DHCR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.88776862
2L-phenylalanine catabolic process (GO:0006559)6.88776862
3alpha-linolenic acid metabolic process (GO:0036109)6.77517087
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.60942376
5L-phenylalanine metabolic process (GO:0006558)6.60942376
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05364214
7aromatic amino acid family catabolic process (GO:0009074)5.92500198
8high-density lipoprotein particle remodeling (GO:0034375)5.73616425
9bile acid biosynthetic process (GO:0006699)5.63287166
10glyoxylate metabolic process (GO:0046487)5.54796194
11kynurenine metabolic process (GO:0070189)5.18600528
12sulfur amino acid catabolic process (GO:0000098)5.17923430
13tryptophan catabolic process (GO:0006569)5.12712816
14indole-containing compound catabolic process (GO:0042436)5.12712816
15indolalkylamine catabolic process (GO:0046218)5.12712816
16reverse cholesterol transport (GO:0043691)5.02933915
17urea metabolic process (GO:0019627)4.93726379
18urea cycle (GO:0000050)4.93726379
19proline biosynthetic process (GO:0006561)4.91799064
20negative regulation of fibrinolysis (GO:0051918)4.87737049
21tryptophan metabolic process (GO:0006568)4.78970801
22serine family amino acid catabolic process (GO:0009071)4.78755429
23* cholesterol biosynthetic process (GO:0006695)4.78261692
24bile acid metabolic process (GO:0008206)4.76873558
25plasma lipoprotein particle remodeling (GO:0034369)4.70509479
26protein-lipid complex remodeling (GO:0034368)4.70509479
27macromolecular complex remodeling (GO:0034367)4.70509479
28cysteine metabolic process (GO:0006534)4.69723108
29serine family amino acid biosynthetic process (GO:0009070)4.66481562
30glycine metabolic process (GO:0006544)4.65282144
31negative regulation of sterol transport (GO:0032372)4.61218787
32negative regulation of cholesterol transport (GO:0032375)4.61218787
33regulation of protein activation cascade (GO:2000257)4.60181886
34regulation of cholesterol homeostasis (GO:2000188)4.59796166
35regulation of fibrinolysis (GO:0051917)4.58976451
36linoleic acid metabolic process (GO:0043651)4.58484465
37L-serine metabolic process (GO:0006563)4.55100828
38regulation of cholesterol esterification (GO:0010872)4.51833205
39nitrogen cycle metabolic process (GO:0071941)4.51359704
40plasma lipoprotein particle clearance (GO:0034381)4.44981347
41COPI coating of Golgi vesicle (GO:0048205)4.43330801
42Golgi transport vesicle coating (GO:0048200)4.43330801
43aromatic amino acid family metabolic process (GO:0009072)4.40425671
44coenzyme catabolic process (GO:0009109)4.36546096
45tyrosine metabolic process (GO:0006570)4.32738542
46phospholipid efflux (GO:0033700)4.29695662
47protein carboxylation (GO:0018214)4.29518131
48peptidyl-glutamic acid carboxylation (GO:0017187)4.29518131
49complement activation, alternative pathway (GO:0006957)4.28504995
50fatty acid elongation (GO:0030497)4.27818502
51regulation of triglyceride catabolic process (GO:0010896)4.26017315
52regulation of complement activation (GO:0030449)4.25720798
53serine family amino acid metabolic process (GO:0009069)4.23973744
54heme transport (GO:0015886)4.23050291
55proline metabolic process (GO:0006560)4.16525765
56* sterol biosynthetic process (GO:0016126)4.15511215
57cholesterol efflux (GO:0033344)4.15021321
58ethanol oxidation (GO:0006069)4.13860073
59alpha-amino acid catabolic process (GO:1901606)4.10758052
60fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07153956
61very long-chain fatty acid metabolic process (GO:0000038)4.05442765
62acylglycerol homeostasis (GO:0055090)4.04807857
63triglyceride homeostasis (GO:0070328)4.04807857
64cellular modified amino acid catabolic process (GO:0042219)4.03511276
65amino-acid betaine metabolic process (GO:0006577)4.01579623
66benzene-containing compound metabolic process (GO:0042537)4.01279060
67homocysteine metabolic process (GO:0050667)3.99039306
68bile acid and bile salt transport (GO:0015721)3.96542666
69acetyl-CoA metabolic process (GO:0006084)3.96313547
70fatty-acyl-CoA biosynthetic process (GO:0046949)3.94692470
71plasma lipoprotein particle assembly (GO:0034377)3.92302317
72cellular ketone body metabolic process (GO:0046950)3.91151642
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.86027997
74pyrimidine nucleobase catabolic process (GO:0006208)3.84447458
75cellular amino acid catabolic process (GO:0009063)3.82305632
76very-low-density lipoprotein particle assembly (GO:0034379)3.80667680
77positive regulation of triglyceride metabolic process (GO:0090208)3.80438853
78C21-steroid hormone biosynthetic process (GO:0006700)3.80362472
79imidazole-containing compound metabolic process (GO:0052803)3.76402017
80* steroid biosynthetic process (GO:0006694)3.73085219
81low-density lipoprotein particle remodeling (GO:0034374)3.71693402
82arginine metabolic process (GO:0006525)3.70619914
83glutamate metabolic process (GO:0006536)3.68429606
84amine catabolic process (GO:0009310)3.68353863
85cellular biogenic amine catabolic process (GO:0042402)3.68353863
86lysine metabolic process (GO:0006553)3.68026434
87lysine catabolic process (GO:0006554)3.68026434
88* cholesterol metabolic process (GO:0008203)3.67493865
89glucocorticoid biosynthetic process (GO:0006704)3.66314360
90plasma lipoprotein particle organization (GO:0071827)3.65834105
91cholesterol homeostasis (GO:0042632)3.64642063
92indolalkylamine metabolic process (GO:0006586)3.62141321
93drug catabolic process (GO:0042737)3.59684940
94positive regulation of triglyceride biosynthetic process (GO:0010867)3.59281353
95* sterol metabolic process (GO:0016125)3.57895080
96acyl-CoA biosynthetic process (GO:0071616)3.57662839
97thioester biosynthetic process (GO:0035384)3.57662839
98desmosome organization (GO:0002934)3.56317984
99sterol homeostasis (GO:0055092)3.55886265
100glucose 6-phosphate metabolic process (GO:0051156)3.55429475
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54503622
102short-chain fatty acid metabolic process (GO:0046459)3.53219104
103* regulation of cholesterol biosynthetic process (GO:0045540)3.52839108
104positive regulation of lipoprotein lipase activity (GO:0051006)3.52738650
105positive regulation of triglyceride lipase activity (GO:0061365)3.52738650
106cellular glucuronidation (GO:0052695)3.51579177
107protein-lipid complex assembly (GO:0065005)3.51142462
108regulation of translational fidelity (GO:0006450)3.50683512
109intestinal cholesterol absorption (GO:0030299)3.47586438
110biotin metabolic process (GO:0006768)3.42843449
111protein retention in ER lumen (GO:0006621)3.41119661
112DNA unwinding involved in DNA replication (GO:0006268)3.37483934
113cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.27098810
114NADPH regeneration (GO:0006740)3.12784266
115peptidyl-arginine omega-N-methylation (GO:0035247)3.11185793
116glutamine family amino acid biosynthetic process (GO:0009084)3.10418578
117retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07785075
118protein maturation by protein folding (GO:0022417)3.02787318
119hemidesmosome assembly (GO:0031581)3.01703446
120glucose catabolic process (GO:0006007)2.98157828
1214-hydroxyproline metabolic process (GO:0019471)2.97066703
122pentose-phosphate shunt (GO:0006098)2.96684625
123low-density lipoprotein particle clearance (GO:0034383)2.92449122
124nuclear pore complex assembly (GO:0051292)2.86508875
125heterochromatin organization (GO:0070828)2.84996531
126response to follicle-stimulating hormone (GO:0032354)2.81510546
127mitotic chromosome condensation (GO:0007076)2.81064106
128isoprenoid biosynthetic process (GO:0008299)2.80926606
129long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.77430567
130monosaccharide biosynthetic process (GO:0046364)2.73767061
131gluconeogenesis (GO:0006094)2.67682561
132L-alpha-amino acid transmembrane transport (GO:1902475)2.67408054
133DNA strand elongation involved in DNA replication (GO:0006271)2.64973265
134regulation of mammary gland epithelial cell proliferation (GO:0033599)2.64300176
135gap junction assembly (GO:0016264)2.61925443
136positive regulation of hormone metabolic process (GO:0032352)2.61009541
137peptidyl-arginine N-methylation (GO:0035246)2.59755453
138peptidyl-arginine methylation (GO:0018216)2.59755453
139DNA strand elongation (GO:0022616)2.59673186
140histone arginine methylation (GO:0034969)2.59140401
141hexose biosynthetic process (GO:0019319)2.58089237
142negative regulation of fatty acid biosynthetic process (GO:0045717)2.54442874
143epithelial cell-cell adhesion (GO:0090136)2.53103375
144COPII vesicle coating (GO:0048208)2.50359961
145regulation of plasminogen activation (GO:0010755)2.50135524
146positive regulation of hormone biosynthetic process (GO:0046886)2.46245429
147nuclear pore organization (GO:0006999)2.44453459
148tricarboxylic acid metabolic process (GO:0072350)2.42458847
149bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42031375
150protein complex localization (GO:0031503)2.40151118
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39891991
152DNA replication initiation (GO:0006270)2.37971054
153regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.36846744
154tetrahydrofolate metabolic process (GO:0046653)2.34886238
155oxaloacetate metabolic process (GO:0006107)2.32864724
156basement membrane organization (GO:0071711)2.32817465
157regulation of bile acid biosynthetic process (GO:0070857)2.32713317
158glycolytic process (GO:0006096)2.32350544
159pentose metabolic process (GO:0019321)2.28187428
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28123689
161formation of translation preinitiation complex (GO:0001731)2.27791949
162fatty-acyl-CoA metabolic process (GO:0035337)2.27627845
163NADH metabolic process (GO:0006734)2.27426582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.63466816
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.64245211
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.89022675
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.63204371
5E2F7_22180533_ChIP-Seq_HELA_Human5.06915611
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.78056194
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.65432201
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.48021282
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67739502
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18124855
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.94597158
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.68420768
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48405330
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42950546
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.42596060
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20136181
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.11084454
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10996494
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09091585
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06856030
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2305035
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98401143
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97955648
24* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97296934
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97187923
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.89752327
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.88989838
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.88522714
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83530363
30XRN2_22483619_ChIP-Seq_HELA_Human1.81469678
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.75247918
32CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67429125
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64272025
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63537493
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63094826
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62527984
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62156737
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61461185
39ZNF263_19887448_ChIP-Seq_K562_Human1.54826021
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51702148
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51246473
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51230732
43HTT_18923047_ChIP-ChIP_STHdh_Human1.46642090
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46449490
45CLOCK_20551151_ChIP-Seq_293T_Human1.43248443
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42469330
47DCP1A_22483619_ChIP-Seq_HELA_Human1.39877581
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37320223
49LXR_22292898_ChIP-Seq_THP-1_Human1.36827086
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33212147
51MYC_22102868_ChIP-Seq_BL_Human1.30870013
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29558240
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29383198
54* GABP_19822575_ChIP-Seq_HepG2_Human1.28805579
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28759790
56* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26627316
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.26626842
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26504691
59* HNF4A_19822575_ChIP-Seq_HepG2_Human1.26299495
60ATF3_27146783_Chip-Seq_COLON_Human1.26231685
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.25241259
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.23621855
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20481642
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.17804690
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17075531
66SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16342954
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16236403
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15996418
69KDM5A_27292631_Chip-Seq_BREAST_Human1.15317435
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14533112
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11810998
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09248685
73RARA_24833708_ChIP-Seq_LIVER_Mouse1.08934923
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08595836
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07303680
76TTF2_22483619_ChIP-Seq_HELA_Human1.07271984
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06675951
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.06078031
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06068048
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05492519
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05361169
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05152079
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.04876521
84* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04530741
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04346782
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03145218
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.02578103
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01978552
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01686237
90CHD1_26751641_Chip-Seq_LNCaP_Human1.01143600
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01061829
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01032211
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00071407
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99456532
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.98739422
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97295076
97WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97257819
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94850779
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93382194
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.93068736
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92931698
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90847753
103DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90711883
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90413276
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.89951063
106* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88990021
107AR_21909140_ChIP-Seq_LNCAP_Human0.88023937
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85239944
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84013394
110RACK7_27058665_Chip-Seq_MCF-7_Human0.82940988
111STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81094113
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80577061
113P68_20966046_ChIP-Seq_HELA_Human0.79730666
114GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76625273
115GATA4_25053715_ChIP-Seq_YYC3_Human0.76388345
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76272515
117BCOR_27268052_Chip-Seq_Bcells_Human0.75687840
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74276111
119BCL6_27268052_Chip-Seq_Bcells_Human0.72275084
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72103403
121ETS1_21867929_ChIP-Seq_TH2_Mouse0.70658103
122* E2F1_20622854_ChIP-Seq_HELA_Human0.70533086
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.70017471
124CTCF_27219007_Chip-Seq_Bcells_Human0.69158793
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.68999164
126* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.68052271
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.67353844
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.66919675
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66664002
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.65801208
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.65261852
132TET1_21451524_ChIP-Seq_MESCs_Mouse0.65100933
133PHF8_20622854_ChIP-Seq_HELA_Human0.64455596
134NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.63579816
135CTCF_20526341_ChIP-Seq_ESCs_Human0.62533404
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.62380403
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.61475765
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.61191078
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.60893586
140SA1_27219007_Chip-Seq_Bcells_Human0.60505690
141TCF3_18692474_ChIP-Seq_MESCs_Mouse0.60175773
142CREB1_26743006_Chip-Seq_LNCaP_Human0.59989831
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.59973169
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.59099021
145SOX2_18692474_ChIP-Seq_MESCs_Mouse0.58916403
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.58692188
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.58347741
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.56744745
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.56432099
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.55156632
151GATA6_25053715_ChIP-Seq_YYC3_Human0.55008662
152RARG_19884340_ChIP-ChIP_MEFs_Mouse0.53903011
153EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.52921031
154POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.52727978
155MYC_18358816_ChIP-ChIP_MESCs_Mouse0.52584737
156SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52539000
157P53_21459846_ChIP-Seq_SAOS-2_Human0.52428664
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.51604323
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.51080540
160ELF1_20517297_ChIP-Seq_JURKAT_Human0.50834073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.01413960
2MP0005360_urolithiasis6.86729440
3MP0005365_abnormal_bile_salt5.83786790
4MP0005085_abnormal_gallbladder_physiolo5.76067652
5MP0003806_abnormal_nucleotide_metabolis4.78486538
6MP0008875_abnormal_xenobiotic_pharmacok4.60812296
7MP0009840_abnormal_foam_cell4.40982152
8MP0010329_abnormal_lipoprotein_level3.55870187
9MP0005083_abnormal_biliary_tract3.29441551
10MP0010234_abnormal_vibrissa_follicle3.00836338
11MP0003252_abnormal_bile_duct2.91053935
12MP0003941_abnormal_skin_development2.56685349
13MP0005332_abnormal_amino_acid2.47101585
14MP0001666_abnormal_nutrient_absorption2.39574609
15MP0003122_maternal_imprinting2.21948031
16MP0003191_abnormal_cellular_cholesterol2.21691944
17MP0003011_delayed_dark_adaptation2.21284030
18MP0003693_abnormal_embryo_hatching2.13429981
19MP0003195_calcinosis2.13130354
20MP0004272_abnormal_basement_membrane2.09964549
21MP0003868_abnormal_feces_composition2.07855319
22* MP0002118_abnormal_lipid_homeostasis2.07693200
23MP0003123_paternal_imprinting2.07326542
24MP0003566_abnormal_cell_adhesion2.00695900
25MP0004957_abnormal_blastocyst_morpholog1.99708856
26* MP0000609_abnormal_liver_physiology1.99173399
27MP0003111_abnormal_nucleus_morphology1.91758875
28MP0004264_abnormal_extraembryonic_tissu1.90617219
29MP0004019_abnormal_vitamin_homeostasis1.89099463
30MP0000537_abnormal_urethra_morphology1.88048653
31MP0005451_abnormal_body_composition1.87129848
32MP0004233_abnormal_muscle_weight1.86398516
33MP0008932_abnormal_embryonic_tissue1.80531380
34MP0001730_embryonic_growth_arrest1.71972832
35MP0005076_abnormal_cell_differentiation1.68288380
36MP0000639_abnormal_adrenal_gland1.59035831
37MP0003329_amyloid_beta_deposits1.57551552
38MP0002098_abnormal_vibrissa_morphology1.51666936
39MP0010094_abnormal_chromosome_stability1.50851320
40* MP0005319_abnormal_enzyme/_coenzyme1.45592155
41MP0001849_ear_inflammation1.42078812
42MP0000678_abnormal_parathyroid_gland1.41865130
43* MP0005584_abnormal_enzyme/coenzyme_acti1.38757147
44MP0001764_abnormal_homeostasis1.38113715
45MP0002796_impaired_skin_barrier1.36272031
46MP0003656_abnormal_erythrocyte_physiolo1.35317178
47MP0003942_abnormal_urinary_system1.32101152
48MP0003890_abnormal_embryonic-extraembry1.30854037
49MP0003077_abnormal_cell_cycle1.29418679
50MP0005647_abnormal_sex_gland1.29280930
51MP0000604_amyloidosis1.29106936
52MP0001672_abnormal_embryogenesis/_devel1.28566128
53MP0005380_embryogenesis_phenotype1.28566128
54MP0000579_abnormal_nail_morphology1.22563174
55MP0002697_abnormal_eye_size1.22496794
56MP0000762_abnormal_tongue_morphology1.22083059
57MP0003705_abnormal_hypodermis_morpholog1.20746455
58MP0005257_abnormal_intraocular_pressure1.19203641
59MP0003984_embryonic_growth_retardation1.18385997
60MP0008260_abnormal_autophagy1.17307725
61MP0003186_abnormal_redox_activity1.15783272
62* MP0002080_prenatal_lethality1.15470346
63MP0002088_abnormal_embryonic_growth/wei1.15008021
64MP0000647_abnormal_sebaceous_gland1.13750268
65MP0001697_abnormal_embryo_size1.12997243
66MP0004381_abnormal_hair_follicle1.10087019
67MP0002653_abnormal_ependyma_morphology1.06475302
68MP0002085_abnormal_embryonic_tissue1.05448050
69MP0000350_abnormal_cell_proliferation1.05444530
70MP0004858_abnormal_nervous_system1.05098279
71MP0001915_intracranial_hemorrhage1.04652995
72MP0002086_abnormal_extraembryonic_tissu1.03900447
73MP0005409_darkened_coat_color1.02466195
74MP0005058_abnormal_lysosome_morphology1.01520788
75MP0009697_abnormal_copulation1.01436296
76MP0009643_abnormal_urine_homeostasis1.00875584
77MP0000598_abnormal_liver_morphology1.00455002
78MP0002060_abnormal_skin_morphology1.00110583
79MP0002254_reproductive_system_inflammat0.99024932
80MP0004782_abnormal_surfactant_physiolog0.98403042
81MP0002084_abnormal_developmental_patter0.96553641
82MP0003937_abnormal_limbs/digits/tail_de0.94987440
83MP0000566_synostosis0.93651205
84MP0003690_abnormal_glial_cell0.93523561
85MP0009780_abnormal_chondrocyte_physiolo0.93127859
86MP0002111_abnormal_tail_morphology0.93100705
87MP0003718_maternal_effect0.91511318
88MP0005408_hypopigmentation0.91280932
89MP0001661_extended_life_span0.89832519
90* MP0004197_abnormal_fetal_growth/weight/0.87932011
91MP0005636_abnormal_mineral_homeostasis0.87079246
92MP0008007_abnormal_cellular_replicative0.85930480
93MP0003121_genomic_imprinting0.83548277
94MP0003385_abnormal_body_wall0.83385783
95MP0002822_catalepsy0.81915262
96MP0000534_abnormal_ureter_morphology0.80333858
97MP0001340_abnormal_eyelid_morphology0.79840430
98MP0009053_abnormal_anal_canal0.78874242
99MP0000003_abnormal_adipose_tissue0.78372254
100MP0010352_gastrointestinal_tract_polyps0.78248266
101MP0005623_abnormal_meninges_morphology0.77410591
102MP0010771_integument_phenotype0.76332415
103MP0000462_abnormal_digestive_system0.76147056
104MP0008438_abnormal_cutaneous_collagen0.75794547
105MP0005501_abnormal_skin_physiology0.75757392
106MP0002938_white_spotting0.74839900
107* MP0003115_abnormal_respiratory_system0.74131368
108MP0005499_abnormal_olfactory_system0.71751773
109MP0005394_taste/olfaction_phenotype0.71751773
110MP0000627_abnormal_mammary_gland0.71697794
111* MP0009642_abnormal_blood_homeostasis0.71079580
112MP0004885_abnormal_endolymph0.66513501
113MP0003315_abnormal_perineum_morphology0.66141267
114MP0009763_increased_sensitivity_to0.62779854
115* MP0009672_abnormal_birth_weight0.60759158
116MP0005220_abnormal_exocrine_pancreas0.60190098
117MP0003632_abnormal_nervous_system0.58875860
118MP0005376_homeostasis/metabolism_phenot0.58369767
119MP0005187_abnormal_penis_morphology0.57159735
120MP0009384_cardiac_valve_regurgitation0.55791233
121MP0004130_abnormal_muscle_cell0.52978284
122MP0002971_abnormal_brown_adipose0.52828109
123MP0002078_abnormal_glucose_homeostasis0.52278561
124MP0005334_abnormal_fat_pad0.51372506
125MP0002249_abnormal_larynx_morphology0.51178728
126MP0005075_abnormal_melanosome_morpholog0.50986832
127MP0002138_abnormal_hepatobiliary_system0.48562705
128MP0000377_abnormal_hair_follicle0.47302301
129MP0005670_abnormal_white_adipose0.47268511
130MP0008469_abnormal_protein_level0.46766985
131MP0009765_abnormal_xenobiotic_induced0.46737184
132MP0001324_abnormal_eye_pigmentation0.46682592
133MP0005266_abnormal_metabolism0.46431652
134MP0000467_abnormal_esophagus_morphology0.46104270
135MP0002092_abnormal_eye_morphology0.45364148
136MP0004947_skin_inflammation0.43816529
137MP0005448_abnormal_energy_balance0.43292957
138MP0005377_hearing/vestibular/ear_phenot0.43222806
139MP0003878_abnormal_ear_physiology0.43222806
140MP0004185_abnormal_adipocyte_glucose0.42840183
141MP0005395_other_phenotype0.42244855
142* MP0003953_abnormal_hormone_level0.40027149
143MP0008961_abnormal_basal_metabolism0.39930907
144MP0000372_irregular_coat_pigmentation0.39856674
145MP0010678_abnormal_skin_adnexa0.39629782
146MP0003699_abnormal_female_reproductive0.39102457
147MP0008872_abnormal_physiological_respon0.38985489
148MP0003638_abnormal_response/metabolism_0.38328264
149MP0001756_abnormal_urination0.37310701
150MP0010030_abnormal_orbit_morphology0.37020861
151MP0004883_abnormal_blood_vessel0.37004878
152MP0009764_decreased_sensitivity_to0.36839465
153MP0002089_abnormal_postnatal_growth/wei0.35814450
154MP0002970_abnormal_white_adipose0.35246729
155MP0001243_abnormal_dermal_layer0.34593433
156MP0000383_abnormal_hair_follicle0.34077707
157MP0000920_abnormal_myelination0.33879549
158MP0005666_abnormal_adipose_tissue0.33766349
159MP0003453_abnormal_keratinocyte_physiol0.32116664
160MP0001216_abnormal_epidermal_layer0.31254347

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.42687327
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.01275868
3Deep venous thrombosis (HP:0002625)6.73504665
4Xanthomatosis (HP:0000991)6.41667251
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34427763
6Hypobetalipoproteinemia (HP:0003563)6.06711325
7Hyperlipoproteinemia (HP:0010980)5.57362452
8Prolonged partial thromboplastin time (HP:0003645)5.49647293
9Epidermoid cyst (HP:0200040)5.02238924
10Hypolipoproteinemia (HP:0010981)4.60355677
11Complement deficiency (HP:0004431)4.39284261
12Hyperglycinemia (HP:0002154)4.36983898
13Hyperammonemia (HP:0001987)4.33299798
14Abnormality of sulfur amino acid metabolism (HP:0004339)4.13841281
15Abnormality of methionine metabolism (HP:0010901)4.10309259
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.05033494
17Abnormality of serine family amino acid metabolism (HP:0010894)4.03042781
18Abnormality of glycine metabolism (HP:0010895)4.03042781
19Hypoalphalipoproteinemia (HP:0003233)3.99542802
20Fat malabsorption (HP:0002630)3.84765868
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.73558685
22Hyperglycinuria (HP:0003108)3.67094100
23Joint hemorrhage (HP:0005261)3.52399168
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.51303113
25Ketosis (HP:0001946)3.48963256
26Abnormality of pyrimidine metabolism (HP:0004353)3.45681433
27Abnormality of the common coagulation pathway (HP:0010990)3.34292469
28Neonatal onset (HP:0003623)3.22469038
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21377891
30Hypercholesterolemia (HP:0003124)3.08148989
31Steatorrhea (HP:0002570)3.00400956
32Acanthocytosis (HP:0001927)2.98645512
33Hyperbilirubinemia (HP:0002904)2.97465701
34Abnormality of complement system (HP:0005339)2.96204527
35Delayed CNS myelination (HP:0002188)2.89085700
36Abnormality of the intrinsic pathway (HP:0010989)2.86594779
37Abnormality of serum amino acid levels (HP:0003112)2.82505030
38Pseudobulbar signs (HP:0002200)2.79983885
39Hypoglycemic coma (HP:0001325)2.76971601
40Sensorimotor neuropathy (HP:0007141)2.76530710
41Spastic paraparesis (HP:0002313)2.71903935
42Abnormal gallbladder physiology (HP:0012438)2.70715333
43Cholecystitis (HP:0001082)2.70715333
44Abnormality of fatty-acid metabolism (HP:0004359)2.69605961
45Irritability (HP:0000737)2.68978864
46Conjugated hyperbilirubinemia (HP:0002908)2.67448643
47Increased serum pyruvate (HP:0003542)2.66548289
48Abnormality of glycolysis (HP:0004366)2.66548289
49Reticulocytosis (HP:0001923)2.64346495
50Abnormality of carpal bone ossification (HP:0006257)2.59404344
51Pterygium (HP:0001059)2.57489429
52Spontaneous abortion (HP:0005268)2.56959151
53Spastic diplegia (HP:0001264)2.52474921
54Dicarboxylic aciduria (HP:0003215)2.47676986
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47676986
56Myocardial infarction (HP:0001658)2.44900303
57Hyperacusis (HP:0010780)2.44303165
58Neurofibrillary tangles (HP:0002185)2.40607485
59Skin nodule (HP:0200036)2.39777638
60Abnormality of nucleobase metabolism (HP:0010932)2.38342992
61Hepatocellular carcinoma (HP:0001402)2.37686201
62Abnormal gallbladder morphology (HP:0012437)2.36074581
63Paraparesis (HP:0002385)2.30921395
64Brushfield spots (HP:0001088)2.30080998
65Asymmetry of the thorax (HP:0001555)2.30058683
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.29085345
67Hypochromic microcytic anemia (HP:0004840)2.28119758
68Flat acetabular roof (HP:0003180)2.25609393
69Abnormal tarsal ossification (HP:0008369)2.23981962
70Pili torti (HP:0003777)2.21275013
71Lethargy (HP:0001254)2.19262868
72Right ventricular cardiomyopathy (HP:0011663)2.18607978
73Amyloidosis (HP:0011034)2.16698443
74Cerebral inclusion bodies (HP:0100314)2.16327695
75Fragile nails (HP:0001808)2.15012593
76Ulnar bowing (HP:0003031)2.14951940
77Ketoacidosis (HP:0001993)2.13401564
78Rickets (HP:0002748)2.12954027
79Cholelithiasis (HP:0001081)2.11683915
80Vascular calcification (HP:0004934)2.10687235
81Metabolic acidosis (HP:0001942)2.10626422
82Abnormal ossification of hand bones (HP:0005921)2.08144747
83Distal upper limb amyotrophy (HP:0007149)2.05972171
84Upper limb amyotrophy (HP:0009129)2.05972171
85Back pain (HP:0003418)2.05111301
86Morphological abnormality of the pyramidal tract (HP:0002062)2.01986397
87Late onset (HP:0003584)2.00239446
88Abnormality of reticulocytes (HP:0004312)1.97681970
89Abnormal hair laboratory examination (HP:0003328)1.97363188
90Onycholysis (HP:0001806)1.96570826
91Gout (HP:0001997)1.96471174
92Polycythemia (HP:0001901)1.96228607
93Hand muscle atrophy (HP:0009130)1.96087720
94Hypophosphatemic rickets (HP:0004912)1.94769430
95Turricephaly (HP:0000262)1.94564974
96Insomnia (HP:0100785)1.93973076
97Premature rupture of membranes (HP:0001788)1.93696593
98* Abnormality of the gallbladder (HP:0005264)1.92873409
99Selective tooth agenesis (HP:0001592)1.92188352
100Opisthotonus (HP:0002179)1.91066510
101Abnormality of vitamin metabolism (HP:0100508)1.90762084
102Hemorrhage of the eye (HP:0011885)1.87318237
103Bronchomalacia (HP:0002780)1.87107537
104Spastic tetraparesis (HP:0001285)1.85435372
105Abnormality of purine metabolism (HP:0004352)1.84673771
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82779158
107Absent epiphyses (HP:0010577)1.82779158
108Impaired pain sensation (HP:0007328)1.81412696
109Abnormality of pain sensation (HP:0010832)1.81412696
110Esophageal varix (HP:0002040)1.80870692
111Achilles tendon contracture (HP:0001771)1.78411913
112Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78101592
113Vertebral hypoplasia (HP:0008417)1.78101592
114Cardiovascular calcification (HP:0011915)1.75269101
115Abnormality of the Achilles tendon (HP:0005109)1.73928672
116Malnutrition (HP:0004395)1.73762098
117Abnormal hand bone ossification (HP:0010660)1.73712540
118Myelomeningocele (HP:0002475)1.72821648
119Confusion (HP:0001289)1.72569142
120Neonatal death (HP:0003811)1.72405913
121Abnormal foot bone ossification (HP:0010675)1.71767865
122Coronal craniosynostosis (HP:0004440)1.71710397
123Hypoglycemic seizures (HP:0002173)1.71325125
124Small epiphyses (HP:0010585)1.71053276
125Abnormality of nail color (HP:0100643)1.70982324
126* Deviation of the thumb (HP:0009603)1.70887700
127Mitral stenosis (HP:0001718)1.70803563
128Glomerulonephritis (HP:0000099)1.70419246
129Abnormal enzyme/coenzyme activity (HP:0012379)1.70132019
130Poikilocytosis (HP:0004447)1.69855316
131Hypoplastic pelvis (HP:0008839)1.69455004
132Arnold-Chiari malformation (HP:0002308)1.69342421
133Abnormal cartilage morphology (HP:0002763)1.69025944
134Long palpebral fissure (HP:0000637)1.67845441
135Cortical dysplasia (HP:0002539)1.67128700
136Delayed myelination (HP:0012448)1.66320726
137Choanal stenosis (HP:0000452)1.66174901
138Trismus (HP:0000211)1.66046764
139Gingival bleeding (HP:0000225)1.65861460
140Short nail (HP:0001799)1.64782772
141Renal duplication (HP:0000075)1.64638814
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63835313
143Sparse eyelashes (HP:0000653)1.63479383
144* Increased nuchal translucency (HP:0010880)1.63467207
145Abnormality of transition element cation homeostasis (HP:0011030)1.62480096
146Enlarged kidneys (HP:0000105)1.62126355
14711 pairs of ribs (HP:0000878)1.61798305
148Absent eyelashes (HP:0000561)1.61758156
149Congenital ichthyosiform erythroderma (HP:0007431)1.60662343
150Clitoromegaly (HP:0000057)1.60566098
151Thrombophlebitis (HP:0004418)1.59696093
152Vaginal fistula (HP:0004320)1.59595969
153Abnormalities of placenta or umbilical cord (HP:0001194)1.58175718
154Multiple enchondromatosis (HP:0005701)1.58107232
155Aplasia involving bones of the upper limbs (HP:0009823)1.57976001
156Aplasia of the phalanges of the hand (HP:0009802)1.57976001
157Aplasia involving bones of the extremities (HP:0009825)1.57976001
158Hypokinesia (HP:0002375)1.54028481
159Premature skin wrinkling (HP:0100678)1.52578671
160Patellar dislocation (HP:0002999)1.51507471
161Disproportionate tall stature (HP:0001519)1.51177699
162* Proximal placement of thumb (HP:0009623)1.50638255
163Hepatoblastoma (HP:0002884)1.49757153
164Ankyloglossia (HP:0010296)1.48097266
165Overriding aorta (HP:0002623)1.47829056
166Microvesicular hepatic steatosis (HP:0001414)1.47254045
167Abnormality of the umbilical cord (HP:0010881)1.46339779
168Chromsome breakage (HP:0040012)1.45744913
169J-shaped sella turcica (HP:0002680)1.45639926
170Cervical subluxation (HP:0003308)1.44657109
171Seborrheic dermatitis (HP:0001051)1.43319482
172Abnormality of the gastric mucosa (HP:0004295)1.42767627
173Abnormality of the lacrimal duct (HP:0011481)1.42264581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.61785570
2BCKDK4.12579020
3ERN14.02631393
4FGFR43.43843617
5SMG13.42488561
6TESK23.31921930
7FLT32.90242657
8TRIB32.54998679
9FGFR22.44663521
10ERBB42.43505311
11IRAK32.22266665
12DYRK22.12398299
13MARK12.03352595
14GRK62.00210903
15PKN21.95505756
16LATS21.87470483
17TBK11.83148686
18EEF2K1.73463227
19ICK1.73180552
20PAK41.71059443
21VRK21.70026247
22TSSK61.62992513
23MET1.62554079
24PBK1.58557030
25ARAF1.58135231
26NME21.57825671
27RPS6KB21.49447856
28MAPK111.47969545
29SCYL21.47078768
30SRPK11.46634953
31EPHB11.41713186
32MST1R1.36908284
33CDC71.36239401
34LATS11.36189603
35KSR21.31490085
36MAP3K101.25727700
37TESK11.25491808
38ERBB21.22799267
39CSNK1G31.16054795
40CSF1R1.15831102
41LIMK11.15660585
42PDGFRA1.14410666
43TYRO31.12095607
44PKN11.11618467
45BUB11.08358823
46RIPK11.07040736
47NEK11.05198667
48CSNK1A1L1.04847616
49MAP3K91.04707850
50PIM21.04314795
51CSNK1G21.03931864
52NTRK11.01547503
53FGFR10.98585339
54PRKD30.97525413
55CSNK1G10.95422328
56CDK70.95398326
57PTK20.95316665
58PASK0.93481944
59PHKG20.92142036
60PHKG10.92142036
61PRKCZ0.89342060
62CAMK1D0.87687882
63BRAF0.85875390
64NTRK20.85071524
65MTOR0.84455247
66TAOK30.84127341
67KDR0.83886735
68CDK120.83881311
69ABL20.82026903
70PRKCI0.81292317
71CHEK20.80498505
72WEE10.76852405
73NME10.74084304
74TAOK10.73038817
75CAMK1G0.69188626
76CDK80.68902524
77EPHA30.68730528
78MAPKAPK30.68069594
79MAP2K40.67179817
80CHEK10.66520612
81TTK0.66508829
82PLK10.66214917
83PRKACG0.66029155
84PTK60.64644437
85MARK20.64371253
86AURKB0.63474701
87MAP2K20.62434091
88PRPF4B0.61491827
89EPHB20.61115614
90MAPK120.59423020
91EPHA20.58621680
92PAK30.58344064
93MAP3K70.57969438
94RET0.57952750
95AURKA0.57352341
96TAOK20.57209732
97PDPK10.56467462
98ATR0.55281639
99TAF10.53846844
100ILK0.53243476
101STK390.52690092
102MAPK40.51846873
103PLK30.51707254
104CAMK2G0.50738098
105PAK60.50734236
106CDK10.50582497
107RAF10.50216420
108IKBKE0.48951808
109CSNK1D0.48877018
110CAMKK10.48133563
111CLK10.47818544
112GSK3A0.47030547
113PRKAA10.45873403
114CDK180.45771034
115PRKAA20.45287710
116CDK11A0.44408885
117FER0.44034415
118EIF2AK10.43873248
119BMX0.43848948
120BRSK10.43837221
121IGF1R0.43102989
122MAP3K20.41977406
123CDK40.41501150
124KSR10.41243287
125PRKCG0.40996821
126AKT20.40599305
127CDK90.40404647
128CDK20.40112075
129CSNK1E0.39461659
130EIF2AK30.38513607
131MAP3K80.38353556
132MAPKAPK50.37827513
133DAPK10.37448452
134MUSK0.37122461
135EIF2AK20.37015314
136PRKD10.36493411
137PAK20.35080550
138RPS6KA40.33916957
139ACVR1B0.33847777
140CDK140.32837316
141MAP2K60.32506363
142MAPK30.32097790
143CDK150.31602669
144NEK20.30174104
145KIT0.28818549
146UHMK10.28537879
147LMTK20.28497406
148AKT30.27803397
149MAP2K10.26490066

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82421769
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.49900215
3Nitrogen metabolism_Homo sapiens_hsa009103.40352912
4* Steroid biosynthesis_Homo sapiens_hsa001003.40104493
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92390900
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76879601
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.61522217
8Arginine biosynthesis_Homo sapiens_hsa002202.56093670
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55195209
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48206751
11Tryptophan metabolism_Homo sapiens_hsa003802.46047783
12Fatty acid degradation_Homo sapiens_hsa000712.39970333
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.33294347
14Butanoate metabolism_Homo sapiens_hsa006502.33111156
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32498850
16Fatty acid metabolism_Homo sapiens_hsa012122.27607241
17Complement and coagulation cascades_Homo sapiens_hsa046102.10545818
18Fatty acid elongation_Homo sapiens_hsa000621.97365907
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87102900
20DNA replication_Homo sapiens_hsa030301.85808758
21Histidine metabolism_Homo sapiens_hsa003401.80373661
22Propanoate metabolism_Homo sapiens_hsa006401.79658754
23Peroxisome_Homo sapiens_hsa041461.77278726
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76242630
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72838439
26PPAR signaling pathway_Homo sapiens_hsa033201.68819578
27Chemical carcinogenesis_Homo sapiens_hsa052041.63156104
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61496779
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57729471
30Biosynthesis of amino acids_Homo sapiens_hsa012301.55535913
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55140848
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54661894
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.54178148
34Bile secretion_Homo sapiens_hsa049761.52026201
35Pyruvate metabolism_Homo sapiens_hsa006201.50258397
36Vitamin B6 metabolism_Homo sapiens_hsa007501.49786813
37Selenocompound metabolism_Homo sapiens_hsa004501.46859181
38Sulfur metabolism_Homo sapiens_hsa009201.44783470
39Retinol metabolism_Homo sapiens_hsa008301.44694073
40Fat digestion and absorption_Homo sapiens_hsa049751.41795903
41beta-Alanine metabolism_Homo sapiens_hsa004101.40255059
42Folate biosynthesis_Homo sapiens_hsa007901.38595894
43Tyrosine metabolism_Homo sapiens_hsa003501.34961379
44Caffeine metabolism_Homo sapiens_hsa002321.32983702
45Carbon metabolism_Homo sapiens_hsa012001.30073195
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.29833468
47Fatty acid biosynthesis_Homo sapiens_hsa000611.26992361
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.25274329
49Pentose phosphate pathway_Homo sapiens_hsa000301.22246087
50Base excision repair_Homo sapiens_hsa034101.21188852
51Sulfur relay system_Homo sapiens_hsa041221.20922967
52Phenylalanine metabolism_Homo sapiens_hsa003601.19735558
53Staphylococcus aureus infection_Homo sapiens_hsa051501.13544727
54Mismatch repair_Homo sapiens_hsa034301.12259001
55Arginine and proline metabolism_Homo sapiens_hsa003301.10706491
56Vitamin digestion and absorption_Homo sapiens_hsa049771.06942613
57One carbon pool by folate_Homo sapiens_hsa006701.02063720
58ABC transporters_Homo sapiens_hsa020101.00573323
59Thyroid cancer_Homo sapiens_hsa052160.99505962
60Starch and sucrose metabolism_Homo sapiens_hsa005000.90986987
61Cell cycle_Homo sapiens_hsa041100.85542698
62RNA transport_Homo sapiens_hsa030130.84528318
63Lysine degradation_Homo sapiens_hsa003100.82533129
64Spliceosome_Homo sapiens_hsa030400.80849100
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80332745
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.78643773
67Glycerolipid metabolism_Homo sapiens_hsa005610.74995857
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74733618
69Nucleotide excision repair_Homo sapiens_hsa034200.73607982
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73079793
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69797564
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69468301
73Glutathione metabolism_Homo sapiens_hsa004800.66707093
74Vibrio cholerae infection_Homo sapiens_hsa051100.65168131
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63578569
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63155073
77Proteasome_Homo sapiens_hsa030500.59305198
78mRNA surveillance pathway_Homo sapiens_hsa030150.58944552
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52202400
80Adherens junction_Homo sapiens_hsa045200.52071044
81* Metabolic pathways_Homo sapiens_hsa011000.51583759
82Hippo signaling pathway_Homo sapiens_hsa043900.49484645
83Other glycan degradation_Homo sapiens_hsa005110.47910250
84ECM-receptor interaction_Homo sapiens_hsa045120.47719644
85Endometrial cancer_Homo sapiens_hsa052130.46039522
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44785782
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.42101079
88Ovarian steroidogenesis_Homo sapiens_hsa049130.39037163
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37974856
90Fructose and mannose metabolism_Homo sapiens_hsa000510.37764555
91Linoleic acid metabolism_Homo sapiens_hsa005910.36996735
92Chronic myeloid leukemia_Homo sapiens_hsa052200.36799306
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35098767
94Tight junction_Homo sapiens_hsa045300.34686882
95Small cell lung cancer_Homo sapiens_hsa052220.34327838
96MicroRNAs in cancer_Homo sapiens_hsa052060.30763237
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29653026
98Non-homologous end-joining_Homo sapiens_hsa034500.27963843
99Prion diseases_Homo sapiens_hsa050200.27888824
100RNA polymerase_Homo sapiens_hsa030200.27005613
101Galactose metabolism_Homo sapiens_hsa000520.24289439
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18360089
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12629310
104Ether lipid metabolism_Homo sapiens_hsa005650.12432637
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10301744
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.09625578
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.07568456
108AMPK signaling pathway_Homo sapiens_hsa041520.06731219
109Insulin resistance_Homo sapiens_hsa049310.01800357
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2296426
111Axon guidance_Homo sapiens_hsa04360-0.2169762
112Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1939263
113Renin-angiotensin system_Homo sapiens_hsa04614-0.1733333
114Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1550142
115Pyrimidine metabolism_Homo sapiens_hsa00240-0.1534372
116N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1422466
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1262974
118Insulin signaling pathway_Homo sapiens_hsa04910-0.1224932
119Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1197931
120Glucagon signaling pathway_Homo sapiens_hsa04922-0.0998558
121Bladder cancer_Homo sapiens_hsa05219-0.0974399
122Hepatitis C_Homo sapiens_hsa05160-0.0933834
123Mineral absorption_Homo sapiens_hsa04978-0.0835435
124Basal cell carcinoma_Homo sapiens_hsa05217-0.0752108
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0170370
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0102585

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