DHDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.02947438
2fat-soluble vitamin biosynthetic process (GO:0042362)7.12111348
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.00938776
4L-phenylalanine catabolic process (GO:0006559)7.00938776
5L-phenylalanine metabolic process (GO:0006558)6.69259800
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69259800
7regulation of guanylate cyclase activity (GO:0031282)6.60308005
8aromatic amino acid family catabolic process (GO:0009074)6.55397558
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.36982747
10indole-containing compound catabolic process (GO:0042436)6.16418556
11indolalkylamine catabolic process (GO:0046218)6.16418556
12tryptophan catabolic process (GO:0006569)6.16418556
13NADH metabolic process (GO:0006734)6.15430014
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.93425230
15epoxygenase P450 pathway (GO:0019373)5.87623347
16tryptophan metabolic process (GO:0006568)5.81257683
17kynurenine metabolic process (GO:0070189)5.73844394
18lipoprotein transport (GO:0042953)5.73032037
19bile acid biosynthetic process (GO:0006699)5.62194735
20fructose metabolic process (GO:0006000)5.47963706
21urea metabolic process (GO:0019627)5.41061941
22urea cycle (GO:0000050)5.41061941
23positive regulation of guanylate cyclase activity (GO:0031284)5.30595571
24regulation of cGMP biosynthetic process (GO:0030826)5.28834827
25complement activation, alternative pathway (GO:0006957)5.18245306
26alpha-linolenic acid metabolic process (GO:0036109)5.16959678
27glyoxylate metabolic process (GO:0046487)5.15243352
28high-density lipoprotein particle remodeling (GO:0034375)5.13106808
29glycosphingolipid catabolic process (GO:0046479)5.08956111
30nitrogen cycle metabolic process (GO:0071941)5.04872796
31serine family amino acid catabolic process (GO:0009071)5.03937563
32protein carboxylation (GO:0018214)4.97139268
33peptidyl-glutamic acid carboxylation (GO:0017187)4.97139268
34sulfur amino acid catabolic process (GO:0000098)4.96156744
35regulation of fibrinolysis (GO:0051917)4.93944791
36glycolipid catabolic process (GO:0019377)4.93819750
37regulation of protein activation cascade (GO:2000257)4.89499472
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88959081
39bile acid metabolic process (GO:0008206)4.87961039
40negative regulation of fibrinolysis (GO:0051918)4.86780829
41intestinal absorption (GO:0050892)4.84944876
42regulation of triglyceride catabolic process (GO:0010896)4.81512965
43aromatic amino acid family metabolic process (GO:0009072)4.79364232
44cysteine metabolic process (GO:0006534)4.78480948
45amino-acid betaine metabolic process (GO:0006577)4.69256451
46regulation of cholesterol esterification (GO:0010872)4.69107872
47triglyceride homeostasis (GO:0070328)4.65636105
48acylglycerol homeostasis (GO:0055090)4.65636105
49oligosaccharide catabolic process (GO:0009313)4.61137956
50regulation of complement activation (GO:0030449)4.58184506
51tyrosine metabolic process (GO:0006570)4.58007777
52amine catabolic process (GO:0009310)4.56462719
53cellular biogenic amine catabolic process (GO:0042402)4.56462719
54fat-soluble vitamin metabolic process (GO:0006775)4.52161330
55vitamin biosynthetic process (GO:0009110)4.51448400
56protein-lipid complex remodeling (GO:0034368)4.50998328
57macromolecular complex remodeling (GO:0034367)4.50998328
58plasma lipoprotein particle remodeling (GO:0034369)4.50998328
59homocysteine metabolic process (GO:0050667)4.50395325
60regulation of cGMP metabolic process (GO:0030823)4.48970717
61alpha-amino acid catabolic process (GO:1901606)4.48360805
62vitamin A metabolic process (GO:0006776)4.46460568
63reverse cholesterol transport (GO:0043691)4.46430849
64drug metabolic process (GO:0017144)4.45721875
65receptor guanylyl cyclase signaling pathway (GO:0007168)4.44830064
66indolalkylamine metabolic process (GO:0006586)4.43523367
67phospholipid efflux (GO:0033700)4.43053640
68positive regulation of cGMP biosynthetic process (GO:0030828)4.42262052
69vitamin D metabolic process (GO:0042359)4.41765781
70diacylglycerol metabolic process (GO:0046339)4.38069377
71imidazole-containing compound metabolic process (GO:0052803)4.36046533
72heme transport (GO:0015886)4.32598199
73protein-lipid complex assembly (GO:0065005)4.31127743
74cellular glucuronidation (GO:0052695)4.30791946
75peptide hormone processing (GO:0016486)4.27340284
76adhesion of symbiont to host cell (GO:0044650)4.25640270
77virion attachment to host cell (GO:0019062)4.25640270
78plasma lipoprotein particle clearance (GO:0034381)4.24654933
79coenzyme catabolic process (GO:0009109)4.23988176
80bile acid and bile salt transport (GO:0015721)4.22337642
81glycine metabolic process (GO:0006544)4.21987464
82vitamin transport (GO:0051180)4.21967247
83cellular amino acid catabolic process (GO:0009063)4.11505814
84ceramide catabolic process (GO:0046514)4.10352725
85benzene-containing compound metabolic process (GO:0042537)4.08157508
86glycosylceramide metabolic process (GO:0006677)4.05992279
87regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.03568638
88endocrine process (GO:0050886)4.03568638
89regulation of systemic arterial blood pressure by hormone (GO:0001990)4.03568638
90lysine catabolic process (GO:0006554)4.03095025
91lysine metabolic process (GO:0006553)4.03095025
92ethanol oxidation (GO:0006069)4.02654794
93NAD biosynthetic process (GO:0009435)4.01947951
94low-density lipoprotein particle remodeling (GO:0034374)4.00635489
95negative regulation of lipase activity (GO:0060192)4.00429524
96positive regulation of triglyceride lipase activity (GO:0061365)3.93888899
97positive regulation of lipoprotein lipase activity (GO:0051006)3.93888899
98uronic acid metabolic process (GO:0006063)3.92319600
99glucuronate metabolic process (GO:0019585)3.92319600
100L-ascorbic acid metabolic process (GO:0019852)3.91137146
101cholesterol efflux (GO:0033344)3.90876603
102serine family amino acid metabolic process (GO:0009069)3.90547016
103blood coagulation, intrinsic pathway (GO:0007597)3.89595103
104negative regulation of sterol transport (GO:0032372)3.88311038
105negative regulation of cholesterol transport (GO:0032375)3.88311038
106pyridine nucleotide biosynthetic process (GO:0019363)3.87712320
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.87712320
108aldehyde catabolic process (GO:0046185)3.86678182
109quinone biosynthetic process (GO:1901663)3.84004572
110cellular ketone body metabolic process (GO:0046950)3.82942509
111nucleoside diphosphate biosynthetic process (GO:0009133)3.82319254
112cGMP biosynthetic process (GO:0006182)3.80743847
113carboxylic acid catabolic process (GO:0046395)3.79473021
114organic acid catabolic process (GO:0016054)3.79473021
115positive regulation of cGMP metabolic process (GO:0030825)3.79390831
116regulation of systemic arterial blood pressure (GO:0003073)3.78909890
117phospholipid homeostasis (GO:0055091)3.77781534
118very-low-density lipoprotein particle assembly (GO:0034379)3.76385222
119fatty acid beta-oxidation (GO:0006635)3.73440346
120plasma lipoprotein particle assembly (GO:0034377)3.71866836
121fatty acid oxidation (GO:0019395)3.70613397
122positive regulation of lipid catabolic process (GO:0050996)3.68201645
123glutamine family amino acid biosynthetic process (GO:0009084)3.67917245
124arginine metabolic process (GO:0006525)3.67172900
125sphingolipid catabolic process (GO:0030149)3.67165887
126acetyl-CoA metabolic process (GO:0006084)3.66315503
127protein activation cascade (GO:0072376)3.65156546
128fibrinolysis (GO:0042730)3.65125000
129lipid oxidation (GO:0034440)3.64105475
130regulation of bile acid biosynthetic process (GO:0070857)3.63830166
131short-chain fatty acid metabolic process (GO:0046459)3.63130915
132monocarboxylic acid catabolic process (GO:0072329)3.61525352
133adhesion of symbiont to host (GO:0044406)3.61144707
134carnitine metabolic process (GO:0009437)3.61054042
135cellular response to nitric oxide (GO:0071732)3.60561280
136cofactor catabolic process (GO:0051187)3.60082948
137complement activation (GO:0006956)3.59346050
138glutamate metabolic process (GO:0006536)3.59273622
139serine family amino acid biosynthetic process (GO:0009070)3.58568885
140response to nitrosative stress (GO:0051409)3.57968060
141cellular modified amino acid catabolic process (GO:0042219)3.57739933
142valine metabolic process (GO:0006573)3.57724390
143fatty acid catabolic process (GO:0009062)3.55677025
144drug catabolic process (GO:0042737)3.55604357
145cholesterol homeostasis (GO:0042632)3.54876673
146complement activation, classical pathway (GO:0006958)3.54519933
147glycine transport (GO:0015816)3.52239092
148membrane lipid catabolic process (GO:0046466)3.51260088
149cobalamin metabolic process (GO:0009235)3.48773950
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.46549143
151vitamin transmembrane transport (GO:0035461)3.43627221
152cellular response to oxygen radical (GO:0071450)3.37429061
153removal of superoxide radicals (GO:0019430)3.37429061
154cellular response to superoxide (GO:0071451)3.37429061
155neutral amino acid transport (GO:0015804)3.28053523
156digestion (GO:0007586)3.25774817
157nonribosomal peptide biosynthetic process (GO:0019184)3.21263587
158peptide catabolic process (GO:0043171)3.19955972
159renal system process involved in regulation of blood volume (GO:0001977)3.18916736
160lipoprotein metabolic process (GO:0042157)3.18100321
161glutathione biosynthetic process (GO:0006750)3.17641108
162GDP-mannose metabolic process (GO:0019673)3.15362134
163hormone catabolic process (GO:0042447)3.15036847
164glycerol metabolic process (GO:0006071)3.14791067
165regulation of cholesterol homeostasis (GO:2000188)3.14038711
166glycoside metabolic process (GO:0016137)3.13840128
167urate metabolic process (GO:0046415)3.13290577
168modified amino acid transport (GO:0072337)3.08262438
169glutathione metabolic process (GO:0006749)3.07111658
170iron coordination entity transport (GO:1901678)3.00407170
171very long-chain fatty acid metabolic process (GO:0000038)2.97227256
172positive regulation of triglyceride metabolic process (GO:0090208)2.96298076
173regulation of vitamin metabolic process (GO:0030656)2.96284727
174glutathione derivative metabolic process (GO:1901685)2.95440642
175glutathione derivative biosynthetic process (GO:1901687)2.95440642
1763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.94282541
177purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.94282541
178alditol metabolic process (GO:0019400)2.93618132
179sterol homeostasis (GO:0055092)2.88220326
180eosinophil chemotaxis (GO:0048245)2.86283538
181flavonoid metabolic process (GO:0009812)2.86044454
182sphingomyelin metabolic process (GO:0006684)2.82667009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.79032269
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.36288882
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.60395116
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.99998661
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.67473298
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.09868416
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06392628
8CDX2_20551321_ChIP-Seq_CACO-2_Human4.09334358
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.08047929
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.76721186
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.10726902
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06313125
13ZNF263_19887448_ChIP-Seq_K562_Human2.45014714
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21496458
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20994678
16GATA6_25053715_ChIP-Seq_YYC3_Human2.16700976
17NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.11305743
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09023570
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7666291
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.95796961
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85097890
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83113013
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76378998
24HTT_18923047_ChIP-ChIP_STHdh_Human1.72546563
25GATA1_22025678_ChIP-Seq_K562_Human1.71399640
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69108039
27SOX2_20726797_ChIP-Seq_SW620_Human1.67768134
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.67266344
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.66060514
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65857325
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.64961985
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58888748
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56636846
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55453772
35SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55336608
36BCOR_27268052_Chip-Seq_Bcells_Human1.49113594
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.48962858
38BCL6_27268052_Chip-Seq_Bcells_Human1.44914247
39NANOG_20526341_ChIP-Seq_ESCs_Human1.44884487
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.41960351
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40789412
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39828585
43SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33822371
44LXR_22292898_ChIP-Seq_THP-1_Human1.33292574
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30318416
46* SA1_27219007_Chip-Seq_Bcells_Human1.28963218
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28859886
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.28604396
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27708311
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25526351
51HNF4A_19822575_ChIP-Seq_HepG2_Human1.25371063
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.24703149
53GABP_19822575_ChIP-Seq_HepG2_Human1.23626271
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21899529
55PHF8_20622854_ChIP-Seq_HELA_Human1.21148828
56* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20619280
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17350781
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17296674
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.16583857
60E2F1_20622854_ChIP-Seq_HELA_Human1.13997316
61XRN2_22483619_ChIP-Seq_HELA_Human1.13090581
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.13028005
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13000603
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12444258
65* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11560466
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10246731
67* CTCF_27219007_Chip-Seq_Bcells_Human1.09732926
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08660826
69TAF2_19829295_ChIP-Seq_ESCs_Human1.07607233
70CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07540404
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06801550
72VDR_22108803_ChIP-Seq_LS180_Human1.06761265
73MYC_19829295_ChIP-Seq_ESCs_Human1.06756803
74IRF1_19129219_ChIP-ChIP_H3396_Human1.06678439
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.06055417
76CTCF_20526341_ChIP-Seq_ESCs_Human1.06048381
77NCOR_22424771_ChIP-Seq_293T_Human1.05866002
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03955785
79DCP1A_22483619_ChIP-Seq_HELA_Human1.03488571
80CDX2_22108803_ChIP-Seq_LS180_Human1.02655628
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02200638
82AR_21909140_ChIP-Seq_LNCAP_Human0.99335998
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99237466
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.99237466
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98232978
86FOXO3_23340844_ChIP-Seq_DLD1_Human0.97984767
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.97645771
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97563944
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97039103
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96408889
91SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95842320
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.95247833
93TAF15_26573619_Chip-Seq_HEK293_Human0.94988216
94P53_21459846_ChIP-Seq_SAOS-2_Human0.94925065
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94588815
96GATA3_21867929_ChIP-Seq_CD8_Mouse0.93890858
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.93859680
98OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93642622
99STAT1_20625510_ChIP-Seq_HELA_Human0.93135409
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92750816
101CTCF_26484167_Chip-Seq_Bcells_Mouse0.91878860
102PHF8_20622853_ChIP-Seq_HELA_Human0.91688260
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91501364
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89337520
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86790191
106CLOCK_20551151_ChIP-Seq_293T_Human0.85283964
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84992813
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84904386
109RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84263407
110ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82347964
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.81604116
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.81390455
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80607477
114STAT1_17558387_ChIP-Seq_HELA_Human0.79854322
115AR_20517297_ChIP-Seq_VCAP_Human0.79802556
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77323905
117OCT4_21477851_ChIP-Seq_ESCs_Mouse0.76523749
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75346466
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.72535332
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71027492
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70997643
122SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69405098
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69100330
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69095845
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68929353
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66766259
127OCT4_18555785_Chip-Seq_ESCs_Mouse0.66509462
128ESRRB_18555785_Chip-Seq_ESCs_Mouse0.66187672
129GATA4_25053715_ChIP-Seq_YYC3_Human0.66021043
130PU1_27457419_Chip-Seq_LIVER_Mouse0.64800207
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.63791475
132CEBPB_22108803_ChIP-Seq_LS180_Human0.63117920
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63057705
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62057548
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62057548
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.61531107
137STAT3_18555785_Chip-Seq_ESCs_Mouse0.61362280
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.61242685
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60860995
140P53_22387025_ChIP-Seq_ESCs_Mouse0.60530475
141* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60432755
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60115999
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.60060820
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59771681
145P300_18555785_Chip-Seq_ESCs_Mouse0.59715184
146* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.59153381
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58696277
148ZFX_18555785_Chip-Seq_ESCs_Mouse0.58538002
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58196897
150RARA_24833708_ChIP-Seq_LIVER_Mouse0.57746074
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.57356917
152NMYC_18555785_Chip-Seq_ESCs_Mouse0.56315137
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.55523321
154ERG_20517297_ChIP-Seq_VCAP_Human0.54810882
155BCAT_22108803_ChIP-Seq_LS180_Human0.54148210
156NOTCH1_21737748_ChIP-Seq_TLL_Human0.52776249
157EGR1_19032775_ChIP-ChIP_M12_Human0.52769509
158SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.52696712
159PIAS1_25552417_ChIP-Seq_VCAP_Human0.52688964
160CBP_21632823_ChIP-Seq_H3396_Human0.52585412
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.51664749
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.51464130
163SALL4_18804426_ChIP-ChIP_XEN_Mouse0.50938340
164RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.50855956
165ZFP57_27257070_Chip-Seq_ESCs_Mouse0.50415207
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.50253602
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.49826601
168AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.49488734
169E2F1_18555785_Chip-Seq_ESCs_Mouse0.49450596
170FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49416293
171PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49408918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02961464
2MP0005360_urolithiasis6.76513479
3MP0005085_abnormal_gallbladder_physiolo6.08861585
4MP0005365_abnormal_bile_salt5.97693577
5MP0008875_abnormal_xenobiotic_pharmacok4.93065110
6MP0004147_increased_porphyrin_level4.55841061
7MP0003806_abnormal_nucleotide_metabolis3.72249825
8MP0003252_abnormal_bile_duct3.65637322
9MP0010329_abnormal_lipoprotein_level3.62683475
10MP0003183_abnormal_peptide_metabolism3.56842049
11MP0004264_abnormal_extraembryonic_tissu2.95132374
12MP0003195_calcinosis2.77250531
13MP0010234_abnormal_vibrissa_follicle2.66545175
14MP0005332_abnormal_amino_acid2.62036190
15MP0009840_abnormal_foam_cell2.57873212
16MP0005083_abnormal_biliary_tract2.50985041
17MP0005670_abnormal_white_adipose2.35059129
18MP0001666_abnormal_nutrient_absorption2.25696442
19MP0003191_abnormal_cellular_cholesterol2.22646057
20MP0004019_abnormal_vitamin_homeostasis2.20458701
21MP0002118_abnormal_lipid_homeostasis2.17019399
22MP0000609_abnormal_liver_physiology2.12256793
23MP0005058_abnormal_lysosome_morphology2.04034216
24MP0009697_abnormal_copulation2.03865200
25MP0001764_abnormal_homeostasis2.03451054
26MP0002138_abnormal_hepatobiliary_system1.97764655
27MP0003868_abnormal_feces_composition1.92876902
28MP0004270_analgesia1.90476368
29MP0002822_catalepsy1.85484488
30MP0005319_abnormal_enzyme/_coenzyme1.82371996
31MP0000372_irregular_coat_pigmentation1.76571555
32MP0003186_abnormal_redox_activity1.72965292
33MP0003011_delayed_dark_adaptation1.66255176
34MP0002876_abnormal_thyroid_physiology1.61405936
35MP0005584_abnormal_enzyme/coenzyme_acti1.54076458
36MP0005451_abnormal_body_composition1.53266137
37MP0005647_abnormal_sex_gland1.40313691
38MP0001664_abnormal_digestion1.40285379
39MP0009764_decreased_sensitivity_to1.28218473
40MP0008260_abnormal_autophagy1.25868237
41MP0000678_abnormal_parathyroid_gland1.25436243
42MP0003724_increased_susceptibility_to1.24991488
43MP0000538_abnormal_urinary_bladder1.24942768
44MP0005409_darkened_coat_color1.21931259
45MP0000490_abnormal_crypts_of1.20598714
46MP0002102_abnormal_ear_morphology1.20307575
47MP0009643_abnormal_urine_homeostasis1.18177931
48MP0003879_abnormal_hair_cell1.17010606
49MP0001986_abnormal_taste_sensitivity1.16884927
50MP0002971_abnormal_brown_adipose1.16038552
51MP0010155_abnormal_intestine_physiology1.13557325
52MP0004130_abnormal_muscle_cell1.13285424
53MP0001765_abnormal_ion_homeostasis1.12890751
54MP0002909_abnormal_adrenal_gland1.12287670
55MP0009763_increased_sensitivity_to1.11090387
56MP0005334_abnormal_fat_pad1.10523214
57MP0006036_abnormal_mitochondrial_physio1.09632468
58MP0000598_abnormal_liver_morphology1.08054744
59MP0000516_abnormal_urinary_system1.06544233
60MP0005367_renal/urinary_system_phenotyp1.06544233
61MP0005666_abnormal_adipose_tissue1.03938759
62MP0004381_abnormal_hair_follicle1.02938386
63MP0008469_abnormal_protein_level1.02881064
64MP0003136_yellow_coat_color1.00004907
65MP0002254_reproductive_system_inflammat0.98078660
66MP0005535_abnormal_body_temperature0.95406131
67MP0005084_abnormal_gallbladder_morpholo0.94684852
68MP0001501_abnormal_sleep_pattern0.94633000
69MP0001661_extended_life_span0.92620893
70MP0002078_abnormal_glucose_homeostasis0.90976594
71MP0009642_abnormal_blood_homeostasis0.90424483
72MP0005408_hypopigmentation0.89926546
73MP0005501_abnormal_skin_physiology0.89864841
74MP0002098_abnormal_vibrissa_morphology0.88235790
75MP0001529_abnormal_vocalization0.88219309
76MP0003656_abnormal_erythrocyte_physiolo0.87925307
77MP0004782_abnormal_surfactant_physiolog0.86209092
78MP0005636_abnormal_mineral_homeostasis0.85732612
79MP0001188_hyperpigmentation0.85722772
80MP0010368_abnormal_lymphatic_system0.85425157
81MP0009765_abnormal_xenobiotic_induced0.83078309
82MP0000462_abnormal_digestive_system0.82685567
83MP0005376_homeostasis/metabolism_phenot0.81442889
84MP0000566_synostosis0.78404212
85MP0000015_abnormal_ear_pigmentation0.78362300
86MP0002132_abnormal_respiratory_system0.73814243
87MP0004043_abnormal_pH_regulation0.73442928
88MP0009115_abnormal_fat_cell0.73223832
89MP0002938_white_spotting0.73047054
90MP0002090_abnormal_vision0.72517134
91MP0000477_abnormal_intestine_morphology0.72152114
92MP0003878_abnormal_ear_physiology0.71679847
93MP0005377_hearing/vestibular/ear_phenot0.71679847
94MP0005166_decreased_susceptibility_to0.69496254
95MP0003436_decreased_susceptibility_to0.68749874
96MP0006082_CNS_inflammation0.66693415
97MP0005257_abnormal_intraocular_pressure0.65428052
98MP0005266_abnormal_metabolism0.65201309
99MP0005075_abnormal_melanosome_morpholog0.64933041
100MP0003718_maternal_effect0.64471157
101MP0005464_abnormal_platelet_physiology0.64069430
102MP0005220_abnormal_exocrine_pancreas0.63252144
103MP0005448_abnormal_energy_balance0.62734571
104MP0006035_abnormal_mitochondrial_morpho0.61277392
105MP0001853_heart_inflammation0.61152829
106MP0003690_abnormal_glial_cell0.60053667
107MP0000013_abnormal_adipose_tissue0.59002302
108MP0002837_dystrophic_cardiac_calcinosis0.57016878
109MP0001756_abnormal_urination0.56921015
110MP0009333_abnormal_splenocyte_physiolog0.56405522
111MP0000639_abnormal_adrenal_gland0.54925104
112MP0009379_abnormal_foot_pigmentation0.54808836
113MP0001485_abnormal_pinna_reflex0.53793872
114MP0003953_abnormal_hormone_level0.53494573
115MP0005395_other_phenotype0.52751630
116MP0002970_abnormal_white_adipose0.52577253
117MP0005248_abnormal_Harderian_gland0.52067748
118MP0002928_abnormal_bile_duct0.51858672
119MP0010352_gastrointestinal_tract_polyps0.51532400
120MP0006292_abnormal_olfactory_placode0.51515278
121MP0008995_early_reproductive_senescence0.49379670
122MP0003866_abnormal_defecation0.48954733
123MP0002069_abnormal_eating/drinking_beha0.46431392
124MP0002693_abnormal_pancreas_physiology0.45577954
125MP0000537_abnormal_urethra_morphology0.45124748
126MP0002136_abnormal_kidney_physiology0.43520892
127MP0005174_abnormal_tail_pigmentation0.43244006
128MP0009785_altered_susceptibility_to0.42882178
129MP0010678_abnormal_skin_adnexa0.42112609
130MP0005379_endocrine/exocrine_gland_phen0.41690240
131MP0004185_abnormal_adipocyte_glucose0.39793486
132MP0002419_abnormal_innate_immunity0.39419431
133MP0005375_adipose_tissue_phenotype0.38775767
134MP0001835_abnormal_antigen_presentation0.38738085
135MP0001845_abnormal_inflammatory_respons0.37847426
136MP0000230_abnormal_systemic_arterial0.37543681
137MP0000604_amyloidosis0.37447302
138MP0003638_abnormal_response/metabolism_0.37350963
139MP0005025_abnormal_response_to0.35606316
140MP0001881_abnormal_mammary_gland0.35465520
141MP0009672_abnormal_birth_weight0.34790766
142MP0000427_abnormal_hair_cycle0.33959432
143MP0008873_increased_physiological_sensi0.33703304
144MP0001324_abnormal_eye_pigmentation0.32516014
145MP0000579_abnormal_nail_morphology0.32326840
146MP0008872_abnormal_physiological_respon0.32250293
147MP0008874_decreased_physiological_sensi0.31619618
148MP0003959_abnormal_lean_body0.31458947
149MP0000249_abnormal_blood_vessel0.31266350
150MP0005452_abnormal_adipose_tissue0.30815546

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.69538430
2Intrahepatic cholestasis (HP:0001406)6.59183466
3Prolonged partial thromboplastin time (HP:0003645)6.59034482
4Deep venous thrombosis (HP:0002625)6.13852303
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02245963
6Xanthomatosis (HP:0000991)5.49735440
7Hypobetalipoproteinemia (HP:0003563)5.45848642
8Malnutrition (HP:0004395)5.40460505
9Hyperlipoproteinemia (HP:0010980)5.15224530
10Complement deficiency (HP:0004431)5.13231975
11Joint hemorrhage (HP:0005261)5.04496673
12Hyperglycinemia (HP:0002154)4.71307935
13Abnormality of vitamin B metabolism (HP:0004340)4.64847658
14Hyperglycinuria (HP:0003108)4.56793024
15Abnormality of the vitamin B12 metabolism (HP:0004341)4.46768644
16Hyperammonemia (HP:0001987)4.34823193
17Epidermoid cyst (HP:0200040)4.32867759
18Hypolipoproteinemia (HP:0010981)4.28432745
19Abnormality of glycine metabolism (HP:0010895)4.19998578
20Abnormality of serine family amino acid metabolism (HP:0010894)4.19998578
21Widely patent fontanelles and sutures (HP:0004492)4.19861241
22Abnormality of methionine metabolism (HP:0010901)4.19673537
23Confusion (HP:0001289)4.11533246
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06518334
25Hypoglycemic coma (HP:0001325)4.03734672
26Ketosis (HP:0001946)3.97460585
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97423360
28Abnormality of the common coagulation pathway (HP:0010990)3.96609000
29Abnormality of pyrimidine metabolism (HP:0004353)3.95442369
30Hypoalphalipoproteinemia (HP:0003233)3.94637037
31Conjugated hyperbilirubinemia (HP:0002908)3.91730902
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.82373120
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.76288659
34Fat malabsorption (HP:0002630)3.74461729
35Abnormality of complement system (HP:0005339)3.73800461
36Abnormality of fatty-acid metabolism (HP:0004359)3.67492585
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.58017217
38Hypercholesterolemia (HP:0003124)3.47586510
39Ileus (HP:0002595)3.44260365
40Abnormality of the intrinsic pathway (HP:0010989)3.41723365
41Abnormality of serum amino acid levels (HP:0003112)3.34760962
42Reticulocytopenia (HP:0001896)3.18925341
43Congenital sensorineural hearing impairment (HP:0008527)3.15767509
44Hyperbilirubinemia (HP:0002904)3.10757847
45Delayed CNS myelination (HP:0002188)3.05805810
46Chronic diarrhea (HP:0002028)3.05480413
47Renal cortical cysts (HP:0000803)3.02747438
48Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01330679
49Dicarboxylic aciduria (HP:0003215)3.01330679
50Megaloblastic anemia (HP:0001889)3.01175721
51Abnormality of the costochondral junction (HP:0000919)2.96445204
52Abnormality of nucleobase metabolism (HP:0010932)2.94839883
53Steatorrhea (HP:0002570)2.90225712
54Myocardial infarction (HP:0001658)2.89371374
55Systemic lupus erythematosus (HP:0002725)2.88687853
56Lethargy (HP:0001254)2.85029424
57Ketoacidosis (HP:0001993)2.83269432
58Abnormal urine phosphate concentration (HP:0012599)2.83096507
59Gout (HP:0001997)2.81993368
60Metabolic acidosis (HP:0001942)2.79785865
61Wide cranial sutures (HP:0010537)2.75425340
62Cerebral edema (HP:0002181)2.74630024
63Hyperphosphaturia (HP:0003109)2.71248257
64Delayed epiphyseal ossification (HP:0002663)2.69952116
65Hypochromic microcytic anemia (HP:0004840)2.67084416
66Nephrolithiasis (HP:0000787)2.63925533
67Hypoglycemic seizures (HP:0002173)2.63050123
68Abnormality of glycolipid metabolism (HP:0010969)2.61901876
69Abnormality of liposaccharide metabolism (HP:0010968)2.61901876
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.61901876
71Increased purine levels (HP:0004368)2.60630282
72Hyperuricemia (HP:0002149)2.60630282
73Acute encephalopathy (HP:0006846)2.60351341
74Recurrent gram-negative bacterial infections (HP:0005420)2.58398764
75Thin bony cortex (HP:0002753)2.57000286
76Spontaneous abortion (HP:0005268)2.55555977
77Methylmalonic aciduria (HP:0012120)2.55026795
78Glomerulonephritis (HP:0000099)2.54045008
79Generalized aminoaciduria (HP:0002909)2.52565329
80Vacuolated lymphocytes (HP:0001922)2.51683796
81Hepatocellular carcinoma (HP:0001402)2.48348304
82Macrocytic anemia (HP:0001972)2.45625847
83Abnormality of purine metabolism (HP:0004352)2.44538641
84Vascular calcification (HP:0004934)2.43754704
85Pancreatitis (HP:0001733)2.39236071
86Skin nodule (HP:0200036)2.37061797
87Hypophosphatemia (HP:0002148)2.35986592
88Gingival bleeding (HP:0000225)2.33008801
89Acute necrotizing encephalopathy (HP:0006965)2.31779918
90Posterior subcapsular cataract (HP:0007787)2.31618731
91Abnormality of magnesium homeostasis (HP:0004921)2.31161822
92Menorrhagia (HP:0000132)2.30953329
93Enlarged epiphyses (HP:0010580)2.30765078
94Abnormal mitochondria in muscle tissue (HP:0008316)2.26426001
95Acanthocytosis (HP:0001927)2.25965164
96Enlarged kidneys (HP:0000105)2.23135529
97Proximal tubulopathy (HP:0000114)2.22573151
98Increased CSF lactate (HP:0002490)2.22257448
99Metaphyseal irregularity (HP:0003025)2.20080342
100Opisthotonus (HP:0002179)2.19010399
101Hypertriglyceridemia (HP:0002155)2.18598839
102Vomiting (HP:0002013)2.17621390
103Renal tubular dysfunction (HP:0000124)2.14838583
104Mitochondrial inheritance (HP:0001427)2.14742106
105Abnormal biliary tract physiology (HP:0012439)2.14218023
106Bile duct proliferation (HP:0001408)2.14218023
107Brushfield spots (HP:0001088)2.12330011
108Nausea (HP:0002018)2.11333583
109Hypoalbuminemia (HP:0003073)2.08745708
110Abnormal albumin level (HP:0012116)2.08745708
111Cardiovascular calcification (HP:0011915)2.08381435
112Late onset (HP:0003584)2.06939836
113Elevated hepatic transaminases (HP:0002910)2.06373090
114Irritability (HP:0000737)2.04361931
115Hyperinsulinemic hypoglycemia (HP:0000825)2.04035844
116Axonal loss (HP:0003447)2.03954180
117Mitral stenosis (HP:0001718)2.01002698
118Amyloidosis (HP:0011034)2.00590264
119Lipid accumulation in hepatocytes (HP:0006561)2.00292082
120Abnormality of proline metabolism (HP:0010907)1.97361802
121Hydroxyprolinuria (HP:0003080)1.97361802
122Abnormality of urine glucose concentration (HP:0011016)1.97000003
123Glycosuria (HP:0003076)1.97000003
124Abnormal gallbladder morphology (HP:0012437)1.95014407
125Hemorrhage of the eye (HP:0011885)1.94187199
126Neonatal onset (HP:0003623)1.94185323
127Hypophosphatemic rickets (HP:0004912)1.93307781
128Reduced antithrombin III activity (HP:0001976)1.92503815
129Pigmentary retinal degeneration (HP:0001146)1.91586332
130Progressive macrocephaly (HP:0004481)1.89371918
131Fair hair (HP:0002286)1.89141133
132Focal segmental glomerulosclerosis (HP:0000097)1.88924762
133Thrombophlebitis (HP:0004418)1.84672813
134Esophageal varix (HP:0002040)1.84489391
135Retinal atrophy (HP:0001105)1.84047690
136Hepatocellular necrosis (HP:0001404)1.83914884
137Hypotension (HP:0002615)1.83829765
138Poikilocytosis (HP:0004447)1.83670255
139Hyperglycemia (HP:0003074)1.83413388
140Cholelithiasis (HP:0001081)1.82895533
141Abdominal distention (HP:0003270)1.82328306
142Increased hepatocellular lipid droplets (HP:0006565)1.81878004
143Hepatic necrosis (HP:0002605)1.81101353
144Rickets (HP:0002748)1.80454986
145Symptomatic seizures (HP:0011145)1.79604027
146Potter facies (HP:0002009)1.78830928
147Facial shape deformation (HP:0011334)1.78830928
148Alkalosis (HP:0001948)1.78547677
149Cerebral palsy (HP:0100021)1.74290583
150Increased muscle lipid content (HP:0009058)1.74155030
151Abnormality of vitamin metabolism (HP:0100508)1.73460077
152CNS demyelination (HP:0007305)1.71583721
153Hyperparathyroidism (HP:0000843)1.68519251
154Lactic acidosis (HP:0003128)1.67709310
155Decreased circulating renin level (HP:0003351)1.65439395
156Increased intramyocellular lipid droplets (HP:0012240)1.65005667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.03163027
2BCKDK5.79674503
3IRAK33.61597620
4SIK13.51047864
5INSRR3.46410788
6MST43.42404303
7MAP3K123.21645553
8TAOK32.88217434
9EPHA22.78590159
10FGFR42.76344162
11MAP3K102.52528329
12PRKG22.48100314
13WNK32.47381736
14TESK22.38101535
15IRAK42.12547812
16PDK22.09288067
17PINK12.04888659
18MAP3K142.02499152
19IRAK22.00979235
20PIK3CG1.94397926
21ERN11.91208346
22STK161.85538247
23TAOK11.81447908
24NEK91.75828180
25ERBB41.68030535
26CAMK1D1.66645608
27MST1R1.64946510
28ZAK1.62113762
29STK38L1.58377313
30EPHA41.54855808
31IRAK11.53035254
32STK391.52049045
33TYK21.51996559
34PRKAA21.51741833
35TESK11.51732485
36FLT31.48107792
37TIE11.47999495
38EPHB21.45408157
39EIF2AK21.38260946
40TRIM281.36783368
41MAPK111.35667304
42FRK1.28205153
43MAP2K41.28016401
44GRK11.24742123
45NME11.22937379
46CDK191.22658711
47MAP3K111.21747356
48NLK1.18543759
49MAPK151.15610354
50TXK1.13835236
51CASK1.08819952
52IKBKE1.08107875
53MAP2K31.07684091
54TEC1.07292170
55ABL21.05731423
56MAP3K21.05422168
57SGK21.04013008
58OXSR11.02190455
59MAP3K51.01541875
60JAK10.99775023
61LATS10.98912444
62BRD40.98531162
63NEK10.95797857
64TGFBR20.93515110
65MAP2K70.92393911
66ADRBK20.89476306
67MUSK0.88748495
68PIM10.88613487
69PIK3CA0.87964946
70BLK0.87865473
71KDR0.87829180
72PIM20.87609176
73ICK0.87256159
74MATK0.86050499
75BUB10.84568005
76MAPK40.83969103
77DYRK30.82858363
78PRKCI0.82793760
79WNK40.82610208
80OBSCN0.81754951
81JAK20.78782145
82MAP3K40.77760696
83CAMK1G0.76193888
84MAP2K60.75790182
85PLK40.75781920
86DMPK0.74580803
87STK40.73483650
88IKBKB0.73201448
89EIF2AK10.73016018
90TNIK0.71745477
91TBK10.70569491
92AKT30.70149020
93MKNK20.69831848
94BMPR20.68731253
95KIT0.68065307
96CSK0.67520470
97NUAK10.67243449
98CDK60.66804883
99CSNK1G30.66624775
100MAP4K20.64023324
101TAOK20.63387547
102MET0.63234628
103PRKAA10.62543027
104SIK30.62475309
105SGK30.62341935
106FGFR30.62132952
107MAPK120.61446100
108PTK60.58964442
109MAPK70.58687986
110TNK20.57448566
111BMX0.57394839
112MAP3K10.57088069
113NME20.56874467
114GRK70.56345133
115CSNK1G20.55895472
116EPHA30.55658519
117CSNK1G10.54865152
118MAP3K60.54544892
119PRKCA0.53507593
120GRK60.52575543
121PRKACG0.51741331
122CDK30.51659511
123STK380.50644347
124CSF1R0.49895442
125DAPK30.49573021
126SRPK10.49259833
127STK240.48702550
128CAMK2G0.47144614
129BTK0.47125761
130CDK40.46774139
131CHUK0.46511112
132MAP3K70.45739204
133CSNK1A1L0.45227106
134TLK10.44654143
135DYRK1B0.43895279
136PRKD20.43666488
137MAP2K20.43614096
138SGK4940.43060483
139SGK2230.43060483
140PBK0.42384802
141ERBB20.41148258
142LYN0.41121859
143DAPK20.41086982
144YES10.40688984
145PRKCG0.40661620
146DDR20.40484076
147FGFR20.39602766
148MAP3K30.39549191
149IGF1R0.39323766
150RPS6KA50.39102216
151CDK90.38823066
152MYLK0.38695809
153PKN10.38459665
154JAK30.38417928
155CSNK2A10.37921525
156PAK40.37584149
157FER0.36394286
158NTRK30.34878603
159CAMK2D0.34683895
160MAP3K80.34131830
161PRKACA0.33682853
162RPS6KA20.30600730
163DAPK10.30286223
164PAK30.29162952

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25547918
2Renin-angiotensin system_Homo sapiens_hsa046143.58415670
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19228332
4Nitrogen metabolism_Homo sapiens_hsa009102.91675362
5Mineral absorption_Homo sapiens_hsa049782.71794791
6Arginine biosynthesis_Homo sapiens_hsa002202.69855980
7Tryptophan metabolism_Homo sapiens_hsa003802.67303337
8Complement and coagulation cascades_Homo sapiens_hsa046102.65836895
9Fatty acid degradation_Homo sapiens_hsa000712.61655629
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61539019
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59209273
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52017521
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50481327
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44183473
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.29292905
16Propanoate metabolism_Homo sapiens_hsa006402.27864578
17Peroxisome_Homo sapiens_hsa041462.27320272
18* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22778187
19Steroid hormone biosynthesis_Homo sapiens_hsa001402.15245794
20PPAR signaling pathway_Homo sapiens_hsa033202.05427350
21Chemical carcinogenesis_Homo sapiens_hsa052042.05004823
22Butanoate metabolism_Homo sapiens_hsa006502.02505431
23beta-Alanine metabolism_Homo sapiens_hsa004101.99233879
24* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.97292111
25Fatty acid metabolism_Homo sapiens_hsa012121.93530691
26Histidine metabolism_Homo sapiens_hsa003401.92562836
27Oxidative phosphorylation_Homo sapiens_hsa001901.91440751
28Retinol metabolism_Homo sapiens_hsa008301.91196874
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91040942
30Caffeine metabolism_Homo sapiens_hsa002321.89692451
31Staphylococcus aureus infection_Homo sapiens_hsa051501.88876268
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.86213959
33Protein digestion and absorption_Homo sapiens_hsa049741.73508883
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73373120
35Phenylalanine metabolism_Homo sapiens_hsa003601.61592099
36Tyrosine metabolism_Homo sapiens_hsa003501.56046931
37Fatty acid elongation_Homo sapiens_hsa000621.53369203
38Selenocompound metabolism_Homo sapiens_hsa004501.47738788
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42290727
40Starch and sucrose metabolism_Homo sapiens_hsa005001.41025844
41Parkinsons disease_Homo sapiens_hsa050121.39970610
42Sulfur metabolism_Homo sapiens_hsa009201.38749727
43ABC transporters_Homo sapiens_hsa020101.36851312
44Folate biosynthesis_Homo sapiens_hsa007901.35256125
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32798951
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31826582
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.31464591
48Pyruvate metabolism_Homo sapiens_hsa006201.30850956
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29558339
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29478790
51Sphingolipid metabolism_Homo sapiens_hsa006001.26313806
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.17873130
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17435791
54Bile secretion_Homo sapiens_hsa049761.13754461
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.12959060
56Fat digestion and absorption_Homo sapiens_hsa049751.12014937
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10815528
58Carbon metabolism_Homo sapiens_hsa012001.04461538
59Sulfur relay system_Homo sapiens_hsa041221.01842215
60Steroid biosynthesis_Homo sapiens_hsa001001.01058268
61Vitamin B6 metabolism_Homo sapiens_hsa007501.01018879
62One carbon pool by folate_Homo sapiens_hsa006701.00949081
63Collecting duct acid secretion_Homo sapiens_hsa049660.97111633
64Huntingtons disease_Homo sapiens_hsa050160.96617887
65Biosynthesis of amino acids_Homo sapiens_hsa012300.95121954
66Vitamin digestion and absorption_Homo sapiens_hsa049770.93578998
67Proteasome_Homo sapiens_hsa030500.91458132
68Alzheimers disease_Homo sapiens_hsa050100.88712894
69Arginine and proline metabolism_Homo sapiens_hsa003300.87589805
70Lysine degradation_Homo sapiens_hsa003100.86087708
71Glycerolipid metabolism_Homo sapiens_hsa005610.85128466
72Vibrio cholerae infection_Homo sapiens_hsa051100.82798619
73Ribosome_Homo sapiens_hsa030100.80790157
74Fatty acid biosynthesis_Homo sapiens_hsa000610.80625863
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.73471549
76Lysosome_Homo sapiens_hsa041420.71373810
77Glutathione metabolism_Homo sapiens_hsa004800.71336914
78Metabolic pathways_Homo sapiens_hsa011000.59024084
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54786258
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54088122
81Pentose phosphate pathway_Homo sapiens_hsa000300.52662996
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48240240
83Linoleic acid metabolism_Homo sapiens_hsa005910.42461780
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42193817
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41206769
86RNA polymerase_Homo sapiens_hsa030200.37007420
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36900190
88Synaptic vesicle cycle_Homo sapiens_hsa047210.31376839
89Galactose metabolism_Homo sapiens_hsa000520.30301853
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29553460
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.24261462
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.22808246
93Fructose and mannose metabolism_Homo sapiens_hsa000510.21281200
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20845336
95Arachidonic acid metabolism_Homo sapiens_hsa005900.19970583
96Asthma_Homo sapiens_hsa053100.19799288
97Inositol phosphate metabolism_Homo sapiens_hsa005620.18859726
98Prion diseases_Homo sapiens_hsa050200.18123892
99Insulin resistance_Homo sapiens_hsa049310.18015544
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17151718
101Cardiac muscle contraction_Homo sapiens_hsa042600.11221056
102Rheumatoid arthritis_Homo sapiens_hsa053230.06621874
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06164329
104Glucagon signaling pathway_Homo sapiens_hsa049220.06101966
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05390745
106Pyrimidine metabolism_Homo sapiens_hsa002400.05268152
107Phototransduction_Homo sapiens_hsa047440.04946097
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04375732
109AMPK signaling pathway_Homo sapiens_hsa041520.04226348
110Ovarian steroidogenesis_Homo sapiens_hsa04913-8.8939644
111Purine metabolism_Homo sapiens_hsa00230-0.1480254
112NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1466241
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1365506
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1248754
115African trypanosomiasis_Homo sapiens_hsa05143-0.1245051
116Other glycan degradation_Homo sapiens_hsa00511-0.1226061
117Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1206165
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1175756
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1113937
120Ether lipid metabolism_Homo sapiens_hsa00565-0.0873616
121Protein export_Homo sapiens_hsa03060-0.0790593
122Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0698151
123Regulation of autophagy_Homo sapiens_hsa04140-0.0652928
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0454218
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0296783
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0252363

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