DENND5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03548006
2L-phenylalanine catabolic process (GO:0006559)5.03548006
3presynaptic membrane assembly (GO:0097105)4.93609480
4aromatic amino acid family catabolic process (GO:0009074)4.77420247
5neurotransmitter-gated ion channel clustering (GO:0072578)4.73592330
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.68708676
7L-phenylalanine metabolic process (GO:0006558)4.68708676
8indole-containing compound catabolic process (GO:0042436)4.58552878
9indolalkylamine catabolic process (GO:0046218)4.58552878
10tryptophan catabolic process (GO:0006569)4.58552878
11presynaptic membrane organization (GO:0097090)4.44523441
12tryptophan metabolic process (GO:0006568)4.24900166
13bile acid biosynthetic process (GO:0006699)4.12294582
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08898054
15vocalization behavior (GO:0071625)4.06620809
16kynurenine metabolic process (GO:0070189)4.06407668
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02630375
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99381253
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96120977
20neuron cell-cell adhesion (GO:0007158)3.96053850
21urea metabolic process (GO:0019627)3.92272827
22urea cycle (GO:0000050)3.92272827
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89867679
24postsynaptic membrane organization (GO:0001941)3.71000046
25high-density lipoprotein particle remodeling (GO:0034375)3.68303214
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67703519
27regulation of fibrinolysis (GO:0051917)3.66182560
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.60358231
29serine family amino acid catabolic process (GO:0009071)3.57953181
30nitrogen cycle metabolic process (GO:0071941)3.57682867
31gamma-aminobutyric acid transport (GO:0015812)3.55507236
32aromatic amino acid family metabolic process (GO:0009072)3.55097741
33glutamate metabolic process (GO:0006536)3.54795357
34glutamate secretion (GO:0014047)3.54542343
35protein localization to synapse (GO:0035418)3.54101240
36coenzyme catabolic process (GO:0009109)3.53889596
37regulation of glutamate receptor signaling pathway (GO:1900449)3.53032776
38axonal fasciculation (GO:0007413)3.51808670
39bile acid metabolic process (GO:0008206)3.51452366
40startle response (GO:0001964)3.48854411
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47003056
42negative regulation of fibrinolysis (GO:0051918)3.41308743
43alpha-amino acid catabolic process (GO:1901606)3.40792787
44dicarboxylic acid biosynthetic process (GO:0043650)3.39956223
45tyrosine metabolic process (GO:0006570)3.37591851
46cellular biogenic amine catabolic process (GO:0042402)3.37012180
47amine catabolic process (GO:0009310)3.37012180
48glyoxylate metabolic process (GO:0046487)3.35204312
49indolalkylamine metabolic process (GO:0006586)3.34507819
50regulation of protein activation cascade (GO:2000257)3.33338329
51regulation of bile acid biosynthetic process (GO:0070857)3.32417132
52cellular ketone body metabolic process (GO:0046950)3.31894874
53pyrimidine nucleobase catabolic process (GO:0006208)3.31788319
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30953141
55neuron recognition (GO:0008038)3.28697813
56cerebral cortex radially oriented cell migration (GO:0021799)3.25717516
57regulation of short-term neuronal synaptic plasticity (GO:0048172)3.25433657
58indole-containing compound metabolic process (GO:0042430)3.22683364
59regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.22433048
60neuron-neuron synaptic transmission (GO:0007270)3.20213792
61acylglycerol homeostasis (GO:0055090)3.17634460
62triglyceride homeostasis (GO:0070328)3.17634460
63regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.17467266
64neurotransmitter secretion (GO:0007269)3.16617088
65regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16308252
66reverse cholesterol transport (GO:0043691)3.16265252
67complement activation, alternative pathway (GO:0006957)3.15988452
68synaptic vesicle exocytosis (GO:0016079)3.15524862
69dendritic spine morphogenesis (GO:0060997)3.15005455
70neuronal action potential propagation (GO:0019227)3.14426763
71synaptic transmission, glutamatergic (GO:0035249)3.13855201
72regulation of cholesterol esterification (GO:0010872)3.12537701
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.12254155
74plasma lipoprotein particle remodeling (GO:0034369)3.10417101
75protein-lipid complex remodeling (GO:0034368)3.10417101
76macromolecular complex remodeling (GO:0034367)3.10417101
77NAD biosynthetic process (GO:0009435)3.07699066
78cardiac myofibril assembly (GO:0055003)3.07623992
79cellular amino acid catabolic process (GO:0009063)3.04291856
80regulation of complement activation (GO:0030449)3.02709722
81cell communication by electrical coupling (GO:0010644)3.02187637
82dicarboxylic acid catabolic process (GO:0043649)3.01846719
83regulation of synaptic vesicle exocytosis (GO:2000300)3.01792941
84regulation of cardiac muscle cell contraction (GO:0086004)3.00503383
85arginine metabolic process (GO:0006525)2.99062404
86regulation of protein glycosylation (GO:0060049)2.97741453
87glutamate receptor signaling pathway (GO:0007215)2.97467611
88bile acid and bile salt transport (GO:0015721)2.95952800
89mechanosensory behavior (GO:0007638)2.95801567
90imidazole-containing compound metabolic process (GO:0052803)2.95647842
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95217242
92drug catabolic process (GO:0042737)2.94923618
93ketone body metabolic process (GO:1902224)2.94815072
94cholesterol efflux (GO:0033344)2.92499900
95auditory behavior (GO:0031223)2.90504967
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.90056203
97peptidyl-glutamic acid carboxylation (GO:0017187)2.89968379
98protein carboxylation (GO:0018214)2.89968379
99regulation of relaxation of muscle (GO:1901077)2.89283809
100negative regulation of dendrite morphogenesis (GO:0050774)2.88579405
101regulation of actin filament-based movement (GO:1903115)2.88024056
102central nervous system projection neuron axonogenesis (GO:0021952)2.85772582
103cerebellar granule cell differentiation (GO:0021707)2.83350183
104omega-hydroxylase P450 pathway (GO:0097267)2.82926499
105negative regulation of protein activation cascade (GO:2000258)2.82538294
106alpha-linolenic acid metabolic process (GO:0036109)2.82426896
107regulation of triglyceride catabolic process (GO:0010896)2.82279085
108positive regulation of dendritic spine morphogenesis (GO:0061003)2.81921350
109behavioral response to nicotine (GO:0035095)2.81544655
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81360599
111cell communication involved in cardiac conduction (GO:0086065)2.79967043
112nucleobase catabolic process (GO:0046113)2.78852441
113negative regulation of dendrite development (GO:2000171)2.78434361
114limb bud formation (GO:0060174)2.77778615
115behavioral response to cocaine (GO:0048148)2.77674608
116homocysteine metabolic process (GO:0050667)2.76459411
117myofibril assembly (GO:0030239)2.75942285
118NAD metabolic process (GO:0019674)2.75212209
119regulation of cell communication by electrical coupling (GO:0010649)2.74795148
120cysteine metabolic process (GO:0006534)2.74269073
121cofactor catabolic process (GO:0051187)2.74238479
122regulation of excitatory postsynaptic membrane potential (GO:0060079)2.73190388
123phospholipid efflux (GO:0033700)2.72875792
124regulation of synaptic vesicle transport (GO:1902803)2.72310222
125lysine catabolic process (GO:0006554)2.71910031
126lysine metabolic process (GO:0006553)2.71910031
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.71443629
128C4-dicarboxylate transport (GO:0015740)2.68584368
129regulation of dendritic spine morphogenesis (GO:0061001)2.68578070
130positive regulation of cardiac muscle cell differentiation (GO:2000727)2.62911174
131transmission of nerve impulse (GO:0019226)2.62315637
132dendrite morphogenesis (GO:0048813)2.57559238
133relaxation of cardiac muscle (GO:0055119)2.54955267
134retinal ganglion cell axon guidance (GO:0031290)2.52987933
135cell migration in hindbrain (GO:0021535)2.51063432
136cellular sodium ion homeostasis (GO:0006883)2.50937183
137cardiac chamber formation (GO:0003207)2.50428858
138membrane depolarization during action potential (GO:0086010)2.50344552
139regulation of sarcomere organization (GO:0060297)2.49304240
140cardiac muscle hypertrophy (GO:0003300)2.48368028
141synaptic vesicle maturation (GO:0016188)2.47177829
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46180516
143embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44901197
144positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.42733229
145central nervous system neuron axonogenesis (GO:0021955)2.42281785
146sodium ion export (GO:0071436)2.41814557
147establishment of mitochondrion localization (GO:0051654)2.41687973
148striated muscle hypertrophy (GO:0014897)2.40789728
149layer formation in cerebral cortex (GO:0021819)2.40308482
150vascular smooth muscle contraction (GO:0014829)2.39628674
151sarcomere organization (GO:0045214)2.36367471
152detection of calcium ion (GO:0005513)2.35183486
153cerebral cortex cell migration (GO:0021795)2.33840436
154negative regulation of hormone biosynthetic process (GO:0032353)2.33723288
155synapse assembly (GO:0007416)2.33301052
156regulation of synapse structural plasticity (GO:0051823)2.32619694
157neuromuscular synaptic transmission (GO:0007274)2.32202275
158regulation of synapse assembly (GO:0051963)2.31840008
159regulation of dendritic spine development (GO:0060998)2.30064418
160multicellular organismal signaling (GO:0035637)2.28957258
161positive regulation of synapse maturation (GO:0090129)2.27689135
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.27341188
163regulation of axon guidance (GO:1902667)2.25769184
164cardiac ventricle formation (GO:0003211)2.24724526
165positive regulation of synapse assembly (GO:0051965)2.24539243
166axon ensheathment in central nervous system (GO:0032291)2.23598848
167central nervous system myelination (GO:0022010)2.23598848
168establishment of nucleus localization (GO:0040023)2.22943795
169cellular potassium ion homeostasis (GO:0030007)2.22024832
170synapse organization (GO:0050808)2.21578427
171response to auditory stimulus (GO:0010996)2.20527786
172cardiac muscle contraction (GO:0060048)2.20503865
173righting reflex (GO:0060013)2.20496149
174regulation of membrane repolarization (GO:0060306)2.19992772
175regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.19007396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.57592305
2GBX2_23144817_ChIP-Seq_PC3_Human4.50753542
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.38511879
4TAF15_26573619_Chip-Seq_HEK293_Human3.14722915
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86215489
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.73517228
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.37220096
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35734248
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32703944
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.28514146
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.24410774
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17984381
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17130785
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.12989937
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06700260
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02533350
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02154233
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01413888
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.95459670
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94931840
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92580211
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.90969041
23* P300_19829295_ChIP-Seq_ESCs_Human1.90545450
24REST_21632747_ChIP-Seq_MESCs_Mouse1.87843606
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87298122
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.87020910
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85425110
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81119149
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80181288
30SMAD4_21799915_ChIP-Seq_A2780_Human1.78977706
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.78139785
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76030790
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76030790
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74539541
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72477013
36FUS_26573619_Chip-Seq_HEK293_Human1.71221554
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68039171
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62430987
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62051802
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61484516
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.60462052
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.59971079
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59774975
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57651967
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57465997
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.57443114
47ZNF274_21170338_ChIP-Seq_K562_Hela1.57340671
48EWS_26573619_Chip-Seq_HEK293_Human1.53789618
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.52865579
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.47235321
51BCAT_22108803_ChIP-Seq_LS180_Human1.46110019
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45185736
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45165719
54* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44796117
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.42694077
56* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.41865994
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41239550
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39463393
59VDR_22108803_ChIP-Seq_LS180_Human1.37797834
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36631387
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36629580
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36496767
63ER_23166858_ChIP-Seq_MCF-7_Human1.35282092
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34960927
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34955536
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.32570200
67AR_25329375_ChIP-Seq_VCAP_Human1.31866772
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31374167
69HTT_18923047_ChIP-ChIP_STHdh_Human1.31288539
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30410340
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30272675
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.29695110
73STAT3_23295773_ChIP-Seq_U87_Human1.28345075
74LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28216385
75RNF2_27304074_Chip-Seq_NSC_Mouse1.27483566
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27223247
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27043991
78IGF1R_20145208_ChIP-Seq_DFB_Human1.26873410
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.26724487
80* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26525764
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.26501580
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25755172
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25378469
84P53_22387025_ChIP-Seq_ESCs_Mouse1.25122846
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25034353
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24839519
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24703452
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.24628263
89AR_21572438_ChIP-Seq_LNCaP_Human1.23904366
90SOX9_26525672_Chip-Seq_HEART_Mouse1.21956352
91* TCF4_23295773_ChIP-Seq_U87_Human1.21344975
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20802307
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20438685
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19993308
95CBP_20019798_ChIP-Seq_JUKART_Human1.18791186
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18791186
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.18545130
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17690911
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17620606
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16207346
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15893299
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15718656
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15376006
104TP53_18474530_ChIP-ChIP_U2OS_Human1.15312697
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15167167
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.13443698
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12812978
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12510799
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11904278
110P300_18555785_Chip-Seq_ESCs_Mouse1.11556725
111AR_19668381_ChIP-Seq_PC3_Human1.10340492
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.09596790
113RUNX2_22187159_ChIP-Seq_PCA_Human1.09385772
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08910378
115* TCF4_22108803_ChIP-Seq_LS180_Human1.08826868
116* DROSHA_22980978_ChIP-Seq_HELA_Human1.08664273
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08514211
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08514211
119EZH2_27294783_Chip-Seq_NPCs_Mouse1.08250212
120STAT3_18555785_Chip-Seq_ESCs_Mouse1.07045311
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.06799764
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05063275
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04419748
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04419748
125TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04134040
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03813072
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.03447606
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03203228
129JUN_21703547_ChIP-Seq_K562_Human1.01946838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.07880438
2MP0005360_urolithiasis4.53848429
3MP0005085_abnormal_gallbladder_physiolo4.14409965
4MP0003880_abnormal_central_pattern4.11350866
5MP0005365_abnormal_bile_salt3.66627844
6MP0008875_abnormal_xenobiotic_pharmacok3.55333297
7MP0004859_abnormal_synaptic_plasticity2.94796154
8MP0003635_abnormal_synaptic_transmissio2.50495103
9MP0009046_muscle_twitch2.50470723
10MP0009745_abnormal_behavioral_response2.50156512
11MP0001968_abnormal_touch/_nociception2.40694046
12MP0002822_catalepsy2.25959317
13MP0002102_abnormal_ear_morphology2.25847733
14MP0000569_abnormal_digit_pigmentation2.25322523
15MP0010329_abnormal_lipoprotein_level2.24794866
16MP0002064_seizures2.23305435
17MP0002876_abnormal_thyroid_physiology2.21593113
18MP0003252_abnormal_bile_duct2.20391479
19MP0002736_abnormal_nociception_after2.14375693
20MP0009697_abnormal_copulation2.14068578
21MP0004145_abnormal_muscle_electrophysio2.13790037
22MP0004270_analgesia2.12051778
23MP0001188_hyperpigmentation2.11732167
24MP0002063_abnormal_learning/memory/cond2.11295373
25MP0002572_abnormal_emotion/affect_behav2.00477625
26MP0001486_abnormal_startle_reflex1.96953387
27MP0004215_abnormal_myocardial_fiber1.93883046
28MP0002272_abnormal_nervous_system1.89147620
29MP0005646_abnormal_pituitary_gland1.82391585
30MP0003283_abnormal_digestive_organ1.78052431
31MP0004084_abnormal_cardiac_muscle1.77150014
32MP0006276_abnormal_autonomic_nervous1.70735324
33MP0002735_abnormal_chemical_nociception1.69922142
34MP0003806_abnormal_nucleotide_metabolis1.67278652
35MP0003195_calcinosis1.67096599
36MP0002067_abnormal_sensory_capabilities1.64888019
37MP0002734_abnormal_mechanical_nocicepti1.63686251
38MP0005332_abnormal_amino_acid1.60762536
39MP0001501_abnormal_sleep_pattern1.56960327
40MP0003890_abnormal_embryonic-extraembry1.55153020
41MP0004142_abnormal_muscle_tone1.48200418
42MP0005084_abnormal_gallbladder_morpholo1.44703605
43MP0003868_abnormal_feces_composition1.43989456
44MP0001984_abnormal_olfaction1.42973756
45MP0005187_abnormal_penis_morphology1.40621706
46MP0004885_abnormal_endolymph1.39998471
47MP0003879_abnormal_hair_cell1.39522392
48MP0003787_abnormal_imprinting1.35063974
49MP0009780_abnormal_chondrocyte_physiolo1.31681713
50MP0005171_absent_coat_pigmentation1.31599892
51MP0001440_abnormal_grooming_behavior1.30043047
52MP0002557_abnormal_social/conspecific_i1.29928907
53MP0008775_abnormal_heart_ventricle1.29288327
54MP0004924_abnormal_behavior1.27942167
55MP0005386_behavior/neurological_phenoty1.27942167
56MP0003121_genomic_imprinting1.26122966
57MP0005083_abnormal_biliary_tract1.24428705
58MP0005423_abnormal_somatic_nervous1.23068048
59MP0002938_white_spotting1.22510153
60MP0003937_abnormal_limbs/digits/tail_de1.22440342
61MP0003136_yellow_coat_color1.21237515
62MP0002638_abnormal_pupillary_reflex1.20964030
63MP0004036_abnormal_muscle_relaxation1.19571406
64MP0004019_abnormal_vitamin_homeostasis1.18450161
65MP0005551_abnormal_eye_electrophysiolog1.16931192
66MP0001666_abnormal_nutrient_absorption1.14516868
67MP0002234_abnormal_pharynx_morphology1.14516805
68MP0000778_abnormal_nervous_system1.13830716
69MP0003119_abnormal_digestive_system1.12189128
70MP0001529_abnormal_vocalization1.11836281
71MP0001764_abnormal_homeostasis1.11188041
72MP0002184_abnormal_innervation1.08665688
73MP0000534_abnormal_ureter_morphology1.06910280
74MP0002118_abnormal_lipid_homeostasis1.06827295
75MP0003137_abnormal_impulse_conducting1.06660827
76MP0001485_abnormal_pinna_reflex1.06396397
77MP0009379_abnormal_foot_pigmentation1.05844710
78MP0001502_abnormal_circadian_rhythm1.04489000
79MP0004742_abnormal_vestibular_system1.03666810
80MP0005409_darkened_coat_color1.03660053
81MP0002233_abnormal_nose_morphology1.01605736
82MP0000751_myopathy1.00026263
83MP0005253_abnormal_eye_physiology0.98951517
84MP0005620_abnormal_muscle_contractility0.98021963
85MP0001905_abnormal_dopamine_level0.97219465
86MP0003385_abnormal_body_wall0.96179585
87MP0006292_abnormal_olfactory_placode0.95178688
88MP0002733_abnormal_thermal_nociception0.94203097
89MP0001299_abnormal_eye_distance/0.93693816
90MP0002752_abnormal_somatic_nervous0.92383992
91MP0003861_abnormal_nervous_system0.92000320
92MP0006072_abnormal_retinal_apoptosis0.91594862
93MP0001970_abnormal_pain_threshold0.91586052
94MP0008872_abnormal_physiological_respon0.90377425
95MP0000026_abnormal_inner_ear0.90293463
96MP0002066_abnormal_motor_capabilities/c0.90271447
97MP0003567_abnormal_fetal_cardiomyocyte0.90173037
98MP0000462_abnormal_digestive_system0.89133484
99MP0000537_abnormal_urethra_morphology0.87841213
100MP0003122_maternal_imprinting0.87534076
101MP0005535_abnormal_body_temperature0.86446452
102MP0001293_anophthalmia0.86194995
103MP0009250_abnormal_appendicular_skeleto0.86180625
104MP0002697_abnormal_eye_size0.85723116
105MP0000749_muscle_degeneration0.85516178
106MP0003755_abnormal_palate_morphology0.84916382
107MP0002909_abnormal_adrenal_gland0.84388513
108MP0008569_lethality_at_weaning0.84282611
109MP0000566_synostosis0.82040960
110MP0003633_abnormal_nervous_system0.81518375
111MP0003935_abnormal_craniofacial_develop0.81381628
112MP0008874_decreased_physiological_sensi0.80964862
113MP0000955_abnormal_spinal_cord0.79704909
114MP0001177_atelectasis0.79540864
115MP0010368_abnormal_lymphatic_system0.79077986
116MP0002972_abnormal_cardiac_muscle0.78398441
117MP0006035_abnormal_mitochondrial_morpho0.78261643
118MP0002837_dystrophic_cardiac_calcinosis0.76382711
119MP0004147_increased_porphyrin_level0.75255046
120MP0005584_abnormal_enzyme/coenzyme_acti0.74939945
121MP0004272_abnormal_basement_membrane0.74673491
122MP0002882_abnormal_neuron_morphology0.74495989
123MP0000427_abnormal_hair_cycle0.74153351
124MP0001963_abnormal_hearing_physiology0.73711308
125MP0004811_abnormal_neuron_physiology0.73349056
126MP0002229_neurodegeneration0.72251642
127MP0003631_nervous_system_phenotype0.72226912
128MP0005647_abnormal_sex_gland0.70239948
129MP0008877_abnormal_DNA_methylation0.70208085
130MP0000609_abnormal_liver_physiology0.69072086
131MP0002069_abnormal_eating/drinking_beha0.68198288
132MP0001986_abnormal_taste_sensitivity0.66667060
133MP0004381_abnormal_hair_follicle0.65576870
134MP0002138_abnormal_hepatobiliary_system0.63979523
135MP0003718_maternal_effect0.63363551
136MP0004085_abnormal_heartbeat0.61807990
137MP0005248_abnormal_Harderian_gland0.61286531
138MP0005645_abnormal_hypothalamus_physiol0.61257333
139MP0006036_abnormal_mitochondrial_physio0.61120164
140MP0000631_abnormal_neuroendocrine_gland0.60718395
141MP0002152_abnormal_brain_morphology0.60337480
142MP0002160_abnormal_reproductive_system0.59257156
143MP0003011_delayed_dark_adaptation0.58173947
144MP0005448_abnormal_energy_balance0.57913804
145MP0005319_abnormal_enzyme/_coenzyme0.57813276

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.00487706
2Hyperventilation (HP:0002883)5.46107186
3Prolonged partial thromboplastin time (HP:0003645)4.84834191
4Calf muscle hypertrophy (HP:0008981)4.71102741
5Intrahepatic cholestasis (HP:0001406)4.43563263
6Hypobetalipoproteinemia (HP:0003563)4.38438193
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32550234
8Muscle hypertrophy of the lower extremities (HP:0008968)4.28699811
9Type II lissencephaly (HP:0007260)4.20950124
10Febrile seizures (HP:0002373)4.16018382
11Deep venous thrombosis (HP:0002625)4.09877850
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.96399392
13Epileptic encephalopathy (HP:0200134)3.93463369
14Atonic seizures (HP:0010819)3.85350219
15Hyperglycinemia (HP:0002154)3.56527902
16Focal seizures (HP:0007359)3.36253265
17Abnormality of the calf musculature (HP:0001430)3.35458514
18Xanthomatosis (HP:0000991)3.19948302
19Abnormality of methionine metabolism (HP:0010901)3.16109963
20Fair hair (HP:0002286)3.13327636
21Retinal dysplasia (HP:0007973)3.12448037
22Hyperlipoproteinemia (HP:0010980)3.11855384
23Conjugated hyperbilirubinemia (HP:0002908)3.10387809
24Broad-based gait (HP:0002136)3.07224016
25Joint hemorrhage (HP:0005261)3.06347619
26Hypolipoproteinemia (HP:0010981)2.98920946
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.98715596
28Blue irides (HP:0000635)2.97449086
29Absence seizures (HP:0002121)2.97047810
30Status epilepticus (HP:0002133)2.89676813
31Epidermoid cyst (HP:0200040)2.87940653
32Complement deficiency (HP:0004431)2.86885160
33Cerebral edema (HP:0002181)2.82861819
34Dialeptic seizures (HP:0011146)2.81986161
35Gaze-evoked nystagmus (HP:0000640)2.81219802
36Abnormality of serum amino acid levels (HP:0003112)2.68019011
37Abnormality of the corticospinal tract (HP:0002492)2.66519431
38Abnormality of the ischium (HP:0003174)2.65201901
39Myokymia (HP:0002411)2.63470654
40Lissencephaly (HP:0001339)2.63413050
41Generalized tonic-clonic seizures (HP:0002069)2.59783229
42Action tremor (HP:0002345)2.59632377
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.59498356
44Abnormality of pyrimidine metabolism (HP:0004353)2.58960616
45Hyperammonemia (HP:0001987)2.56478555
46Cerebellar dysplasia (HP:0007033)2.55724950
47Generalized hypopigmentation of hair (HP:0011358)2.55123641
48Hyperglycinuria (HP:0003108)2.52101908
49Hepatoblastoma (HP:0002884)2.50531549
50Progressive cerebellar ataxia (HP:0002073)2.49542070
51Fat malabsorption (HP:0002630)2.46128525
52Abnormality of serine family amino acid metabolism (HP:0010894)2.42411299
53Abnormality of glycine metabolism (HP:0010895)2.42411299
54Progressive external ophthalmoplegia (HP:0000590)2.41352504
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.40385056
56Bundle branch block (HP:0011710)2.40314371
57Spontaneous abortion (HP:0005268)2.39521952
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38362073
59Ketosis (HP:0001946)2.37297127
60Atrial fibrillation (HP:0005110)2.36632729
61Sudden death (HP:0001699)2.32651216
62Hypoalphalipoproteinemia (HP:0003233)2.32650404
63Scanning speech (HP:0002168)2.32649621
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.31036147
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31036147
66Acute encephalopathy (HP:0006846)2.30552716
67Abnormal hair whorl (HP:0010721)2.30532703
68Protruding tongue (HP:0010808)2.29337954
69Abnormality of the common coagulation pathway (HP:0010990)2.28123189
70Morphological abnormality of the pyramidal tract (HP:0002062)2.27999092
71Lethargy (HP:0001254)2.27039117
72Chronic hepatic failure (HP:0100626)2.25786535
73Excessive salivation (HP:0003781)2.24724612
74Drooling (HP:0002307)2.24724612
75Hypochromic microcytic anemia (HP:0004840)2.24184259
76Hemiparesis (HP:0001269)2.23607308
77Pachygyria (HP:0001302)2.22955934
78Syncope (HP:0001279)2.20271560
79Poor suck (HP:0002033)2.18223196
80Acanthocytosis (HP:0001927)2.18048138
81Delayed CNS myelination (HP:0002188)2.17932365
82Epileptiform EEG discharges (HP:0011182)2.17809278
83Acute necrotizing encephalopathy (HP:0006965)2.17568548
84Cutaneous finger syndactyly (HP:0010554)2.16113862
85Bile duct proliferation (HP:0001408)2.15505367
86Abnormal biliary tract physiology (HP:0012439)2.15505367
87Abnormal gallbladder physiology (HP:0012438)2.15299446
88Cholecystitis (HP:0001082)2.15299446
89Limb dystonia (HP:0002451)2.13581241
90Primary atrial arrhythmia (HP:0001692)2.12307832
91Volvulus (HP:0002580)2.12251897
92Dysdiadochokinesis (HP:0002075)2.10390433
93Progressive macrocephaly (HP:0004481)2.07797129
94Abnormal mitochondria in muscle tissue (HP:0008316)2.07274394
95Gait imbalance (HP:0002141)2.04445947
96Thyroid-stimulating hormone excess (HP:0002925)2.01818046
97Enlarged kidneys (HP:0000105)2.01190702
98Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98492484
99Hypoplasia of the brainstem (HP:0002365)1.98492484
100Inability to walk (HP:0002540)1.98374829
101Hypercholesterolemia (HP:0003124)1.96770787
102Medial flaring of the eyebrow (HP:0010747)1.96651232
103Hypoplastic ischia (HP:0003175)1.96007548
104Abnormal social behavior (HP:0012433)1.94498325
105Impaired social interactions (HP:0000735)1.94498325
106Supraventricular tachycardia (HP:0004755)1.92824567
107Impaired vibratory sensation (HP:0002495)1.91341371
108Poor eye contact (HP:0000817)1.91238716
109Sensory axonal neuropathy (HP:0003390)1.90644390
110Pheochromocytoma (HP:0002666)1.90427548
111Congenital primary aphakia (HP:0007707)1.90284800
112EEG with generalized epileptiform discharges (HP:0011198)1.90264257
113Hyperbilirubinemia (HP:0002904)1.90192222
114Metabolic acidosis (HP:0001942)1.90108507
115Urinary bladder sphincter dysfunction (HP:0002839)1.89875269
116Optic disc pallor (HP:0000543)1.89374887
117Supraventricular arrhythmia (HP:0005115)1.88325801
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87484241
119Amblyopia (HP:0000646)1.87323148
120Abnormal ventriculo-arterial connection (HP:0011563)1.86979300
121Transposition of the great arteries (HP:0001669)1.86979300
122Abnormal connection of the cardiac segments (HP:0011545)1.86979300
123Megalencephaly (HP:0001355)1.86096750
124Genital tract atresia (HP:0001827)1.85813869
125Abnormality of the intrinsic pathway (HP:0010989)1.85792255
126Midline defect of the nose (HP:0004122)1.84938240
127Impaired vibration sensation in the lower limbs (HP:0002166)1.83834766
128Intestinal atresia (HP:0011100)1.83516215
129Subaortic stenosis (HP:0001682)1.83226112
130Abnormality of the left ventricular outflow tract (HP:0011103)1.83226112
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81517964
132Papillary thyroid carcinoma (HP:0002895)1.81413627
133Confusion (HP:0001289)1.81218268
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.80558191
135Poor coordination (HP:0002370)1.79015530
1363-Methylglutaconic aciduria (HP:0003535)1.78232556
137Hypsarrhythmia (HP:0002521)1.78189217
138Prolonged QT interval (HP:0001657)1.77255465
139Vaginal atresia (HP:0000148)1.76427048
140Left ventricular hypertrophy (HP:0001712)1.76375845
141Limited hip movement (HP:0008800)1.75820422
142Absent speech (HP:0001344)1.75775231
143Cutaneous syndactyly (HP:0012725)1.75260018
144Preaxial foot polydactyly (HP:0001841)1.75217670
145Anxiety (HP:0000739)1.74630435
146Abnormality of the lower motor neuron (HP:0002366)1.74593637
147Abnormality of the vitreous humor (HP:0004327)1.74405804
148Abnormality of complement system (HP:0005339)1.73538259
149Hepatocellular necrosis (HP:0001404)1.73376037
150Generalized myoclonic seizures (HP:0002123)1.72914416
151Delayed myelination (HP:0012448)1.72888525
152Nephronophthisis (HP:0000090)1.72810079
153Abnormality of the pubic bones (HP:0003172)1.71864066
154Anophthalmia (HP:0000528)1.70845729
155Optic nerve hypoplasia (HP:0000609)1.69723183
156Absent eyebrow (HP:0002223)1.68994074
157Chorioretinal atrophy (HP:0000533)1.67688903
158Partial agenesis of the corpus callosum (HP:0001338)1.64812465
159Thickened helices (HP:0000391)1.64799795
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.63697232
161Oligodactyly (hands) (HP:0001180)1.63671568
162Polyphagia (HP:0002591)1.62608677
163Genetic anticipation (HP:0003743)1.62280166
164Vitreoretinal degeneration (HP:0000655)1.61800266
165Renal hypoplasia (HP:0000089)1.58878822
166Abnormality of midbrain morphology (HP:0002418)1.58462281
167Molar tooth sign on MRI (HP:0002419)1.58462281
168Urinary urgency (HP:0000012)1.56055008
169Abnormality of the labia minora (HP:0012880)1.55883810
170Short tibia (HP:0005736)1.55853568
171True hermaphroditism (HP:0010459)1.55794743
172Pancreatic fibrosis (HP:0100732)1.54948904
173Neuroendocrine neoplasm (HP:0100634)1.54305344
174Meningocele (HP:0002435)1.54091580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.25296612
2AKT33.65250137
3MAP2K73.19130558
4NTRK33.03489785
5EPHA43.03471262
6OBSCN2.99217444
7MAP3K42.69668695
8MAP2K42.28866503
9DAPK22.23822800
10MAP3K122.16770442
11CCNB12.15164769
12MARK12.13319476
13PRPF4B2.00134816
14CDK191.94763550
15SGK21.84840793
16PLK21.77441509
17INSRR1.70608724
18TNIK1.69674237
19PHKG21.56655522
20PHKG11.56655522
21MAPK131.53363777
22SGK2231.50705597
23SGK4941.50705597
24LATS11.44454851
25OXSR11.40044254
26STK391.38641431
27NTRK21.37021699
28DAPK11.35139998
29ERBB41.35006884
30ACVR1B1.32107444
31PINK11.23275319
32MKNK21.18605214
33BCKDK1.18042632
34SIK31.14800765
35SGK31.14612216
36MINK11.14312027
37PRKCG1.13203061
38PKN21.10951732
39EPHB21.10877192
40WNK41.10741194
41STK161.10133917
42CAMK2A1.05539974
43CAMK2B1.02996315
44FRK1.02472800
45PAK31.00307628
46DMPK0.99574166
47ERBB30.99332286
48CAMK1G0.99078826
49DYRK20.95601800
50GRK50.92253552
51NTRK10.91387005
52LATS20.90853439
53BRAF0.89295901
54BMPR1B0.89027576
55BMPR20.88948701
56MET0.84745628
57MUSK0.81444548
58TLK10.81376434
59TSSK60.80740001
60MAPK70.80116965
61CDK30.77268894
62FGFR20.77184548
63PKN10.76661107
64TYRO30.76519784
65BRD40.76406125
66MAPK120.76267534
67PDK30.75621323
68PDK40.75621323
69SIK20.74626535
70CDK50.74515944
71CAMK2G0.73006254
72FES0.72976456
73NEK60.72288979
74TIE10.69900713
75GRK10.69875935
76PRKCE0.69731535
77SRPK10.68209510
78TRIM280.68173188
79CAMKK20.68001547
80YES10.67695641
81PNCK0.67058213
82MAP3K100.66376262
83WNK30.66146578
84PRKD30.65667987
85CSNK1G20.65401881
86WEE10.65082829
87BCR0.64588489
88CAMK10.63314625
89STK38L0.62981709
90STK110.62550200
91MAP3K90.61351530
92ADRBK20.60585065
93FLT30.59854535
94PTK2B0.58234894
95CAMK40.57149771
96PAK60.55456132
97ROCK10.54971458
98CAMKK10.54496248
99CAMK2D0.52249045
100DYRK1A0.51988544
101IRAK20.51857237
102FGFR10.51726230
103SGK10.51478486
104PRKAA10.49521795
105NUAK10.48568592
106KSR10.48440067
107PDK20.47425493
108ZAK0.46877269
109CSNK1G10.46850527
110CSNK1E0.46482992
111NEK90.46421715
112STK30.46185664
113PIK3CA0.44534865
114PRKACA0.44498254
115DYRK30.44473964
116STK380.44037423
117PRKCZ0.43970398
118CSNK1G30.43595806
119CDK11A0.42339233
120WNK10.42258518
121PBK0.42040014
122RIPK40.41964853
123CDK80.41739372
124FER0.40860518
125MAPK40.40111589
126PRKCH0.38960276
127CSNK1D0.38270990
128PRKG10.35027335
129RPS6KB10.34896488
130MYLK0.34638310
131ADRBK10.34029320
132GRK70.32617276
133UHMK10.31752510
134CDK180.28832375
135CSNK1A1L0.28638190
136PRKCA0.28381832
137SIK10.28203901
138RPS6KA30.27647391

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.64964584
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38417655
3Arginine biosynthesis_Homo sapiens_hsa002202.88151844
4Nicotine addiction_Homo sapiens_hsa050332.81854585
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68453844
6Nitrogen metabolism_Homo sapiens_hsa009102.52651113
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39691922
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33468319
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18466163
10Butanoate metabolism_Homo sapiens_hsa006502.16609619
11Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.05416141
12Tryptophan metabolism_Homo sapiens_hsa003801.97018366
13Complement and coagulation cascades_Homo sapiens_hsa046101.90698894
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89290539
15Cardiac muscle contraction_Homo sapiens_hsa042601.89113735
16Synaptic vesicle cycle_Homo sapiens_hsa047211.82674004
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.79726282
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78346548
19Dilated cardiomyopathy_Homo sapiens_hsa054141.77302187
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67526969
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.60698053
22Peroxisome_Homo sapiens_hsa041461.60548774
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60209330
24GABAergic synapse_Homo sapiens_hsa047271.58121466
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57915202
26Propanoate metabolism_Homo sapiens_hsa006401.56926908
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55090621
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54871033
29Fatty acid degradation_Homo sapiens_hsa000711.52502180
30Pyruvate metabolism_Homo sapiens_hsa006201.49419269
31Fatty acid elongation_Homo sapiens_hsa000621.48872153
32beta-Alanine metabolism_Homo sapiens_hsa004101.47668157
33Phenylalanine metabolism_Homo sapiens_hsa003601.46197380
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41560693
35Morphine addiction_Homo sapiens_hsa050321.39476588
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37733361
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37033040
38Retinol metabolism_Homo sapiens_hsa008301.36882745
39Hedgehog signaling pathway_Homo sapiens_hsa043401.36656470
40Histidine metabolism_Homo sapiens_hsa003401.34170527
41Chemical carcinogenesis_Homo sapiens_hsa052041.33033762
42Tyrosine metabolism_Homo sapiens_hsa003501.31555178
43Bile secretion_Homo sapiens_hsa049761.31256891
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28404561
45Glutamatergic synapse_Homo sapiens_hsa047241.27391330
46Fatty acid metabolism_Homo sapiens_hsa012121.26619021
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23864507
48Circadian rhythm_Homo sapiens_hsa047101.23494136
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.23396234
50Basal cell carcinoma_Homo sapiens_hsa052171.23347105
51Circadian entrainment_Homo sapiens_hsa047131.22958149
52Hippo signaling pathway_Homo sapiens_hsa043901.22666960
53Collecting duct acid secretion_Homo sapiens_hsa049661.19224377
54PPAR signaling pathway_Homo sapiens_hsa033201.17734289
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15537848
56Amphetamine addiction_Homo sapiens_hsa050311.14006626
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10335699
58Taste transduction_Homo sapiens_hsa047421.09109033
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06126113
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.02542858
61Vitamin B6 metabolism_Homo sapiens_hsa007501.02477526
62Dorso-ventral axis formation_Homo sapiens_hsa043201.01594438
63Gap junction_Homo sapiens_hsa045400.99010583
64Olfactory transduction_Homo sapiens_hsa047400.98135039
65Gastric acid secretion_Homo sapiens_hsa049710.97988848
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95862096
67Long-term potentiation_Homo sapiens_hsa047200.93413816
68Protein digestion and absorption_Homo sapiens_hsa049740.90416617
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89936855
70Oxidative phosphorylation_Homo sapiens_hsa001900.89232010
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88770752
72Vitamin digestion and absorption_Homo sapiens_hsa049770.87178476
73Melanogenesis_Homo sapiens_hsa049160.85816039
74ABC transporters_Homo sapiens_hsa020100.85485469
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85366722
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81156034
77Insulin secretion_Homo sapiens_hsa049110.80128018
78Biosynthesis of amino acids_Homo sapiens_hsa012300.80096840
79Serotonergic synapse_Homo sapiens_hsa047260.79229175
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.79068505
81Pancreatic secretion_Homo sapiens_hsa049720.78654940
82Carbon metabolism_Homo sapiens_hsa012000.77973037
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77896903
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76462149
85Sulfur metabolism_Homo sapiens_hsa009200.76418396
86Starch and sucrose metabolism_Homo sapiens_hsa005000.75844834
87Tight junction_Homo sapiens_hsa045300.75772218
88TGF-beta signaling pathway_Homo sapiens_hsa043500.75552715
89Salivary secretion_Homo sapiens_hsa049700.75412482
90Dopaminergic synapse_Homo sapiens_hsa047280.74787267
91Wnt signaling pathway_Homo sapiens_hsa043100.73986056
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.73896997
93Thyroid hormone synthesis_Homo sapiens_hsa049180.73484898
94Phototransduction_Homo sapiens_hsa047440.72637522
95Caffeine metabolism_Homo sapiens_hsa002320.72112529
96Linoleic acid metabolism_Homo sapiens_hsa005910.71652156
97Fat digestion and absorption_Homo sapiens_hsa049750.70673982
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68499244
99Long-term depression_Homo sapiens_hsa047300.68463095
100Renin secretion_Homo sapiens_hsa049240.68108515
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64556596
102Oocyte meiosis_Homo sapiens_hsa041140.64088795
103Calcium signaling pathway_Homo sapiens_hsa040200.63534036
104Steroid biosynthesis_Homo sapiens_hsa001000.62082938
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59743881
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59724484
107Staphylococcus aureus infection_Homo sapiens_hsa051500.58111759
108Type II diabetes mellitus_Homo sapiens_hsa049300.57989455
109Arginine and proline metabolism_Homo sapiens_hsa003300.55940540
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55558174
111Basal transcription factors_Homo sapiens_hsa030220.54388968
112Alcoholism_Homo sapiens_hsa050340.53193663
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.52901456
114Selenocompound metabolism_Homo sapiens_hsa004500.51583165
115Mineral absorption_Homo sapiens_hsa049780.51345299
116Cocaine addiction_Homo sapiens_hsa050300.51324765
117Estrogen signaling pathway_Homo sapiens_hsa049150.50119422
118Metabolic pathways_Homo sapiens_hsa011000.47253940
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46697742
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46583377
121ECM-receptor interaction_Homo sapiens_hsa045120.46428085
122Alzheimers disease_Homo sapiens_hsa050100.45492101
123Glycerolipid metabolism_Homo sapiens_hsa005610.44262106
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44147414
125Parkinsons disease_Homo sapiens_hsa050120.43040290
126Cholinergic synapse_Homo sapiens_hsa047250.42368738
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40843788
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39140262
129Vibrio cholerae infection_Homo sapiens_hsa051100.38091730
130Glucagon signaling pathway_Homo sapiens_hsa049220.37779405
131Lysine degradation_Homo sapiens_hsa003100.34742307
132Axon guidance_Homo sapiens_hsa043600.31553496
133cAMP signaling pathway_Homo sapiens_hsa040240.30596455
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30489094
135Fatty acid biosynthesis_Homo sapiens_hsa000610.29922964
136Oxytocin signaling pathway_Homo sapiens_hsa049210.28652080
137Huntingtons disease_Homo sapiens_hsa050160.26258454
138Ovarian steroidogenesis_Homo sapiens_hsa049130.26062117
139Folate biosynthesis_Homo sapiens_hsa007900.23788250

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