DENND1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.29417001
2central nervous system myelination (GO:0022010)7.29417001
3fatty acid elongation (GO:0030497)4.49818578
4long-chain fatty acid biosynthetic process (GO:0042759)4.17891944
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.16838039
6axon ensheathment (GO:0008366)3.91004649
7ensheathment of neurons (GO:0007272)3.91004649
8myelination (GO:0042552)3.89467824
9negative regulation of neurotransmitter secretion (GO:0046929)3.74513762
10cellular extravasation (GO:0045123)3.71660350
11import into cell (GO:0098657)3.65944233
12neutrophil activation involved in immune response (GO:0002283)3.52007972
13cellular response to ethanol (GO:0071361)3.51550298
14response to peptidoglycan (GO:0032494)3.42425068
15regulation of B cell receptor signaling pathway (GO:0050855)3.39044962
16L-amino acid import (GO:0043092)3.33340096
17histone H3-K4 trimethylation (GO:0080182)3.27529985
18neural tube formation (GO:0001841)3.26802363
19positive regulation of interleukin-17 production (GO:0032740)3.24351156
20regulation of activation of Janus kinase activity (GO:0010533)3.22496695
21negative regulation of neurotransmitter transport (GO:0051589)3.20869954
22response to lipoprotein particle (GO:0055094)3.16953657
23regulation of T cell tolerance induction (GO:0002664)3.16162596
24hepatocyte apoptotic process (GO:0097284)3.15291011
25regulation of gamma-delta T cell activation (GO:0046643)3.14215694
26positive regulation of oligodendrocyte differentiation (GO:0048714)3.08327083
27positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06290122
28regulation of tolerance induction (GO:0002643)3.04743498
29immunoglobulin mediated immune response (GO:0016064)3.04393371
30interferon-gamma-mediated signaling pathway (GO:0060333)3.02112959
31negative T cell selection (GO:0043383)3.00432227
32response to redox state (GO:0051775)3.00290446
33neutrophil activation (GO:0042119)3.00008937
34presynaptic membrane assembly (GO:0097105)2.99576692
35regulation of gamma-delta T cell differentiation (GO:0045586)2.97347964
36positive regulation of B cell differentiation (GO:0045579)2.95427307
37eye photoreceptor cell differentiation (GO:0001754)2.95118950
38photoreceptor cell differentiation (GO:0046530)2.95118950
39presynaptic membrane organization (GO:0097090)2.93911566
40negative regulation of interleukin-12 production (GO:0032695)2.93838134
41negative thymic T cell selection (GO:0045060)2.91649525
42GPI anchor biosynthetic process (GO:0006506)2.90982636
43glycerophospholipid catabolic process (GO:0046475)2.89394349
44GPI anchor metabolic process (GO:0006505)2.86804978
45regulation of pigment cell differentiation (GO:0050932)2.83884796
46superoxide anion generation (GO:0042554)2.82562633
47preassembly of GPI anchor in ER membrane (GO:0016254)2.82498409
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80166441
49positive regulation of cell fate commitment (GO:0010455)2.78836397
50neutrophil mediated immunity (GO:0002446)2.78616999
51negative regulation of execution phase of apoptosis (GO:1900118)2.78493727
52negative regulation of T cell mediated immunity (GO:0002710)2.78233149
53isoprenoid biosynthetic process (GO:0008299)2.77966223
54nucleotide transmembrane transport (GO:1901679)2.77960726
55T-helper 1 type immune response (GO:0042088)2.77832109
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77613510
57negative regulation of cell killing (GO:0031342)2.77613510
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76986337
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76512443
60positive regulation of granulocyte differentiation (GO:0030854)2.74670549
61oligodendrocyte differentiation (GO:0048709)2.73112802
62establishment of protein localization to Golgi (GO:0072600)2.72783257
63developmental pigmentation (GO:0048066)2.72080834
64negative regulation of B cell proliferation (GO:0030889)2.71361780
65regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.69250401
66myelin maintenance (GO:0043217)2.68448712
67granulocyte activation (GO:0036230)2.68022567
68positive regulation of cellular amide metabolic process (GO:0034250)2.67588069
69myeloid cell activation involved in immune response (GO:0002275)2.65242810
70positive regulation of type 2 immune response (GO:0002830)2.64673645
71positive T cell selection (GO:0043368)2.64346965
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.62243117
73cholesterol biosynthetic process (GO:0006695)2.61804188
74cytidine catabolic process (GO:0006216)2.60932329
75cytidine deamination (GO:0009972)2.60932329
76cytidine metabolic process (GO:0046087)2.60932329
77B cell receptor signaling pathway (GO:0050853)2.59348507
78myeloid leukocyte mediated immunity (GO:0002444)2.58534470
79activated T cell proliferation (GO:0050798)2.57556491
80regulation of T-helper 1 cell differentiation (GO:0045625)2.57503327
81peptidyl-lysine trimethylation (GO:0018023)2.56741329
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.56438530
83regulation of memory T cell differentiation (GO:0043380)2.56257091
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.55738544
85cell wall macromolecule catabolic process (GO:0016998)2.55669097
86negative regulation of protein localization to cell surface (GO:2000009)2.55382331
87positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.55277398
88detection of molecule of bacterial origin (GO:0032490)2.55021160
89protein targeting to Golgi (GO:0000042)2.54988652
90production of molecular mediator involved in inflammatory response (GO:0002532)2.54523417
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54442632
92macrophage activation involved in immune response (GO:0002281)2.52932524
93negative regulation of exocytosis (GO:0045920)2.52858946
94T cell activation involved in immune response (GO:0002286)2.52637297
95positive regulation of tolerance induction (GO:0002645)2.52090844
96leukocyte migration involved in inflammatory response (GO:0002523)2.51809175
97retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51377026
98nerve growth factor signaling pathway (GO:0038180)2.50778776
99regulation of somitogenesis (GO:0014807)2.50630456
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50334421
101antigen processing and presentation of endogenous antigen (GO:0019883)2.49707399
102organelle membrane fusion (GO:0090174)2.49658434
103interleukin-6-mediated signaling pathway (GO:0070102)2.48061912
104T cell differentiation involved in immune response (GO:0002292)2.47646351
105alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47646351
106alpha-beta T cell activation involved in immune response (GO:0002287)2.47646351
107T cell costimulation (GO:0031295)2.47605246
108microglial cell activation (GO:0001774)2.47417284
109regulation of collateral sprouting (GO:0048670)2.47245312
110regulation of regulatory T cell differentiation (GO:0045589)2.46676024
111limb bud formation (GO:0060174)2.46553055
112T-helper cell differentiation (GO:0042093)2.46467519
113CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46467519
114regulation of interleukin-17 production (GO:0032660)2.46195802
115negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.44493120
116negative regulation of translation, ncRNA-mediated (GO:0040033)2.44493120
117regulation of translation, ncRNA-mediated (GO:0045974)2.44493120
118Rap protein signal transduction (GO:0032486)2.44483038
119regulation of germinal center formation (GO:0002634)2.44135383
120monocyte chemotaxis (GO:0002548)2.43939366
121positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.43835262
122regulation of interleukin-12 biosynthetic process (GO:0045075)2.43539231
123necrotic cell death (GO:0070265)2.43228867
124lymphocyte costimulation (GO:0031294)2.42943110
125amino acid import (GO:0043090)2.42911753
126histone H3-K36 demethylation (GO:0070544)2.42710343
127regulation of protein glycosylation (GO:0060049)2.42360988
128positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.42153522
129negative regulation of interleukin-17 production (GO:0032700)2.41555157
130amyloid precursor protein metabolic process (GO:0042982)2.41274945
131prenylation (GO:0097354)2.41094829
132protein prenylation (GO:0018342)2.41094829
133positive regulation of T cell cytokine production (GO:0002726)2.40506906
134detection of other organism (GO:0098543)2.39742657
135positive regulation of gamma-delta T cell activation (GO:0046645)2.39446354
136positive regulation of mast cell activation (GO:0033005)2.39341158
137angiotensin maturation (GO:0002003)2.39068546
138auditory receptor cell differentiation (GO:0042491)2.38210935
139cell wall macromolecule metabolic process (GO:0044036)2.37795890
140polyol transport (GO:0015791)2.37338593
141positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36764755
142mRNA modification (GO:0016556)2.35688002
143interkinetic nuclear migration (GO:0022027)2.35669341
144negative regulation of lipid storage (GO:0010888)2.35508106
145regulation of NIK/NF-kappaB signaling (GO:1901222)2.35079014
146positive regulation of interleukin-1 beta secretion (GO:0050718)2.35044585
147Golgi to endosome transport (GO:0006895)2.35018118
148regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.34908583
149glycosphingolipid catabolic process (GO:0046479)2.34617516
150positive regulation of antigen processing and presentation (GO:0002579)2.34010727
151regulation of T cell migration (GO:2000404)2.33935520
152eosinophil chemotaxis (GO:0048245)2.33401278
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.32788906
154dendritic cell migration (GO:0036336)2.31846184
155B cell homeostasis (GO:0001782)2.31335518
156sterol biosynthetic process (GO:0016126)2.30455536
157positive regulation of interleukin-2 production (GO:0032743)2.30438205
158positive regulation of defense response to virus by host (GO:0002230)2.30369772
159regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.29975168
160germinal center formation (GO:0002467)2.29606732
161magnesium ion transport (GO:0015693)2.29445233
162CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.29312206
163modulation by symbiont of host immune response (GO:0052553)2.28147590
164positive regulation by symbiont of host defense response (GO:0052509)2.28147590
165modulation by symbiont of host defense response (GO:0052031)2.28147590
166modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.28147590
167modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.28147590
168positive regulation by organism of defense response of other organism involved in symbiotic interact2.28147590
169regulation of alpha-beta T cell proliferation (GO:0046640)2.27831096
170mature B cell differentiation (GO:0002335)2.27779370
171positive regulation of action potential (GO:0045760)2.25458763
172retina layer formation (GO:0010842)2.24697688
173respiratory burst (GO:0045730)2.23071759
174T cell migration (GO:0072678)2.22626219
175regulation of platelet aggregation (GO:0090330)2.22321693
176leukocyte aggregation (GO:0070486)2.22098707
177dendritic cell chemotaxis (GO:0002407)2.22096090
178positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.21735048
179positive regulation of T cell migration (GO:2000406)2.21452647
180cyclic nucleotide catabolic process (GO:0009214)2.20459018
181positive regulation of cellular amine metabolic process (GO:0033240)2.20242079
182positive regulation of smooth muscle cell migration (GO:0014911)2.19510871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81335305
2GBX2_23144817_ChIP-Seq_PC3_Human3.12219344
3ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51003645
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45186366
5* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42247154
6TAF15_26573619_Chip-Seq_HEK293_Human2.41420495
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.37590912
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35847873
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.29788398
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26194394
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.20166156
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17951258
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.13114246
14PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09758843
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09517543
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98006661
17* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95226620
18* EZH2_27294783_Chip-Seq_NPCs_Mouse1.89531432
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88572203
20* NFE2_27457419_Chip-Seq_LIVER_Mouse1.84536167
21SCL_19346495_ChIP-Seq_HPC-7_Human1.81775775
22* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81129161
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80638923
24* NANOG_18555785_Chip-Seq_ESCs_Mouse1.78570393
25ER_23166858_ChIP-Seq_MCF-7_Human1.78184259
26* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78173979
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.77441897
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77392052
29* IRF8_27001747_Chip-Seq_BMDM_Mouse1.73576256
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71672445
31* CMYC_18555785_Chip-Seq_ESCs_Mouse1.71143580
32P300_19829295_ChIP-Seq_ESCs_Human1.71039989
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70379425
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70027046
35* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.69298977
36* E2F1_18555785_Chip-Seq_ESCs_Mouse1.68641214
37FUS_26573619_Chip-Seq_HEK293_Human1.67775556
38* MYB_26560356_Chip-Seq_TH2_Human1.67636667
39* P300_18555785_Chip-Seq_ESCs_Mouse1.66773748
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66033942
41* P53_22387025_ChIP-Seq_ESCs_Mouse1.64822851
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64773816
43* STAT3_18555785_Chip-Seq_ESCs_Mouse1.62997480
44* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.59233724
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58096278
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.57287421
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56340875
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54303542
49* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52839127
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52576604
51* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.51476452
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51291772
53* NMYC_18555785_Chip-Seq_ESCs_Mouse1.48218493
54RUNX_20019798_ChIP-Seq_JUKART_Human1.47333481
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46674871
56* OCT4_18555785_Chip-Seq_ESCs_Mouse1.46630576
57GATA1_22025678_ChIP-Seq_K562_Human1.45673709
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44158143
59EWS_26573619_Chip-Seq_HEK293_Human1.43427454
60* SOX2_18555785_Chip-Seq_ESCs_Mouse1.41067938
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.40378759
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40039879
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39792767
64* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39618568
65* PU1_27457419_Chip-Seq_LIVER_Mouse1.38942446
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.38878822
67VDR_22108803_ChIP-Seq_LS180_Human1.38450784
68NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38382515
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38382515
70* KLF4_18555785_Chip-Seq_ESCs_Mouse1.38063239
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37484911
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35849832
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35705220
74* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35340753
75GATA3_27048872_Chip-Seq_THYMUS_Human1.33663756
76* ZFX_18555785_Chip-Seq_ESCs_Mouse1.32173155
77* CRX_20693478_ChIP-Seq_RETINA_Mouse1.32067978
78TP53_16413492_ChIP-PET_HCT116_Human1.29561844
79* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28496341
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.28375161
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28073592
82* CTCF_18555785_Chip-Seq_ESCs_Mouse1.27861478
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24936130
84* STAT3_23295773_ChIP-Seq_U87_Human1.24726270
85IRF1_19129219_ChIP-ChIP_H3396_Human1.22627980
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22309914
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21261457
88* SMAD4_21799915_ChIP-Seq_A2780_Human1.20246257
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19724075
90* TCF4_23295773_ChIP-Seq_U87_Human1.19452804
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19206278
92* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19099578
93GATA3_26560356_Chip-Seq_TH2_Human1.18474376
94* MYB_26560356_Chip-Seq_TH1_Human1.17873715
95* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17729671
96* SPI1_23547873_ChIP-Seq_NB4_Human1.17636171
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16107205
98AR_21572438_ChIP-Seq_LNCaP_Human1.16019886
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15408847
100EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15148714
101* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15021817
102VDR_24787735_ChIP-Seq_THP-1_Human1.13827779
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13759166
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13747778
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12029060
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.11863150
107CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09743413
108TP53_18474530_ChIP-ChIP_U2OS_Human1.09038923
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08757762
110BCAT_22108803_ChIP-Seq_LS180_Human1.08654871
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07883301
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07837256
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07837256
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07395521
115CBX2_27304074_Chip-Seq_ESCs_Mouse1.07033220
116SPI1_23127762_ChIP-Seq_K562_Human1.06606278
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06128253
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.05970269
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05423572
120AHR_22903824_ChIP-Seq_MCF-7_Human1.05385884
121IGF1R_20145208_ChIP-Seq_DFB_Human1.05260649
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04635331
123KDM2B_26808549_Chip-Seq_REH_Human1.03963870
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03660175
125CBP_20019798_ChIP-Seq_JUKART_Human1.03660175
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03254135
127STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02301613
128CDX2_22108803_ChIP-Seq_LS180_Human1.02012314
129* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01396948
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.01043005
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00954269
132FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00655126
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.99999789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.67956783
2MP0000920_abnormal_myelination3.68848181
3MP0004381_abnormal_hair_follicle3.49096688
4MP0005409_darkened_coat_color3.47749245
5MP0005171_absent_coat_pigmentation3.11822902
6MP0003950_abnormal_plasma_membrane3.01210674
7MP0001835_abnormal_antigen_presentation2.83522627
8MP0003690_abnormal_glial_cell2.59956521
9MP0003300_gastrointestinal_ulcer2.54375519
10MP0005387_immune_system_phenotype2.40158351
11MP0001790_abnormal_immune_system2.40158351
12MP0001188_hyperpigmentation2.39499293
13MP0004742_abnormal_vestibular_system2.39303116
14MP0000383_abnormal_hair_follicle2.35057538
15MP0001986_abnormal_taste_sensitivity2.32621909
16MP0002148_abnormal_hypersensitivity_rea2.30109091
17MP0000015_abnormal_ear_pigmentation2.19933081
18MP0006082_CNS_inflammation2.18034812
19MP0005671_abnormal_response_to2.13923185
20MP0005000_abnormal_immune_tolerance2.12684993
21MP0003724_increased_susceptibility_to2.11532831
22MP0008260_abnormal_autophagy2.09536708
23MP0003646_muscle_fatigue1.99384564
24MP0002277_abnormal_respiratory_mucosa1.98147902
25MP0002419_abnormal_innate_immunity1.96852477
26MP0001800_abnormal_humoral_immune1.96275188
27MP0000566_synostosis1.93230606
28MP0009785_altered_susceptibility_to1.87346342
29MP0005174_abnormal_tail_pigmentation1.86993656
30MP0003172_abnormal_lysosome_physiology1.80054170
31MP0002723_abnormal_immune_serum1.80023878
32MP0004264_abnormal_extraembryonic_tissu1.79796148
33MP0002452_abnormal_antigen_presenting1.78974225
34MP0010678_abnormal_skin_adnexa1.76674906
35MP0005451_abnormal_body_composition1.70507947
36MP0005025_abnormal_response_to1.69042149
37MP0006292_abnormal_olfactory_placode1.63290809
38MP0003787_abnormal_imprinting1.55611973
39MP0002420_abnormal_adaptive_immunity1.55370422
40MP0001819_abnormal_immune_cell1.55040342
41MP0003191_abnormal_cellular_cholesterol1.54713948
42MP0003828_pulmonary_edema1.52797811
43MP0005075_abnormal_melanosome_morpholog1.42695630
44MP0008057_abnormal_DNA_replication1.42421729
45MP0002139_abnormal_hepatobiliary_system1.42054602
46MP0002009_preneoplasia1.41896874
47MP0004134_abnormal_chest_morphology1.41273088
48MP0000685_abnormal_immune_system1.37427055
49MP0001486_abnormal_startle_reflex1.32008886
50MP0005551_abnormal_eye_electrophysiolog1.31921078
51MP0004043_abnormal_pH_regulation1.31459398
52MP0002396_abnormal_hematopoietic_system1.30433764
53MP0003866_abnormal_defecation1.28177207
54MP0004947_skin_inflammation1.25114083
55MP0004142_abnormal_muscle_tone1.24631917
56MP0000372_irregular_coat_pigmentation1.23358742
57MP0001485_abnormal_pinna_reflex1.20849473
58MP0000371_diluted_coat_color1.20384970
59MP0001905_abnormal_dopamine_level1.19697611
60MP0008469_abnormal_protein_level1.17297824
61MP0000569_abnormal_digit_pigmentation1.16129996
62MP0000465_gastrointestinal_hemorrhage1.13923441
63MP0003656_abnormal_erythrocyte_physiolo1.13376146
64MP0005310_abnormal_salivary_gland1.11767695
65MP0003632_abnormal_nervous_system1.11739860
66MP0001853_heart_inflammation1.10645532
67MP0005085_abnormal_gallbladder_physiolo1.09615642
68MP0002405_respiratory_system_inflammati1.09601684
69MP0000716_abnormal_immune_system1.09419936
70MP0004036_abnormal_muscle_relaxation1.09258221
71MP0001545_abnormal_hematopoietic_system1.09136283
72MP0005397_hematopoietic_system_phenotyp1.09136283
73MP0003763_abnormal_thymus_physiology1.07133267
74MP0008004_abnormal_stomach_pH1.06789874
75MP0003436_decreased_susceptibility_to1.06434755
76MP0001851_eye_inflammation1.06100958
77MP0001873_stomach_inflammation1.03963570
78MP0003634_abnormal_glial_cell1.03900974
79MP0003195_calcinosis1.03770707
80MP0002933_joint_inflammation1.03307812
81MP0002822_catalepsy1.02052999
82MP0003183_abnormal_peptide_metabolism0.99959759
83MP0003252_abnormal_bile_duct0.99161611
84MP0001661_extended_life_span0.98420995
85MP0002229_neurodegeneration0.97697372
86MP0001963_abnormal_hearing_physiology0.97004115
87MP0002095_abnormal_skin_pigmentation0.93098947
88MP0004885_abnormal_endolymph0.92918513
89MP0005248_abnormal_Harderian_gland0.92477893
90MP0004484_altered_response_of0.92147596
91MP0002163_abnormal_gland_morphology0.92084187
92MP0004145_abnormal_muscle_electrophysio0.91861922
93MP0002722_abnormal_immune_system0.91826318
94MP0002998_abnormal_bone_remodeling0.91699599
95MP0004782_abnormal_surfactant_physiolog0.88856165
96MP0004084_abnormal_cardiac_muscle0.88638347
97MP0003045_fibrosis0.88595683
98MP0000026_abnormal_inner_ear0.86919917
99MP0010155_abnormal_intestine_physiology0.85459428
100MP0005360_urolithiasis0.85226195
101MP0003880_abnormal_central_pattern0.84919301
102MP0004883_abnormal_blood_vessel0.84493663
103MP0005195_abnormal_posterior_eye0.84220664
104MP0000778_abnormal_nervous_system0.83973452
105MP0005166_decreased_susceptibility_to0.83705904
106MP0002398_abnormal_bone_marrow0.83515557
107MP0005253_abnormal_eye_physiology0.82757521
108MP0004510_myositis0.81536419
109MP0009764_decreased_sensitivity_to0.80047000
110MP0002332_abnormal_exercise_endurance0.79937001
111MP0004808_abnormal_hematopoietic_stem0.79338724
112MP0005408_hypopigmentation0.79287909
113MP0009333_abnormal_splenocyte_physiolog0.78690938
114MP0002138_abnormal_hepatobiliary_system0.78152411
115MP0003448_altered_tumor_morphology0.77961482
116MP0005423_abnormal_somatic_nervous0.77888032
117MP0009115_abnormal_fat_cell0.77624597
118MP0009765_abnormal_xenobiotic_induced0.76858875
119MP0002006_tumorigenesis0.76693012
120MP0001845_abnormal_inflammatory_respons0.76168382
121MP0010386_abnormal_urinary_bladder0.75908410
122MP0010352_gastrointestinal_tract_polyps0.74702898
123MP0002272_abnormal_nervous_system0.73904023
124MP0002102_abnormal_ear_morphology0.72822637
125MP0002166_altered_tumor_susceptibility0.72617276
126MP0003937_abnormal_limbs/digits/tail_de0.71469943
127MP0000604_amyloidosis0.71138554
128MP0005365_abnormal_bile_salt0.69980426
129MP0005410_abnormal_fertilization0.69530219
130MP0002136_abnormal_kidney_physiology0.69252909
131MP0000427_abnormal_hair_cycle0.69087114
132MP0000689_abnormal_spleen_morphology0.68485961
133MP0005379_endocrine/exocrine_gland_phen0.67873075
134MP0001324_abnormal_eye_pigmentation0.67810970
135MP0005058_abnormal_lysosome_morphology0.66476181
136MP0005464_abnormal_platelet_physiology0.65908118
137MP0003631_nervous_system_phenotype0.65501082
138MP0000647_abnormal_sebaceous_gland0.64668629
139MP0002429_abnormal_blood_cell0.64454704
140MP0003303_peritoneal_inflammation0.63683131
141MP0001529_abnormal_vocalization0.62967298
142MP0002133_abnormal_respiratory_system0.62160262
143MP0005388_respiratory_system_phenotype0.62160262
144MP0005645_abnormal_hypothalamus_physiol0.61411353

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.64194000
2Degeneration of the lateral corticospinal tracts (HP:0002314)3.75125957
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.75125957
4Metaphyseal dysplasia (HP:0100255)3.72019240
5Abnormality of liposaccharide metabolism (HP:0010968)3.62776657
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.62776657
7Abnormality of glycolipid metabolism (HP:0010969)3.62776657
8Duplicated collecting system (HP:0000081)3.61961515
9Abnormality of the renal collecting system (HP:0004742)3.39816663
10Prostate neoplasm (HP:0100787)3.14663497
11Stomatitis (HP:0010280)3.14469798
12Recurrent abscess formation (HP:0002722)3.12499133
13Septo-optic dysplasia (HP:0100842)3.09462686
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05733636
15White forelock (HP:0002211)3.05055513
16Patchy hypopigmentation of hair (HP:0011365)2.92100535
17Neoplasm of the tracheobronchial system (HP:0100552)2.89695685
18Absent septum pellucidum (HP:0001331)2.85687548
19Autoimmune thrombocytopenia (HP:0001973)2.81229640
20Vacuolated lymphocytes (HP:0001922)2.80165164
21Recurrent bacterial skin infections (HP:0005406)2.78657038
22Agammaglobulinemia (HP:0004432)2.75440215
23Hemoptysis (HP:0002105)2.73241582
24Neonatal hypoglycemia (HP:0001998)2.69369902
25Abnormality of the nasal septum (HP:0000419)2.68121792
26Chromsome breakage (HP:0040012)2.67847168
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.64789387
28Alveolar cell carcinoma (HP:0006519)2.62469876
29Abnormality of the septum pellucidum (HP:0007375)2.59257978
30Sensory axonal neuropathy (HP:0003390)2.56622840
31Elevated erythrocyte sedimentation rate (HP:0003565)2.53462763
32Chest pain (HP:0100749)2.51744161
33Recurrent pneumonia (HP:0006532)2.51126996
34Papillary thyroid carcinoma (HP:0002895)2.50009079
35Optic neuritis (HP:0100653)2.48532178
36Retrobulbar optic neuritis (HP:0100654)2.48532178
37Recurrent skin infections (HP:0001581)2.48299576
38Thyroiditis (HP:0100646)2.46343633
39T lymphocytopenia (HP:0005403)2.44971895
40Eczematoid dermatitis (HP:0000976)2.44299623
41Stomach cancer (HP:0012126)2.43799940
42Gastrointestinal infarctions (HP:0005244)2.43414907
43Abnormality of T cells (HP:0002843)2.42545211
44Abnormality of macrophages (HP:0004311)2.39305774
45Abnormality of T cell number (HP:0011839)2.38391010
46Colitis (HP:0002583)2.37505090
47Recurrent bronchitis (HP:0002837)2.36914567
48Anomalous pulmonary venous return (HP:0010772)2.36253013
49Leukocytosis (HP:0001974)2.36075523
50Myositis (HP:0100614)2.35553347
51Abnormality of B cell number (HP:0010975)2.34879914
52Cupped ear (HP:0000378)2.34259170
53Pulmonary infiltrates (HP:0002113)2.33704548
54Submucous cleft hard palate (HP:0000176)2.33142463
55Peripheral hypomyelination (HP:0007182)2.32883853
56Onion bulb formation (HP:0003383)2.32285233
57Recurrent cutaneous fungal infections (HP:0011370)2.32169496
58Chronic mucocutaneous candidiasis (HP:0002728)2.32169496
59Congenital sensorineural hearing impairment (HP:0008527)2.30572179
60Chronic diarrhea (HP:0002028)2.30440971
61Abnormality of the left ventricular outflow tract (HP:0011103)2.27922064
62Subaortic stenosis (HP:0001682)2.27922064
63Slow saccadic eye movements (HP:0000514)2.27782679
64Enlarged epiphyses (HP:0010580)2.27748126
65Absent frontal sinuses (HP:0002688)2.26114617
66Vasculitis (HP:0002633)2.24443078
67Prolonged neonatal jaundice (HP:0006579)2.22771628
68Orchitis (HP:0100796)2.21332283
69Recurrent fungal infections (HP:0002841)2.20687085
70Decreased central vision (HP:0007663)2.19939746
71Thickened calvaria (HP:0002684)2.19587353
72Diastasis recti (HP:0001540)2.18412090
73Hypoplasia of the iris (HP:0007676)2.17740785
74Albinism (HP:0001022)2.15335772
75Abnormality of eosinophils (HP:0001879)2.15150908
76Obstructive lung disease (HP:0006536)2.14158394
77Chronic obstructive pulmonary disease (HP:0006510)2.14158394
78Neurofibrillary tangles (HP:0002185)2.12774621
79Thick nail (HP:0001805)2.12486496
80Abnormality of the axillary hair (HP:0100134)2.11058260
81Abnormality of secondary sexual hair (HP:0009888)2.11058260
82Hepatosplenomegaly (HP:0001433)2.10604646
83Meningitis (HP:0001287)2.08106248
84Ectropion (HP:0000656)2.05943039
85Acute myeloid leukemia (HP:0004808)2.05744997
86Abnormality of the pulmonary veins (HP:0011718)2.05736176
87Hyperventilation (HP:0002883)2.05377924
88Recurrent gram-negative bacterial infections (HP:0005420)2.04925077
89Abnormality of the corticospinal tract (HP:0002492)2.04698887
90Recurrent viral infections (HP:0004429)2.03346787
91Eosinophilia (HP:0001880)2.02306692
92Fair hair (HP:0002286)2.00750048
93Disinhibition (HP:0000734)1.97746045
94Recurrent lower respiratory tract infections (HP:0002783)1.97483999
95Increased cerebral lipofuscin (HP:0011813)1.97081061
96Interstitial pulmonary disease (HP:0006530)1.96758056
97Abnormality of the pleura (HP:0002103)1.94061078
98Abnormal delayed hypersensitivity skin test (HP:0002963)1.93844554
99Amaurosis fugax (HP:0100576)1.93617651
100Congenital ichthyosiform erythroderma (HP:0007431)1.93327363
101Abnormality of incisor morphology (HP:0011063)1.93316244
102Aplasia cutis congenita (HP:0001057)1.93160844
103Gingival bleeding (HP:0000225)1.92429567
104Gangrene (HP:0100758)1.92208096
105Urticaria (HP:0001025)1.91641205
106Spontaneous hematomas (HP:0007420)1.91296773
107Absent/shortened dynein arms (HP:0200106)1.91293481
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.91293481
109Erythroderma (HP:0001019)1.90707093
110Alacrima (HP:0000522)1.88833685
111Ectopic kidney (HP:0000086)1.88634652
112Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87803096
113Attenuation of retinal blood vessels (HP:0007843)1.87783453
114Depressed nasal tip (HP:0000437)1.87616676
115Pustule (HP:0200039)1.86989503
116Inflammation of the large intestine (HP:0002037)1.86873066
117Arterial thrombosis (HP:0004420)1.86052565
118Severe combined immunodeficiency (HP:0004430)1.85446287
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85438490
120Granulocytopenia (HP:0001913)1.84855177
121Curly hair (HP:0002212)1.82517782
122Mediastinal lymphadenopathy (HP:0100721)1.82440333
123Abnormality of the prostate (HP:0008775)1.82384864
124Hypophosphatemic rickets (HP:0004912)1.82094624
125Generalized hypopigmentation of hair (HP:0011358)1.80897960
126Thrombocytosis (HP:0001894)1.80763976
127Keratoconjunctivitis (HP:0001096)1.79747435
128Lip pit (HP:0100267)1.79740855
129Chin dimple (HP:0010751)1.79129578
130Decreased lacrimation (HP:0000633)1.78772703
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78606228
132Abnormality of the lumbar spine (HP:0100712)1.78088395
133Periodontitis (HP:0000704)1.77570167
134Duplication of thumb phalanx (HP:0009942)1.76740551
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.76497053
136Optic nerve hypoplasia (HP:0000609)1.76171013
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75583698
138Basal ganglia calcification (HP:0002135)1.75384605
139Dysostosis multiplex (HP:0000943)1.74653696
140Widely spaced teeth (HP:0000687)1.74427380
141Spondylolisthesis (HP:0003302)1.73385918
142Hematochezia (HP:0002573)1.73017545
143Subacute progressive viral hepatitis (HP:0006572)1.72372786
144Acute hepatic failure (HP:0006554)1.72235859
145Increased CSF protein (HP:0002922)1.71664069
146Encephalitis (HP:0002383)1.70931513
147Pruritus (HP:0000989)1.70615451
148Adrenal hypoplasia (HP:0000835)1.70293570
149Abnormal pancreas size (HP:0012094)1.69833491
150Anhidrosis (HP:0000970)1.69542370
151Asplenia (HP:0001746)1.68274711
152Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.67164765
153Panhypogammaglobulinemia (HP:0003139)1.66747914
154Segmental peripheral demyelination/remyelination (HP:0003481)1.66490815
155Pulmonary artery stenosis (HP:0004415)1.65808231
156Renal cortical cysts (HP:0000803)1.64906600
157Dyschromatopsia (HP:0007641)1.64548078
158Keratoconjunctivitis sicca (HP:0001097)1.64329669
159Abnormal hair whorl (HP:0010721)1.63941541
160Tubulointerstitial nephritis (HP:0001970)1.63369971
161Autoimmune hemolytic anemia (HP:0001890)1.63255374
162Osteomalacia (HP:0002749)1.63211760
163Gingivitis (HP:0000230)1.62839118
164Gastrointestinal stroma tumor (HP:0100723)1.62715823
165Conical tooth (HP:0000698)1.62513860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.58620027
2ACVR1B3.53481195
3CASK3.06720470
4MAP3K142.71667362
5EPHB12.61306083
6PKN12.33448844
7PBK2.29049004
8CLK12.28952575
9PIK3CG2.20982494
10MST42.20491576
11OXSR12.16860603
12IRAK42.07783561
13TXK2.05934233
14BLK1.93827949
15WNK31.88714163
16CAMKK21.74502453
17STK241.70081099
18ZAK1.69485499
19TNIK1.66364957
20YES11.59993138
21IRAK31.59012061
22BCR1.58893636
23INSRR1.48890382
24NEK61.47471384
25MKNK21.46170229
26TRPM71.45129717
27SCYL21.43136095
28BMPR1B1.42408436
29ERBB31.41021726
30WNK11.40060623
31NUAK11.34605603
32IKBKE1.30440214
33EIF2AK21.29614694
34MAP3K21.26048469
35NEK91.21941442
36FGR1.16267049
37ADRBK21.15093271
38CSNK1A1L1.13165514
39PRKCQ1.12647977
40MAP3K61.12523773
41PNCK1.09185366
42GRK71.08984348
43TEC1.08343021
44MKNK11.07746964
45BMPR21.07466912
46IKBKB1.05806124
47IRAK11.05360155
48MAP4K11.04713784
49FGFR21.03422373
50TAOK31.03188184
51TLK11.01859233
52GRK11.01852456
53MATK1.01296806
54RPS6KA51.00952332
55SGK31.00357788
56NLK0.99136077
57MAP2K40.98968013
58PRPF4B0.98410001
59JAK30.97256357
60CSK0.96336222
61MAP3K40.94703600
62MAPKAPK50.94526510
63IRAK20.93823313
64STK40.93701777
65BRD40.93114829
66JAK20.93012963
67MUSK0.92805206
68CAMK1G0.92438536
69ZAP700.91078734
70ITK0.90524340
71CSNK1G10.89756040
72LCK0.88905107
73MAP2K30.88494121
74SGK2230.88372453
75SGK4940.88372453
76KIT0.87171257
77JAK10.85323085
78PIK3CA0.84437602
79WNK40.83961926
80FRK0.83816172
81RIPK40.78555168
82HCK0.78273150
83CSF1R0.76999707
84SIK30.76783308
85MAPK130.75952449
86CSNK1G30.75813183
87CDK60.75576831
88EPHA30.74654791
89STK30.73989364
90MAP3K120.73718861
91MAP3K130.73581928
92MET0.72904968
93FES0.71494294
94DYRK1B0.71264318
95TNK20.71049414
96FER0.69758643
97TYK20.68102053
98SRPK10.66587804
99BTK0.66011808
100CDK30.66006444
101LYN0.65459561
102LATS10.64122698
103PRKCE0.64023092
104CAMK2B0.63427734
105ERBB40.61183017
106MARK30.60913571
107TBK10.57776028
108TRIM280.57042113
109PRKAA20.56607729
110MAP2K70.55439193
111FGFR30.54372386
112MAPK70.53893912
113AKT30.53550784
114CAMK2D0.53522098
115OBSCN0.52892763
116ROCK20.52452954
117ABL10.51793162
118MAP3K10.51284074
119STK38L0.50765223
120SYK0.50746240
121CAMK1D0.50427878
122MAPK150.49775917
123CHUK0.48922141
124PRKG10.48160924
125PIM10.48019557
126PRKD30.47859792
127ERBB20.47790080
128SGK20.47020545
129CSNK1D0.46092336
130PDK10.45985495
131MARK20.44858777
132MELK0.42587844
133CSNK1G20.41989837
134TAOK10.41878214
135TGFBR20.41486821
136PAK30.41429453
137CAMK40.40059275
138RET0.39418281
139DYRK30.38208713
140HIPK20.36956188

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.33283870
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90807174
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53207761
4Graft-versus-host disease_Homo sapiens_hsa053322.35187618
5Fatty acid elongation_Homo sapiens_hsa000622.34207433
6Autoimmune thyroid disease_Homo sapiens_hsa053202.32783847
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.30834964
8Ether lipid metabolism_Homo sapiens_hsa005652.30005248
9Allograft rejection_Homo sapiens_hsa053302.22832040
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19607255
11Primary immunodeficiency_Homo sapiens_hsa053402.05225678
12Sphingolipid metabolism_Homo sapiens_hsa006002.01575553
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.01255299
14Antigen processing and presentation_Homo sapiens_hsa046121.83549886
15Non-homologous end-joining_Homo sapiens_hsa034501.80307172
16Malaria_Homo sapiens_hsa051441.77254604
17Rheumatoid arthritis_Homo sapiens_hsa053231.67517193
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67450422
19Hematopoietic cell lineage_Homo sapiens_hsa046401.57447765
20Phototransduction_Homo sapiens_hsa047441.57099334
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.51200181
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48157238
23Asthma_Homo sapiens_hsa053101.46288487
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45041320
25Measles_Homo sapiens_hsa051621.44192117
26African trypanosomiasis_Homo sapiens_hsa051431.25997698
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25859126
28Staphylococcus aureus infection_Homo sapiens_hsa051501.24888164
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24537392
30Leishmaniasis_Homo sapiens_hsa051401.24083017
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22231982
32Non-small cell lung cancer_Homo sapiens_hsa052231.19224010
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18243207
34Fanconi anemia pathway_Homo sapiens_hsa034601.17354540
35Prolactin signaling pathway_Homo sapiens_hsa049171.16559445
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16028570
37Linoleic acid metabolism_Homo sapiens_hsa005911.13638753
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11850738
39Legionellosis_Homo sapiens_hsa051341.09932490
40Osteoclast differentiation_Homo sapiens_hsa043801.09567568
41Histidine metabolism_Homo sapiens_hsa003401.08844875
42B cell receptor signaling pathway_Homo sapiens_hsa046621.07530629
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07355176
44Protein export_Homo sapiens_hsa030601.06642528
45T cell receptor signaling pathway_Homo sapiens_hsa046601.04700557
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04454363
47Systemic lupus erythematosus_Homo sapiens_hsa053221.02929467
48Arachidonic acid metabolism_Homo sapiens_hsa005901.02884757
49Other glycan degradation_Homo sapiens_hsa005111.00949034
50Platelet activation_Homo sapiens_hsa046110.99093935
51Acute myeloid leukemia_Homo sapiens_hsa052210.98549590
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.98243300
53Pancreatic cancer_Homo sapiens_hsa052120.97740816
54Chemokine signaling pathway_Homo sapiens_hsa040620.97168769
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92737961
56Phagosome_Homo sapiens_hsa041450.90489416
57Axon guidance_Homo sapiens_hsa043600.89640868
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89525320
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89307299
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88259516
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.87070678
62Sulfur metabolism_Homo sapiens_hsa009200.86470112
63Pertussis_Homo sapiens_hsa051330.81788644
64Salmonella infection_Homo sapiens_hsa051320.78835906
65Tuberculosis_Homo sapiens_hsa051520.78707191
66Retinol metabolism_Homo sapiens_hsa008300.77897413
67Serotonergic synapse_Homo sapiens_hsa047260.77413590
68Herpes simplex infection_Homo sapiens_hsa051680.75164109
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.73785399
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73448489
71FoxO signaling pathway_Homo sapiens_hsa040680.73137162
72Insulin resistance_Homo sapiens_hsa049310.72136798
73Vitamin digestion and absorption_Homo sapiens_hsa049770.71445583
74Hepatitis C_Homo sapiens_hsa051600.70230103
75Mineral absorption_Homo sapiens_hsa049780.69765265
76ABC transporters_Homo sapiens_hsa020100.69716242
77TNF signaling pathway_Homo sapiens_hsa046680.69063728
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67657021
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.67080928
80Influenza A_Homo sapiens_hsa051640.67032750
81mTOR signaling pathway_Homo sapiens_hsa041500.66187338
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65910575
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.65654659
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64928598
85Caffeine metabolism_Homo sapiens_hsa002320.64383738
86Fatty acid biosynthesis_Homo sapiens_hsa000610.63402531
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61291301
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57985974
89Homologous recombination_Homo sapiens_hsa034400.57515458
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57312755
91Type I diabetes mellitus_Homo sapiens_hsa049400.56647191
92Viral myocarditis_Homo sapiens_hsa054160.56051152
93VEGF signaling pathway_Homo sapiens_hsa043700.55597222
94Chronic myeloid leukemia_Homo sapiens_hsa052200.54553960
95Ras signaling pathway_Homo sapiens_hsa040140.53896803
96Endometrial cancer_Homo sapiens_hsa052130.53851349
97Toxoplasmosis_Homo sapiens_hsa051450.52312743
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51954798
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50307474
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48825864
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45765976
102Lysosome_Homo sapiens_hsa041420.45645685
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.45478318
104Starch and sucrose metabolism_Homo sapiens_hsa005000.44894143
105PPAR signaling pathway_Homo sapiens_hsa033200.44023916
106Inositol phosphate metabolism_Homo sapiens_hsa005620.44018449
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.43748055
108Prostate cancer_Homo sapiens_hsa052150.43607908
109Choline metabolism in cancer_Homo sapiens_hsa052310.42853063
110Collecting duct acid secretion_Homo sapiens_hsa049660.41757751
111Apoptosis_Homo sapiens_hsa042100.41506041
112Dorso-ventral axis formation_Homo sapiens_hsa043200.40766846
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40719123
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39937776
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39754554
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39103236
117Renal cell carcinoma_Homo sapiens_hsa052110.38740463
118Basal transcription factors_Homo sapiens_hsa030220.38665127
119Ovarian steroidogenesis_Homo sapiens_hsa049130.38642907
120Notch signaling pathway_Homo sapiens_hsa043300.38622083
121MAPK signaling pathway_Homo sapiens_hsa040100.37905973
122Type II diabetes mellitus_Homo sapiens_hsa049300.37892156
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37863311
124Colorectal cancer_Homo sapiens_hsa052100.37336928
125Renin secretion_Homo sapiens_hsa049240.36540021
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36109594
127Taste transduction_Homo sapiens_hsa047420.35148623
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33285082
129Morphine addiction_Homo sapiens_hsa050320.33258176
130ECM-receptor interaction_Homo sapiens_hsa045120.33122112
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31710905
132ErbB signaling pathway_Homo sapiens_hsa040120.30457088
133Renin-angiotensin system_Homo sapiens_hsa046140.30094267
134Hepatitis B_Homo sapiens_hsa051610.28603441

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