DHX38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.94464634
2nuclear pore organization (GO:0006999)4.77245333
3DNA unwinding involved in DNA replication (GO:0006268)4.41687455
4protein localization to kinetochore (GO:0034501)4.15750512
5negative regulation of erythrocyte differentiation (GO:0045647)4.00570579
6heterochromatin organization (GO:0070828)3.92135426
7COPI coating of Golgi vesicle (GO:0048205)3.87088297
8Golgi transport vesicle coating (GO:0048200)3.87088297
9regulation of histone H3-K27 methylation (GO:0061085)3.86769119
10mitotic nuclear envelope disassembly (GO:0007077)3.81184952
11pore complex assembly (GO:0046931)3.76458552
12folic acid-containing compound biosynthetic process (GO:0009396)3.68846028
13regulation of translational fidelity (GO:0006450)3.63186026
14pre-miRNA processing (GO:0031054)3.63120884
15dosage compensation (GO:0007549)3.61119377
16protein localization to endosome (GO:0036010)3.59634902
17nuclear envelope disassembly (GO:0051081)3.58129824
18membrane disassembly (GO:0030397)3.58129824
19protein localization to chromosome, centromeric region (GO:0071459)3.45181968
20DNA duplex unwinding (GO:0032508)3.42545083
21mannose metabolic process (GO:0006013)3.41157808
22mitotic chromosome condensation (GO:0007076)3.40295097
23DNA geometric change (GO:0032392)3.40179417
24regulation of translational termination (GO:0006449)3.39043255
25RNA stabilization (GO:0043489)3.30641852
26mRNA stabilization (GO:0048255)3.30641852
27embryonic process involved in female pregnancy (GO:0060136)3.28355697
28negative regulation of histone methylation (GO:0031061)3.22789798
29IMP biosynthetic process (GO:0006188)3.20528307
30cell-substrate adherens junction assembly (GO:0007045)3.17818781
31focal adhesion assembly (GO:0048041)3.17818781
32regulation of histone H3-K9 methylation (GO:0051570)3.17731788
33adherens junction assembly (GO:0034333)3.15926452
34histone H3-K36 demethylation (GO:0070544)3.13795808
35sister chromatid segregation (GO:0000819)3.10809487
36regulation of NFAT protein import into nucleus (GO:0051532)3.10355232
37regulation of posttranscriptional gene silencing (GO:0060147)3.08080967
38regulation of gene silencing by miRNA (GO:0060964)3.08080967
39regulation of gene silencing by RNA (GO:0060966)3.08080967
40pinocytosis (GO:0006907)3.05679420
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.05274342
42chromatin assembly (GO:0031497)3.03730230
43mitotic sister chromatid segregation (GO:0000070)2.99914222
443-UTR-mediated mRNA stabilization (GO:0070935)2.98214701
45DNA replication-dependent nucleosome assembly (GO:0006335)2.98002002
46DNA replication-dependent nucleosome organization (GO:0034723)2.98002002
47mitotic sister chromatid cohesion (GO:0007064)2.96882821
48regulation of early endosome to late endosome transport (GO:2000641)2.90956056
49NIK/NF-kappaB signaling (GO:0038061)2.90430854
50nuclear envelope organization (GO:0006998)2.90409410
51activation of Rac GTPase activity (GO:0032863)2.86265117
52DNA replication initiation (GO:0006270)2.83837591
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.83361864
54DNA strand elongation involved in DNA replication (GO:0006271)2.83227694
55peptidyl-lysine dimethylation (GO:0018027)2.82689875
56formation of translation preinitiation complex (GO:0001731)2.82103377
57response to muramyl dipeptide (GO:0032495)2.81975818
58stress fiber assembly (GO:0043149)2.81870833
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80604767
60IMP metabolic process (GO:0046040)2.80126497
61positive regulation of SMAD protein import into nucleus (GO:0060391)2.79631768
62cell-substrate junction assembly (GO:0007044)2.77880700
63regulation of glucose import in response to insulin stimulus (GO:2001273)2.76613670
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76476415
65regulation of spindle organization (GO:0090224)2.75660429
66regulation of RNA export from nucleus (GO:0046831)2.75523587
67modulation by symbiont of host cellular process (GO:0044068)2.75361909
68activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74838586
69regulation of mitotic spindle organization (GO:0060236)2.74764460
70positive regulation of chromosome segregation (GO:0051984)2.72363864
71DNA conformation change (GO:0071103)2.71491444
72NLS-bearing protein import into nucleus (GO:0006607)2.69904186
73positive regulation of histone deacetylation (GO:0031065)2.69739355
74positive regulation of nuclease activity (GO:0032075)2.67832855
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.67795682
76spliceosomal tri-snRNP complex assembly (GO:0000244)2.66871433
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66580063
78regulation of protein heterodimerization activity (GO:0043497)2.65973158
79translesion synthesis (GO:0019985)2.65904996
80DNA strand elongation (GO:0022616)2.64596236
81histone H3-K9 demethylation (GO:0033169)2.64470666
82histone H2A monoubiquitination (GO:0035518)2.63243693
83negative regulation of cell size (GO:0045792)2.62673456
84chromosome condensation (GO:0030261)2.60202025
85DNA replication checkpoint (GO:0000076)2.56851883
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.55797395
87mitotic metaphase plate congression (GO:0007080)2.54566370
88mitotic G1 DNA damage checkpoint (GO:0031571)2.54478261
89glucocorticoid receptor signaling pathway (GO:0042921)2.54325431
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.54243407
91histone lysine demethylation (GO:0070076)2.51845679
92regulation of mRNA stability (GO:0043488)2.51631055
93cellular response to epidermal growth factor stimulus (GO:0071364)2.50234145
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.49841052
95trophectodermal cell differentiation (GO:0001829)2.49825115
96apoptotic process involved in morphogenesis (GO:0060561)2.49287775
97histone mRNA catabolic process (GO:0071044)2.49203842
98regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48852556
99regulation of sister chromatid cohesion (GO:0007063)2.48715925
100thymic T cell selection (GO:0045061)2.47638059
101modulation by virus of host process (GO:0019054)2.46939445
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.46837324
103protein localization to chromosome (GO:0034502)2.45266111
104nucleobase biosynthetic process (GO:0046112)2.45169483
105histone demethylation (GO:0016577)2.44942846
106gene silencing by RNA (GO:0031047)2.44642461
107positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.44522194
108cellular hyperosmotic response (GO:0071474)2.44352175
109endoplasmic reticulum unfolded protein response (GO:0030968)2.44269045
110regulation of nuclease activity (GO:0032069)2.44210151
111regulation of SMAD protein import into nucleus (GO:0060390)2.44006020
112negative regulation of viral release from host cell (GO:1902187)2.43310904
113T cell apoptotic process (GO:0070231)2.43168517
114positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.42844016
115regulation of chromatin binding (GO:0035561)2.42683088
116pentose-phosphate shunt (GO:0006098)2.42233388
117regulation of RNA stability (GO:0043487)2.41951091
118basement membrane organization (GO:0071711)2.41920421
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41595366
120chromatin assembly or disassembly (GO:0006333)2.41232391
121negative regulation of RNA splicing (GO:0033119)2.40684902
122positive regulation of extracellular matrix organization (GO:1903055)2.39259128
123protein export from nucleus (GO:0006611)2.39196651
124germinal center formation (GO:0002467)2.38271467
125proline biosynthetic process (GO:0006561)2.38240073
126positive thymic T cell selection (GO:0045059)2.38151517
127gene silencing (GO:0016458)2.37981894
128barbed-end actin filament capping (GO:0051016)2.37644288
129response to laminar fluid shear stress (GO:0034616)2.37333932
130glucose 6-phosphate metabolic process (GO:0051156)2.37305514
131regulation of necroptotic process (GO:0060544)2.36640841
132regulation of extracellular matrix disassembly (GO:0010715)2.35913104
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35572557
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35572557
135response to UV-C (GO:0010225)2.35217741
136ER-nucleus signaling pathway (GO:0006984)2.35004454
137protein retention in ER lumen (GO:0006621)2.34669298
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.34146324
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.34146324
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.34146324
141activation of MAPKKK activity (GO:0000185)2.33516658
142negative regulation of necroptotic process (GO:0060546)2.32913577
143spindle assembly involved in mitosis (GO:0090307)2.32121210
144response to epidermal growth factor (GO:0070849)2.31421941
145positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31085915
146alternative mRNA splicing, via spliceosome (GO:0000380)2.31016926
147positive regulation of protein import into nucleus, translocation (GO:0033160)2.30708793
148skin morphogenesis (GO:0043589)2.30279784
149regulation of gamma-delta T cell differentiation (GO:0045586)2.30181430
150response to peptidoglycan (GO:0032494)2.30165192
151regulation of interleukin-12 biosynthetic process (GO:0045075)2.28735941
152negative regulation of histone modification (GO:0031057)2.28669932
153cellular response to virus (GO:0098586)2.28444035
154mitotic G1/S transition checkpoint (GO:0044819)2.27783225
155regulation of hippo signaling (GO:0035330)2.27607976
156intracellular estrogen receptor signaling pathway (GO:0030520)2.27562387
157modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.26807611
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.26807611
159modulation by symbiont of host immune response (GO:0052553)2.26807611
160positive regulation by symbiont of host defense response (GO:0052509)2.26807611
161modulation by symbiont of host defense response (GO:0052031)2.26807611
162modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26807611
163positive regulation of gamma-delta T cell activation (GO:0046645)2.26352544
164negative regulation of fatty acid transport (GO:2000192)2.25862386
165maternal placenta development (GO:0001893)2.25810385
166* mRNA transport (GO:0051028)2.25628237
167corticosteroid receptor signaling pathway (GO:0031958)2.24933528
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24830373
169positive regulation of protein deacetylation (GO:0090312)2.24573003
170DNA topological change (GO:0006265)2.23733686
171regulation of cholesterol homeostasis (GO:2000188)2.23694418
172histone H4 deacetylation (GO:0070933)2.23385309
173regulation of gene silencing (GO:0060968)2.22699647
174telomere maintenance via semi-conservative replication (GO:0032201)2.22680355
175regulation of integrin activation (GO:0033623)2.21907711
176regulation of nucleobase-containing compound transport (GO:0032239)2.21770975
177cellular response to unfolded protein (GO:0034620)2.21673966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93754495
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.49290430
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.80590689
4MYC_22102868_ChIP-Seq_BL_Human3.17256798
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98732405
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.83062563
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72397760
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.44726837
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34984875
10VDR_21846776_ChIP-Seq_THP-1_Human2.29068903
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05759049
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01283962
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87829536
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83920323
15TCF7_22412390_ChIP-Seq_EML_Mouse1.74096282
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.73683718
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69647677
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64062360
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61480687
20AR_21909140_ChIP-Seq_LNCAP_Human1.61294288
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60478010
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58867587
23NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54949256
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.54795703
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54404439
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53931457
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.53026417
28KDM2B_26808549_Chip-Seq_K562_Human1.51832239
29MAF_26560356_Chip-Seq_TH1_Human1.51492232
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50650776
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50171632
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49353611
33UTX_26944678_Chip-Seq_JUKART_Human1.49198338
34XRN2_22483619_ChIP-Seq_HELA_Human1.49158121
35CIITA_25753668_ChIP-Seq_RAJI_Human1.46474526
36KDM2B_26808549_Chip-Seq_DND41_Human1.46186954
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45509329
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.43745700
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40481211
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38633700
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37764088
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37529539
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36963530
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.36484710
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35844757
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35320670
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34652750
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34362322
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33913668
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33649412
51TFEB_21752829_ChIP-Seq_HELA_Human1.31675200
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28019556
53VDR_24763502_ChIP-Seq_THP-1_Human1.26377539
54KDM5A_27292631_Chip-Seq_BREAST_Human1.26376505
55CLOCK_20551151_ChIP-Seq_293T_Human1.25351307
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25142976
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25071936
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.24973687
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24702786
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23283048
61* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23153814
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23108986
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22702636
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.22554735
65MYB_26560356_Chip-Seq_TH1_Human1.22013397
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21565493
67MYB_26560356_Chip-Seq_TH2_Human1.21097107
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21082394
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20773035
70IRF8_21731497_ChIP-ChIP_J774_Mouse1.20552927
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19394440
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19178001
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18590697
74* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18189699
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.16995621
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16975014
77HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16939433
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15442370
79P68_20966046_ChIP-Seq_HELA_Human1.15402603
80NCOR1_26117541_ChIP-Seq_K562_Human1.14524946
81ATF3_27146783_Chip-Seq_COLON_Human1.13949476
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13814508
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13694989
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12545143
85SMC4_20622854_ChIP-Seq_HELA_Human1.12497328
86SPI1_23547873_ChIP-Seq_NB4_Human1.11422063
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11139540
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.10423672
89SPI1_23127762_ChIP-Seq_K562_Human1.09741440
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09670514
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09182343
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09083977
93* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08771422
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08454393
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08374202
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07209230
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.07168955
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06783983
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06161465
100TP53_22127205_ChIP-Seq_IMR90_Human1.06068370
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05956138
102CREB1_26743006_Chip-Seq_LNCaP_Human1.05657842
103MAF_26560356_Chip-Seq_TH2_Human1.05519596
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04888583
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04858065
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03814416
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.03747889
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03188593
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.02989895
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02465713
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.02368734
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01505768
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.01497501
114ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00512569
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00234095
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98543095
117ZNF263_19887448_ChIP-Seq_K562_Human0.98504478
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98229260
119IRF8_27001747_Chip-Seq_BMDM_Mouse0.97473824
120SCL_19346495_ChIP-Seq_HPC-7_Human0.97290233
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96761013
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96709566
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95391319
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94793583
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94455931
126* ETS1_20019798_ChIP-Seq_JURKAT_Human0.93807505
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93783178
128RACK7_27058665_Chip-Seq_MCF-7_Human0.93230647
129CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92782265
130GABP_19822575_ChIP-Seq_HepG2_Human0.91181502
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90836485
132TTF2_22483619_ChIP-Seq_HELA_Human0.90764494
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90096216
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90049836
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89189688
136* FOXP3_21729870_ChIP-Seq_TREG_Human0.88742700
137SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88533765
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88160565
139LXR_22292898_ChIP-Seq_THP-1_Human0.88029115
140E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87368165
141STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87240444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.57409972
2MP0010352_gastrointestinal_tract_polyps3.44065031
3MP0003705_abnormal_hypodermis_morpholog3.13708709
4MP0005076_abnormal_cell_differentiation2.89104937
5MP0003111_abnormal_nucleus_morphology2.73762631
6MP0003693_abnormal_embryo_hatching2.58547066
7MP0010094_abnormal_chromosome_stability2.55726645
8MP0010307_abnormal_tumor_latency2.49543383
9MP0003077_abnormal_cell_cycle2.48459489
10MP0008260_abnormal_autophagy2.38744358
11MP0004957_abnormal_blastocyst_morpholog2.35155161
12MP0009278_abnormal_bone_marrow2.11524347
13MP0003566_abnormal_cell_adhesion2.09539001
14MP0003303_peritoneal_inflammation2.08315512
15MP0008057_abnormal_DNA_replication2.07588400
16MP0001730_embryonic_growth_arrest2.02524757
17MP0002396_abnormal_hematopoietic_system1.92011180
18MP0003436_decreased_susceptibility_to1.88460592
19MP0004808_abnormal_hematopoietic_stem1.86648303
20MP0000350_abnormal_cell_proliferation1.79331021
21MP0008007_abnormal_cellular_replicative1.75534015
22MP0003300_gastrointestinal_ulcer1.74834618
23MP0004233_abnormal_muscle_weight1.64050986
24MP0005023_abnormal_wound_healing1.63140578
25MP0003191_abnormal_cellular_cholesterol1.59715484
26MP0005380_embryogenesis_phenotype1.57031916
27MP0001672_abnormal_embryogenesis/_devel1.57031916
28MP0001348_abnormal_lacrimal_gland1.55660572
29MP0004197_abnormal_fetal_growth/weight/1.55486822
30MP0003984_embryonic_growth_retardation1.54690945
31MP0002088_abnormal_embryonic_growth/wei1.52930856
32MP0005397_hematopoietic_system_phenotyp1.51140104
33MP0001545_abnormal_hematopoietic_system1.51140104
34MP0000490_abnormal_crypts_of1.47033381
35MP0002086_abnormal_extraembryonic_tissu1.45417704
36MP0005409_darkened_coat_color1.44464802
37MP0001697_abnormal_embryo_size1.40377380
38MP0001849_ear_inflammation1.38183740
39MP0000733_abnormal_muscle_development1.37939850
40MP0002398_abnormal_bone_marrow1.37637432
41MP0001800_abnormal_humoral_immune1.37514817
42MP0000685_abnormal_immune_system1.36105686
43MP0005666_abnormal_adipose_tissue1.35287718
44MP0002084_abnormal_developmental_patter1.32397939
45MP0001835_abnormal_antigen_presentation1.32071485
46MP0008438_abnormal_cutaneous_collagen1.31594506
47MP0002080_prenatal_lethality1.30698842
48MP0000003_abnormal_adipose_tissue1.28392831
49MP0002019_abnormal_tumor_incidence1.28227991
50MP0000858_altered_metastatic_potential1.27373919
51MP0002085_abnormal_embryonic_tissue1.25425458
52MP0000703_abnormal_thymus_morphology1.25423979
53MP0003448_altered_tumor_morphology1.25364966
54MP0002452_abnormal_antigen_presenting1.25007339
55MP0009840_abnormal_foam_cell1.24829596
56MP0005375_adipose_tissue_phenotype1.24466240
57MP0002722_abnormal_immune_system1.23656294
58MP0001915_intracranial_hemorrhage1.23091842
59MP0008058_abnormal_DNA_repair1.22738949
60MP0000689_abnormal_spleen_morphology1.20751704
61MP0004947_skin_inflammation1.20475684
62MP0009333_abnormal_splenocyte_physiolog1.20434473
63MP0003123_paternal_imprinting1.18906526
64MP0003763_abnormal_thymus_physiology1.17808574
65MP0009053_abnormal_anal_canal1.17795965
66MP0004858_abnormal_nervous_system1.16175471
67MP0002796_impaired_skin_barrier1.15657255
68MP0002009_preneoplasia1.15595810
69MP0003091_abnormal_cell_migration1.15141608
70MP0002877_abnormal_melanocyte_morpholog1.13441322
71MP0002998_abnormal_bone_remodeling1.12323688
72MP0002089_abnormal_postnatal_growth/wei1.10338740
73MP0002405_respiratory_system_inflammati1.09886853
74MP0003828_pulmonary_edema1.09282567
75MP0002060_abnormal_skin_morphology1.08939219
76MP0003656_abnormal_erythrocyte_physiolo1.08168159
77MP0000313_abnormal_cell_death1.08149623
78MP0003221_abnormal_cardiomyocyte_apopto1.08093870
79MP0002420_abnormal_adaptive_immunity1.08062187
80MP0001819_abnormal_immune_cell1.07241845
81MP0005501_abnormal_skin_physiology1.05748103
82MP0002429_abnormal_blood_cell1.05497404
83MP0000716_abnormal_immune_system1.04861313
84MP0001790_abnormal_immune_system1.04585914
85MP0005387_immune_system_phenotype1.04585914
86MP0008932_abnormal_embryonic_tissue1.04016209
87MP0004185_abnormal_adipocyte_glucose1.03042379
88MP0005000_abnormal_immune_tolerance1.02890464
89MP0010234_abnormal_vibrissa_follicle1.02802037
90MP0002723_abnormal_immune_serum1.01496291
91MP0010155_abnormal_intestine_physiology1.01117411
92MP0005464_abnormal_platelet_physiology1.00796693
93MP0006054_spinal_hemorrhage0.99362240
94MP0000678_abnormal_parathyroid_gland0.98972100
95MP0000747_muscle_weakness0.96277610
96MP0005257_abnormal_intraocular_pressure0.96202707
97MP0009672_abnormal_birth_weight0.95364359
98MP0000569_abnormal_digit_pigmentation0.94371634
99MP0005623_abnormal_meninges_morphology0.94349794
100MP0002419_abnormal_innate_immunity0.93466799
101MP0005621_abnormal_cell_physiology0.93332222
102MP0005025_abnormal_response_to0.92129902
103MP0001216_abnormal_epidermal_layer0.90978217
104MP0003567_abnormal_fetal_cardiomyocyte0.90739023
105MP0002166_altered_tumor_susceptibility0.90556497
106MP0002925_abnormal_cardiovascular_devel0.90334077
107MP0004087_abnormal_muscle_fiber0.89670979
108MP0001533_abnormal_skeleton_physiology0.88632689
109MP0005058_abnormal_lysosome_morphology0.87329592
110MP0001873_stomach_inflammation0.85507294
111MP0000759_abnormal_skeletal_muscle0.85062789
112MP0003329_amyloid_beta_deposits0.84509464
113MP0000428_abnormal_craniofacial_morphol0.84300599
114MP0008877_abnormal_DNA_methylation0.84083420
115MP0003172_abnormal_lysosome_physiology0.83347933
116MP0004510_myositis0.83169027
117MP0004264_abnormal_extraembryonic_tissu0.82594721
118MP0009931_abnormal_skin_appearance0.82287209
119MP0001851_eye_inflammation0.81135054
120MP0000767_abnormal_smooth_muscle0.80850817
121MP0008961_abnormal_basal_metabolism0.80311916
122MP0001853_heart_inflammation0.80159832
123MP0003453_abnormal_keratinocyte_physiol0.80085075
124MP0000371_diluted_coat_color0.79064721
125MP0005384_cellular_phenotype0.77810968
126MP0009785_altered_susceptibility_to0.76342201
127MP0002006_tumorigenesis0.75300903
128MP0000477_abnormal_intestine_morphology0.75150984
129MP0003115_abnormal_respiratory_system0.74478511
130MP0010630_abnormal_cardiac_muscle0.74253904
131MP0000465_gastrointestinal_hemorrhage0.73139001
132MP0001845_abnormal_inflammatory_respons0.72703052

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)3.01402570
2Selective tooth agenesis (HP:0001592)2.82589038
3Distal lower limb amyotrophy (HP:0008944)2.80322278
4Ependymoma (HP:0002888)2.75834054
5Increased density of long bones (HP:0006392)2.63855152
6Eczematoid dermatitis (HP:0000976)2.63207094
7Deep venous thrombosis (HP:0002625)2.57416435
8Short 4th metacarpal (HP:0010044)2.46238135
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46238135
10Hyperacusis (HP:0010780)2.42648516
11Ulnar bowing (HP:0003031)2.41675996
12Abnormality of the fingertips (HP:0001211)2.40307034
13High pitched voice (HP:0001620)2.38860058
14Deviation of the thumb (HP:0009603)2.38834781
15Broad face (HP:0000283)2.38714266
16Ankle contracture (HP:0006466)2.38597842
17Shallow orbits (HP:0000586)2.37587009
18Cellulitis (HP:0100658)2.35378436
19Centrally nucleated skeletal muscle fibers (HP:0003687)2.33982145
20Flat acetabular roof (HP:0003180)2.33661011
21Cutaneous melanoma (HP:0012056)2.33566514
22Protrusio acetabuli (HP:0003179)2.32835379
23Premature rupture of membranes (HP:0001788)2.29791884
24Vertebral compression fractures (HP:0002953)2.25889537
25Hemorrhage of the eye (HP:0011885)2.25877593
26Hand muscle atrophy (HP:0009130)2.25760928
27Achilles tendon contracture (HP:0001771)2.23364416
28Cervical subluxation (HP:0003308)2.17660492
29Proximal placement of thumb (HP:0009623)2.17390973
30Disproportionate tall stature (HP:0001519)2.16691788
31Asymmetry of the thorax (HP:0001555)2.14973672
32Metaphyseal cupping (HP:0003021)2.14113170
33Basal cell carcinoma (HP:0002671)2.11812711
34Recurrent viral infections (HP:0004429)2.11653884
35Upper limb amyotrophy (HP:0009129)2.11621229
36Distal upper limb amyotrophy (HP:0007149)2.11621229
37Ankyloglossia (HP:0010296)2.11310099
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.10618900
39Osteolytic defects of the hand bones (HP:0009699)2.10618900
40Abnormality of the Achilles tendon (HP:0005109)2.10178360
41Astrocytoma (HP:0009592)2.09920399
42Abnormality of the astrocytes (HP:0100707)2.09920399
43Insomnia (HP:0100785)2.08919386
44Autoimmune thrombocytopenia (HP:0001973)2.08685249
45Long palpebral fissure (HP:0000637)2.08329298
46Agnosia (HP:0010524)2.07421556
47Prominent nose (HP:0000448)2.06970302
48IgM deficiency (HP:0002850)2.06599516
49Dislocated radial head (HP:0003083)2.06000700
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04635229
51Persistence of primary teeth (HP:0006335)2.03888682
52Increased IgE level (HP:0003212)2.03604839
53Genu recurvatum (HP:0002816)2.02462167
54Bicuspid aortic valve (HP:0001647)2.00774945
55Colitis (HP:0002583)1.99764061
56Increased nuchal translucency (HP:0010880)1.99392728
57Reticulocytosis (HP:0001923)1.99199001
58Lower limb amyotrophy (HP:0007210)1.98169984
59Distal lower limb muscle weakness (HP:0009053)1.95816581
60Thin bony cortex (HP:0002753)1.95789118
61Abnormality of the peritoneum (HP:0002585)1.95016569
62Deep palmar crease (HP:0006191)1.94411058
63Degeneration of anterior horn cells (HP:0002398)1.93724110
64Abnormality of the anterior horn cell (HP:0006802)1.93724110
65Obstructive sleep apnea (HP:0002870)1.93700454
66Abnormality of oral frenula (HP:0000190)1.93525528
67Urethral obstruction (HP:0000796)1.93276790
68Recurrent abscess formation (HP:0002722)1.93153992
69Thrombocytosis (HP:0001894)1.91982566
70Long eyelashes (HP:0000527)1.90977085
71Abnormal platelet volume (HP:0011876)1.90462290
72Abnormality of the radial head (HP:0003995)1.88549976
73Biconcave vertebral bodies (HP:0004586)1.88482474
74Gastrointestinal carcinoma (HP:0002672)1.87190187
75Malignant gastrointestinal tract tumors (HP:0006749)1.87190187
76Abnormality of the calcaneus (HP:0008364)1.85171313
77Abnormality of the thoracic spine (HP:0100711)1.85058435
78Pustule (HP:0200039)1.84166908
79Radial bowing (HP:0002986)1.83919923
80Cerebral inclusion bodies (HP:0100314)1.83857595
81Increased mean platelet volume (HP:0011877)1.81986084
82Vertebral arch anomaly (HP:0008438)1.81527159
83Segmental peripheral demyelination/remyelination (HP:0003481)1.80884339
84Mitral valve prolapse (HP:0001634)1.79750591
85Subacute progressive viral hepatitis (HP:0006572)1.79469853
86Spinal muscular atrophy (HP:0007269)1.78691144
87Hematochezia (HP:0002573)1.78146670
88Syringomyelia (HP:0003396)1.77421624
89Spinal cord lesions (HP:0100561)1.77421624
90Dysmetric saccades (HP:0000641)1.77121885
91Abnormality of the 4th metacarpal (HP:0010012)1.77031854
92Abnormal number of incisors (HP:0011064)1.76883149
93Abnormal gallbladder physiology (HP:0012438)1.76397847
94Cholecystitis (HP:0001082)1.76397847
95Dilatation of the ascending aorta (HP:0005111)1.76063549
96Pseudobulbar signs (HP:0002200)1.75688944
97Myocardial infarction (HP:0001658)1.75398596
98Difficulty climbing stairs (HP:0003551)1.75012123
99Upper motor neuron abnormality (HP:0002127)1.73998592
100Missing ribs (HP:0000921)1.73548184
101Mediastinal lymphadenopathy (HP:0100721)1.73199556
102Progressive external ophthalmoplegia (HP:0000590)1.72826942
103Spastic diplegia (HP:0001264)1.71897218
104Recurrent fungal infections (HP:0002841)1.71417756
105Mitral regurgitation (HP:0001653)1.71064779
106Recurrent bacterial skin infections (HP:0005406)1.70486360
107Aneurysm (HP:0002617)1.70125690
108Fatigue (HP:0012378)1.69504387
109Abnormality of skeletal muscle fiber size (HP:0012084)1.69244042
110Amaurosis fugax (HP:0100576)1.68897572
111Heterotopia (HP:0002282)1.68143213
112Medulloblastoma (HP:0002885)1.67948507
113Increased variability in muscle fiber diameter (HP:0003557)1.67276385
114Squamous cell carcinoma (HP:0002860)1.65706335
115Pointed chin (HP:0000307)1.65604557
116Skin tags (HP:0010609)1.63685608
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63420972
118Fragile skin (HP:0001030)1.63185259
119Absent frontal sinuses (HP:0002688)1.62862835
120Sandal gap (HP:0001852)1.62841211
121Increased connective tissue (HP:0009025)1.62677254
122Wormian bones (HP:0002645)1.62422899
123Slow saccadic eye movements (HP:0000514)1.62000903
124Renal duplication (HP:0000075)1.60950420
125Gastrointestinal inflammation (HP:0004386)1.60855239
126Broad palm (HP:0001169)1.60735717
127Biliary tract neoplasm (HP:0100574)1.60104640
128Broad thumb (HP:0011304)1.59852932
129Back pain (HP:0003418)1.59232999
130Patellar dislocation (HP:0002999)1.58975570
131Thoracic kyphosis (HP:0002942)1.58679259
132Severe short stature (HP:0003510)1.58638937
133Renovascular hypertension (HP:0100817)1.58159844
134Polycythemia (HP:0001901)1.57839871
135Progressive muscle weakness (HP:0003323)1.56849283
136Wrist flexion contracture (HP:0001239)1.56724518
137Cafe-au-lait spot (HP:0000957)1.55905639
138Aortic aneurysm (HP:0004942)1.55449730
139Interstitial pulmonary disease (HP:0006530)1.55398787
140Onion bulb formation (HP:0003383)1.55097393
141Decreased motor nerve conduction velocity (HP:0003431)1.54687381
142Abnormality of macrophages (HP:0004311)1.54364832
143Rhabdomyosarcoma (HP:0002859)1.54180331
144Dysostosis multiplex (HP:0000943)1.53887486
145Bowed forearm bones (HP:0003956)1.53745785
146Bowing of the arm (HP:0006488)1.53745785
147Nasal polyposis (HP:0100582)1.53197849
148Reticulocytopenia (HP:0001896)1.52311777
149Glioma (HP:0009733)1.51992889
150J-shaped sella turcica (HP:0002680)1.51855027
151Micronodular cirrhosis (HP:0001413)1.51288853
152Gingivitis (HP:0000230)1.51142471
153Advanced eruption of teeth (HP:0006288)1.51005100
154Viral hepatitis (HP:0006562)1.50493884
155Cutis marmorata (HP:0000965)1.50194017
156Short humerus (HP:0005792)1.49839241
157Neuronal loss in central nervous system (HP:0002529)1.49793545
158Adenoma sebaceum (HP:0009720)1.49493569
159Angiofibromas (HP:0010615)1.49493569
160Colon cancer (HP:0003003)1.49422651
161Peritonitis (HP:0002586)1.49285767
162Neoplasm of the oral cavity (HP:0100649)1.49213538
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.49038163
164Ragged-red muscle fibers (HP:0003200)1.48619622
165Insidious onset (HP:0003587)1.48245999
166Termporal pattern (HP:0011008)1.48245999
167Peripheral hypomyelination (HP:0007182)1.47826560
168Spinal rigidity (HP:0003306)1.47652730
169Blue sclerae (HP:0000592)1.47313692
170Abnormal ossification of hand bones (HP:0005921)1.46682946
171Bowel incontinence (HP:0002607)1.46603150
172Polygenic inheritance (HP:0010982)1.45725665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.89445096
2CDK123.62526007
3PRPF4B3.31974816
4SMG13.10835335
5TRIB33.09271490
6CDC73.01003337
7MAP3K103.00649851
8PKN22.94613798
9NEK22.52741245
10IRAK32.32964060
11MAP4K12.27991059
12STK102.27463130
13TTN1.86920419
14ERN11.77261734
15TESK21.71511642
16MAP3K131.53224919
17RPS6KB21.52294243
18LRRK21.50433862
19TTK1.47624027
20CDK41.44168776
21PTK61.41289463
22PAK41.40968282
23MAP2K31.37269104
24EPHA21.36690711
25ALK1.34688304
26KSR21.31040908
27MAP3K81.30903088
28RPS6KA41.28570198
29GRK61.25972955
30RIPK11.24032686
31TSSK61.23397239
32PASK1.22485018
33BMX1.20587397
34CDK61.19359444
35TYK21.19142453
36RIPK41.17951043
37MTOR1.15468026
38SCYL21.14811295
39WEE11.12601525
40TGFBR11.12273629
41PIM11.11276198
42ATR1.10145945
43IRAK41.09408744
44CDK71.06785388
45NEK11.05044707
46CLK11.03218797
47BRD41.00780052
48CDC42BPA1.00304638
49ICK0.97746198
50STK30.96977022
51MARK20.96338013
52TESK10.95996142
53PDGFRA0.94935266
54JAK30.93764595
55BTK0.93160787
56ZAP700.92107956
57STK40.92036354
58CHEK10.90986027
59TAOK20.90818085
60LATS20.90476751
61CAMK1D0.90408040
62MAP3K10.88723751
63MST1R0.88569771
64SIK10.87943537
65FLT30.87885558
66CHUK0.87859635
67CSF1R0.87128170
68AURKB0.86074797
69FGFR40.86032769
70TBK10.85847309
71BUB10.83395353
72PLK10.83074495
73SIK30.82755207
74PDPK10.82091751
75IRAK20.80778911
76ACVR1B0.74380485
77RET0.73533079
78PAK20.73415888
79HCK0.70266353
80MELK0.69198612
81PRKD20.67949536
82MARK30.66933573
83* CDK20.66885809
84SIK20.66819557
85EPHB10.65276576
86NEK90.65247781
87TAOK10.65006065
88DDR20.64846173
89MAP3K30.64008832
90ITK0.62271594
91MAP2K20.60929353
92RPS6KA20.59810135
93CSK0.59445207
94ATM0.59367996
95LATS10.58929400
96FGFR30.56580814
97HIPK20.56303026
98NME20.56228582
99MAP3K70.56025415
100FGR0.55762942
101PDGFRB0.55154174
102NTRK10.54732547
103JAK10.54674204
104IKBKB0.54593183
105TRPM70.54533719
106DMPK0.52355917
107PDK10.51432022
108SGK30.50430935
109RPS6KA10.49369899
110BLK0.49117796
111MAPKAPK30.48368478
112CAMK1G0.48292774
113ILK0.48044555
114MET0.47860580
115IRAK10.47551038
116FGFR10.47408256
117CHEK20.46936150
118PTK20.46401307
119RPS6KC10.45522304
120RPS6KL10.45522304
121RPS6KA60.45443219
122PRKD30.44479521
123MAP3K110.44159239
124CDK90.44049854
125TYRO30.43163808
126MOS0.43036424
127LCK0.42716293
128MAPK110.42662576
129MAPK120.42259284
130TGFBR20.41778767
131MAP3K140.41723125
132MAP3K60.41700500
133DYRK1B0.41469770
134EPHA30.40555217
135EGFR0.38563908
136CAMKK10.37622785
137JAK20.37025257
138MAPK100.35959124
139TLK10.35811554
140MAPKAPK20.35595538

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.89427525
2One carbon pool by folate_Homo sapiens_hsa006702.36528621
3Other glycan degradation_Homo sapiens_hsa005112.34443292
4RNA transport_Homo sapiens_hsa030132.12103704
5Mismatch repair_Homo sapiens_hsa034302.10389568
6Cell cycle_Homo sapiens_hsa041102.00779165
7* Spliceosome_Homo sapiens_hsa030401.91549040
8Base excision repair_Homo sapiens_hsa034101.91426057
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91329655
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74066264
11Chronic myeloid leukemia_Homo sapiens_hsa052201.72404277
12Antigen processing and presentation_Homo sapiens_hsa046121.57155329
13Leishmaniasis_Homo sapiens_hsa051401.55614949
14Small cell lung cancer_Homo sapiens_hsa052221.51084656
15mRNA surveillance pathway_Homo sapiens_hsa030151.49679044
16Viral carcinogenesis_Homo sapiens_hsa052031.49527921
17B cell receptor signaling pathway_Homo sapiens_hsa046621.47272229
18MicroRNAs in cancer_Homo sapiens_hsa052061.38090381
19Legionellosis_Homo sapiens_hsa051341.36907956
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36061927
21p53 signaling pathway_Homo sapiens_hsa041151.35845137
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.35060749
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.30592345
24Herpes simplex infection_Homo sapiens_hsa051681.29968272
25Prion diseases_Homo sapiens_hsa050201.28279227
26Apoptosis_Homo sapiens_hsa042101.27637478
27Osteoclast differentiation_Homo sapiens_hsa043801.27193870
28HTLV-I infection_Homo sapiens_hsa051661.27004843
29Acute myeloid leukemia_Homo sapiens_hsa052211.21208675
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20007338
31Notch signaling pathway_Homo sapiens_hsa043301.17021413
32mTOR signaling pathway_Homo sapiens_hsa041501.16946038
33Epstein-Barr virus infection_Homo sapiens_hsa051691.16355628
34ErbB signaling pathway_Homo sapiens_hsa040121.15949082
35Toxoplasmosis_Homo sapiens_hsa051451.15782320
36Nucleotide excision repair_Homo sapiens_hsa034201.14820946
37Measles_Homo sapiens_hsa051621.14449623
38Prolactin signaling pathway_Homo sapiens_hsa049171.12144051
39Viral myocarditis_Homo sapiens_hsa054161.11767821
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.10370044
41Systemic lupus erythematosus_Homo sapiens_hsa053221.10231500
42Insulin signaling pathway_Homo sapiens_hsa049101.09936455
43Hepatitis B_Homo sapiens_hsa051611.09230526
44Fructose and mannose metabolism_Homo sapiens_hsa000511.08511986
45Adherens junction_Homo sapiens_hsa045201.07741769
46Proteoglycans in cancer_Homo sapiens_hsa052051.07520390
47Hepatitis C_Homo sapiens_hsa051601.06387544
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.06108391
49Lysine degradation_Homo sapiens_hsa003101.05397817
50HIF-1 signaling pathway_Homo sapiens_hsa040661.05393402
51Homologous recombination_Homo sapiens_hsa034401.05363815
52Colorectal cancer_Homo sapiens_hsa052101.03786874
53Non-small cell lung cancer_Homo sapiens_hsa052231.03779677
54Primary immunodeficiency_Homo sapiens_hsa053401.02489282
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00979951
56Non-homologous end-joining_Homo sapiens_hsa034500.99509246
57Pancreatic cancer_Homo sapiens_hsa052120.98855720
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96663590
59Shigellosis_Homo sapiens_hsa051310.95222093
60Staphylococcus aureus infection_Homo sapiens_hsa051500.94834573
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94508385
62Bladder cancer_Homo sapiens_hsa052190.92980244
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92854545
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92548696
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92461717
66Influenza A_Homo sapiens_hsa051640.91764851
67RNA degradation_Homo sapiens_hsa030180.90661107
68Choline metabolism in cancer_Homo sapiens_hsa052310.90103164
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.89534114
70Selenocompound metabolism_Homo sapiens_hsa004500.88620200
71Inositol phosphate metabolism_Homo sapiens_hsa005620.88562886
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88286169
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87669249
74T cell receptor signaling pathway_Homo sapiens_hsa046600.87347991
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.87293363
76Pentose phosphate pathway_Homo sapiens_hsa000300.87220783
77GnRH signaling pathway_Homo sapiens_hsa049120.86162065
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.86141341
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84697367
80Galactose metabolism_Homo sapiens_hsa000520.84405216
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83703830
82Estrogen signaling pathway_Homo sapiens_hsa049150.82419902
83Focal adhesion_Homo sapiens_hsa045100.81149061
84TNF signaling pathway_Homo sapiens_hsa046680.80381350
85Biosynthesis of amino acids_Homo sapiens_hsa012300.80299366
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79562052
87VEGF signaling pathway_Homo sapiens_hsa043700.75056278
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74474754
89Thyroid cancer_Homo sapiens_hsa052160.74390749
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.72500670
91AMPK signaling pathway_Homo sapiens_hsa041520.71842559
92Endometrial cancer_Homo sapiens_hsa052130.71829798
93Endocytosis_Homo sapiens_hsa041440.71522938
94TGF-beta signaling pathway_Homo sapiens_hsa043500.71445924
95Hippo signaling pathway_Homo sapiens_hsa043900.70852696
96Tuberculosis_Homo sapiens_hsa051520.70507701
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70440026
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68787059
99Prostate cancer_Homo sapiens_hsa052150.67957606
100Amoebiasis_Homo sapiens_hsa051460.67852495
101Fanconi anemia pathway_Homo sapiens_hsa034600.67736680
102Insulin resistance_Homo sapiens_hsa049310.67700564
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.67342749
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67006192
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66680193
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66241836
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65721747
108Platelet activation_Homo sapiens_hsa046110.65238472
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64504033
110Hematopoietic cell lineage_Homo sapiens_hsa046400.63425384
111Pathways in cancer_Homo sapiens_hsa052000.62229802
112Lysosome_Homo sapiens_hsa041420.61476584
113Glioma_Homo sapiens_hsa052140.60455235
114Pyrimidine metabolism_Homo sapiens_hsa002400.60359181
115Pertussis_Homo sapiens_hsa051330.60217143
116Salmonella infection_Homo sapiens_hsa051320.59752395
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.59216850
118Type II diabetes mellitus_Homo sapiens_hsa049300.57475764
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55947716
120Malaria_Homo sapiens_hsa051440.55141192
121Ribosome_Homo sapiens_hsa030100.54139369
122Renal cell carcinoma_Homo sapiens_hsa052110.53849101
123FoxO signaling pathway_Homo sapiens_hsa040680.53104012
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52629611
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51532883
126Chemokine signaling pathway_Homo sapiens_hsa040620.51524003
127Long-term potentiation_Homo sapiens_hsa047200.51286885
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51039524

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »