DENND4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.71097813
2regulation of gamma-delta T cell differentiation (GO:0045586)5.25291027
3negative regulation of cell killing (GO:0031342)5.14139253
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.14139253
5regulation of gamma-delta T cell activation (GO:0046643)5.03432177
6antigen processing and presentation of endogenous antigen (GO:0019883)4.97379913
7positive thymic T cell selection (GO:0045059)4.77598111
8regulation of B cell receptor signaling pathway (GO:0050855)4.74223541
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70185976
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70185976
11B cell receptor signaling pathway (GO:0050853)4.66682962
12positive regulation of B cell differentiation (GO:0045579)4.37993435
13detection of other organism (GO:0098543)4.24185189
14detection of bacterium (GO:0016045)4.21438124
15regulation of B cell differentiation (GO:0045577)4.06791966
16regulation of interleukin-12 biosynthetic process (GO:0045075)4.01527367
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98563099
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.98563099
19modulation by symbiont of host immune response (GO:0052553)3.98563099
20positive regulation by symbiont of host defense response (GO:0052509)3.98563099
21modulation by symbiont of host defense response (GO:0052031)3.98563099
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98563099
23negative thymic T cell selection (GO:0045060)3.87935018
24germinal center formation (GO:0002467)3.84620085
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.81902911
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80609509
27mannose metabolic process (GO:0006013)3.78829436
28positive T cell selection (GO:0043368)3.77821699
29regulation of interferon-beta biosynthetic process (GO:0045357)3.76513736
30negative T cell selection (GO:0043383)3.74025478
31thymic T cell selection (GO:0045061)3.73344952
32mature B cell differentiation (GO:0002335)3.65597695
33response to interleukin-15 (GO:0070672)3.60584977
34T cell selection (GO:0045058)3.52659488
35macrophage activation involved in immune response (GO:0002281)3.48726797
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.46896729
37cellular response to zinc ion (GO:0071294)3.43796620
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41141444
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40079517
40detection of external biotic stimulus (GO:0098581)3.38606589
41NIK/NF-kappaB signaling (GO:0038061)3.37765651
42negative regulation of T cell mediated immunity (GO:0002710)3.34199542
43immunoglobulin mediated immune response (GO:0016064)3.33173875
44negative regulation of leukocyte mediated immunity (GO:0002704)3.30879101
45regulation of mast cell degranulation (GO:0043304)3.30504130
46T cell migration (GO:0072678)3.27987067
47tolerance induction (GO:0002507)3.27640591
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24602839
49regulation of leukocyte degranulation (GO:0043300)3.23526136
50neutrophil activation involved in immune response (GO:0002283)3.21149380
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20677662
52defense response to protozoan (GO:0042832)3.17648656
53cellular extravasation (GO:0045123)3.17175928
54leukocyte aggregation (GO:0070486)3.16903786
55positive regulation of antigen processing and presentation (GO:0002579)3.14612387
56response to muramyl dipeptide (GO:0032495)3.12049492
57interferon-gamma-mediated signaling pathway (GO:0060333)3.10677384
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.05447952
59myeloid dendritic cell activation (GO:0001773)3.03635707
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.03630639
61regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00687433
62detection of biotic stimulus (GO:0009595)3.00266766
63cellular response to interleukin-15 (GO:0071350)2.99450873
64antigen receptor-mediated signaling pathway (GO:0050851)2.99136547
65myeloid dendritic cell differentiation (GO:0043011)2.97009125
66neutrophil activation (GO:0042119)2.96142482
67positive regulation of Rap GTPase activity (GO:0032854)2.95052373
68positive regulation of interferon-alpha production (GO:0032727)2.94017009
69myeloid cell activation involved in immune response (GO:0002275)2.93839883
70regulation of mast cell activation involved in immune response (GO:0033006)2.92571225
71regulation of T-helper 2 cell differentiation (GO:0045628)2.90494282
72B cell homeostasis (GO:0001782)2.89947944
73respiratory burst (GO:0045730)2.89370703
74regulation of interferon-alpha production (GO:0032647)2.88878883
75natural killer cell differentiation (GO:0001779)2.86327941
76positive regulation of interleukin-2 production (GO:0032743)2.86009143
77negative regulation of interleukin-12 production (GO:0032695)2.85726955
78detection of molecule of bacterial origin (GO:0032490)2.85106158
79response to protozoan (GO:0001562)2.84374431
80positive regulation of histone deacetylation (GO:0031065)2.82988219
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82932431
82T cell homeostasis (GO:0043029)2.82660900
83granulocyte activation (GO:0036230)2.82002480
84lymphocyte homeostasis (GO:0002260)2.79870686
85negative regulation of granulocyte differentiation (GO:0030853)2.79743463
86regulation of regulated secretory pathway (GO:1903305)2.79158282
87B cell proliferation (GO:0042100)2.78905099
88Peyers patch development (GO:0048541)2.74007399
89mucosal-associated lymphoid tissue development (GO:0048537)2.74007399
90regulation of alpha-beta T cell proliferation (GO:0046640)2.73905890
91regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72690491
92mast cell activation (GO:0045576)2.70271754
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.69002293
94signal complex assembly (GO:0007172)2.68921549
95regulation of ARF protein signal transduction (GO:0032012)2.68873484
96response to laminar fluid shear stress (GO:0034616)2.67599468
97negative regulation of innate immune response (GO:0045824)2.67182980
98histone H3-K36 demethylation (GO:0070544)2.65923652
99macrophage activation (GO:0042116)2.65642318
100regulation of natural killer cell mediated immunity (GO:0002715)2.64509222
101regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64509222
102activated T cell proliferation (GO:0050798)2.64456422
103regulation of tolerance induction (GO:0002643)2.63971866
104positive regulation of cellular amide metabolic process (GO:0034250)2.62347101
105positive regulation of mast cell activation (GO:0033005)2.61418448
106negative regulation of erythrocyte differentiation (GO:0045647)2.61213575
107immune response-activating cell surface receptor signaling pathway (GO:0002429)2.61060358
108mature B cell differentiation involved in immune response (GO:0002313)2.60332307
109leukocyte cell-cell adhesion (GO:0007159)2.59999564
110response to type I interferon (GO:0034340)2.58228749
111response to peptidoglycan (GO:0032494)2.57047675
112regulation of interleukin-2 biosynthetic process (GO:0045076)2.56565437
113regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56547413
114negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56170355
115response to host immune response (GO:0052572)2.55241367
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55241367
117activation of JUN kinase activity (GO:0007257)2.54231875
118negative regulation of B cell proliferation (GO:0030889)2.53911757
119antigen processing and presentation via MHC class Ib (GO:0002475)2.53482430
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53181387
121negative regulation of phagocytosis (GO:0050765)2.53099712
122negative regulation of interleukin-6 production (GO:0032715)2.52823665
123cellular response to type I interferon (GO:0071357)2.52009428
124type I interferon signaling pathway (GO:0060337)2.52009428
125regulation of regulatory T cell differentiation (GO:0045589)2.51070245
126T cell proliferation (GO:0042098)2.50358876
127regulation of T cell tolerance induction (GO:0002664)2.50294493
128T cell receptor signaling pathway (GO:0050852)2.49698712
129T cell costimulation (GO:0031295)2.48321033
130response to host (GO:0075136)2.47996360
131response to host defenses (GO:0052200)2.47996360
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47996360
133regulation of B cell proliferation (GO:0030888)2.47662781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.79027980
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.66144501
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.43716064
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85465280
5* IRF8_21731497_ChIP-ChIP_J774_Mouse3.61037020
6MYC_22102868_ChIP-Seq_BL_Human3.37905635
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36083314
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.17487521
9VDR_21846776_ChIP-Seq_THP-1_Human3.11277341
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08896755
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90109329
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.89390374
13SCL_19346495_ChIP-Seq_HPC-7_Human2.85419199
14* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84148826
15RUNX_20019798_ChIP-Seq_JUKART_Human2.79018689
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71137475
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.60378969
18* MAF_26560356_Chip-Seq_TH1_Human2.56271583
19* TCF7_22412390_ChIP-Seq_EML_Mouse2.55220781
20* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49841868
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.46445662
22SPI1_23127762_ChIP-Seq_K562_Human2.45277024
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41235010
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39779412
25* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37484582
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37408312
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36106117
28* KDM2B_26808549_Chip-Seq_DND41_Human2.33953870
29VDR_24763502_ChIP-Seq_THP-1_Human2.32515580
30MYB_26560356_Chip-Seq_TH2_Human2.24531721
31* UTX_26944678_Chip-Seq_JUKART_Human2.17833371
32* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13619662
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.07097282
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06786210
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06462812
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05055631
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02217659
38* MYB_26560356_Chip-Seq_TH1_Human1.97683896
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.95162184
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89817054
41* SPI1_23547873_ChIP-Seq_NB4_Human1.80509761
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75824950
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.64680748
44NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.61340032
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.60600862
46RACK7_27058665_Chip-Seq_MCF-7_Human1.60448610
47* MAF_26560356_Chip-Seq_TH2_Human1.57544835
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57124634
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54194892
50GATA3_27048872_Chip-Seq_THYMUS_Human1.50970230
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49603799
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49063885
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45830726
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44276806
55GATA1_22025678_ChIP-Seq_K562_Human1.39162302
56PU_27001747_Chip-Seq_BMDM_Mouse1.38600772
57* KDM2B_26808549_Chip-Seq_JURKAT_Human1.38507799
58* LXR_22292898_ChIP-Seq_THP-1_Human1.36038714
59GATA1_19941826_ChIP-Seq_K562_Human1.34166477
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32864475
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32244370
62* SA1_27219007_Chip-Seq_ERYTHROID_Human1.31865876
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31395605
64* P68_20966046_ChIP-Seq_HELA_Human1.29129045
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24272805
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24042701
67VDR_24787735_ChIP-Seq_THP-1_Human1.22592037
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22405864
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21686308
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20096650
71SMC4_20622854_ChIP-Seq_HELA_Human1.18913180
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16212652
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15416197
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13017672
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12426514
76DROSHA_22980978_ChIP-Seq_HELA_Human1.09970140
77GATA2_19941826_ChIP-Seq_K562_Human1.09307569
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07462622
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07291457
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07138149
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06955101
82CIITA_25753668_ChIP-Seq_RAJI_Human1.06564597
83KDM2B_26808549_Chip-Seq_K562_Human1.06245424
84* CREB1_26743006_Chip-Seq_LNCaP_Human1.03456515
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03398971
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02706828
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.01498477
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.01017826
89NCOR1_26117541_ChIP-Seq_K562_Human0.99789798
90* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99500456
91GATA3_26560356_Chip-Seq_TH2_Human0.98314765
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97389903
93ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97218122
94* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97156466
95SPI1_20517297_ChIP-Seq_HL60_Human0.97049789
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96841734
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95715670
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.95101075
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.95101075
100* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94958455
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92398276
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92394444
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91780089
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89289898
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89278140
106* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88510346
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88505641
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87209917
109BCOR_27268052_Chip-Seq_Bcells_Human0.87042048
110BCL6_27268052_Chip-Seq_Bcells_Human0.86670696
111* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86538201
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85397130
113RARB_27405468_Chip-Seq_BRAIN_Mouse0.85011888
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83082613
115* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83066848
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.81480090
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79647806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.88272234
2MP0004510_myositis3.48317517
3MP0003303_peritoneal_inflammation3.42340628
4MP0001790_abnormal_immune_system3.25557440
5MP0005387_immune_system_phenotype3.25557440
6MP0001800_abnormal_humoral_immune3.18890808
7MP0000685_abnormal_immune_system2.97570855
8MP0005671_abnormal_response_to2.72726952
9MP0005000_abnormal_immune_tolerance2.70858759
10MP0002452_abnormal_antigen_presenting2.64442418
11MP0003436_decreased_susceptibility_to2.58420325
12MP0005451_abnormal_body_composition2.54929860
13MP0002723_abnormal_immune_serum2.48799743
14MP0000569_abnormal_digit_pigmentation2.39022384
15MP0002420_abnormal_adaptive_immunity2.36150011
16MP0003646_muscle_fatigue2.35318013
17MP0001819_abnormal_immune_cell2.32358336
18MP0002419_abnormal_innate_immunity2.25366979
19MP0005025_abnormal_response_to2.18961318
20MP0002398_abnormal_bone_marrow2.11700914
21MP0008260_abnormal_autophagy2.08638396
22MP0003763_abnormal_thymus_physiology2.07804206
23MP0002148_abnormal_hypersensitivity_rea2.03361995
24MP0003300_gastrointestinal_ulcer1.99190092
25MP0009785_altered_susceptibility_to1.96460716
26MP0002396_abnormal_hematopoietic_system1.96019671
27MP0000716_abnormal_immune_system1.95482731
28MP0009278_abnormal_bone_marrow1.95014836
29MP0002166_altered_tumor_susceptibility1.85737791
30MP0000689_abnormal_spleen_morphology1.81667330
31MP0005464_abnormal_platelet_physiology1.81130393
32MP0002405_respiratory_system_inflammati1.78891267
33MP0003172_abnormal_lysosome_physiology1.78257803
34MP0001853_heart_inflammation1.73295783
35MP0001873_stomach_inflammation1.72146838
36MP0005058_abnormal_lysosome_morphology1.70318325
37MP0002722_abnormal_immune_system1.66530382
38MP0006082_CNS_inflammation1.63607985
39MP0004808_abnormal_hematopoietic_stem1.60694012
40MP0000751_myopathy1.60394265
41MP0002429_abnormal_blood_cell1.57985712
42MP0003705_abnormal_hypodermis_morpholog1.57803688
43MP0004947_skin_inflammation1.57740205
44MP0004036_abnormal_muscle_relaxation1.55234484
45MP0004381_abnormal_hair_follicle1.51556482
46MP0004130_abnormal_muscle_cell1.45645364
47MP0000703_abnormal_thymus_morphology1.43963509
48MP0000858_altered_metastatic_potential1.43919144
49MP0005174_abnormal_tail_pigmentation1.43811607
50MP0002837_dystrophic_cardiac_calcinosis1.42414344
51MP0001845_abnormal_inflammatory_respons1.40311738
52MP0002006_tumorigenesis1.38118592
53MP0010155_abnormal_intestine_physiology1.37920324
54MP0004084_abnormal_cardiac_muscle1.36558391
55MP0000749_muscle_degeneration1.31443466
56MP0003866_abnormal_defecation1.30094515
57MP0005397_hematopoietic_system_phenotyp1.26841103
58MP0001545_abnormal_hematopoietic_system1.26841103
59MP0005310_abnormal_salivary_gland1.24924832
60MP0004087_abnormal_muscle_fiber1.21638168
61MP0002106_abnormal_muscle_physiology1.20419352
62MP0004185_abnormal_adipocyte_glucose1.15840567
63MP0003828_pulmonary_edema1.15634162
64MP0008961_abnormal_basal_metabolism1.14118989
65MP0009333_abnormal_splenocyte_physiolog1.12684702
66MP0003075_altered_response_to1.11351803
67MP0000343_altered_response_to1.11329083
68MP0001533_abnormal_skeleton_physiology1.10682705
69MP0003183_abnormal_peptide_metabolism1.10543787
70MP0004145_abnormal_muscle_electrophysio1.07977580
71MP0000747_muscle_weakness1.07856210
72MP0009840_abnormal_foam_cell1.07109694
73MP0002132_abnormal_respiratory_system1.05532837
74MP0010630_abnormal_cardiac_muscle1.03393273
75MP0002009_preneoplasia1.02839696
76MP0001849_ear_inflammation1.02181911
77MP0000604_amyloidosis1.02149407
78MP0000465_gastrointestinal_hemorrhage1.01792743
79MP0008469_abnormal_protein_level1.00772039
80MP0005076_abnormal_cell_differentiation0.98205133
81MP0002933_joint_inflammation0.97655242
82MP0005666_abnormal_adipose_tissue0.96623178
83MP0004859_abnormal_synaptic_plasticity0.92619935
84MP0003453_abnormal_keratinocyte_physiol0.91643853
85MP0000750_abnormal_muscle_regeneration0.89333253
86MP0000759_abnormal_skeletal_muscle0.89057176
87MP0003448_altered_tumor_morphology0.88361223
88MP0003690_abnormal_glial_cell0.87976850
89MP0000015_abnormal_ear_pigmentation0.87357784
90MP0001851_eye_inflammation0.87270875
91MP0005166_decreased_susceptibility_to0.83518227
92MP0003656_abnormal_erythrocyte_physiolo0.83410652
93MP0003724_increased_susceptibility_to0.80941989
94MP0002332_abnormal_exercise_endurance0.80431738
95MP0005330_cardiomyopathy0.80320251
96MP0005369_muscle_phenotype0.79614865
97MP0001348_abnormal_lacrimal_gland0.79547259
98MP0008569_lethality_at_weaning0.78840985
99MP0002877_abnormal_melanocyte_morpholog0.78586472
100MP0003329_amyloid_beta_deposits0.77860777
101MP0003045_fibrosis0.77439722
102MP0008874_decreased_physiological_sensi0.76130432
103MP0000733_abnormal_muscle_development0.75167689
104MP0000490_abnormal_crypts_of0.74650505
105MP0004484_altered_response_of0.74350546
106MP0002998_abnormal_bone_remodeling0.73650346
107MP0003091_abnormal_cell_migration0.73600804
108MP0004215_abnormal_myocardial_fiber0.73389057
109MP0009764_decreased_sensitivity_to0.71486848
110MP0001544_abnormal_cardiovascular_syste0.70837302
111MP0005385_cardiovascular_system_phenoty0.70837302
112MP0002269_muscular_atrophy0.70510375
113MP0010352_gastrointestinal_tract_polyps0.70020353
114MP0005390_skeleton_phenotype0.68918335
115MP0004883_abnormal_blood_vessel0.68902826
116MP0002972_abnormal_cardiac_muscle0.68420553
117MP0010307_abnormal_tumor_latency0.67281824
118MP0003191_abnormal_cellular_cholesterol0.67005643
119MP0005409_darkened_coat_color0.66390165
120MP0005375_adipose_tissue_phenotype0.65863069
121MP0001663_abnormal_digestive_system0.65125921
122MP0002138_abnormal_hepatobiliary_system0.64344608
123MP0004858_abnormal_nervous_system0.64217164
124MP0005621_abnormal_cell_physiology0.64143826
125MP0003566_abnormal_cell_adhesion0.63322643
126MP0000920_abnormal_myelination0.62836906
127MP0003795_abnormal_bone_structure0.62436438
128MP0000249_abnormal_blood_vessel0.58395914
129MP0002019_abnormal_tumor_incidence0.57713070
130MP0009763_increased_sensitivity_to0.57240009

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.76352787
2Recurrent bacterial skin infections (HP:0005406)4.26291720
3Eczematoid dermatitis (HP:0000976)4.13570328
4Recurrent viral infections (HP:0004429)4.01316040
5Agammaglobulinemia (HP:0004432)3.97453957
6Colitis (HP:0002583)3.89314449
7Recurrent fungal infections (HP:0002841)3.81490693
8Inflammation of the large intestine (HP:0002037)3.80510183
9Cellulitis (HP:0100658)3.79419327
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.69983157
11Gastrointestinal inflammation (HP:0004386)3.64320001
12Gastrointestinal stroma tumor (HP:0100723)3.62134883
13Panhypogammaglobulinemia (HP:0003139)3.52284498
14Elevated erythrocyte sedimentation rate (HP:0003565)3.51631576
15Recurrent bronchitis (HP:0002837)3.45072731
16Mediastinal lymphadenopathy (HP:0100721)3.42075952
17Chronic otitis media (HP:0000389)3.36897820
18Exercise-induced myalgia (HP:0003738)3.32627592
19Chronic mucocutaneous candidiasis (HP:0002728)3.30950455
20Recurrent cutaneous fungal infections (HP:0011370)3.30950455
21Meningitis (HP:0001287)3.21343875
22IgM deficiency (HP:0002850)3.17638779
23Recurrent skin infections (HP:0001581)3.15461158
24Myositis (HP:0100614)3.15040306
25Spontaneous hematomas (HP:0007420)3.08006038
26Vasculitis (HP:0002633)3.05229587
27Exercise-induced muscle cramps (HP:0003710)3.04195599
28Gastrointestinal infarctions (HP:0005244)2.99115381
29Nasal polyposis (HP:0100582)2.97040923
30Stomatitis (HP:0010280)2.96449051
31Papilloma (HP:0012740)2.95474403
32Verrucae (HP:0200043)2.95474403
33T lymphocytopenia (HP:0005403)2.86402968
34Abnormality of the fingertips (HP:0001211)2.78059963
35Asymmetric septal hypertrophy (HP:0001670)2.75636826
36Frequent falls (HP:0002359)2.74363156
37Abnormality of T cell number (HP:0011839)2.74305430
38Encephalitis (HP:0002383)2.70343354
39Obstructive sleep apnea (HP:0002870)2.70316175
40Abnormality of the nasal mucosa (HP:0000433)2.70114445
41Muscle hypertrophy of the lower extremities (HP:0008968)2.69587198
42Chest pain (HP:0100749)2.68214817
43Hematochezia (HP:0002573)2.68171833
44Calf muscle hypertrophy (HP:0008981)2.66715432
45Autoimmune thrombocytopenia (HP:0001973)2.66229489
46Chronic obstructive pulmonary disease (HP:0006510)2.65534920
47Obstructive lung disease (HP:0006536)2.65534920
48Emphysema (HP:0002097)2.64233250
49Recurrent gram-negative bacterial infections (HP:0005420)2.61227276
50Restrictive lung disease (HP:0002091)2.57831395
51Lymphopenia (HP:0001888)2.56574964
52Increased cerebral lipofuscin (HP:0011813)2.54044661
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.50375221
54Recurrent sinusitis (HP:0011108)2.49375433
55Difficulty running (HP:0009046)2.45690254
56Pustule (HP:0200039)2.45447988
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.45137051
58Abnormality of the left ventricular outflow tract (HP:0011103)2.44328723
59Subaortic stenosis (HP:0001682)2.44328723
60Abnormality of macrophages (HP:0004311)2.44050355
61Abnormality of T cells (HP:0002843)2.43515258
62Thyroiditis (HP:0100646)2.43305327
63Dysostosis multiplex (HP:0000943)2.38350087
64Gingivitis (HP:0000230)2.34267101
65Orchitis (HP:0100796)2.28308650
66Slow saccadic eye movements (HP:0000514)2.27348022
67Sudden death (HP:0001699)2.25323867
68Urticaria (HP:0001025)2.23984927
69Osteomyelitis (HP:0002754)2.22468608
70Pulmonary infiltrates (HP:0002113)2.22319400
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.21961104
72Viral hepatitis (HP:0006562)2.20275610
73Granulocytopenia (HP:0001913)2.18829083
74Hyporeflexia of lower limbs (HP:0002600)2.17997929
75Prolonged bleeding time (HP:0003010)2.17968421
76Keratoconjunctivitis sicca (HP:0001097)2.14722311
77Neuronal loss in central nervous system (HP:0002529)2.11518542
78Arterial thrombosis (HP:0004420)2.10270344
79Hemoptysis (HP:0002105)2.09213836
80Fatigue (HP:0012378)2.09086734
81B lymphocytopenia (HP:0010976)2.09086662
82Abnormality of B cell number (HP:0010975)2.09086662
83Leukocytosis (HP:0001974)2.07711643
84Periodontitis (HP:0000704)2.06116096
85Polygenic inheritance (HP:0010982)2.04058075
86Chronic sinusitis (HP:0011109)2.02770552
87Loss of speech (HP:0002371)2.02584256
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02116986
89Retrobulbar optic neuritis (HP:0100654)2.02116375
90Optic neuritis (HP:0100653)2.02116375
91Abnormality of T cell physiology (HP:0011840)2.02026550
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.01749173
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.01648469
94Abnormality of glycolipid metabolism (HP:0010969)2.01648469
95Abnormality of liposaccharide metabolism (HP:0010968)2.01648469
96Broad face (HP:0000283)2.00015465
97Systemic lupus erythematosus (HP:0002725)1.99514382
98Cerebral aneurysm (HP:0004944)1.99158251
99Distal lower limb amyotrophy (HP:0008944)1.97053037
100Increased IgE level (HP:0003212)1.96914410
101Muscle fiber inclusion bodies (HP:0100299)1.96694022
102EMG: myopathic abnormalities (HP:0003458)1.96087440
103Hypochromic anemia (HP:0001931)1.94806726
104Gingival bleeding (HP:0000225)1.94303526
105Sepsis (HP:0100806)1.93759100
106Facial diplegia (HP:0001349)1.93277533
107Increased serum ferritin (HP:0003281)1.92793708
108Myoglobinuria (HP:0002913)1.92208106
109IgA deficiency (HP:0002720)1.91929004
110Increased density of long bones (HP:0006392)1.91809285
111Epistaxis (HP:0000421)1.90802870
112Supranuclear gaze palsy (HP:0000605)1.90701257
113Interstitial pulmonary disease (HP:0006530)1.89756849
114Purpura (HP:0000979)1.89553262
115Dysmetric saccades (HP:0000641)1.89363593
116Metaphyseal cupping (HP:0003021)1.88842145
117Chronic diarrhea (HP:0002028)1.88658454
118Keratoconjunctivitis (HP:0001096)1.87622343
119Hemorrhage of the eye (HP:0011885)1.87419357
120Disinhibition (HP:0000734)1.87336783
121Eosinophilia (HP:0001880)1.85704102
122Axonal loss (HP:0003447)1.85527969
123Bundle branch block (HP:0011710)1.84957720
124Pulmonary embolism (HP:0002204)1.84795279
125Petechiae (HP:0000967)1.84637879
126Thrombocytosis (HP:0001894)1.84545439
127Amyloidosis (HP:0011034)1.84156723
128Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.83117260
129Segmental peripheral demyelination/remyelination (HP:0003481)1.81614014
130Muscle fiber splitting (HP:0003555)1.81193948
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80406156
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80406156
133Abnormality of polysaccharide metabolism (HP:0011012)1.80406156
134Mucopolysacchariduria (HP:0008155)1.80039193
135Urinary glycosaminoglycan excretion (HP:0003541)1.80039193
136Hypertensive crisis (HP:0100735)1.79909352
137Papilledema (HP:0001085)1.77575729
138Increased connective tissue (HP:0009025)1.77150771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.06666285
2PRPF4B3.86845783
3TTN2.78356740
4RIPK42.77775416
5MAP3K132.65958610
6SIK22.60667649
7TYK22.48887975
8BLK2.48167544
9MAP3K102.46970151
10MAP3K142.41040689
11ERN12.18174287
12JAK32.11076151
13TRIB31.99695604
14SMG11.93135635
15JAK11.89575732
16TBK11.88886300
17CSF1R1.85089239
18KIT1.83930773
19SYK1.82453597
20FES1.69012743
21GRK61.68692823
22HCK1.58828589
23PKN21.56567407
24EPHB11.55916232
25BTK1.55519051
26IKBKE1.54787128
27CAMK1G1.54253719
28TXK1.52165787
29ZAP701.51722149
30ICK1.51288430
31EEF2K1.48623699
32TGFBR21.44851975
33IRAK31.40827119
34STK101.38315043
35IRAK41.37675636
36IKBKB1.36282953
37MAP3K71.33343381
38CAMK1D1.31931936
39MAP3K31.28464611
40CSK1.23727326
41MAP2K31.22364782
42LCK1.20215501
43ITK1.19407258
44CDK121.18171771
45MAP3K91.13051034
46DMPK1.08496122
47TAOK21.05308405
48OBSCN1.02562256
49LRRK21.01702055
50PTK61.01695318
51PHKG21.00464864
52PHKG11.00464864
53PRKCH0.98157733
54MAPK120.97788361
55ALK0.95333087
56JAK20.94776919
57CLK10.94774927
58PRKD20.93298124
59FGFR30.93115065
60PDK10.90172642
61TEC0.88065877
62LYN0.86751595
63MARK30.83179910
64RIPK10.81972007
65IRAK20.80784753
66CHUK0.80620426
67FGFR40.79431258
68CDK40.77251361
69TAOK10.76922327
70PRKCQ0.74940349
71MAPK110.69404757
72TNK20.67030804
73RET0.63268742
74HIPK20.61429178
75TYRO30.59603138
76IRAK10.57006591
77SGK30.56139479
78FGR0.55934615
79PIM10.55752135
80CAMKK10.55644335
81PRKD10.54521710
82GRK70.54094683
83PDPK10.53686933
84MTOR0.53259969
85MARK20.52770428
86RPS6KA20.52581485
87MAP3K60.51316803
88KSR20.51089404
89EPHA30.50183234
90CAMK40.50176984
91TAOK30.50135539
92YES10.49471635
93MAPK70.49407832
94BMX0.48174069
95MAP2K20.47892592
96STK110.46658612
97FYN0.46107220
98PKN10.45790667
99EGFR0.45768954
100DYRK1B0.44720482
101CDK60.44106538
102MAP3K80.42914827
103BRD40.42086609
104SIK30.41818790
105RPS6KA60.40276045
106STK40.39956742
107BMPR20.39891654
108MAPK40.39701425
109PRKAA20.38146285
110MAP2K60.37665570
111TRPM70.37602421
112CAMK10.37032317
113WNK10.36785494
114SIK10.35647798
115NME20.34928413
116PIK3CG0.34055590
117MAPKAPK20.33662857
118ABL10.33392058
119DAPK20.32913861
120MAP3K10.30415162
121MAP3K110.30184786
122CDC42BPA0.29880337
123CAMKK20.29566706
124RPS6KC10.29367050
125RPS6KL10.29367050
126MATK0.28078546
127PAK60.27945909

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.37583213
2Primary immunodeficiency_Homo sapiens_hsa053402.90901726
3Osteoclast differentiation_Homo sapiens_hsa043802.49698902
4Leishmaniasis_Homo sapiens_hsa051402.34280777
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.12103269
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.02434381
7T cell receptor signaling pathway_Homo sapiens_hsa046601.94426421
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89263277
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87960325
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.76938615
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70140015
12Autoimmune thyroid disease_Homo sapiens_hsa053201.68547738
13Measles_Homo sapiens_hsa051621.68074017
14Hematopoietic cell lineage_Homo sapiens_hsa046401.64769269
15Chemokine signaling pathway_Homo sapiens_hsa040621.63904545
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.59928807
17Tuberculosis_Homo sapiens_hsa051521.59652863
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51660709
19Viral myocarditis_Homo sapiens_hsa054161.51485136
20Toxoplasmosis_Homo sapiens_hsa051451.45846789
21Acute myeloid leukemia_Homo sapiens_hsa052211.37979877
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34997622
23Staphylococcus aureus infection_Homo sapiens_hsa051501.34779426
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33845998
25Chronic myeloid leukemia_Homo sapiens_hsa052201.29455503
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28484557
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.27685199
28Pertussis_Homo sapiens_hsa051331.26977940
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.26775092
30Platelet activation_Homo sapiens_hsa046111.26402133
31Antigen processing and presentation_Homo sapiens_hsa046121.24617322
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23578812
33Influenza A_Homo sapiens_hsa051641.20013112
34Type II diabetes mellitus_Homo sapiens_hsa049301.18727122
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14695663
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.14422503
37TNF signaling pathway_Homo sapiens_hsa046681.13390855
38Dilated cardiomyopathy_Homo sapiens_hsa054141.11824726
39VEGF signaling pathway_Homo sapiens_hsa043701.11596098
40Apoptosis_Homo sapiens_hsa042101.08689188
41Allograft rejection_Homo sapiens_hsa053301.07196384
42Insulin resistance_Homo sapiens_hsa049311.03796751
43Hepatitis B_Homo sapiens_hsa051611.01616764
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.00046854
45Malaria_Homo sapiens_hsa051440.99864734
46Endometrial cancer_Homo sapiens_hsa052130.99216425
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98899998
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97483550
49Non-small cell lung cancer_Homo sapiens_hsa052230.97006020
50Herpes simplex infection_Homo sapiens_hsa051680.96385412
51Shigellosis_Homo sapiens_hsa051310.94999786
52Pancreatic cancer_Homo sapiens_hsa052120.93447070
53Salmonella infection_Homo sapiens_hsa051320.92668647
54Legionellosis_Homo sapiens_hsa051340.92060387
55Choline metabolism in cancer_Homo sapiens_hsa052310.91692216
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89222764
57Oxytocin signaling pathway_Homo sapiens_hsa049210.88836196
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.86315797
59MAPK signaling pathway_Homo sapiens_hsa040100.85719036
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84500778
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83816440
62ErbB signaling pathway_Homo sapiens_hsa040120.83754525
63mTOR signaling pathway_Homo sapiens_hsa041500.83415407
64Graft-versus-host disease_Homo sapiens_hsa053320.82351516
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78997788
66Prolactin signaling pathway_Homo sapiens_hsa049170.78988329
67Inositol phosphate metabolism_Homo sapiens_hsa005620.78618929
68Lysosome_Homo sapiens_hsa041420.77788770
69HIF-1 signaling pathway_Homo sapiens_hsa040660.77415192
70Renal cell carcinoma_Homo sapiens_hsa052110.77306771
71Phagosome_Homo sapiens_hsa041450.76047002
72African trypanosomiasis_Homo sapiens_hsa051430.76045355
73Other glycan degradation_Homo sapiens_hsa005110.75939741
74Gastric acid secretion_Homo sapiens_hsa049710.75722929
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.75134183
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75047290
77Olfactory transduction_Homo sapiens_hsa047400.74254406
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72822114
79Asthma_Homo sapiens_hsa053100.71609409
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69274212
81Dorso-ventral axis formation_Homo sapiens_hsa043200.68798162
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.68345961
83Long-term potentiation_Homo sapiens_hsa047200.68312094
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68152597
85Viral carcinogenesis_Homo sapiens_hsa052030.67801232
86Endocytosis_Homo sapiens_hsa041440.67754481
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67460851
88Glioma_Homo sapiens_hsa052140.66994522
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66563555
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64734178
91Insulin signaling pathway_Homo sapiens_hsa049100.63802253
92Prion diseases_Homo sapiens_hsa050200.63080664
93Bladder cancer_Homo sapiens_hsa052190.62592181
94Calcium signaling pathway_Homo sapiens_hsa040200.61879366
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61707264
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61510424
97Morphine addiction_Homo sapiens_hsa050320.61363062
98Prostate cancer_Homo sapiens_hsa052150.61259342
99Thyroid cancer_Homo sapiens_hsa052160.60965412
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60768200
101Hepatitis C_Homo sapiens_hsa051600.60384016
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60300454
103Colorectal cancer_Homo sapiens_hsa052100.59979348
104Renin secretion_Homo sapiens_hsa049240.59957774
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.59628529
106FoxO signaling pathway_Homo sapiens_hsa040680.59568595
107HTLV-I infection_Homo sapiens_hsa051660.58453165
108Epstein-Barr virus infection_Homo sapiens_hsa051690.58375577
109Amoebiasis_Homo sapiens_hsa051460.58304300
110Notch signaling pathway_Homo sapiens_hsa043300.57669113
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57270782
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57029807
113GnRH signaling pathway_Homo sapiens_hsa049120.56792294
114Cholinergic synapse_Homo sapiens_hsa047250.56682801
115Estrogen signaling pathway_Homo sapiens_hsa049150.56440944
116Rheumatoid arthritis_Homo sapiens_hsa053230.54172699
117Type I diabetes mellitus_Homo sapiens_hsa049400.51790328
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51344208

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