DGAT2L6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the diacylglycerol acyltransferase 2 family. The encoded protein is a putative acyltransferase and is most likely involved in the synthesis of di- or triacylglycerol, however its substrate specificity is currently unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.94805929
2hair follicle morphogenesis (GO:0031069)9.03073663
3linoleic acid metabolic process (GO:0043651)8.80393643
4intermediate filament cytoskeleton organization (GO:0045104)8.20669011
5intermediate filament-based process (GO:0045103)7.95813889
6long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)7.39320783
7long-chain fatty-acyl-CoA metabolic process (GO:0035336)7.13666838
8peptide cross-linking (GO:0018149)7.02608663
9very long-chain fatty acid metabolic process (GO:0000038)6.85525927
10keratinocyte proliferation (GO:0043616)6.76518404
11epidermis development (GO:0008544)6.74037832
12fatty-acyl-CoA biosynthetic process (GO:0046949)6.61984504
13multicellular organismal water homeostasis (GO:0050891)6.57377644
14keratinocyte differentiation (GO:0030216)6.45545635
15central nervous system myelination (GO:0022010)5.86752736
16axon ensheathment in central nervous system (GO:0032291)5.86752736
17fatty-acyl-CoA metabolic process (GO:0035337)5.64453288
18retinol metabolic process (GO:0042572)5.62635910
19thioester biosynthetic process (GO:0035384)5.44597414
20acyl-CoA biosynthetic process (GO:0071616)5.44597414
21hair cycle process (GO:0022405)5.43991580
22molting cycle process (GO:0022404)5.43991580
23water homeostasis (GO:0030104)5.41685109
24epidermal cell differentiation (GO:0009913)5.32503576
25presynaptic membrane assembly (GO:0097105)5.12360244
26positive regulation of chemokine secretion (GO:0090197)5.05959883
27alpha-linolenic acid metabolic process (GO:0036109)4.90861825
28positive regulation of keratinocyte differentiation (GO:0045618)4.89584863
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.73881464
30presynaptic membrane organization (GO:0097090)4.73072331
31neuron cell-cell adhesion (GO:0007158)4.57354837
32regulation of chemokine secretion (GO:0090196)4.55696505
33limb bud formation (GO:0060174)4.45212182
34long-chain fatty acid biosynthetic process (GO:0042759)4.43603453
35lipoxygenase pathway (GO:0019372)4.38340807
36hemidesmosome assembly (GO:0031581)4.37624078
37primary alcohol metabolic process (GO:0034308)4.21043021
38cerebral cortex radially oriented cell migration (GO:0021799)4.12638761
39phosphatidylserine acyl-chain remodeling (GO:0036150)3.99739358
40phosphatidylinositol acyl-chain remodeling (GO:0036149)3.95666191
41triglyceride biosynthetic process (GO:0019432)3.95438831
42regulation of sequestering of triglyceride (GO:0010889)3.85206763
43postsynaptic membrane organization (GO:0001941)3.79230003
44positive regulation of epidermal cell differentiation (GO:0045606)3.78965027
45neutral lipid biosynthetic process (GO:0046460)3.73362684
46acylglycerol biosynthetic process (GO:0046463)3.73362684
47fatty acid elongation (GO:0030497)3.71474910
48regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.59069159
49regulation of keratinocyte differentiation (GO:0045616)3.50946932
50L-amino acid import (GO:0043092)3.50044333
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48802526
52negative regulation of neurotransmitter transport (GO:0051589)3.47337075
53carnitine metabolic process (GO:0009437)3.43543548
54keratinocyte development (GO:0003334)3.32132913
55response to phenylpropanoid (GO:0080184)3.31525658
56startle response (GO:0001964)3.30136564
57oligodendrocyte differentiation (GO:0048709)3.26411805
58skin morphogenesis (GO:0043589)3.26225397
59epithelium development (GO:0060429)3.25878491
60thioester metabolic process (GO:0035383)3.24574894
61acyl-CoA metabolic process (GO:0006637)3.24574894
62defense response to fungus (GO:0050832)3.23318092
63neuronal action potential propagation (GO:0019227)3.21927230
64myelination (GO:0042552)3.21047528
65epithelial cell differentiation involved in prostate gland development (GO:0060742)3.20833712
66primary alcohol catabolic process (GO:0034310)3.20801023
67fibrinolysis (GO:0042730)3.20050753
68negative regulation of execution phase of apoptosis (GO:1900118)3.18063535
69regulation of timing of cell differentiation (GO:0048505)3.17327982
70negative regulation of neurotransmitter secretion (GO:0046929)3.15844512
71regulation of defense response to virus by host (GO:0050691)3.15629252
72positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.14444684
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.14108862
74retina layer formation (GO:0010842)3.13968339
75negative regulation of protein localization to cell surface (GO:2000009)3.13706788
76glutamate receptor signaling pathway (GO:0007215)3.12905111
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12864236
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.12371121
79axon ensheathment (GO:0008366)3.12199492
80ensheathment of neurons (GO:0007272)3.12199492
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09727651
82positive regulation of synapse assembly (GO:0051965)3.08968256
83positive regulation of epidermis development (GO:0045684)3.07884130
84photoreceptor cell differentiation (GO:0046530)3.07072224
85eye photoreceptor cell differentiation (GO:0001754)3.07072224
86transmission of nerve impulse (GO:0019226)3.03578571
87positive regulation of action potential (GO:0045760)3.03082833
88neuron recognition (GO:0008038)3.02260534
89amino acid import (GO:0043090)3.01305044
90righting reflex (GO:0060013)3.01156780
91hair cycle (GO:0042633)25.6873041
92molting cycle (GO:0042303)25.6873041
93virion attachment to host cell (GO:0019062)2.98406308
94adhesion of symbiont to host cell (GO:0044650)2.98406308
95phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.97433172
96killing of cells of other organism (GO:0031640)2.97299252
97disruption of cells of other organism (GO:0044364)2.97299252
98neuron remodeling (GO:0016322)2.97126257
99phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.90211472
100regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.86827445
101negative regulation of keratinocyte proliferation (GO:0010839)2.84568668
102unsaturated fatty acid biosynthetic process (GO:0006636)2.84090158
103one-carbon compound transport (GO:0019755)2.82999464
104glycerophospholipid catabolic process (GO:0046475)2.82808331
105vocalization behavior (GO:0071625)2.79405484
106regulation of pigment cell differentiation (GO:0050932)2.76811628
107regulation of phospholipase A2 activity (GO:0032429)2.76027705
108hair follicle development (GO:0001942)2.75066991
109phosphatidylcholine acyl-chain remodeling (GO:0036151)2.74993000
110import into cell (GO:0098657)2.74760302
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73719662
112nonmotile primary cilium assembly (GO:0035058)2.73654034
113cranial nerve morphogenesis (GO:0021602)2.68145689
114fatty acid biosynthetic process (GO:0006633)2.66932875
115protein localization to synapse (GO:0035418)2.65972199
116cerebral cortex cell migration (GO:0021795)2.65695468
117sympathetic nervous system development (GO:0048485)2.62160678
118forebrain neuron differentiation (GO:0021879)2.61689058
119organ growth (GO:0035265)2.60684028
120developmental pigmentation (GO:0048066)2.60577128
121adhesion of symbiont to host (GO:0044406)2.59746102
122regulation of collateral sprouting (GO:0048670)2.58912720
123serotonin receptor signaling pathway (GO:0007210)2.58290338
124regulation of development, heterochronic (GO:0040034)2.58166903
125neuron-neuron synaptic transmission (GO:0007270)2.58016195
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57026994
127positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.56205592
128regulation of epidermal cell differentiation (GO:0045604)2.55858778
129mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55276769
130mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55276769
131response to redox state (GO:0051775)2.55276724
132reflex (GO:0060004)2.53831312
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.53075288
134phosphatidylserine metabolic process (GO:0006658)2.52053913
135axonal fasciculation (GO:0007413)2.51544544
136central nervous system projection neuron axonogenesis (GO:0021952)2.51442008
137regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51076058
138ethanol metabolic process (GO:0006067)2.50104780
139regulation of respiratory system process (GO:0044065)2.49852996
140positive regulation of meiosis (GO:0045836)2.47789836
141positive regulation of meiotic cell cycle (GO:0051446)2.47774951
142cornea development in camera-type eye (GO:0061303)2.47493661
143synaptic transmission, glutamatergic (GO:0035249)2.45998067
144negative regulation of myoblast differentiation (GO:0045662)2.45882997
145lateral sprouting from an epithelium (GO:0060601)2.45599774
146regulation of feeding behavior (GO:0060259)2.45428932
147positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.45030916
148regulation of inositol phosphate biosynthetic process (GO:0010919)2.43910394
149gamma-aminobutyric acid transport (GO:0015812)2.42720634
150cyclic nucleotide catabolic process (GO:0009214)2.40422046
151regulation of synapse assembly (GO:0051963)2.39498272
152GPI anchor metabolic process (GO:0006505)2.38624568
153regulation of glutamate secretion (GO:0014048)2.38580460
154cranial nerve development (GO:0021545)2.37819474
155short-term memory (GO:0007614)2.37245977
156regulation of respiratory gaseous exchange (GO:0043576)2.37159655
157neurotransmitter uptake (GO:0001504)2.36716412
158dendrite development (GO:0016358)2.35115293
159central nervous system neuron axonogenesis (GO:0021955)2.35081787
160GPI anchor biosynthetic process (GO:0006506)2.34402701
161positive regulation of uterine smooth muscle contraction (GO:0070474)2.33398351
162dendritic spine morphogenesis (GO:0060997)2.31859772
163adult feeding behavior (GO:0008343)2.30973231
164polarized epithelial cell differentiation (GO:0030859)2.30378411
165photoreceptor cell maintenance (GO:0045494)2.28800384
166isoprenoid biosynthetic process (GO:0008299)2.28595439
167polyol transport (GO:0015791)2.28565923
168negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.28341217
169cilium movement (GO:0003341)2.27680024
170neurotransmitter-gated ion channel clustering (GO:0072578)2.27677421
171kidney morphogenesis (GO:0060993)2.27306343
172positive regulation of amino acid transport (GO:0051957)2.27144342
173cellular response to epinephrine stimulus (GO:0071872)2.26412806
174phosphatidic acid metabolic process (GO:0046473)2.25842515
175phosphatidic acid biosynthetic process (GO:0006654)2.25842515
176detection of bacterium (GO:0016045)2.23563743
177amino-acid betaine metabolic process (GO:0006577)2.22546128
178ectoderm development (GO:0007398)2.17950580
179regulation of epidermis development (GO:0045682)2.15088857
180regulation of keratinocyte proliferation (GO:0010837)2.12241919
181alditol phosphate metabolic process (GO:0052646)2.12106520
182skin development (GO:0043588)2.11485985
183detection of other organism (GO:0098543)2.04738466
184response to fungus (GO:0009620)2.04368224
185establishment of planar polarity (GO:0001736)2.04208631
186establishment of tissue polarity (GO:0007164)2.04208631
187cellular response to antibiotic (GO:0071236)2.03798103
188lipid storage (GO:0019915)2.00086119
189intermediate filament organization (GO:0045109)13.4583534
190keratinization (GO:0031424)12.0444110
191establishment of skin barrier (GO:0061436)11.6101335
192desmosome organization (GO:0002934)10.4527072
193ventricular cardiac muscle cell action potential (GO:0086005)1.96685346
194triglyceride metabolic process (GO:0006641)1.96526815
195hair cell differentiation (GO:0035315)1.94695021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.68795213
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.60355892
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.57899811
4EZH2_22144423_ChIP-Seq_EOC_Human4.33401337
5GBX2_23144817_ChIP-Seq_PC3_Human3.84917941
6P63_26484246_Chip-Seq_KERATINOCYTES_Human3.46089814
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.14923237
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73565033
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60452489
10SOX9_24532713_ChIP-Seq_HFSC_Mouse2.59698895
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.57060744
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52188818
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.51922081
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50263400
15TAF15_26573619_Chip-Seq_HEK293_Human2.48627011
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.39684771
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39243899
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34066345
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33995524
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27142083
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26483778
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24941412
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24941412
24VDR_22108803_ChIP-Seq_LS180_Human2.23111625
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21804167
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20140347
27TP63_17297297_ChIP-ChIP_HaCaT_Human10.7766746
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94849647
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.94492076
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.93496821
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.89203844
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89203680
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88527712
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88512939
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87478042
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84117296
37P300_19829295_ChIP-Seq_ESCs_Human1.83288346
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81747883
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80303367
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79930808
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77756890
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77385552
43AR_21572438_ChIP-Seq_LNCaP_Human1.75470897
44TP63_23658742_ChIP-Seq_EP156T_Human1.75279511
45ZNF263_19887448_ChIP-Seq_K562_Human1.71398194
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.71245992
47TP63_22573176_ChIP-Seq_HFKS_Human1.69358445
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66390148
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63227097
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.63090311
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.61720730
52FUS_26573619_Chip-Seq_HEK293_Human1.60063899
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.58278335
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.56224299
55RXR_22108803_ChIP-Seq_LS180_Human1.54838040
56ERG_20517297_ChIP-Seq_VCAP_Human1.53566322
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53057599
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50589626
59ER_23166858_ChIP-Seq_MCF-7_Human1.50434854
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50157693
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48036525
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.47366766
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47184006
64IGF1R_20145208_ChIP-Seq_DFB_Human1.47169958
65REST_21632747_ChIP-Seq_MESCs_Mouse1.45791228
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45299017
67SMAD4_21799915_ChIP-Seq_A2780_Human1.43667119
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43318730
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42544361
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42086982
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42086982
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38915295
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36844830
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36142521
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.36080492
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35739489
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35385376
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35365389
79SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32624807
80GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.32163471
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.31935417
82BCOR_27268052_Chip-Seq_Bcells_Human1.31567721
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31321729
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.30420665
85P53_22387025_ChIP-Seq_ESCs_Mouse1.30375842
86* CTCF_20526341_ChIP-Seq_ESCs_Human1.29541498
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29273719
88ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26145918
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.25674755
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24953202
91BCL6_27268052_Chip-Seq_Bcells_Human1.24203299
92LXR_22292898_ChIP-Seq_THP-1_Human1.23978999
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23402508
94P300_18555785_Chip-Seq_ESCs_Mouse1.22944465
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.22451570
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.21370848
97E2F1_20622854_ChIP-Seq_HELA_Human1.21251724
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21160915
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21160915
100GATA6_21074721_ChIP-Seq_CACO-2_Human1.20960519
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20869165
102FOXH1_21741376_ChIP-Seq_ESCs_Human1.19510126
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18444129
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.18354131
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.16927778
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16233310
107TP53_18474530_ChIP-ChIP_U2OS_Human1.15422107
108AR_25329375_ChIP-Seq_VCAP_Human1.15231011
109DROSHA_22980978_ChIP-Seq_HELA_Human1.14503772
110ESR1_20079471_ChIP-ChIP_T-47D_Human1.13852052
111RUNX2_22187159_ChIP-Seq_PCA_Human1.13590259
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13418967
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12972459
114RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12847833
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.12505028
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.12445272
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.11951783
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.11744896
119RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11092262
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09949229
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09053314
122ARNT_22903824_ChIP-Seq_MCF-7_Human1.08779721
123STAT3_23295773_ChIP-Seq_U87_Human1.07881657
124TAF2_19829295_ChIP-Seq_ESCs_Human1.07580191
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.07152691
126KDM2B_26808549_Chip-Seq_REH_Human1.06641799
127GATA3_24758297_ChIP-Seq_MCF-7_Human1.06597047
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.06485413
129TBX20_22080862_ChIP-Seq_HEART_Mouse1.05295029
130TBX20_22328084_ChIP-Seq_HEART_Mouse1.05295029
131TCF4_23295773_ChIP-Seq_U87_Human1.04521485
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04406877
133KLF4_18555785_Chip-Seq_ESCs_Mouse1.04382671
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04258201
135UBF1/2_26484160_Chip-Seq_HMECs_Human1.04186820
136EWS_26573619_Chip-Seq_HEK293_Human1.04034895
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03309597
138CTCF_27219007_Chip-Seq_Bcells_Human1.01724853
139IRF1_19129219_ChIP-ChIP_H3396_Human1.00612002
140AHR_22903824_ChIP-Seq_MCF-7_Human0.99061212
141STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98961256
142ZFX_18555785_Chip-Seq_ESCs_Mouse0.98777335
143EGR1_19032775_ChIP-ChIP_M12_Human0.98275768
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.97722190
145RACK7_27058665_Chip-Seq_MCF-7_Human0.95532756
146P68_20966046_ChIP-Seq_HELA_Human0.93669575
147KLF5_25053715_ChIP-Seq_YYC3_Human0.93610829
148CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93411972
149TP53_20018659_ChIP-ChIP_R1E_Mouse0.92088371
150GATA4_25053715_ChIP-Seq_YYC3_Human0.90195498
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89879318
152SMC4_20622854_ChIP-Seq_HELA_Human0.87838440
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86766128
154HNFA_21074721_ChIP-Seq_CACO-2_Human0.85372590
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84854137
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83408228
157SA1_27219007_Chip-Seq_ERYTHROID_Human0.80683513
158HTT_18923047_ChIP-ChIP_STHdh_Human0.78834300
159CLOCK_20551151_ChIP-Seq_293T_Human0.78684790
160FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78112589
161FOXA1_25329375_ChIP-Seq_VCAP_Human0.78112589
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77717251
163EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.76961425
164RING1B_27294783_Chip-Seq_ESCs_Mouse0.76205081
165CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.75455921
166SMAD4_21741376_ChIP-Seq_ESCs_Human0.75444272
167PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73894185
168PHF8_20622853_ChIP-Seq_HELA_Human0.73466721
169TP53_16413492_ChIP-PET_HCT116_Human0.73279224
170RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72866001
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.72513762
172SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72298502
173SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71513092
174P53_21459846_ChIP-Seq_SAOS-2_Human0.71064840
175NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70708886
176NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70708886
177TBL1_22424771_ChIP-Seq_293T_Human0.70497324
178STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.70131856
179CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67930200
180SMAD3_21741376_ChIP-Seq_ESCs_Human0.64719933
181WT1_25993318_ChIP-Seq_PODOCYTE_Human0.64524242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.78957910
2MP0005275_abnormal_skin_tensile6.78299810
3MP0002098_abnormal_vibrissa_morphology4.90973428
4MP0010234_abnormal_vibrissa_follicle4.46589227
5MP0003880_abnormal_central_pattern4.01794999
6MP0003136_yellow_coat_color3.78384393
7MP0005501_abnormal_skin_physiology3.76992664
8MP0000377_abnormal_hair_follicle3.36936446
9MP0005075_abnormal_melanosome_morpholog3.18298313
10MP0006292_abnormal_olfactory_placode2.88416673
11MP0001188_hyperpigmentation2.85527715
12MP0004947_skin_inflammation2.78825184
13MP0005409_darkened_coat_color2.72111684
14MP0003705_abnormal_hypodermis_morpholog2.68775784
15MP0001216_abnormal_epidermal_layer2.61871540
16MP0003453_abnormal_keratinocyte_physiol2.59329333
17MP0010678_abnormal_skin_adnexa2.51791505
18MP0002102_abnormal_ear_morphology2.50822238
19MP0001486_abnormal_startle_reflex2.48471074
20MP0002060_abnormal_skin_morphology2.47835519
21MP0002095_abnormal_skin_pigmentation2.43818614
22MP0005423_abnormal_somatic_nervous2.41908288
23MP0000566_synostosis2.36176924
24MP0005171_absent_coat_pigmentation2.36018655
25MP0004742_abnormal_vestibular_system2.33109700
26MP0004381_abnormal_hair_follicle2.31463460
27MP0010771_integument_phenotype2.28791172
28MP0005646_abnormal_pituitary_gland2.16552235
29MP0009745_abnormal_behavioral_response2.15301594
30MP0002272_abnormal_nervous_system2.11927156
31MP0009046_muscle_twitch2.04626660
32MP0000778_abnormal_nervous_system1.99586510
33MP0002064_seizures1.95198071
34MP0001968_abnormal_touch/_nociception1.94304814
35MP0003635_abnormal_synaptic_transmissio1.92284459
36MP0004270_analgesia1.91503336
37MP0000920_abnormal_myelination1.91446612
38MP0004142_abnormal_muscle_tone1.90317358
39MP0000367_abnormal_coat/_hair1.87854216
40MP0002572_abnormal_emotion/affect_behav1.85233206
41MP0001905_abnormal_dopamine_level1.81912311
42MP0001243_abnormal_dermal_layer1.77732475
43MP0002735_abnormal_chemical_nociception1.76973069
44MP0001529_abnormal_vocalization1.76183770
45MP0000427_abnormal_hair_cycle1.73624583
46MP0001984_abnormal_olfaction1.73412246
47MP0002736_abnormal_nociception_after1.71262287
48MP0005645_abnormal_hypothalamus_physiol1.69937874
49MP0001485_abnormal_pinna_reflex1.66984460
50MP0006276_abnormal_autonomic_nervous1.66023254
51MP0005551_abnormal_eye_electrophysiolog1.65670481
52MP0005174_abnormal_tail_pigmentation1.64967011
53MP0003938_abnormal_ear_development1.63529089
54MP0003300_gastrointestinal_ulcer1.63369701
55MP0003011_delayed_dark_adaptation1.63277442
56MP0002067_abnormal_sensory_capabilities1.61397475
57MP0003878_abnormal_ear_physiology1.60749564
58MP0005377_hearing/vestibular/ear_phenot1.60749564
59MP0002063_abnormal_learning/memory/cond1.60230825
60MP0000026_abnormal_inner_ear1.58720034
61MP0002734_abnormal_mechanical_nocicepti1.58474018
62MP0001440_abnormal_grooming_behavior1.58353955
63MP0004859_abnormal_synaptic_plasticity1.58163876
64MP0009931_abnormal_skin_appearance1.55659986
65MP0001963_abnormal_hearing_physiology1.46487962
66MP0000631_abnormal_neuroendocrine_gland1.45991714
67MP0010386_abnormal_urinary_bladder1.44777507
68MP0002557_abnormal_social/conspecific_i1.44775837
69MP0002184_abnormal_innervation1.42657499
70MP0001501_abnormal_sleep_pattern1.39683995
71MP0002277_abnormal_respiratory_mucosa1.35631987
72MP0005647_abnormal_sex_gland1.33688090
73MP0000049_abnormal_middle_ear1.33073460
74MP0004885_abnormal_endolymph1.32467420
75MP0001986_abnormal_taste_sensitivity1.30531719
76MP0002638_abnormal_pupillary_reflex1.27573694
77MP0006072_abnormal_retinal_apoptosis1.23502296
78MP0002249_abnormal_larynx_morphology1.23347361
79MP0001970_abnormal_pain_threshold1.22251022
80MP0002876_abnormal_thyroid_physiology1.21878169
81MP0002752_abnormal_somatic_nervous1.21425047
82MP0003787_abnormal_imprinting1.20963890
83MP0001502_abnormal_circadian_rhythm1.18745935
84MP0008260_abnormal_autophagy1.14331479
85MP0003690_abnormal_glial_cell1.13985552
86MP0002882_abnormal_neuron_morphology1.13139244
87MP0000467_abnormal_esophagus_morphology1.07633417
88MP0001191_abnormal_skin_condition1.06355698
89MP0002938_white_spotting1.04575951
90MP0008789_abnormal_olfactory_epithelium1.03152835
91MP0002733_abnormal_thermal_nociception1.02476451
92MP0002822_catalepsy1.01054417
93MP0003941_abnormal_skin_development0.99933440
94MP0004134_abnormal_chest_morphology0.99098402
95MP0005253_abnormal_eye_physiology0.99075769
96MP0003950_abnormal_plasma_membrane0.98952033
97MP0002229_neurodegeneration0.98401437
98MP0003634_abnormal_glial_cell0.96687158
99MP0000647_abnormal_sebaceous_gland0.96631052
100MP0000762_abnormal_tongue_morphology0.95523939
101MP0005379_endocrine/exocrine_gland_phen0.95463131
102MP0000015_abnormal_ear_pigmentation0.95359706
103MP0002066_abnormal_motor_capabilities/c0.94334956
104MP0009250_abnormal_appendicular_skeleto0.93837796
105MP0008569_lethality_at_weaning0.92920206
106MP0009379_abnormal_foot_pigmentation0.91353471
107MP0005394_taste/olfaction_phenotype0.90062426
108MP0005499_abnormal_olfactory_system0.90062426
109MP0000383_abnormal_hair_follicle0.89614730
110MP0003937_abnormal_limbs/digits/tail_de0.87847108
111MP0004924_abnormal_behavior0.87839442
112MP0005386_behavior/neurological_phenoty0.87839442
113MP0001346_abnormal_lacrimal_gland0.87781070
114MP0000462_abnormal_digestive_system0.87028752
115MP0008995_early_reproductive_senescence0.86651798
116MP0000579_abnormal_nail_morphology0.86640923
117MP0000955_abnormal_spinal_cord0.86046896
118MP0000372_irregular_coat_pigmentation0.85329163
119MP0005195_abnormal_posterior_eye0.84885447
120MP0003879_abnormal_hair_cell0.82275134
121MP0001664_abnormal_digestion0.81775688
122MP0001661_extended_life_span0.81355933
123MP0002751_abnormal_autonomic_nervous0.78852412
124MP0005451_abnormal_body_composition0.78518931
125MP0010030_abnormal_orbit_morphology0.76893180
126MP0005410_abnormal_fertilization0.74819862
127MP0002152_abnormal_brain_morphology0.74231665
128MP0002177_abnormal_outer_ear0.73907176
129MP0003315_abnormal_perineum_morphology0.72064250
130MP0004145_abnormal_muscle_electrophysio0.71531513
131MP0003566_abnormal_cell_adhesion0.68388018
132MP0006035_abnormal_mitochondrial_morpho0.60049612
133MP0001851_eye_inflammation0.59214657
134MP0003763_abnormal_thymus_physiology0.59132793
135MP0001784_abnormal_fluid_regulation0.58179101
136MP0002282_abnormal_trachea_morphology0.53077142
137MP0002009_preneoplasia0.51633419
138MP0004782_abnormal_surfactant_physiolog0.46906600
139MP0004858_abnormal_nervous_system0.44491391
140MP0009780_abnormal_chondrocyte_physiolo0.42992575
141MP0000465_gastrointestinal_hemorrhage0.40377358
142MP0005503_abnormal_tendon_morphology0.33868967
143MP0005535_abnormal_body_temperature0.33032786
144MP0003638_abnormal_response/metabolism_0.31811644
145MP0002970_abnormal_white_adipose0.31122168
146MP0002166_altered_tumor_susceptibility0.29987043
147MP0001186_pigmentation_phenotype0.29178011
148MP0000685_abnormal_immune_system0.27476463
149MP0003191_abnormal_cellular_cholesterol0.26865467
150MP0001340_abnormal_eyelid_morphology0.24196296
151MP0000751_myopathy0.21795131
152MP0001958_emphysema0.20306338
153MP0002006_tumorigenesis0.19301049
154MP0004019_abnormal_vitamin_homeostasis0.17665039
155MP0005023_abnormal_wound_healing0.17551147
156MP0004264_abnormal_extraembryonic_tissu0.17389445
157MP0002111_abnormal_tail_morphology0.17286062
158MP0008438_abnormal_cutaneous_collagen0.17203217
159MP0001849_ear_inflammation0.16500817
160MP0000627_abnormal_mammary_gland0.16268140
161MP0001919_abnormal_reproductive_system0.14946888
162MP0002163_abnormal_gland_morphology0.14660300
163MP0002877_abnormal_melanocyte_morpholog0.13730640
164MP0009053_abnormal_anal_canal0.13691500
165MP0005508_abnormal_skeleton_morphology0.12838841
166MP0009384_cardiac_valve_regurgitation0.11634319
167MP0002971_abnormal_brown_adipose0.10598932
168MP0006138_congestive_heart_failure0.10280317
169MP0005248_abnormal_Harderian_gland0.09667571
170MP0002148_abnormal_hypersensitivity_rea0.08439383
171MP0004185_abnormal_adipocyte_glucose0.06764327
172MP0000428_abnormal_craniofacial_morphol0.06069977
173MP0004272_abnormal_basement_membrane0.06047415
174MP0003755_abnormal_palate_morphology0.04571510
175MP0002133_abnormal_respiratory_system0.03185961
176MP0005388_respiratory_system_phenotype0.03185961
177MP0005666_abnormal_adipose_tissue0.02331875
178MP0002118_abnormal_lipid_homeostasis0.02111144
179MP0002109_abnormal_limb_morphology0.01899034
180MP0002108_abnormal_muscle_morphology0.01764288
181MP0001666_abnormal_nutrient_absorption0.01707029

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.85246129
2Woolly hair (HP:0002224)9.61047325
3Hypotrichosis (HP:0001006)9.30196334
4Onycholysis (HP:0001806)9.14668754
5Conjunctival hamartoma (HP:0100780)7.45568341
6Palmoplantar hyperkeratosis (HP:0000972)7.39006090
7Abnormal hair laboratory examination (HP:0003328)7.27424470
8Abnormality of hair growth rate (HP:0011363)7.23526755
9Slow-growing hair (HP:0002217)7.23526755
10Erythroderma (HP:0001019)7.19829491
11Palmar hyperkeratosis (HP:0010765)7.03088897
12Brittle hair (HP:0002299)6.81110115
13Erythema (HP:0010783)6.67393502
14Plantar hyperkeratosis (HP:0007556)6.00389814
15Absent eyelashes (HP:0000561)5.28813105
16Abnormality of nail color (HP:0100643)5.17065100
17Hamartoma of the eye (HP:0010568)5.02581891
18Alopecia of scalp (HP:0002293)4.69805562
19Dry hair (HP:0011359)4.62015632
20Thick nail (HP:0001805)4.50700729
21Parakeratosis (HP:0001036)4.31589235
22Nail dystrophy (HP:0008404)4.02071303
23Absent hair (HP:0002298)4.02031756
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.93442489
25Absent/shortened dynein arms (HP:0200106)3.93442489
26Absent eyebrow (HP:0002223)3.87441379
27Abnormal ciliary motility (HP:0012262)3.70115637
28Focal motor seizures (HP:0011153)3.68842568
29Sparse eyelashes (HP:0000653)3.62935039
30Fine hair (HP:0002213)3.53949656
31Septo-optic dysplasia (HP:0100842)3.50729034
32Abnormal blistering of the skin (HP:0008066)3.45591862
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.39682962
34Right ventricular cardiomyopathy (HP:0011663)3.35797034
35Palmoplantar keratoderma (HP:0000982)3.25988614
36Degeneration of the lateral corticospinal tracts (HP:0002314)3.20289238
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.20289238
38Abnormal respiratory epithelium morphology (HP:0012253)3.18308285
39Abnormal respiratory motile cilium morphology (HP:0005938)3.18308285
40Follicular hyperkeratosis (HP:0007502)3.17129386
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15448987
42Abnormal respiratory motile cilium physiology (HP:0012261)3.15219282
43Abnormality of the axillary hair (HP:0100134)3.08740153
44Abnormality of secondary sexual hair (HP:0009888)3.08740153
45Fragile nails (HP:0001808)3.06556506
46Corneal erosion (HP:0200020)2.97573606
47Absent septum pellucidum (HP:0001331)2.83116911
48Aplasia cutis congenita (HP:0001057)2.81959672
49White forelock (HP:0002211)2.78676972
50Patchy hypopigmentation of hair (HP:0011365)2.72209390
51Hyperventilation (HP:0002883)2.65660228
52Optic nerve hypoplasia (HP:0000609)2.64271069
53Febrile seizures (HP:0002373)2.63779513
54Hypergammaglobulinemia (HP:0010702)2.59948985
55Abnormality of the septum pellucidum (HP:0007375)2.58625235
56Epileptic encephalopathy (HP:0200134)2.56388249
57Sparse scalp hair (HP:0002209)2.54107305
58Aplasia involving bones of the upper limbs (HP:0009823)2.54030045
59Aplasia of the phalanges of the hand (HP:0009802)2.54030045
60Aplasia involving bones of the extremities (HP:0009825)2.54030045
61Gangrene (HP:0100758)2.53434608
62Congenital, generalized hypertrichosis (HP:0004540)2.52134235
63Neurofibrillary tangles (HP:0002185)2.50377615
64Hamartoma (HP:0010566)2.47632063
65Medial flaring of the eyebrow (HP:0010747)2.47367616
66Ridged nail (HP:0001807)2.44358215
67Nasolacrimal duct obstruction (HP:0000579)2.41937506
68Abnormality of the pupil (HP:0000615)2.39065672
69Retinal dysplasia (HP:0007973)2.34971384
70Hypohidrosis (HP:0000966)2.34837648
71Milia (HP:0001056)2.34148240
72Thyroid-stimulating hormone excess (HP:0002925)2.30515751
73Decreased central vision (HP:0007663)2.27731995
74Sensory axonal neuropathy (HP:0003390)2.26934529
75Hypothermia (HP:0002045)2.25821546
76Cupped ear (HP:0000378)2.25028266
77Gait imbalance (HP:0002141)2.24917650
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.23072666
79Conical tooth (HP:0000698)2.20803098
80Melanocytic nevus (HP:0000995)2.20028970
81Anomalous pulmonary venous return (HP:0010772)2.18895779
82Blepharitis (HP:0000498)2.16627314
83Alacrima (HP:0000522)2.14581980
84Atonic seizures (HP:0010819)2.14356988
85Duplicated collecting system (HP:0000081)2.14304551
86Nephrogenic diabetes insipidus (HP:0009806)2.13585219
87Synostosis involving the elbow (HP:0003938)2.13372026
88Humeroradial synostosis (HP:0003041)2.13372026
89Short tibia (HP:0005736)2.12339475
90Broad-based gait (HP:0002136)2.12026451
91Abnormality of incisor morphology (HP:0011063)2.11782131
92Congenital sensorineural hearing impairment (HP:0008527)2.11562883
93Congenital primary aphakia (HP:0007707)2.10076212
94Thickened helices (HP:0000391)2.09392506
95Genital tract atresia (HP:0001827)2.08564161
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07783267
97Morphological abnormality of the middle ear (HP:0008609)2.07402243
98Abnormality of the corticospinal tract (HP:0002492)2.05212849
99Abnormality of the lacrimal duct (HP:0011481)2.03724093
100Congenital ichthyosiform erythroderma (HP:0007431)2.03378366
101Decreased lacrimation (HP:0000633)2.02612913
102Vaginal atresia (HP:0000148)2.02134217
103Aplasia/Hypoplasia of the lens (HP:0008063)2.00872367
104Pili torti (HP:0003777)10.5376471
105Abnormality of the nasolacrimal system (HP:0000614)1.99618714
106Duplication of thumb phalanx (HP:0009942)1.95804069
107Metabolic alkalosis (HP:0200114)1.94448944
108Coarse hair (HP:0002208)1.94092775
109Overfolded helix (HP:0000396)1.93427180
110Hypomagnesemia (HP:0002917)1.92685535
111Acanthosis nigricans (HP:0000956)1.92325254
112Abnormality of the salivary glands (HP:0010286)1.92246141
113Optic disc pallor (HP:0000543)1.91739772
114Pruritus (HP:0000989)1.90575825
115Abnormality of the renal collecting system (HP:0004742)1.90407483
116Advanced eruption of teeth (HP:0006288)1.90402296
117Corneal dystrophy (HP:0001131)1.90327897
118Abnormality of the pulmonary veins (HP:0011718)1.89609195
119Rhinitis (HP:0012384)1.88550178
120Atelectasis (HP:0100750)1.87883802
121Split foot (HP:0001839)1.86965689
122Abnormal hair whorl (HP:0010721)1.86719576
123True hermaphroditism (HP:0010459)1.86533808
124Natal tooth (HP:0000695)1.85406855
125Tubulointerstitial nephritis (HP:0001970)1.83983618
126Recurrent corneal erosions (HP:0000495)1.80194962
127Mixed hearing impairment (HP:0000410)1.79494647
128Focal seizures (HP:0007359)1.78989968
129Sex reversal (HP:0012245)1.78507136
130Abnormal sex determination (HP:0012244)1.78507136
131Hypophosphatemic rickets (HP:0004912)1.78054403
132Esotropia (HP:0000565)1.78043561
133Progressive cerebellar ataxia (HP:0002073)1.76754725
134Hypoplastic left heart (HP:0004383)1.73154275
135Pancreatic fibrosis (HP:0100732)1.71985428
136Abnormality of permanent molar morphology (HP:0011071)1.71969488
137Abnormality of the dental root (HP:0006486)1.71969488
138Taurodontia (HP:0000679)1.71969488
139Nephronophthisis (HP:0000090)1.70662533
140Keratoconus (HP:0000563)1.70600027
141Increased corneal curvature (HP:0100692)1.70600027
142Abnormality of the renal medulla (HP:0100957)1.69936684
143Attenuation of retinal blood vessels (HP:0007843)1.69373465
1443-Methylglutaconic aciduria (HP:0003535)1.69007973
145Oral leukoplakia (HP:0002745)1.68732565
146Abnormality of the neuromuscular junction (HP:0003398)1.68351074
147Fatigable weakness (HP:0003473)1.68351074
148Gaze-evoked nystagmus (HP:0000640)1.68226657
149Hypoplastic heart (HP:0001961)1.67069885
150Symphalangism affecting the phalanges of the hand (HP:0009773)1.66624026
151Partial duplication of thumb phalanx (HP:0009944)1.66473369
152Acute necrotizing encephalopathy (HP:0006965)1.66329830
153Amelogenesis imperfecta (HP:0000705)1.65961083
154Dialeptic seizures (HP:0011146)1.65906765
155Abnormality of molar (HP:0011077)1.65557147
156Septate vagina (HP:0001153)1.62946712
157Abnormality of molar morphology (HP:0011070)1.61398793
158Ventricular tachycardia (HP:0004756)1.58459384
159Urticaria (HP:0001025)1.55598239
160Abnormality of the dental pulp (HP:0006479)1.54892559
161Skin ulcer (HP:0200042)1.50743007
162Verrucae (HP:0200043)1.46177112
163Papilloma (HP:0012740)1.46177112
164Lip pit (HP:0100267)1.44983140
165Hyperhidrosis (HP:0000975)1.44470166
166Furrowed tongue (HP:0000221)1.38088245
167Xerostomia (HP:0000217)1.37566167
168Eczematoid dermatitis (HP:0000976)1.31560475
169Hypoplastic labia majora (HP:0000059)1.26799548
170Ectropion (HP:0000656)1.24531759
171Neonatal short-limb short stature (HP:0008921)1.24367582
172Neonatal death (HP:0003811)1.24169604
173Multifactorial inheritance (HP:0001426)1.15308872
174Ventricular fibrillation (HP:0001663)1.15096960
175Abnormality of the labia majora (HP:0012881)1.15074864
176Craniofacial hyperostosis (HP:0004493)1.14833474
177Dry skin (HP:0000958)1.10662618
178Oligodontia (HP:0000677)1.06233413
179Selective tooth agenesis (HP:0001592)1.05512963
180Abnormality of the fingernails (HP:0001231)1.05466923
181Depressed nasal tip (HP:0000437)0.99754784
182Seborrheic dermatitis (HP:0001051)0.99592970
183Curly hair (HP:0002212)0.99103534
184Subcapsular cataract (HP:0000523)0.95588934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K6.17081731
2MAPKAPK35.52567940
3CASK5.48859325
4TGFBR14.56203834
5MAP3K64.52900777
6TNIK3.51494133
7STK243.04222194
8FER2.64727225
9STK392.64694853
10FGFR32.60235815
11TRPM72.48575529
12BLK2.42792852
13RPS6KB22.37441705
14STK162.30345656
15OXSR12.29825522
16EPHA42.26867994
17RIPK12.23004653
18PNCK2.09262336
19MKNK22.05574571
20EPHB22.02625961
21FGFR12.01027890
22MYLK2.00393094
23PIK3CG1.96989684
24PKN11.93652395
25MAPK131.90199779
26PRPF4B1.89664858
27MUSK1.86875477
28MAP2K71.85756991
29TAF11.85288059
30NTRK31.75376396
31AKT31.59634537
32GRK71.57720860
33NEK61.56958753
34MARK11.56667533
35ADRBK21.54003500
36MAP3K21.49111527
37LATS11.45263173
38CDK31.40592069
39BCR1.39665916
40BMPR1B1.39017942
41MKNK11.37035520
42BMPR21.36127412
43LMTK21.34686902
44EPHA31.34456054
45YES11.33294658
46MST41.32614508
47FGR1.32167359
48MAP2K61.31022890
49NTRK21.26679855
50GRK11.23556152
51MAPKAPK51.20651690
52MST1R1.19810720
53ERN11.18244739
54CAMK2B1.14856287
55MAPK151.13630144
56PBK1.11974533
57INSRR1.10482729
58NME11.07535890
59UHMK11.07372702
60MAP2K41.05355251
61DYRK21.04744371
62PRKCE1.03519650
63RPS6KB11.01539703
64IRAK20.99031658
65KIT0.98716573
66FES0.97566425
67WNK40.97487464
68MAPKAPK20.96531153
69CAMK2A0.96481502
70MAP3K70.93568347
71DYRK1A0.92836901
72EIF2AK20.91110267
73SGK2230.89861143
74SGK4940.89861143
75IRAK10.87862482
76EPHB10.87539595
77CDK190.86677185
78CSNK1A1L0.86262295
79CLK10.85242547
80CSNK1G30.83163471
81FGFR40.80619014
82KSR20.79991484
83SIK10.79406565
84MARK20.78992136
85CAMK2D0.76842932
86SMG10.76649408
87TNK20.76124965
88TXK0.74647926
89ROCK20.73620584
90WNK10.73613216
91PRKAA20.73406242
92TRIB30.73140440
93CSNK1G20.72393257
94PLK20.71263493
95WNK30.67327576
96CSNK1G10.67208396
97ADRBK10.66393358
98EPHA20.64829809
99DYRK1B0.64814184
100CDK60.64580270
101PRKCG0.64184722
102MAP3K40.63577067
103CDK50.63258552
104PDK20.63251302
105LRRK20.62743189
106IRAK30.62326428
107PRKG10.61716892
108PRKD10.61669186
109GRK50.61475355
110IRAK40.61419003
111RET0.61397177
112MAP3K140.60904363
113PINK10.59137900
114NTRK10.58829313
115CAMK10.56665442
116CDC42BPA0.56272518
117PIK3CA0.55999761
118CAMK2G0.55656291
119PRKCQ0.54960230
120MAP3K10.54946130
121STK30.54808052
122MAPK120.54323129
123ILK0.52692125
124MAP3K120.51735432
125PRKACA0.51453121
126PTK20.51411644
127RIPK40.51290097
128PTK60.50465080
129MAPK110.49357800
130SIK30.49017998
131MAP3K30.47647196
132CAMK1G0.47230615
133SGK20.46833108
134MAPK70.46525243
135PRKD20.44758899
136SRPK10.44551508
137SIK20.44443909
138VRK10.43416223
139IKBKB0.42698833
140RPS6KA20.42516239
141NLK0.41922706
142SGK30.41254655
143PAK30.40673453
144ERBB40.40347475
145PAK60.38960611
146ICK0.38885171
147LATS20.38373031
148FYN0.38015655
149JAK20.37853041
150MAPK40.37316951
151STK38L0.37147818
152SGK10.36529805
153TGFBR20.35835986
154CSNK1A10.35492028
155OBSCN0.35029844
156DAPK20.34783705
157FGFR20.33733902
158PDGFRA0.33408925
159CSK0.33104149
160MINK10.33077151
161NUAK10.32953498
162GSK3A0.31815958
163ABL20.31678948
164DMPK0.31553646
165PHKG10.31378572
166PHKG20.31378572
167TIE10.30423072
168HIPK20.27969823
169MTOR0.27484884
170ITK0.27013704
171ZAP700.25576421
172IGF1R0.24900164
173TYK20.24752825
174MET0.21996896
175HCK0.21766663
176ERBB20.21419978
177MAPK90.20214758
178MATK0.18311497
179TESK10.18179481

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.47461889
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64393707
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53068970
4Fatty acid metabolism_Homo sapiens_hsa012122.45763789
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.43223287
6Phototransduction_Homo sapiens_hsa047442.40187999
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32517659
8Steroid biosynthesis_Homo sapiens_hsa001002.29212146
9Serotonergic synapse_Homo sapiens_hsa047262.26578945
10Fatty acid elongation_Homo sapiens_hsa000622.24752333
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19943480
12Oxidative phosphorylation_Homo sapiens_hsa001902.19679261
13Taste transduction_Homo sapiens_hsa047422.14196627
14Morphine addiction_Homo sapiens_hsa050322.12640841
15Ether lipid metabolism_Homo sapiens_hsa005652.10249323
16Glutamatergic synapse_Homo sapiens_hsa047242.07407837
17GABAergic synapse_Homo sapiens_hsa047272.02081367
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95739206
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82918838
20Sphingolipid metabolism_Homo sapiens_hsa006001.76573832
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.74566001
22Axon guidance_Homo sapiens_hsa043601.72823365
23PPAR signaling pathway_Homo sapiens_hsa033201.65966129
24Collecting duct acid secretion_Homo sapiens_hsa049661.63991098
25Circadian entrainment_Homo sapiens_hsa047131.54966869
26beta-Alanine metabolism_Homo sapiens_hsa004101.54675864
27Phenylalanine metabolism_Homo sapiens_hsa003601.52304993
28Staphylococcus aureus infection_Homo sapiens_hsa051501.51494474
29Glycerolipid metabolism_Homo sapiens_hsa005611.48809173
30Alzheimers disease_Homo sapiens_hsa050101.47871437
31Fatty acid degradation_Homo sapiens_hsa000711.45547525
32Salivary secretion_Homo sapiens_hsa049701.43461867
33GnRH signaling pathway_Homo sapiens_hsa049121.40873396
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39621442
35Calcium signaling pathway_Homo sapiens_hsa040201.34274684
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.33749052
37Arachidonic acid metabolism_Homo sapiens_hsa005901.31878025
38Autoimmune thyroid disease_Homo sapiens_hsa053201.30863046
39Protein export_Homo sapiens_hsa030601.30765345
40Olfactory transduction_Homo sapiens_hsa047401.27129258
41Long-term depression_Homo sapiens_hsa047301.24616915
42Rheumatoid arthritis_Homo sapiens_hsa053231.24404605
43Parkinsons disease_Homo sapiens_hsa050121.23237952
44ECM-receptor interaction_Homo sapiens_hsa045121.18750495
45Linoleic acid metabolism_Homo sapiens_hsa005911.16182843
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09836524
47Synaptic vesicle cycle_Homo sapiens_hsa047211.08065033
48Amphetamine addiction_Homo sapiens_hsa050311.07678422
49Renin secretion_Homo sapiens_hsa049241.00457093
50Cardiac muscle contraction_Homo sapiens_hsa042600.97660841
51Huntingtons disease_Homo sapiens_hsa050160.97203252
52Cocaine addiction_Homo sapiens_hsa050300.96794692
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96042849
54Fat digestion and absorption_Homo sapiens_hsa049750.95825511
55Graft-versus-host disease_Homo sapiens_hsa053320.95718070
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95418030
57Cholinergic synapse_Homo sapiens_hsa047250.95100476
58Dopaminergic synapse_Homo sapiens_hsa047280.94722554
59Insulin secretion_Homo sapiens_hsa049110.93340533
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90053656
61Gastric acid secretion_Homo sapiens_hsa049710.89185865
62Vibrio cholerae infection_Homo sapiens_hsa051100.86107593
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83637570
64Histidine metabolism_Homo sapiens_hsa003400.83543472
65Ovarian steroidogenesis_Homo sapiens_hsa049130.83145657
66Ras signaling pathway_Homo sapiens_hsa040140.81598194
67VEGF signaling pathway_Homo sapiens_hsa043700.80724515
68Glioma_Homo sapiens_hsa052140.80700381
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80012506
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79180428
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77978337
72Mineral absorption_Homo sapiens_hsa049780.75872768
73cAMP signaling pathway_Homo sapiens_hsa040240.75561814
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.73491741
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73262446
76Pancreatic secretion_Homo sapiens_hsa049720.72957203
77Wnt signaling pathway_Homo sapiens_hsa043100.71077952
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70269024
79Oxytocin signaling pathway_Homo sapiens_hsa049210.70122480
80Phagosome_Homo sapiens_hsa041450.68964768
81Peroxisome_Homo sapiens_hsa041460.68639523
82Long-term potentiation_Homo sapiens_hsa047200.67289505
83African trypanosomiasis_Homo sapiens_hsa051430.67271555
84Renin-angiotensin system_Homo sapiens_hsa046140.64423283
85Pertussis_Homo sapiens_hsa051330.63277393
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62858876
87Lysosome_Homo sapiens_hsa041420.61770522
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61361659
89Allograft rejection_Homo sapiens_hsa053300.60770803
90Asthma_Homo sapiens_hsa053100.59966964
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59572767
92Fatty acid biosynthesis_Homo sapiens_hsa000610.59336929
93Tyrosine metabolism_Homo sapiens_hsa003500.59198217
94Pyruvate metabolism_Homo sapiens_hsa006200.58392737
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55426585
96Arginine and proline metabolism_Homo sapiens_hsa003300.54939843
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54277378
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52972482
99Estrogen signaling pathway_Homo sapiens_hsa049150.52324149
100Melanogenesis_Homo sapiens_hsa049160.51847525
101Vitamin digestion and absorption_Homo sapiens_hsa049770.50612760
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50377156
103Melanoma_Homo sapiens_hsa052180.50270428
104Fanconi anemia pathway_Homo sapiens_hsa034600.48750267
105Hedgehog signaling pathway_Homo sapiens_hsa043400.47083486
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46630658
107Gap junction_Homo sapiens_hsa045400.46616253
108Protein digestion and absorption_Homo sapiens_hsa049740.46075613
109Circadian rhythm_Homo sapiens_hsa047100.45710559
110Sulfur metabolism_Homo sapiens_hsa009200.44434387
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44399475
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.44251877
113Regulation of autophagy_Homo sapiens_hsa041400.43788556
114Basal transcription factors_Homo sapiens_hsa030220.43662961
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43552866
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42099726
117Tuberculosis_Homo sapiens_hsa051520.41846048
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41106699
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.41094053
120Basal cell carcinoma_Homo sapiens_hsa052170.39937769
121ErbB signaling pathway_Homo sapiens_hsa040120.39710531
122Dorso-ventral axis formation_Homo sapiens_hsa043200.39069771
123Retinol metabolism_Homo sapiens_hsa008300.38442778
124MAPK signaling pathway_Homo sapiens_hsa040100.37900960
125Platelet activation_Homo sapiens_hsa046110.37723282
126Hematopoietic cell lineage_Homo sapiens_hsa046400.37686847
127Choline metabolism in cancer_Homo sapiens_hsa052310.35565109
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.34499927
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34423929
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.34183047
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33247717
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.29706211
133Focal adhesion_Homo sapiens_hsa045100.26750514
134Notch signaling pathway_Homo sapiens_hsa043300.25771791
135Insulin signaling pathway_Homo sapiens_hsa049100.25255743
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24882741
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22416793
138Lysine degradation_Homo sapiens_hsa003100.21959203
139Propanoate metabolism_Homo sapiens_hsa006400.21120820
140Acute myeloid leukemia_Homo sapiens_hsa052210.20112178
141Rap1 signaling pathway_Homo sapiens_hsa040150.19912527
142Glucagon signaling pathway_Homo sapiens_hsa049220.19688630
143Inositol phosphate metabolism_Homo sapiens_hsa005620.18071701
144Nitrogen metabolism_Homo sapiens_hsa009100.17098871
145Thyroid cancer_Homo sapiens_hsa052160.17064181
146Tryptophan metabolism_Homo sapiens_hsa003800.16861259
147Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16728921
148Adherens junction_Homo sapiens_hsa045200.15747572
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15073765
150MicroRNAs in cancer_Homo sapiens_hsa052060.13682936
151Malaria_Homo sapiens_hsa051440.13504775

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