Deep philtrum (HP:0002002)2.67518904
27Basal cell carcinoma (HP:0002671)2.65586867
28Patellar aplasia (HP:0006443)2.65388448
29Neoplasm of the oral cavity (HP:0100649)2.63182886
30Degeneration of anterior horn cells (HP:0002398)2.62928879
31Abnormality of the anterior horn cell (HP:0006802)2.62928879
32Abnormal number of incisors (HP:0011064)2.61265199
33Missing ribs (HP:0000921)2.59714662
34Glioma (HP:0009733)2.59666531
35Absent radius (HP:0003974)2.57701689
36Biliary tract neoplasm (HP:0100574)2.50696760
37Aplasia/Hypoplasia of the patella (HP:0006498)2.47489963
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47310846
39Short 4th metacarpal (HP:0010044)2.47310846
40Increased nuchal translucency (HP:0010880)2.46456021
41Abnormality of DNA repair (HP:0003254)2.44347871
4211 pairs of ribs (HP:0000878)2.43647174
43Clubbing of toes (HP:0100760)2.42507498
44Meckel diverticulum (HP:0002245)2.42321233
45Neoplasm of striated muscle (HP:0009728)2.41973809
46IgA deficiency (HP:0002720)2.41825936
47Low anterior hairline (HP:0000294)2.41515994
48Aplasia/hypoplasia of the humerus (HP:0006507)2.40054103
49Aplasia involving forearm bones (HP:0009822)2.39197527
50Absent forearm bone (HP:0003953)2.39197527
51Abnormality of chromosome segregation (HP:0002916)2.37965453
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.37720195
53Fair hair (HP:0002286)2.36692431
54Neoplasm of the pancreas (HP:0002894)2.31644254
55Supernumerary spleens (HP:0009799)2.31631653
56Abnormality of the ileum (HP:0001549)2.31587753
57Atresia of the external auditory canal (HP:0000413)2.30925959
58Aplasia/Hypoplasia of the uvula (HP:0010293)2.29981917
59Protruding tongue (HP:0010808)2.26955468
60Abnormality of the pons (HP:0007361)2.25123564
61Short humerus (HP:0005792)2.23474559
62Amaurosis fugax (HP:0100576)2.21456075
63Facial hemangioma (HP:0000329)2.20737422
64Ectopic kidney (HP:0000086)2.19220350
65Abnormality of the preputium (HP:0100587)2.18957274
66Cortical dysplasia (HP:0002539)2.18549947
67Cutaneous melanoma (HP:0012056)2.18262097
68Prominent nose (HP:0000448)2.16946341
69Absent thumb (HP:0009777)2.14831117
70Rib fusion (HP:0000902)2.14744008
71Small intestinal stenosis (HP:0012848)2.13605888
72Duodenal stenosis (HP:0100867)2.13605888
73Myelodysplasia (HP:0002863)2.12294507
74Entropion (HP:0000621)2.10124440
75Hypoplasia of the pons (HP:0012110)2.09451420
76Oral leukoplakia (HP:0002745)2.09381949
77Carpal bone hypoplasia (HP:0001498)2.06750717
78Abdominal situs inversus (HP:0003363)2.05703929
79Abnormality of abdominal situs (HP:0011620)2.05703929
80Sparse lateral eyebrow (HP:0005338)2.05666207
81Abnormality of the calcaneus (HP:0008364)2.03767017
82Cafe-au-lait spot (HP:0000957)2.03702955
83Thyroid carcinoma (HP:0002890)2.02705118
84High pitched voice (HP:0001620)1.99680978
85Sloping forehead (HP:0000340)1.98706520
86Duplicated collecting system (HP:0000081)1.98367656
87Submucous cleft hard palate (HP:0000176)1.97545553
88Microvesicular hepatic steatosis (HP:0001414)1.97405245
89Curly hair (HP:0002212)1.97033687
90Progressive external ophthalmoplegia (HP:0000590)1.96607034
91Squamous cell carcinoma (HP:0002860)1.95826194
92Central scotoma (HP:0000603)1.94808576
93Glossoptosis (HP:0000162)1.94508070
94Septate vagina (HP:0001153)1.93971134
95Gastrointestinal carcinoma (HP:0002672)1.93701969
96Malignant gastrointestinal tract tumors (HP:0006749)1.93701969
97Pelvic girdle muscle weakness (HP:0003749)1.93511620
98Acute lymphatic leukemia (HP:0006721)1.93199127
99Progressive inability to walk (HP:0002505)1.92225810
100Abnormality of cells of the erythroid lineage (HP:0012130)1.91798437
101Rough bone trabeculation (HP:0100670)1.91295301
102Cystic hygroma (HP:0000476)1.90954775
103Aplasia cutis congenita (HP:0001057)1.90203099
104Neoplasm of the adrenal cortex (HP:0100641)1.89332479
105Arteriovenous malformation (HP:0100026)1.89293471
106Long eyelashes (HP:0000527)1.86677047
107Large earlobe (HP:0009748)1.86379187
108Ovarian neoplasm (HP:0100615)1.85127968
109Trismus (HP:0000211)1.84443539
110Neoplasm of the colon (HP:0100273)1.84094117
111Genetic anticipation (HP:0003743)1.83496644
112Cubitus valgus (HP:0002967)1.82840387
113Transitional cell carcinoma of the bladder (HP:0006740)1.81937335
114Abnormality of the duodenum (HP:0002246)1.81159989
115Adenoma sebaceum (HP:0009720)1.79790584
116Angiofibromas (HP:0010615)1.79790584
117Neoplasm of the small intestine (HP:0100833)1.78644938
118Short thumb (HP:0009778)1.78329348
119Abnormality of the renal collecting system (HP:0004742)1.77457522
120Truncal obesity (HP:0001956)1.77093323
121Abnormal lung lobation (HP:0002101)1.75948083
122Bladder carcinoma (HP:0002862)1.75021268
123Bladder neoplasm (HP:0009725)1.75021268
124Short chin (HP:0000331)1.74447992
125Hypoplastic labia majora (HP:0000059)1.73965337
126Sandal gap (HP:0001852)1.73907411
127Abnormality of the intrinsic pathway (HP:0010989)1.72915613
128Capillary hemangiomas (HP:0005306)1.72701658
129Ankle contracture (HP:0006466)1.72459236
130Premature graying of hair (HP:0002216)1.71709462
131Overlapping toe (HP:0001845)1.71350955
132Abnormal auditory evoked potentials (HP:0006958)1.71201323
133Uterine leiomyosarcoma (HP:0002891)1.69755959
134Leiomyosarcoma (HP:0100243)1.69755959
135Broad thumb (HP:0011304)1.69678182
136Horseshoe kidney (HP:0000085)1.69156362
137Freckling (HP:0001480)1.68453554
138Abnormality of the labia majora (HP:0012881)1.68125522
139Neoplasm of the rectum (HP:0100743)1.68058201
140Short palpebral fissure (HP:0012745)1.67916029
141Abnormality of the carotid arteries (HP:0005344)1.67793240
142Slender long bone (HP:0003100)1.67692312
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.66907876
144IgM deficiency (HP:0002850)1.66898441
145Long clavicles (HP:0000890)1.66791735
146Skull defect (HP:0001362)1.66489044
147Tracheoesophageal fistula (HP:0002575)1.66468060
148Abnormality of the 4th metacarpal (HP:0010012)1.66455537
149Shoulder girdle muscle weakness (HP:0003547)1.66367645
150Skin tags (HP:0010609)1.66031252
151Supernumerary ribs (HP:0005815)1.65301425
152Supernumerary bones of the axial skeleton (HP:0009144)1.65226792
153Facial cleft (HP:0002006)1.64363454
154Chronic hepatic failure (HP:0100626)1.64355302
155Renal cortical cysts (HP:0000803)1.62383026
156High anterior hairline (HP:0009890)1.62310656
157Heterotopia (HP:0002282)1.62163777
158Progressive muscle weakness (HP:0003323)1.61687407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.44961981
2WEE14.03365122
3CDK123.33259302
4BUB13.22329335
5FRK2.99146026
6NEK22.87274954
7SRPK12.76958671
8EIF2AK12.48471121
9TTK2.41988748
10ACVR1B2.28638358
11TSSK62.22590479
12NEK12.12049854
13EEF2K2.06802114
14BRSK21.92832275
15PKN21.91174284
16EPHA21.89345789
17RPS6KB21.85415230
18MKNK11.84414577
19PLK11.81762123
20ATR1.76440925
21CDK71.72869647
22BMPR1B1.72134998
23PASK1.69292930
24TLK11.64394608
25AURKB1.62487894
26PLK31.62029220
27STK101.59340849
28ERBB31.58577256
29MAP3K81.53617931
30MAP3K101.53349560
31CHEK11.53126145
32CHEK21.52860869
33AKT31.52256504
34RPS6KA41.52132626
35CDK41.51629562
36MKNK21.51547110
37MAP3K141.48876528
38PLK41.48540987
39BCR1.48426884
40DYRK31.47978567
41SCYL21.44152577
42BRD41.44078667
43PBK1.43832750
44NEK91.32420643
45ALK1.28888274
46VRK11.23045138
47TESK21.22301998
48FLT31.21544211
49EIF2AK31.21403072
50TGFBR11.21282558
51ATM1.16547678
52CCNB11.14196694
53STK31.13299259
54LATS11.06342654
55ZAK1.04530208
56AURKA1.03966190
57CDK21.03888841
58MELK1.03871876
59PNCK1.03660562
60BRSK11.00365110
61STK40.99774420
62PAK40.99132668
63CDK60.97744751
64MAP3K40.97293276
65CAMK1G0.96733590
66NME20.95556345
67CAMK1D0.94676482
68MTOR0.94645257
69TRIM280.91920623
70LATS20.88417345
71PIM10.86978315
72MST40.84403388
73TEC0.81546032
74STK240.80861564
75LRRK20.80053007
76CDK10.78254301
77PAK20.75873999
78TAF10.75761409
79NLK0.75086137
80CAMKK20.74067887
81CDK30.73410828
82FGFR10.70697582
83CSNK2A20.69934304
84TTN0.69920290
85SIK30.68445818
86TESK10.67916529
87CSNK1A1L0.67706845
88NUAK10.66469460
89STK390.64460358
90PDK40.63815154
91PDK30.63815154
92PDGFRA0.62632200
93TRPM70.62301663
94MAPKAPK50.60004042
95PAK10.58432710
96CSNK1E0.58325086
97ERBB40.58126692
98ICK0.56698471
99MET0.55348565
100CSNK1D0.53940244
101AKT20.53900210
102OXSR10.53776094
103TRIB30.53666739
104PRKDC0.53044564
105CDK80.51951304
106CSNK2A10.47837389
107CLK10.47228910
108RAF10.45530406
109RPS6KA50.45006777
110KSR10.44704736
111CDK90.41951101
112MAPK140.38884102
113STK38L0.38452029
114MST1R0.37989723
115TNIK0.37530757
116BLK0.37518304
117CSNK1G10.36665203
118MAPK110.35043063
119MAP2K30.34185821
120PRKCI0.33729524
121MAP3K50.33689793
122MAP4K20.33429768
123BRAF0.33084040
124WNK10.31892732
125PDGFRB0.30993911
126AKT10.29707793
127MAPK10.29483636
128DDR20.29161292
129GSK3B0.28633390
130PTK60.25504120
131RPS6KB10.24993570
132BMX0.23982926
133TYRO30.23972386
134MARK30.23529462
135ILK0.21201483
136MAPK100.20824004
137EIF2AK20.20060203
138MAP3K30.19844304
139RPS6KA10.19444420
140PDK20.18142674
141MAPK90.16477001

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51866791
2Mismatch repair_Homo sapiens_hsa034304.02086005
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99430900
4RNA transport_Homo sapiens_hsa030133.56936498
5Spliceosome_Homo sapiens_hsa030403.40951756
6One carbon pool by folate_Homo sapiens_hsa006703.22798900
7Cell cycle_Homo sapiens_hsa041103.02888500
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81589032
9Nucleotide excision repair_Homo sapiens_hsa034202.69069881
10Homologous recombination_Homo sapiens_hsa034402.68915401
11RNA polymerase_Homo sapiens_hsa030202.60588525
12Base excision repair_Homo sapiens_hsa034102.59642628
13Ribosome_Homo sapiens_hsa030102.39829119
14mRNA surveillance pathway_Homo sapiens_hsa030152.26757955
15Fanconi anemia pathway_Homo sapiens_hsa034602.21250640
16Non-homologous end-joining_Homo sapiens_hsa034502.06827125
17Pyrimidine metabolism_Homo sapiens_hsa002401.93168775
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91971098
19Systemic lupus erythematosus_Homo sapiens_hsa053221.87261907
20* RNA degradation_Homo sapiens_hsa030181.82203240
21Basal transcription factors_Homo sapiens_hsa030221.79572888
22Proteasome_Homo sapiens_hsa030501.79418880
23p53 signaling pathway_Homo sapiens_hsa041151.73632993
24Viral carcinogenesis_Homo sapiens_hsa052031.40505741
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38925691
26MicroRNAs in cancer_Homo sapiens_hsa052061.19090967
27Epstein-Barr virus infection_Homo sapiens_hsa051691.18862860
28Oocyte meiosis_Homo sapiens_hsa041141.16227336
29Selenocompound metabolism_Homo sapiens_hsa004501.04132749
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03379657
31Antigen processing and presentation_Homo sapiens_hsa046121.02484804
32HTLV-I infection_Homo sapiens_hsa051661.02111072
33Biosynthesis of amino acids_Homo sapiens_hsa012300.97186795
34Small cell lung cancer_Homo sapiens_hsa052220.96298163
35Herpes simplex infection_Homo sapiens_hsa051680.96099529
36Purine metabolism_Homo sapiens_hsa002300.95771724
37Protein export_Homo sapiens_hsa030600.94202430
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93046090
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.92735232
40Circadian rhythm_Homo sapiens_hsa047100.91669730
41TGF-beta signaling pathway_Homo sapiens_hsa043500.90389471
42Basal cell carcinoma_Homo sapiens_hsa052170.87222105
43Hippo signaling pathway_Homo sapiens_hsa043900.86114456
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84767586
45Propanoate metabolism_Homo sapiens_hsa006400.82337467
46Thyroid cancer_Homo sapiens_hsa052160.80163070
47Alcoholism_Homo sapiens_hsa050340.80134132
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.79424823
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71938172
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71661102
51Adherens junction_Homo sapiens_hsa045200.71207777
52Pentose phosphate pathway_Homo sapiens_hsa000300.70721317
53Colorectal cancer_Homo sapiens_hsa052100.69562298
54Fatty acid biosynthesis_Homo sapiens_hsa000610.69508422
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.69018903
56Notch signaling pathway_Homo sapiens_hsa043300.67414623
57B cell receptor signaling pathway_Homo sapiens_hsa046620.66416957
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66015042
59Chronic myeloid leukemia_Homo sapiens_hsa052200.65692334
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64251857
61Lysine degradation_Homo sapiens_hsa003100.62281374
62Bladder cancer_Homo sapiens_hsa052190.59688996
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57671371
64mTOR signaling pathway_Homo sapiens_hsa041500.55811084
65Hedgehog signaling pathway_Homo sapiens_hsa043400.53729095
66Proteoglycans in cancer_Homo sapiens_hsa052050.50532469
67Apoptosis_Homo sapiens_hsa042100.49177796
68Sulfur relay system_Homo sapiens_hsa041220.48952122
69Hepatitis B_Homo sapiens_hsa051610.48064220
70Legionellosis_Homo sapiens_hsa051340.47274381
71Vitamin B6 metabolism_Homo sapiens_hsa007500.47204160
72Inositol phosphate metabolism_Homo sapiens_hsa005620.46331117
73Pathways in cancer_Homo sapiens_hsa052000.45244585
74Regulation of autophagy_Homo sapiens_hsa041400.45010717
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44819828
76Pyruvate metabolism_Homo sapiens_hsa006200.44612502
77Prostate cancer_Homo sapiens_hsa052150.44518330
78Primary immunodeficiency_Homo sapiens_hsa053400.44151418
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43215495
80Viral myocarditis_Homo sapiens_hsa054160.42840689
81HIF-1 signaling pathway_Homo sapiens_hsa040660.42769294
82Carbon metabolism_Homo sapiens_hsa012000.42145157
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.41788812
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41784995
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41193357
86Wnt signaling pathway_Homo sapiens_hsa043100.41011810
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40076715
88Sphingolipid metabolism_Homo sapiens_hsa006000.39629665
89Steroid biosynthesis_Homo sapiens_hsa001000.38786045
90Tight junction_Homo sapiens_hsa045300.37179623
91Dorso-ventral axis formation_Homo sapiens_hsa043200.34917861
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33506264
93Glioma_Homo sapiens_hsa052140.33466582
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33399356
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32937935
96ErbB signaling pathway_Homo sapiens_hsa040120.32075076
97Folate biosynthesis_Homo sapiens_hsa007900.31416420
98Non-small cell lung cancer_Homo sapiens_hsa052230.30610218
99Shigellosis_Homo sapiens_hsa051310.29905819
100Hepatitis C_Homo sapiens_hsa051600.29891265
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29382121
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29220575
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28811600
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.28012094
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.27260394
106Acute myeloid leukemia_Homo sapiens_hsa052210.27153348
107T cell receptor signaling pathway_Homo sapiens_hsa046600.26492627
108Pancreatic cancer_Homo sapiens_hsa052120.24916727
109Renin-angiotensin system_Homo sapiens_hsa046140.24267644
110Melanoma_Homo sapiens_hsa052180.23953731
111Measles_Homo sapiens_hsa051620.23731712
112Prolactin signaling pathway_Homo sapiens_hsa049170.23034535
113Butanoate metabolism_Homo sapiens_hsa006500.22956153
114Endometrial cancer_Homo sapiens_hsa052130.22283288
115Focal adhesion_Homo sapiens_hsa045100.22212091
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22166758
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21142616
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20463746
119ECM-receptor interaction_Homo sapiens_hsa045120.20373710
120N-Glycan biosynthesis_Homo sapiens_hsa005100.19762073
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.19197439
122FoxO signaling pathway_Homo sapiens_hsa040680.18394910
123Long-term depression_Homo sapiens_hsa047300.18081547
124Influenza A_Homo sapiens_hsa051640.17808338
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15806344
126AMPK signaling pathway_Homo sapiens_hsa041520.15084498
127Glutathione metabolism_Homo sapiens_hsa004800.14778476
128Renal cell carcinoma_Homo sapiens_hsa052110.14492295
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.13858964
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13700268

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