DHRS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1complement activation, alternative pathway (GO:0006957)4.85021096
2negative regulation of lipase activity (GO:0060192)4.41179955
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.27839714
4primary alcohol catabolic process (GO:0034310)4.22906506
5ethanol oxidation (GO:0006069)4.17191818
6regulation of protein activation cascade (GO:2000257)4.11564377
7regulation of cholesterol esterification (GO:0010872)4.08130951
8regulation of complement activation (GO:0030449)4.07223288
9protein carboxylation (GO:0018214)3.99646828
10peptidyl-glutamic acid carboxylation (GO:0017187)3.99646828
11low-density lipoprotein particle remodeling (GO:0034374)3.86347387
12protein-lipid complex assembly (GO:0065005)3.83372283
13high-density lipoprotein particle remodeling (GO:0034375)3.80166359
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79812802
15L-phenylalanine catabolic process (GO:0006559)3.79812802
16indole-containing compound catabolic process (GO:0042436)3.78937728
17indolalkylamine catabolic process (GO:0046218)3.78937728
18tryptophan catabolic process (GO:0006569)3.78937728
19aromatic amino acid family catabolic process (GO:0009074)3.77515242
20ethanol metabolic process (GO:0006067)3.75353743
21phospholipid efflux (GO:0033700)3.72373450
22negative regulation of cholesterol transport (GO:0032375)3.67607387
23negative regulation of sterol transport (GO:0032372)3.67607387
24positive regulation of extracellular matrix organization (GO:1903055)3.66694958
25reverse cholesterol transport (GO:0043691)3.65257601
26tryptophan metabolic process (GO:0006568)3.64933820
27very-low-density lipoprotein particle assembly (GO:0034379)3.63845220
28cellular glucuronidation (GO:0052695)3.59571997
29diterpenoid biosynthetic process (GO:0016102)3.55097487
30uronic acid metabolic process (GO:0006063)3.53607694
31glucuronate metabolic process (GO:0019585)3.53607694
32L-phenylalanine metabolic process (GO:0006558)3.53251852
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.53251852
34drug catabolic process (GO:0042737)3.51115220
35glyoxylate metabolic process (GO:0046487)3.51046909
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50925602
37epoxygenase P450 pathway (GO:0019373)3.50011452
38bile acid biosynthetic process (GO:0006699)3.49531071
39retinal metabolic process (GO:0042574)3.48859382
40complement activation (GO:0006956)3.46895334
41alpha-linolenic acid metabolic process (GO:0036109)3.46856920
42homocysteine metabolic process (GO:0050667)3.40502982
43regulation of interferon-beta biosynthetic process (GO:0045357)3.40185065
44regulation of metalloenzyme activity (GO:0048552)3.39565095
45protein-lipid complex remodeling (GO:0034368)3.35351435
46macromolecular complex remodeling (GO:0034367)3.35351435
47plasma lipoprotein particle remodeling (GO:0034369)3.35351435
48sulfur amino acid catabolic process (GO:0000098)3.33271546
49positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.32344758
50negative regulation of coagulation (GO:0050819)3.30837924
51exogenous drug catabolic process (GO:0042738)3.29900234
52daunorubicin metabolic process (GO:0044597)3.28666992
53polyketide metabolic process (GO:0030638)3.28666992
54doxorubicin metabolic process (GO:0044598)3.28666992
55negative regulation of blood coagulation (GO:0030195)3.25313180
56negative regulation of hemostasis (GO:1900047)3.25313180
57regulation of cytokine secretion involved in immune response (GO:0002739)3.25240519
58kynurenine metabolic process (GO:0070189)3.24675241
59L-ascorbic acid metabolic process (GO:0019852)3.23155983
60plasma lipoprotein particle clearance (GO:0034381)3.21600005
61* primary alcohol metabolic process (GO:0034308)3.20632627
62phospholipid homeostasis (GO:0055091)3.20390222
63glutathione derivative biosynthetic process (GO:1901687)3.16380485
64glutathione derivative metabolic process (GO:1901685)3.16380485
65protein-lipid complex subunit organization (GO:0071825)3.14046742
66negative regulation of wound healing (GO:0061045)3.13114314
67complement activation, classical pathway (GO:0006958)3.13037913
68drug metabolic process (GO:0017144)3.11388232
69regulation of cholesterol transport (GO:0032374)3.11311953
70regulation of sterol transport (GO:0032371)3.11311953
71protein activation cascade (GO:0072376)3.09339559
72regulation of plasminogen activation (GO:0010755)3.08606337
73cholesterol efflux (GO:0033344)3.07859914
74regulation of integrin-mediated signaling pathway (GO:2001044)3.06068829
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04898005
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.04898005
77modulation by symbiont of host immune response (GO:0052553)3.04898005
78positive regulation by symbiont of host defense response (GO:0052509)3.04898005
79modulation by symbiont of host defense response (GO:0052031)3.04898005
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04898005
81cholesterol homeostasis (GO:0042632)3.04873029
82regulation of fibrinolysis (GO:0051917)3.03652721
83regulation of heterotypic cell-cell adhesion (GO:0034114)3.01373572
84negative regulation of complement activation (GO:0045916)2.98857143
85positive regulation of blood coagulation (GO:0030194)2.98343931
86positive regulation of hemostasis (GO:1900048)2.98343931
87regulation of cholesterol storage (GO:0010885)2.97018113
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.97010065
89sterol homeostasis (GO:0055092)2.96862799
90fibrinolysis (GO:0042730)2.96198238
91regulation of triglyceride catabolic process (GO:0010896)2.94570774
92urea metabolic process (GO:0019627)2.94465120
93urea cycle (GO:0000050)2.94465120
94cobalamin metabolic process (GO:0009235)2.93850821
95progesterone metabolic process (GO:0042448)2.92963937
96positive regulation of interferon-alpha production (GO:0032727)2.91972150
97opsonization (GO:0008228)2.91759969
98amino-acid betaine metabolic process (GO:0006577)2.90874947
99negative regulation of fibrinolysis (GO:0051918)2.89664237
100retinoic acid metabolic process (GO:0042573)2.89373899
101aminoglycoside antibiotic metabolic process (GO:0030647)2.88887840
102positive regulation of coagulation (GO:0050820)2.88780780
103positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.87904292
104amine catabolic process (GO:0009310)2.87579751
105cellular biogenic amine catabolic process (GO:0042402)2.87579751
106pinocytosis (GO:0006907)2.87440372
107positive regulation of smooth muscle cell migration (GO:0014911)2.87152614
108cholesterol transport (GO:0030301)2.86499144
109sterol transport (GO:0015918)2.86499144
110production of molecular mediator involved in inflammatory response (GO:0002532)2.86390344
111negative regulation of humoral immune response (GO:0002921)2.86220028
112* retinoid metabolic process (GO:0001523)2.85672076
113positive regulation of cholesterol transport (GO:0032376)2.85458139
114positive regulation of sterol transport (GO:0032373)2.85458139
115positive regulation of cholesterol efflux (GO:0010875)2.85419043
116cysteine metabolic process (GO:0006534)2.84746841
117bile acid metabolic process (GO:0008206)2.81417086
118* retinol metabolic process (GO:0042572)2.80982849
119acute-phase response (GO:0006953)2.79871627
120detection of molecule of bacterial origin (GO:0032490)2.79613880
121blood coagulation, intrinsic pathway (GO:0007597)2.77407737
122positive regulation of cellular amide metabolic process (GO:0034250)2.77126729
123cellular response to zinc ion (GO:0071294)2.76656867
124phenylpropanoid metabolic process (GO:0009698)2.76034886
125regulation of cholesterol biosynthetic process (GO:0045540)2.75808088
126negative regulation of protein activation cascade (GO:2000258)2.75600957
127acylglycerol catabolic process (GO:0046464)2.74511675
128neutral lipid catabolic process (GO:0046461)2.74511675
129regulation of interferon-alpha production (GO:0032647)2.73918610
130positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73180963
131plasma lipoprotein particle organization (GO:0071827)2.72474735
132cellular response to cadmium ion (GO:0071276)2.71730727
133microglial cell activation (GO:0001774)2.71718855
134* diterpenoid metabolic process (GO:0016101)2.71261893
135valine metabolic process (GO:0006573)2.70635820
136transcytosis (GO:0045056)2.70316258
137axonemal dynein complex assembly (GO:0070286)2.69699844
138aldehyde catabolic process (GO:0046185)2.69495214
139triglyceride homeostasis (GO:0070328)2.66299545
140acylglycerol homeostasis (GO:0055090)2.66299545
141plasma lipoprotein particle assembly (GO:0034377)2.63944624
142amyloid precursor protein catabolic process (GO:0042987)2.63877151
143lipoprotein metabolic process (GO:0042157)2.63181339
144xenobiotic catabolic process (GO:0042178)2.62999547
145nitrogen cycle metabolic process (GO:0071941)2.62331878
146regulation of cholesterol metabolic process (GO:0090181)2.62180246
147pyridine nucleotide biosynthetic process (GO:0019363)2.61832703
148nicotinamide nucleotide biosynthetic process (GO:0019359)2.61832703
149neutrophil activation involved in immune response (GO:0002283)2.61069145
150fatty acid beta-oxidation (GO:0006635)2.59439485
151positive regulation of fatty acid oxidation (GO:0046321)2.58989858
152NAD biosynthetic process (GO:0009435)2.58826257
153keratan sulfate catabolic process (GO:0042340)2.58685986
154indolalkylamine metabolic process (GO:0006586)2.58679567
155aromatic amino acid family metabolic process (GO:0009072)2.56577649
156positive regulation of triglyceride lipase activity (GO:0061365)2.55525512
157positive regulation of lipoprotein lipase activity (GO:0051006)2.55525512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.38930568
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.51991425
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.81532091
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.05497478
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.02942649
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.96112815
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.83594429
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40043547
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.29481581
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.89851863
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.76144330
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.75424189
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69342059
14* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61818604
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.59529872
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49803791
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46425960
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.43383382
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.35981114
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25460529
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15325602
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10479521
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08359912
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.04079106
25* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95426847
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92549991
27GATA1_22025678_ChIP-Seq_K562_Human1.90836856
28* CLOCK_20551151_ChIP-Seq_293T_Human1.90491706
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82896439
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77236952
31* ESR1_21235772_ChIP-Seq_MCF-7_Human1.76994932
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73452303
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.67564573
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66145387
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58564229
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53320715
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52097899
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.49488582
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.46721655
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.46721655
41* GATA6_25053715_ChIP-Seq_YYC3_Human1.46250039
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42195354
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41485773
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40755558
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39151889
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39068262
47VDR_24787735_ChIP-Seq_THP-1_Human1.38624597
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.38121890
49CJUN_26792858_Chip-Seq_BT549_Human1.37071687
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33066781
51SCL_19346495_ChIP-Seq_HPC-7_Human1.30995183
52* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30913007
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29494000
54* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27812339
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24687194
56* SOX2_20726797_ChIP-Seq_SW620_Human1.24245714
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23708406
58* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19094635
59* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18909004
60* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17729441
61* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15726527
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14243356
63* ESR2_21235772_ChIP-Seq_MCF-7_Human1.13724328
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12065674
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11896171
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11835967
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11802829
68* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11260009
69* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11235929
70GATA3_24758297_ChIP-Seq_MCF-7_Human1.10021736
71EGR1_19032775_ChIP-ChIP_M12_Human1.09844722
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09770214
73* CDX2_20551321_ChIP-Seq_CACO-2_Human1.09525301
74* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09471695
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.07999636
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06979368
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05473760
78RUNX_20019798_ChIP-Seq_JUKART_Human1.04684545
79ZNF263_19887448_ChIP-Seq_K562_Human1.02194411
80TP53_16413492_ChIP-PET_HCT116_Human1.01640855
81PU_27001747_Chip-Seq_BMDM_Mouse1.01619807
82STAT1_20625510_ChIP-Seq_HELA_Human0.99558456
83* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98166053
84* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96393300
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95936142
86* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94208480
87TP63_23658742_ChIP-Seq_EP156T_Human0.93634116
88* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93250779
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92446225
90* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91969612
91BRD4_25478319_ChIP-Seq_HGPS_Human0.90135807
92* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89563721
93* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89557978
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89229064
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88793441
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.88337369
97STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88218181
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87711973
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87652516
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87241932
101* GATA2_19941826_ChIP-Seq_K562_Human0.87198618
102AHR_22903824_ChIP-Seq_MCF-7_Human0.86768804
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.85691781
104* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84416783
105* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84030874
106* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84030874
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.82922072
108GATA1_19941826_ChIP-Seq_K562_Human0.81723850
109* HNFA_21074721_ChIP-Seq_CACO-2_Human0.81661311
110* GATA4_25053715_ChIP-Seq_YYC3_Human0.81014757
111* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81014206
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80999270
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80943610
114* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80746997
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80700330
116* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80591792
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80109892
118* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80052799
119JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79763039
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79738796
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79507999
122* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78500749
123CDX2_22108803_ChIP-Seq_LS180_Human0.78343563
124* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78049154
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76287088
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.74878747
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.74878747
128* RACK7_27058665_Chip-Seq_MCF-7_Human0.74753465
129* TCF4_18268006_ChIP-ChIP_LS174T_Human0.74347238
130* PHF8_20622853_ChIP-Seq_HELA_Human0.73792128
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73173293
132VDR_24763502_ChIP-Seq_THP-1_Human0.71825889
133* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71471218
134* TP53_18474530_ChIP-ChIP_U2OS_Human0.69771270
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.69418324
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69263599
137* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69118025

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.48926310
2MP0008438_abnormal_cutaneous_collagen4.36181505
3MP0002139_abnormal_hepatobiliary_system3.92004199
4MP0003191_abnormal_cellular_cholesterol3.39793820
5MP0005365_abnormal_bile_salt3.06687204
6MP0005085_abnormal_gallbladder_physiolo3.03153134
7MP0009840_abnormal_foam_cell2.89207136
8MP0005275_abnormal_skin_tensile2.77569235
9MP0008875_abnormal_xenobiotic_pharmacok2.61912909
10MP0005058_abnormal_lysosome_morphology2.59345848
11MP0001835_abnormal_antigen_presentation2.54732515
12MP0009780_abnormal_chondrocyte_physiolo2.39346781
13MP0003724_increased_susceptibility_to2.35638962
14MP0010368_abnormal_lymphatic_system2.35009576
15MP0003252_abnormal_bile_duct2.32839950
16MP0010329_abnormal_lipoprotein_level2.21792210
17MP0005503_abnormal_tendon_morphology2.21645414
18MP0004272_abnormal_basement_membrane2.18113595
19MP0003436_decreased_susceptibility_to2.06545276
20MP0003705_abnormal_hypodermis_morpholog1.90710663
21MP0003690_abnormal_glial_cell1.86386837
22MP0003195_calcinosis1.77536889
23MP0005332_abnormal_amino_acid1.76902175
24MP0002148_abnormal_hypersensitivity_rea1.75794709
25MP0002419_abnormal_innate_immunity1.75631336
26MP0002138_abnormal_hepatobiliary_system1.70356532
27MP0004883_abnormal_blood_vessel1.70246222
28MP0009764_decreased_sensitivity_to1.70234631
29MP0004782_abnormal_surfactant_physiolog1.63551517
30MP0003075_altered_response_to1.62715507
31MP0003279_aneurysm1.56713435
32MP0004019_abnormal_vitamin_homeostasis1.56355174
33MP0003950_abnormal_plasma_membrane1.55971955
34MP0009785_altered_susceptibility_to1.50329627
35MP0002254_reproductive_system_inflammat1.48067558
36MP0003011_delayed_dark_adaptation1.46533617
37MP0001533_abnormal_skeleton_physiology1.45659710
38MP0000343_altered_response_to1.44218656
39MP0001853_heart_inflammation1.43501831
40MP0005083_abnormal_biliary_tract1.42787155
41MP0005670_abnormal_white_adipose1.41012767
42MP0000609_abnormal_liver_physiology1.37136642
43MP0001542_abnormal_bone_strength1.36524384
44MP0001958_emphysema1.34460198
45MP0003186_abnormal_redox_activity1.31662211
46MP0002060_abnormal_skin_morphology1.31498768
47MP0005464_abnormal_platelet_physiology1.30722600
48MP0003806_abnormal_nucleotide_metabolis1.28285716
49MP0005164_abnormal_response_to1.27360223
50MP0002118_abnormal_lipid_homeostasis1.27223275
51MP0003868_abnormal_feces_composition1.27075781
52MP0005319_abnormal_enzyme/_coenzyme1.26765668
53MP0005025_abnormal_response_to1.25125032
54MP0001764_abnormal_homeostasis1.24609132
55MP0008469_abnormal_protein_level1.23938878
56MP0000681_abnormal_thyroid_gland1.23030188
57MP0005023_abnormal_wound_healing1.21212455
58MP0001661_extended_life_span1.20773145
59MP0006082_CNS_inflammation1.20749233
60MP0005387_immune_system_phenotype1.19882026
61MP0001790_abnormal_immune_system1.19882026
62MP0003828_pulmonary_edema1.16859475
63MP0005166_decreased_susceptibility_to1.11746619
64MP0000604_amyloidosis1.10393963
65MP0005000_abnormal_immune_tolerance1.10148294
66MP0009643_abnormal_urine_homeostasis1.07427296
67MP0010386_abnormal_urinary_bladder1.05883587
68MP0009763_increased_sensitivity_to1.05751343
69MP0001666_abnormal_nutrient_absorption1.04592531
70MP0001845_abnormal_inflammatory_respons1.02771812
71MP0000538_abnormal_urinary_bladder1.01507564
72MP0003656_abnormal_erythrocyte_physiolo1.01199308
73MP0003566_abnormal_cell_adhesion1.01124615
74MP0002108_abnormal_muscle_morphology1.00395023
75MP0000685_abnormal_immune_system1.00101305
76MP0005584_abnormal_enzyme/coenzyme_acti0.99387748
77MP0000249_abnormal_blood_vessel0.99335809
78MP0002132_abnormal_respiratory_system0.98739295
79MP0002452_abnormal_antigen_presenting0.98257320
80MP0005508_abnormal_skeleton_morphology0.96737307
81MP0001879_abnormal_lymphatic_vessel0.96363989
82MP0002998_abnormal_bone_remodeling0.94592451
83MP0005390_skeleton_phenotype0.94307426
84MP0002405_respiratory_system_inflammati0.93107262
85MP0003448_altered_tumor_morphology0.90175591
86MP0002295_abnormal_pulmonary_circulatio0.88867460
87MP0001800_abnormal_humoral_immune0.88278059
88MP0008775_abnormal_heart_ventricle0.88062661
89MP0003300_gastrointestinal_ulcer0.86543259
90MP0006036_abnormal_mitochondrial_physio0.86401357
91MP0005636_abnormal_mineral_homeostasis0.86292645
92MP0010155_abnormal_intestine_physiology0.85663715
93MP0002136_abnormal_kidney_physiology0.85019107
94MP0002166_altered_tumor_susceptibility0.84726049
95MP0001243_abnormal_dermal_layer0.84718118
96MP0006138_congestive_heart_failure0.84630225
97MP0005595_abnormal_vascular_smooth0.83955424
98MP0005257_abnormal_intraocular_pressure0.82958819
99MP0000767_abnormal_smooth_muscle0.82050300
100MP0003879_abnormal_hair_cell0.81054235
101MP0000858_altered_metastatic_potential0.81018592
102MP0005666_abnormal_adipose_tissue0.79408259
103MP0002723_abnormal_immune_serum0.79110635
104MP0002282_abnormal_trachea_morphology0.78589515
105MP0000598_abnormal_liver_morphology0.78278813
106MP0002971_abnormal_brown_adipose0.76038209
107MP0008004_abnormal_stomach_pH0.75721266
108MP0002876_abnormal_thyroid_physiology0.75687555
109MP0006054_spinal_hemorrhage0.75370829
110MP0009115_abnormal_fat_cell0.75189452
111MP0002168_other_aberrant_phenotype0.74609317
112MP0000465_gastrointestinal_hemorrhage0.74472552
113MP0009697_abnormal_copulation0.74183309
114MP0004130_abnormal_muscle_cell0.72364021
115MP0008872_abnormal_physiological_respon0.72352129
116MP0005377_hearing/vestibular/ear_phenot0.71567243
117MP0003878_abnormal_ear_physiology0.71567243
118MP0003172_abnormal_lysosome_physiology0.71259252
119MP0005376_homeostasis/metabolism_phenot0.70129622
120MP0001756_abnormal_urination0.69523816
121MP0005167_abnormal_blood-brain_barrier0.69380236
122MP0001881_abnormal_mammary_gland0.69316140
123MP0004947_skin_inflammation0.68128922
124MP0008260_abnormal_autophagy0.67842901
125MP0005334_abnormal_fat_pad0.67670257
126MP0005165_increased_susceptibility_to0.67580973
127MP0000467_abnormal_esophagus_morphology0.66845746
128MP0004084_abnormal_cardiac_muscle0.65575214
129MP0002135_abnormal_kidney_morphology0.63708727
130MP0010352_gastrointestinal_tract_polyps0.63670921
131MP0001851_eye_inflammation0.61743996
132MP0004036_abnormal_muscle_relaxation0.61599942
133MP0000613_abnormal_salivary_gland0.61538727
134MP0003638_abnormal_response/metabolism_0.59171223
135MP0002933_joint_inflammation0.59068321

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.31782426
2Complement deficiency (HP:0004431)6.30528629
3Glomerulonephritis (HP:0000099)5.48594728
4Abnormality of complement system (HP:0005339)5.44617875
5Vacuolated lymphocytes (HP:0001922)4.48124619
6Joint hemorrhage (HP:0005261)4.10119249
7Xanthomatosis (HP:0000991)3.94599427
8Deep venous thrombosis (HP:0002625)3.87936344
9Recurrent gram-negative bacterial infections (HP:0005420)3.61973568
10Eczematoid dermatitis (HP:0000976)3.60582292
11Intrahepatic cholestasis (HP:0001406)3.58063790
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.56912021
13Nephritis (HP:0000123)3.52469550
14Prolonged partial thromboplastin time (HP:0003645)3.52310087
15Rhinitis (HP:0012384)3.51766633
16Myocardial infarction (HP:0001658)3.51182242
17Recurrent bacterial skin infections (HP:0005406)3.47578895
18Recurrent abscess formation (HP:0002722)3.47018120
19Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37180515
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.35116798
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.23577001
22Spontaneous abortion (HP:0005268)3.23497103
23Hyperlipoproteinemia (HP:0010980)3.16743188
24Protrusio acetabuli (HP:0003179)3.16726217
25Increased cerebral lipofuscin (HP:0011813)3.15660526
26Petechiae (HP:0000967)3.13983005
27Abnormality of proline metabolism (HP:0010907)3.12787812
28Hydroxyprolinuria (HP:0003080)3.12787812
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09362656
30Cervical subluxation (HP:0003308)3.04588551
31Axonal loss (HP:0003447)2.99130379
32Vascular tortuosity (HP:0004948)2.97832906
33Hypercholesterolemia (HP:0003124)2.95800638
34Abnormality of the common coagulation pathway (HP:0010990)2.91760650
35Menorrhagia (HP:0000132)2.88492607
36Abnormality of fatty-acid metabolism (HP:0004359)2.84649146
37Hypoalphalipoproteinemia (HP:0003233)2.80025555
38Hyperglycinuria (HP:0003108)2.76844528
39Generalized aminoaciduria (HP:0002909)2.75202900
40Arterial tortuosity (HP:0005116)2.67385295
41Chronic bronchitis (HP:0004469)2.64775770
42Abnormal respiratory motile cilium physiology (HP:0012261)2.62659201
43Abnormal respiratory epithelium morphology (HP:0012253)2.58014046
44Abnormal respiratory motile cilium morphology (HP:0005938)2.58014046
45Male infertility (HP:0003251)2.57712693
46Dysostosis multiplex (HP:0000943)2.56427362
47Aortic dissection (HP:0002647)2.56240034
48Fat malabsorption (HP:0002630)2.56118425
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.55677930
50Mitral stenosis (HP:0001718)2.54129689
51Osteolytic defects of the hand bones (HP:0009699)2.47800416
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.47800416
53Mucopolysacchariduria (HP:0008155)2.46146334
54Urinary glycosaminoglycan excretion (HP:0003541)2.46146334
55Spontaneous hematomas (HP:0007420)2.46121721
56Epidermoid cyst (HP:0200040)2.46055045
57Aortic aneurysm (HP:0004942)2.46044077
58Spondylolisthesis (HP:0003302)2.44049126
59Hyperammonemia (HP:0001987)2.43415654
60Hypolipoproteinemia (HP:0010981)2.43369797
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.42633546
62Abnormality of carpal bone ossification (HP:0006257)2.40964059
63Steatorrhea (HP:0002570)2.34473476
64Hypobetalipoproteinemia (HP:0003563)2.34044463
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.32968800
66Absent/shortened dynein arms (HP:0200106)2.32968800
67Atelectasis (HP:0100750)2.32817608
68Abnormality of the intrinsic pathway (HP:0010989)2.32122387
69Abnormality of macrophages (HP:0004311)2.32100368
70Abnormality of serine family amino acid metabolism (HP:0010894)2.27839424
71Abnormality of glycine metabolism (HP:0010895)2.27839424
72Abnormal ciliary motility (HP:0012262)2.26598038
73Periodontitis (HP:0000704)2.26564497
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26206066
75Abnormality of polysaccharide metabolism (HP:0011012)2.26206066
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26206066
77Gingival bleeding (HP:0000225)2.25535501
78Pustule (HP:0200039)2.25303551
79Abnormal gallbladder physiology (HP:0012438)2.24101114
80Cholecystitis (HP:0001082)2.24101114
81Cardiovascular calcification (HP:0011915)2.23110303
82Esophageal varix (HP:0002040)2.21879113
83Pigmentary retinal degeneration (HP:0001146)2.20081613
84Malnutrition (HP:0004395)2.17711581
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17502124
86Bronchiectasis (HP:0002110)2.15861822
87Progressive visual loss (HP:0000529)2.14251727
88Hepatocellular carcinoma (HP:0001402)2.14090432
89Abnormality of methionine metabolism (HP:0010901)2.12828065
90Abnormality of purine metabolism (HP:0004352)2.12710382
91Vascular calcification (HP:0004934)2.12602525
92Hypoglycemic coma (HP:0001325)2.11751795
93Follicular hyperkeratosis (HP:0007502)2.09523617
94Thick nail (HP:0001805)2.08756100
95Prolonged bleeding time (HP:0003010)2.07836667
96Epistaxis (HP:0000421)2.04722766
97Alopecia of scalp (HP:0002293)2.04574099
98Ileus (HP:0002595)2.04537712
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04495242
100Abnormality of nucleobase metabolism (HP:0010932)2.04364875
101Hyperglycinemia (HP:0002154)2.02667235
102Gingivitis (HP:0000230)2.01454859
103Conjugated hyperbilirubinemia (HP:0002908)1.99754323
104Subcapsular cataract (HP:0000523)1.99693977
105Myositis (HP:0100614)1.98528624
106Hyperactive renin-angiotensin system (HP:0000841)1.98038167
107Hepatosplenomegaly (HP:0001433)1.97076813
108Abnormal delivery (HP:0001787)1.93548940
109Pancreatitis (HP:0001733)1.92863944
110Ketosis (HP:0001946)1.92408223
111Nausea (HP:0002018)1.91870069
112Orchitis (HP:0100796)1.90846784
113Neoplasm of head and neck (HP:0012288)1.90668373
114Esophageal neoplasm (HP:0100751)1.90668373
115Hematochezia (HP:0002573)1.89278991
116Abnormality of pyrimidine metabolism (HP:0004353)1.87673861
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87161410
118Increased mean platelet volume (HP:0011877)1.86311910
119Recurrent skin infections (HP:0001581)1.85556280
120Pathologic fracture (HP:0002756)1.85521368
121Amyloidosis (HP:0011034)1.85404600
122Interstitial pulmonary disease (HP:0006530)1.84438580
123Cerebral palsy (HP:0100021)1.84002909
124Hemorrhage of the eye (HP:0011885)1.83071132
125Premature rupture of membranes (HP:0001788)1.83021295
126Abnormality of the nasal mucosa (HP:0000433)1.82672413
127Increased serum ferritin (HP:0003281)1.82340975
128Bone cyst (HP:0012062)1.82276866
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81643584
130Dicarboxylic aciduria (HP:0003215)1.81643584
131Upper motor neuron abnormality (HP:0002127)1.80586837
132Joint swelling (HP:0001386)1.80569313
133Hypertriglyceridemia (HP:0002155)1.80343536
134Purpura (HP:0000979)1.79362761
135Delayed CNS myelination (HP:0002188)1.78994133
136Thrombophlebitis (HP:0004418)1.78969663
137Alveolar cell carcinoma (HP:0006519)1.78761799
138Vertebral compression fractures (HP:0002953)1.77962721
139Nasal polyposis (HP:0100582)1.76182105
140Abnormality of transition element cation homeostasis (HP:0011030)1.74518868
141Occipital encephalocele (HP:0002085)1.73468849
142Atrophic scars (HP:0001075)1.73345660
143Stridor (HP:0010307)1.72472851
144Gout (HP:0001997)1.71930354
145Glucose intolerance (HP:0000833)1.71718822
146Soft skin (HP:0000977)1.70703823
147Exocrine pancreatic insufficiency (HP:0001738)1.68499329
148Abnormal glucose tolerance (HP:0001952)1.68372944
149Skin nodule (HP:0200036)1.68323164
150Impaired platelet aggregation (HP:0003540)1.67455605
151Abnormal platelet function (HP:0011869)1.67455605
152Abnormal hand bone ossification (HP:0010660)1.66873237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.75057593
2TGFBR23.41199011
3MAP3K143.41054212
4EPHA23.12191942
5ERN13.09068947
6BCKDK2.77172576
7TYK22.64105657
8NEK92.62578224
9IRAK42.37172731
10MAP3K122.29229890
11SIK32.27266444
12DDR22.20008683
13KIT2.16417087
14IRAK32.14628101
15MET2.11703546
16BMPR21.97112567
17TBK11.96734492
18FGFR41.91846255
19PIM21.84760388
20GRK71.80294965
21MAP4K21.80121926
22IKBKE1.76917789
23BLK1.75039862
24JAK11.72457837
25NLK1.71767578
26MAPKAPK31.65651556
27EPHB11.65083600
28IKBKB1.63841541
29TIE11.58940129
30BCR1.53288090
31MAP3K31.48953412
32TRIM281.46189501
33TEC1.43052251
34TRPM71.42552079
35TAOK31.41691691
36FRK1.40597126
37EPHA31.40192841
38PTK21.39503857
39SIK11.33990804
40BTK1.32687286
41TXK1.31969026
42TESK11.30623073
43CDK81.30510071
44STK241.28242429
45STK38L1.28229413
46AKT31.27701368
47MST1R1.27594176
48CHUK1.25633710
49TGFBR11.23679043
50FLT31.17289818
51ZAP701.16709363
52ERBB31.15774663
53MAP2K31.15048784
54EIF2AK21.14015772
55BMPR1B1.13884100
56PIK3CG1.13794620
57EPHB21.13320698
58MYLK1.11491046
59MAP4K11.07169961
60TAOK21.06885937
61JAK21.04507540
62ADRBK20.99448160
63MAP3K20.99092835
64CDK60.98538118
65ILK0.97300739
66RIPK10.97077406
67CSF1R0.96739264
68MUSK0.95251806
69PINK10.94457994
70INSRR0.94333148
71CAMK1D0.93050406
72FGFR30.92147139
73NUAK10.90517869
74PIK3CA0.90001859
75STK390.89274948
76HCK0.89060039
77ZAK0.86792636
78ACVR1B0.86350991
79SGK20.85300752
80TNIK0.83446745
81SGK30.83327575
82PDK20.82702224
83STK160.81880138
84BMX0.77864430
85LYN0.76680280
86ABL20.75798106
87YES10.74110146
88STK100.73669578
89NME10.72332170
90MAPK70.72300448
91GRK50.71744389
92LATS10.70584946
93PTK2B0.70397710
94PIM10.69718572
95PTK60.68372137
96TRIB30.68296255
97MAPK110.68205262
98PRKG20.67524108
99PAK30.65815882
100CDK90.64111439
101CSK0.64005839
102ROCK10.62679220
103ITK0.62202615
104STK30.61814423
105GRK10.61531072
106IGF1R0.61421282
107EIF2AK10.61090227
108ADRBK10.61008280
109MAP3K70.60670334
110KDR0.59487311
111PDGFRB0.59349510
112SYK0.59323771
113EIF2AK30.59231637
114LMTK20.58857474
115GRK60.58318703
116NEK60.58139783
117PAK20.56601088
118IRAK10.55930694
119ABL10.55710659
120MAP2K20.55144749
121MAP2K10.54121113
122PKN20.53730705
123PRKCD0.52189840
124PDGFRA0.50644483
125MAPK150.48517068
126JAK30.48206056
127MAPK120.47720613
128PBK0.47342065
129ERBB20.47035335
130TTN0.46507601
131PRKCE0.46467114
132TNK20.46153747
133RPS6KA60.44387686
134PAK40.43843631
135PRKAA20.43629754
136STK380.43384228
137FER0.42869098
138GSK3A0.41911157
139PRKD10.41847692
140CLK10.40690182
141MAPK40.40484057
142RPS6KC10.40325242
143RPS6KL10.40325242
144DAPK30.39764640
145MAPKAPK20.39567816
146RET0.38604643
147LIMK10.37896746
148MAP3K60.37760247
149PRKACG0.35812364
150CDC42BPA0.33587793

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.15938626
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.46272990
3Complement and coagulation cascades_Homo sapiens_hsa046103.39423588
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03728225
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.83529771
6Fatty acid degradation_Homo sapiens_hsa000712.27966773
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17457220
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16250676
9Caffeine metabolism_Homo sapiens_hsa002322.15306804
10Tryptophan metabolism_Homo sapiens_hsa003802.01358363
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98205401
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96945808
13PPAR signaling pathway_Homo sapiens_hsa033201.95856381
14Chemical carcinogenesis_Homo sapiens_hsa052041.92459355
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.91827449
16Peroxisome_Homo sapiens_hsa041461.88645251
17Nitrogen metabolism_Homo sapiens_hsa009101.72113795
18Fatty acid metabolism_Homo sapiens_hsa012121.70623436
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69734140
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.66788130
21Arginine biosynthesis_Homo sapiens_hsa002201.62320882
22Propanoate metabolism_Homo sapiens_hsa006401.62116543
23beta-Alanine metabolism_Homo sapiens_hsa004101.60104184
24* Retinol metabolism_Homo sapiens_hsa008301.59386801
25Starch and sucrose metabolism_Homo sapiens_hsa005001.55993357
26Histidine metabolism_Homo sapiens_hsa003401.55091331
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.51476066
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48466920
29Lysosome_Homo sapiens_hsa041421.46388091
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.39607467
31Other glycan degradation_Homo sapiens_hsa005111.37411755
32ABC transporters_Homo sapiens_hsa020101.27646384
33Linoleic acid metabolism_Homo sapiens_hsa005911.27492379
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27418626
35Butanoate metabolism_Homo sapiens_hsa006501.26432892
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.23039153
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22541284
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18911021
39Pertussis_Homo sapiens_hsa051331.18827022
40Fatty acid elongation_Homo sapiens_hsa000621.17236748
41Leishmaniasis_Homo sapiens_hsa051401.15949367
42Malaria_Homo sapiens_hsa051441.14773250
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13555279
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12623985
45Phenylalanine metabolism_Homo sapiens_hsa003601.11648054
46Vitamin digestion and absorption_Homo sapiens_hsa049771.08189309
47Fructose and mannose metabolism_Homo sapiens_hsa000510.99302657
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98891996
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98470329
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92256703
51Glutathione metabolism_Homo sapiens_hsa004800.91767156
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91035951
53Osteoclast differentiation_Homo sapiens_hsa043800.89308062
54Tyrosine metabolism_Homo sapiens_hsa003500.89043118
55Sulfur metabolism_Homo sapiens_hsa009200.88913797
56Legionellosis_Homo sapiens_hsa051340.86711564
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86253359
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86057980
59Prion diseases_Homo sapiens_hsa050200.83980894
60Steroid biosynthesis_Homo sapiens_hsa001000.83725949
61Bile secretion_Homo sapiens_hsa049760.80002549
62Fat digestion and absorption_Homo sapiens_hsa049750.79455142
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77645631
64Arachidonic acid metabolism_Homo sapiens_hsa005900.76997133
65Galactose metabolism_Homo sapiens_hsa000520.76552066
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74372206
67Sphingolipid metabolism_Homo sapiens_hsa006000.70749518
68Proteasome_Homo sapiens_hsa030500.69147514
69Glycerolipid metabolism_Homo sapiens_hsa005610.66220178
70Arginine and proline metabolism_Homo sapiens_hsa003300.65609722
71Sulfur relay system_Homo sapiens_hsa041220.62695307
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.62498589
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62214291
74Phagosome_Homo sapiens_hsa041450.61363399
75Carbon metabolism_Homo sapiens_hsa012000.60319346
76Selenocompound metabolism_Homo sapiens_hsa004500.60121838
77* Metabolic pathways_Homo sapiens_hsa011000.56585304
78Lysine degradation_Homo sapiens_hsa003100.56119329
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.55937159
80Tuberculosis_Homo sapiens_hsa051520.55470935
81Toxoplasmosis_Homo sapiens_hsa051450.53050713
82ECM-receptor interaction_Homo sapiens_hsa045120.52781302
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50741498
84Pyruvate metabolism_Homo sapiens_hsa006200.50265533
85Folate biosynthesis_Homo sapiens_hsa007900.49813153
86N-Glycan biosynthesis_Homo sapiens_hsa005100.49365892
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48210222
88Measles_Homo sapiens_hsa051620.48138987
89Rheumatoid arthritis_Homo sapiens_hsa053230.47891745
90Influenza A_Homo sapiens_hsa051640.47353079
91Pancreatic secretion_Homo sapiens_hsa049720.44839083
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43360797
93Amoebiasis_Homo sapiens_hsa051460.40958249
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.39273240
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39161498
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.38680004
97Fatty acid biosynthesis_Homo sapiens_hsa000610.36321901
98Salmonella infection_Homo sapiens_hsa051320.36036941
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.34571010
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33610568
101African trypanosomiasis_Homo sapiens_hsa051430.32678786
102Protein digestion and absorption_Homo sapiens_hsa049740.32493391
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31896173
104Mineral absorption_Homo sapiens_hsa049780.31455440
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30938843
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30847255
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.30201718
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29813873
109Biosynthesis of amino acids_Homo sapiens_hsa012300.29426500
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28923927
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28885958
112One carbon pool by folate_Homo sapiens_hsa006700.28567548
113Hepatitis C_Homo sapiens_hsa051600.28565906
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.28309910
115Insulin resistance_Homo sapiens_hsa049310.28105844
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.27232601
117Renin-angiotensin system_Homo sapiens_hsa046140.27056240
118Focal adhesion_Homo sapiens_hsa045100.26467725
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26097342
120Pentose phosphate pathway_Homo sapiens_hsa000300.25472732
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25422062
122Vitamin B6 metabolism_Homo sapiens_hsa007500.25364194
123Tight junction_Homo sapiens_hsa045300.23676873
124Hematopoietic cell lineage_Homo sapiens_hsa046400.23533294
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22765389
126Circadian rhythm_Homo sapiens_hsa047100.21605902
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.20591698
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18940041
129Vibrio cholerae infection_Homo sapiens_hsa051100.11890151

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