DENND2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.73173689
2nucleobase catabolic process (GO:0046113)3.83411150
3limb bud formation (GO:0060174)3.83160243
4paraxial mesoderm development (GO:0048339)3.77956848
5behavioral response to nicotine (GO:0035095)3.62973081
6ionotropic glutamate receptor signaling pathway (GO:0035235)3.55240372
7regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49369198
8lateral sprouting from an epithelium (GO:0060601)3.45075477
9regulation of timing of cell differentiation (GO:0048505)3.42478229
10central nervous system myelination (GO:0022010)3.40902085
11axon ensheathment in central nervous system (GO:0032291)3.40902085
12dendritic spine morphogenesis (GO:0060997)3.37783815
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28347504
14regulation of development, heterochronic (GO:0040034)3.24775524
15DNA integration (GO:0015074)3.19572018
16regulation of axon extension involved in axon guidance (GO:0048841)3.17836660
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15750342
18nonmotile primary cilium assembly (GO:0035058)3.12497771
19spinal cord development (GO:0021510)3.11926693
20regulation of axon guidance (GO:1902667)3.11147553
21vocalization behavior (GO:0071625)3.08146977
22regulation of respiratory system process (GO:0044065)3.07590183
23transmission of nerve impulse (GO:0019226)3.07361461
24auditory behavior (GO:0031223)3.04064799
25protein localization to synapse (GO:0035418)3.02299288
26synaptic transmission, glutamatergic (GO:0035249)3.02030085
27sympathetic nervous system development (GO:0048485)3.00285639
28neuronal action potential propagation (GO:0019227)2.96393770
29appendage development (GO:0048736)2.96102176
30limb development (GO:0060173)2.96102176
31glutamate receptor signaling pathway (GO:0007215)2.95312325
32cell proliferation in forebrain (GO:0021846)2.94206853
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92762116
34ganglion development (GO:0061548)2.90785592
35dendrite morphogenesis (GO:0048813)2.88507950
36regulation of somitogenesis (GO:0014807)2.88262203
37regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84798547
38neuron cell-cell adhesion (GO:0007158)2.82323547
39retinal ganglion cell axon guidance (GO:0031290)2.81961831
40microtubule depolymerization (GO:0007019)2.81388345
41synapse assembly (GO:0007416)2.80780151
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79926420
43cerebral cortex radially oriented cell migration (GO:0021799)2.79662579
44face development (GO:0060324)2.77300663
45collecting duct development (GO:0072044)2.74809633
46protein heterotrimerization (GO:0070208)2.74153452
47negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72068459
48regulation of nuclear cell cycle DNA replication (GO:0033262)2.71853067
49cranial nerve morphogenesis (GO:0021602)2.69037083
50establishment of mitochondrion localization (GO:0051654)2.66757591
51kinetochore assembly (GO:0051382)2.63987301
52dermatan sulfate biosynthetic process (GO:0030208)2.62605344
53negative regulation of axon guidance (GO:1902668)2.62067829
54nephron tubule development (GO:0072080)2.61971025
55DNA damage response, detection of DNA damage (GO:0042769)2.61912633
56central nervous system neuron axonogenesis (GO:0021955)2.60002247
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.58700917
58spinal cord motor neuron differentiation (GO:0021522)2.58415729
59neurotransmitter-gated ion channel clustering (GO:0072578)2.58215530
60cranial nerve structural organization (GO:0021604)2.57371494
61head development (GO:0060322)2.57363163
62neuromuscular synaptic transmission (GO:0007274)2.57107492
63regulation of glutamate receptor signaling pathway (GO:1900449)2.56683009
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56566152
65cell differentiation in spinal cord (GO:0021515)2.56127185
66kidney morphogenesis (GO:0060993)2.56060348
67cell fate commitment involved in formation of primary germ layer (GO:0060795)2.55567401
68detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55328442
69camera-type eye morphogenesis (GO:0048593)2.55198386
70regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54321967
71negative regulation of myoblast differentiation (GO:0045662)2.53904055
72startle response (GO:0001964)2.53770290
73neuronal ion channel clustering (GO:0045161)2.53485862
74spinal cord association neuron differentiation (GO:0021527)2.52317669
75regulation of synapse structural plasticity (GO:0051823)2.50057582
76centriole assembly (GO:0098534)2.47419333
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.46078876
78neuron-neuron synaptic transmission (GO:0007270)2.45543877
79facial nerve structural organization (GO:0021612)2.45441719
80neuronal stem cell maintenance (GO:0097150)2.45174566
81axon extension (GO:0048675)2.43877806
82presynaptic membrane assembly (GO:0097105)2.43427327
83mesenchymal cell differentiation involved in kidney development (GO:0072161)2.43275839
84mesenchymal cell differentiation involved in renal system development (GO:2001012)2.43275839
85mechanosensory behavior (GO:0007638)2.43273844
86membrane depolarization during action potential (GO:0086010)2.42358225
87mesonephros development (GO:0001823)2.41840837
88synapse organization (GO:0050808)2.41783486
89response to auditory stimulus (GO:0010996)2.41212018
90mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.40575446
91postsynaptic membrane organization (GO:0001941)2.40250250
92presynaptic membrane organization (GO:0097090)2.40169072
93forebrain neuron differentiation (GO:0021879)2.39709753
94positive regulation of synapse assembly (GO:0051965)2.38914577
95neuron remodeling (GO:0016322)2.38755673
96regulation of respiratory gaseous exchange (GO:0043576)2.38349987
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.38311389
98histone H2B ubiquitination (GO:0033523)2.38118943
99mRNA splice site selection (GO:0006376)2.38013202
100homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.37551004
101gamma-aminobutyric acid transport (GO:0015812)2.37178048
102midbrain development (GO:0030901)2.37122370
103renal tubule development (GO:0061326)2.36190372
104developmental pigmentation (GO:0048066)2.36182936
105synaptic vesicle maturation (GO:0016188)2.35909329
106astrocyte differentiation (GO:0048708)2.33704819
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.32609198
108negative regulation of protein localization to cell surface (GO:2000009)2.32549706
109embryonic camera-type eye development (GO:0031076)2.32488583
110membrane assembly (GO:0071709)2.31621696
111metanephric mesenchyme development (GO:0072075)2.31619702
112female gonad development (GO:0008585)2.31049339
113establishment of planar polarity (GO:0001736)2.30608854
114establishment of tissue polarity (GO:0007164)2.30608854
115somite development (GO:0061053)2.30330065
116keratinocyte development (GO:0003334)2.30259450
117suckling behavior (GO:0001967)2.30205822
118calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29568414
119kidney mesenchyme development (GO:0072074)2.29167635
120axonal fasciculation (GO:0007413)2.28312307
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28270072
122dermatan sulfate metabolic process (GO:0030205)2.28043201
123notochord development (GO:0030903)2.27034485
124adult walking behavior (GO:0007628)2.26875598
125inner ear receptor stereocilium organization (GO:0060122)2.25340878
126regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23803658
127retina layer formation (GO:0010842)2.23784277
128forelimb morphogenesis (GO:0035136)2.22978853
129regulation of action potential (GO:0098900)2.22810811
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.22476453
131DNA ligation (GO:0006266)2.22450818
132cochlea morphogenesis (GO:0090103)2.22432525
133negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.22332480
134outer ear morphogenesis (GO:0042473)2.22085668
135detection of mechanical stimulus involved in sensory perception (GO:0050974)2.21394158
136urogenital system development (GO:0001655)2.20687819
137cell differentiation involved in metanephros development (GO:0072202)2.20558513
138locomotory exploration behavior (GO:0035641)2.20424840
139histone H3-K4 trimethylation (GO:0080182)2.20130017
140exploration behavior (GO:0035640)2.19596068
141enteric nervous system development (GO:0048484)2.19206599
142neuron recognition (GO:0008038)2.19185289
143long-chain fatty acid biosynthetic process (GO:0042759)2.18461212
144cranial nerve development (GO:0021545)2.18019511
145neuron maturation (GO:0042551)2.17885707
146lens fiber cell development (GO:0070307)2.17788128
147central nervous system projection neuron axonogenesis (GO:0021952)2.17518233
148mesenchymal to epithelial transition (GO:0060231)2.17201284
149photoreceptor cell differentiation (GO:0046530)2.17199524
150eye photoreceptor cell differentiation (GO:0001754)2.17199524
151neural crest cell development (GO:0014032)2.16551307
152extracellular negative regulation of signal transduction (GO:1900116)2.16046924
153extracellular regulation of signal transduction (GO:1900115)2.16046924
154DNA strand renaturation (GO:0000733)2.15798403
155bone trabecula formation (GO:0060346)2.14938286
156eyelid development in camera-type eye (GO:0061029)2.14778582
157kinetochore organization (GO:0051383)2.14745826
158lung-associated mesenchyme development (GO:0060484)2.14325987
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.13849891
160epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.13817055
161righting reflex (GO:0060013)2.12960567
162cell migration in hindbrain (GO:0021535)2.12603770
163centriole replication (GO:0007099)2.12491895
164regulation of smoothened signaling pathway (GO:0008589)2.12343712
165histone H4-K12 acetylation (GO:0043983)2.11618910
166regulation of NIK/NF-kappaB signaling (GO:1901222)2.11552730
167glomerulus development (GO:0032835)2.10512840
168forebrain neuron development (GO:0021884)2.10199544
169olfactory bulb development (GO:0021772)2.10114117
170negative regulation of stem cell proliferation (GO:2000647)2.08809013
171embryonic digit morphogenesis (GO:0042733)2.08786300
172embryonic forelimb morphogenesis (GO:0035115)2.08273756
173positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.08216168
174regulation of synapse assembly (GO:0051963)2.08122430
175cornea development in camera-type eye (GO:0061303)2.07337287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45845834
2GBX2_23144817_ChIP-Seq_PC3_Human3.26965320
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.76094972
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69983619
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64943056
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.62926416
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.61753028
8CBX2_27304074_Chip-Seq_ESCs_Mouse2.52674848
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48144554
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.32202108
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22811271
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21498755
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19949099
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19949099
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19579611
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.18598804
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17365916
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16250792
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14441027
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14426069
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11876678
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.05457162
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04382766
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.99863460
25RNF2_27304074_Chip-Seq_NSC_Mouse1.99056135
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90662875
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87620282
28ZNF274_21170338_ChIP-Seq_K562_Hela1.87523994
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84696357
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.78556706
31* REST_21632747_ChIP-Seq_MESCs_Mouse1.77134743
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75528917
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73342923
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72363702
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70748711
36* TAF15_26573619_Chip-Seq_HEK293_Human1.64292296
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61079717
38FUS_26573619_Chip-Seq_HEK293_Human1.60746210
39DROSHA_22980978_ChIP-Seq_HELA_Human1.59380855
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.58090368
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55115936
42IGF1R_20145208_ChIP-Seq_DFB_Human1.50552295
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46876944
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46542973
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.45321661
46AR_21572438_ChIP-Seq_LNCaP_Human1.45241351
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.44972754
48VDR_22108803_ChIP-Seq_LS180_Human1.44730009
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44435995
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43963909
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.43410421
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42468576
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40823588
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.40663227
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40596264
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40367509
57P300_19829295_ChIP-Seq_ESCs_Human1.39422354
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.38747794
59EWS_26573619_Chip-Seq_HEK293_Human1.38073927
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38042296
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.35462081
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34328484
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34176995
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.33470984
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33393756
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.32633173
67* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30565777
68* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30565777
69* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30565777
70TP53_16413492_ChIP-PET_HCT116_Human1.30047484
71* STAT3_23295773_ChIP-Seq_U87_Human1.29618176
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26090561
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25669315
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.24624103
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24508936
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24070622
77* REST_18959480_ChIP-ChIP_MESCs_Mouse1.22733798
78EP300_21415370_ChIP-Seq_HL-1_Mouse1.21238101
79* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21066061
80* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21066061
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20831208
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.20706233
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.20139609
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.19870780
85P53_22387025_ChIP-Seq_ESCs_Mouse1.19336699
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19245025
87AR_25329375_ChIP-Seq_VCAP_Human1.18967695
88P300_18555785_Chip-Seq_ESCs_Mouse1.18388903
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16930534
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.16492021
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15113188
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.14972463
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.14667649
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14050319
95SMAD4_21799915_ChIP-Seq_A2780_Human1.13351643
96TCF4_23295773_ChIP-Seq_U87_Human1.13233270
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11477724
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11460335
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.10781098
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10638939
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10570580
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10360928
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10011014
104BCAT_22108803_ChIP-Seq_LS180_Human1.08930652
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08896187
106TP53_18474530_ChIP-ChIP_U2OS_Human1.08638002
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08197531
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.07440485
109CBP_20019798_ChIP-Seq_JUKART_Human1.06774309
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06774309
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06657003
112SMAD4_21741376_ChIP-Seq_HESCs_Human1.06641906
113ER_23166858_ChIP-Seq_MCF-7_Human1.05645715
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.05426927
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04965215
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.04815913
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03077858
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03033424
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03012327
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01761705
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.01516338
122ZFX_18555785_Chip-Seq_ESCs_Mouse1.00966499
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00898790
124RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99994712
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99763045
126* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99258103
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98844900
128RUNX2_22187159_ChIP-Seq_PCA_Human0.98102580
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97538840
130ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96989574
131STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96894029
132TAL1_26923725_Chip-Seq_HPCs_Mouse0.96711000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.41858794
2MP0000566_synostosis3.29729704
3MP0003136_yellow_coat_color3.13232745
4MP0003941_abnormal_skin_development2.74254005
5MP0001188_hyperpigmentation2.74243761
6MP0006292_abnormal_olfactory_placode2.68689597
7MP0005171_absent_coat_pigmentation2.49530847
8MP0004885_abnormal_endolymph2.28679742
9MP0002102_abnormal_ear_morphology2.10656501
10MP0002736_abnormal_nociception_after2.10552574
11MP0000049_abnormal_middle_ear2.08031953
12MP0003635_abnormal_synaptic_transmissio2.06869347
13MP0004270_analgesia2.06782661
14MP0001968_abnormal_touch/_nociception2.04876144
15MP0002735_abnormal_chemical_nociception2.00684131
16MP0002249_abnormal_larynx_morphology1.97000497
17MP0003938_abnormal_ear_development1.93708952
18MP0000778_abnormal_nervous_system1.92240615
19MP0002938_white_spotting1.88159013
20MP0005623_abnormal_meninges_morphology1.82996900
21MP0003385_abnormal_body_wall1.81672953
22MP0001984_abnormal_olfaction1.81450256
23MP0003880_abnormal_central_pattern1.77484062
24MP0002063_abnormal_learning/memory/cond1.75133392
25MP0002734_abnormal_mechanical_nocicepti1.74461587
26MP0009250_abnormal_appendicular_skeleto1.74055363
27MP0010030_abnormal_orbit_morphology1.72942337
28MP0005409_darkened_coat_color1.72764864
29MP0003937_abnormal_limbs/digits/tail_de1.72180340
30MP0004381_abnormal_hair_follicle1.70235940
31MP0002572_abnormal_emotion/affect_behav1.66894494
32MP0009745_abnormal_behavioral_response1.66132478
33MP0003787_abnormal_imprinting1.64180913
34MP0003122_maternal_imprinting1.63802050
35MP0003755_abnormal_palate_morphology1.63761639
36MP0000762_abnormal_tongue_morphology1.60304105
37MP0002272_abnormal_nervous_system1.58559006
38MP0000026_abnormal_inner_ear1.52246427
39MP0002909_abnormal_adrenal_gland1.51847602
40MP0005257_abnormal_intraocular_pressure1.49790660
41MP0003121_genomic_imprinting1.48366854
42MP0002233_abnormal_nose_morphology1.44347290
43MP0004742_abnormal_vestibular_system1.43861627
44MP0002064_seizures1.43477904
45MP0000569_abnormal_digit_pigmentation1.41609437
46MP0001970_abnormal_pain_threshold1.41109027
47MP0004133_heterotaxia1.39939036
48MP0002277_abnormal_respiratory_mucosa1.39718125
49MP0008789_abnormal_olfactory_epithelium1.39047469
50MP0005423_abnormal_somatic_nervous1.38003403
51MP0002751_abnormal_autonomic_nervous1.37988975
52MP0001486_abnormal_startle_reflex1.36176661
53MP0002116_abnormal_craniofacial_bone1.33553928
54MP0002234_abnormal_pharynx_morphology1.32070810
55MP0002163_abnormal_gland_morphology1.30567939
56MP0001502_abnormal_circadian_rhythm1.30328094
57MP0000462_abnormal_digestive_system1.27332746
58MP0001286_abnormal_eye_development1.26866926
59MP0009046_muscle_twitch1.26636123
60MP0001299_abnormal_eye_distance/1.26406679
61MP0004142_abnormal_muscle_tone1.25548159
62MP0005551_abnormal_eye_electrophysiolog1.24363047
63MP0003942_abnormal_urinary_system1.23946700
64MP0002733_abnormal_thermal_nociception1.23813353
65MP0002067_abnormal_sensory_capabilities1.22484241
66MP0004134_abnormal_chest_morphology1.16991606
67MP0008057_abnormal_DNA_replication1.16797900
68MP0001958_emphysema1.15952444
69MP0002752_abnormal_somatic_nervous1.15728776
70MP0002152_abnormal_brain_morphology1.15553501
71MP0000383_abnormal_hair_follicle1.15349690
72MP0005394_taste/olfaction_phenotype1.14974147
73MP0005499_abnormal_olfactory_system1.14974147
74MP0000432_abnormal_head_morphology1.14631172
75MP0002184_abnormal_innervation1.14555155
76MP0003315_abnormal_perineum_morphology1.12033398
77MP0005503_abnormal_tendon_morphology1.11883795
78MP0006276_abnormal_autonomic_nervous1.11831305
79MP0001905_abnormal_dopamine_level1.11619382
80MP0003861_abnormal_nervous_system1.11189759
81MP0000631_abnormal_neuroendocrine_gland1.10890279
82MP0006072_abnormal_retinal_apoptosis1.10794795
83MP0002177_abnormal_outer_ear1.09473200
84MP0003935_abnormal_craniofacial_develop1.07556480
85MP0005386_behavior/neurological_phenoty1.06508623
86MP0004924_abnormal_behavior1.06508623
87MP0005508_abnormal_skeleton_morphology1.06134530
88MP0001963_abnormal_hearing_physiology1.05853666
89MP0004811_abnormal_neuron_physiology1.05789919
90MP0004272_abnormal_basement_membrane1.04966058
91MP0000015_abnormal_ear_pigmentation1.04268789
92MP0005379_endocrine/exocrine_gland_phen1.03719683
93MP0002932_abnormal_joint_morphology1.03283590
94MP0008058_abnormal_DNA_repair1.02693826
95MP0010368_abnormal_lymphatic_system1.01291271
96MP0005377_hearing/vestibular/ear_phenot0.99855955
97MP0003878_abnormal_ear_physiology0.99855955
98MP0003950_abnormal_plasma_membrane0.99479479
99MP0001879_abnormal_lymphatic_vessel0.99326333
100MP0002114_abnormal_axial_skeleton0.99150254
101MP0005174_abnormal_tail_pigmentation0.99122394
102MP0000534_abnormal_ureter_morphology0.98762887
103MP0001485_abnormal_pinna_reflex0.98262894
104MP0001293_anophthalmia0.98078943
105MP0010386_abnormal_urinary_bladder0.97838160
106MP0009379_abnormal_foot_pigmentation0.97553561
107MP0002822_catalepsy0.97111391
108MP0005645_abnormal_hypothalamus_physiol0.96001056
109MP0003119_abnormal_digestive_system0.95371274
110MP0005187_abnormal_penis_morphology0.94289472
111MP0005646_abnormal_pituitary_gland0.92790542
112MP0008995_early_reproductive_senescence0.92786055
113MP0000647_abnormal_sebaceous_gland0.92465410
114MP0001501_abnormal_sleep_pattern0.91990663
115MP0008877_abnormal_DNA_methylation0.91255350
116MP0003283_abnormal_digestive_organ0.91115522
117MP0002111_abnormal_tail_morphology0.90996262
118MP0008932_abnormal_embryonic_tissue0.90943687
119MP0005253_abnormal_eye_physiology0.88435532
120MP0001529_abnormal_vocalization0.88349511
121MP0002697_abnormal_eye_size0.88299912
122MP0002653_abnormal_ependyma_morphology0.88226157
123MP0001346_abnormal_lacrimal_gland0.87576316
124MP0005195_abnormal_posterior_eye0.87529438
125MP0004145_abnormal_muscle_electrophysio0.86843542
126MP0002066_abnormal_motor_capabilities/c0.86827992
127MP0000613_abnormal_salivary_gland0.86073698
128MP0005248_abnormal_Harderian_gland0.84955645
129MP0002109_abnormal_limb_morphology0.84585138
130MP0005391_vision/eye_phenotype0.84295447
131MP0000955_abnormal_spinal_cord0.84141225
132MP0002108_abnormal_muscle_morphology0.83792345
133MP0000428_abnormal_craniofacial_morphol0.83550525
134MP0002882_abnormal_neuron_morphology0.81218602
135MP0000537_abnormal_urethra_morphology0.80796080
136MP0003111_abnormal_nucleus_morphology0.80216658
137MP0005595_abnormal_vascular_smooth0.80168887
138MP0001440_abnormal_grooming_behavior0.79964574
139MP0002876_abnormal_thyroid_physiology0.79801756
140MP0002557_abnormal_social/conspecific_i0.79615594
141MP0003890_abnormal_embryonic-extraembry0.79368980
142MP0002638_abnormal_pupillary_reflex0.78317116
143MP0002081_perinatal_lethality0.77398058
144MP0008438_abnormal_cutaneous_collagen0.77270802

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33729474
2Duplicated collecting system (HP:0000081)3.81850947
3Chromsome breakage (HP:0040012)3.76917284
4Septo-optic dysplasia (HP:0100842)3.60925674
5Abnormality of the renal collecting system (HP:0004742)3.50675105
6Neonatal short-limb short stature (HP:0008921)3.38085472
7Focal seizures (HP:0007359)2.94958731
8Genetic anticipation (HP:0003743)2.78101791
9Soft skin (HP:0000977)2.72522646
10Hyperventilation (HP:0002883)2.68423224
11Focal motor seizures (HP:0011153)2.68170150
12Upper limb muscle weakness (HP:0003484)2.62748294
13Hemiparesis (HP:0001269)2.62263211
14Abnormality of the ischium (HP:0003174)2.57062479
15Molar tooth sign on MRI (HP:0002419)2.49642541
16Abnormality of midbrain morphology (HP:0002418)2.49642541
17Absent septum pellucidum (HP:0001331)2.48526482
18Duplication of thumb phalanx (HP:0009942)2.44220876
19Drooling (HP:0002307)2.41220960
20Aplasia cutis congenita (HP:0001057)2.39308407
21Pancreatic fibrosis (HP:0100732)2.36588377
22Megalencephaly (HP:0001355)2.36367254
23Abnormality of the renal medulla (HP:0100957)2.36255352
24Bladder diverticulum (HP:0000015)2.35514080
25Anophthalmia (HP:0000528)2.35463994
26Vascular tortuosity (HP:0004948)2.35190969
27True hermaphroditism (HP:0010459)2.34627195
28Wide anterior fontanel (HP:0000260)2.33905254
29Optic nerve hypoplasia (HP:0000609)2.32610739
30Abnormality of the septum pellucidum (HP:0007375)2.30823652
31Concave nail (HP:0001598)2.30148130
32Limb dystonia (HP:0002451)2.26767103
33Stomach cancer (HP:0012126)2.26508004
34Supernumerary ribs (HP:0005815)2.25765973
35Supernumerary bones of the axial skeleton (HP:0009144)2.25411363
36Prostate neoplasm (HP:0100787)2.24916069
37Ectopic kidney (HP:0000086)2.24847329
38Pancreatic cysts (HP:0001737)2.23432604
39Intestinal atresia (HP:0011100)2.20921776
40Meckel diverticulum (HP:0002245)2.19975416
41Absent radius (HP:0003974)2.18041676
42Atonic seizures (HP:0010819)2.17116893
43Absent forearm bone (HP:0003953)2.16601871
44Aplasia involving forearm bones (HP:0009822)2.16601871
45Atelectasis (HP:0100750)2.15838712
46Chin dimple (HP:0010751)2.14809292
47Abnormality of the ileum (HP:0001549)2.14721680
48Nephroblastoma (Wilms tumor) (HP:0002667)2.13858640
49Morphological abnormality of the middle ear (HP:0008609)2.13448602
50Abnormality of incisor morphology (HP:0011063)2.12569671
51Hypoplastic ischia (HP:0003175)2.12359353
52Excessive salivation (HP:0003781)2.09578854
53Myelomeningocele (HP:0002475)2.09488716
54Abnormality of the parietal bone (HP:0002696)2.09438818
55Arterial tortuosity (HP:0005116)2.07597746
56Cutaneous finger syndactyly (HP:0010554)2.07376432
57Embryonal renal neoplasm (HP:0011794)2.06933998
58Infantile muscular hypotonia (HP:0008947)2.05875951
59Abnormality of dentin (HP:0010299)2.05029808
60Midline defect of the nose (HP:0004122)2.04383036
61Abnormality of the nasolacrimal system (HP:0000614)2.03571546
62Vitreoretinal degeneration (HP:0000655)2.03421988
63Bowel diverticulosis (HP:0005222)2.02780621
64Pachygyria (HP:0001302)2.01910218
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00717779
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00403411
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.00247510
68Broad-based gait (HP:0002136)1.99924039
69Supernumerary spleens (HP:0009799)1.99422298
70Action tremor (HP:0002345)1.99325391
71Abnormality of the lacrimal duct (HP:0011481)1.98602913
72Conical tooth (HP:0000698)1.97831404
73Absent speech (HP:0001344)1.96220467
74Turricephaly (HP:0000262)1.95496703
75Pulmonary artery stenosis (HP:0004415)1.94371803
76Overfolded helix (HP:0000396)1.94312812
77Parakeratosis (HP:0001036)1.93372332
78Nasolacrimal duct obstruction (HP:0000579)1.93196542
79Abnormality of the incisor (HP:0000676)1.92950985
80Abnormal ciliary motility (HP:0012262)1.92315392
81Broad metatarsal (HP:0001783)1.90450965
82Abnormality of the preputium (HP:0100587)1.87063474
83Osteomalacia (HP:0002749)1.87049916
84Type II lissencephaly (HP:0007260)1.86920096
85Coronal craniosynostosis (HP:0004440)1.86903005
86Gait imbalance (HP:0002141)1.86476649
87Cupped ear (HP:0000378)1.85907356
88Protrusio acetabuli (HP:0003179)1.84399718
89Abnormality of the diencephalon (HP:0010662)1.84300505
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84223357
91Short 4th metacarpal (HP:0010044)1.84223357
92Cutaneous syndactyly (HP:0012725)1.84194290
93Mild short stature (HP:0003502)1.83481210
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.83255996
95Absent/shortened dynein arms (HP:0200106)1.83255996
96Abnormal number of incisors (HP:0011064)1.82673147
97Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82663140
98Renovascular hypertension (HP:0100817)1.82553006
99Medial flaring of the eyebrow (HP:0010747)1.82370589
100Cystic liver disease (HP:0006706)1.82086596
101White forelock (HP:0002211)1.81161889
102Anterior segment dysgenesis (HP:0007700)1.81108598
103Broad long bones (HP:0005622)1.80437611
104Polyphagia (HP:0002591)1.79929151
105Shawl scrotum (HP:0000049)1.79908258
106Adrenal hypoplasia (HP:0000835)1.79656995
107Exotropia (HP:0000577)1.77617495
108Triphalangeal thumb (HP:0001199)1.77510757
109Congenital sensorineural hearing impairment (HP:0008527)1.77132498
110Hypoventilation (HP:0002791)1.77105080
111Protruding tongue (HP:0010808)1.75667738
112Generalized tonic-clonic seizures (HP:0002069)1.75553965
113Renal agenesis (HP:0000104)1.75407896
114Abnormal respiratory motile cilium morphology (HP:0005938)1.75280813
115Abnormal respiratory epithelium morphology (HP:0012253)1.75280813
116Sex reversal (HP:0012245)1.75178591
117Abnormal sex determination (HP:0012244)1.75178591
118Progressive cerebellar ataxia (HP:0002073)1.74672498
119Tubular atrophy (HP:0000092)1.73809033
120Abnormality of the nasal septum (HP:0000419)1.72770249
121Chorioretinal atrophy (HP:0000533)1.72669161
122Genu recurvatum (HP:0002816)1.72168786
123Aqueductal stenosis (HP:0002410)1.72094657
124Agitation (HP:0000713)1.71549953
125Atrophic scars (HP:0001075)1.70990776
126Delayed gross motor development (HP:0002194)1.70936558
127Short thumb (HP:0009778)1.70439435
128Chronic hepatic failure (HP:0100626)1.70102475
129Preaxial hand polydactyly (HP:0001177)1.70039353
130Genital tract atresia (HP:0001827)1.69074332
131Oligodactyly (hands) (HP:0001180)1.69043603
132Vaginal atresia (HP:0000148)1.68638730
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.67957427
134Myokymia (HP:0002411)1.67586250
135Increased corneal curvature (HP:0100692)1.67004480
136Keratoconus (HP:0000563)1.67004480
137Prolonged QT interval (HP:0001657)1.66839273
138Abnormally folded helix (HP:0008544)1.65699268
139Aplasia of the musculature (HP:0100854)1.65607023
140Febrile seizures (HP:0002373)1.65141303
141Patellar dislocation (HP:0002999)1.64471443
142Bronchomalacia (HP:0002780)1.64304486
143Ectopic anus (HP:0004397)1.64062510
144Rib fusion (HP:0000902)1.63919982
145Gaze-evoked nystagmus (HP:0000640)1.63644102
146Postaxial hand polydactyly (HP:0001162)1.63424627
147Preaxial foot polydactyly (HP:0001841)1.63049702
148Premature rupture of membranes (HP:0001788)1.62944644
149Congenital stationary night blindness (HP:0007642)1.62663838
150Epileptic encephalopathy (HP:0200134)1.61413826
151Patchy hypopigmentation of hair (HP:0011365)1.61119808
152Amblyopia (HP:0000646)1.60923915
153Megalocornea (HP:0000485)1.60363542
154Flat cornea (HP:0007720)1.59903034
155Abnormality of the 4th metacarpal (HP:0010012)1.59838612
156Breast hypoplasia (HP:0003187)1.59297331
157Anomalous pulmonary venous return (HP:0010772)1.59275532
158Symphalangism affecting the phalanges of the hand (HP:0009773)1.59170365
159Highly arched eyebrow (HP:0002553)1.59063363
160Abnormality of the pulmonary veins (HP:0011718)1.59000680
161Anencephaly (HP:0002323)1.58819816
162Vertebral arch anomaly (HP:0008438)1.58370487
163Ulnar claw (HP:0001178)1.58329722
164Hyperextensible skin (HP:0000974)1.57428852
165Gastrointestinal atresia (HP:0002589)1.57354043
166Lissencephaly (HP:0001339)1.57321703
167Abnormality of the antihelix (HP:0009738)1.56898955
168Bulbous nose (HP:0000414)1.56547638
169Esophageal atresia (HP:0002032)1.56520955
170Increased number of teeth (HP:0011069)1.56342708
171Abnormality of the carotid arteries (HP:0005344)1.54817402
172Renal hypoplasia (HP:0000089)1.54774588
173Abnormal respiratory motile cilium physiology (HP:0012261)1.54469090
174Maternal diabetes (HP:0009800)1.52440298
175Renal dysplasia (HP:0000110)1.49975899
176Nephronophthisis (HP:0000090)1.49815771
177Rectovaginal fistula (HP:0000143)1.48467583
178Rectal fistula (HP:0100590)1.48467583
179Abnormality of the labia minora (HP:0012880)1.48180609
180Patellar aplasia (HP:0006443)1.47997989
181Bell-shaped thorax (HP:0001591)1.47873015
182Vesicoureteral reflux (HP:0000076)1.47576053
183Abnormality of the phalanges of the hallux (HP:0010057)1.47245082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.24601602
2ZAK3.05256300
3NTRK12.90622570
4FRK2.88955238
5IRAK22.71404356
6IRAK32.66116528
7MARK12.63332073
8TNIK2.47006415
9MKNK22.46758264
10STK162.44642529
11PLK42.40477062
12IRAK12.00585192
13MKNK11.98265416
14BRD41.89567482
15BMPR1B1.87058025
16EPHB21.83839464
17CAMK1G1.80592141
18PAK61.78390865
19IRAK41.76082936
20MAP3K41.75500241
21PINK11.73978642
22EIF2AK21.55238700
23NEK61.53149297
24PNCK1.52039645
25LATS11.51050261
26CAMK1D1.49481135
27CLK11.49243881
28SRPK11.47468286
29DYRK21.45038570
30CDK31.43589455
31GRK11.38178499
32PHKG21.38077296
33PHKG11.38077296
34YES11.37083670
35WNK41.36597611
36MAPK131.34408137
37PKN11.32269134
38PAK31.32240054
39ICK1.29756227
40STK391.29334697
41PRKCG1.28226680
42MUSK1.27542799
43ADRBK21.22157094
44STK38L1.20632461
45MAP4K21.20606139
46TYRO31.20175559
47FGFR21.20139094
48TTK1.19741804
49BCR1.19665294
50CSNK1A1L1.18626642
51NUAK11.17473319
52PRPF4B1.10917420
53AKT31.08944047
54MOS1.05912714
55BMPR21.04891681
56PRKD31.03461124
57DDR21.01970328
58FGR1.00631765
59NTRK30.99822184
60MAP2K70.96528477
61NEK20.94236203
62NTRK20.92350522
63ADRBK10.91213655
64PLK20.89910782
65GRK70.89116191
66CHEK20.88083366
67CDK50.87848685
68CSNK1G30.86675891
69PBK0.86174970
70SGK2230.80881945
71SGK4940.80881945
72EPHA30.80627226
73MAPK150.80466123
74TLK10.79999813
75MINK10.79043920
76CDK70.77963983
77CSNK1G10.77396130
78EPHA20.76856911
79SGK20.76845470
80ERBB30.76606329
81PAK20.76371512
82PDGFRA0.75984992
83PRKD20.74495244
84PLK30.73520597
85DAPK20.71886577
86PRKCE0.71695324
87CDC42BPA0.71305740
88VRK10.71242048
89CAMK10.71127137
90UHMK10.69860682
91DYRK30.67796642
92PRKCH0.66910180
93LATS20.66171437
94CAMK2B0.64686559
95BLK0.63871225
96ERBB40.63492930
97DYRK1A0.62328091
98GRK50.61080821
99KSR10.60050509
100PLK10.59512683
101EPHA40.59026671
102ROCK20.58972583
103ATR0.58729646
104CAMK2D0.58213872
105PDGFRB0.57573993
106STK110.57366744
107CDK120.55286584
108CAMK2A0.54639293
109PRKCZ0.54549799
110OXSR10.54090633
111SIK20.53889525
112BUB10.53685168
113TIE10.53398954
114TRIM280.51522899
115ATM0.50338425
116CAMKK10.49107142
117PTK2B0.48748361
118FER0.48526333
119ERBB20.48308893
120INSRR0.48025368
121CAMK2G0.47511725
122PRKAA10.45428364
123CSNK1G20.43068208
124CDK10.42727674
125MAP3K60.42646487
126WNK10.41645538
127PIK3CA0.40969091
128CHEK10.40054952
129CDK180.39791584
130NME10.39347740
131RPS6KA50.39319832
132PRKCI0.39309236
133CSNK1D0.38838531
134CDK150.38181041
135WNK30.37962476
136MET0.37228185
137PRKG10.37208186
138CSNK1E0.37204109
139SGK10.37131815
140ROCK10.37048257
141LIMK10.37033058
142AURKA0.36931945
143MAPKAPK50.36822283
144AKT10.36081305
145CDK90.35852110
146RPS6KA20.35165633
147CDK11A0.34177272
148RPS6KA30.34117893
149CSNK1A10.34062616
150PRKACA0.34012905

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.65129572
2Nicotine addiction_Homo sapiens_hsa050332.15371096
3Basal cell carcinoma_Homo sapiens_hsa052172.12923135
4Insulin secretion_Homo sapiens_hsa049111.95239118
5Axon guidance_Homo sapiens_hsa043601.91770725
6Hedgehog signaling pathway_Homo sapiens_hsa043401.88687710
7Phototransduction_Homo sapiens_hsa047441.82279685
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69469995
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67797523
10Dopaminergic synapse_Homo sapiens_hsa047281.65746866
11Basal transcription factors_Homo sapiens_hsa030221.56747940
12Homologous recombination_Homo sapiens_hsa034401.55187684
13RNA polymerase_Homo sapiens_hsa030201.49919245
14Hippo signaling pathway_Homo sapiens_hsa043901.49337893
15Wnt signaling pathway_Homo sapiens_hsa043101.48488805
16Cardiac muscle contraction_Homo sapiens_hsa042601.46905330
17Nitrogen metabolism_Homo sapiens_hsa009101.44776307
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42452810
19Notch signaling pathway_Homo sapiens_hsa043301.41656473
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37104867
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36930246
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36627930
23Sphingolipid metabolism_Homo sapiens_hsa006001.31946269
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29212488
25Taste transduction_Homo sapiens_hsa047421.27212747
26Spliceosome_Homo sapiens_hsa030401.27010569
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.26056475
28Serotonergic synapse_Homo sapiens_hsa047261.25016773
29Ether lipid metabolism_Homo sapiens_hsa005651.24416460
30ECM-receptor interaction_Homo sapiens_hsa045121.21371678
31mRNA surveillance pathway_Homo sapiens_hsa030151.21116092
32Butanoate metabolism_Homo sapiens_hsa006501.19915295
33Non-homologous end-joining_Homo sapiens_hsa034501.18904969
34Synaptic vesicle cycle_Homo sapiens_hsa047211.17526570
35Gastric acid secretion_Homo sapiens_hsa049711.16024102
36Mismatch repair_Homo sapiens_hsa034301.15702644
37Salivary secretion_Homo sapiens_hsa049701.14409389
38Glutamatergic synapse_Homo sapiens_hsa047241.13286824
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13268852
40Autoimmune thyroid disease_Homo sapiens_hsa053201.10871753
41Renin secretion_Homo sapiens_hsa049241.07091849
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05954857
43MicroRNAs in cancer_Homo sapiens_hsa052061.05665479
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.05311485
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03667533
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03422592
47TGF-beta signaling pathway_Homo sapiens_hsa043501.03371437
48Arachidonic acid metabolism_Homo sapiens_hsa005901.02813376
49Cell cycle_Homo sapiens_hsa041101.00789339
50Steroid biosynthesis_Homo sapiens_hsa001000.99851200
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98694812
52Nucleotide excision repair_Homo sapiens_hsa034200.98676895
53Melanoma_Homo sapiens_hsa052180.98400621
54p53 signaling pathway_Homo sapiens_hsa041150.97999213
55Melanogenesis_Homo sapiens_hsa049160.95040727
56Propanoate metabolism_Homo sapiens_hsa006400.93237968
57Morphine addiction_Homo sapiens_hsa050320.93050605
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92412143
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91440286
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90097464
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87819340
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87357991
63Long-term potentiation_Homo sapiens_hsa047200.86577706
64Protein export_Homo sapiens_hsa030600.84728890
65Pathways in cancer_Homo sapiens_hsa052000.82848874
66Ovarian steroidogenesis_Homo sapiens_hsa049130.82352636
67Circadian rhythm_Homo sapiens_hsa047100.81280222
68Tight junction_Homo sapiens_hsa045300.81268793
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81054096
70Adherens junction_Homo sapiens_hsa045200.80920053
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80324529
72beta-Alanine metabolism_Homo sapiens_hsa004100.79864953
73Ras signaling pathway_Homo sapiens_hsa040140.79683850
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78594485
75Long-term depression_Homo sapiens_hsa047300.77009936
76Dorso-ventral axis formation_Homo sapiens_hsa043200.75976549
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74712816
78Base excision repair_Homo sapiens_hsa034100.73950218
79Thyroid hormone synthesis_Homo sapiens_hsa049180.73136604
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72611903
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.72112736
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71427886
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71382804
84Calcium signaling pathway_Homo sapiens_hsa040200.70660669
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70639835
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68890515
87Cocaine addiction_Homo sapiens_hsa050300.67853661
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67359190
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66814867
90Graft-versus-host disease_Homo sapiens_hsa053320.66121463
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65995256
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65500597
93Linoleic acid metabolism_Homo sapiens_hsa005910.65288349
94RNA degradation_Homo sapiens_hsa030180.64530800
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64519880
96GABAergic synapse_Homo sapiens_hsa047270.64476508
97Circadian entrainment_Homo sapiens_hsa047130.64336253
98ErbB signaling pathway_Homo sapiens_hsa040120.64088075
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63423138
100Type II diabetes mellitus_Homo sapiens_hsa049300.62914266
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62414757
102ABC transporters_Homo sapiens_hsa020100.62235976
103Prostate cancer_Homo sapiens_hsa052150.62222823
104DNA replication_Homo sapiens_hsa030300.61008018
105Ribosome_Homo sapiens_hsa030100.60042872
106MAPK signaling pathway_Homo sapiens_hsa040100.59592621
107Rap1 signaling pathway_Homo sapiens_hsa040150.58664689
108Amphetamine addiction_Homo sapiens_hsa050310.58663017
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58582892
110Choline metabolism in cancer_Homo sapiens_hsa052310.57956954
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55113491
112Glycerolipid metabolism_Homo sapiens_hsa005610.54547024
113Tryptophan metabolism_Homo sapiens_hsa003800.53214863
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53153331
115Selenocompound metabolism_Homo sapiens_hsa004500.52997258
116Huntingtons disease_Homo sapiens_hsa050160.52446848
117Cholinergic synapse_Homo sapiens_hsa047250.52319543
118Pyrimidine metabolism_Homo sapiens_hsa002400.52108504
119Pancreatic secretion_Homo sapiens_hsa049720.51851307
120Bile secretion_Homo sapiens_hsa049760.51359039
121Alcoholism_Homo sapiens_hsa050340.50292158
122Allograft rejection_Homo sapiens_hsa053300.49142656
123Viral myocarditis_Homo sapiens_hsa054160.48876417
124Estrogen signaling pathway_Homo sapiens_hsa049150.48731332
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48057316
126Olfactory transduction_Homo sapiens_hsa047400.47592698
127Asthma_Homo sapiens_hsa053100.47507294
128Focal adhesion_Homo sapiens_hsa045100.47465748
129Colorectal cancer_Homo sapiens_hsa052100.47291562
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.47046152
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.46327430
132Purine metabolism_Homo sapiens_hsa002300.46255902
133GnRH signaling pathway_Homo sapiens_hsa049120.46013921
134Gap junction_Homo sapiens_hsa045400.45302540
135RNA transport_Homo sapiens_hsa030130.44975213
136Small cell lung cancer_Homo sapiens_hsa052220.44031713
137Protein digestion and absorption_Homo sapiens_hsa049740.44027156
138Oxytocin signaling pathway_Homo sapiens_hsa049210.43419258
139cAMP signaling pathway_Homo sapiens_hsa040240.43415457
140Lysine degradation_Homo sapiens_hsa003100.43167037
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39937823

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