DHRS9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)8.43816268
2motile cilium assembly (GO:0044458)8.33264327
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.56150474
4epithelial cilium movement (GO:0003351)7.13232596
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.15968656
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.15968656
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.15968656
8modulation by symbiont of host immune response (GO:0052553)6.15968656
9positive regulation by symbiont of host defense response (GO:0052509)6.15968656
10modulation by symbiont of host defense response (GO:0052031)6.15968656
11neutrophil activation involved in immune response (GO:0002283)5.77357361
12axoneme assembly (GO:0035082)5.49600220
13primary alcohol catabolic process (GO:0034310)5.48651063
14response to host immune response (GO:0052572)5.11221861
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.11221861
16response to peptidoglycan (GO:0032494)5.02595513
17pyrimidine-containing compound transmembrane transport (GO:0072531)4.93184867
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.86889830
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.78297387
20cellular extravasation (GO:0045123)4.72353193
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.59926215
22response to host (GO:0075136)4.59926215
23response to host defenses (GO:0052200)4.59926215
24regulation of interferon-beta biosynthetic process (GO:0045357)4.57936675
25ethanol metabolic process (GO:0006067)4.55783115
26neutrophil activation (GO:0042119)4.55312226
27neutrophil mediated immunity (GO:0002446)4.55309212
28left/right pattern formation (GO:0060972)4.50037314
29tolerance induction (GO:0002507)4.44476878
30production of molecular mediator involved in inflammatory response (GO:0002532)4.43625787
31vitamin transmembrane transport (GO:0035461)4.35945021
32granulocyte activation (GO:0036230)4.34201233
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.33405497
34respiratory burst (GO:0045730)4.32644764
35regulation of B cell receptor signaling pathway (GO:0050855)4.29389943
36response to xenobiotic stimulus (GO:0009410)4.16679832
37leukocyte aggregation (GO:0070486)4.16215814
38detection of other organism (GO:0098543)4.14304242
39macrophage activation involved in immune response (GO:0002281)4.13029559
40superoxide anion generation (GO:0042554)4.12725226
41regulation of cilium movement (GO:0003352)4.04713508
42negative regulation of mast cell activation (GO:0033004)3.96391861
43negative regulation of B cell mediated immunity (GO:0002713)3.96245451
44negative regulation of immunoglobulin mediated immune response (GO:0002890)3.96245451
45positive regulation of tolerance induction (GO:0002645)3.95883533
46detection of molecule of bacterial origin (GO:0032490)3.94018315
47positive regulation of interferon-alpha production (GO:0032727)3.93952442
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.92746198
49positive regulation of mast cell activation (GO:0033005)3.91131582
50negative regulation of humoral immune response (GO:0002921)3.83533867
51regulation of mast cell activation (GO:0033003)3.83129424
52ethanol oxidation (GO:0006069)3.82912137
53regulation of tolerance induction (GO:0002643)3.80507316
54immunoglobulin mediated immune response (GO:0016064)3.75950078
55positive regulation of cellular amide metabolic process (GO:0034250)3.73652147
56regulation of germinal center formation (GO:0002634)3.72656587
57regulation of interferon-alpha production (GO:0032647)3.70605811
58myeloid leukocyte mediated immunity (GO:0002444)3.63369788
59one-carbon compound transport (GO:0019755)3.62320191
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60892440
61O-glycan processing (GO:0016266)3.59196482
62regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.57487453
63leukocyte migration involved in inflammatory response (GO:0002523)3.57143148
64antigen processing and presentation of endogenous antigen (GO:0019883)3.56509001
65left/right axis specification (GO:0070986)3.49356183
66neutrophil chemotaxis (GO:0030593)3.49310327
67Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47140978
68microglial cell activation (GO:0001774)3.45058069
69detection of external biotic stimulus (GO:0098581)3.40922250
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38916941
71hypotonic response (GO:0006971)3.38824394
72neutrophil migration (GO:1990266)3.37870585
73sperm capacitation (GO:0048240)3.33608791
74positive regulation of monocyte chemotaxis (GO:0090026)3.31255101
75negative regulation of lymphocyte mediated immunity (GO:0002707)3.30034842
76positive regulation of antigen processing and presentation (GO:0002579)3.29583530
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.28387504
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28240368
79regulation of mast cell degranulation (GO:0043304)3.23287133
80macrophage activation (GO:0042116)3.21418163
81myeloid cell activation involved in immune response (GO:0002275)3.20828987
82regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.20474052
83detection of bacterium (GO:0016045)3.17805949
84regulation of cholesterol storage (GO:0010885)3.17238906
85T-helper 1 type immune response (GO:0042088)3.16272154
86response to fungus (GO:0009620)3.15205978
87phagosome maturation (GO:0090382)3.13974699
88ventricular system development (GO:0021591)3.13939861
89regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13638013
90regulation of mast cell activation involved in immune response (GO:0033006)3.11803002
91wound healing, spreading of epidermal cells (GO:0035313)3.09644849
92regulation of mononuclear cell migration (GO:0071675)3.08102005
93regulation of interleukin-5 production (GO:0032674)3.07687926
94positive regulation of toll-like receptor signaling pathway (GO:0034123)3.05342112
95microtubule bundle formation (GO:0001578)3.05277758
96granulocyte chemotaxis (GO:0071621)3.04355990
97negative regulation of interleukin-17 production (GO:0032700)3.04070070
98dendritic cell migration (GO:0036336)3.01730079
99detection of biotic stimulus (GO:0009595)3.00954688
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.00308651
101hydrogen peroxide biosynthetic process (GO:0050665)2.99069102
102reactive oxygen species biosynthetic process (GO:1903409)2.96582226
103positive regulation of gamma-delta T cell activation (GO:0046645)2.96119887
104response to muramyl dipeptide (GO:0032495)2.95664770
105regulation of interleukin-13 production (GO:0032656)2.94988876
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94566553
107regulation of leukocyte degranulation (GO:0043300)2.92343910
108granulocyte migration (GO:0097530)2.91902815
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91408124
110regulation of interleukin-6 biosynthetic process (GO:0045408)2.91305605
111regulation of activation of Janus kinase activity (GO:0010533)2.90041009
112endodermal cell differentiation (GO:0035987)2.88780211
113regulation of antigen processing and presentation (GO:0002577)2.88675762
114lipoxygenase pathway (GO:0019372)2.88227972
115low-density lipoprotein particle clearance (GO:0034383)2.87770874
116negative regulation of adaptive immune response (GO:0002820)2.86752518
117macrophage differentiation (GO:0030225)2.85690020
118positive regulation of macrophage cytokine production (GO:0060907)2.85621729
119natural killer cell mediated immunity (GO:0002228)2.85158168
120natural killer cell mediated cytotoxicity (GO:0042267)2.85158168
121actin nucleation (GO:0045010)2.83582653
122regulation of monocyte chemotaxis (GO:0090025)2.82965451
123negative regulation of leukocyte mediated immunity (GO:0002704)2.82227434
124germinal center formation (GO:0002467)2.81794844
125B cell mediated immunity (GO:0019724)2.80412646
126dendritic cell chemotaxis (GO:0002407)2.79158805
127positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.78530860
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.77466959
129positive regulation of mast cell activation involved in immune response (GO:0033008)2.77321430
130positive regulation of mast cell degranulation (GO:0043306)2.77321430
131regulation of myeloid cell apoptotic process (GO:0033032)2.75332187
132phagocytosis, recognition (GO:0006910)2.74786869
133response to type I interferon (GO:0034340)2.74596486
134negative regulation of toll-like receptor signaling pathway (GO:0034122)2.74546672
135type I interferon signaling pathway (GO:0060337)2.73462515
136cellular response to type I interferon (GO:0071357)2.73462515
137oligosaccharide biosynthetic process (GO:0009312)2.73393030
138multicellular organismal water homeostasis (GO:0050891)2.71819569
139myeloid leukocyte activation (GO:0002274)2.71104036
140positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70688003
141negative regulation of lipid storage (GO:0010888)2.67592866
142negative regulation of myeloid cell apoptotic process (GO:0033033)2.66367870
143leukocyte cell-cell adhesion (GO:0007159)2.65244146
144iron ion import (GO:0097286)2.64251845
145leukocyte mediated cytotoxicity (GO:0001909)2.64207255
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.64153967
147wound healing, spreading of cells (GO:0044319)2.63728638
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.63684158
149negative regulation of cell killing (GO:0031342)2.63684158
150maintenance of gastrointestinal epithelium (GO:0030277)2.60752247
151cilium organization (GO:0044782)2.59607547
152negative regulation of interleukin-12 production (GO:0032695)2.59494853
153negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.57119162
154interferon-gamma-mediated signaling pathway (GO:0060333)2.56596565
155negative regulation of T cell differentiation in thymus (GO:0033085)2.53339114
156cilium assembly (GO:0042384)2.49604324
157negative regulation of interleukin-6 production (GO:0032715)2.48428334
158intraciliary transport (GO:0042073)2.46706195
159glomerular epithelial cell development (GO:0072310)2.45625430
160regulation of toll-like receptor signaling pathway (GO:0034121)2.42200296
161water homeostasis (GO:0030104)2.39720528
162amyloid precursor protein catabolic process (GO:0042987)2.39595370
163axonemal dynein complex assembly (GO:0070286)12.3215219
164cilium or flagellum-dependent cell motility (GO:0001539)10.2102452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.12020788
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.99383804
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.54453505
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.34568702
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.12805509
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.07509742
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.82664008
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63027013
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41945171
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.31497495
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29789290
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77291945
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76190163
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67603912
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.64504482
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57702693
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.30669348
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25938221
19SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09178682
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05497407
21* VDR_24787735_ChIP-Seq_THP-1_Human2.05275917
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.03194583
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98417130
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95915554
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95511320
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93308068
27* SPI1_23547873_ChIP-Seq_NB4_Human1.93286897
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90820002
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88798271
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.83404180
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.81099119
32PU_27001747_Chip-Seq_BMDM_Mouse1.79446493
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78118601
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.74193370
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.73211552
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70870276
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.66929489
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66579842
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.66122494
40RUNX_20019798_ChIP-Seq_JUKART_Human1.63433068
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.60419321
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59877333
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.59296980
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54386343
45DROSHA_22980978_ChIP-Seq_HELA_Human1.53440728
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52069915
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51791776
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.51340359
49GATA1_19941826_ChIP-Seq_K562_Human1.51109250
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50345159
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.47321092
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47186570
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47186570
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45812333
55STAT1_20625510_ChIP-Seq_HELA_Human1.44232221
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44077420
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42969017
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42969017
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41061432
60* SPI1_23127762_ChIP-Seq_K562_Human1.40437610
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38344840
62MYB_26560356_Chip-Seq_TH2_Human1.36973733
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36445005
64VDR_24763502_ChIP-Seq_THP-1_Human1.35484320
65KLF5_25053715_ChIP-Seq_YYC3_Human1.32907102
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32234082
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31224202
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30245760
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30021612
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29794937
71SCL_19346495_ChIP-Seq_HPC-7_Human1.28630435
72* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28436571
73CJUN_26792858_Chip-Seq_BT549_Human1.28036525
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27634850
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26573106
76* SOX2_20726797_ChIP-Seq_SW620_Human1.25052246
77RACK7_27058665_Chip-Seq_MCF-7_Human1.22851226
78AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21868633
79VDR_21846776_ChIP-Seq_THP-1_Human1.21118039
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20361651
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16846871
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16340367
83AHR_22903824_ChIP-Seq_MCF-7_Human1.15652711
84RXR_22108803_ChIP-Seq_LS180_Human1.14072340
85GATA3_26560356_Chip-Seq_TH2_Human1.13783225
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13548610
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.12995992
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12813001
89MYB_26560356_Chip-Seq_TH1_Human1.12017753
90LXR_22292898_ChIP-Seq_THP-1_Human1.11071370
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10741437
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10011291
93SMC4_20622854_ChIP-Seq_HELA_Human1.08633388
94EGR1_19032775_ChIP-ChIP_M12_Human1.08209650
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07812713
96GATA6_25053715_ChIP-Seq_YYC3_Human1.04253711
97* TP63_22573176_ChIP-Seq_HFKS_Human1.03978039
98SMRT_27268052_Chip-Seq_Bcells_Human1.03306887
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02295769
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01688914
101* RXR_22158963_ChIP-Seq_LIVER_Mouse1.01084259
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.00491053
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99838851
104* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99535652
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99271116
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98832005
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98268084
108PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97900656
109CEBPB_22108803_ChIP-Seq_LS180_Human0.96350802
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.96267771
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95639316
112BCOR_27268052_Chip-Seq_Bcells_Human0.94981792
113BCL6_27268052_Chip-Seq_Bcells_Human0.94510264
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94327251
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94017680
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93723886
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93370266
118* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93122213
119JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93093682
120* FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92564020
121GATA2_19941826_ChIP-Seq_K562_Human0.91252996
122MAF_26560356_Chip-Seq_TH1_Human0.89723832
123GATA3_27048872_Chip-Seq_THYMUS_Human0.88891273
124TP53_18474530_ChIP-ChIP_U2OS_Human0.87952547
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86769924
126SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85618803
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.85559875
128BRD4_25478319_ChIP-Seq_HGPS_Human0.84133550
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83447214
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81803479
131GATA4_25053715_ChIP-Seq_YYC3_Human0.79038559
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78345102
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78312275
134* TP63_23658742_ChIP-Seq_EP156T_Human0.75617122
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75116146
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.75062670
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.74965080
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74818181
139* LXR_22158963_ChIP-Seq_LIVER_Mouse0.73921735
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73795515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.26825549
2MP0008875_abnormal_xenobiotic_pharmacok3.57343021
3MP0003303_peritoneal_inflammation3.42141761
4MP0001835_abnormal_antigen_presentation3.40325953
5MP0009785_altered_susceptibility_to3.39894781
6MP0002419_abnormal_innate_immunity3.25094296
7MP0002148_abnormal_hypersensitivity_rea2.72756986
8MP0006082_CNS_inflammation2.63407498
9MP0005025_abnormal_response_to2.55982732
10MP0009278_abnormal_bone_marrow2.52118449
11MP0005000_abnormal_immune_tolerance2.51430132
12MP0005058_abnormal_lysosome_morphology2.48925583
13MP0003724_increased_susceptibility_to2.48437346
14MP0002653_abnormal_ependyma_morphology2.45847101
15MP0004043_abnormal_pH_regulation2.42797380
16MP0001533_abnormal_skeleton_physiology2.38527408
17MP0000569_abnormal_digit_pigmentation2.36546584
18MP0001853_heart_inflammation2.30098057
19MP0002452_abnormal_antigen_presenting2.25950059
20MP0009764_decreased_sensitivity_to2.14629099
21MP0000343_altered_response_to2.08809770
22MP0003191_abnormal_cellular_cholesterol2.06214706
23MP0003566_abnormal_cell_adhesion1.99934201
24MP0001790_abnormal_immune_system1.98414511
25MP0005387_immune_system_phenotype1.98414511
26MP0003448_altered_tumor_morphology1.97528172
27MP0005464_abnormal_platelet_physiology1.97117129
28MP0001800_abnormal_humoral_immune1.92568621
29MP0005167_abnormal_blood-brain_barrier1.92372393
30MP0002405_respiratory_system_inflammati1.90287766
31MP0002723_abnormal_immune_serum1.89657200
32MP0000858_altered_metastatic_potential1.87460638
33MP0001819_abnormal_immune_cell1.86229462
34MP0003866_abnormal_defecation1.84589548
35MP0002420_abnormal_adaptive_immunity1.83316383
36MP0001545_abnormal_hematopoietic_system1.79709614
37MP0005397_hematopoietic_system_phenotyp1.79709614
38MP0000685_abnormal_immune_system1.78010108
39MP0003279_aneurysm1.77662461
40MP0004264_abnormal_extraembryonic_tissu1.75280369
41MP0004947_skin_inflammation1.75239077
42MP0002933_joint_inflammation1.74128355
43MP0002139_abnormal_hepatobiliary_system1.71614229
44MP0001845_abnormal_inflammatory_respons1.71293080
45MP0005671_abnormal_response_to1.66409448
46MP0003172_abnormal_lysosome_physiology1.65998167
47MP0010678_abnormal_skin_adnexa1.62601684
48MP0005083_abnormal_biliary_tract1.61100170
49MP0003075_altered_response_to1.60834208
50MP0002998_abnormal_bone_remodeling1.57676646
51MP0002277_abnormal_respiratory_mucosa1.55267245
52MP0003806_abnormal_nucleotide_metabolis1.52882697
53MP0005166_decreased_susceptibility_to1.51197050
54MP0003300_gastrointestinal_ulcer1.49997190
55MP0001765_abnormal_ion_homeostasis1.49090971
56MP0010155_abnormal_intestine_physiology1.48011248
57MP0005165_increased_susceptibility_to1.46040916
58MP0003183_abnormal_peptide_metabolism1.44114074
59MP0008469_abnormal_protein_level1.40205354
60MP0003453_abnormal_keratinocyte_physiol1.37047231
61MP0005390_skeleton_phenotype1.36292130
62MP0005257_abnormal_intraocular_pressure1.33305378
63MP0004510_myositis1.32725665
64MP0004019_abnormal_vitamin_homeostasis1.29838311
65MP0005164_abnormal_response_to1.28852916
66MP0002796_impaired_skin_barrier1.28810292
67MP0003828_pulmonary_edema1.27227990
68MP0005174_abnormal_tail_pigmentation1.26598247
69MP0005365_abnormal_bile_salt1.24210991
70MP0005275_abnormal_skin_tensile1.23021505
71MP0005023_abnormal_wound_healing1.19242331
72MP0000465_gastrointestinal_hemorrhage1.17776600
73MP0000716_abnormal_immune_system1.16762993
74MP0000383_abnormal_hair_follicle1.16138278
75MP0004883_abnormal_blood_vessel1.15536984
76MP0000015_abnormal_ear_pigmentation1.14058603
77MP0005076_abnormal_cell_differentiation1.10304566
78MP0001851_eye_inflammation1.09893298
79MP0005085_abnormal_gallbladder_physiolo1.08965756
80MP0008438_abnormal_cutaneous_collagen1.07189682
81MP0005310_abnormal_salivary_gland1.04196367
82MP0003795_abnormal_bone_structure1.03224490
83MP0004808_abnormal_hematopoietic_stem1.02567421
84MP0002398_abnormal_bone_marrow1.02398986
85MP0003186_abnormal_redox_activity0.99685525
86MP0002396_abnormal_hematopoietic_system0.97606021
87MP0002254_reproductive_system_inflammat0.96359360
88MP0009333_abnormal_splenocyte_physiolog0.96020972
89MP0010307_abnormal_tumor_latency0.95515972
90MP0001873_stomach_inflammation0.95476237
91MP0000689_abnormal_spleen_morphology0.95264891
92MP0002168_other_aberrant_phenotype0.94036541
93MP0003690_abnormal_glial_cell0.93499061
94MP0008260_abnormal_autophagy0.92160644
95MP0002429_abnormal_blood_cell0.91941890
96MP0001664_abnormal_digestion0.91086844
97MP0009840_abnormal_foam_cell0.90190368
98MP0009763_increased_sensitivity_to0.88969757
99MP0005381_digestive/alimentary_phenotyp0.88368007
100MP0009765_abnormal_xenobiotic_induced0.88168950
101MP0005451_abnormal_body_composition0.87602459
102MP0006054_spinal_hemorrhage0.87440119
103MP0001984_abnormal_olfaction0.86709875
104MP0004782_abnormal_surfactant_physiolog0.86694220
105MP0005636_abnormal_mineral_homeostasis0.86535976
106MP0002136_abnormal_kidney_physiology0.86197166
107MP0003763_abnormal_thymus_physiology0.85602271
108MP0002006_tumorigenesis0.85578064
109MP0003705_abnormal_hypodermis_morpholog0.85481537
110MP0001958_emphysema0.85183945
111MP0010234_abnormal_vibrissa_follicle0.83925906
112MP0002060_abnormal_skin_morphology0.83765477
113MP0000604_amyloidosis0.83455132
114MP0002132_abnormal_respiratory_system0.82712625
115MP0009780_abnormal_chondrocyte_physiolo0.81361760
116MP0008004_abnormal_stomach_pH0.81188994
117MP0003656_abnormal_erythrocyte_physiolo0.80707150
118MP0000490_abnormal_crypts_of0.80234955
119MP0000678_abnormal_parathyroid_gland0.79944927
120MP0002722_abnormal_immune_system0.78833806
121MP0005248_abnormal_Harderian_gland0.77192834
122MP0002166_altered_tumor_susceptibility0.76839016
123MP0010352_gastrointestinal_tract_polyps0.76078820
124MP0003091_abnormal_cell_migration0.75400317
125MP0001216_abnormal_epidermal_layer0.74968105
126MP0002138_abnormal_hepatobiliary_system0.74871271
127MP0005377_hearing/vestibular/ear_phenot0.74684159
128MP0003878_abnormal_ear_physiology0.74684159
129MP0005319_abnormal_enzyme/_coenzyme0.74442467
130MP0002837_dystrophic_cardiac_calcinosis0.74237574
131MP0002098_abnormal_vibrissa_morphology0.73854938
132MP0001663_abnormal_digestive_system0.71624129
133MP0000249_abnormal_blood_vessel0.69420789

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.17060187
2Abnormal respiratory motile cilium morphology (HP:0005938)9.17060187
3Dynein arm defect of respiratory motile cilia (HP:0012255)9.01947301
4Absent/shortened dynein arms (HP:0200106)9.01947301
5Abnormal respiratory motile cilium physiology (HP:0012261)9.01090911
6Abnormal ciliary motility (HP:0012262)8.72994060
7Rhinitis (HP:0012384)8.42222311
8Chronic bronchitis (HP:0004469)7.22673378
9Recurrent abscess formation (HP:0002722)6.91810843
10Nasal polyposis (HP:0100582)6.62939731
11Bronchiectasis (HP:0002110)6.61792280
12Eczematoid dermatitis (HP:0000976)6.60399911
13Recurrent gram-negative bacterial infections (HP:0005420)6.06706074
14Recurrent bacterial skin infections (HP:0005406)5.82882920
15Abnormality of the nasal mucosa (HP:0000433)5.71941420
16Abnormality of macrophages (HP:0004311)4.99705536
17Hyperactive renin-angiotensin system (HP:0000841)4.61353512
18Orchitis (HP:0100796)4.51274611
19Myositis (HP:0100614)4.38652060
20Bronchitis (HP:0012387)4.34156779
21Recurrent sinusitis (HP:0011108)4.30378911
22Vacuolated lymphocytes (HP:0001922)4.26322935
23Increased cerebral lipofuscin (HP:0011813)4.23695684
24Retrobulbar optic neuritis (HP:0100654)4.16315538
25Optic neuritis (HP:0100653)4.16315538
26Obstructive lung disease (HP:0006536)3.95525714
27Chronic obstructive pulmonary disease (HP:0006510)3.95525714
28Gingivitis (HP:0000230)3.93980530
29Mediastinal lymphadenopathy (HP:0100721)3.85185408
30Chronic sinusitis (HP:0011109)3.84405042
31Recurrent skin infections (HP:0001581)3.68104543
32Stomatitis (HP:0010280)3.60208137
33Myocardial infarction (HP:0001658)3.55096310
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.53199512
35Recurrent otitis media (HP:0000403)3.52734373
36Chronic otitis media (HP:0000389)3.52467630
37Male infertility (HP:0003251)3.51786414
38Infertility (HP:0000789)3.47822204
39Recurrent fungal infections (HP:0002841)3.27526136
40Urticaria (HP:0001025)3.24171618
41Prostate neoplasm (HP:0100787)3.20845738
42Systemic lupus erythematosus (HP:0002725)3.05512619
43Axonal loss (HP:0003447)2.99512598
44Hepatosplenomegaly (HP:0001433)2.92187609
45Dysostosis multiplex (HP:0000943)2.91486455
46Mucopolysacchariduria (HP:0008155)2.90289915
47Urinary glycosaminoglycan excretion (HP:0003541)2.90289915
48Decreased circulating renin level (HP:0003351)2.81591320
49Abnormality of polysaccharide metabolism (HP:0011012)2.79618381
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79618381
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79618381
52Keratoconjunctivitis sicca (HP:0001097)2.76924480
53Abnormal platelet volume (HP:0011876)2.66085676
54Arterial thrombosis (HP:0004420)2.66007128
55Joint hemorrhage (HP:0005261)2.64444393
56Disinhibition (HP:0000734)2.63347198
57Chronic mucocutaneous candidiasis (HP:0002728)2.60518312
58Recurrent cutaneous fungal infections (HP:0011370)2.60518312
59Elevated erythrocyte sedimentation rate (HP:0003565)2.58868253
60Abnormality of liposaccharide metabolism (HP:0010968)2.58456653
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.58456653
62Abnormality of glycolipid metabolism (HP:0010969)2.58456653
63Periodontitis (HP:0000704)2.58307055
64Keratoconjunctivitis (HP:0001096)2.50392878
65Vasculitis (HP:0002633)2.50234258
66Recurrent pneumonia (HP:0006532)2.45894277
67Increased IgE level (HP:0003212)2.45198922
68Abnormality of renin-angiotensin system (HP:0000847)2.42493519
69Pustule (HP:0200039)2.42446307
70Cellulitis (HP:0100658)2.41106955
71Abnormality of the lumbar spine (HP:0100712)2.39453976
72Thick nail (HP:0001805)2.36861445
73Gingival bleeding (HP:0000225)2.36336639
74Meningitis (HP:0001287)2.35816397
75Recurrent bronchitis (HP:0002837)2.35801617
76Abnormality of chloride homeostasis (HP:0011422)2.31187024
77Cheilitis (HP:0100825)2.31043289
78Osteomyelitis (HP:0002754)2.30766283
79Atelectasis (HP:0100750)2.30184846
80Increased mean platelet volume (HP:0011877)2.28216302
81Hyperaldosteronism (HP:0000859)2.25965528
82Basal ganglia calcification (HP:0002135)2.25718067
83Pulmonary infiltrates (HP:0002113)2.25417255
84Prolonged bleeding time (HP:0003010)2.24747890
85Renal salt wasting (HP:0000127)2.24730174
86Hemoptysis (HP:0002105)2.22205249
87Loss of speech (HP:0002371)2.18225853
88Cervical subluxation (HP:0003308)2.17081846
89Petechiae (HP:0000967)2.13953097
90Occipital encephalocele (HP:0002085)2.13796692
91Anorexia (HP:0002039)2.07995078
92Autoimmune thrombocytopenia (HP:0001973)2.07770815
93Tetraparesis (HP:0002273)2.05974049
94Gangrene (HP:0100758)2.04726157
95Recurrent lower respiratory tract infections (HP:0002783)2.03712138
96Leukocytosis (HP:0001974)2.03556001
97Thickened calvaria (HP:0002684)2.02115345
98Abnormality of the prostate (HP:0008775)2.01314722
99Vertebral compression fractures (HP:0002953)2.00666263
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3214024
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.98206445
102Osteolytic defects of the hand bones (HP:0009699)1.98206445
103True hermaphroditism (HP:0010459)1.98195449
104Spontaneous hematomas (HP:0007420)1.97608892
105Pancreatic fibrosis (HP:0100732)1.96468396
106Bilateral sensorineural hearing impairment (HP:0008619)1.96216966
107Menorrhagia (HP:0000132)1.96192504
108Hyperkalemia (HP:0002153)1.96092180
109Epiphyseal dysplasia (HP:0002656)1.94309654
110Skin ulcer (HP:0200042)1.90952654
111Glomerulopathy (HP:0100820)1.89860939
112Tubulointerstitial nephritis (HP:0001970)1.89021521
113Epistaxis (HP:0000421)1.87460533
114Absent frontal sinuses (HP:0002688)1.86876929
115Peritonitis (HP:0002586)1.86750678
116Gastrointestinal infarctions (HP:0005244)1.86438779
117Flat acetabular roof (HP:0003180)1.85522570
118Nausea (HP:0002018)1.84712645
119Glomerulonephritis (HP:0000099)1.84706759
120Interstitial pulmonary disease (HP:0006530)1.83494452
121Thoracic kyphosis (HP:0002942)1.82719070
122Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82465110
123Encephalitis (HP:0002383)1.81272403
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81028109
125Abnormality of iron homeostasis (HP:0011031)1.80302861
126Hematochezia (HP:0002573)1.79517285
127Beaking of vertebral bodies (HP:0004568)1.78980396
128Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.75849501
129Agnosia (HP:0010524)1.75449807
130Submucous cleft hard palate (HP:0000176)1.74987528
131Albinism (HP:0001022)1.74071880
132Hyponatremia (HP:0002902)1.73239061
133Keratitis (HP:0000491)1.71684412
134Pathologic fracture (HP:0002756)1.71529141
135Nephritis (HP:0000123)1.71305608
136Abnormality of the distal phalanges of the toes (HP:0010182)1.71087573
137Cystic liver disease (HP:0006706)1.70206957
138Amyloidosis (HP:0011034)1.69079036
139Nephropathy (HP:0000112)1.57094638
140Cone-rod dystrophy (HP:0000548)1.55372128
141Pancreatic cysts (HP:0001737)1.53482796
142Malnutrition (HP:0004395)1.51722560
143Purpura (HP:0000979)1.49368374
144Ventricular fibrillation (HP:0001663)1.48019783
145Tubular atrophy (HP:0000092)1.45699020
146Abnormality of midbrain morphology (HP:0002418)1.43676158
147Molar tooth sign on MRI (HP:0002419)1.43676158
148Nephronophthisis (HP:0000090)1.40689060
149Distal lower limb muscle weakness (HP:0009053)1.34136536
150Furrowed tongue (HP:0000221)1.32718274
151Hypokalemic alkalosis (HP:0001949)1.31137049
152Chronic hepatic failure (HP:0100626)1.30042206
153Congenital hepatic fibrosis (HP:0002612)1.28893937
154Increased serum ferritin (HP:0003281)1.28151077
155Alkalosis (HP:0001948)1.26147932
156Abnormality of sodium homeostasis (HP:0010931)1.25769499
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.24482072
158Short nail (HP:0001799)1.23903364
159Abnormality of the renal medulla (HP:0100957)1.23432648
160Glucose intolerance (HP:0000833)1.22905731
161Hypotension (HP:0002615)1.22832903
162Adrenal overactivity (HP:0002717)1.21803004
163Hemorrhage of the eye (HP:0011885)1.20793781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.78882183
2EPHA25.28421484
3IRAK43.65503337
4IRAK33.40537503
5MAP3K143.04925243
6RIPK42.76649406
7TRPM72.74296403
8BLK2.67234773
9MAP3K32.34371772
10PBK2.33405307
11TBK12.31133022
12MAP3K22.27761365
13TEC2.23208812
14ERBB32.15156816
15KIT2.01732954
16ERN11.97023403
17BTK1.95593889
18TYK21.92931003
19NEK91.90532573
20TXK1.85708833
21CSK1.82430458
22IKBKB1.78227756
23EPHB11.74743294
24MAP2K31.72569439
25HCK1.71808940
26TGFBR21.69119354
27JAK31.66510438
28TAOK11.56909739
29STK101.52071848
30PIM21.49934082
31IKBKE1.49272345
32FGR1.48062852
33RPS6KA41.41856845
34GRK61.39676754
35PTK61.34283030
36TRIB31.27986897
37TAOK31.25311647
38RIPK11.24820716
39NME21.24432836
40ITK1.23956414
41JAK11.20531378
42MAPKAPK31.18250423
43PRKG21.17910676
44SMG11.16153721
45ACVR1B1.13870939
46MAP4K11.13639037
47CSF1R1.11019947
48FGFR31.10222706
49PIK3CA1.06587309
50PTK2B1.06025552
51MST41.02849243
52ZAP701.02338499
53LMTK21.01934108
54LYN1.01222966
55SIK31.00053976
56FRK0.99733015
57MARK30.98480705
58NUAK10.96907006
59MAP3K130.96896666
60TTN0.96735426
61YES10.95304285
62TNK20.93609797
63CHUK0.92470010
64SYK0.91970358
65MAP3K10.91207396
66FES0.90823894
67PAK40.90790906
68STK30.86217769
69PDPK10.85929345
70EIF2AK20.84762994
71LCK0.84602872
72EPHA30.83071480
73MAP3K120.82741632
74PIM10.81281417
75PTK20.79711251
76MST1R0.76923459
77MET0.76123399
78BMX0.76015973
79PRKCD0.74933305
80ABL20.74270778
81MARK20.74261280
82ABL10.73316581
83STK40.73015837
84LRRK20.72753141
85JAK20.71946329
86CAMK1D0.69820862
87MAP3K70.69608007
88GRK70.67146513
89CDC42BPA0.66061553
90PKN20.65724697
91CLK10.65063844
92EGFR0.65058702
93PDK10.63546674
94KSR20.63007945
95EIF2AK30.62609641
96NME10.62475703
97EPHB20.61034217
98MAP3K60.59118747
99MAPKAPK20.59111038
100PRKCQ0.58878838
101ZAK0.57770307
102CAMKK20.57483734
103NEK60.57396695
104BMPR20.56334949
105MOS0.56167883
106GRK10.54903149
107MAP2K60.54330903
108IRAK20.53363961
109TAOK20.53313132
110FGFR40.51328967
111CDK60.51219641
112ADRBK20.51105068
113MATK0.50385152
114PRPF4B0.49715288
115IRAK10.49167934
116STK240.48518465
117PIK3CG0.48226499
118MAP3K110.46330955
119IGF1R0.45684043
120FYN0.44988111
121FER0.44684287
122BMPR1B0.44563810
123PRKAA20.43827660
124ERBB40.43178775
125TESK10.42358642
126MAP3K50.41229027
127CASK0.41092608
128STK380.39786208
129PRKCH0.38668564
130SGK30.38180966
131RPS6KA60.36197758
132SGK20.35705411
133MAPK110.34606261
134CAMKK10.31946765
135PDGFRB0.30425051
136ERBB20.30225534
137HIPK20.30042212

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.52802407
2Leishmaniasis_Homo sapiens_hsa051403.40152230
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.84238690
4Phenylalanine metabolism_Homo sapiens_hsa003602.48858093
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43222553
6Osteoclast differentiation_Homo sapiens_hsa043802.39265647
7Chemical carcinogenesis_Homo sapiens_hsa052042.39181497
8Phagosome_Homo sapiens_hsa041452.37095445
9Tuberculosis_Homo sapiens_hsa051522.29280128
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.21380145
11Malaria_Homo sapiens_hsa051442.19279626
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11124081
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.10533394
14Lysosome_Homo sapiens_hsa041422.09852119
15Pertussis_Homo sapiens_hsa051332.07314281
16Rheumatoid arthritis_Homo sapiens_hsa053232.07150615
17Legionellosis_Homo sapiens_hsa051342.04337311
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99512797
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88878675
20Tyrosine metabolism_Homo sapiens_hsa003501.84644669
21Other glycan degradation_Homo sapiens_hsa005111.70356865
22Hematopoietic cell lineage_Homo sapiens_hsa046401.65366860
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.65153890
24Graft-versus-host disease_Homo sapiens_hsa053321.64746862
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64508937
26TNF signaling pathway_Homo sapiens_hsa046681.64405705
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.64009771
28Salmonella infection_Homo sapiens_hsa051321.60956776
29Shigellosis_Homo sapiens_hsa051311.59533699
30Allograft rejection_Homo sapiens_hsa053301.57711838
31Measles_Homo sapiens_hsa051621.54978921
32Complement and coagulation cascades_Homo sapiens_hsa046101.54013218
33Caffeine metabolism_Homo sapiens_hsa002321.52159988
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49787322
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49433292
36Toxoplasmosis_Homo sapiens_hsa051451.47049088
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.41598188
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39217434
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33406723
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31727415
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31033957
42Glutathione metabolism_Homo sapiens_hsa004801.27510777
43Apoptosis_Homo sapiens_hsa042101.26499927
44Influenza A_Homo sapiens_hsa051641.25378308
45B cell receptor signaling pathway_Homo sapiens_hsa046621.24616216
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22989557
47Chemokine signaling pathway_Homo sapiens_hsa040621.19868169
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17879211
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15927651
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14657785
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.14142256
52Hepatitis B_Homo sapiens_hsa051611.13752129
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13509468
54Asthma_Homo sapiens_hsa053101.12313427
55Amoebiasis_Homo sapiens_hsa051461.11857819
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03804564
57Sulfur metabolism_Homo sapiens_hsa009201.02250717
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93565674
59Histidine metabolism_Homo sapiens_hsa003400.90712585
60African trypanosomiasis_Homo sapiens_hsa051430.89863550
61Hepatitis C_Homo sapiens_hsa051600.88331993
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87936147
63Antigen processing and presentation_Homo sapiens_hsa046120.87831560
64Sphingolipid metabolism_Homo sapiens_hsa006000.87577921
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86694199
66Viral myocarditis_Homo sapiens_hsa054160.86299864
67Arachidonic acid metabolism_Homo sapiens_hsa005900.85614762
68Nitrogen metabolism_Homo sapiens_hsa009100.84298516
69Type I diabetes mellitus_Homo sapiens_hsa049400.84103049
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.83423110
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82643479
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.82087783
73* Retinol metabolism_Homo sapiens_hsa008300.81415421
74Herpes simplex infection_Homo sapiens_hsa051680.80920209
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80032056
76Pancreatic cancer_Homo sapiens_hsa052120.79458818
77Acute myeloid leukemia_Homo sapiens_hsa052210.78432206
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76663555
79Platelet activation_Homo sapiens_hsa046110.76433496
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76200538
81Fatty acid degradation_Homo sapiens_hsa000710.74861084
82Collecting duct acid secretion_Homo sapiens_hsa049660.74170036
83Autoimmune thyroid disease_Homo sapiens_hsa053200.73378577
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71135244
85Starch and sucrose metabolism_Homo sapiens_hsa005000.71088298
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71072679
87Proteoglycans in cancer_Homo sapiens_hsa052050.70638608
88Linoleic acid metabolism_Homo sapiens_hsa005910.69456702
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63504930
90Chronic myeloid leukemia_Homo sapiens_hsa052200.62247682
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59923170
92Pancreatic secretion_Homo sapiens_hsa049720.59737394
93Bladder cancer_Homo sapiens_hsa052190.58434351
94Steroid biosynthesis_Homo sapiens_hsa001000.57281080
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55653545
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.54541512
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53873979
98Focal adhesion_Homo sapiens_hsa045100.53756037
99ECM-receptor interaction_Homo sapiens_hsa045120.52521429
100Adherens junction_Homo sapiens_hsa045200.52052825
101T cell receptor signaling pathway_Homo sapiens_hsa046600.51688639
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50923044
103Primary immunodeficiency_Homo sapiens_hsa053400.50639930
104Melanoma_Homo sapiens_hsa052180.48380607
105ABC transporters_Homo sapiens_hsa020100.48210552
106Small cell lung cancer_Homo sapiens_hsa052220.47433337
107Prolactin signaling pathway_Homo sapiens_hsa049170.46844092
108HIF-1 signaling pathway_Homo sapiens_hsa040660.45323257
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.45122828
110Notch signaling pathway_Homo sapiens_hsa043300.44587666
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.44050136
112Mineral absorption_Homo sapiens_hsa049780.43639205
113Choline metabolism in cancer_Homo sapiens_hsa052310.43227413
114p53 signaling pathway_Homo sapiens_hsa041150.40270537
115PPAR signaling pathway_Homo sapiens_hsa033200.40199388
116Endocytosis_Homo sapiens_hsa041440.39595543
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38140320
118Tight junction_Homo sapiens_hsa045300.37207719
119MicroRNAs in cancer_Homo sapiens_hsa052060.34901979
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34691255
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.33773370
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32488280
123FoxO signaling pathway_Homo sapiens_hsa040680.32306104
124Viral carcinogenesis_Homo sapiens_hsa052030.31142406
125Insulin resistance_Homo sapiens_hsa049310.28619416
126Prostate cancer_Homo sapiens_hsa052150.26323188
127beta-Alanine metabolism_Homo sapiens_hsa004100.26313992

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