DENND5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DENN-domain-containing protein that functions as a RAB-activating guanine nucleotide exchange factor (GEF). This protein catalyzes the conversion of GDP to GTP and thereby converts inactive GDP-bound Rab proteins into their active GTP-bound form. The encoded protein is recruited by RAB6 onto Golgi membranes and is therefore referred to as RAB6-interacting protein 1. This protein binds with RAB39 as well. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene are associated with early infantile epileptic encephalopathy-49. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.77011688
2locomotory exploration behavior (GO:0035641)4.69169384
3response to peptidoglycan (GO:0032494)4.54954442
4positive regulation by symbiont of host defense response (GO:0052509)4.33632632
5modulation by symbiont of host defense response (GO:0052031)4.33632632
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.33632632
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.33632632
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.33632632
9modulation by symbiont of host immune response (GO:0052553)4.33632632
10detection of molecule of bacterial origin (GO:0032490)4.28057525
11negative regulation of interleukin-12 production (GO:0032695)4.19996849
12positive regulation of gamma-delta T cell activation (GO:0046645)4.10787632
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.06934277
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03495945
15macrophage activation involved in immune response (GO:0002281)3.99704082
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98234404
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92705109
18negative regulation of cell killing (GO:0031342)3.92705109
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79966474
20regulation of synapse structural plasticity (GO:0051823)3.69263698
21response to muramyl dipeptide (GO:0032495)3.63253864
22layer formation in cerebral cortex (GO:0021819)3.58629197
23sodium ion export (GO:0071436)3.58476256
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57352089
25L-amino acid import (GO:0043092)3.56367415
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55911797
27regulation of synaptic vesicle exocytosis (GO:2000300)3.55859195
28cellular extravasation (GO:0045123)3.55149069
29vocalization behavior (GO:0071625)3.52056976
30lipopolysaccharide-mediated signaling pathway (GO:0031663)3.48027670
31cellular potassium ion homeostasis (GO:0030007)3.47289337
32negative regulation of erythrocyte differentiation (GO:0045647)3.45817567
33central nervous system myelination (GO:0022010)3.43002423
34axon ensheathment in central nervous system (GO:0032291)3.43002423
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.33794698
36glycine transport (GO:0015816)3.28325173
37neuronal action potential propagation (GO:0019227)3.28000257
38synaptic vesicle exocytosis (GO:0016079)3.27912176
39germinal center formation (GO:0002467)3.27239792
40detection of other organism (GO:0098543)3.26861279
41regulation of glutamate receptor signaling pathway (GO:1900449)3.26289720
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.24381578
43detection of external biotic stimulus (GO:0098581)3.22989777
44potassium ion import (GO:0010107)3.20687085
45regulation of macrophage cytokine production (GO:0010935)3.18319583
46positive regulation of cellular amide metabolic process (GO:0034250)3.17764078
47dendritic spine morphogenesis (GO:0060997)3.16493660
48glutamate secretion (GO:0014047)3.15986985
49regulation of T-helper 2 cell differentiation (GO:0045628)3.15853148
50neutrophil activation involved in immune response (GO:0002283)3.15647445
51activation of protein kinase A activity (GO:0034199)3.13646922
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13329817
53regulation of synaptic vesicle transport (GO:1902803)3.12330928
54macrophage activation (GO:0042116)3.12058775
55establishment of nucleus localization (GO:0040023)3.11087824
56regulation of neuronal synaptic plasticity (GO:0048168)3.10647604
57neuromuscular process controlling balance (GO:0050885)3.06021742
58detection of biotic stimulus (GO:0009595)3.02586620
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02042202
60exploration behavior (GO:0035640)3.01730727
61regulation of interferon-beta biosynthetic process (GO:0045357)3.01619853
62nerve growth factor signaling pathway (GO:0038180)3.01503954
63microglial cell activation (GO:0001774)2.99579459
64dendrite morphogenesis (GO:0048813)2.97123720
65regulation of ARF protein signal transduction (GO:0032012)2.95711432
66leukocyte aggregation (GO:0070486)2.93804276
67regulation of dendritic spine morphogenesis (GO:0061001)2.93183710
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92643966
69response to host immune response (GO:0052572)2.92643966
70neutrophil mediated immunity (GO:0002446)2.90468160
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88381242
72gamma-aminobutyric acid transport (GO:0015812)2.87977740
73cytoskeletal anchoring at plasma membrane (GO:0007016)2.86974072
74neurotransmitter secretion (GO:0007269)2.86810622
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.86551762
76response to host (GO:0075136)2.86551762
77response to host defenses (GO:0052200)2.86551762
78cell communication by electrical coupling (GO:0010644)2.86279497
79long-term memory (GO:0007616)2.81447714
80regulation of gamma-delta T cell activation (GO:0046643)2.81083941
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.80355461
82neuron cell-cell adhesion (GO:0007158)2.79851888
83amino acid import (GO:0043090)2.79406448
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.78236838
85neuronal ion channel clustering (GO:0045161)2.76940246
86vesicle transport along microtubule (GO:0047496)2.76607165
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76006916
88synaptic transmission, glutamatergic (GO:0035249)2.75084895
89regulation of voltage-gated calcium channel activity (GO:1901385)2.74417317
90glutamate receptor signaling pathway (GO:0007215)2.74122671
91prepulse inhibition (GO:0060134)2.74097990
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.73404955
93detection of bacterium (GO:0016045)2.72272377
94neurotransmitter-gated ion channel clustering (GO:0072578)2.72132211
95cerebellar Purkinje cell differentiation (GO:0021702)2.68915092
96regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68593458
97potassium ion homeostasis (GO:0055075)2.68497203
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67725449
99T-helper 1 type immune response (GO:0042088)2.67508056
100myelination (GO:0042552)2.67124009
101adult walking behavior (GO:0007628)2.67022383
102axon ensheathment (GO:0008366)2.65439810
103ensheathment of neurons (GO:0007272)2.65439810
104positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65336665
105regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.65251516
106adenosine receptor signaling pathway (GO:0001973)2.65095563
107regulation of vitamin D biosynthetic process (GO:0060556)2.64341398
108positive regulation of type 2 immune response (GO:0002830)2.64120588
109protein localization to synapse (GO:0035418)2.62910907
110cerebellar granule cell differentiation (GO:0021707)2.62541875
111negative regulation of cytokine production involved in immune response (GO:0002719)2.62361324
112mating behavior (GO:0007617)2.61050245
113transmission of nerve impulse (GO:0019226)2.60562169
114neuron-neuron synaptic transmission (GO:0007270)2.60020284
115negative regulation of toll-like receptor signaling pathway (GO:0034122)2.59380441
116regulation of leukocyte degranulation (GO:0043300)2.59380437
117positive regulation of receptor recycling (GO:0001921)2.59173485
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59165150
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58709167
120auditory behavior (GO:0031223)2.58612417
121neutrophil activation (GO:0042119)2.58085706
122clathrin coat assembly (GO:0048268)2.57938961
123regulation of mast cell degranulation (GO:0043304)2.57637681
124negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56341295
125regulation of B cell receptor signaling pathway (GO:0050855)2.56274186
126granulocyte activation (GO:0036230)2.56040086
127negative regulation of protein localization to cell surface (GO:2000009)2.55808238
128regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.55158392
129negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54897173
130regulation of ARF GTPase activity (GO:0032312)2.53556892
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.52376762
132protein localization to endosome (GO:0036010)2.52057829
133response to auditory stimulus (GO:0010996)2.51747387
134regulation of postsynaptic membrane potential (GO:0060078)2.51473262
135regulation of type 2 immune response (GO:0002828)2.50714923
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49928857
137myeloid leukocyte mediated immunity (GO:0002444)2.49080941
138regulation of synaptic plasticity (GO:0048167)2.48725533
139cortical actin cytoskeleton organization (GO:0030866)2.48654312
140negative regulation of type 2 immune response (GO:0002829)2.48606407
141response to laminar fluid shear stress (GO:0034616)2.47669219
142production of molecular mediator involved in inflammatory response (GO:0002532)2.47017432
143cellular response to type I interferon (GO:0071357)2.46808172
144type I interferon signaling pathway (GO:0060337)2.46808172
145positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46284530
146stress fiber assembly (GO:0043149)2.45605581
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.45198632
148membrane depolarization during action potential (GO:0086010)2.45098362
149myeloid cell activation involved in immune response (GO:0002275)2.44411183
150regulation of dendritic spine development (GO:0060998)2.44231094
151negative regulation of lymphocyte mediated immunity (GO:0002707)2.43479107
152synaptic vesicle endocytosis (GO:0048488)2.43324110
153response to type I interferon (GO:0034340)2.42638026
154negative regulation of T cell mediated immunity (GO:0002710)2.42605498
155long-term synaptic potentiation (GO:0060291)2.42201544
156antigen processing and presentation of endogenous antigen (GO:0019883)2.42180609
157neuron recognition (GO:0008038)2.41583221
158regulation of T-helper 1 cell differentiation (GO:0045625)2.41334934
159neuromuscular process controlling posture (GO:0050884)2.40708058
160regulation of neurotransmitter secretion (GO:0046928)2.40390991
161neutrophil chemotaxis (GO:0030593)2.39996720
162positive regulation of membrane potential (GO:0045838)2.39830685
163positive regulation of potassium ion transport (GO:0043268)2.38661105
164proline transport (GO:0015824)2.38455186
165axonal fasciculation (GO:0007413)2.37597191
166regulation of toll-like receptor signaling pathway (GO:0034121)2.37437947
167JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37308542
168regulation of mast cell activation involved in immune response (GO:0033006)2.36717420
169regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.36269686
170defense response to protozoan (GO:0042832)2.36032156
171regulation of tolerance induction (GO:0002643)2.36011858
172membrane hyperpolarization (GO:0060081)2.35803880
173regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.35660507
174positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.35383723
175neurotransmitter transport (GO:0006836)2.35382637
176cellular sodium ion homeostasis (GO:0006883)2.35304585
177positive regulation of macrophage cytokine production (GO:0060907)2.34697503
178negative regulation of leukocyte mediated immunity (GO:0002704)2.34550966
179regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.34464076
180negative regulation of neurotransmitter transport (GO:0051589)2.34305487
181negative regulation of interleukin-17 production (GO:0032700)2.33539448
182antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33424222
183neutrophil migration (GO:1990266)2.32835999
184positive regulation of toll-like receptor signaling pathway (GO:0034123)2.32775522
185cellular response to epinephrine stimulus (GO:0071872)2.31439194
186positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28751644
187regulation of interferon-alpha production (GO:0032647)2.27078149
188leukocyte migration involved in inflammatory response (GO:0002523)2.26832740
189interferon-gamma-mediated signaling pathway (GO:0060333)2.24974265
190regulation of T cell tolerance induction (GO:0002664)2.23721414
191cellular response to ethanol (GO:0071361)2.23430420
192positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.22770942
193negative regulation of production of molecular mediator of immune response (GO:0002701)2.22445645
194positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.21372556
195regulation of interleukin-12 biosynthetic process (GO:0045075)2.21049972
196positive regulation of interferon-alpha production (GO:0032727)2.20836144

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.95171839
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.73260952
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.30747501
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.20427024
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.90828821
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73096891
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64518750
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60112707
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.56699403
10DROSHA_22980978_ChIP-Seq_HELA_Human2.49711562
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49003902
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.48539085
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48282502
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43147276
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43147276
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41593037
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40312114
18GBX2_23144817_ChIP-Seq_PC3_Human2.37692812
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33098315
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25931513
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22306029
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.17530634
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16619740
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15361074
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11581646
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09958990
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07887006
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07350109
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03160002
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.94142047
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.89384783
32SPI1_23127762_ChIP-Seq_K562_Human1.89189431
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86569427
34TCF7_22412390_ChIP-Seq_EML_Mouse1.86168570
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.85476636
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82929665
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82237527
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.82153102
39VDR_24787735_ChIP-Seq_THP-1_Human1.81880212
40* RUNX_20019798_ChIP-Seq_JUKART_Human1.81180699
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78313772
42VDR_24763502_ChIP-Seq_THP-1_Human1.76674393
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.72456426
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70694229
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65659119
46REST_21632747_ChIP-Seq_MESCs_Mouse1.64561920
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63659533
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62367054
49AR_21572438_ChIP-Seq_LNCaP_Human1.60684943
50VDR_21846776_ChIP-Seq_THP-1_Human1.59877762
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58831248
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54723761
53SCL_19346495_ChIP-Seq_HPC-7_Human1.53417406
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53113665
55KDM2B_26808549_Chip-Seq_K562_Human1.52475407
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49978900
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47844588
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47731347
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.43073466
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42708875
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41484465
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40667248
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40634836
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39395582
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.38810090
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35948023
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.35000315
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.34427278
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.34093700
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.33697578
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32833163
72GATA1_22025678_ChIP-Seq_K562_Human1.32795191
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30747212
74PU_27001747_Chip-Seq_BMDM_Mouse1.30067667
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30062664
76RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29641776
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29199621
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.27806465
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27468986
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26917897
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26354448
82* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25920649
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25765100
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25280010
85SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24523047
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23413742
87* MAF_26560356_Chip-Seq_TH1_Human1.22546815
88TP53_16413492_ChIP-PET_HCT116_Human1.22182107
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21395683
90SMAD4_21799915_ChIP-Seq_A2780_Human1.20451556
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18685957
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.18031772
93AHR_22903824_ChIP-Seq_MCF-7_Human1.17682812
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.17393273
95CLOCK_20551151_ChIP-Seq_293T_Human1.16410123
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16357070
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15622105
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15288968
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14517694
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13461349
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.13297906
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13110986
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.12700895
104SPI1_23547873_ChIP-Seq_NB4_Human1.12415046
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12200981
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11142598
107AR_19668381_ChIP-Seq_PC3_Human1.09807050
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09674670
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09651198
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.09469983
111TBX20_22080862_ChIP-Seq_HEART_Mouse1.09469983
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09212841
113GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08932323
114MYC_22102868_ChIP-Seq_BL_Human1.08701961
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08655409
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.07829842
117STAT3_23295773_ChIP-Seq_U87_Human1.07229539
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06332622
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05677696
120NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05274932
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04125535
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.03192826
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02983677
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02755539
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.02344525
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02283598
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02005373
128UTX_26944678_Chip-Seq_JUKART_Human1.01950382
129* KDM2B_26808549_Chip-Seq_DND41_Human1.01421789
130ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00575614
131* KDM2B_26808549_Chip-Seq_JURKAT_Human0.99889207
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.98663355
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.98583194
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.98064859
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97714955
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97638651
137RXR_22108803_ChIP-Seq_LS180_Human0.97161598
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96720776
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96448116
140MYB_26560356_Chip-Seq_TH2_Human0.96438145
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94872415
142GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94552259
143* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94388448
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93105079
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.92224638
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91907531
147* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91706767
148* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91594696
149LXR_22292898_ChIP-Seq_THP-1_Human0.90569425
150TCF4_23295773_ChIP-Seq_U87_Human0.90514850
151ESR2_21235772_ChIP-Seq_MCF-7_Human0.90221638
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.89935563
153ZNF274_21170338_ChIP-Seq_K562_Hela0.89850766
154SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89335527
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88969338
156NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88560417
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87982772
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87930520
159GATA2_19941826_ChIP-Seq_K562_Human0.87654813
160GATA1_19941826_ChIP-Seq_K562_Human0.87452917
161PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87081230
162P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86387566
163NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84055116
164NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84055116
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83996712
166FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83945647
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83399114
168SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83146866
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80854838
170SMC1_22415368_ChIP-Seq_MEFs_Mouse0.79937150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.55718152
2MP0003724_increased_susceptibility_to4.05942642
3MP0003436_decreased_susceptibility_to3.48058711
4MP0003635_abnormal_synaptic_transmissio3.38370196
5MP0003880_abnormal_central_pattern3.20853232
6MP0004270_analgesia2.96936440
7MP0009046_muscle_twitch2.76293775
8MP0002064_seizures2.71745550
9MP0003705_abnormal_hypodermis_morpholog2.68789044
10MP0009745_abnormal_behavioral_response2.68205923
11MP0000920_abnormal_myelination2.63387958
12MP0002063_abnormal_learning/memory/cond2.57107040
13MP0002419_abnormal_innate_immunity2.48727495
14MP0001486_abnormal_startle_reflex2.41736278
15MP0009278_abnormal_bone_marrow2.40427021
16MP0001835_abnormal_antigen_presentation2.35876397
17MP0006082_CNS_inflammation2.33623348
18MP0002272_abnormal_nervous_system2.33586807
19MP0003690_abnormal_glial_cell2.30854202
20MP0003828_pulmonary_edema2.28109525
21MP0005623_abnormal_meninges_morphology2.24391620
22MP0005423_abnormal_somatic_nervous2.15254136
23MP0004885_abnormal_endolymph2.10439404
24MP0008260_abnormal_autophagy2.09827539
25MP0002822_catalepsy2.09795765
26MP0008569_lethality_at_weaning2.09787824
27MP0005167_abnormal_blood-brain_barrier2.07057014
28MP0005000_abnormal_immune_tolerance2.07049636
29MP0009785_altered_susceptibility_to2.05859126
30MP0002572_abnormal_emotion/affect_behav2.02961917
31MP0001533_abnormal_skeleton_physiology2.02719809
32MP0005025_abnormal_response_to1.94281059
33MP0002148_abnormal_hypersensitivity_rea1.93142176
34MP0000569_abnormal_digit_pigmentation1.92558883
35MP0003329_amyloid_beta_deposits1.90502427
36MP0004858_abnormal_nervous_system1.89436956
37MP0002734_abnormal_mechanical_nocicepti1.80431126
38MP0001501_abnormal_sleep_pattern1.75919538
39MP0009780_abnormal_chondrocyte_physiolo1.75502134
40MP0003191_abnormal_cellular_cholesterol1.74634385
41MP0000751_myopathy1.71214091
42MP0003634_abnormal_glial_cell1.71024187
43MP0002998_abnormal_bone_remodeling1.69815426
44MP0001968_abnormal_touch/_nociception1.68174273
45MP0006054_spinal_hemorrhage1.66158904
46MP0005387_immune_system_phenotype1.64800762
47MP0001790_abnormal_immune_system1.64800762
48MP0003279_aneurysm1.63779442
49MP0002723_abnormal_immune_serum1.62871681
50MP0000778_abnormal_nervous_system1.62320170
51MP0005171_absent_coat_pigmentation1.61865170
52MP0002452_abnormal_antigen_presenting1.60099288
53MP0003633_abnormal_nervous_system1.60033678
54MP0009764_decreased_sensitivity_to1.59361163
55MP0001800_abnormal_humoral_immune1.59167737
56MP0004947_skin_inflammation1.58501058
57MP0008004_abnormal_stomach_pH1.58301750
58MP0002067_abnormal_sensory_capabilities1.55924510
59MP0000685_abnormal_immune_system1.55407067
60MP0001440_abnormal_grooming_behavior1.50455252
61MP0005451_abnormal_body_composition1.50020282
62MP0003448_altered_tumor_morphology1.48283381
63MP0004811_abnormal_neuron_physiology1.47064129
64MP0002420_abnormal_adaptive_immunity1.46937609
65MP0001819_abnormal_immune_cell1.46033839
66MP0000955_abnormal_spinal_cord1.46006996
67MP0000343_altered_response_to1.42405579
68MP0001545_abnormal_hematopoietic_system1.42243211
69MP0005397_hematopoietic_system_phenotyp1.42243211
70MP0001970_abnormal_pain_threshold1.42203604
71MP0002332_abnormal_exercise_endurance1.42002602
72MP0004084_abnormal_cardiac_muscle1.41755618
73MP0003045_fibrosis1.41637669
74MP0002909_abnormal_adrenal_gland1.40829424
75MP0003631_nervous_system_phenotype1.40255264
76MP0004510_myositis1.39697283
77MP0004924_abnormal_behavior1.37711309
78MP0005386_behavior/neurological_phenoty1.37711309
79MP0003075_altered_response_to1.36561749
80MP0002405_respiratory_system_inflammati1.35693184
81MP0003632_abnormal_nervous_system1.31125588
82MP0005464_abnormal_platelet_physiology1.29830555
83MP0002733_abnormal_thermal_nociception1.29380526
84MP0005164_abnormal_response_to1.26131113
85MP0002882_abnormal_neuron_morphology1.26068284
86MP0003566_abnormal_cell_adhesion1.25810193
87MP0002066_abnormal_motor_capabilities/c1.25020932
88MP0004036_abnormal_muscle_relaxation1.24690066
89MP0004145_abnormal_muscle_electrophysio1.24611288
90MP0001958_emphysema1.24001609
91MP0000013_abnormal_adipose_tissue1.23921001
92MP0005076_abnormal_cell_differentiation1.23363557
93MP0004742_abnormal_vestibular_system1.22435155
94MP0002184_abnormal_innervation1.21912846
95MP0003172_abnormal_lysosome_physiology1.21702807
96MP0005166_decreased_susceptibility_to1.19628361
97MP0002557_abnormal_social/conspecific_i1.18663361
98MP0000767_abnormal_smooth_muscle1.16347010
99MP0000858_altered_metastatic_potential1.15910882
100MP0004215_abnormal_myocardial_fiber1.15603009
101MP0001177_atelectasis1.15571495
102MP0005671_abnormal_response_to1.15187115
103MP0001851_eye_inflammation1.10943259
104MP0004808_abnormal_hematopoietic_stem1.10594961
105MP0004130_abnormal_muscle_cell1.09881823
106MP0005390_skeleton_phenotype1.09685138
107MP0001845_abnormal_inflammatory_respons1.09020048
108MP0002736_abnormal_nociception_after1.08405164
109MP0004085_abnormal_heartbeat1.08119478
110MP0003303_peritoneal_inflammation1.05480132
111MP0008438_abnormal_cutaneous_collagen1.04907662
112MP0002229_neurodegeneration1.04122305
113MP0003300_gastrointestinal_ulcer1.04096145
114MP0004883_abnormal_blood_vessel1.03960692
115MP0003656_abnormal_erythrocyte_physiolo1.03861126
116MP0001299_abnormal_eye_distance/1.03075184
117MP0003221_abnormal_cardiomyocyte_apopto1.02915691
118MP0009840_abnormal_foam_cell1.02732214
119MP0002735_abnormal_chemical_nociception1.02360666
120MP0001502_abnormal_circadian_rhythm1.02263321
121MP0000716_abnormal_immune_system1.02040006
122MP0001915_intracranial_hemorrhage1.01802994
123MP0000604_amyloidosis0.99613937
124MP0002090_abnormal_vision0.99090501
125MP0003091_abnormal_cell_migration0.99066559
126MP0000747_muscle_weakness0.98289235
127MP0002152_abnormal_brain_morphology0.98141140
128MP0003787_abnormal_imprinting0.97458688
129MP0010155_abnormal_intestine_physiology0.97038796
130MP0005409_darkened_coat_color0.96659214
131MP0003453_abnormal_keratinocyte_physiol0.96191217
132MP0005646_abnormal_pituitary_gland0.96158254
133MP0008961_abnormal_basal_metabolism0.95791461
134MP0006138_congestive_heart_failure0.95765358
135MP0004142_abnormal_muscle_tone0.95094791
136MP0008469_abnormal_protein_level0.93954734
137MP0003137_abnormal_impulse_conducting0.93946453
138MP0002398_abnormal_bone_marrow0.93782225
139MP0000003_abnormal_adipose_tissue0.91222626
140MP0005023_abnormal_wound_healing0.89994143
141MP0010352_gastrointestinal_tract_polyps0.88822636
142MP0004484_altered_response_of0.87683132
143MP0000465_gastrointestinal_hemorrhage0.87462441
144MP0004087_abnormal_muscle_fiber0.87296392
145MP0008775_abnormal_heart_ventricle0.87106338
146MP0005645_abnormal_hypothalamus_physiol0.85991740
147MP0001853_heart_inflammation0.84160523
148MP0002972_abnormal_cardiac_muscle0.83863536
149MP0002837_dystrophic_cardiac_calcinosis0.83548937
150MP0008874_decreased_physiological_sensi0.82149126
151MP0001485_abnormal_pinna_reflex0.82133727
152MP0000249_abnormal_blood_vessel0.81501710
153MP0005620_abnormal_muscle_contractility0.80526719
154MP0002877_abnormal_melanocyte_morpholog0.79714145
155MP0003763_abnormal_thymus_physiology0.78171030
156MP0003283_abnormal_digestive_organ0.76864697
157MP0005551_abnormal_eye_electrophysiolog0.76564458
158MP0002133_abnormal_respiratory_system0.76221920
159MP0005388_respiratory_system_phenotype0.76221920
160MP0005595_abnormal_vascular_smooth0.75795524
161MP0010630_abnormal_cardiac_muscle0.72982823
162MP0003879_abnormal_hair_cell0.72972688
163MP0003950_abnormal_plasma_membrane0.72617756
164MP0002429_abnormal_blood_cell0.71834714
165MP0001849_ear_inflammation0.71757506
166MP0000733_abnormal_muscle_development0.71581550
167MP0003183_abnormal_peptide_metabolism0.70338645
168MP0002722_abnormal_immune_system0.69283901
169MP0001984_abnormal_olfaction0.69045515
170MP0005666_abnormal_adipose_tissue0.68980273
171MP0003795_abnormal_bone_structure0.68491927
172MP0004272_abnormal_basement_membrane0.68203815
173MP0005058_abnormal_lysosome_morphology0.67870482

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.98972753
2Action tremor (HP:0002345)4.28053656
3Focal motor seizures (HP:0011153)4.18523451
4Orchitis (HP:0100796)4.07886419
5Retrobulbar optic neuritis (HP:0100654)3.93106779
6Optic neuritis (HP:0100653)3.93106779
7Supranuclear gaze palsy (HP:0000605)3.87032341
8Eczematoid dermatitis (HP:0000976)3.86821854
9Myositis (HP:0100614)3.83035848
10Focal seizures (HP:0007359)3.75823227
11Recurrent bacterial skin infections (HP:0005406)3.52432680
12Neurofibrillary tangles (HP:0002185)3.40955658
13Recurrent abscess formation (HP:0002722)3.36569668
14Ankle clonus (HP:0011448)3.31610172
15Peritonitis (HP:0002586)3.30560781
16Abnormality of macrophages (HP:0004311)3.29440204
17Intention tremor (HP:0002080)3.08299909
18Visual hallucinations (HP:0002367)3.07593162
19Dysmetria (HP:0001310)2.92795524
20Progressive cerebellar ataxia (HP:0002073)2.88986561
21Cerebral inclusion bodies (HP:0100314)2.87836900
22Recurrent gram-negative bacterial infections (HP:0005420)2.85818900
23Dysdiadochokinesis (HP:0002075)2.81131078
24Gastrointestinal infarctions (HP:0005244)2.79785687
25Postural instability (HP:0002172)2.79443580
26Amyloidosis (HP:0011034)2.78852021
27Keratoconjunctivitis sicca (HP:0001097)2.75498419
28Depression (HP:0000716)2.68626389
29Hemiplegia (HP:0002301)2.67904902
30Protrusio acetabuli (HP:0003179)2.67002247
31Bundle branch block (HP:0011710)2.63534240
32Onion bulb formation (HP:0003383)2.61804984
33Termporal pattern (HP:0011008)2.61513723
34Insidious onset (HP:0003587)2.61513723
35Spontaneous hematomas (HP:0007420)2.61350644
36Megalencephaly (HP:0001355)2.58607239
37Stomatitis (HP:0010280)2.57787506
38Urinary bladder sphincter dysfunction (HP:0002839)2.54836349
39Spastic gait (HP:0002064)2.53115573
40Epileptic encephalopathy (HP:0200134)2.50767858
41Mediastinal lymphadenopathy (HP:0100721)2.50348075
42Dilatation of the ascending aorta (HP:0005111)2.49874087
43Gaze-evoked nystagmus (HP:0000640)2.48877084
44Scanning speech (HP:0002168)2.48253082
45Urinary urgency (HP:0000012)2.48169323
46Macroorchidism (HP:0000053)2.47722455
47Atonic seizures (HP:0010819)2.44579313
48Keratoconjunctivitis (HP:0001096)2.43162847
49Abnormality of the corticospinal tract (HP:0002492)2.42837785
50Gingivitis (HP:0000230)2.40875471
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.40778900
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40778900
53Broad-based gait (HP:0002136)2.40213521
54Lower limb muscle weakness (HP:0007340)2.36883299
55Poor eye contact (HP:0000817)2.36582516
56Vascular tortuosity (HP:0004948)2.35501830
57Generalized tonic-clonic seizures (HP:0002069)2.35439768
58Lower limb amyotrophy (HP:0007210)2.35215527
59Elevated erythrocyte sedimentation rate (HP:0003565)2.33963434
60Dysmetric saccades (HP:0000641)2.32001280
61Aortic aneurysm (HP:0004942)2.31025947
62Truncal ataxia (HP:0002078)2.30894194
63Peripheral hypomyelination (HP:0007182)2.29750408
64Febrile seizures (HP:0002373)2.28719325
65Arterial thrombosis (HP:0004420)2.28452984
66Insomnia (HP:0100785)2.28286804
67Impaired vibration sensation in the lower limbs (HP:0002166)2.27379834
68Anxiety (HP:0000739)2.27167853
69Broad metatarsal (HP:0001783)2.26898231
70Papilledema (HP:0001085)2.26547702
71Obstructive sleep apnea (HP:0002870)2.26434273
72Cellulitis (HP:0100658)2.25966755
73Spondylolisthesis (HP:0003302)2.23946626
74Abnormal social behavior (HP:0012433)2.23529574
75Impaired social interactions (HP:0000735)2.23529574
76Segmental peripheral demyelination/remyelination (HP:0003481)2.22419334
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.21432407
78Abnormality of glycolipid metabolism (HP:0010969)2.21432407
79Abnormality of liposaccharide metabolism (HP:0010968)2.21432407
80Mutism (HP:0002300)2.21026646
81Episodic fever (HP:0001954)2.20824528
82Hemiparesis (HP:0001269)2.18590874
83Neuronal loss in central nervous system (HP:0002529)2.16637008
84Torticollis (HP:0000473)2.14565596
85Ventricular fibrillation (HP:0001663)2.14407740
86Difficulty running (HP:0009046)2.12993421
87Abnormality of binocular vision (HP:0011514)2.12026436
88Diplopia (HP:0000651)2.12026436
89Hemoptysis (HP:0002105)2.11536692
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10631962
91Recurrent skin infections (HP:0001581)2.10053975
92Abnormality of the endocardium (HP:0004306)2.08818899
93Absence seizures (HP:0002121)2.07848015
94Prolonged QT interval (HP:0001657)2.07775644
95Recurrent fungal infections (HP:0002841)2.06460634
96Pointed chin (HP:0000307)2.06375620
97Pulmonary infiltrates (HP:0002113)2.05237374
98Genetic anticipation (HP:0003743)2.04064562
99Chest pain (HP:0100749)2.02184177
100Rapidly progressive (HP:0003678)2.02022979
101Abnormality of the periventricular white matter (HP:0002518)2.01971339
102Dialeptic seizures (HP:0011146)2.01411253
103Cerebral aneurysm (HP:0004944)2.01115379
104Aneurysm (HP:0002617)2.00570055
105Slow saccadic eye movements (HP:0000514)2.00531109
106Vasculitis (HP:0002633)1.99607194
107Abnormality of the peritoneum (HP:0002585)1.99379689
108Aortic dissection (HP:0002647)1.98798359
109Subacute progressive viral hepatitis (HP:0006572)1.97949565
110Pheochromocytoma (HP:0002666)1.97789480
111Hematochezia (HP:0002573)1.97697402
112Premature rupture of membranes (HP:0001788)1.95600026
113Myocardial infarction (HP:0001658)1.93928516
114Mitral valve prolapse (HP:0001634)1.93863352
115Muscle fiber splitting (HP:0003555)1.93661286
116Distal upper limb amyotrophy (HP:0007149)1.93432343
117Upper limb amyotrophy (HP:0009129)1.93432343
118Abnormality of saccadic eye movements (HP:0000570)1.92433044
119Genu recurvatum (HP:0002816)1.90660190
120Atrial fibrillation (HP:0005110)1.90256223
121Abnormal eating behavior (HP:0100738)1.90238195
122Annular pancreas (HP:0001734)1.89681332
123Dysostosis multiplex (HP:0000943)1.88860571
124Resting tremor (HP:0002322)1.88852957
125Increased cerebral lipofuscin (HP:0011813)1.88556230
126Hammertoe (HP:0001765)1.88468658
127Pulmonary embolism (HP:0002204)1.87889193
128Overriding aorta (HP:0002623)1.87882662
129Shallow orbits (HP:0000586)1.87136319
130Syringomyelia (HP:0003396)1.87133207
131Spinal cord lesions (HP:0100561)1.87133207
132Mitral regurgitation (HP:0001653)1.86758197
133Progressive inability to walk (HP:0002505)1.86736306
134Lower limb asymmetry (HP:0100559)1.86519128
135Absent frontal sinuses (HP:0002688)1.86467036
136Interstitial pulmonary disease (HP:0006530)1.85518013
137Hyporeflexia of lower limbs (HP:0002600)1.85186675
138Loss of speech (HP:0002371)1.85184189
139Arterial tortuosity (HP:0005116)1.84975346
140Increased variability in muscle fiber diameter (HP:0003557)1.84027442
141Aplasia of the phalanges of the hand (HP:0009802)1.83839052
142Aplasia involving bones of the extremities (HP:0009825)1.83839052
143Aplasia involving bones of the upper limbs (HP:0009823)1.83839052
144Chronic obstructive pulmonary disease (HP:0006510)1.82781797
145Obstructive lung disease (HP:0006536)1.82781797
146Sudden death (HP:0001699)1.82171402
147Exercise-induced myalgia (HP:0003738)1.82061116
148Primary atrial arrhythmia (HP:0001692)1.81285786
149Postural tremor (HP:0002174)1.79960242
150Hyperacusis (HP:0010780)1.79662829
151Excessive salivation (HP:0003781)1.77614966
152Drooling (HP:0002307)1.77614966
153Scapular winging (HP:0003691)1.76619953
154Gingival bleeding (HP:0000225)1.76495170
155Apathy (HP:0000741)1.75645645
156Increased IgE level (HP:0003212)1.75641741
157Decreased motor nerve conduction velocity (HP:0003431)1.74604875
158Stereotypic behavior (HP:0000733)1.74496072
159Leukocytosis (HP:0001974)1.74044378
160Hypoplasia of the iris (HP:0007676)1.73896398
161Foot dorsiflexor weakness (HP:0009027)1.73758512
162Impaired smooth pursuit (HP:0007772)1.73535557
163Buphthalmos (HP:0000557)1.73144878
164Clonus (HP:0002169)1.73044163
165Meningitis (HP:0001287)1.72302377
166Abnormal EKG (HP:0003115)1.72165164
167Disinhibition (HP:0000734)1.71414945
168Asymmetric septal hypertrophy (HP:0001670)1.69937882
169Vertigo (HP:0002321)1.69480482
170Vertebral compression fractures (HP:0002953)1.68357247
171Urticaria (HP:0001025)1.68012434
172Overgrowth (HP:0001548)1.66968714
173Disproportionate tall stature (HP:0001519)1.64238034
174Abnormality of skeletal muscle fiber size (HP:0012084)1.62523152
175T lymphocytopenia (HP:0005403)1.62410435
176Recurrent cutaneous fungal infections (HP:0011370)1.61344627
177Chronic mucocutaneous candidiasis (HP:0002728)1.61344627
178Encephalitis (HP:0002383)1.60428427
179Polycythemia (HP:0001901)1.59514019
180Wormian bones (HP:0002645)1.57257844
181Metaphyseal cupping (HP:0003021)1.53028217
182Glomerulopathy (HP:0100820)1.52683844
183Subaortic stenosis (HP:0001682)1.52235411
184Abnormality of the left ventricular outflow tract (HP:0011103)1.52235411
185Mitral stenosis (HP:0001718)1.51645673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK32.78694684
2EPHA42.75269631
3IRAK32.75231736
4MAP3K92.72217159
5PRKD32.54647807
6PAK62.37024693
7MAP3K142.24163635
8MAP2K32.22466877
9TYK22.20451374
10BLK2.13242080
11KSR22.02878028
12NTRK11.99630010
13IRAK41.98464404
14CSK1.97106060
15RIPK11.92698016
16CAMKK11.90826436
17WNK11.89966029
18TRIB31.85125270
19EPHB11.84811574
20TYRO31.81243676
21DAPK21.78443401
22MAP3K41.73627130
23MARK11.67228123
24NTRK21.65716815
25CAMK1G1.57262558
26ZAP701.55767920
27MAP3K131.51694035
28STK391.51470781
29MINK11.50350517
30DMPK1.49388979
31JAK31.46615010
32PRKCH1.45263838
33SGK4941.37616281
34SGK2231.37616281
35RIPK41.36866441
36CDK51.36866434
37BMPR21.34959971
38MOS1.34852721
39MAP3K31.33209555
40JAK21.31585226
41ERN11.27437359
42IRAK21.27312450
43PHKG11.26239008
44PHKG21.26239008
45TAOK21.25531497
46TGFBR21.25343240
47MAP4K11.25041316
48STK381.24902374
49PDGFRA1.24343781
50IKBKE1.23222513
51TBK11.22530572
52FES1.21019095
53PRPF4B1.20878744
54OXSR11.20831166
55BMX1.20718200
56UHMK11.20284065
57SIK21.20271064
58CAMK1D1.18226016
59LMTK21.17800107
60RET1.14142976
61HCK1.13201085
62IRAK11.12280087
63ALK1.11266108
64PAK31.10267399
65FGFR21.07759968
66FGFR41.05002111
67SGK31.04606947
68MATK1.04591928
69PKN11.04540357
70PTK2B1.03339493
71ICK1.03325976
72PDPK11.00774238
73STK111.00473829
74GRK71.00311775
75YES10.98768713
76FGFR30.98597599
77TIE10.97983215
78MAPKAPK50.96535181
79TAOK10.95935690
80CAMKK20.95693697
81KSR10.94112404
82MAP3K60.92903851
83LATS20.92610844
84MAP3K20.90382773
85ROCK20.89936143
86NEK90.89897390
87PDK10.89521179
88TTN0.88246316
89MAP2K40.87254216
90PINK10.85737900
91MARK20.84169872
92PDGFRB0.84120112
93PRKD10.81267617
94MAP3K110.80846153
95NEK60.79567515
96PLK20.77775754
97MAPK70.76253106
98CDK120.76044279
99SGK20.75719710
100SYK0.75377146
101MAP2K70.75082590
102SGK10.73280514
103CDK150.72766859
104MAPK120.72357364
105CDK190.71276996
106EPHA30.71192033
107CDC42BPA0.70849736
108DDR20.69719304
109CDK140.69402152
110KIT0.68985427
111PTK60.68711233
112MAP3K50.67772579
113MAP3K10.67244312
114CDK180.66763130
115RAF10.66290899
116CDK60.65298900
117FYN0.64924540
118BTK0.63582106
119CAMK2A0.63367884
120PKN20.63156386
121CAMK10.62666533
122LYN0.61572416
123CAMK2D0.60942885
124CAMK2B0.60618538
125TNIK0.59685279
126JAK10.59339097
127FGR0.58216141
128CDK11A0.57902303
129PRKD20.57527516
130MAP3K70.57221230
131CAMK40.56612359
132RPS6KA30.53783435
133LCK0.53585706
134MARK30.53500400
135TNK20.52417899
136CSNK1G20.50763716
137MAPK100.50197829
138HIPK20.50082905
139WNK40.49722663
140SIK30.49239075
141IKBKB0.49005377
142ARAF0.47447648
143PRKCE0.47344026
144BRD40.47246100
145ROCK10.47146831
146MAPK130.46969074
147DYRK1B0.43181126
148PRKCG0.42140759
149GRK50.41693480
150SRC0.40483892

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.22963797
2Leishmaniasis_Homo sapiens_hsa051402.10971714
3Circadian entrainment_Homo sapiens_hsa047132.02717443
4GABAergic synapse_Homo sapiens_hsa047272.02374261
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.01400892
6Nitrogen metabolism_Homo sapiens_hsa009101.99893609
7Morphine addiction_Homo sapiens_hsa050321.96613025
8Glutamatergic synapse_Homo sapiens_hsa047241.95873753
9Nicotine addiction_Homo sapiens_hsa050331.91680002
10Synaptic vesicle cycle_Homo sapiens_hsa047211.87855622
11Malaria_Homo sapiens_hsa051441.77307326
12Long-term potentiation_Homo sapiens_hsa047201.75360678
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.75135265
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71057735
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69127380
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68207178
17Gastric acid secretion_Homo sapiens_hsa049711.66842496
18Salivary secretion_Homo sapiens_hsa049701.66040222
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61778151
20Tuberculosis_Homo sapiens_hsa051521.58992215
21Cholinergic synapse_Homo sapiens_hsa047251.58589202
22TNF signaling pathway_Homo sapiens_hsa046681.57876265
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52449472
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.51590469
25Renin secretion_Homo sapiens_hsa049241.50205848
26Dopaminergic synapse_Homo sapiens_hsa047281.50100708
27Acute myeloid leukemia_Homo sapiens_hsa052211.47556613
28Staphylococcus aureus infection_Homo sapiens_hsa051501.46046923
29Amphetamine addiction_Homo sapiens_hsa050311.43353753
30Legionellosis_Homo sapiens_hsa051341.40415356
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40225626
32Oxytocin signaling pathway_Homo sapiens_hsa049211.39637425
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.37041139
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35770212
35Dilated cardiomyopathy_Homo sapiens_hsa054141.35540134
36Long-term depression_Homo sapiens_hsa047301.35217351
37Toxoplasmosis_Homo sapiens_hsa051451.32047665
38Insulin secretion_Homo sapiens_hsa049111.32011334
39African trypanosomiasis_Homo sapiens_hsa051431.31560063
40Dorso-ventral axis formation_Homo sapiens_hsa043201.28612252
41Measles_Homo sapiens_hsa051621.28487632
42Pertussis_Homo sapiens_hsa051331.27773785
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26218138
44Other glycan degradation_Homo sapiens_hsa005111.26165116
45Influenza A_Homo sapiens_hsa051641.26070568
46Cocaine addiction_Homo sapiens_hsa050301.25279009
47cAMP signaling pathway_Homo sapiens_hsa040241.25008473
48Type II diabetes mellitus_Homo sapiens_hsa049301.22958060
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21861945
50Glioma_Homo sapiens_hsa052141.21155943
51GnRH signaling pathway_Homo sapiens_hsa049121.20319322
52Gap junction_Homo sapiens_hsa045401.19522495
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.19118628
54Hepatitis B_Homo sapiens_hsa051611.18044533
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17616169
56Estrogen signaling pathway_Homo sapiens_hsa049151.14626958
57Axon guidance_Homo sapiens_hsa043601.14599525
58Calcium signaling pathway_Homo sapiens_hsa040201.13761110
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13517097
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.13455921
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10181091
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09306865
63Notch signaling pathway_Homo sapiens_hsa043301.05362592
64Taste transduction_Homo sapiens_hsa047421.04476464
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.02274708
66Serotonergic synapse_Homo sapiens_hsa047261.02200488
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02037279
68ErbB signaling pathway_Homo sapiens_hsa040121.01247823
69Hepatitis C_Homo sapiens_hsa051601.00669124
70Renal cell carcinoma_Homo sapiens_hsa052110.99278867
71T cell receptor signaling pathway_Homo sapiens_hsa046600.99181931
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.93529263
73Shigellosis_Homo sapiens_hsa051310.92752064
74Phagosome_Homo sapiens_hsa041450.91620565
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90431980
76Endocytosis_Homo sapiens_hsa041440.88839711
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.88748454
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88688464
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.87940943
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87480401
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87024461
82Chemokine signaling pathway_Homo sapiens_hsa040620.85932975
83Melanogenesis_Homo sapiens_hsa049160.85239897
84Rheumatoid arthritis_Homo sapiens_hsa053230.85010218
85MAPK signaling pathway_Homo sapiens_hsa040100.83144876
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.82758966
87FoxO signaling pathway_Homo sapiens_hsa040680.82446064
88Graft-versus-host disease_Homo sapiens_hsa053320.82279636
89HIF-1 signaling pathway_Homo sapiens_hsa040660.81797112
90Bladder cancer_Homo sapiens_hsa052190.80466270
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79781417
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79372919
93Choline metabolism in cancer_Homo sapiens_hsa052310.79314346
94Rap1 signaling pathway_Homo sapiens_hsa040150.78222947
95VEGF signaling pathway_Homo sapiens_hsa043700.78033306
96Focal adhesion_Homo sapiens_hsa045100.75786544
97Herpes simplex infection_Homo sapiens_hsa051680.75577067
98Colorectal cancer_Homo sapiens_hsa052100.75414776
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75363683
100Apoptosis_Homo sapiens_hsa042100.74348057
101Platelet activation_Homo sapiens_hsa046110.74230948
102Allograft rejection_Homo sapiens_hsa053300.73623198
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73228614
104Viral myocarditis_Homo sapiens_hsa054160.71859652
105Pancreatic secretion_Homo sapiens_hsa049720.69870823
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69234955
107Prostate cancer_Homo sapiens_hsa052150.68796055
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68356960
109Non-small cell lung cancer_Homo sapiens_hsa052230.68354367
110Ras signaling pathway_Homo sapiens_hsa040140.68346392
111Hematopoietic cell lineage_Homo sapiens_hsa046400.66568757
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66094816
113Ovarian steroidogenesis_Homo sapiens_hsa049130.65675661
114Inositol phosphate metabolism_Homo sapiens_hsa005620.65238778
115Amoebiasis_Homo sapiens_hsa051460.64990273
116mTOR signaling pathway_Homo sapiens_hsa041500.64618464
117Adherens junction_Homo sapiens_hsa045200.64266728
118Thyroid hormone synthesis_Homo sapiens_hsa049180.64136905
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63908987
120MicroRNAs in cancer_Homo sapiens_hsa052060.63725581
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63676325
122Proteoglycans in cancer_Homo sapiens_hsa052050.63585442
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63210507
124Small cell lung cancer_Homo sapiens_hsa052220.63029505
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62965748
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62438449
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61794321
128Endometrial cancer_Homo sapiens_hsa052130.59793054
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58700760
130Chronic myeloid leukemia_Homo sapiens_hsa052200.58324360
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58262564
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58147800
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.57468360
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56902093
135Cardiac muscle contraction_Homo sapiens_hsa042600.55250620
136Fatty acid biosynthesis_Homo sapiens_hsa000610.55236778
137Osteoclast differentiation_Homo sapiens_hsa043800.54901670
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.54387789
139Tight junction_Homo sapiens_hsa045300.52447200
140Prion diseases_Homo sapiens_hsa050200.49822958
141ECM-receptor interaction_Homo sapiens_hsa045120.49615191
142Salmonella infection_Homo sapiens_hsa051320.48216064
143B cell receptor signaling pathway_Homo sapiens_hsa046620.47783180
144Prolactin signaling pathway_Homo sapiens_hsa049170.46335180
145Lysosome_Homo sapiens_hsa041420.45768348
146Insulin signaling pathway_Homo sapiens_hsa049100.44206088
147Pancreatic cancer_Homo sapiens_hsa052120.43826171
148Bile secretion_Homo sapiens_hsa049760.41845196

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