DIABLO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.95270119
2fusion of sperm to egg plasma membrane (GO:0007342)4.67664689
3central nervous system myelination (GO:0022010)4.58264684
4axon ensheathment in central nervous system (GO:0032291)4.58264684
5male meiosis (GO:0007140)4.46592368
6protein neddylation (GO:0045116)4.45278385
7cilium or flagellum-dependent cell motility (GO:0001539)4.42239285
8DNA methylation involved in gamete generation (GO:0043046)4.39526265
9synaptonemal complex organization (GO:0070193)4.36194619
10L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.13027032
11synaptonemal complex assembly (GO:0007130)4.11009505
12fatty acid elongation (GO:0030497)4.03284420
13sperm-egg recognition (GO:0035036)3.91557947
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90676951
15proteasome assembly (GO:0043248)3.89976121
16binding of sperm to zona pellucida (GO:0007339)3.89702469
17DNA deamination (GO:0045006)3.89457522
18respiratory chain complex IV assembly (GO:0008535)3.87588776
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.85150506
20termination of RNA polymerase III transcription (GO:0006386)3.85150506
21male meiosis I (GO:0007141)3.80287205
22cullin deneddylation (GO:0010388)3.75851862
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.74350677
24negative regulation of ligase activity (GO:0051352)3.74350677
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72730482
26axonemal dynein complex assembly (GO:0070286)3.64344579
27regulation of mitochondrial translation (GO:0070129)3.63753387
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63409210
29DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63043958
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62201801
31sperm motility (GO:0030317)3.59772316
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58055530
33ATP synthesis coupled proton transport (GO:0015986)3.58055530
34signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57460088
35intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57460088
36organelle disassembly (GO:1903008)3.57233454
37GTP biosynthetic process (GO:0006183)3.56119492
38regulation of cellular amino acid metabolic process (GO:0006521)3.55910550
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54439890
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54439890
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54439890
42acrosome reaction (GO:0007340)3.51706015
43ribonucleoprotein complex disassembly (GO:0032988)3.50653482
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49269938
457-methylguanosine mRNA capping (GO:0006370)3.46401583
46meiosis I (GO:0007127)3.46185597
47protein deneddylation (GO:0000338)3.45715405
48protein-cofactor linkage (GO:0018065)3.45593349
49nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43496030
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.43425488
51NADH dehydrogenase complex assembly (GO:0010257)3.43425488
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43425488
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.42602531
54signal transduction involved in DNA integrity checkpoint (GO:0072401)3.42602531
55chaperone-mediated protein transport (GO:0072321)3.40834770
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40724922
577-methylguanosine RNA capping (GO:0009452)3.40251005
58RNA capping (GO:0036260)3.40251005
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.39642494
60DNA damage response, detection of DNA damage (GO:0042769)3.37220223
61cytochrome complex assembly (GO:0017004)3.36248123
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35643183
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35643183
64cell-cell recognition (GO:0009988)3.35634907
65pseudouridine synthesis (GO:0001522)3.35273527
66multicellular organism reproduction (GO:0032504)3.33706826
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33618753
68meiotic nuclear division (GO:0007126)3.33486331
69ribosomal small subunit biogenesis (GO:0042274)3.32505177
70spermatid development (GO:0007286)3.26125848
71chromosome organization involved in meiosis (GO:0070192)3.24737564
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22254112
73epithelial cilium movement (GO:0003351)3.21264084
74amino acid salvage (GO:0043102)3.19024645
75L-methionine salvage (GO:0071267)3.19024645
76L-methionine biosynthetic process (GO:0071265)3.19024645
77guanosine-containing compound biosynthetic process (GO:1901070)3.18360214
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17011913
79UTP biosynthetic process (GO:0006228)3.16975076
80behavioral response to nicotine (GO:0035095)3.15656055
81protein complex biogenesis (GO:0070271)3.14937296
82plasma membrane fusion (GO:0045026)3.13970265
83ribosomal small subunit assembly (GO:0000028)3.13910973
84positive regulation of mitochondrial fission (GO:0090141)3.13837440
85positive regulation of ligase activity (GO:0051351)3.13595594
86peptidyl-histidine modification (GO:0018202)3.08929864
87microtubule polymerization or depolymerization (GO:0031109)3.06094786
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.03407994
89regulation of cilium movement (GO:0003352)3.02231303
90histone exchange (GO:0043486)3.01801954
91base-excision repair, AP site formation (GO:0006285)3.01771975
92establishment of integrated proviral latency (GO:0075713)3.01578281
93regulation of ubiquitin-protein transferase activity (GO:0051438)2.99303758
94regulation of ligase activity (GO:0051340)2.97238400
95mitochondrial respiratory chain complex assembly (GO:0033108)2.95248059
96blastocyst development (GO:0001824)2.95182590
97protein K6-linked ubiquitination (GO:0085020)2.95175879
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95094424
99CENP-A containing nucleosome assembly (GO:0034080)2.94694021
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92987844
101protein targeting to mitochondrion (GO:0006626)2.91174029
102respiratory electron transport chain (GO:0022904)2.90328191
103electron transport chain (GO:0022900)2.89027072
104spliceosomal snRNP assembly (GO:0000387)2.88649843
105chromatin remodeling at centromere (GO:0031055)2.88551416
106maturation of SSU-rRNA (GO:0030490)2.88495716
107establishment of protein localization to mitochondrion (GO:0072655)2.87659529
108acrosome assembly (GO:0001675)2.87325305
109DNA strand elongation involved in DNA replication (GO:0006271)2.86982206
110protein localization to mitochondrion (GO:0070585)2.86818567
111GPI anchor biosynthetic process (GO:0006506)2.86712306
112cotranslational protein targeting to membrane (GO:0006613)2.86521525
113viral transcription (GO:0019083)2.85274971
114telomere maintenance via semi-conservative replication (GO:0032201)2.84671859
115tRNA processing (GO:0008033)2.84647306
116water-soluble vitamin biosynthetic process (GO:0042364)2.84351741
117DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.84165423
118negative regulation of transcription regulatory region DNA binding (GO:2000678)2.83372452
119regulation of sarcomere organization (GO:0060297)2.83313491
120transcription-coupled nucleotide-excision repair (GO:0006283)2.83186085
121CTP metabolic process (GO:0046036)2.82827498
122CTP biosynthetic process (GO:0006241)2.82827498
123mannosylation (GO:0097502)2.82604710
124rRNA modification (GO:0000154)2.82500433
125preassembly of GPI anchor in ER membrane (GO:0016254)2.78773732
126replication fork processing (GO:0031297)2.74712461
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73612236
128ubiquinone biosynthetic process (GO:0006744)2.65456352
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.63487018
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63487018
131tRNA metabolic process (GO:0006399)2.62721971
132ubiquinone metabolic process (GO:0006743)2.58956485
133iron-sulfur cluster assembly (GO:0016226)2.58686097
134metallo-sulfur cluster assembly (GO:0031163)2.58686097
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.58485589
136histone H2A acetylation (GO:0043968)2.58457548
137DNA double-strand break processing (GO:0000729)2.58423776
138postreplication repair (GO:0006301)2.57036469
139cornea development in camera-type eye (GO:0061303)2.57024510
140platelet dense granule organization (GO:0060155)2.56455554
141L-serine metabolic process (GO:0006563)2.55397111
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52847133
143regulation of mitotic spindle checkpoint (GO:1903504)2.52847133
144inner mitochondrial membrane organization (GO:0007007)2.50193185
145establishment of viral latency (GO:0019043)2.49874547
146intracellular protein transmembrane import (GO:0044743)2.49070856
147hydrogen ion transmembrane transport (GO:1902600)2.47205587
148DNA catabolic process, exonucleolytic (GO:0000738)2.47158706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.16971406
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25256125
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21854781
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.17233034
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.92691819
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.90135967
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.71514551
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.42952792
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.42395606
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40898352
11ZNF274_21170338_ChIP-Seq_K562_Hela3.28303110
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.14655218
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.11899713
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95861761
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.94460891
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88211859
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74286978
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.67796105
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66535197
20VDR_23849224_ChIP-Seq_CD4+_Human2.56510577
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.52588262
22E2F7_22180533_ChIP-Seq_HELA_Human2.51434761
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28528933
24DCP1A_22483619_ChIP-Seq_HELA_Human2.24336607
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22280885
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18917684
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.11644922
28FOXP3_21729870_ChIP-Seq_TREG_Human2.10445733
29XRN2_22483619_ChIP-Seq_HELA_Human2.09097394
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03334630
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96288506
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94090630
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89846727
34* GABP_19822575_ChIP-Seq_HepG2_Human1.89541781
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86093975
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83735839
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82458204
38* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79917013
39ELK1_19687146_ChIP-ChIP_HELA_Human1.79224535
40IGF1R_20145208_ChIP-Seq_DFB_Human1.74083768
41TTF2_22483619_ChIP-Seq_HELA_Human1.73146853
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65048394
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.64260960
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57060085
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56061641
46EWS_26573619_Chip-Seq_HEK293_Human1.52027097
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51643674
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50915210
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46022826
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45985293
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45862182
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42664074
53IRF1_19129219_ChIP-ChIP_H3396_Human1.41952222
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41857276
55FUS_26573619_Chip-Seq_HEK293_Human1.35284518
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34689590
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33652529
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30542521
59TP53_22573176_ChIP-Seq_HFKS_Human1.26942386
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25807420
61GBX2_23144817_ChIP-Seq_PC3_Human1.25406740
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22757556
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22375935
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21201704
65AR_21909140_ChIP-Seq_LNCAP_Human1.20553646
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19667969
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19386751
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.19284137
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19163891
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18205325
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17793252
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.15790054
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15601366
74SOX2_16153702_ChIP-ChIP_HESCs_Human1.15486386
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.15475127
76CIITA_25753668_ChIP-Seq_RAJI_Human1.13060779
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12975695
78P300_19829295_ChIP-Seq_ESCs_Human1.12731935
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12576584
80* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12179891
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11900487
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11601660
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09605153
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08929268
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08684192
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08378039
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.07447039
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05369682
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03018835
90TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00394703
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00064549
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97880034
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97331612
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96449776
95CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96169498
96* KDM5A_27292631_Chip-Seq_BREAST_Human0.95454752
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.95403574
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.91158310
99TAF15_26573619_Chip-Seq_HEK293_Human0.90373828
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90266039
101MYC_18940864_ChIP-ChIP_HL60_Human0.87773744
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.86423549
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86014208
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86014208
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86014208
106NCOR_22424771_ChIP-Seq_293T_Human0.84893857
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83426435
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82017453
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.81009105
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81009105
111STAT1_20625510_ChIP-Seq_HELA_Human0.80724652
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80438078
113ER_23166858_ChIP-Seq_MCF-7_Human0.80399367
114KLF5_20875108_ChIP-Seq_MESCs_Mouse0.80339161
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79652897
116VDR_22108803_ChIP-Seq_LS180_Human0.78234166
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77751435
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77664379
119CBP_20019798_ChIP-Seq_JUKART_Human0.77664379
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77394948
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76941025
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75862433
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75721434
124FLI1_27457419_Chip-Seq_LIVER_Mouse0.75138965
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74380385
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.73395353
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73337104
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73225013
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72681047
130SPI1_23547873_ChIP-Seq_NB4_Human0.72600333
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.72085476
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.71684335
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71124669
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70810872
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70804518
136NANOG_20526341_ChIP-Seq_ESCs_Human0.70616078
137CTCF_26484167_Chip-Seq_Bcells_Mouse0.70321641
138* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68545207
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68166009
140IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.68116023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.95110389
2MP0008877_abnormal_DNA_methylation4.27006174
3MP0006292_abnormal_olfactory_placode3.28769774
4MP0008057_abnormal_DNA_replication2.97265853
5MP0003693_abnormal_embryo_hatching2.89477100
6MP0001929_abnormal_gametogenesis2.79808202
7MP0001986_abnormal_taste_sensitivity2.74181983
8MP0003698_abnormal_male_reproductive2.67229487
9MP0008058_abnormal_DNA_repair2.54140536
10MP0002210_abnormal_sex_determination2.51527161
11MP0010094_abnormal_chromosome_stability2.50960833
12MP0001529_abnormal_vocalization2.41067830
13MP0004147_increased_porphyrin_level2.38212909
14MP0000920_abnormal_myelination2.35660769
15MP0008932_abnormal_embryonic_tissue2.31009383
16MP0003806_abnormal_nucleotide_metabolis2.29658266
17MP0003950_abnormal_plasma_membrane2.29032596
18MP0005394_taste/olfaction_phenotype2.23817697
19MP0005499_abnormal_olfactory_system2.23817697
20MP0001905_abnormal_dopamine_level2.22858065
21MP0008260_abnormal_autophagy2.15390719
22MP0000372_irregular_coat_pigmentation2.09307107
23MP0001145_abnormal_male_reproductive2.08283354
24MP0004957_abnormal_blastocyst_morpholog2.05998695
25MP0003077_abnormal_cell_cycle2.04846644
26MP0008007_abnormal_cellular_replicative2.03880361
27MP0003787_abnormal_imprinting2.01212046
28MP0003786_premature_aging1.97390546
29MP0002736_abnormal_nociception_after1.87055217
30MP0003011_delayed_dark_adaptation1.83849436
31MP0004133_heterotaxia1.83056443
32MP0000653_abnormal_sex_gland1.77075795
33MP0002160_abnormal_reproductive_system1.77005075
34MP0002837_dystrophic_cardiac_calcinosis1.76731176
35MP0006036_abnormal_mitochondrial_physio1.74156221
36MP0003111_abnormal_nucleus_morphology1.72870150
37MP0010030_abnormal_orbit_morphology1.69233130
38MP0003121_genomic_imprinting1.67352036
39MP0003186_abnormal_redox_activity1.66058974
40MP0001968_abnormal_touch/_nociception1.63873088
41MP0009046_muscle_twitch1.52420244
42MP0003656_abnormal_erythrocyte_physiolo1.52009117
43MP0000749_muscle_degeneration1.42388948
44MP0002161_abnormal_fertility/fecundity1.41987588
45MP0000049_abnormal_middle_ear1.41166528
46MP0000631_abnormal_neuroendocrine_gland1.34916936
47MP0002938_white_spotting1.34884496
48MP0003880_abnormal_central_pattern1.30715946
49MP0001984_abnormal_olfaction1.30086057
50MP0003122_maternal_imprinting1.29436086
51MP0003195_calcinosis1.27134062
52MP0002234_abnormal_pharynx_morphology1.26220799
53MP0000566_synostosis1.25005956
54MP0002735_abnormal_chemical_nociception1.21661235
55MP0009379_abnormal_foot_pigmentation1.21352336
56MP0003567_abnormal_fetal_cardiomyocyte1.20024060
57MP0002638_abnormal_pupillary_reflex1.18676868
58MP0008995_early_reproductive_senescence1.17993957
59MP0003937_abnormal_limbs/digits/tail_de1.17965569
60MP0008872_abnormal_physiological_respon1.17435883
61MP0003136_yellow_coat_color1.15927284
62MP0003646_muscle_fatigue1.15793616
63MP0003718_maternal_effect1.14093393
64MP0009333_abnormal_splenocyte_physiolog1.14093102
65MP0002751_abnormal_autonomic_nervous1.13741437
66MP0004134_abnormal_chest_morphology1.12979289
67MP0005646_abnormal_pituitary_gland1.12844199
68MP0003119_abnormal_digestive_system1.12291570
69MP0002132_abnormal_respiratory_system1.09087510
70MP0002653_abnormal_ependyma_morphology1.08290619
71MP0004036_abnormal_muscle_relaxation1.08110488
72MP0005171_absent_coat_pigmentation1.07783339
73MP0008875_abnormal_xenobiotic_pharmacok1.05953127
74MP0001485_abnormal_pinna_reflex1.05083760
75MP0001661_extended_life_span1.02881965
76MP0003938_abnormal_ear_development1.02830420
77MP0005084_abnormal_gallbladder_morpholo1.02016062
78MP0004270_analgesia1.01977431
79MP0001727_abnormal_embryo_implantation1.00754765
80MP0004142_abnormal_muscle_tone1.00552061
81MP0006035_abnormal_mitochondrial_morpho0.99550186
82MP0000778_abnormal_nervous_system0.99174123
83MP0002233_abnormal_nose_morphology0.98843521
84MP0000516_abnormal_urinary_system0.98736785
85MP0005367_renal/urinary_system_phenotyp0.98736785
86MP0001730_embryonic_growth_arrest0.97831258
87MP0005075_abnormal_melanosome_morpholog0.97583490
88MP0005391_vision/eye_phenotype0.96835093
89MP0001486_abnormal_startle_reflex0.92740745
90MP0002822_catalepsy0.92523617
91MP0009745_abnormal_behavioral_response0.91377813
92MP0006276_abnormal_autonomic_nervous0.90947004
93MP0003315_abnormal_perineum_morphology0.89885404
94MP0005671_abnormal_response_to0.88136716
95MP0002090_abnormal_vision0.86895169
96MP0000026_abnormal_inner_ear0.85107135
97MP0001286_abnormal_eye_development0.84629220
98MP0002229_neurodegeneration0.83660577
99MP0002557_abnormal_social/conspecific_i0.83032789
100MP0005645_abnormal_hypothalamus_physiol0.82809184
101MP0005389_reproductive_system_phenotype0.82210959
102MP0004145_abnormal_muscle_electrophysio0.81212933
103MP0002396_abnormal_hematopoietic_system0.81112093
104MP0000358_abnormal_cell_content/0.80841524
105MP0006072_abnormal_retinal_apoptosis0.80540850
106MP0005253_abnormal_eye_physiology0.80329613
107MP0002282_abnormal_trachea_morphology0.80138536
108MP0002734_abnormal_mechanical_nocicepti0.78253871
109MP0001764_abnormal_homeostasis0.78124384
110MP0003890_abnormal_embryonic-extraembry0.77870801
111MP0001293_anophthalmia0.77670571
112MP0003634_abnormal_glial_cell0.77437808
113MP0005386_behavior/neurological_phenoty0.76555077
114MP0004924_abnormal_behavior0.76555077
115MP0002277_abnormal_respiratory_mucosa0.75323470
116MP0003755_abnormal_palate_morphology0.75074189
117MP0005195_abnormal_posterior_eye0.75016769
118MP0001919_abnormal_reproductive_system0.74228866
119MP0005408_hypopigmentation0.73344892
120* MP0000313_abnormal_cell_death0.73058473
121MP0004084_abnormal_cardiac_muscle0.69607080
122MP0001970_abnormal_pain_threshold0.66545467
123MP0002163_abnormal_gland_morphology0.66200946
124MP0000747_muscle_weakness0.66107124
125MP0005551_abnormal_eye_electrophysiolog0.65849198
126MP0005409_darkened_coat_color0.65727557
127MP0004043_abnormal_pH_regulation0.64827022
128MP0005330_cardiomyopathy0.64615643
129MP0002272_abnormal_nervous_system0.64488706
130MP0003221_abnormal_cardiomyocyte_apopto0.61987334
131MP0004742_abnormal_vestibular_system0.61467510
132MP0002102_abnormal_ear_morphology0.61462382
133MP0002752_abnormal_somatic_nervous0.60858152
134MP0008789_abnormal_olfactory_epithelium0.60170564
135MP0000647_abnormal_sebaceous_gland0.59525678
136MP0000751_myopathy0.58731350
137MP0009840_abnormal_foam_cell0.58365900
138MP0009697_abnormal_copulation0.58234889
139MP0002095_abnormal_skin_pigmentation0.57953028
140MP0003329_amyloid_beta_deposits0.57560497
141MP0001542_abnormal_bone_strength0.56118245
142MP0001697_abnormal_embryo_size0.55187329
143MP0004215_abnormal_myocardial_fiber0.53991285
144MP0003763_abnormal_thymus_physiology0.53348078
145MP0003632_abnormal_nervous_system0.52469806
146MP0003137_abnormal_impulse_conducting0.51406488
147MP0003878_abnormal_ear_physiology0.51389541
148MP0005377_hearing/vestibular/ear_phenot0.51389541

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.53878985
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.52803142
3Increased serum pyruvate (HP:0003542)4.24044960
4Abnormality of glycolysis (HP:0004366)4.24044960
5Cerebral hypomyelination (HP:0006808)4.15340145
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.07822802
7Absent/shortened dynein arms (HP:0200106)4.07822802
8Mitochondrial inheritance (HP:0001427)4.04519120
9Abnormal mitochondria in muscle tissue (HP:0008316)3.97761904
10Hepatocellular necrosis (HP:0001404)3.89099374
11Acute encephalopathy (HP:0006846)3.60125988
12Abnormal respiratory epithelium morphology (HP:0012253)3.52523388
13Abnormal respiratory motile cilium morphology (HP:0005938)3.52523388
14Hepatic necrosis (HP:0002605)3.49523038
15Progressive macrocephaly (HP:0004481)3.48521178
16Increased CSF lactate (HP:0002490)3.48146335
17Increased hepatocellular lipid droplets (HP:0006565)3.29834332
183-Methylglutaconic aciduria (HP:0003535)3.21160668
19Abnormality of cells of the erythroid lineage (HP:0012130)3.16741086
20Abnormal number of erythroid precursors (HP:0012131)3.12171895
21True hermaphroditism (HP:0010459)3.07147860
22Abnormal respiratory motile cilium physiology (HP:0012261)3.04774228
23Lipid accumulation in hepatocytes (HP:0006561)3.03175146
24Gonadotropin excess (HP:0000837)2.97450045
25Hypothermia (HP:0002045)2.90239956
26Renal Fanconi syndrome (HP:0001994)2.87794847
27Leukodystrophy (HP:0002415)2.86234654
28Rhinitis (HP:0012384)2.74073864
29Increased serum lactate (HP:0002151)2.70150349
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68285081
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68285081
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65686649
33Hypoplasia of the capital femoral epiphysis (HP:0003090)2.64537019
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.63902653
35Renal cortical cysts (HP:0000803)2.62043371
36Reticulocytopenia (HP:0001896)2.55896060
37Respiratory failure (HP:0002878)2.54568600
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54344077
39Congenital primary aphakia (HP:0007707)2.50442444
40Gait imbalance (HP:0002141)2.50157732
41Poor suck (HP:0002033)2.47237594
42Degeneration of anterior horn cells (HP:0002398)2.45226592
43Abnormality of the anterior horn cell (HP:0006802)2.45226592
44Lactic acidosis (HP:0003128)2.45062650
45Nephrogenic diabetes insipidus (HP:0009806)2.43212084
46Exercise intolerance (HP:0003546)2.42986650
47Abnormality of the labia minora (HP:0012880)2.42496220
48Abnormal ciliary motility (HP:0012262)2.40677443
49Abnormal spermatogenesis (HP:0008669)2.39320284
50CNS hypomyelination (HP:0003429)2.39065727
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.38951186
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38951186
53Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.38494215
54Absent epiphyses (HP:0010577)2.38494215
55Exertional dyspnea (HP:0002875)2.37575944
56Abnormality of alanine metabolism (HP:0010916)2.36958516
57Hyperalaninemia (HP:0003348)2.36958516
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36958516
59Sclerocornea (HP:0000647)2.35247795
60Optic disc pallor (HP:0000543)2.30520879
61Colon cancer (HP:0003003)2.27590885
62Abnormality of the renal cortex (HP:0011035)2.26666305
63Neuroendocrine neoplasm (HP:0100634)2.26342880
64Parakeratosis (HP:0001036)2.25797662
65Chronic bronchitis (HP:0004469)2.25497097
66Increased intramyocellular lipid droplets (HP:0012240)2.24376968
67Cerebral edema (HP:0002181)2.22954237
68Abnormality of renal resorption (HP:0011038)2.22072187
69Type I transferrin isoform profile (HP:0003642)2.21677624
70Congenital stationary night blindness (HP:0007642)2.21452229
71Respiratory difficulties (HP:0002880)2.17489386
72Type 2 muscle fiber atrophy (HP:0003554)2.17077879
73Hyperglycinemia (HP:0002154)2.16389144
74Abnormality of the renal medulla (HP:0100957)2.15805513
75Pendular nystagmus (HP:0012043)2.15315251
76Retinal dysplasia (HP:0007973)2.15102940
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.14939819
78Medial flaring of the eyebrow (HP:0010747)2.14008859
79Irregular epiphyses (HP:0010582)2.12929161
80Nephronophthisis (HP:0000090)2.12471003
81Hyperventilation (HP:0002883)2.11057756
82Attenuation of retinal blood vessels (HP:0007843)2.10584188
83Duplicated collecting system (HP:0000081)2.09826633
84Pheochromocytoma (HP:0002666)2.09290550
85Optic nerve hypoplasia (HP:0000609)2.08800345
86Calf muscle hypertrophy (HP:0008981)2.08742246
87Pancytopenia (HP:0001876)2.08285716
88Concave nail (HP:0001598)2.07880682
89Abnormal rod and cone electroretinograms (HP:0008323)2.07051197
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06984717
91Abnormal biliary tract physiology (HP:0012439)2.04819716
92Bile duct proliferation (HP:0001408)2.04819716
93Increased muscle lipid content (HP:0009058)2.03611858
94Genital tract atresia (HP:0001827)2.02784818
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.02277091
96Birth length less than 3rd percentile (HP:0003561)2.01916956
97Macrocytic anemia (HP:0001972)2.01002569
98Postnatal microcephaly (HP:0005484)2.00612406
99Carpal bone hypoplasia (HP:0001498)2.00591487
100Aplastic anemia (HP:0001915)2.00287261
101Emotional lability (HP:0000712)1.99570620
102Vaginal atresia (HP:0000148)1.99221958
103Autoamputation (HP:0001218)1.97492818
104Anencephaly (HP:0002323)1.95284838
105Type II lissencephaly (HP:0007260)1.95081442
106Abnormality of the renal collecting system (HP:0004742)1.91836903
107Methylmalonic acidemia (HP:0002912)1.89179971
108Methylmalonic aciduria (HP:0012120)1.88231489
109Lethargy (HP:0001254)1.88016414
110Impulsivity (HP:0100710)1.87959382
111Secondary amenorrhea (HP:0000869)1.87766123
112Exercise-induced muscle cramps (HP:0003710)1.86677549
113Short tibia (HP:0005736)1.85466031
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.84601894
115Rough bone trabeculation (HP:0100670)1.84454901
116CNS demyelination (HP:0007305)1.83351951
117Hypoplasia of the fovea (HP:0007750)1.82584324
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.82584324
119Muscle fiber splitting (HP:0003555)1.82529717
120Muscle fiber atrophy (HP:0100295)1.81973238
121Segmental peripheral demyelination/remyelination (HP:0003481)1.81594944
122Microvesicular hepatic steatosis (HP:0001414)1.81352517
123Pancreatic fibrosis (HP:0100732)1.81078513
124Absent septum pellucidum (HP:0001331)1.80221065
125Intestinal atresia (HP:0011100)1.79801934
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79494254
127Abnormal protein N-linked glycosylation (HP:0012347)1.79494254
128Abnormal protein glycosylation (HP:0012346)1.79494254
129Abnormal glycosylation (HP:0012345)1.79494254
130Molar tooth sign on MRI (HP:0002419)1.79415285
131Abnormality of midbrain morphology (HP:0002418)1.79415285
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.77159934
133Meckel diverticulum (HP:0002245)1.76845705
134Tubulointerstitial nephritis (HP:0001970)1.76548454
135X-linked dominant inheritance (HP:0001423)1.76545169
136Hepatosplenomegaly (HP:0001433)1.76408610
137Breast hypoplasia (HP:0003187)1.76286275
138Abnormality of the ileum (HP:0001549)1.74836266
139Tubular atrophy (HP:0000092)1.74514453
140Muscle hypertrophy of the lower extremities (HP:0008968)1.74306917
141Infertility (HP:0000789)1.74235361
142Azoospermia (HP:0000027)1.74057084
143Hyperglycinuria (HP:0003108)1.73290263
144Abnormality of the septum pellucidum (HP:0007375)1.73004127
145Male pseudohermaphroditism (HP:0000037)1.72902096
146Congenital ichthyosiform erythroderma (HP:0007431)1.71995625
147Poor coordination (HP:0002370)1.71012864
148Abnormality of serine family amino acid metabolism (HP:0010894)1.70438040
149Abnormality of glycine metabolism (HP:0010895)1.70438040
15011 pairs of ribs (HP:0000878)1.69971264
151Abolished electroretinogram (ERG) (HP:0000550)1.69789372
152Inability to walk (HP:0002540)1.69758739
153Preaxial hand polydactyly (HP:0001177)1.69612578
154Aplasia/hypoplasia of the uterus (HP:0008684)1.69149064
155Pancreatic cysts (HP:0001737)1.68842872
156Upper limb muscle weakness (HP:0003484)1.67535945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.30558431
2STK393.69207659
3PDK43.68664539
4PDK33.68664539
5VRK23.49322282
6STK163.36483263
7PBK2.71096133
8EIF2AK12.61187501
9WEE12.56504782
10TESK12.42126020
11MAP4K22.37704286
12WNK32.31015027
13PDK22.29035480
14TESK22.27502056
15TRIM282.21596759
16NME22.17699327
17LIMK12.13208171
18NUAK12.12135938
19WNK42.08052309
20MAP3K41.96046664
21CDK81.89004939
22BRSK21.84471283
23SRPK11.78825844
24MAPKAPK51.78521862
25FRK1.76660119
26EIF2AK31.68283684
27MAP2K71.67435612
28VRK11.66758948
29PNCK1.57609990
30MST41.57155427
31CDC71.50034412
32CASK1.50000871
33OXSR11.46788037
34NEK11.36743809
35PIM21.32942714
36PLK41.31148048
37TLK11.28550087
38GRK11.27957264
39BCR1.27587422
40DYRK31.26797253
41CDK191.24859439
42CSNK1G31.22246387
43BMPR1B1.22093921
44MKNK11.20246824
45DYRK21.19508611
46MUSK1.16783087
47CCNB11.10911477
48EPHA41.07382647
49TAF11.07036556
50TSSK61.03780638
51MARK11.03717010
52PLK20.97221892
53BCKDK0.95685884
54ARAF0.95534290
55RPS6KA50.94863498
56NEK20.94146437
57ACVR1B0.93419001
58EPHB10.90692258
59PASK0.89662403
60INSRR0.88601135
61BRAF0.85479336
62PLK10.84910214
63TNIK0.82373781
64OBSCN0.82228982
65ERBB30.80819592
66GRK70.80531433
67STK38L0.80300510
68CSNK1G10.79645370
69PRKCG0.77432493
70MYLK0.76668978
71ERBB40.75570423
72BRSK10.75567379
73WNK10.73952541
74PKN10.73706063
75NTRK10.73201815
76ADRBK20.72225134
77YES10.71698333
78AURKA0.71666622
79CSNK1A1L0.70322448
80PINK10.67260923
81EIF2AK20.66309936
82ATR0.65663028
83NME10.64361268
84PRKCE0.63779313
85PAK30.62719909
86MAP3K120.61740187
87PAK10.61012922
88KDR0.60754642
89EPHB20.60260181
90TTK0.60065384
91PRPF4B0.59646461
92PAK60.59576849
93BLK0.58246098
94TEC0.57760224
95MET0.56372097
96PRKCI0.56258401
97UHMK10.55993228
98PLK30.53729111
99CSNK2A10.52657875
100CHEK20.52570354
101CSNK1A10.52126738
102MKNK20.51679123
103DAPK10.49985809
104MINK10.49972232
105AURKB0.49807570
106MAPK150.47781307
107TGFBR10.46517183
108CSNK2A20.46073263
109STK40.45579099
110CSNK1G20.45162219
111ICK0.44753964
112IRAK10.44400515
113ZAK0.44228400
114CLK10.43981574
115ATM0.42311761
116MAPK130.41202477
117CDK70.40846170
118CAMK2B0.40823691
119PTK2B0.40653821
120CHEK10.40284207
121CSNK1D0.40106705
122PHKG20.40022972
123PHKG10.40022972
124TIE10.40020046
125PRKACB0.39510333
126CAMK2A0.38914155
127DAPK30.36940078
128FLT30.36630433
129DYRK1B0.36034629
130ADRBK10.35919522
131CAMK2G0.34772032
132NEK60.34261403
133CAMK2D0.33838520
134ILK0.32996527
135NLK0.32401124
136ROCK20.32130030
137MAP2K20.31032292
138MATK0.27994568
139IRAK20.27717242
140RPS6KB20.26855863

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.51691466
2RNA polymerase_Homo sapiens_hsa030203.51753103
3Ribosome_Homo sapiens_hsa030103.35701468
4Oxidative phosphorylation_Homo sapiens_hsa001903.12563960
5Parkinsons disease_Homo sapiens_hsa050122.95298741
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.93939612
7DNA replication_Homo sapiens_hsa030302.85732443
8Protein export_Homo sapiens_hsa030602.81841255
9Fatty acid elongation_Homo sapiens_hsa000622.66078966
10Mismatch repair_Homo sapiens_hsa034302.56005600
11Homologous recombination_Homo sapiens_hsa034402.41484846
12Basal transcription factors_Homo sapiens_hsa030222.40895087
13Huntingtons disease_Homo sapiens_hsa050162.38363037
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29242951
15Pyrimidine metabolism_Homo sapiens_hsa002402.19036017
16Spliceosome_Homo sapiens_hsa030402.14668571
17Vitamin B6 metabolism_Homo sapiens_hsa007502.04201692
18Nucleotide excision repair_Homo sapiens_hsa034202.02268377
19Alzheimers disease_Homo sapiens_hsa050101.89470087
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87349755
21RNA transport_Homo sapiens_hsa030131.81351278
22Base excision repair_Homo sapiens_hsa034101.79089266
23Steroid biosynthesis_Homo sapiens_hsa001001.76583875
24Fanconi anemia pathway_Homo sapiens_hsa034601.60864584
25Non-homologous end-joining_Homo sapiens_hsa034501.59299034
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.55141489
27Purine metabolism_Homo sapiens_hsa002301.49396554
28Ether lipid metabolism_Homo sapiens_hsa005651.39154590
29Folate biosynthesis_Homo sapiens_hsa007901.31719301
30RNA degradation_Homo sapiens_hsa030181.29784065
31Butanoate metabolism_Homo sapiens_hsa006501.27458055
32Cell cycle_Homo sapiens_hsa041101.27200068
33Linoleic acid metabolism_Homo sapiens_hsa005911.25504352
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23779461
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23663573
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20995040
37Cardiac muscle contraction_Homo sapiens_hsa042601.19681813
38Propanoate metabolism_Homo sapiens_hsa006401.19219984
39Pyruvate metabolism_Homo sapiens_hsa006201.18572539
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13467165
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.13267340
42Regulation of autophagy_Homo sapiens_hsa041401.12363733
43Tryptophan metabolism_Homo sapiens_hsa003801.11896180
44Pentose phosphate pathway_Homo sapiens_hsa000301.10024162
45Glutathione metabolism_Homo sapiens_hsa004801.03165190
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01944814
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01911553
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95127996
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93984987
50Sphingolipid metabolism_Homo sapiens_hsa006000.91936571
51Sulfur relay system_Homo sapiens_hsa041220.91875475
52Arachidonic acid metabolism_Homo sapiens_hsa005900.91115618
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87459921
54beta-Alanine metabolism_Homo sapiens_hsa004100.86744231
55Epstein-Barr virus infection_Homo sapiens_hsa051690.84936819
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.81825590
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.81772583
58Metabolic pathways_Homo sapiens_hsa011000.80231374
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79826544
60Nitrogen metabolism_Homo sapiens_hsa009100.75481034
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75167065
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73251810
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71451343
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71059458
65Nicotine addiction_Homo sapiens_hsa050330.67648767
66mRNA surveillance pathway_Homo sapiens_hsa030150.65753909
67Selenocompound metabolism_Homo sapiens_hsa004500.63170089
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.63122659
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62411282
70One carbon pool by folate_Homo sapiens_hsa006700.59197716
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55545696
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55542779
73Systemic lupus erythematosus_Homo sapiens_hsa053220.52587983
74Carbon metabolism_Homo sapiens_hsa012000.52271559
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51310490
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50894536
77Arginine and proline metabolism_Homo sapiens_hsa003300.50575939
78Caffeine metabolism_Homo sapiens_hsa002320.49752063
79Oocyte meiosis_Homo sapiens_hsa041140.48079140
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47795290
81Autoimmune thyroid disease_Homo sapiens_hsa053200.47746094
82Allograft rejection_Homo sapiens_hsa053300.47561296
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.43473763
84Taste transduction_Homo sapiens_hsa047420.43067227
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42794469
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41106826
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.40537421
88Chemical carcinogenesis_Homo sapiens_hsa052040.40232038
89Fatty acid metabolism_Homo sapiens_hsa012120.39713723
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.37680081
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37430008
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37122406
93Peroxisome_Homo sapiens_hsa041460.36969067
94Fatty acid degradation_Homo sapiens_hsa000710.36840932
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36503327
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36331265
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35210755
98Basal cell carcinoma_Homo sapiens_hsa052170.34356721
99Hedgehog signaling pathway_Homo sapiens_hsa043400.33092829
100Asthma_Homo sapiens_hsa053100.32950104
101N-Glycan biosynthesis_Homo sapiens_hsa005100.32132115
102Biosynthesis of amino acids_Homo sapiens_hsa012300.31732276
103p53 signaling pathway_Homo sapiens_hsa041150.31628340
104Fat digestion and absorption_Homo sapiens_hsa049750.31146548
105Primary immunodeficiency_Homo sapiens_hsa053400.30592025
106Histidine metabolism_Homo sapiens_hsa003400.30541040
107Antigen processing and presentation_Homo sapiens_hsa046120.30491680
108Legionellosis_Homo sapiens_hsa051340.29032078
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25844882
110Herpes simplex infection_Homo sapiens_hsa051680.24540775
111Alcoholism_Homo sapiens_hsa050340.21705670
112Tyrosine metabolism_Homo sapiens_hsa003500.20955767
113Sulfur metabolism_Homo sapiens_hsa009200.20584302
114Rheumatoid arthritis_Homo sapiens_hsa053230.20418898
115Vitamin digestion and absorption_Homo sapiens_hsa049770.20218204
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17867320
117Viral carcinogenesis_Homo sapiens_hsa052030.16232743
118Hematopoietic cell lineage_Homo sapiens_hsa046400.15862023
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.15666315
120Other glycan degradation_Homo sapiens_hsa005110.13208078
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12435373
122Fructose and mannose metabolism_Homo sapiens_hsa000510.11729168
123Vibrio cholerae infection_Homo sapiens_hsa051100.11687167
124Phagosome_Homo sapiens_hsa041450.10872578
125Retinol metabolism_Homo sapiens_hsa008300.07996860
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06287793
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05859789
128Phototransduction_Homo sapiens_hsa047440.04911092
129Collecting duct acid secretion_Homo sapiens_hsa049660.04337764

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