DIMT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of calcium ion-dependent exocytosis (GO:0045955)8.25230978
2negative regulation of neurotransmitter secretion (GO:0046929)6.92099017
3nerve growth factor signaling pathway (GO:0038180)6.56803715
4negative regulation of neurotransmitter transport (GO:0051589)5.94865298
5protein neddylation (GO:0045116)5.91681794
6positive regulation of vasculogenesis (GO:2001214)5.75902579
7Rap protein signal transduction (GO:0032486)5.08961630
8purine nucleobase biosynthetic process (GO:0009113)4.73153899
9maturation of SSU-rRNA (GO:0030490)4.65195162
10nucleobase biosynthetic process (GO:0046112)4.53864745
11proteasome assembly (GO:0043248)4.39170588
12negative regulation of norepinephrine secretion (GO:0010700)4.38827356
13regulation of establishment of cell polarity (GO:2000114)4.27929647
14ribosomal small subunit assembly (GO:0000028)4.26431337
15DNA replication checkpoint (GO:0000076)4.19458834
16DNA replication initiation (GO:0006270)4.16711125
17DNA deamination (GO:0045006)4.13191539
18termination of RNA polymerase III transcription (GO:0006386)4.12365126
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.12365126
20ribosome biogenesis (GO:0042254)4.10900686
21DNA strand elongation involved in DNA replication (GO:0006271)4.09021748
22formation of translation preinitiation complex (GO:0001731)4.06209964
23response to pheromone (GO:0019236)4.03723397
247-methylguanosine mRNA capping (GO:0006370)4.03434386
25telomere maintenance via semi-conservative replication (GO:0032201)4.03151841
26ribonucleoprotein complex biogenesis (GO:0022613)4.02176013
27RNA capping (GO:0036260)3.99776514
287-methylguanosine RNA capping (GO:0009452)3.99776514
29mitotic metaphase plate congression (GO:0007080)3.98435346
30ribosomal large subunit biogenesis (GO:0042273)3.96968487
31CENP-A containing nucleosome assembly (GO:0034080)3.95470505
32positive regulation of granulocyte differentiation (GO:0030854)3.95249297
33ribosomal small subunit biogenesis (GO:0042274)3.93862109
34DNA strand elongation (GO:0022616)3.89829139
35regulation of vasculogenesis (GO:2001212)3.86409989
36cellular response to nerve growth factor stimulus (GO:1990090)3.83926185
37response to nerve growth factor (GO:1990089)3.83926185
38spliceosomal snRNP assembly (GO:0000387)3.82216759
39chromatin remodeling at centromere (GO:0031055)3.81644343
40* rRNA modification (GO:0000154)3.80414499
41pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.76016747
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74702590
43* rRNA processing (GO:0006364)3.74192986
44thrombin receptor signaling pathway (GO:0070493)3.74091317
45viral mRNA export from host cell nucleus (GO:0046784)3.73120167
46translational termination (GO:0006415)3.64542286
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64350134
48termination of RNA polymerase I transcription (GO:0006363)3.62891167
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62868414
50telomere maintenance via recombination (GO:0000722)3.62643169
51transcription-coupled nucleotide-excision repair (GO:0006283)3.62469949
52cullin deneddylation (GO:0010388)3.61102992
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60977327
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.60668850
55viral transcription (GO:0019083)3.60589707
56* rRNA metabolic process (GO:0016072)3.60537650
57transcription elongation from RNA polymerase I promoter (GO:0006362)3.59788828
58establishment of integrated proviral latency (GO:0075713)3.57806002
59ribosome assembly (GO:0042255)3.51234727
60cellular component biogenesis (GO:0044085)3.50075848
61protein deneddylation (GO:0000338)3.47631548
62pseudouridine synthesis (GO:0001522)3.46034826
63DNA replication-independent nucleosome assembly (GO:0006336)3.45268811
64DNA replication-independent nucleosome organization (GO:0034724)3.45268811
65metaphase plate congression (GO:0051310)3.44099351
66negative regulation of ligase activity (GO:0051352)3.43892256
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43892256
68transcription from RNA polymerase I promoter (GO:0006360)3.41778256
69spliceosomal complex assembly (GO:0000245)3.39952239
70mitotic recombination (GO:0006312)3.39545582
71maturation of 5.8S rRNA (GO:0000460)3.38548859
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38218320
73kinetochore organization (GO:0051383)3.38040330
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37053118
75translational initiation (GO:0006413)3.36584829
76replication fork processing (GO:0031297)3.34832438
77regulation of penile erection (GO:0060405)3.33447860
78telomere maintenance via telomere lengthening (GO:0010833)3.31513760
79kinetochore assembly (GO:0051382)3.31146949
80IMP biosynthetic process (GO:0006188)3.31130075
81definitive hemopoiesis (GO:0060216)3.30457729
82chaperone-mediated protein transport (GO:0072321)3.29392062
83regulation of mitochondrial translation (GO:0070129)3.27312348
84protein localization to kinetochore (GO:0034501)3.25844543
85relaxation of smooth muscle (GO:0044557)3.24514666
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23260723
87G1/S transition of mitotic cell cycle (GO:0000082)3.22969154
88cell cycle G1/S phase transition (GO:0044843)3.22969154
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22676091
90regulation of establishment or maintenance of cell polarity (GO:0032878)3.22017953
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.21079912
92translation (GO:0006412)3.20719970
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20397905
94histone exchange (GO:0043486)3.20331877
95translational elongation (GO:0006414)3.20048852
96DNA catabolic process, exonucleolytic (GO:0000738)3.18813947
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18713496
98cotranslational protein targeting to membrane (GO:0006613)3.18111660
99positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16610846
100negative regulation of heart rate (GO:0010459)3.13267529
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.13112732
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12663865
103protein targeting to ER (GO:0045047)3.11964175
104transcription initiation from RNA polymerase I promoter (GO:0006361)3.11950568
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.11441900
106attachment of spindle microtubules to kinetochore (GO:0008608)3.10860288
107DNA double-strand break processing (GO:0000729)3.10299831
108positive regulation of Rap GTPase activity (GO:0032854)3.10175763
109mitotic G2/M transition checkpoint (GO:0044818)3.07369539
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.07132452
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.07132452
112folic acid-containing compound biosynthetic process (GO:0009396)3.06840313
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06797446
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06797446
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06797446
116regulation of cellular amino acid metabolic process (GO:0006521)3.06498678
117transcription elongation from RNA polymerase II promoter (GO:0006368)3.05846448
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05727925
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05727925
120IMP metabolic process (GO:0046040)3.05555924
121* rRNA methylation (GO:0031167)3.05427807
122mitotic nuclear envelope disassembly (GO:0007077)3.05036562
123DNA-templated transcription, termination (GO:0006353)3.04524123
124purine nucleotide salvage (GO:0032261)3.04140261
125positive regulation of ligase activity (GO:0051351)3.03836859
126DNA-templated transcription, elongation (GO:0006354)3.03477534
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02451488
128peptidyl-histidine modification (GO:0018202)3.02349468
129cellular protein complex disassembly (GO:0043624)3.01566722
130DNA topological change (GO:0006265)3.01154670
131guanosine-containing compound biosynthetic process (GO:1901070)3.00915153
132regulation of platelet aggregation (GO:0090330)2.97072258
133pyrimidine nucleotide catabolic process (GO:0006244)2.96619481
134deoxyribose phosphate biosynthetic process (GO:0046385)2.93342632
1352-deoxyribonucleotide biosynthetic process (GO:0009265)2.93342632
136granulocyte differentiation (GO:0030851)2.92448454
137negative regulation of catecholamine secretion (GO:0033604)2.89610116
138regulation of inositol phosphate biosynthetic process (GO:0010919)2.86473203
139mitotic G2 DNA damage checkpoint (GO:0007095)2.81803220
140histone mRNA metabolic process (GO:0008334)2.80305677
141negative regulation of exocytosis (GO:0045920)2.79337491
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.78255244
143somatic diversification of immune receptors via somatic mutation (GO:0002566)2.75523497
144somatic hypermutation of immunoglobulin genes (GO:0016446)2.75523497
145regulation of Rap GTPase activity (GO:0032317)2.75168066
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74718385
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.74718385
148negative regulation of sister chromatid segregation (GO:0033046)2.74718385
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74718385
150negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74718385
151regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72641904
152regulation of mitotic spindle checkpoint (GO:1903504)2.72641904
153DNA unwinding involved in DNA replication (GO:0006268)2.70827657
154GMP metabolic process (GO:0046037)2.70444998
155regulation of centriole replication (GO:0046599)2.69291570
156negative regulation of chromosome segregation (GO:0051985)2.66825142
157spindle checkpoint (GO:0031577)2.66103827
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65011614
159purine-containing compound salvage (GO:0043101)2.64864897
160positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.64055238
161respiratory chain complex IV assembly (GO:0008535)2.63411793
162establishment of endothelial barrier (GO:0061028)2.62257848
163regulation of Golgi to plasma membrane protein transport (GO:0042996)2.62185759
164mitotic spindle checkpoint (GO:0071174)2.62027070
165mitochondrial RNA metabolic process (GO:0000959)2.61428094
166mitotic spindle assembly checkpoint (GO:0007094)2.61157965
167negative regulation of response to food (GO:0032096)2.60764391
168negative regulation of appetite (GO:0032099)2.60764391
169spindle assembly checkpoint (GO:0071173)2.59256102
170ether lipid metabolic process (GO:0046485)2.57696454
171deoxyribonucleotide biosynthetic process (GO:0009263)2.57542129
172DNA ligation (GO:0006266)2.56615811
173somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55308674
174somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55308674
175isotype switching (GO:0045190)2.55308674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70318886
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.56318033
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52725244
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.93084149
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.84635947
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73169716
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.51470325
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41060069
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40850293
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24515238
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19641847
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.13022441
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10625341
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.09778888
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06859786
16MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04191910
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82930655
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74354327
19VDR_23849224_ChIP-Seq_CD4+_Human2.69652892
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64003810
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54189961
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.45358886
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43163213
24XRN2_22483619_ChIP-Seq_HELA_Human2.37634906
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36394351
26FOXP3_21729870_ChIP-Seq_TREG_Human2.25857484
27DCP1A_22483619_ChIP-Seq_HELA_Human2.25110607
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24987480
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24783337
30SCL_19346495_ChIP-Seq_HPC-7_Human2.23366035
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21278293
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19027694
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16233895
34ELK1_19687146_ChIP-ChIP_HELA_Human2.15245286
35GABP_19822575_ChIP-Seq_HepG2_Human2.09555246
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06511564
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00419079
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.98546870
39TTF2_22483619_ChIP-Seq_HELA_Human1.97800547
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95249856
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.94761727
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94725278
43VDR_22108803_ChIP-Seq_LS180_Human1.93822999
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92241101
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90394572
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87363528
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74031848
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73457486
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72191360
50AR_21909140_ChIP-Seq_LNCAP_Human1.68572119
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.67775600
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65135943
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.63272313
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63253393
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62493600
56IGF1R_20145208_ChIP-Seq_DFB_Human1.60863528
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.57086278
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.55640839
59TAF15_26573619_Chip-Seq_HEK293_Human1.55405785
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54006746
61GATA1_22025678_ChIP-Seq_K562_Human1.53842702
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48999011
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47643016
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45171420
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45107479
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42061835
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39460597
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34054071
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31605513
70CIITA_25753668_ChIP-Seq_RAJI_Human1.30793972
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.29048677
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27746088
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.23820314
74MYC_18940864_ChIP-ChIP_HL60_Human1.23351976
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23302566
76KDM5A_27292631_Chip-Seq_BREAST_Human1.21194685
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20888700
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20336483
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17780713
80GBX2_23144817_ChIP-Seq_PC3_Human1.16003836
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09621895
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09432205
83P300_19829295_ChIP-Seq_ESCs_Human1.06651416
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06640389
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05621185
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05185676
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.04660288
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02571594
89ER_23166858_ChIP-Seq_MCF-7_Human1.01334135
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00074926
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00069299
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97354961
93ZNF274_21170338_ChIP-Seq_K562_Hela0.93938973
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92420829
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91075754
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91057565
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90532685
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90355466
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.90042988
100* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89229960
101IRF1_19129219_ChIP-ChIP_H3396_Human0.88454162
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87306486
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87074264
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86428399
105SALL1_21062744_ChIP-ChIP_HESCs_Human0.86087391
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85114580
107TFEB_21752829_ChIP-Seq_HELA_Human0.84137373
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82206985
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82135841
110ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82038301
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81582399
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81557900
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80970287
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.80189386
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79414487
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79322780
117SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78963125
118CRX_20693478_ChIP-Seq_RETINA_Mouse0.78515715
119* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76280152
120NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.74610955
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74420111
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73954511
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73702435
124NANOG_16153702_ChIP-ChIP_HESCs_Human0.73334280
125FUS_26573619_Chip-Seq_HEK293_Human0.72805861
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72620823
127EWS_26573619_Chip-Seq_HEK293_Human0.71978546
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.71632469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.21602615
2MP0005464_abnormal_platelet_physiology4.82773637
3MP0008057_abnormal_DNA_replication4.40548744
4MP0010094_abnormal_chromosome_stability4.25002364
5MP0004957_abnormal_blastocyst_morpholog4.11051493
6MP0003111_abnormal_nucleus_morphology3.87091894
7MP0008058_abnormal_DNA_repair3.73407739
8MP0003077_abnormal_cell_cycle3.56934561
9MP0003123_paternal_imprinting3.46614807
10MP0008932_abnormal_embryonic_tissue2.90560473
11MP0008007_abnormal_cellular_replicative2.69667810
12MP0005084_abnormal_gallbladder_morpholo2.67618242
13MP0008877_abnormal_DNA_methylation2.50787299
14MP0006292_abnormal_olfactory_placode2.49157784
15MP0003786_premature_aging2.34945415
16MP0003718_maternal_effect2.23412384
17MP0001188_hyperpigmentation2.10748276
18MP0001529_abnormal_vocalization2.04819575
19MP0004084_abnormal_cardiac_muscle2.00410631
20MP0009379_abnormal_foot_pigmentation1.99190531
21MP0003763_abnormal_thymus_physiology1.98728650
22MP0001986_abnormal_taste_sensitivity1.87639601
23MP0002396_abnormal_hematopoietic_system1.86365314
24MP0003315_abnormal_perineum_morphology1.85827236
25MP0003121_genomic_imprinting1.85096077
26MP0001730_embryonic_growth_arrest1.79248413
27MP0000350_abnormal_cell_proliferation1.74657038
28MP0005646_abnormal_pituitary_gland1.67270354
29MP0002736_abnormal_nociception_after1.53448569
30MP0004147_increased_porphyrin_level1.48042011
31MP0002163_abnormal_gland_morphology1.40106717
32MP0002210_abnormal_sex_determination1.36627022
33MP0003136_yellow_coat_color1.35398652
34MP0002102_abnormal_ear_morphology1.30222482
35MP0001697_abnormal_embryo_size1.28174798
36MP0002132_abnormal_respiratory_system1.27909820
37MP0002160_abnormal_reproductive_system1.23185309
38MP0005174_abnormal_tail_pigmentation1.19758608
39MP0004215_abnormal_myocardial_fiber1.18603210
40MP0003941_abnormal_skin_development1.17623550
41MP0002080_prenatal_lethality1.15392529
42MP0002398_abnormal_bone_marrow1.15211954
43MP0000689_abnormal_spleen_morphology1.14019516
44MP0002938_white_spotting1.13405717
45MP0009384_cardiac_valve_regurgitation1.13267652
46MP0001905_abnormal_dopamine_level1.13245125
47MP0003880_abnormal_central_pattern1.12821113
48MP0005380_embryogenesis_phenotype1.12725163
49MP0001672_abnormal_embryogenesis/_devel1.12725163
50MP0001293_anophthalmia1.12478384
51MP0000313_abnormal_cell_death1.11721503
52MP0001145_abnormal_male_reproductive1.09420815
53MP0008872_abnormal_physiological_respon1.06656021
54MP0002085_abnormal_embryonic_tissue1.05639182
55MP0003567_abnormal_fetal_cardiomyocyte1.04287553
56MP0003890_abnormal_embryonic-extraembry1.03338928
57MP0003787_abnormal_imprinting1.02402781
58MP0002095_abnormal_skin_pigmentation1.02201281
59MP0006035_abnormal_mitochondrial_morpho1.00573161
60MP0001929_abnormal_gametogenesis1.00513679
61MP0000490_abnormal_crypts_of0.99823422
62MP0009333_abnormal_splenocyte_physiolog0.98627349
63MP0006036_abnormal_mitochondrial_physio0.98600038
64MP0000358_abnormal_cell_content/0.96360386
65MP0000653_abnormal_sex_gland0.96089396
66MP0003984_embryonic_growth_retardation0.93778091
67MP0002722_abnormal_immune_system0.93539504
68MP0001968_abnormal_touch/_nociception0.92846883
69MP0004134_abnormal_chest_morphology0.92783025
70MP0000465_gastrointestinal_hemorrhage0.92312139
71MP0002751_abnormal_autonomic_nervous0.91827544
72MP0008004_abnormal_stomach_pH0.91566336
73MP0001542_abnormal_bone_strength0.91559331
74MP0006072_abnormal_retinal_apoptosis0.90713119
75MP0008260_abnormal_autophagy0.90233848
76MP0002019_abnormal_tumor_incidence0.89386223
77MP0005409_darkened_coat_color0.89255416
78MP0002088_abnormal_embryonic_growth/wei0.88714661
79MP0008775_abnormal_heart_ventricle0.87939701
80MP0002638_abnormal_pupillary_reflex0.87617510
81MP0000015_abnormal_ear_pigmentation0.87253862
82MP0005389_reproductive_system_phenotype0.86577154
83MP0005379_endocrine/exocrine_gland_phen0.86124189
84MP0000372_irregular_coat_pigmentation0.84270826
85MP0004808_abnormal_hematopoietic_stem0.84104764
86MP0006054_spinal_hemorrhage0.82379908
87MP0002084_abnormal_developmental_patter0.82185484
88MP0000230_abnormal_systemic_arterial0.82011564
89MP0010307_abnormal_tumor_latency0.80179232
90MP0003950_abnormal_plasma_membrane0.79782506
91MP0004133_heterotaxia0.79649132
92MP0010030_abnormal_orbit_morphology0.78822864
93MP0004036_abnormal_muscle_relaxation0.78212662
94MP0000013_abnormal_adipose_tissue0.77834030
95MP0009697_abnormal_copulation0.77129931
96MP0001727_abnormal_embryo_implantation0.74987537
97MP0003656_abnormal_erythrocyte_physiolo0.74717961
98MP0004197_abnormal_fetal_growth/weight/0.74212355
99MP0002177_abnormal_outer_ear0.74057142
100MP0003938_abnormal_ear_development0.72215868
101MP0000566_synostosis0.71390470
102MP0008789_abnormal_olfactory_epithelium0.71278623
103MP0004142_abnormal_muscle_tone0.70168383
104MP0003122_maternal_imprinting0.70124119
105MP0005499_abnormal_olfactory_system0.70041375
106MP0005394_taste/olfaction_phenotype0.70041375
107MP0008770_decreased_survivor_rate0.69688544
108MP0002429_abnormal_blood_cell0.69330350
109MP0003806_abnormal_nucleotide_metabolis0.69189806
110MP0000049_abnormal_middle_ear0.69174549
111MP0005397_hematopoietic_system_phenotyp0.68269379
112MP0001545_abnormal_hematopoietic_system0.68269379
113MP0000703_abnormal_thymus_morphology0.66258781
114MP0005645_abnormal_hypothalamus_physiol0.65998481
115MP0003698_abnormal_male_reproductive0.65425496
116MP0006276_abnormal_autonomic_nervous0.65133403
117MP0002086_abnormal_extraembryonic_tissu0.64948511
118MP0001191_abnormal_skin_condition0.64260275
119MP0001984_abnormal_olfaction0.64061307
120MP0005266_abnormal_metabolism0.63785947
121MP0001485_abnormal_pinna_reflex0.63459374
122MP0001119_abnormal_female_reproductive0.63411773
123MP0001286_abnormal_eye_development0.63259813
124MP0003937_abnormal_limbs/digits/tail_de0.63216778
125MP0005075_abnormal_melanosome_morpholog0.62737024
126MP0002277_abnormal_respiratory_mucosa0.62188605
127MP0003221_abnormal_cardiomyocyte_apopto0.62072803
128MP0005384_cellular_phenotype0.61726777
129MP0001919_abnormal_reproductive_system0.60807058
130MP0002233_abnormal_nose_morphology0.60640202
131MP0003186_abnormal_redox_activity0.60614256
132MP0001661_extended_life_span0.59383847
133MP0001186_pigmentation_phenotype0.58055000

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.62925462
2Prolonged bleeding time (HP:0003010)4.66795778
3Breast hypoplasia (HP:0003187)4.42134823
4Abnormality of cells of the erythroid lineage (HP:0012130)4.08960408
5Abnormal number of erythroid precursors (HP:0012131)3.93824100
6Cerebral hypomyelination (HP:0006808)3.85930890
7Abnormal platelet function (HP:0011869)3.69244856
8Impaired platelet aggregation (HP:0003540)3.69244856
9Aplastic anemia (HP:0001915)3.66543200
10Reticulocytopenia (HP:0001896)3.60634709
11Carpal bone hypoplasia (HP:0001498)3.52156365
12Acanthocytosis (HP:0001927)3.44966287
13Increased mean platelet volume (HP:0011877)3.42283633
14Acute necrotizing encephalopathy (HP:0006965)3.22671754
15Petechiae (HP:0000967)3.08500038
16Abnormal platelet volume (HP:0011876)3.05021176
17Patellar aplasia (HP:0006443)2.98133551
18Mitochondrial inheritance (HP:0001427)2.95389127
19Abnormality of the labia minora (HP:0012880)2.94743471
20Type 2 muscle fiber atrophy (HP:0003554)2.94076234
213-Methylglutaconic aciduria (HP:0003535)2.89421698
22Abnormal mitochondria in muscle tissue (HP:0008316)2.88456305
23Macrocytic anemia (HP:0001972)2.84532530
24Aplasia/Hypoplasia of the patella (HP:0006498)2.82138022
25Oral leukoplakia (HP:0002745)2.80414402
26Volvulus (HP:0002580)2.78677647
27Increased CSF lactate (HP:0002490)2.76621412
28Rough bone trabeculation (HP:0100670)2.75897200
29Muscle fiber atrophy (HP:0100295)2.75633084
30Chromsome breakage (HP:0040012)2.75129537
31Irregular epiphyses (HP:0010582)2.67901986
32Hepatocellular necrosis (HP:0001404)2.67504305
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65811418
34Colon cancer (HP:0003003)2.65240657
35Dyschromatopsia (HP:0007641)2.64795395
36Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60851896
37Acute myeloid leukemia (HP:0004808)2.58594785
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58297020
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.57862795
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.57862795
41Abnormality of the preputium (HP:0100587)2.56992577
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.56435906
43Meckel diverticulum (HP:0002245)2.55495690
44Epistaxis (HP:0000421)2.55260754
45Pallor (HP:0000980)2.54642707
46Increased serum lactate (HP:0002151)2.54382760
47Poikilocytosis (HP:0004447)2.53790789
48Menorrhagia (HP:0000132)2.53288453
49Abnormality of methionine metabolism (HP:0010901)2.49421541
50Progressive macrocephaly (HP:0004481)2.46869981
51Premature graying of hair (HP:0002216)2.43063967
52B lymphocytopenia (HP:0010976)2.42848579
53Reduced antithrombin III activity (HP:0001976)2.42272329
54Abnormality of the ileum (HP:0001549)2.42229574
55Increased hepatocellular lipid droplets (HP:0006565)2.41516960
56Supernumerary spleens (HP:0009799)2.41076462
57Agnosia (HP:0010524)2.40766173
58CNS hypomyelination (HP:0003429)2.38637526
59Abnormality of the anterior horn cell (HP:0006802)2.36588815
60Degeneration of anterior horn cells (HP:0002398)2.36588815
61Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35896210
62Absent radius (HP:0003974)2.35730849
63Microretrognathia (HP:0000308)2.35293332
64Abnormality of B cell number (HP:0010975)2.35187698
65Renal cortical cysts (HP:0000803)2.34206721
66Increased serum pyruvate (HP:0003542)2.34012265
67Abnormality of glycolysis (HP:0004366)2.34012265
68Acute encephalopathy (HP:0006846)2.29092242
69Horseshoe kidney (HP:0000085)2.28615994
70Microvesicular hepatic steatosis (HP:0001414)2.26289748
71Adrenal hypoplasia (HP:0000835)2.25114906
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.24321201
73Acute lymphatic leukemia (HP:0006721)2.23780410
74Absent epiphyses (HP:0010577)2.22818194
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.22818194
76Abnormality of chromosome stability (HP:0003220)2.22685120
77Impulsivity (HP:0100710)2.22202832
78Absent forearm bone (HP:0003953)2.19048489
79Aplasia involving forearm bones (HP:0009822)2.19048489
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17582719
81Abnormality of serum amino acid levels (HP:0003112)2.17319859
82Abnormal lung lobation (HP:0002101)2.17091042
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16669714
84Type I transferrin isoform profile (HP:0003642)2.14611828
85Severe combined immunodeficiency (HP:0004430)2.13458271
86Decreased central vision (HP:0007663)2.12927187
87Myelodysplasia (HP:0002863)2.10376646
88Conjunctival telangiectasia (HP:0000524)2.10304954
89Panhypogammaglobulinemia (HP:0003139)2.09378156
90Exercise intolerance (HP:0003546)2.07576327
91Selective tooth agenesis (HP:0001592)2.07249601
92Absent thumb (HP:0009777)2.07047577
93Triphalangeal thumb (HP:0001199)2.06583060
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.06554381
95Postnatal microcephaly (HP:0005484)2.06422433
96Bone marrow hypocellularity (HP:0005528)2.06051386
97Pancreatic fibrosis (HP:0100732)2.02139876
98Methylmalonic acidemia (HP:0002912)1.98917784
99Secondary amenorrhea (HP:0000869)1.98695971
100Glossoptosis (HP:0000162)1.98523315
101Stenosis of the external auditory canal (HP:0000402)1.98448812
102Abnormal trabecular bone morphology (HP:0100671)1.98318284
103Cerebral edema (HP:0002181)1.97809882
104Cleft eyelid (HP:0000625)1.97758166
105Multiple enchondromatosis (HP:0005701)1.97656608
106Medulloblastoma (HP:0002885)1.96048490
107Duodenal stenosis (HP:0100867)1.94921260
108Small intestinal stenosis (HP:0012848)1.94921260
109Lipid accumulation in hepatocytes (HP:0006561)1.94831340
110Exertional dyspnea (HP:0002875)1.93301867
111Nephroblastoma (Wilms tumor) (HP:0002667)1.92539281
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92378955
113Renal Fanconi syndrome (HP:0001994)1.91462632
114Pancytopenia (HP:0001876)1.91299329
115Papillary thyroid carcinoma (HP:0002895)1.90914571
116Sloping forehead (HP:0000340)1.89942056
117Clubbing of toes (HP:0100760)1.88345624
118Hepatic necrosis (HP:0002605)1.87841156
119Neuroblastoma (HP:0003006)1.87267709
120Primitive neuroectodermal tumor (HP:0030065)1.87267709
121Neuroblastic tumors (HP:0004376)1.87267709
122Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87267709
123Abnormality of alanine metabolism (HP:0010916)1.87087043
124Hyperalaninemia (HP:0003348)1.87087043
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87087043
126Abnormal spermatogenesis (HP:0008669)1.85727289
127Embryonal renal neoplasm (HP:0011794)1.85471555
128Pancreatic cysts (HP:0001737)1.85471148
129Thyroid-stimulating hormone excess (HP:0002925)1.83157374
130Duplicated collecting system (HP:0000081)1.83014685
131Combined immunodeficiency (HP:0005387)1.82566596
132Medial flaring of the eyebrow (HP:0010747)1.81769650
133Lactic acidosis (HP:0003128)1.81506057
134Submucous cleft hard palate (HP:0000176)1.81103287
135Molar tooth sign on MRI (HP:0002419)1.80499059
136Abnormality of midbrain morphology (HP:0002418)1.80499059
137Ependymoma (HP:0002888)1.80453376
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80061702
139Abnormal protein N-linked glycosylation (HP:0012347)1.80061702
140Abnormal protein glycosylation (HP:0012346)1.80061702
141Abnormal glycosylation (HP:0012345)1.80061702
142Unsteady gait (HP:0002317)1.77655505
143Neoplasm of the pancreas (HP:0002894)1.76025973
144Rhabdomyosarcoma (HP:0002859)1.75532137
145Abnormal pupillary function (HP:0007686)1.75210328
146Cellular immunodeficiency (HP:0005374)1.75179119
147Abnormal number of incisors (HP:0011064)1.74780636
148Abnormality of lateral ventricle (HP:0030047)1.73234258
149Increased intramyocellular lipid droplets (HP:0012240)1.71161804
150Facial hemangioma (HP:0000329)1.69118204
151IgG deficiency (HP:0004315)1.68685667
152Aplasia/Hypoplasia of the thymus (HP:0010515)1.67431922
153Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67042889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.55057757
2WEE14.10134500
3NUAK13.32601721
4EIF2AK13.18775130
5STK163.18447373
6CDK193.13839210
7SRPK13.08861941
8CDC72.86738035
9TRIM282.81968798
10NME22.62102105
11TSSK62.60757567
12VRK12.57246636
13ACVR1B2.54205634
14MKNK22.51760061
15MKNK12.36726446
16PLK42.30286686
17EIF2AK32.17189651
18CCNB12.14089159
19BRSK22.09249204
20PLK31.89221776
21TLK11.86340258
22CASK1.84348882
23VRK21.77242804
24TAOK31.75602460
25NME11.70412020
26PLK11.68796353
27TAF11.60403781
28STK31.56879681
29DYRK31.54829571
30STK391.49402297
31PNCK1.47021785
32NEK21.41887250
33NEK11.40931619
34TESK21.40897006
35TTK1.40216427
36BRD41.32142959
37CDK71.25873331
38ZAK1.20586836
39BRSK11.17550960
40CHEK21.17094814
41CDK61.15153899
42BMPR21.15034073
43AURKA1.13627139
44ATR1.13003246
45PBK1.12086508
46TNIK1.11448660
47AURKB1.10521467
48BMPR1B1.08297996
49DYRK21.03256519
50CDK81.03136678
51CSNK1G10.99801517
52PIM20.98291846
53BRAF0.97820675
54CSNK1G20.97214049
55AKT30.96667746
56TGFBR10.94394329
57MAP3K120.93391421
58PRKG20.93362606
59EIF2AK20.91650119
60BTK0.91220595
61RPS6KA40.88673488
62ERBB30.87656436
63WNK40.85380768
64PIK3CG0.84962785
65PASK0.77934521
66CHEK10.77751635
67MINK10.76427535
68PLK20.75818512
69WNK30.71606101
70BCKDK0.71477312
71MAP4K20.70939528
72NEK60.70561284
73MST40.69376179
74CSNK2A10.68395111
75CSNK2A20.66336941
76TAOK20.65785285
77BCR0.65178109
78ILK0.64971578
79PRKCI0.63509043
80RAF10.62668550
81RIPK40.60691457
82PRKCQ0.60445443
83RPS6KB20.56662682
84CDK30.56434816
85PRPF4B0.55866059
86YES10.55197290
87ATM0.53896775
88PINK10.52884638
89CDK20.52648184
90DAPK10.52495289
91LIMK10.50671043
92HIPK20.49778098
93RPS6KA50.49520402
94SYK0.48553285
95STK240.48184809
96CDK10.47471374
97BMX0.47264817
98ITK0.46851635
99MAP3K80.46281616
100ALK0.45757751
101CDK40.44691904
102PRKG10.44522319
103CDK11A0.44076896
104PAK10.44012132
105MYLK0.43248165
106DMPK0.42815491
107CSNK1G30.42693274
108MAP2K70.42315610
109CLK10.41384189
110CDK90.40833130
111ADRBK20.37636785
112MAP3K50.36807989
113GRK50.36428199
114CDK180.35290289
115STK40.34738023
116CDK140.33960117
117MAPK130.32196727
118CDK150.31272010
119MELK0.31099940
120ABL20.31006451
121GRK70.29961046
122TXK0.29338586
123ARAF0.27534839
124SCYL20.27509428
125PAK40.27326431
126MUSK0.27151846
127PIM10.25778828
128OXSR10.24876817
129EPHA20.24344353
130CSNK1E0.23691175
131TEC0.23244930
132RPS6KB10.22974879
133CAMKK20.21662248
134MAP3K40.21475519
135SIK30.19444786
136PRKCG0.18950772

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.37375727
2DNA replication_Homo sapiens_hsa030304.18777110
3Proteasome_Homo sapiens_hsa030504.06628757
4Ribosome_Homo sapiens_hsa030103.96402420
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92726369
6Mismatch repair_Homo sapiens_hsa034303.91932356
7Spliceosome_Homo sapiens_hsa030403.16363476
8RNA transport_Homo sapiens_hsa030132.93859245
9Homologous recombination_Homo sapiens_hsa034402.91065253
10Nucleotide excision repair_Homo sapiens_hsa034202.86028564
11Pyrimidine metabolism_Homo sapiens_hsa002402.78787160
12Base excision repair_Homo sapiens_hsa034102.62061679
13Basal transcription factors_Homo sapiens_hsa030222.31281996
14Platelet activation_Homo sapiens_hsa046112.28594226
15Cell cycle_Homo sapiens_hsa041102.28095670
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11835628
17Fanconi anemia pathway_Homo sapiens_hsa034602.06266028
18RNA degradation_Homo sapiens_hsa030181.97648320
19Non-homologous end-joining_Homo sapiens_hsa034501.86375609
20Oxidative phosphorylation_Homo sapiens_hsa001901.81549765
21Protein export_Homo sapiens_hsa030601.76704142
22Purine metabolism_Homo sapiens_hsa002301.76677445
23One carbon pool by folate_Homo sapiens_hsa006701.66630528
24Parkinsons disease_Homo sapiens_hsa050121.65610484
25Fatty acid elongation_Homo sapiens_hsa000621.61007184
26Huntingtons disease_Homo sapiens_hsa050161.51823086
27mRNA surveillance pathway_Homo sapiens_hsa030151.42963861
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31239602
29Vitamin B6 metabolism_Homo sapiens_hsa007501.30090534
30p53 signaling pathway_Homo sapiens_hsa041151.20578546
31Propanoate metabolism_Homo sapiens_hsa006401.16928074
32Epstein-Barr virus infection_Homo sapiens_hsa051691.14278140
33Sulfur metabolism_Homo sapiens_hsa009201.11274521
34Selenocompound metabolism_Homo sapiens_hsa004501.07160832
35Olfactory transduction_Homo sapiens_hsa047401.04824039
36Oocyte meiosis_Homo sapiens_hsa041141.02693759
37Phototransduction_Homo sapiens_hsa047441.00523894
38Long-term potentiation_Homo sapiens_hsa047200.96500863
39Alzheimers disease_Homo sapiens_hsa050100.96062562
40Long-term depression_Homo sapiens_hsa047300.91553098
41Folate biosynthesis_Homo sapiens_hsa007900.88089846
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84996390
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84898994
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83973953
45Steroid biosynthesis_Homo sapiens_hsa001000.83513231
46Systemic lupus erythematosus_Homo sapiens_hsa053220.80810177
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79614865
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76736417
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74338447
50Gap junction_Homo sapiens_hsa045400.73116626
51Sulfur relay system_Homo sapiens_hsa041220.71654991
52Pyruvate metabolism_Homo sapiens_hsa006200.71608619
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.70906747
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70841549
55Pancreatic secretion_Homo sapiens_hsa049720.66095008
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65442563
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59561176
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59066284
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57298132
60Regulation of autophagy_Homo sapiens_hsa041400.55789456
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53991677
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53155636
63Circadian entrainment_Homo sapiens_hsa047130.52067102
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51173890
65Alcoholism_Homo sapiens_hsa050340.47786201
66Pentose phosphate pathway_Homo sapiens_hsa000300.46169470
67Viral carcinogenesis_Homo sapiens_hsa052030.45833635
68Herpes simplex infection_Homo sapiens_hsa051680.45729647
69Nicotine addiction_Homo sapiens_hsa050330.45116072
70Antigen processing and presentation_Homo sapiens_hsa046120.42534901
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.42281051
72Biosynthesis of amino acids_Homo sapiens_hsa012300.41577009
73Collecting duct acid secretion_Homo sapiens_hsa049660.39857114
74Dopaminergic synapse_Homo sapiens_hsa047280.39426097
75Metabolic pathways_Homo sapiens_hsa011000.38922887
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38767281
77Renin secretion_Homo sapiens_hsa049240.37889058
78Glutathione metabolism_Homo sapiens_hsa004800.37095777
79Salivary secretion_Homo sapiens_hsa049700.36340109
80Peroxisome_Homo sapiens_hsa041460.36057110
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34329125
82Cardiac muscle contraction_Homo sapiens_hsa042600.33981209
83Vibrio cholerae infection_Homo sapiens_hsa051100.33359185
84Nitrogen metabolism_Homo sapiens_hsa009100.33037912
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.31098964
86Arachidonic acid metabolism_Homo sapiens_hsa005900.30567263
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28543875
88Autoimmune thyroid disease_Homo sapiens_hsa053200.27352660
89HTLV-I infection_Homo sapiens_hsa051660.26277295
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25732316
91Hedgehog signaling pathway_Homo sapiens_hsa043400.24698779
92Morphine addiction_Homo sapiens_hsa050320.24475017
93Butanoate metabolism_Homo sapiens_hsa006500.23775189
94Thyroid cancer_Homo sapiens_hsa052160.23401840
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22983439
96Type I diabetes mellitus_Homo sapiens_hsa049400.22309711
97Allograft rejection_Homo sapiens_hsa053300.21867117
98GABAergic synapse_Homo sapiens_hsa047270.21213122
99Asthma_Homo sapiens_hsa053100.19797037
100Renin-angiotensin system_Homo sapiens_hsa046140.19233153
101N-Glycan biosynthesis_Homo sapiens_hsa005100.18587628
102Melanoma_Homo sapiens_hsa052180.18441452
103Ras signaling pathway_Homo sapiens_hsa040140.18184054
104TGF-beta signaling pathway_Homo sapiens_hsa043500.18006587
105Primary immunodeficiency_Homo sapiens_hsa053400.17459118
106Pancreatic cancer_Homo sapiens_hsa052120.17302757
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.16784817
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15523996
109Legionellosis_Homo sapiens_hsa051340.15226091
110Glycerolipid metabolism_Homo sapiens_hsa005610.14860227
111Shigellosis_Homo sapiens_hsa051310.14510171
112Hematopoietic cell lineage_Homo sapiens_hsa046400.14270278
113Rheumatoid arthritis_Homo sapiens_hsa053230.13176953
114Sphingolipid metabolism_Homo sapiens_hsa006000.12791668
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12650402
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12171064
117Fructose and mannose metabolism_Homo sapiens_hsa000510.08477348
118Ether lipid metabolism_Homo sapiens_hsa005650.06561531
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.06539690
120HIF-1 signaling pathway_Homo sapiens_hsa040660.06326486
121Amphetamine addiction_Homo sapiens_hsa050310.05668247
122Synaptic vesicle cycle_Homo sapiens_hsa047210.04972186
123Taste transduction_Homo sapiens_hsa047420.04801754
124Wnt signaling pathway_Homo sapiens_hsa043100.04337514
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.03924031
126Phagosome_Homo sapiens_hsa041450.03727710
127Linoleic acid metabolism_Homo sapiens_hsa005910.03686845
128Measles_Homo sapiens_hsa051620.03660341
129Serotonergic synapse_Homo sapiens_hsa047260.03349197
130Arginine and proline metabolism_Homo sapiens_hsa003300.01121659
131MicroRNAs in cancer_Homo sapiens_hsa052060.00900714
132Carbon metabolism_Homo sapiens_hsa012000.00829487
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00417008

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