DHRSX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)4.20667874
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18871936
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17024203
4ATP synthesis coupled proton transport (GO:0015986)4.17024203
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12293895
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12293895
7mannosylation (GO:0097502)4.09850248
8L-phenylalanine metabolic process (GO:0006558)3.98331820
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98331820
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95308355
11chaperone-mediated protein transport (GO:0072321)3.88426970
12behavioral response to nicotine (GO:0035095)3.85598470
13platelet dense granule organization (GO:0060155)3.81826440
14positive regulation of prostaglandin secretion (GO:0032308)3.73080645
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.71843516
16NADH dehydrogenase complex assembly (GO:0010257)3.71843516
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71843516
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71781721
19L-phenylalanine catabolic process (GO:0006559)3.71781721
20protein complex biogenesis (GO:0070271)3.69015054
21sequestering of actin monomers (GO:0042989)3.68072773
22negative regulation of cholesterol transport (GO:0032375)3.65648269
23negative regulation of sterol transport (GO:0032372)3.65648269
24alpha-linolenic acid metabolic process (GO:0036109)3.60918943
25antigen processing and presentation of endogenous antigen (GO:0019883)3.60832084
26ubiquinone biosynthetic process (GO:0006744)3.58521685
27kynurenine metabolic process (GO:0070189)3.50952107
28glycine metabolic process (GO:0006544)3.44372942
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44221343
30cysteine metabolic process (GO:0006534)3.43450876
31regulation of cholesterol homeostasis (GO:2000188)3.43241167
32aromatic amino acid family catabolic process (GO:0009074)3.42110363
33sulfur amino acid catabolic process (GO:0000098)3.40682906
34glyoxylate metabolic process (GO:0046487)3.40252004
35pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39877532
36negative regulation of telomere maintenance (GO:0032205)3.37076210
37urea cycle (GO:0000050)3.35527619
38urea metabolic process (GO:0019627)3.35527619
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34797808
40protein neddylation (GO:0045116)3.34650752
41peptidyl-glutamic acid carboxylation (GO:0017187)3.33737512
42protein carboxylation (GO:0018214)3.33737512
43ubiquinone metabolic process (GO:0006743)3.32812705
44mitochondrial respiratory chain complex assembly (GO:0033108)3.30896068
45epithelial cilium movement (GO:0003351)3.30762206
46pyrimidine nucleobase catabolic process (GO:0006208)3.30507037
47electron transport chain (GO:0022900)3.26321769
48negative regulation of fibrinolysis (GO:0051918)3.24936650
49respiratory electron transport chain (GO:0022904)3.24397634
50water-soluble vitamin biosynthetic process (GO:0042364)3.24104814
51plasma lipoprotein particle clearance (GO:0034381)3.22215889
52tryptophan catabolic process (GO:0006569)3.18176833
53indole-containing compound catabolic process (GO:0042436)3.18176833
54indolalkylamine catabolic process (GO:0046218)3.18176833
55amine catabolic process (GO:0009310)3.16531118
56cellular biogenic amine catabolic process (GO:0042402)3.16531118
57regulation of triglyceride catabolic process (GO:0010896)3.13972001
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13710321
59high-density lipoprotein particle remodeling (GO:0034375)3.12817144
60pentose-phosphate shunt (GO:0006098)3.09370745
61lysine catabolic process (GO:0006554)3.08967789
62lysine metabolic process (GO:0006553)3.08967789
63serine family amino acid biosynthetic process (GO:0009070)3.08959994
64protein-cofactor linkage (GO:0018065)3.05905372
65plasma lipoprotein particle assembly (GO:0034377)3.05584936
66nitrogen cycle metabolic process (GO:0071941)3.05360401
67phospholipid efflux (GO:0033700)3.00508582
68positive regulation of triglyceride metabolic process (GO:0090208)2.98370415
69regulation of prostaglandin secretion (GO:0032306)2.97970930
70positive regulation of lymphocyte apoptotic process (GO:0070230)2.95989106
71low-density lipoprotein particle clearance (GO:0034383)2.94676093
72tryptophan metabolic process (GO:0006568)2.94545728
73positive regulation of triglyceride lipase activity (GO:0061365)2.94435562
74positive regulation of lipoprotein lipase activity (GO:0051006)2.94435562
75positive regulation of T cell apoptotic process (GO:0070234)2.93733262
76serine family amino acid metabolic process (GO:0009069)2.91588902
77serine family amino acid catabolic process (GO:0009071)2.91268458
78pyrimidine nucleotide catabolic process (GO:0006244)2.89131987
79protein-lipid complex assembly (GO:0065005)2.88702179
80positive regulation of icosanoid secretion (GO:0032305)2.88512215
81proteasome assembly (GO:0043248)2.88041801
82negative regulation of interleukin-1 beta production (GO:0032691)2.87579906
83respiratory chain complex IV assembly (GO:0008535)2.86289364
84quinone biosynthetic process (GO:1901663)2.85936837
85proline biosynthetic process (GO:0006561)2.85557507
86positive regulation of triglyceride biosynthetic process (GO:0010867)2.84144582
87regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82834756
88complement activation, alternative pathway (GO:0006957)2.82632495
89iron-sulfur cluster assembly (GO:0016226)2.82479650
90metallo-sulfur cluster assembly (GO:0031163)2.82479650
91positive regulation of histone deacetylation (GO:0031065)2.82004292
92bile acid biosynthetic process (GO:0006699)2.82002871
93hydrogen ion transmembrane transport (GO:1902600)2.81371344
94cytochrome complex assembly (GO:0017004)2.80383712
95maternal placenta development (GO:0001893)2.80020354
96positive regulation of fatty acid transport (GO:2000193)2.79789340
97ethanol oxidation (GO:0006069)2.79269911
98viral transcription (GO:0019083)2.78833617
99intestinal cholesterol absorption (GO:0030299)2.77094173
100indolalkylamine metabolic process (GO:0006586)2.76115634
101negative regulation of interleukin-1 production (GO:0032692)2.75347105
102regulation of fibrinolysis (GO:0051917)2.75246886
103intracellular protein transmembrane import (GO:0044743)2.73455175
104homocysteine metabolic process (GO:0050667)2.73000985
105positive regulation of gamma-delta T cell activation (GO:0046645)2.72311051
106proton transport (GO:0015992)2.71520576
107reverse cholesterol transport (GO:0043691)2.69861458
108regulation of gamma-delta T cell differentiation (GO:0045586)2.69140698
109NADPH regeneration (GO:0006740)2.69119237
110regulation of cholesterol storage (GO:0010885)2.68913833
111amino-acid betaine metabolic process (GO:0006577)2.68340682
112regulation of cholesterol esterification (GO:0010872)2.67923898
113vitamin biosynthetic process (GO:0009110)2.67349505
114deoxyribonucleotide catabolic process (GO:0009264)2.67106749
115regulation of chronic inflammatory response (GO:0002676)2.66111390
1164-hydroxyproline metabolic process (GO:0019471)2.65795765
117hydrogen transport (GO:0006818)2.65475635
118regulation of protein activation cascade (GO:2000257)2.65072907
119somite development (GO:0061053)2.64575378
120preassembly of GPI anchor in ER membrane (GO:0016254)2.64138077
121DNA deamination (GO:0045006)2.62706823
122positive regulation of organic acid transport (GO:0032892)2.62687895
123plasma lipoprotein particle remodeling (GO:0034369)2.62619173
124protein-lipid complex remodeling (GO:0034368)2.62619173
125macromolecular complex remodeling (GO:0034367)2.62619173
126positive thymic T cell selection (GO:0045059)2.62081136
127DNA damage response, detection of DNA damage (GO:0042769)2.61155186
128proline metabolic process (GO:0006560)2.60656342
129L-serine metabolic process (GO:0006563)2.60172111
130base-excision repair, AP site formation (GO:0006285)2.60164174
131regulation of superoxide anion generation (GO:0032928)2.59212735
132translational termination (GO:0006415)2.58575580
133folic acid-containing compound biosynthetic process (GO:0009396)2.58313197
134cholesterol homeostasis (GO:0042632)2.56600788
135regulation of immunoglobulin secretion (GO:0051023)2.54072026
136regulation of fatty acid beta-oxidation (GO:0031998)2.53822236
137nucleobase catabolic process (GO:0046113)2.53678614
138regulation of mononuclear cell migration (GO:0071675)2.53504944
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.52707730
140cellular modified amino acid catabolic process (GO:0042219)2.52546404
141very-low-density lipoprotein particle assembly (GO:0034379)2.52014680
142bile acid metabolic process (GO:0008206)2.51408438
143quinone metabolic process (GO:1901661)2.50934033
144cellular response to interferon-beta (GO:0035458)2.50919373
145sterol homeostasis (GO:0055092)2.50825920
146triglyceride homeostasis (GO:0070328)2.49451257
147acylglycerol homeostasis (GO:0055090)2.49451257
148ethanol metabolic process (GO:0006067)2.48583731
149regulation of complement activation (GO:0030449)2.47864358
150regulation of gamma-delta T cell activation (GO:0046643)2.47749256
151response to laminar fluid shear stress (GO:0034616)2.47610026
152regulation of triglyceride metabolic process (GO:0090207)2.47386508
153arginine catabolic process (GO:0006527)2.46185725
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45820709
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45820709
156primary alcohol catabolic process (GO:0034310)2.45203437
157positive regulation of calcium ion import (GO:0090280)2.44459416
158aromatic amino acid family metabolic process (GO:0009072)2.44456364
159GTP biosynthetic process (GO:0006183)2.43967799
160positive regulation of lipid catabolic process (GO:0050996)2.43618827
161cholesterol efflux (GO:0033344)2.43038247
162piRNA metabolic process (GO:0034587)2.41554130
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.41363154
164purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41275808
165translational elongation (GO:0006414)2.40710671
166purine nucleoside triphosphate biosynthetic process (GO:0009145)2.40654203
167ATP biosynthetic process (GO:0006754)2.40425706
168fucose catabolic process (GO:0019317)2.40245232
169L-fucose metabolic process (GO:0042354)2.40245232
170L-fucose catabolic process (GO:0042355)2.40245232
171aldehyde catabolic process (GO:0046185)2.38893149
172valine metabolic process (GO:0006573)2.38276384
173transcription elongation from RNA polymerase III promoter (GO:0006385)2.38012511
174termination of RNA polymerase III transcription (GO:0006386)2.38012511
175positive regulation of amino acid transport (GO:0051957)2.37985809
176negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37702772
177one-carbon metabolic process (GO:0006730)2.37357973
178deoxyribose phosphate catabolic process (GO:0046386)2.37265224
179negative regulation of fatty acid biosynthetic process (GO:0045717)2.37196349
180alpha-amino acid catabolic process (GO:1901606)2.36371729
181cilium movement (GO:0003341)2.36283835
182protein polyglutamylation (GO:0018095)2.36100516
183negative regulation of lipid transport (GO:0032369)2.35411873
184plasma lipoprotein particle organization (GO:0071827)2.35324429
185mitochondrial calcium ion transport (GO:0006851)2.32442066
186intraciliary transport (GO:0042073)2.30235726
187negative regulation of mast cell activation (GO:0033004)2.29749692
188anterograde synaptic vesicle transport (GO:0048490)2.27527774
189pyrimidine-containing compound catabolic process (GO:0072529)2.27149835
190positive regulation of defense response to virus by host (GO:0002230)2.25937647
191C-terminal protein lipidation (GO:0006501)2.24159908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48339010
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.45914482
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.99794929
4ZNF274_21170338_ChIP-Seq_K562_Hela3.67053697
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.56237135
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.37133708
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17170492
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.15523605
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.11674026
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78428670
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.73248709
12MYC_22102868_ChIP-Seq_BL_Human2.69700952
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60613702
14VDR_21846776_ChIP-Seq_THP-1_Human2.53333821
15E2F7_22180533_ChIP-Seq_HELA_Human2.48569272
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.47865318
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.21400893
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17401740
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.14648688
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.09490523
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06050245
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.01374081
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.99915092
24VDR_22108803_ChIP-Seq_LS180_Human1.96596585
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91011193
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82312305
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.81762661
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.80100995
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75575885
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75358842
31VDR_23849224_ChIP-Seq_CD4+_Human1.72643980
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72510053
33TCF7_22412390_ChIP-Seq_EML_Mouse1.72433586
34MAF_26560356_Chip-Seq_TH1_Human1.72072845
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69530604
36LXR_22292898_ChIP-Seq_THP-1_Human1.69325008
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.69195185
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.68263883
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64163229
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.63671086
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60398444
42IGF1R_20145208_ChIP-Seq_DFB_Human1.59179069
43UTX_26944678_Chip-Seq_JUKART_Human1.59021238
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58839442
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57122711
46TP53_22573176_ChIP-Seq_HFKS_Human1.55756972
47VDR_24763502_ChIP-Seq_THP-1_Human1.52528659
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50499075
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50378290
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49888826
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47867843
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47607989
53IRF1_19129219_ChIP-ChIP_H3396_Human1.46735227
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45346331
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45172055
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44763592
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44710773
58SCL_19346495_ChIP-Seq_HPC-7_Human1.44194749
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43676422
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.43647157
61MYC_18940864_ChIP-ChIP_HL60_Human1.43561980
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43442891
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42534971
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41637651
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41361615
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41010572
67KDM2B_26808549_Chip-Seq_DND41_Human1.40982360
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.37194463
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36580684
70P300_19829295_ChIP-Seq_ESCs_Human1.36452045
71MAF_26560356_Chip-Seq_TH2_Human1.35879446
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.35821887
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33938685
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33041291
75ZNF263_19887448_ChIP-Seq_K562_Human1.32936224
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32445610
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31948646
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.31096206
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.30328087
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30301614
81GABP_19822575_ChIP-Seq_HepG2_Human1.30252802
82RACK7_27058665_Chip-Seq_MCF-7_Human1.29768595
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28336528
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28250204
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27842827
86ELK1_19687146_ChIP-ChIP_HELA_Human1.26369238
87MYB_26560356_Chip-Seq_TH1_Human1.25961990
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25817012
89AR_20517297_ChIP-Seq_VCAP_Human1.25434821
90NANOG_19829295_ChIP-Seq_ESCs_Human1.23990621
91SOX2_19829295_ChIP-Seq_ESCs_Human1.23990621
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23183123
93FOXP3_21729870_ChIP-Seq_TREG_Human1.23130639
94CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22575626
95* GBX2_23144817_ChIP-Seq_PC3_Human1.22417024
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22151802
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21548891
98NANOG_20526341_ChIP-Seq_ESCs_Human1.20921303
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20899771
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20807567
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20332249
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18818535
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18797312
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18671657
105EWS_26573619_Chip-Seq_HEK293_Human1.18332024
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18070994
107MYB_26560356_Chip-Seq_TH2_Human1.18021495
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.17076022
109ERA_21632823_ChIP-Seq_H3396_Human1.17020519
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14740694
111FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14539728
112BCOR_27268052_Chip-Seq_Bcells_Human1.13784272
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13384958
114ATF3_27146783_Chip-Seq_COLON_Human1.11633209
115CBX2_27304074_Chip-Seq_ESCs_Mouse1.11492499
116FOXH1_21741376_ChIP-Seq_EPCs_Human1.11355699
117XRN2_22483619_ChIP-Seq_HELA_Human1.10299386
118IRF8_21731497_ChIP-ChIP_J774_Mouse1.10028068
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09596273
120SPI1_23547873_ChIP-Seq_NB4_Human1.09504185
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09454581
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.09454581
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09192379
124BCL6_27268052_Chip-Seq_Bcells_Human1.09061247
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.08645537
126MYC_19829295_ChIP-Seq_ESCs_Human1.08371833
127FLI1_27457419_Chip-Seq_LIVER_Mouse1.07544592
128TAF2_19829295_ChIP-Seq_ESCs_Human1.07488521
129P68_20966046_ChIP-Seq_HELA_Human1.07266722
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07250708
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.07186136
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07096739
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06776786
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06093999
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.05520067
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05268828
137RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04833295
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03838402
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03838402
140MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03665682
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03556312
142NCOR1_26117541_ChIP-Seq_K562_Human1.03232377
143CLOCK_20551151_ChIP-Seq_293T_Human1.02880409
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02235863
145TET1_21451524_ChIP-Seq_MESCs_Mouse1.00668657
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00067835
147CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99980953
148NCOR_22424771_ChIP-Seq_293T_Human0.98981267
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98864449
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98495191
151CTCF_21964334_Chip-Seq_Bcells_Human0.98064026
152SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97919236
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97523051
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.97338967
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97212457
156STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97158551
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96984068
158HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96738847
159CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96698663
160CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96645265
161SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96581236
162CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96524286
163BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96342570
164CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95728905
165E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95609055
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95479583
167CTCF_26484167_Chip-Seq_Bcells_Mouse0.94747396
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94104253
169UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93372454
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92554688
171HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92541079
172SOX2_16153702_ChIP-ChIP_HESCs_Human0.92306638
173THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91812101
174FOXH1_21741376_ChIP-Seq_ESCs_Human0.89097552
175SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89060082
176P53_21459846_ChIP-Seq_SAOS-2_Human0.89032233
177POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88647441
178FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88414054
179EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85890838
180E2F1_20622854_ChIP-Seq_HELA_Human0.85055954
181FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84514461
182BCAT_22108803_ChIP-Seq_LS180_Human0.83927345
183CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83797642
184ELK1_22589737_ChIP-Seq_MCF10A_Human0.83272995
185STAT1_20625510_ChIP-Seq_HELA_Human0.82764526
186CTCF_20526341_ChIP-Seq_ESCs_Human0.81518504
187RNF2_27304074_Chip-Seq_NSC_Mouse0.80823787

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.14930680
2MP0002139_abnormal_hepatobiliary_system4.05978616
3MP0009840_abnormal_foam_cell3.48882919
4MP0006292_abnormal_olfactory_placode3.27990578
5MP0005365_abnormal_bile_salt2.92399882
6MP0002653_abnormal_ependyma_morphology2.92126555
7MP0005085_abnormal_gallbladder_physiolo2.68462910
8MP0003136_yellow_coat_color2.64585798
9MP0003705_abnormal_hypodermis_morpholog2.64383134
10MP0005083_abnormal_biliary_tract2.45411227
11MP0003191_abnormal_cellular_cholesterol2.34029867
12MP0008875_abnormal_xenobiotic_pharmacok2.16089924
13MP0000685_abnormal_immune_system2.15838975
14MP0004133_heterotaxia2.10829255
15MP0003436_decreased_susceptibility_to2.10214134
16MP0004142_abnormal_muscle_tone2.04657326
17MP0003806_abnormal_nucleotide_metabolis2.04314998
18MP0009764_decreased_sensitivity_to1.96403396
19MP0002148_abnormal_hypersensitivity_rea1.92988260
20MP0003303_peritoneal_inflammation1.91819847
21MP0003300_gastrointestinal_ulcer1.83510606
22MP0010329_abnormal_lipoprotein_level1.83233169
23MP0000609_abnormal_liver_physiology1.76320954
24MP0009379_abnormal_foot_pigmentation1.69290692
25MP0003656_abnormal_erythrocyte_physiolo1.68011779
26MP0001529_abnormal_vocalization1.67597561
27MP0002277_abnormal_respiratory_mucosa1.66235833
28MP0004147_increased_porphyrin_level1.64145791
29MP0002102_abnormal_ear_morphology1.62869722
30MP0001666_abnormal_nutrient_absorption1.62611271
31MP0003252_abnormal_bile_duct1.62177714
32MP0002876_abnormal_thyroid_physiology1.60896980
33MP0003122_maternal_imprinting1.59645619
34MP0009278_abnormal_bone_marrow1.58568905
35MP0009333_abnormal_splenocyte_physiolog1.58014961
36MP0002163_abnormal_gland_morphology1.57378822
37MP0001800_abnormal_humoral_immune1.57262684
38MP0000569_abnormal_digit_pigmentation1.56558351
39MP0003121_genomic_imprinting1.56171927
40MP0006072_abnormal_retinal_apoptosis1.55484400
41MP0003787_abnormal_imprinting1.53025905
42MP0002938_white_spotting1.52284395
43MP0005451_abnormal_body_composition1.51119720
44MP0004947_skin_inflammation1.49650346
45MP0001835_abnormal_antigen_presentation1.49222410
46MP0008789_abnormal_olfactory_epithelium1.48155054
47MP0005387_immune_system_phenotype1.47769312
48MP0001790_abnormal_immune_system1.47769312
49MP0004742_abnormal_vestibular_system1.46999081
50MP0001542_abnormal_bone_strength1.46437468
51MP0005464_abnormal_platelet_physiology1.44044078
52MP0001293_anophthalmia1.41425322
53MP0005025_abnormal_response_to1.41158999
54MP0005332_abnormal_amino_acid1.40851440
55MP0003763_abnormal_thymus_physiology1.38901501
56MP0010352_gastrointestinal_tract_polyps1.38880165
57MP0005084_abnormal_gallbladder_morpholo1.38653293
58MP0005397_hematopoietic_system_phenotyp1.38164831
59MP0001545_abnormal_hematopoietic_system1.38164831
60MP0002166_altered_tumor_susceptibility1.34659058
61MP0008877_abnormal_DNA_methylation1.32976764
62MP0001919_abnormal_reproductive_system1.32957267
63MP0000372_irregular_coat_pigmentation1.32777229
64MP0002736_abnormal_nociception_after1.32097097
65MP0002452_abnormal_antigen_presenting1.30170668
66MP0002138_abnormal_hepatobiliary_system1.29701560
67MP0005379_endocrine/exocrine_gland_phen1.28557519
68MP0000343_altered_response_to1.26713568
69MP0002723_abnormal_immune_serum1.26585099
70MP0002837_dystrophic_cardiac_calcinosis1.26489232
71MP0005319_abnormal_enzyme/_coenzyme1.26082960
72MP0005253_abnormal_eye_physiology1.25634553
73MP0000689_abnormal_spleen_morphology1.25494588
74MP0003646_muscle_fatigue1.23894511
75MP0001324_abnormal_eye_pigmentation1.23438452
76MP0008469_abnormal_protein_level1.23287324
77MP0002405_respiratory_system_inflammati1.22779749
78MP0002398_abnormal_bone_marrow1.22692548
79MP0005000_abnormal_immune_tolerance1.21434160
80MP0005058_abnormal_lysosome_morphology1.21292721
81MP0002722_abnormal_immune_system1.19566437
82MP0010155_abnormal_intestine_physiology1.18074660
83MP0009785_altered_susceptibility_to1.18032369
84MP0005551_abnormal_eye_electrophysiolog1.17422140
85MP0009643_abnormal_urine_homeostasis1.17294853
86MP0002419_abnormal_innate_immunity1.17250232
87MP0000598_abnormal_liver_morphology1.15932929
88MP0001853_heart_inflammation1.15897520
89MP0000049_abnormal_middle_ear1.15888078
90MP0002420_abnormal_adaptive_immunity1.15200290
91MP0001819_abnormal_immune_cell1.14157626
92MP0001845_abnormal_inflammatory_respons1.13392748
93MP0006082_CNS_inflammation1.12527928
94MP0000490_abnormal_crypts_of1.10465482
95MP0002118_abnormal_lipid_homeostasis1.09500112
96MP0003718_maternal_effect1.08510403
97MP0002282_abnormal_trachea_morphology1.08351799
98MP0000716_abnormal_immune_system1.08149905
99MP0001984_abnormal_olfaction1.07058923
100MP0001873_stomach_inflammation1.06200458
101MP0002429_abnormal_blood_cell1.05662160
102MP0004019_abnormal_vitamin_homeostasis1.04592546
103MP0003566_abnormal_cell_adhesion1.03304202
104MP0002396_abnormal_hematopoietic_system1.01681802
105MP0005257_abnormal_intraocular_pressure1.01438280
106MP0002254_reproductive_system_inflammat0.99910988
107MP0006276_abnormal_autonomic_nervous0.99854411
108MP0003453_abnormal_keratinocyte_physiol0.99106310
109MP0010386_abnormal_urinary_bladder0.98942992
110MP0000026_abnormal_inner_ear0.98498371
111MP0000778_abnormal_nervous_system0.97555064
112MP0004185_abnormal_adipocyte_glucose0.95946776
113MP0005023_abnormal_wound_healing0.95854386
114MP0005646_abnormal_pituitary_gland0.95686826
115MP0005670_abnormal_white_adipose0.95410981
116MP0005076_abnormal_cell_differentiation0.95296353
117MP0005410_abnormal_fertilization0.95280423
118MP0002132_abnormal_respiratory_system0.93500190
119MP0000465_gastrointestinal_hemorrhage0.93085661
120MP0010030_abnormal_orbit_morphology0.93015713
121MP0005167_abnormal_blood-brain_barrier0.92895305
122MP0008872_abnormal_physiological_respon0.92801173
123MP0005499_abnormal_olfactory_system0.92794851
124MP0005394_taste/olfaction_phenotype0.92794851
125MP0003724_increased_susceptibility_to0.92662322
126MP0006054_spinal_hemorrhage0.92628323
127MP0002234_abnormal_pharynx_morphology0.92318310
128MP0009763_increased_sensitivity_to0.91597008
129MP0001905_abnormal_dopamine_level0.91225183
130MP0005377_hearing/vestibular/ear_phenot0.91062542
131MP0003878_abnormal_ear_physiology0.91062542
132MP0005195_abnormal_posterior_eye0.90853816
133MP0003693_abnormal_embryo_hatching0.90671990
134MP0001485_abnormal_pinna_reflex0.90262452
135MP0005584_abnormal_enzyme/coenzyme_acti0.90172950
136MP0000647_abnormal_sebaceous_gland0.89977337
137MP0005389_reproductive_system_phenotype0.88319922
138MP0005671_abnormal_response_to0.88159196
139MP0008961_abnormal_basal_metabolism0.87438908
140MP0003011_delayed_dark_adaptation0.86929845
141MP0000858_altered_metastatic_potential0.86705917
142MP0000703_abnormal_thymus_morphology0.85801694
143MP0002638_abnormal_pupillary_reflex0.85383402
144MP0001533_abnormal_skeleton_physiology0.84830995
145MP0003938_abnormal_ear_development0.84319391
146MP0009053_abnormal_anal_canal0.83579035
147MP0001663_abnormal_digestive_system0.83358695
148MP0009765_abnormal_xenobiotic_induced0.83272485
149MP0003866_abnormal_defecation0.82752560
150MP0002796_impaired_skin_barrier0.81547266
151MP0002060_abnormal_skin_morphology0.80964184
152MP0003186_abnormal_redox_activity0.80693077
153MP0002019_abnormal_tumor_incidence0.80119270
154MP0009931_abnormal_skin_appearance0.79811688
155MP0002136_abnormal_kidney_physiology0.79602229
156MP0005391_vision/eye_phenotype0.79082738
157MP0001243_abnormal_dermal_layer0.78327357
158MP0000604_amyloidosis0.77899593
159MP0001963_abnormal_hearing_physiology0.77212362
160MP0005220_abnormal_exocrine_pancreas0.75641096
161MP0002557_abnormal_social/conspecific_i0.74923204
162MP0001764_abnormal_homeostasis0.74536299
163MP0005636_abnormal_mineral_homeostasis0.73662476
164MP0006036_abnormal_mitochondrial_physio0.72113595
165MP0004808_abnormal_hematopoietic_stem0.71762720
166MP0003195_calcinosis0.71740623
167MP0004957_abnormal_blastocyst_morpholog0.71592838

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.22300192
2Xanthomatosis (HP:0000991)4.19894280
3Deep venous thrombosis (HP:0002625)4.19578171
4Mitochondrial inheritance (HP:0001427)3.97922140
5Acute necrotizing encephalopathy (HP:0006965)3.93536103
6Pancreatic cysts (HP:0001737)3.73017645
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.65046650
8Abnormality of midbrain morphology (HP:0002418)3.58167527
9Molar tooth sign on MRI (HP:0002419)3.58167527
10True hermaphroditism (HP:0010459)3.50576686
11Intrahepatic cholestasis (HP:0001406)3.50312274
12Hypobetalipoproteinemia (HP:0003563)3.49444780
13Pancreatic fibrosis (HP:0100732)3.47324601
14Abnormal mitochondria in muscle tissue (HP:0008316)3.42482935
15Hepatocellular necrosis (HP:0001404)3.42158624
16Acute encephalopathy (HP:0006846)3.41962029
17Abnormality of glycolipid metabolism (HP:0010969)3.40758580
18Abnormality of liposaccharide metabolism (HP:0010968)3.40758580
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.40758580
20Polyphagia (HP:0002591)3.32639051
21Increased CSF lactate (HP:0002490)3.30135636
22Myocardial infarction (HP:0001658)3.27410271
23Nasal polyposis (HP:0100582)3.24820583
24Hepatic necrosis (HP:0002605)3.24239652
25Type II lissencephaly (HP:0007260)3.20390123
26Increased hepatocellular lipid droplets (HP:0006565)3.14949162
27Lipid accumulation in hepatocytes (HP:0006561)3.12738977
28Renal Fanconi syndrome (HP:0001994)3.11983978
293-Methylglutaconic aciduria (HP:0003535)3.09344634
30Elevated erythrocyte sedimentation rate (HP:0003565)3.04436012
31Progressive macrocephaly (HP:0004481)3.03810773
32Hyperlipoproteinemia (HP:0010980)3.03447484
33Vacuolated lymphocytes (HP:0001922)3.03293851
34Abnormality of the nasal mucosa (HP:0000433)2.92671953
35Hyperammonemia (HP:0001987)2.84440248
36Increased serum ferritin (HP:0003281)2.84058626
37Sclerocornea (HP:0000647)2.83962140
38Abnormality of complement system (HP:0005339)2.76268748
39Ketosis (HP:0001946)2.75238165
40Polycythemia (HP:0001901)2.75133941
41Nephronophthisis (HP:0000090)2.73558671
42Complement deficiency (HP:0004431)2.72986898
43Joint hemorrhage (HP:0005261)2.71791242
44Hypolipoproteinemia (HP:0010981)2.69347356
45Pustule (HP:0200039)2.68384023
46Eczematoid dermatitis (HP:0000976)2.66444246
47Colitis (HP:0002583)2.65775266
48Abnormality of transition element cation homeostasis (HP:0011030)2.64555123
49Prolonged partial thromboplastin time (HP:0003645)2.61657316
50Abnormality of iron homeostasis (HP:0011031)2.60492571
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60291334
52Cerebral edema (HP:0002181)2.58967630
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58029919
54Abnormality of cells of the erythroid lineage (HP:0012130)2.56960184
55Increased intramyocellular lipid droplets (HP:0012240)2.56089470
56Exertional dyspnea (HP:0002875)2.55853565
57Abnormal number of erythroid precursors (HP:0012131)2.55618798
58Abnormality of the common coagulation pathway (HP:0010990)2.54099296
59Microretrognathia (HP:0000308)2.50925403
60Recurrent gram-negative bacterial infections (HP:0005420)2.50650440
61Stomatitis (HP:0010280)2.50131201
62Reticulocytosis (HP:0001923)2.49917190
63Retinal dysplasia (HP:0007973)2.48099889
64Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46850277
65Autoimmune thrombocytopenia (HP:0001973)2.42849540
66Hypercholesterolemia (HP:0003124)2.42631598
67Medial flaring of the eyebrow (HP:0010747)2.42538981
68Hypoalphalipoproteinemia (HP:0003233)2.41443091
69Gastrointestinal inflammation (HP:0004386)2.40095847
70Prolonged neonatal jaundice (HP:0006579)2.38086319
71Pendular nystagmus (HP:0012043)2.37306022
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.36653995
73Anencephaly (HP:0002323)2.36532587
74Cystic liver disease (HP:0006706)2.32344477
75Optic disc pallor (HP:0000543)2.31527130
76Abnormal platelet function (HP:0011869)2.30240901
77Impaired platelet aggregation (HP:0003540)2.30240901
78Inflammation of the large intestine (HP:0002037)2.29990090
79Recurrent viral infections (HP:0004429)2.27934356
80Increased muscle lipid content (HP:0009058)2.27858451
81Lactic acidosis (HP:0003128)2.27178844
82Hyperglycinuria (HP:0003108)2.26252696
83Late onset (HP:0003584)2.25750257
84Congenital stationary night blindness (HP:0007642)2.25306241
85Systemic lupus erythematosus (HP:0002725)2.24259133
86Chronic hepatic failure (HP:0100626)2.23451715
87Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21588433
88Abnormal rod and cone electroretinograms (HP:0008323)2.21540086
89Abnormality of the renal medulla (HP:0100957)2.21518258
90Abnormal biliary tract physiology (HP:0012439)2.20924609
91Bile duct proliferation (HP:0001408)2.20924609
92Increased serum lactate (HP:0002151)2.19937900
93Peritonitis (HP:0002586)2.19665452
94Pachygyria (HP:0001302)2.18358624
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.18170499
96Abnormality of pyrimidine metabolism (HP:0004353)2.17478594
97Spastic diplegia (HP:0001264)2.16953202
98Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16606765
99Acanthocytosis (HP:0001927)2.15225921
100Abnormality of glycine metabolism (HP:0010895)2.14895148
101Abnormality of serine family amino acid metabolism (HP:0010894)2.14895148
102Abnormality of reticulocytes (HP:0004312)2.14388441
103Hyperbilirubinemia (HP:0002904)2.13868780
104Respiratory failure (HP:0002878)2.13832352
105Menorrhagia (HP:0000132)2.13620689
106Abnormality of the Achilles tendon (HP:0005109)2.13409766
107Abnormality of the labia minora (HP:0012880)2.12753511
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12742312
109Lissencephaly (HP:0001339)2.11743609
110Abnormality of fatty-acid metabolism (HP:0004359)2.11056929
111Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10966568
112Urticaria (HP:0001025)2.10166615
113Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08882925
114Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08882925
115Epistaxis (HP:0000421)2.08485892
116Poikilocytosis (HP:0004447)2.08070969
117Abnormal platelet volume (HP:0011876)2.07969438
118Agitation (HP:0000713)2.07697947
119Abnormality of nucleobase metabolism (HP:0010932)2.07169439
120Recurrent fungal infections (HP:0002841)2.07116513
121Hypoglycemic coma (HP:0001325)2.06822281
122Lethargy (HP:0001254)2.06471059
123Chronic otitis media (HP:0000389)2.05984438
124IgM deficiency (HP:0002850)2.05850021
125Esophageal varix (HP:0002040)2.05527857
126Gingival bleeding (HP:0000225)2.04827628
127Recurrent bronchitis (HP:0002837)2.04043509
128Abnormality of urine glucose concentration (HP:0011016)2.03529928
129Glycosuria (HP:0003076)2.03529928
130Abnormality of T cell physiology (HP:0011840)2.02442840
131Recurrent bacterial skin infections (HP:0005406)2.02117262
132Abnormality of purine metabolism (HP:0004352)2.02014862
133Hyperglycinemia (HP:0002154)2.01949021
134Anophthalmia (HP:0000528)2.01697145
135Occipital encephalocele (HP:0002085)2.01186809
136Abnormal respiratory epithelium morphology (HP:0012253)2.00948717
137Abnormal respiratory motile cilium morphology (HP:0005938)2.00948717
138Malnutrition (HP:0004395)2.00150124
139Increased mean platelet volume (HP:0011877)1.99437795
140Mesangial abnormality (HP:0001966)1.99078860
141Reticulocytopenia (HP:0001896)1.98739875
142Ketoacidosis (HP:0001993)1.98346266
143Fat malabsorption (HP:0002630)1.97760160
144Epidermoid cyst (HP:0200040)1.95432203
145Septo-optic dysplasia (HP:0100842)1.95229834
146Thrombocytosis (HP:0001894)1.93857582
147Abnormality of renal resorption (HP:0011038)1.93792961
148Methylmalonic aciduria (HP:0012120)1.93354725
149Abnormality of the intrinsic pathway (HP:0010989)1.92177344
150Vascular calcification (HP:0004934)1.92088739
151CNS demyelination (HP:0007305)1.90979611
152Cellulitis (HP:0100658)1.90394200
153Interstitial pulmonary disease (HP:0006530)1.89997012
154Abolished electroretinogram (ERG) (HP:0000550)1.88962428
155Aplasia/hypoplasia of the uterus (HP:0008684)1.88659049
156Congenital hepatic fibrosis (HP:0002612)1.88536169
157Male pseudohermaphroditism (HP:0000037)1.88496892
158Recurrent abscess formation (HP:0002722)1.87748120
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.86210538
160Panhypogammaglobulinemia (HP:0003139)1.85691575
161Generalized aminoaciduria (HP:0002909)1.85320252
162Optic neuritis (HP:0100653)1.83911510
163Retrobulbar optic neuritis (HP:0100654)1.83911510
164Recurrent skin infections (HP:0001581)1.83170619
165Hemorrhage of the eye (HP:0011885)1.83028599
166Thrombophlebitis (HP:0004418)1.82976449
167Petechiae (HP:0000967)1.82389908
168Mitral stenosis (HP:0001718)1.81658137
169Dicarboxylic aciduria (HP:0003215)1.81449144
170Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81449144
171Increased corneal curvature (HP:0100692)1.81189911
172Keratoconus (HP:0000563)1.81189911
173Achilles tendon contracture (HP:0001771)1.81153003
174Multiple enchondromatosis (HP:0005701)1.80602472
175Verrucae (HP:0200043)1.78195471
176Papilloma (HP:0012740)1.78195471
177Hypertriglyceridemia (HP:0002155)1.77934838
178Respiratory difficulties (HP:0002880)1.77900350
179Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77308280
180Glomerulonephritis (HP:0000099)1.76425437
181Ulnar bowing (HP:0003031)1.75693696
182Abnormality of the renal cortex (HP:0011035)1.75622913
183Disproportionate short-trunk short stature (HP:0003521)1.72370911
184Mutism (HP:0002300)1.72217767
185Cerebellar dysplasia (HP:0007033)1.70617264
186Delayed CNS myelination (HP:0002188)1.69851050
187Concave nail (HP:0001598)1.69817968
188Flat capital femoral epiphysis (HP:0003370)1.68779806
189Orchitis (HP:0100796)1.68124326
190Tubular atrophy (HP:0000092)1.66472208
191Postaxial foot polydactyly (HP:0001830)1.65530016
192Oculomotor apraxia (HP:0000657)1.64240872
193Congenital primary aphakia (HP:0007707)1.62764283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.73104632
2ERN13.65531626
3MAP3K103.64906671
4MAP4K13.50397233
5MAP4K23.42503771
6ADRBK23.29158525
7EEF2K2.79042106
8PKN22.64510561
9NME22.57591708
10VRK22.38599669
11ZAK2.36253719
12BCKDK2.33911777
13PINK12.29809413
14NUAK12.16345735
15DYRK22.11962741
16GRK12.11235450
17GRK62.01210704
18MAP3K111.99848313
19GRK71.99560449
20CDK191.98590960
21WNK31.95289161
22TBK11.94190531
23STK161.92624695
24CASK1.92025744
25SIK11.86856646
26FGFR41.86656279
27VRK11.83701288
28ICK1.80804746
29TYK21.80782194
30STK101.75517013
31ZAP701.74518926
32BMPR1B1.69027036
33ACVR1B1.67929621
34MAP3K31.63216161
35LIMK11.56247473
36KDR1.54938762
37MAP2K31.53373117
38NEK21.53168125
39FRK1.50297116
40LRRK21.45278114
41RPS6KA41.43252796
42EPHB21.41268053
43CDK121.37566590
44PTK61.36935797
45WNK41.34439577
46INSRR1.33512779
47BLK1.29836567
48TNIK1.28963518
49TRIM281.28732795
50PDK21.25708249
51IKBKE1.25144320
52MATK1.21836253
53EPHB11.19720965
54BTK1.19675504
55TTN1.19143147
56CSK1.18773305
57MAP2K21.17061364
58TAOK31.15474430
59DYRK31.15334545
60CSNK1G21.15291018
61CDK41.14445032
62CSNK1G31.13753341
63MAPK111.13440243
64PIM11.10430384
65DYRK1B1.09144083
66JAK31.08932601
67FLT31.07522606
68TESK11.07086876
69TESK21.06129293
70PIM21.06029384
71CSF1R0.98767273
72TXK0.97673882
73TGFBR10.96558993
74CSNK1G10.96330449
75IKBKB0.92703522
76TGFBR20.91591108
77MAP3K80.91235623
78ADRBK10.90594315
79PKN10.86393156
80MAP2K70.86166983
81CSNK1A1L0.84564830
82BCR0.84353832
83RPS6KB20.82699205
84SIK20.82228674
85MAPK130.81881067
86KIT0.80878847
87BMX0.80798158
88CDK60.79769468
89CHUK0.79071777
90MAP3K140.78005417
91LMTK20.77779777
92TAOK10.77604382
93MAPKAPK30.76100024
94NME10.74066801
95PAK40.73808489
96RPS6KA50.72914557
97JAK20.72910142
98ITK0.72857819
99STK40.72009781
100CDK70.70751592
101PRKCG0.69910588
102SYK0.69478824
103IRAK30.69467722
104MTOR0.68729592
105RIPK10.68536850
106LCK0.67562390
107IRAK10.63291374
108MST1R0.62172119
109TLK10.61039088
110ARAF0.61031303
111HCK0.57970331
112MAPK40.57066281
113PIK3CA0.56338798
114SCYL20.56246746
115PRKCE0.55804365
116HIPK20.55791845
117RPS6KA60.55620746
118DAPK20.54911559
119MAP3K70.54591928
120BUB10.54312490
121DAPK30.52748313
122TAOK20.52475212
123PASK0.52449470
124MAP3K40.51962866
125NLK0.51277124
126PAK20.51039573
127JAK10.50833126
128CLK10.49267400
129RPS6KA10.48479842
130LYN0.48190594
131PLK10.47750023
132PRKACA0.47714465
133RPS6KC10.47497131
134RPS6KL10.47497131
135ILK0.47385335
136MARK30.47233538
137AURKA0.47203229
138MAPKAPK20.46038197
139PAK30.45981459
140IRAK40.45483242
141PRKCQ0.44295430
142TEC0.43557005
143CSNK2A10.41885524
144PRKG20.39289570
145OXSR10.38665644
146CSNK1A10.37436284
147PRKCD0.37242909
148NTRK20.36966405
149DDR20.36912811
150CDC70.36438688
151CCNB10.36049836
152MAPK150.35630978
153TIE10.33125003
154MAP3K120.32277452
155PRKD20.32230302
156MAP2K60.31914378
157PTK20.31188712
158PRKCI0.31158534
159MARK10.30656233
160CAMK1D0.30487032
161GSK3A0.30295197
162MAP3K10.30135483
163AKT20.29784966
164EGFR0.29045743
165PDK10.28629393
166PHKG20.28428351
167PHKG10.28428351
168EPHA30.27877342
169ABL20.27741511

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.84913645
2Parkinsons disease_Homo sapiens_hsa050123.07799996
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.83985377
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50362541
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.31695673
6Protein export_Homo sapiens_hsa030602.30975741
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23144184
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18653368
9Fatty acid degradation_Homo sapiens_hsa000712.10360259
10Sulfur relay system_Homo sapiens_hsa041222.08749002
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.05051475
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94490722
13Huntingtons disease_Homo sapiens_hsa050161.93627667
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.90931180
15Folate biosynthesis_Homo sapiens_hsa007901.89915932
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89046755
17Tryptophan metabolism_Homo sapiens_hsa003801.88124990
18Staphylococcus aureus infection_Homo sapiens_hsa051501.87453044
19Selenocompound metabolism_Homo sapiens_hsa004501.86462328
20Complement and coagulation cascades_Homo sapiens_hsa046101.86072489
21Alzheimers disease_Homo sapiens_hsa050101.85209917
22Arginine biosynthesis_Homo sapiens_hsa002201.84588252
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72953321
24Caffeine metabolism_Homo sapiens_hsa002321.70824402
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70151618
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69652562
27RNA polymerase_Homo sapiens_hsa030201.67900166
28Asthma_Homo sapiens_hsa053101.67847401
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.62517834
30Rheumatoid arthritis_Homo sapiens_hsa053231.61494812
31Proteasome_Homo sapiens_hsa030501.60409833
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58951167
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55531214
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55147285
35Collecting duct acid secretion_Homo sapiens_hsa049661.54332373
36PPAR signaling pathway_Homo sapiens_hsa033201.51726077
37Steroid biosynthesis_Homo sapiens_hsa001001.51067777
38Fatty acid metabolism_Homo sapiens_hsa012121.50726724
39Biosynthesis of amino acids_Homo sapiens_hsa012301.49230854
40Fat digestion and absorption_Homo sapiens_hsa049751.43831193
41Pentose phosphate pathway_Homo sapiens_hsa000301.43498285
42Peroxisome_Homo sapiens_hsa041461.41475844
43Lysosome_Homo sapiens_hsa041421.40264528
44Nitrogen metabolism_Homo sapiens_hsa009101.38120387
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37195004
46Carbon metabolism_Homo sapiens_hsa012001.35001200
47One carbon pool by folate_Homo sapiens_hsa006701.32992214
48DNA replication_Homo sapiens_hsa030301.31743124
49Histidine metabolism_Homo sapiens_hsa003401.31372466
50Ribosome_Homo sapiens_hsa030101.31221058
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31201596
52Cardiac muscle contraction_Homo sapiens_hsa042601.28698452
53Primary immunodeficiency_Homo sapiens_hsa053401.27493263
54Allograft rejection_Homo sapiens_hsa053301.24261745
55Propanoate metabolism_Homo sapiens_hsa006401.23823623
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17095503
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13182974
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.12155554
59Homologous recombination_Homo sapiens_hsa034401.10867389
60Pyruvate metabolism_Homo sapiens_hsa006201.08693389
61Phototransduction_Homo sapiens_hsa047441.08186418
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08136665
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05368713
64Chemical carcinogenesis_Homo sapiens_hsa052041.03603673
65Linoleic acid metabolism_Homo sapiens_hsa005911.02120731
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01420809
67Lysine degradation_Homo sapiens_hsa003101.00038166
68Arginine and proline metabolism_Homo sapiens_hsa003300.98370590
69Antigen processing and presentation_Homo sapiens_hsa046120.98297085
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97503432
71Arachidonic acid metabolism_Homo sapiens_hsa005900.95826527
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94564412
73Autoimmune thyroid disease_Homo sapiens_hsa053200.94321981
74beta-Alanine metabolism_Homo sapiens_hsa004100.93224229
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92865808
76B cell receptor signaling pathway_Homo sapiens_hsa046620.91987106
77Metabolic pathways_Homo sapiens_hsa011000.88953995
78Basal transcription factors_Homo sapiens_hsa030220.88457324
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88431824
80Base excision repair_Homo sapiens_hsa034100.87920977
81Phenylalanine metabolism_Homo sapiens_hsa003600.87839914
82Leishmaniasis_Homo sapiens_hsa051400.86760997
83Graft-versus-host disease_Homo sapiens_hsa053320.86171967
84ABC transporters_Homo sapiens_hsa020100.85248821
85Legionellosis_Homo sapiens_hsa051340.83924679
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82132720
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.80891445
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80381653
89Fanconi anemia pathway_Homo sapiens_hsa034600.80276639
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.80250690
91Starch and sucrose metabolism_Homo sapiens_hsa005000.79343976
92Bile secretion_Homo sapiens_hsa049760.78875685
93Acute myeloid leukemia_Homo sapiens_hsa052210.78258290
94Fatty acid biosynthesis_Homo sapiens_hsa000610.75638188
95Fructose and mannose metabolism_Homo sapiens_hsa000510.75266041
96Glutathione metabolism_Homo sapiens_hsa004800.74798454
97Retinol metabolism_Homo sapiens_hsa008300.74128209
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73030160
99Osteoclast differentiation_Homo sapiens_hsa043800.72994647
100Measles_Homo sapiens_hsa051620.69038195
101Other glycan degradation_Homo sapiens_hsa005110.67918295
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.67394184
103Butanoate metabolism_Homo sapiens_hsa006500.66932367
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.66756854
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66339780
106Fatty acid elongation_Homo sapiens_hsa000620.66262144
107Sulfur metabolism_Homo sapiens_hsa009200.66077269
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64590926
109Galactose metabolism_Homo sapiens_hsa000520.63672174
110Glycerolipid metabolism_Homo sapiens_hsa005610.62663271
111Type I diabetes mellitus_Homo sapiens_hsa049400.61493383
112Herpes simplex infection_Homo sapiens_hsa051680.60906964
113Systemic lupus erythematosus_Homo sapiens_hsa053220.59761040
114Chronic myeloid leukemia_Homo sapiens_hsa052200.59647393
115Phagosome_Homo sapiens_hsa041450.59115218
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58154866
117Apoptosis_Homo sapiens_hsa042100.57197828
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.56615247
119Insulin resistance_Homo sapiens_hsa049310.56470563
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.54418285
121Toxoplasmosis_Homo sapiens_hsa051450.51524798
122Vitamin digestion and absorption_Homo sapiens_hsa049770.51245605
123Bladder cancer_Homo sapiens_hsa052190.51137143
124Notch signaling pathway_Homo sapiens_hsa043300.50338770
125Mismatch repair_Homo sapiens_hsa034300.50313610
126Small cell lung cancer_Homo sapiens_hsa052220.50267373
127Hematopoietic cell lineage_Homo sapiens_hsa046400.50008352
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48744765
129Tyrosine metabolism_Homo sapiens_hsa003500.48338054
130Shigellosis_Homo sapiens_hsa051310.48256737
131Malaria_Homo sapiens_hsa051440.46915479
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46900171
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46235201
134Purine metabolism_Homo sapiens_hsa002300.45661901
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45568298
136Ether lipid metabolism_Homo sapiens_hsa005650.45488366
137Ovarian steroidogenesis_Homo sapiens_hsa049130.43778511
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43284365
139Influenza A_Homo sapiens_hsa051640.42781332
140Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42271446
141Vibrio cholerae infection_Homo sapiens_hsa051100.41564661
142Pyrimidine metabolism_Homo sapiens_hsa002400.41536639
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41124972
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40728611
145African trypanosomiasis_Homo sapiens_hsa051430.39917840
146Pertussis_Homo sapiens_hsa051330.39865820
147Basal cell carcinoma_Homo sapiens_hsa052170.39799480
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39419705
149Mineral absorption_Homo sapiens_hsa049780.38723303
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37664150

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