DEFB109P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tongue development (GO:0043586)6.78304215
2potassium ion export (GO:0071435)6.07186258
3epithelial cilium movement (GO:0003351)5.95464412
4positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.79809608
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.53863007
6cilium movement (GO:0003341)5.24291509
7membrane repolarization during action potential (GO:0086011)5.09140377
8coenzyme catabolic process (GO:0009109)5.00736085
9axonemal dynein complex assembly (GO:0070286)4.75569923
10cGMP-mediated signaling (GO:0019934)4.63125636
11motile cilium assembly (GO:0044458)4.62267005
12acrosome reaction (GO:0007340)4.61495943
13regulation of autophagic vacuole assembly (GO:2000785)4.59363500
14positive regulation of catecholamine secretion (GO:0033605)4.52315818
15membrane repolarization (GO:0086009)4.51866014
16pyrimidine nucleobase catabolic process (GO:0006208)4.44238441
17potassium ion import (GO:0010107)4.30384148
18activation of protein kinase B activity (GO:0032148)4.29700620
19regulation of vacuole organization (GO:0044088)4.27251492
20radial glial cell differentiation (GO:0060019)4.18782567
21regulation of phosphoprotein phosphatase activity (GO:0043666)4.16899200
22cilium or flagellum-dependent cell motility (GO:0001539)4.10579990
23intraciliary transport (GO:0042073)4.07551886
24regulation of oxidative stress-induced neuron death (GO:1903203)4.04741672
25relaxation of smooth muscle (GO:0044557)4.03913502
26spermatid development (GO:0007286)3.96198362
27male meiosis (GO:0007140)3.82891579
28multicellular organism reproduction (GO:0032504)3.81230126
29sperm motility (GO:0030317)3.62614452
30axon extension involved in axon guidance (GO:0048846)3.61404205
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.61404205
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60182613
33hormone catabolic process (GO:0042447)3.58829403
34presynaptic membrane assembly (GO:0097105)3.58796878
35negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.54955281
36peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.54153274
37mRNA cleavage (GO:0006379)3.52198173
38negative regulation of multicellular organism growth (GO:0040015)3.49448613
39phenol-containing compound catabolic process (GO:0019336)3.47032999
40negative regulation of oligodendrocyte differentiation (GO:0048715)3.45385479
41cilium morphogenesis (GO:0060271)3.43003291
42axoneme assembly (GO:0035082)3.40931099
43negative regulation of DNA binding (GO:0043392)3.40777117
44nucleobase catabolic process (GO:0046113)3.38922021
45oligosaccharide biosynthetic process (GO:0009312)3.36895454
46regulation of phospholipase A2 activity (GO:0032429)3.36333798
47ventricular system development (GO:0021591)3.31315666
48smoothened signaling pathway (GO:0007224)3.30598768
49organic cation transport (GO:0015695)3.29760304
50neuron fate determination (GO:0048664)3.26460777
51postsynaptic membrane organization (GO:0001941)3.22605721
52gamma-aminobutyric acid transport (GO:0015812)3.19728312
53limb bud formation (GO:0060174)3.18020065
54diacylglycerol metabolic process (GO:0046339)3.16902056
55binding of sperm to zona pellucida (GO:0007339)3.12921165
56negative regulation of telomere maintenance (GO:0032205)3.05053130
57presynaptic membrane organization (GO:0097090)3.02511431
58mitochondrion degradation (GO:0000422)3.01331013
59cilium organization (GO:0044782)2.99741444
60regulation of hydrogen peroxide-induced cell death (GO:1903205)2.97985430
61neuron cell-cell adhesion (GO:0007158)2.97553360
62single fertilization (GO:0007338)2.96536947
63cilium assembly (GO:0042384)2.93727352
64regulation of secondary heart field cardioblast proliferation (GO:0003266)2.86792242
65regulation of cardioblast proliferation (GO:0003264)2.86792242
66sulfation (GO:0051923)2.86757266
67otic vesicle formation (GO:0030916)2.85851777
68behavioral response to nicotine (GO:0035095)2.84830389
69regulation of feeding behavior (GO:0060259)2.82405015
70glutamine family amino acid catabolic process (GO:0009065)2.80625259
71regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79441911
72negative regulation of stem cell proliferation (GO:2000647)2.77085437
73regulation of hydrogen peroxide metabolic process (GO:0010310)2.68848373
74regulation of membrane repolarization (GO:0060306)2.66811758
75mesenchymal-epithelial cell signaling (GO:0060638)2.62807368
76somite development (GO:0061053)2.62054265
77positive regulation of protein kinase C signaling (GO:0090037)2.61884616
78axon ensheathment in central nervous system (GO:0032291)2.61372089
79central nervous system myelination (GO:0022010)2.61372089
80sex differentiation (GO:0007548)2.60601635
81ADP metabolic process (GO:0046031)2.57482302
82negative regulation of epidermal cell differentiation (GO:0045605)2.56196311
83telencephalon development (GO:0021537)2.55204711
84thyroid gland development (GO:0030878)2.54449938
85serine family amino acid catabolic process (GO:0009071)2.53911098
86synapsis (GO:0007129)2.53741186
87regulation of acyl-CoA biosynthetic process (GO:0050812)2.53491732
88response to nitrosative stress (GO:0051409)2.52391154
89vocalization behavior (GO:0071625)2.52162466
90DNA double-strand break processing (GO:0000729)2.51714390
91neuronal stem cell maintenance (GO:0097150)2.51550597
92negative regulation of striated muscle cell apoptotic process (GO:0010664)2.50823172
93sperm-egg recognition (GO:0035036)2.49776096
94reproduction (GO:0000003)2.49491031
95regulation of dopamine secretion (GO:0014059)2.48310364
96regulation of potassium ion transmembrane transport (GO:1901379)2.47536699
97neural crest cell development (GO:0014032)2.47526058
98cochlea development (GO:0090102)2.46361624
99paraxial mesoderm development (GO:0048339)2.46324401
100cellular modified amino acid catabolic process (GO:0042219)2.46299557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.86018218
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.58924043
3IGF1R_20145208_ChIP-Seq_DFB_Human4.25415381
4GBX2_23144817_ChIP-Seq_PC3_Human4.05403643
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.89455635
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.47935583
7EZH2_22144423_ChIP-Seq_EOC_Human3.44363737
8ZNF274_21170338_ChIP-Seq_K562_Hela2.67664771
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.57334757
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56224882
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.50430779
12AR_21572438_ChIP-Seq_LNCaP_Human2.43610879
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35772341
14VDR_22108803_ChIP-Seq_LS180_Human2.23420348
15FUS_26573619_Chip-Seq_HEK293_Human2.22362167
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05319928
17P300_19829295_ChIP-Seq_ESCs_Human2.03296444
18ER_23166858_ChIP-Seq_MCF-7_Human1.88030822
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70972720
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.70972720
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60160556
22SMAD4_21799915_ChIP-Seq_A2780_Human1.59218160
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58619080
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.57313187
25RXR_22108803_ChIP-Seq_LS180_Human1.54997464
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.53792463
27CBP_20019798_ChIP-Seq_JUKART_Human1.53595565
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53595565
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52859765
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47211138
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44670863
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.44630065
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43801470
34EWS_26573619_Chip-Seq_HEK293_Human1.43780869
35RUNX2_22187159_ChIP-Seq_PCA_Human1.41666916
36KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40980203
37BCAT_22108803_ChIP-Seq_LS180_Human1.37865557
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37683809
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37567161
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34684572
41AR_25329375_ChIP-Seq_VCAP_Human1.33917130
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33792055
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33745435
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33283166
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32681754
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32137164
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.29644769
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28127371
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27969875
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25233594
51TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23963116
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.23945764
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.23776167
54STAT3_23295773_ChIP-Seq_U87_Human1.21713524
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20673833
56TP53_18474530_ChIP-ChIP_U2OS_Human1.19936110
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.18297614
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17616742
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.15742238
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14662423
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14542113
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13652363
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13330724
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12702910
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12702910
66TCF4_23295773_ChIP-Seq_U87_Human1.12519154
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12107061
68ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11887357
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11359284
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.10417664
71AHR_22903824_ChIP-Seq_MCF-7_Human1.10177795
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.09948987
73NANOG_20526341_ChIP-Seq_ESCs_Human1.09672636
74TCF4_22108803_ChIP-Seq_LS180_Human1.08855168
75TBL1_22424771_ChIP-Seq_293T_Human1.08550076
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07577665
77ERA_21632823_ChIP-Seq_H3396_Human1.07471085
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.07206529
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.06895420
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06859389
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06644933
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05682006
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05229933
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03773018
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01927466
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01175298
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00890042
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99629169
89REST_18959480_ChIP-ChIP_MESCs_Mouse0.98936616
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98933623
91CBP_21632823_ChIP-Seq_H3396_Human0.97833902
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97831854
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96690111
94REST_21632747_ChIP-Seq_MESCs_Mouse0.95825037
95RNF2_27304074_Chip-Seq_NSC_Mouse0.93867597
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92373185
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.92293384
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91633207
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91531687
100RAC3_21632823_ChIP-Seq_H3396_Human0.90731545

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.55354970
2MP0003136_yellow_coat_color4.43859231
3MP0002653_abnormal_ependyma_morphology4.18901564
4MP0003122_maternal_imprinting4.12681546
5MP0001984_abnormal_olfaction3.77077470
6MP0002928_abnormal_bile_duct2.79937292
7MP0003315_abnormal_perineum_morphology2.73844100
8MP0005410_abnormal_fertilization2.56852941
9MP0002102_abnormal_ear_morphology2.49984828
10MP0002638_abnormal_pupillary_reflex2.48759185
11MP0005499_abnormal_olfactory_system2.13768130
12MP0005394_taste/olfaction_phenotype2.13768130
13MP0006072_abnormal_retinal_apoptosis1.98518847
14MP0005084_abnormal_gallbladder_morpholo1.94682806
15MP0002132_abnormal_respiratory_system1.90500085
16MP0001270_distended_abdomen1.89152142
17MP0000049_abnormal_middle_ear1.84527620
18MP0004272_abnormal_basement_membrane1.78094540
19MP0005253_abnormal_eye_physiology1.77086400
20MP0002160_abnormal_reproductive_system1.73414094
21MP0008789_abnormal_olfactory_epithelium1.63000777
22MP0010386_abnormal_urinary_bladder1.62204258
23MP0001664_abnormal_digestion1.60740421
24MP0004859_abnormal_synaptic_plasticity1.58806501
25MP0001529_abnormal_vocalization1.57875809
26MP0002233_abnormal_nose_morphology1.47888719
27MP0002249_abnormal_larynx_morphology1.46095473
28MP0004858_abnormal_nervous_system1.45774908
29MP0010368_abnormal_lymphatic_system1.44204790
30MP0005248_abnormal_Harderian_gland1.43410077
31MP0001968_abnormal_touch/_nociception1.41789180
32MP0004133_heterotaxia1.39544557
33MP0003698_abnormal_male_reproductive1.38665215
34MP0002736_abnormal_nociception_after1.36111728
35MP0004084_abnormal_cardiac_muscle1.33103724
36MP0003938_abnormal_ear_development1.31903779
37MP0003880_abnormal_central_pattern1.30373223
38MP0003121_genomic_imprinting1.25562270
39MP0001929_abnormal_gametogenesis1.23796273
40MP0005423_abnormal_somatic_nervous1.22118272
41MP0001188_hyperpigmentation1.22104672
42MP0002127_abnormal_cardiovascular_syste1.21549007
43MP0000778_abnormal_nervous_system1.20199627
44MP0001502_abnormal_circadian_rhythm1.19736011
45MP0009046_muscle_twitch1.19019955
46MP0006276_abnormal_autonomic_nervous1.18701447
47MP0010030_abnormal_orbit_morphology1.18583581
48MP0001501_abnormal_sleep_pattern1.16935264
49MP0005187_abnormal_penis_morphology1.15457512
50MP0000631_abnormal_neuroendocrine_gland1.14395527
51MP0002272_abnormal_nervous_system1.12620968
52MP0009697_abnormal_copulation1.12106808
53MP0002234_abnormal_pharynx_morphology1.10386875
54MP0003635_abnormal_synaptic_transmissio1.10302995
55MP0000026_abnormal_inner_ear1.08446491
56MP0005646_abnormal_pituitary_gland1.07445703
57MP0005551_abnormal_eye_electrophysiolog1.06808595
58MP0000537_abnormal_urethra_morphology1.06344059
59MP0005391_vision/eye_phenotype1.04840146
60MP0002752_abnormal_somatic_nervous1.00625272
61MP0003755_abnormal_palate_morphology0.99082788
62MP0001486_abnormal_startle_reflex0.97781177
63MP0003385_abnormal_body_wall0.96890229
64MP0009250_abnormal_appendicular_skeleto0.96071573
65MP0005595_abnormal_vascular_smooth0.94420338
66MP0002572_abnormal_emotion/affect_behav0.94214206
67MP0009745_abnormal_behavioral_response0.90937472
68MP0001756_abnormal_urination0.89449857
69MP0008995_early_reproductive_senescence0.88668769
70MP0004043_abnormal_pH_regulation0.88637108
71MP0002210_abnormal_sex_determination0.87636141
72MP0003632_abnormal_nervous_system0.87572383
73MP0002064_seizures0.85314646
74MP0000538_abnormal_urinary_bladder0.84688141
75MP0001970_abnormal_pain_threshold0.84320636
76MP0001286_abnormal_eye_development0.84271508
77MP0000750_abnormal_muscle_regeneration0.84165660
78MP0002282_abnormal_trachea_morphology0.84031318
79MP0006292_abnormal_olfactory_placode0.83615918
80MP0004215_abnormal_myocardial_fiber0.83150388
81MP0001963_abnormal_hearing_physiology0.81467393
82MP0001905_abnormal_dopamine_level0.80427060
83MP0002184_abnormal_innervation0.79219930
84MP0005389_reproductive_system_phenotype0.77726232
85MP0001145_abnormal_male_reproductive0.76818612
86MP0003937_abnormal_limbs/digits/tail_de0.76480513
87MP0002735_abnormal_chemical_nociception0.75565713
88MP0003890_abnormal_embryonic-extraembry0.74795490
89MP0002882_abnormal_neuron_morphology0.74724552
90MP0002063_abnormal_learning/memory/cond0.74682354
91MP0005195_abnormal_posterior_eye0.74120315
92MP0002116_abnormal_craniofacial_bone0.73526907
93MP0000955_abnormal_spinal_cord0.73481328
94MP0004811_abnormal_neuron_physiology0.72468616
95MP0001485_abnormal_pinna_reflex0.70751096
96MP0003633_abnormal_nervous_system0.70578298
97MP0002108_abnormal_muscle_morphology0.69764015
98MP0002734_abnormal_mechanical_nocicepti0.69402548
99MP0004264_abnormal_extraembryonic_tissu0.68025342
100MP0005620_abnormal_muscle_contractility0.67444964

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)5.59755269
2Type II lissencephaly (HP:0007260)5.46513715
3Abnormal ciliary motility (HP:0012262)5.05441426
4Retinal dysplasia (HP:0007973)4.82287438
5Pancreatic fibrosis (HP:0100732)4.49176944
6Abnormal respiratory motile cilium physiology (HP:0012261)4.40736254
7True hermaphroditism (HP:0010459)4.34428337
8Pancreatic cysts (HP:0001737)4.26532490
9Abnormal respiratory motile cilium morphology (HP:0005938)4.12376530
10Abnormal respiratory epithelium morphology (HP:0012253)4.12376530
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.02317645
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.99879709
13Absent/shortened dynein arms (HP:0200106)3.99879709
14Abnormality of the columella (HP:0009929)3.75621005
15Ventricular fibrillation (HP:0001663)3.72974834
16Cystic liver disease (HP:0006706)3.54817673
17Occipital encephalocele (HP:0002085)3.45153496
18Abnormal biliary tract physiology (HP:0012439)3.32139893
19Bile duct proliferation (HP:0001408)3.32139893
20Facial hemangioma (HP:0000329)3.30336646
21Male pseudohermaphroditism (HP:0000037)3.23093224
22Molar tooth sign on MRI (HP:0002419)3.03819758
23Abnormality of midbrain morphology (HP:0002418)3.03819758
24Reduced antithrombin III activity (HP:0001976)2.98917949
25Rhinitis (HP:0012384)2.93678679
26Resting tremor (HP:0002322)2.91033401
27Retinal atrophy (HP:0001105)2.90864404
28Renal dysplasia (HP:0000110)2.85721712
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77389590
30Aplasia/hypoplasia of the uterus (HP:0008684)2.74294912
31Hypoplasia of the uterus (HP:0000013)2.73334000
32Aortic aneurysm (HP:0004942)2.64186965
33Abnormal drinking behavior (HP:0030082)2.61741305
34Polydipsia (HP:0001959)2.61741305
35Median cleft lip (HP:0000161)2.58571975
36Tubular atrophy (HP:0000092)2.58459209
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.57572927
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54060638
39Increased circulating renin level (HP:0000848)2.53911704
40Abnormal sex determination (HP:0012244)2.52524057
41Sex reversal (HP:0012245)2.52524057
42Anterior segment dysgenesis (HP:0007700)2.46894723
43Polyuria (HP:0000103)2.37914923
44Abnormality of DNA repair (HP:0003254)2.37209362
45Abnormal rod and cone electroretinograms (HP:0008323)2.36997904
46Syncope (HP:0001279)2.36328326
47Sclerocornea (HP:0000647)2.35907934
48Vitreoretinal degeneration (HP:0000655)2.34832233
49Poor coordination (HP:0002370)2.34327546
50Abnormality of the renal medulla (HP:0100957)2.34239207
51High anterior hairline (HP:0009890)2.32367065
52Nephrogenic diabetes insipidus (HP:0009806)2.31748535
53Postaxial hand polydactyly (HP:0001162)2.30628553
54Nephronophthisis (HP:0000090)2.28750500
55Medial flaring of the eyebrow (HP:0010747)2.27576807
56Chronic sinusitis (HP:0011109)2.27360343
57Gastrointestinal atresia (HP:0002589)2.26386477
58Congenital primary aphakia (HP:0007707)2.24702739
59Gait imbalance (HP:0002141)2.23754653
60Chronic hepatic failure (HP:0100626)2.22069090
61Exercise-induced muscle cramps (HP:0003710)2.20414939
62Abnormality of the frontal sinuses (HP:0002687)2.19772815
63Broad alveolar ridges (HP:0000187)2.19599758
64Atonic seizures (HP:0010819)2.18754942
65Lissencephaly (HP:0001339)2.17394431
66Postaxial foot polydactyly (HP:0001830)2.16609993
67Anencephaly (HP:0002323)2.13854847
68Gonadal dysgenesis (HP:0000133)2.08132063
69Metabolic alkalosis (HP:0200114)2.07787271
70Thyroid-stimulating hormone excess (HP:0002925)2.06662895
71Abnormality of the aortic arch (HP:0012303)2.02799724
72Abnormality of the vitreous humor (HP:0004327)2.02067485
73Thoracic kyphosis (HP:0002942)2.01690466
74Abnormality of the ileum (HP:0001549)2.01582530
75Hypothermia (HP:0002045)1.97829663
76Absent speech (HP:0001344)1.97015765
77Preaxial foot polydactyly (HP:0001841)1.94454429
78Capillary hemangiomas (HP:0005306)1.94217139
79Genital tract atresia (HP:0001827)1.92577290
80Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92321152
81Anophthalmia (HP:0000528)1.91923619
82Abnormal urine output (HP:0012590)1.91151681
83Hyperglycinemia (HP:0002154)1.91118419
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.90624212
85Optic nerve hypoplasia (HP:0000609)1.89591875
86Infertility (HP:0000789)1.89003289
87Buphthalmos (HP:0000557)1.85235704
88Prolonged QT interval (HP:0001657)1.84838690
89Pachygyria (HP:0001302)1.81541429
90Vaginal atresia (HP:0000148)1.81137314
91Esophageal atresia (HP:0002032)1.80569752
92Spinal rigidity (HP:0003306)1.80565218
93Hyperactive renin-angiotensin system (HP:0000841)1.79340683
94Tubulointerstitial nephritis (HP:0001970)1.77546528
95Thoracolumbar scoliosis (HP:0002944)1.76763709
96Intestinal atresia (HP:0011100)1.76676337
97Postural instability (HP:0002172)1.75578174
98Sensory axonal neuropathy (HP:0003390)1.74761389
99Congenital hepatic fibrosis (HP:0002612)1.73655341
100Hypokalemic alkalosis (HP:0001949)1.72995014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.17277391
2MAPK156.31544253
3STK38L3.57312321
4MARK33.23514117
5ERN13.21483834
6NEK23.20227373
7LATS12.71703736
8MYLK2.56982602
9WNK32.47011849
10MAP2K72.34214059
11CDK32.33388315
12ZAK2.01186900
13VRK11.85771917
14PNCK1.67884269
15SGK4941.44577461
16SGK2231.44577461
17TIE11.42612109
18CDK191.37368707
19LATS21.33524090
20STK381.33083236
21DYRK21.31027162
22FRK1.29704850
23TRIM281.27523321
24BMPR1B1.26689119
25EPHB21.26550231
26MAP3K41.25847139
27DYRK31.18994459
28OBSCN1.16343138
29CSNK1G21.08935078
30AKT31.08128827
31CSNK1A1L1.07253458
32SGK21.05109402
33MAP3K131.03750037
34RPS6KA41.01934596
35CASK1.00849743
36CSNK1G31.00824846
37RPS6KA50.94029063
38WEE10.93598589
39TLK10.93401062
40MARK10.93394914
41FGFR20.90223037
42NTRK20.89024728
43CDK140.87302061
44MAP3K70.81603761
45PAK20.80500308
46CSNK1G10.79422197
47MAPKAPK30.71162357
48OXSR10.70769042
49MAPK130.69439238
50FGR0.67461615
51BCR0.66716757
52GRK10.65869004
53NTRK30.65638162
54DAPK30.63041021
55CAMK10.59679560
56INSRR0.54714011
57TGFBR10.52608229
58MOS0.51498821
59RET0.47904103
60CDK50.47058864
61MAP3K20.46461655
62CDK11A0.46437553
63CDK180.46353612
64CDK150.45866855
65RPS6KB10.45137322
66ADRBK20.44307516
67EIF2AK30.43967384
68PTK2B0.42564087
69SGK30.42436650
70SRPK10.40794958
71EGFR0.40751151
72CDC42BPA0.37971290
73PRKCQ0.37418890
74MINK10.35306973
75AKT20.34657921
76PIK3CA0.33916192
77PDK20.32483302
78MARK20.32314841
79IRAK20.31341511
80MAPKAPK50.30619749
81ROCK10.30297516
82GRK50.29524790
83PRKCG0.28522598
84MKNK20.27273732
85MKNK10.26004123
86PRKG20.25709182
87MELK0.25630240
88CSNK1A10.25394094
89EPHA40.23328585
90CAMK40.22132244
91MAP3K90.21184813
92SIK30.19750698
93CAMK2B0.18682526
94MAP3K50.17854467
95TNK20.17492866
96CSNK1D0.17229774
97ATM0.16464670
98SIK20.16328287
99PRKACA0.15160677
100MAP4K20.15041604

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.72003692
2Butanoate metabolism_Homo sapiens_hsa006503.14201510
3Nitrogen metabolism_Homo sapiens_hsa009102.92730018
4Hedgehog signaling pathway_Homo sapiens_hsa043402.84044380
5Olfactory transduction_Homo sapiens_hsa047402.79491045
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.74264810
7Gap junction_Homo sapiens_hsa045402.68241390
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24752344
9Propanoate metabolism_Homo sapiens_hsa006402.22006578
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00298474
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97815830
12Chemical carcinogenesis_Homo sapiens_hsa052041.95061013
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81055289
14Steroid biosynthesis_Homo sapiens_hsa001001.78311065
15beta-Alanine metabolism_Homo sapiens_hsa004101.77066238
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65853101
17Taste transduction_Homo sapiens_hsa047421.58253639
18Arginine biosynthesis_Homo sapiens_hsa002201.52020166
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50446752
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50105295
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48710149
22Circadian entrainment_Homo sapiens_hsa047131.44469555
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44345209
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.39466301
25Circadian rhythm_Homo sapiens_hsa047101.37159183
26Glutathione metabolism_Homo sapiens_hsa004801.35478901
27Cocaine addiction_Homo sapiens_hsa050301.34960059
28Renin secretion_Homo sapiens_hsa049241.31899177
29Glycerolipid metabolism_Homo sapiens_hsa005611.28485298
30GABAergic synapse_Homo sapiens_hsa047271.26460095
31Gastric acid secretion_Homo sapiens_hsa049711.26143358
32Fanconi anemia pathway_Homo sapiens_hsa034601.24657820
33Vascular smooth muscle contraction_Homo sapiens_hsa042701.21167305
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19431373
35Alcoholism_Homo sapiens_hsa050341.17296630
36RNA degradation_Homo sapiens_hsa030181.15783764
37Peroxisome_Homo sapiens_hsa041461.15220146
38Phenylalanine metabolism_Homo sapiens_hsa003601.13414059
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12235068
40Histidine metabolism_Homo sapiens_hsa003401.09138614
41Axon guidance_Homo sapiens_hsa043601.07978323
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01237179
43Regulation of autophagy_Homo sapiens_hsa041401.00428556
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98012944
45Oxytocin signaling pathway_Homo sapiens_hsa049210.93810202
46Fatty acid degradation_Homo sapiens_hsa000710.85743138
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85088257
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84455486
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83986334
50Glutamatergic synapse_Homo sapiens_hsa047240.82068176
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79099474
52Nicotine addiction_Homo sapiens_hsa050330.78119880
53Phototransduction_Homo sapiens_hsa047440.77519809
54Phagosome_Homo sapiens_hsa041450.77206468
55Systemic lupus erythematosus_Homo sapiens_hsa053220.77016446
56PPAR signaling pathway_Homo sapiens_hsa033200.76254589
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75709937
58Dilated cardiomyopathy_Homo sapiens_hsa054140.73671123
59Salivary secretion_Homo sapiens_hsa049700.73254211
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72254055
61Apoptosis_Homo sapiens_hsa042100.71990063
62Amphetamine addiction_Homo sapiens_hsa050310.70362617
63Choline metabolism in cancer_Homo sapiens_hsa052310.69832682
64Melanoma_Homo sapiens_hsa052180.67353618
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.66032728
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65253127
67Pyruvate metabolism_Homo sapiens_hsa006200.64966693
68Retinol metabolism_Homo sapiens_hsa008300.64677210
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64079783
70Insulin secretion_Homo sapiens_hsa049110.63444561
71Dopaminergic synapse_Homo sapiens_hsa047280.60857336
72Basal cell carcinoma_Homo sapiens_hsa052170.60185556
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57975151
74Morphine addiction_Homo sapiens_hsa050320.57424823
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57371313
76Tyrosine metabolism_Homo sapiens_hsa003500.57298383
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56086212
78Oocyte meiosis_Homo sapiens_hsa041140.55608422
79Hippo signaling pathway_Homo sapiens_hsa043900.55303599
80cAMP signaling pathway_Homo sapiens_hsa040240.54918834
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.53919092
82Tryptophan metabolism_Homo sapiens_hsa003800.53047809
83Mineral absorption_Homo sapiens_hsa049780.51972950
84Calcium signaling pathway_Homo sapiens_hsa040200.51462164
85Selenocompound metabolism_Homo sapiens_hsa004500.51240555
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50818523
87Glucagon signaling pathway_Homo sapiens_hsa049220.49352161
88Fatty acid biosynthesis_Homo sapiens_hsa000610.48983377
89Dorso-ventral axis formation_Homo sapiens_hsa043200.48409314
90Wnt signaling pathway_Homo sapiens_hsa043100.47300031
91AMPK signaling pathway_Homo sapiens_hsa041520.44055802
92Cholinergic synapse_Homo sapiens_hsa047250.42674006
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.41645105
94Purine metabolism_Homo sapiens_hsa002300.41356191
95Metabolic pathways_Homo sapiens_hsa011000.40514775
96Estrogen signaling pathway_Homo sapiens_hsa049150.39771899
97TGF-beta signaling pathway_Homo sapiens_hsa043500.38689309
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38604473
99Arachidonic acid metabolism_Homo sapiens_hsa005900.37685684
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.36725361

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