DENND2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)5.05318804
2keratinization (GO:0031424)4.88611600
3ketone body metabolic process (GO:1902224)4.55954031
4regulation of skeletal muscle contraction (GO:0014819)4.47302751
5regulation of posttranscriptional gene silencing (GO:0060147)4.39079036
6regulation of gene silencing by miRNA (GO:0060964)4.39079036
7regulation of gene silencing by RNA (GO:0060966)4.39079036
8regulation of hexokinase activity (GO:1903299)3.93220737
9regulation of glucokinase activity (GO:0033131)3.93220737
10actin-myosin filament sliding (GO:0033275)3.90486355
11muscle filament sliding (GO:0030049)3.90486355
12regulation of helicase activity (GO:0051095)3.90002587
13nuclear pore organization (GO:0006999)3.89171960
14nuclear pore complex assembly (GO:0051292)3.87932143
15protein K11-linked deubiquitination (GO:0035871)3.85278640
16interferon-gamma secretion (GO:0072643)3.80811772
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.78313423
18regulation of telomere maintenance via telomerase (GO:0032210)3.66781626
19protein K6-linked ubiquitination (GO:0085020)3.63031172
20DNA replication initiation (GO:0006270)3.58811904
21high-density lipoprotein particle remodeling (GO:0034375)3.58097028
22detection of light stimulus involved in visual perception (GO:0050908)3.57924403
23detection of light stimulus involved in sensory perception (GO:0050962)3.57924403
24behavioral response to nicotine (GO:0035095)3.56379966
25regulation of relaxation of muscle (GO:1901077)3.53138103
26somatic hypermutation of immunoglobulin genes (GO:0016446)3.51500791
27somatic diversification of immune receptors via somatic mutation (GO:0002566)3.51500791
28maturation of SSU-rRNA (GO:0030490)3.49876622
29platelet dense granule organization (GO:0060155)3.46975439
30actin-mediated cell contraction (GO:0070252)3.42319769
31protein localization to kinetochore (GO:0034501)3.41046560
32sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40192018
33DNA replication checkpoint (GO:0000076)3.37965079
34establishment of skin barrier (GO:0061436)3.37871498
35histone H4-K12 acetylation (GO:0043983)3.35173656
36establishment of protein localization to Golgi (GO:0072600)3.31224683
37kinetochore organization (GO:0051383)3.31180559
38reverse cholesterol transport (GO:0043691)3.26837069
39determination of adult lifespan (GO:0008340)3.25480392
40pore complex assembly (GO:0046931)3.24177196
41kinetochore assembly (GO:0051382)3.21951768
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21845587
43hemidesmosome assembly (GO:0031581)3.21272189
44mitotic metaphase plate congression (GO:0007080)3.19063369
45phospholipid homeostasis (GO:0055091)3.18047160
46keratinocyte development (GO:0003334)3.16998383
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12413757
48skeletal muscle contraction (GO:0003009)3.11947043
49meiotic chromosome segregation (GO:0045132)3.11936638
50sperm motility (GO:0030317)3.10852470
51microtubule depolymerization (GO:0007019)3.09290971
52response to pheromone (GO:0019236)3.08988025
53desmosome organization (GO:0002934)3.08973096
54protein localization to chromosome, centromeric region (GO:0071459)3.07416796
55mitotic sister chromatid segregation (GO:0000070)3.06606689
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05893939
57kynurenine metabolic process (GO:0070189)3.05233868
58ribonucleoprotein complex biogenesis (GO:0022613)3.05109503
59regulation of water loss via skin (GO:0033561)3.01460043
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00796481
61chromatin remodeling at centromere (GO:0031055)3.00000287
62replication fork processing (GO:0031297)2.98480686
63negative regulation of DNA-dependent DNA replication (GO:2000104)2.98202065
64DNA replication-dependent nucleosome assembly (GO:0006335)2.96223447
65DNA replication-dependent nucleosome organization (GO:0034723)2.96223447
66ribosomal small subunit biogenesis (GO:0042274)2.94725321
67L-fucose catabolic process (GO:0042355)2.94570398
68fucose catabolic process (GO:0019317)2.94570398
69L-fucose metabolic process (GO:0042354)2.94570398
70indolalkylamine metabolic process (GO:0006586)2.94360707
71CENP-A containing nucleosome assembly (GO:0034080)2.91482858
72metaphase plate congression (GO:0051310)2.91380592
73multicellular organism reproduction (GO:0032504)2.91289972
74axoneme assembly (GO:0035082)2.90696826
75regulation of gene silencing (GO:0060968)2.90319873
76ribosome biogenesis (GO:0042254)2.90243391
77paraxial mesoderm development (GO:0048339)2.89774163
78tryptophan catabolic process (GO:0006569)2.88124924
79indole-containing compound catabolic process (GO:0042436)2.88124924
80indolalkylamine catabolic process (GO:0046218)2.88124924
81DNA integration (GO:0015074)2.88074817
82DNA double-strand break processing (GO:0000729)2.87059072
83ribosomal large subunit biogenesis (GO:0042273)2.87041574
84neuronal action potential propagation (GO:0019227)2.86759422
85regulation of double-strand break repair via homologous recombination (GO:0010569)2.86133691
86protein targeting to Golgi (GO:0000042)2.85688031
87regulation of histone H3-K9 methylation (GO:0051570)2.85390237
88nephron epithelium morphogenesis (GO:0072088)2.85124002
89nephron tubule morphogenesis (GO:0072078)2.85124002
90ribosomal small subunit assembly (GO:0000028)2.84743277
91regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81100129
92mismatch repair (GO:0006298)2.76784963
93regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76462684
94notochord development (GO:0030903)2.76205492
95telomere maintenance via semi-conservative replication (GO:0032201)2.75052098
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.74860438
97otic vesicle formation (GO:0030916)2.74654823
98phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74249359
99DNA strand renaturation (GO:0000733)2.72506996
100cellular biogenic amine catabolic process (GO:0042402)2.71820475
101amine catabolic process (GO:0009310)2.71820475
102DNA strand elongation involved in DNA replication (GO:0006271)2.71711918
103IMP biosynthetic process (GO:0006188)2.71570759
104dopamine transport (GO:0015872)2.71007567
105positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70047055
106formation of translation preinitiation complex (GO:0001731)2.69957893
107protein K63-linked deubiquitination (GO:0070536)2.69931658
108DNA geometric change (GO:0032392)2.69618597
109myofibril assembly (GO:0030239)2.69144058
110lipoxygenase pathway (GO:0019372)2.68593975
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68533422
112DNA duplex unwinding (GO:0032508)2.68219858
113cilium or flagellum-dependent cell motility (GO:0001539)2.67443072
114glycerophospholipid catabolic process (GO:0046475)2.67153892
115regulation of double-strand break repair (GO:2000779)2.66468635
116acrosome reaction (GO:0007340)2.66153753
117ubiquinone biosynthetic process (GO:0006744)2.66142849
118regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.65990804
119sister chromatid segregation (GO:0000819)2.65463978
120positive regulation of DNA-dependent DNA replication (GO:2000105)2.65432095
121mitotic nuclear envelope disassembly (GO:0007077)2.64955268
122DNA strand elongation (GO:0022616)2.63641409
123phospholipid efflux (GO:0033700)2.62498250
124epithelial cilium movement (GO:0003351)2.62102755
125reflex (GO:0060004)2.62069560
126drug catabolic process (GO:0042737)2.61972850
127exogenous drug catabolic process (GO:0042738)2.61643505
128regulation of mesoderm development (GO:2000380)2.61538190
129viral transcription (GO:0019083)2.60006252
130negative regulation of histone methylation (GO:0031061)2.59915140
131DNA replication-independent nucleosome organization (GO:0034724)2.59858507
132DNA replication-independent nucleosome assembly (GO:0006336)2.59858507
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.59777074
134sulfation (GO:0051923)2.59703193
135intra-S DNA damage checkpoint (GO:0031573)2.59254491
136attachment of spindle microtubules to kinetochore (GO:0008608)2.58407878
137retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57165777
138telomere maintenance via telomere lengthening (GO:0010833)2.56628147
139establishment of chromosome localization (GO:0051303)2.55885517
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.55065358
141translational termination (GO:0006415)2.54708368
142regulation of hippo signaling (GO:0035330)2.54399339
143neural tube formation (GO:0001841)2.53841437
144piRNA metabolic process (GO:0034587)2.53432681
145tryptophan metabolic process (GO:0006568)2.53307611
146negative regulation of androgen receptor signaling pathway (GO:0060766)2.52389081
147regulation of DNA-dependent DNA replication (GO:0090329)2.52172791
148response to muscle activity (GO:0014850)2.51899937
149negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51857921
150spindle checkpoint (GO:0031577)2.49145492
151plasma membrane repair (GO:0001778)2.48896490
152mitotic G2/M transition checkpoint (GO:0044818)2.48750178
153positive regulation of sodium ion transmembrane transport (GO:1902307)2.48613676
154positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.48274623
155positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.48274623
156positive regulation of mitotic sister chromatid separation (GO:1901970)2.48274623
157regulation of histone H3-K27 methylation (GO:0061085)2.47701183
158adenosine metabolic process (GO:0046085)2.47486743
159photoreceptor cell maintenance (GO:0045494)2.47358949
160telomere maintenance via recombination (GO:0000722)2.46967086
161magnesium ion transport (GO:0015693)2.46790310
162amino-acid betaine transport (GO:0015838)2.46523829
163carnitine transport (GO:0015879)2.46523829
164ubiquinone metabolic process (GO:0006743)2.46017931
165regulation of cell communication by electrical coupling (GO:0010649)2.45937171
166mitotic recombination (GO:0006312)2.45557481
167embryonic process involved in female pregnancy (GO:0060136)2.44995645
168membrane disassembly (GO:0030397)2.44909107
169nuclear envelope disassembly (GO:0051081)2.44909107
170negative regulation of telomere maintenance (GO:0032205)2.44503754
171phosphatidylserine acyl-chain remodeling (GO:0036150)2.44100860
172regulation of chemokine secretion (GO:0090196)2.43827778
173regulation of DNA endoreduplication (GO:0032875)2.43710279
174auditory receptor cell stereocilium organization (GO:0060088)2.43598025
175myotube cell development (GO:0014904)2.43551368
176heterochromatin organization (GO:0070828)2.42882183
177nucleobase biosynthetic process (GO:0046112)2.42823039
178cornea development in camera-type eye (GO:0061303)2.42779392
179aspartate family amino acid catabolic process (GO:0009068)2.42698599
180rRNA processing (GO:0006364)2.42304053
181regulation of action potential (GO:0098900)2.41993138
182protein localization to Golgi apparatus (GO:0034067)2.41839666
183embryonic camera-type eye development (GO:0031076)2.40902764
184regulation of centrosome cycle (GO:0046605)2.40422611
185neuronal action potential (GO:0019228)2.40214184
186negative regulation of chromosome segregation (GO:0051985)2.37741910
187arginine catabolic process (GO:0006527)2.37645715
188renal tubule morphogenesis (GO:0061333)2.37176421
189thyroid hormone metabolic process (GO:0042403)2.36970553
190membrane depolarization during action potential (GO:0086010)2.36689282
191rRNA metabolic process (GO:0016072)2.36290046
192positive regulation of meiotic cell cycle (GO:0051446)2.36223894
193regulation of sarcomere organization (GO:0060297)2.35036752
194response to inactivity (GO:0014854)2.34437461
195somite development (GO:0061053)2.33978227
196sarcomere organization (GO:0045214)2.33877995
197calcium ion import (GO:0070509)2.32928590
198membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32819901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.35487156
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.60661420
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.28916403
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.28916403
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.28916403
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.05446049
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66016669
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.17950847
9ZNF274_21170338_ChIP-Seq_K562_Hela3.11986873
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02735615
11VDR_22108803_ChIP-Seq_LS180_Human2.87928084
12GBX2_23144817_ChIP-Seq_PC3_Human2.86966483
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82659753
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68527533
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53810975
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52012522
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48043058
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.44174371
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43184283
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.41921019
21* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.34703298
22* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.25285536
23FUS_26573619_Chip-Seq_HEK293_Human2.25061688
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24020520
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.23525514
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21944626
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16420023
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.15291401
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.12576180
30TCF3_18692474_ChIP-Seq_MEFs_Mouse2.11602101
31* ER_23166858_ChIP-Seq_MCF-7_Human2.09359118
32* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.09054292
33TAF15_26573619_Chip-Seq_HEK293_Human2.06157006
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05721447
35* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.05671948
36P300_19829295_ChIP-Seq_ESCs_Human2.03863802
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02119528
38IGF1R_20145208_ChIP-Seq_DFB_Human1.97466136
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97243215
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95198011
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94797233
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.92918297
43EZH2_22144423_ChIP-Seq_EOC_Human1.88126753
44SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88096629
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87964206
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.86050790
47* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.83200972
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81523506
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78520647
50BCAT_22108803_ChIP-Seq_LS180_Human1.75719011
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72184453
52* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.71584945
53* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.70644081
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70199413
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70063248
56* SMAD4_21799915_ChIP-Seq_A2780_Human1.68941286
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.67976510
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67730215
59EWS_26573619_Chip-Seq_HEK293_Human1.66199703
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63261912
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62578668
62AR_25329375_ChIP-Seq_VCAP_Human1.62568006
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61863222
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59417477
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.59243599
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.59237297
67* STAT3_23295773_ChIP-Seq_U87_Human1.58566250
68CBP_20019798_ChIP-Seq_JUKART_Human1.58354400
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58354400
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56994722
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56404679
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56252338
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52730291
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.52261149
75TCF4_23295773_ChIP-Seq_U87_Human1.52108890
76NANOG_19829295_ChIP-Seq_ESCs_Human1.51535817
77SOX2_19829295_ChIP-Seq_ESCs_Human1.51535817
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51380468
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.46678439
80KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46390866
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45901003
82ELK1_19687146_ChIP-ChIP_HELA_Human1.45350657
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44881301
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43561222
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43431285
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42967114
87AR_21572438_ChIP-Seq_LNCaP_Human1.42272782
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.41623841
89* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41517168
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41102598
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40575489
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.39877685
93TTF2_22483619_ChIP-Seq_HELA_Human1.39199290
94TCF4_22108803_ChIP-Seq_LS180_Human1.38994744
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38293570
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.37828779
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37353735
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36839716
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36839716
100CDX2_22108803_ChIP-Seq_LS180_Human1.34982477
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34942415
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34932654
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34044442
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33789843
105TP53_16413492_ChIP-PET_HCT116_Human1.31745763
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30409175
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29901316
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.29280950
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29198486
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28993769
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28731935
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.28309904
113* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26342342
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26253509
115VDR_23849224_ChIP-Seq_CD4+_Human1.26013289
116XRN2_22483619_ChIP-Seq_HELA_Human1.25287028
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24794610
118CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23502410
119AR_21909140_ChIP-Seq_LNCAP_Human1.22991112
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22677339
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22361176
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20947007
123FOXA1_27270436_Chip-Seq_PROSTATE_Human1.20841035
124FOXA1_25329375_ChIP-Seq_VCAP_Human1.20841035
125EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20652257
126P53_22387025_ChIP-Seq_ESCs_Mouse1.19561025
127POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19484358
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18965661
129* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18936216
130* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18549021
131* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17806617
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17268198
133GABP_17652178_ChIP-ChIP_JURKAT_Human1.17242553
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17007630
135* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16954808
136FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16874881
137ESR1_20079471_ChIP-ChIP_T-47D_Human1.16427938
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.16201350
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15116009
140* ETV1_20927104_ChIP-Seq_GIST48_Human1.14080585
141* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13767416
142OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13713108
143SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13666827
144IRF1_19129219_ChIP-ChIP_H3396_Human1.13623560
145SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13319288
146E2F1_18555785_Chip-Seq_ESCs_Mouse1.13230134
147RUNX2_22187159_ChIP-Seq_PCA_Human1.12756581
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12208720
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12176805
150TP53_22573176_ChIP-Seq_HFKS_Human1.11493684
151FOXP3_21729870_ChIP-Seq_TREG_Human1.11447657
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.11304300
153* PHF8_20622853_ChIP-Seq_HELA_Human1.11044311
154BP1_19119308_ChIP-ChIP_Hs578T_Human1.10975649
155BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10313124
156JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10075241
157* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09734370
158HOXB7_26014856_ChIP-Seq_BT474_Human1.09264886
159* RBPJ_21746931_ChIP-Seq_IB4_Human1.07657600
160* TBL1_22424771_ChIP-Seq_293T_Human1.07540186
161CJUN_26792858_Chip-Seq_BT549_Human1.06884612
162ETS1_20019798_ChIP-Seq_JURKAT_Human1.06427769
163* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05664527
164PRDM14_20953172_ChIP-Seq_ESCs_Human1.05137957
165TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04840973
166HTT_18923047_ChIP-ChIP_STHdh_Human1.04745106
167* NCOR_22424771_ChIP-Seq_293T_Human1.04313573
168YY1_21170310_ChIP-Seq_MESCs_Mouse1.04236287
169SMAD3_21741376_ChIP-Seq_HESCs_Human1.03740310
170* NFYB_21822215_ChIP-Seq_K562_Human1.03722446
171YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03341450
172ARNT_22903824_ChIP-Seq_MCF-7_Human1.03213239
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03187352
174* GATA6_21074721_ChIP-Seq_CACO-2_Human1.02725196
175NANOG_16153702_ChIP-ChIP_HESCs_Human1.02057112
176PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01227831
177HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00467659
178* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97321582
179NANOG_21062744_ChIP-ChIP_HESCs_Human0.96776387
180KAP1_27257070_Chip-Seq_ESCs_Mouse0.92977998
181STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92293319
182SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92108788
183* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90118329
184DCP1A_22483619_ChIP-Seq_HELA_Human0.89525246
185HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88476507
186OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86790550
187* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82914756
188ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82560159
189TFEB_21752829_ChIP-Seq_HELA_Human0.82416529
190HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82338471
191SOX2_16153702_ChIP-ChIP_HESCs_Human0.80768718
192PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80018238
193EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78774506
194NANOG_16518401_ChIP-PET_MESCs_Mouse0.77469724
195* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76126542
196TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75737791
197HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74502464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.04393627
2MP0004145_abnormal_muscle_electrophysio4.15182683
3MP0003941_abnormal_skin_development3.92871749
4MP0008057_abnormal_DNA_replication3.56952278
5MP0010094_abnormal_chromosome_stability3.19232259
6MP0003111_abnormal_nucleus_morphology3.03118207
7MP0000566_synostosis2.92629247
8MP0000749_muscle_degeneration2.61426866
9MP0003693_abnormal_embryo_hatching2.57160837
10MP0002837_dystrophic_cardiac_calcinosis2.54852814
11MP0008058_abnormal_DNA_repair2.50496658
12MP0004957_abnormal_blastocyst_morpholog2.45723809
13MP0002796_impaired_skin_barrier2.41020946
14MP0003136_yellow_coat_color2.38132302
15MP0004381_abnormal_hair_follicle2.35596820
16MP0000383_abnormal_hair_follicle2.33613894
17MP0003077_abnormal_cell_cycle2.33477342
18MP0004036_abnormal_muscle_relaxation2.28795682
19MP0004043_abnormal_pH_regulation2.16427892
20MP0005551_abnormal_eye_electrophysiolog2.12757701
21MP0003195_calcinosis2.06104649
22MP0004215_abnormal_myocardial_fiber2.05796526
23MP0002254_reproductive_system_inflammat2.03937182
24MP0004084_abnormal_cardiac_muscle2.03829828
25MP0003786_premature_aging2.03687312
26MP0010030_abnormal_orbit_morphology2.01201294
27MP0001986_abnormal_taste_sensitivity2.00110756
28MP0000372_irregular_coat_pigmentation1.99642088
29MP0008007_abnormal_cellular_replicative1.99586035
30MP0010352_gastrointestinal_tract_polyps1.96721324
31MP0000569_abnormal_digit_pigmentation1.89702858
32MP0003453_abnormal_keratinocyte_physiol1.88386118
33MP0003950_abnormal_plasma_membrane1.88321582
34MP0005410_abnormal_fertilization1.85534168
35MP0005501_abnormal_skin_physiology1.84893944
36MP0006292_abnormal_olfactory_placode1.84654821
37MP0002876_abnormal_thyroid_physiology1.83406716
38MP0005620_abnormal_muscle_contractility1.78802977
39MP0002009_preneoplasia1.77153482
40MP0004130_abnormal_muscle_cell1.71430402
41MP0002106_abnormal_muscle_physiology1.69356895
42MP0002277_abnormal_respiratory_mucosa1.66944746
43MP0002098_abnormal_vibrissa_morphology1.65472398
44MP0008872_abnormal_physiological_respon1.64493731
45MP0004142_abnormal_muscle_tone1.61508007
46MP0002332_abnormal_exercise_endurance1.61034328
47MP0003011_delayed_dark_adaptation1.58210691
48MP0005084_abnormal_gallbladder_morpholo1.56601373
49MP0010329_abnormal_lipoprotein_level1.53868490
50MP0000467_abnormal_esophagus_morphology1.52615457
51MP0000762_abnormal_tongue_morphology1.50600377
52MP0008932_abnormal_embryonic_tissue1.49502899
53MP0001216_abnormal_epidermal_layer1.47929742
54MP0005369_muscle_phenotype1.46811799
55MP0010678_abnormal_skin_adnexa1.45493786
56MP0002060_abnormal_skin_morphology1.42114369
57MP0000350_abnormal_cell_proliferation1.41755804
58MP0002638_abnormal_pupillary_reflex1.41599873
59MP0000647_abnormal_sebaceous_gland1.40902207
60MP0002138_abnormal_hepatobiliary_system1.38412096
61MP0004484_altered_response_of1.38156498
62MP0005076_abnormal_cell_differentiation1.36260579
63MP0008877_abnormal_DNA_methylation1.36059401
64MP0003566_abnormal_cell_adhesion1.34119435
65MP0010307_abnormal_tumor_latency1.33278611
66MP0005253_abnormal_eye_physiology1.32562055
67MP0001293_anophthalmia1.32347651
68MP0000751_myopathy1.31488572
69MP0008775_abnormal_heart_ventricle1.30758766
70MP0005645_abnormal_hypothalamus_physiol1.30746262
71MP0005670_abnormal_white_adipose1.28244669
72MP0002269_muscular_atrophy1.27630407
73MP0002102_abnormal_ear_morphology1.26531396
74MP0001984_abnormal_olfaction1.24013632
75MP0002396_abnormal_hematopoietic_system1.23570954
76MP0001672_abnormal_embryogenesis/_devel1.23420207
77MP0005380_embryogenesis_phenotype1.23420207
78MP0006036_abnormal_mitochondrial_physio1.22457265
79MP0008875_abnormal_xenobiotic_pharmacok1.20983656
80MP0002972_abnormal_cardiac_muscle1.20197586
81MP0002132_abnormal_respiratory_system1.18304293
82MP0009046_muscle_twitch1.17958427
83MP0003890_abnormal_embryonic-extraembry1.17279628
84MP0003787_abnormal_imprinting1.15016326
85MP0004885_abnormal_endolymph1.14606099
86MP0005266_abnormal_metabolism1.14248589
87MP0000516_abnormal_urinary_system1.14132692
88MP0005367_renal/urinary_system_phenotyp1.14132692
89MP0004133_heterotaxia1.13709790
90MP0000490_abnormal_crypts_of1.13432025
91MP0002086_abnormal_extraembryonic_tissu1.13351143
92MP0002085_abnormal_embryonic_tissue1.13252996
93MP0003718_maternal_effect1.11944719
94MP0002084_abnormal_developmental_patter1.11475483
95MP0006072_abnormal_retinal_apoptosis1.11134623
96MP0008995_early_reproductive_senescence1.11030438
97MP0004264_abnormal_extraembryonic_tissu1.10933275
98MP0002111_abnormal_tail_morphology1.10556135
99MP0002736_abnormal_nociception_after1.09740588
100MP0002127_abnormal_cardiovascular_syste1.08860432
101MP0004197_abnormal_fetal_growth/weight/1.08740410
102MP0001485_abnormal_pinna_reflex1.08508151
103MP0000377_abnormal_hair_follicle1.06716891
104MP0001501_abnormal_sleep_pattern1.06685273
105MP0009780_abnormal_chondrocyte_physiolo1.06519215
106MP0000750_abnormal_muscle_regeneration1.06479809
107MP0002938_white_spotting1.06144826
108MP0003137_abnormal_impulse_conducting1.05606047
109MP0002095_abnormal_skin_pigmentation1.05451473
110MP0005332_abnormal_amino_acid1.05168976
111MP0001968_abnormal_touch/_nociception1.04068060
112MP0005075_abnormal_melanosome_morpholog1.03063458
113MP0001191_abnormal_skin_condition1.02970823
114MP0000230_abnormal_systemic_arterial1.02390215
115MP0005085_abnormal_gallbladder_physiolo1.02182817
116MP0010771_integument_phenotype1.01789967
117MP0003315_abnormal_perineum_morphology1.01080458
118MP0001286_abnormal_eye_development1.00650538
119MP0003755_abnormal_palate_morphology1.00603619
120MP0004087_abnormal_muscle_fiber1.00307820
121MP0005174_abnormal_tail_pigmentation1.00085718
122MP0003828_pulmonary_edema0.99255471
123MP0003937_abnormal_limbs/digits/tail_de0.98729503
124MP0000432_abnormal_head_morphology0.98535722
125MP0005275_abnormal_skin_tensile0.98183069
126MP0004085_abnormal_heartbeat0.97410803
127MP0003984_embryonic_growth_retardation0.96772561
128MP0006276_abnormal_autonomic_nervous0.96279204
129MP0004147_increased_porphyrin_level0.96169968
130MP0002088_abnormal_embryonic_growth/wei0.95945377
131MP0005377_hearing/vestibular/ear_phenot0.95769620
132MP0003878_abnormal_ear_physiology0.95769620
133MP0000579_abnormal_nail_morphology0.93508398
134MP0001188_hyperpigmentation0.93347061
135MP0002249_abnormal_larynx_morphology0.93233505
136MP0002160_abnormal_reproductive_system0.92846103
137MP0003448_altered_tumor_morphology0.91747312
138MP0008789_abnormal_olfactory_epithelium0.90980527
139MP0002234_abnormal_pharynx_morphology0.90719544
140MP0005646_abnormal_pituitary_gland0.88471725
141MP0005330_cardiomyopathy0.88293635
142MP0005167_abnormal_blood-brain_barrier0.87971971
143MP0003698_abnormal_male_reproductive0.87762846
144MP0001697_abnormal_embryo_size0.87671368
145MP0005023_abnormal_wound_healing0.86689429
146MP0002210_abnormal_sex_determination0.86142852
147MP0002697_abnormal_eye_size0.85621292
148MP0003121_genomic_imprinting0.85465896
149MP0002653_abnormal_ependyma_morphology0.85230397
150MP0001346_abnormal_lacrimal_gland0.85037615
151MP0009745_abnormal_behavioral_response0.84808128
152MP0005499_abnormal_olfactory_system0.84487698
153MP0005394_taste/olfaction_phenotype0.84487698
154MP0003119_abnormal_digestive_system0.84417842
155MP0000858_altered_metastatic_potential0.84320954
156MP0002108_abnormal_muscle_morphology0.84157305
157MP0001186_pigmentation_phenotype0.83685443
158MP0001730_embryonic_growth_arrest0.83430075
159MP0000313_abnormal_cell_death0.82893362
160MP0001486_abnormal_startle_reflex0.82160494
161MP0005365_abnormal_bile_salt0.81295397
162MP0003567_abnormal_fetal_cardiomyocyte0.81138504
163MP0000759_abnormal_skeletal_muscle0.81128356
164MP0003705_abnormal_hypodermis_morpholog0.81085577
165MP0002877_abnormal_melanocyte_morpholog0.80877610
166MP0009053_abnormal_anal_canal0.79918222
167MP0005389_reproductive_system_phenotype0.79597741
168MP0000627_abnormal_mammary_gland0.79034879
169MP0004019_abnormal_vitamin_homeostasis0.78547093
170MP0002233_abnormal_nose_morphology0.78388924
171MP0003638_abnormal_response/metabolism_0.78307546
172MP0000427_abnormal_hair_cycle0.77828944
173MP0002092_abnormal_eye_morphology0.77732395
174MP0000631_abnormal_neuroendocrine_gland0.77544666
175MP0002075_abnormal_coat/hair_pigmentati0.77353625
176MP0005257_abnormal_intraocular_pressure0.76144366
177MP0009931_abnormal_skin_appearance0.75347878
178MP0005508_abnormal_skeleton_morphology0.75152290
179MP0003938_abnormal_ear_development0.75047323
180MP0000013_abnormal_adipose_tissue0.74488087
181MP0002272_abnormal_nervous_system0.73780787
182MP0002734_abnormal_mechanical_nocicepti0.72852357
183MP0001929_abnormal_gametogenesis0.70282053
184MP0009697_abnormal_copulation0.70203622

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.57210945
2Nemaline bodies (HP:0003798)5.48008196
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.26468354
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.18630577
5Chromsome breakage (HP:0040012)4.82137157
6Muscle hypertrophy of the lower extremities (HP:0008968)3.78281851
7Chronic hepatic failure (HP:0100626)3.70689015
8Exercise-induced muscle cramps (HP:0003710)3.63614048
9Lip pit (HP:0100267)3.57563910
10Calf muscle hypertrophy (HP:0008981)3.47672386
11Reticulocytopenia (HP:0001896)3.31365074
12Abnormality of the preputium (HP:0100587)3.29470647
13Agnosia (HP:0010524)3.24530150
14Congenital stationary night blindness (HP:0007642)3.15768404
15Meckel diverticulum (HP:0002245)3.11145590
16Type 1 muscle fiber predominance (HP:0003803)3.08286459
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.07620328
18Pancreatic cysts (HP:0001737)3.07294677
19Abnormality of the ileum (HP:0001549)3.06949832
20Exercise-induced myalgia (HP:0003738)3.05945809
21Abnormality of the renal cortex (HP:0011035)3.01285368
22Duplicated collecting system (HP:0000081)3.01029412
23Ependymoma (HP:0002888)3.00222886
24Molar tooth sign on MRI (HP:0002419)2.98191725
25Abnormality of midbrain morphology (HP:0002418)2.98191725
26Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92622099
27Abnormality of alanine metabolism (HP:0010916)2.92622099
28Hyperalaninemia (HP:0003348)2.92622099
29Abnormality of the salivary glands (HP:0010286)2.86643101
30Abnormality of the renal collecting system (HP:0004742)2.83622284
31Absent radius (HP:0003974)2.82654830
32Abnormality of chromosome stability (HP:0003220)2.74803906
33Thick nail (HP:0001805)2.74208227
34Pancreatic fibrosis (HP:0100732)2.73373800
35Supernumerary spleens (HP:0009799)2.72487895
36Abnormality of nail color (HP:0100643)2.72245693
37Abnormality of the labia minora (HP:0012880)2.70346394
38Hypotrichosis (HP:0001006)2.70046582
39Rib fusion (HP:0000902)2.67555049
40Absent forearm bone (HP:0003953)2.63707351
41Aplasia involving forearm bones (HP:0009822)2.63707351
42Type II lissencephaly (HP:0007260)2.62786323
43Renal cortical cysts (HP:0000803)2.62055475
44Ectopic kidney (HP:0000086)2.61748491
45Birth length less than 3rd percentile (HP:0003561)2.58167249
46Distal arthrogryposis (HP:0005684)2.58055258
47Selective tooth agenesis (HP:0001592)2.56291212
48Absent thumb (HP:0009777)2.55324097
49Breast hypoplasia (HP:0003187)2.54696193
50Medulloblastoma (HP:0002885)2.53573784
51Nephronophthisis (HP:0000090)2.49964479
52Polydipsia (HP:0001959)2.48438991
53Abnormal drinking behavior (HP:0030082)2.48438991
54Esophageal atresia (HP:0002032)2.47448182
55Duodenal stenosis (HP:0100867)2.45191409
56Small intestinal stenosis (HP:0012848)2.45191409
57True hermaphroditism (HP:0010459)2.44545015
58Hyperkalemia (HP:0002153)2.43971986
59Duplication of thumb phalanx (HP:0009942)2.42765371
60Hyperventilation (HP:0002883)2.41799827
61Distal lower limb muscle weakness (HP:0009053)2.40977044
62Aplasia cutis congenita (HP:0001057)2.39039635
63Impulsivity (HP:0100710)2.32379353
64Cerebellar dysplasia (HP:0007033)2.29482023
65Rhabdomyosarcoma (HP:0002859)2.29206840
66Hypochromic microcytic anemia (HP:0004840)2.28585828
67Abnormality of the calf musculature (HP:0001430)2.27263508
68Fatigable weakness (HP:0003473)2.27089558
69Abnormality of the neuromuscular junction (HP:0003398)2.27089558
70Abnormality of the renal medulla (HP:0100957)2.27033254
71Rectovaginal fistula (HP:0000143)2.23355893
72Rectal fistula (HP:0100590)2.23355893
73Prostate neoplasm (HP:0100787)2.22342123
74Triphalangeal thumb (HP:0001199)2.22232711
75Nephroblastoma (Wilms tumor) (HP:0002667)2.22056262
7611 pairs of ribs (HP:0000878)2.21684895
77Colon cancer (HP:0003003)2.21592039
78Attenuation of retinal blood vessels (HP:0007843)2.21427476
79Fair hair (HP:0002286)2.20888815
80Milia (HP:0001056)2.20163973
81Abnormality of the astrocytes (HP:0100707)2.20016726
82Astrocytoma (HP:0009592)2.20016726
83Abnormal number of incisors (HP:0011064)2.19208492
84Furrowed tongue (HP:0000221)2.18569766
85Absent phalangeal crease (HP:0006109)2.17140166
86Clubbing of toes (HP:0100760)2.16233923
87Hypomagnesemia (HP:0002917)2.16213634
88Plantar hyperkeratosis (HP:0007556)2.15900543
89Erythroderma (HP:0001019)2.14771782
90Sparse scalp hair (HP:0002209)2.14540529
91Large for gestational age (HP:0001520)2.14387698
92Asplenia (HP:0001746)2.13944644
93Tubular atrophy (HP:0000092)2.12876120
94Abolished electroretinogram (ERG) (HP:0000550)2.11499929
95Areflexia of lower limbs (HP:0002522)2.09073322
96Abnormal rod and cone electroretinograms (HP:0008323)2.08959072
97Upper limb muscle weakness (HP:0003484)2.08697629
98Embryonal renal neoplasm (HP:0011794)2.08610581
99Inability to walk (HP:0002540)2.08101186
100Glioma (HP:0009733)2.07734884
101Abnormal finger flexion creases (HP:0006143)2.07480947
102Onycholysis (HP:0001806)2.07156208
103Decreased central vision (HP:0007663)2.05148661
104Myelodysplasia (HP:0002863)2.05079358
105Gastrointestinal atresia (HP:0002589)2.04971281
106Ectropion (HP:0000656)2.04658139
107Congenital, generalized hypertrichosis (HP:0004540)2.04380833
108Intestinal fistula (HP:0100819)2.03886890
109Spontaneous abortion (HP:0005268)2.03222090
110Abnormality of the duodenum (HP:0002246)2.02603483
111Medial flaring of the eyebrow (HP:0010747)2.02506747
112Abnormality of secondary sexual hair (HP:0009888)2.02299405
113Abnormality of the axillary hair (HP:0100134)2.02299405
114Hypoalphalipoproteinemia (HP:0003233)2.01877634
115Supernumerary bones of the axial skeleton (HP:0009144)2.01691919
116Patellar aplasia (HP:0006443)2.01481157
117Alopecia of scalp (HP:0002293)2.00886490
118Aplasia/Hypoplasia of the spleen (HP:0010451)1.99714015
119Sparse eyelashes (HP:0000653)1.99513569
120Septo-optic dysplasia (HP:0100842)1.98484659
121Short thumb (HP:0009778)1.97902939
122Hypoplastic labia majora (HP:0000059)1.95884900
123Neoplasm of the oral cavity (HP:0100649)1.94884973
124Palmar hyperkeratosis (HP:0010765)1.94709663
125Spinal muscular atrophy (HP:0007269)1.94599605
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.93978449
127Rimmed vacuoles (HP:0003805)1.93922855
128Nasolacrimal duct obstruction (HP:0000579)1.93692209
129Hyporeflexia of lower limbs (HP:0002600)1.93327781
130Fragile nails (HP:0001808)1.92941557
131Missing ribs (HP:0000921)1.92940675
132Supernumerary ribs (HP:0005815)1.92584708
133Nail dystrophy (HP:0008404)1.91373329
134Concave nail (HP:0001598)1.91258367
135Chorioretinal atrophy (HP:0000533)1.91250316
136Partial duplication of thumb phalanx (HP:0009944)1.90941250
137Progressive inability to walk (HP:0002505)1.90314466
138Abnormality of the incisor (HP:0000676)1.90097458
139Stenosis of the external auditory canal (HP:0000402)1.89280102
140Dynein arm defect of respiratory motile cilia (HP:0012255)1.88324056
141Absent/shortened dynein arms (HP:0200106)1.88324056
142EMG: myopathic abnormalities (HP:0003458)1.88145546
143Gaze-evoked nystagmus (HP:0000640)1.87468792
144Abnormal sex determination (HP:0012244)1.86746488
145Sex reversal (HP:0012245)1.86746488
146Abnormality of cells of the erythroid lineage (HP:0012130)1.85387937
147Pustule (HP:0200039)1.84997126
148Abnormality of the nasal septum (HP:0000419)1.84758586
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84560243
150Polyuria (HP:0000103)1.83448603
151Bone marrow hypocellularity (HP:0005528)1.83081229
152Aplasia/hypoplasia of the humerus (HP:0006507)1.81776250
153Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.80808236
154Aplasia/Hypoplasia of the patella (HP:0006498)1.80582353
155Hyperglycinuria (HP:0003108)1.79694595
156Abnormality of the carotid arteries (HP:0005344)1.79374513
157Tracheoesophageal fistula (HP:0002575)1.79121737
158Hypolipoproteinemia (HP:0010981)1.78467675
159Myoglobinuria (HP:0002913)1.78153260
160Parakeratosis (HP:0001036)1.77902988
161Broad-based gait (HP:0002136)1.77682243
162Woolly hair (HP:0002224)1.77441735
163Abnormality of the labia majora (HP:0012881)1.77319000
164Acute encephalopathy (HP:0006846)1.77132759
165Increased CSF lactate (HP:0002490)1.76272232
1663-Methylglutaconic aciduria (HP:0003535)1.76122508
167Abnormality of DNA repair (HP:0003254)1.75897218
168Pendular nystagmus (HP:0012043)1.75734507
169Intestinal atresia (HP:0011100)1.75511103
170Palmoplantar hyperkeratosis (HP:0000972)1.75483348
171Muscle fiber splitting (HP:0003555)1.74064993
172Congenital ichthyosiform erythroderma (HP:0007431)1.73991500
173Hypoplasia of the fovea (HP:0007750)1.72846236
174Aplasia/Hypoplasia of the fovea (HP:0008060)1.72846236
175Hypothermia (HP:0002045)1.72016059
176Sloping forehead (HP:0000340)1.70974760
177Neoplasm of striated muscle (HP:0009728)1.70818389
178Popliteal pterygium (HP:0009756)1.70312158
179Hypoplasia of the radius (HP:0002984)1.69196164
180Abnormal lung lobation (HP:0002101)1.68804377
181Acute necrotizing encephalopathy (HP:0006965)1.67962367
182Optic nerve hypoplasia (HP:0000609)1.67889647
183Short humerus (HP:0005792)1.67115115
184Frequent falls (HP:0002359)1.66931043
185Round ear (HP:0100830)1.66577856
186Hypoplasia of the uterus (HP:0000013)1.66130755
187Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65901871
188Keratoconus (HP:0000563)1.65671166
189Increased corneal curvature (HP:0100692)1.65671166
190Facial diplegia (HP:0001349)1.64776089
191Hepatic necrosis (HP:0002605)1.64511544
192Aplasia/hypoplasia of the uterus (HP:0008684)1.62536638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.49834157
2FRK5.19637405
3CDK125.15682868
4EPHA23.66304353
5ZAK3.22281955
6PHKG23.04093992
7PHKG13.04093992
8TTK2.78115766
9PINK12.52333860
10WEE12.40321243
11WNK32.37431238
12IRAK32.31808791
13SRPK12.27273740
14RPS6KB22.20328912
15PIK3CG2.14254010
16MAP4K22.05912162
17TAOK31.99862035
18CDC71.97971040
19CDK71.97708877
20BRD41.94070905
21MAPKAPK31.90866578
22BUB11.87289468
23STK101.84232552
24PLK11.81994959
25BLK1.78204148
26CHEK21.77592771
27EIF2AK21.76240171
28TGFBR21.73906025
29GRK71.71397020
30NUAK11.70490468
31AKT31.63731263
32INSRR1.61087157
33PLK41.54029694
34STK38L1.52447358
35MKNK21.50529723
36VRK11.46835545
37MAPK131.44343232
38IRAK41.41446592
39ATR1.41140579
40MAP3K31.36925260
41PNCK1.36142112
42YES11.35668415
43TLK11.33916364
44MUSK1.33601897
45WNK41.33408561
46NEK21.30246628
47TNIK1.29744010
48DYRK31.29263340
49AURKB1.27658200
50PIM11.23529059
51MKNK11.23407431
52OXSR11.22278120
53MAP3K141.19996135
54PAK31.19498301
55TSSK61.18060331
56STK391.17784049
57TRIM281.13622012
58STK41.13466145
59PLK31.13449285
60CHEK11.12195018
61ADRBK21.09832009
62GRK11.08214967
63PLK21.08145158
64ATM1.06304705
65CDK41.03456394
66AURKA1.02539908
67TRPM70.99244226
68NME10.97888184
69MAPK150.96310706
70PASK0.93427954
71TGFBR10.92990385
72ADRBK10.92600022
73CDK60.91087936
74ACVR1B0.90102730
75MAP2K60.89689445
76PRKCI0.89066920
77BRSK20.88880544
78PRKCE0.88862589
79MAP3K120.88514010
80CDK90.88412562
81MAP3K40.88384956
82IKBKB0.86336607
83TIE10.83758101
84PTK2B0.82060964
85ERBB30.81823769
86PKN10.78717712
87PRKAA20.77708685
88MST40.76863601
89CDK80.76373520
90FER0.75843868
91EIF2AK10.73943166
92MAP3K70.72606480
93NEK90.71197430
94DAPK20.71076846
95NEK60.69372993
96MAPK70.68850374
97GRK50.68847436
98CHUK0.68791387
99TTN0.68225394
100PIK3CA0.68130276
101TYK20.67792952
102STK30.66910265
103CDK20.66539487
104PIM20.65761152
105EEF2K0.65484533
106PRKCG0.64447460
107PRKG10.63099286
108CAMK2A0.60905035
109TAOK20.59738507
110LATS10.58953408
111NEK10.58311089
112MAP2K10.56429372
113SGK20.54100884
114BMPR1B0.53744454
115CDK10.53021690
116CDK30.52379870
117TXK0.52183003
118STK160.50736611
119MARK10.50589753
120MELK0.50005761
121CSNK2A10.49938842
122FGFR20.49845895
123MARK30.49596434
124IRAK10.49261293
125PRKAA10.48853174
126RPS6KA50.48290796
127PRKACA0.48189064
128CAMK10.48089082
129NTRK30.48084738
130CSNK1D0.47940169
131NLK0.46804981
132MAPK120.46098261
133PDK20.45494145
134IRAK20.45451376
135TEC0.45381062
136MAP3K80.45340323
137MAP2K40.44106289
138RPS6KC10.43467842
139RPS6KL10.43467842
140CLK10.43447679
141MAPKAPK50.42844521
142PBK0.42446844
143MATK0.40998298
144MAPKAPK20.40520483
145AKT10.39316576
146RPS6KA40.38590082
147CSNK2A20.38254908
148EIF2AK30.37985944
149STK240.36575838
150MAPK140.36563397
151MAPK10.36363783
152CSNK1A10.35840137
153MTOR0.35103934
154CASK0.34582186
155PRKDC0.33798690
156PRKACB0.33553331
157CSNK1G10.33488007
158PAK40.33143335
159ROCK10.31613076
160PRKCA0.30689314
161PRKCQ0.29886495
162CAMK40.29725746
163CAMK2D0.29589244
164BCR0.29534628
165SGK2230.29076749
166SGK4940.29076749
167CSNK1G20.23820310
168PRKACG0.22741759
169STK110.21978376

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.60439041
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36792582
3DNA replication_Homo sapiens_hsa030303.36118349
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26994495
5Fanconi anemia pathway_Homo sapiens_hsa034603.19377311
6Nitrogen metabolism_Homo sapiens_hsa009102.91702152
7Ribosome_Homo sapiens_hsa030102.76785626
8Homologous recombination_Homo sapiens_hsa034402.71114468
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.69330729
10Butanoate metabolism_Homo sapiens_hsa006502.48755203
11Phototransduction_Homo sapiens_hsa047442.45335559
12RNA transport_Homo sapiens_hsa030132.39702802
13Cell cycle_Homo sapiens_hsa041102.33986004
14Base excision repair_Homo sapiens_hsa034102.32951905
15RNA polymerase_Homo sapiens_hsa030202.32703031
16Spliceosome_Homo sapiens_hsa030402.27542064
17Nucleotide excision repair_Homo sapiens_hsa034202.27098849
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22554934
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21266412
20p53 signaling pathway_Homo sapiens_hsa041152.17495068
21One carbon pool by folate_Homo sapiens_hsa006702.17474390
22Propanoate metabolism_Homo sapiens_hsa006402.14575323
23Non-homologous end-joining_Homo sapiens_hsa034502.13473166
24Basal transcription factors_Homo sapiens_hsa030222.08534072
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.89784464
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77305053
27Circadian rhythm_Homo sapiens_hsa047101.75613117
28Ether lipid metabolism_Homo sapiens_hsa005651.74688574
29Cardiac muscle contraction_Homo sapiens_hsa042601.72561198
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.72056019
31Selenocompound metabolism_Homo sapiens_hsa004501.71796909
32Caffeine metabolism_Homo sapiens_hsa002321.68778420
33RNA degradation_Homo sapiens_hsa030181.65981910
34Fat digestion and absorption_Homo sapiens_hsa049751.65268838
35Arachidonic acid metabolism_Homo sapiens_hsa005901.62332404
36Oxidative phosphorylation_Homo sapiens_hsa001901.62176068
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.61011033
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56619088
39mRNA surveillance pathway_Homo sapiens_hsa030151.55944622
40Tryptophan metabolism_Homo sapiens_hsa003801.55500408
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55428465
42Chemical carcinogenesis_Homo sapiens_hsa052041.51594575
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51569652
44Pyrimidine metabolism_Homo sapiens_hsa002401.46714842
45Systemic lupus erythematosus_Homo sapiens_hsa053221.46421334
46Basal cell carcinoma_Homo sapiens_hsa052171.44440756
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40133057
48Olfactory transduction_Homo sapiens_hsa047401.39765027
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37260130
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36529592
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36499383
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36015721
53Peroxisome_Homo sapiens_hsa041461.33697829
54Retinol metabolism_Homo sapiens_hsa008301.32834746
55Parkinsons disease_Homo sapiens_hsa050121.29791308
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28800902
57Herpes simplex infection_Homo sapiens_hsa051681.28221682
58ABC transporters_Homo sapiens_hsa020101.25601614
59beta-Alanine metabolism_Homo sapiens_hsa004101.24923857
60Fatty acid degradation_Homo sapiens_hsa000711.24778930
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24655346
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22675725
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.19406782
64Notch signaling pathway_Homo sapiens_hsa043301.18677024
65Calcium signaling pathway_Homo sapiens_hsa040201.16297485
66Arginine and proline metabolism_Homo sapiens_hsa003301.13841500
67Histidine metabolism_Homo sapiens_hsa003401.13402701
68Proteasome_Homo sapiens_hsa030501.12727032
69NF-kappa B signaling pathway_Homo sapiens_hsa040641.10894714
70Small cell lung cancer_Homo sapiens_hsa052221.10553066
71Hippo signaling pathway_Homo sapiens_hsa043901.10084638
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08444860
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08395000
74TGF-beta signaling pathway_Homo sapiens_hsa043501.08311885
75MicroRNAs in cancer_Homo sapiens_hsa052061.07600989
76Vitamin digestion and absorption_Homo sapiens_hsa049771.07268557
77Protein export_Homo sapiens_hsa030601.06952970
78Sulfur metabolism_Homo sapiens_hsa009201.03087436
79Epstein-Barr virus infection_Homo sapiens_hsa051691.02513003
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02227091
81Viral carcinogenesis_Homo sapiens_hsa052030.99584382
82Alzheimers disease_Homo sapiens_hsa050100.97748513
83Serotonergic synapse_Homo sapiens_hsa047260.97052675
84HTLV-I infection_Homo sapiens_hsa051660.96892784
85Hedgehog signaling pathway_Homo sapiens_hsa043400.96858177
86Regulation of autophagy_Homo sapiens_hsa041400.96405813
87Adherens junction_Homo sapiens_hsa045200.92826195
88Arginine biosynthesis_Homo sapiens_hsa002200.87880395
89Huntingtons disease_Homo sapiens_hsa050160.87837282
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87484983
91PPAR signaling pathway_Homo sapiens_hsa033200.86999492
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.86826743
93Glycerolipid metabolism_Homo sapiens_hsa005610.84674711
94Hematopoietic cell lineage_Homo sapiens_hsa046400.84465145
95Apoptosis_Homo sapiens_hsa042100.83775176
96Salivary secretion_Homo sapiens_hsa049700.82572133
97Dilated cardiomyopathy_Homo sapiens_hsa054140.81053544
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79811095
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79593247
100Fatty acid elongation_Homo sapiens_hsa000620.79130570
101Other glycan degradation_Homo sapiens_hsa005110.77996186
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77033218
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76574740
104Purine metabolism_Homo sapiens_hsa002300.75992543
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75813682
106Measles_Homo sapiens_hsa051620.75732383
107Antigen processing and presentation_Homo sapiens_hsa046120.75284140
108Pathways in cancer_Homo sapiens_hsa052000.75070554
109Sphingolipid metabolism_Homo sapiens_hsa006000.73506353
110ECM-receptor interaction_Homo sapiens_hsa045120.73162814
111Oxytocin signaling pathway_Homo sapiens_hsa049210.70844516
112Glucagon signaling pathway_Homo sapiens_hsa049220.70110236
113Circadian entrainment_Homo sapiens_hsa047130.70025350
114Fatty acid metabolism_Homo sapiens_hsa012120.69113468
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67612662
116Linoleic acid metabolism_Homo sapiens_hsa005910.67246221
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66810701
118Ovarian steroidogenesis_Homo sapiens_hsa049130.65668136
119Starch and sucrose metabolism_Homo sapiens_hsa005000.65232870
120Taste transduction_Homo sapiens_hsa047420.64643634
121Legionellosis_Homo sapiens_hsa051340.64479307
122Metabolic pathways_Homo sapiens_hsa011000.63632561
123Influenza A_Homo sapiens_hsa051640.63387038
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.58974119
125Graft-versus-host disease_Homo sapiens_hsa053320.58861843
126Wnt signaling pathway_Homo sapiens_hsa043100.58689272
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.58637268
128Insulin secretion_Homo sapiens_hsa049110.57441002
129Dorso-ventral axis formation_Homo sapiens_hsa043200.57162487
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56021677
131Pyruvate metabolism_Homo sapiens_hsa006200.52660408
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51401208
133Nicotine addiction_Homo sapiens_hsa050330.51151844
134Toxoplasmosis_Homo sapiens_hsa051450.50966002
135Bladder cancer_Homo sapiens_hsa052190.50257703
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50002671
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.49072699
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48982977
139Melanoma_Homo sapiens_hsa052180.48942438
140Prostate cancer_Homo sapiens_hsa052150.48271977
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47821862
142Autoimmune thyroid disease_Homo sapiens_hsa053200.46990897
143Vitamin B6 metabolism_Homo sapiens_hsa007500.46861764
144Fatty acid biosynthesis_Homo sapiens_hsa000610.46195363
145Staphylococcus aureus infection_Homo sapiens_hsa051500.45725293
146Tight junction_Homo sapiens_hsa045300.45340777
147Morphine addiction_Homo sapiens_hsa050320.43734846
148Renin secretion_Homo sapiens_hsa049240.42986735
149Long-term depression_Homo sapiens_hsa047300.41779622
150Hepatitis B_Homo sapiens_hsa051610.41748723
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40840988
152Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40565592
153Gastric acid secretion_Homo sapiens_hsa049710.39989936
154Primary immunodeficiency_Homo sapiens_hsa053400.39360630
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39239776
156Alcoholism_Homo sapiens_hsa050340.39094742
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38937119
158Colorectal cancer_Homo sapiens_hsa052100.38813211
159Intestinal immune network for IgA production_Homo sapiens_hsa046720.38266519
160Malaria_Homo sapiens_hsa051440.37597588
161Leishmaniasis_Homo sapiens_hsa051400.36938239
162Tyrosine metabolism_Homo sapiens_hsa003500.35794182
163Mineral absorption_Homo sapiens_hsa049780.35156603
164Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34963954
165Oocyte meiosis_Homo sapiens_hsa041140.33012389
166Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32643616
167Thyroid cancer_Homo sapiens_hsa052160.31391325
168TNF signaling pathway_Homo sapiens_hsa046680.30376363
169Glutathione metabolism_Homo sapiens_hsa004800.30109792
170Proteoglycans in cancer_Homo sapiens_hsa052050.29844282
171Acute myeloid leukemia_Homo sapiens_hsa052210.29393078
172Allograft rejection_Homo sapiens_hsa053300.28176915
173Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27950876
174Asthma_Homo sapiens_hsa053100.27882951
175Leukocyte transendothelial migration_Homo sapiens_hsa046700.25524306
176Hepatitis C_Homo sapiens_hsa051600.24745634
177Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23612441
178Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23202514
179Glycosaminoglycan degradation_Homo sapiens_hsa005310.21495013
180Inositol phosphate metabolism_Homo sapiens_hsa005620.20114130
181Tuberculosis_Homo sapiens_hsa051520.19878353

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