DEFB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.89561310
2urate metabolic process (GO:0046415)6.02463087
3regulation of protein activation cascade (GO:2000257)5.95328549
4aminoglycoside antibiotic metabolic process (GO:0030647)5.87654892
5fibrinolysis (GO:0042730)5.77720181
6urea metabolic process (GO:0019627)5.77340858
7regulation of fibrinolysis (GO:0051917)5.66212332
8complement activation, alternative pathway (GO:0006957)5.64577389
9regulation of complement activation (GO:0030449)5.54746987
10drug transport (GO:0015893)5.50358927
11negative regulation of fibrinolysis (GO:0051918)5.40419587
12urea cycle (GO:0000050)5.39163582
13cellular glucuronidation (GO:0052695)5.38205761
14sphingoid metabolic process (GO:0046519)5.36395971
15COPI coating of Golgi vesicle (GO:0048205)5.33454566
16Golgi transport vesicle coating (GO:0048200)5.33454566
17nitrogen cycle metabolic process (GO:0071941)5.25643964
18uronic acid metabolic process (GO:0006063)5.17551690
19glucuronate metabolic process (GO:0019585)5.17551690
20peptidyl-glutamic acid carboxylation (GO:0017187)5.17332314
21protein carboxylation (GO:0018214)5.17332314
22regulation of triglyceride catabolic process (GO:0010896)5.00043950
23phenylpropanoid metabolic process (GO:0009698)4.99973784
24negative regulation of cholesterol transport (GO:0032375)4.99956717
25negative regulation of sterol transport (GO:0032372)4.99956717
26epoxygenase P450 pathway (GO:0019373)4.97985980
27lysine metabolic process (GO:0006553)4.87064697
28lysine catabolic process (GO:0006554)4.87064697
29valine metabolic process (GO:0006573)4.86041269
30organic cation transport (GO:0015695)4.82390568
31beta-amyloid metabolic process (GO:0050435)4.80438381
32desmosome organization (GO:0002934)4.68417211
33excretion (GO:0007588)4.64981342
34blood coagulation, intrinsic pathway (GO:0007597)4.60113917
35phosphate ion transport (GO:0006817)4.58071400
36phospholipid efflux (GO:0033700)4.56265315
37regulation of cholesterol esterification (GO:0010872)4.53730073
38bile acid biosynthetic process (GO:0006699)4.52611847
39negative regulation of coagulation (GO:0050819)4.47103890
40negative regulation of blood coagulation (GO:0030195)4.43270415
41negative regulation of hemostasis (GO:1900047)4.43270415
42renal absorption (GO:0070293)4.40055501
43response to mercury ion (GO:0046689)4.39126612
44negative regulation of protein activation cascade (GO:2000258)4.38873393
45peptide catabolic process (GO:0043171)4.38033300
46drug metabolic process (GO:0017144)4.37900227
47acute-phase response (GO:0006953)4.35225503
48oxidative demethylation (GO:0070989)4.34552708
49negative regulation of complement activation (GO:0045916)4.33677828
50serine family amino acid catabolic process (GO:0009071)4.32856990
51tricarboxylic acid metabolic process (GO:0072350)4.29211083
52diol metabolic process (GO:0034311)4.24543055
53bile acid metabolic process (GO:0008206)4.23126463
54alkaloid metabolic process (GO:0009820)4.21418479
55sphingosine metabolic process (GO:0006670)4.18290757
56ethanol oxidation (GO:0006069)4.16105944
57response to phenylpropanoid (GO:0080184)4.13862963
58omega-hydroxylase P450 pathway (GO:0097267)4.12968505
59negative regulation of wound healing (GO:0061045)4.12396410
60branched-chain amino acid metabolic process (GO:0009081)4.09654471
61regulation of bile acid biosynthetic process (GO:0070857)4.09527821
62maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.06015398
63glycoside metabolic process (GO:0016137)4.04579071
64acylglycerol homeostasis (GO:0055090)4.01563018
65triglyceride homeostasis (GO:0070328)4.01563018
66short-chain fatty acid metabolic process (GO:0046459)3.99318178
67quaternary ammonium group transport (GO:0015697)3.97332348
68regulation of plasminogen activation (GO:0010755)3.95655116
69glyoxylate metabolic process (GO:0046487)3.93087777
70cysteine metabolic process (GO:0006534)3.89746876
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81838079
72protein activation cascade (GO:0072376)3.78211910
73bile acid and bile salt transport (GO:0015721)3.78159218
74intestinal cholesterol absorption (GO:0030299)3.76536321
75polyol transport (GO:0015791)3.75249429
76regulation of water loss via skin (GO:0033561)3.74229795
77macromolecular complex remodeling (GO:0034367)3.73569227
78plasma lipoprotein particle remodeling (GO:0034369)3.73569227
79protein-lipid complex remodeling (GO:0034368)3.73569227
80high-density lipoprotein particle remodeling (GO:0034375)3.70332264
81negative regulation of lipase activity (GO:0060192)3.68539598
82* acute inflammatory response (GO:0002526)3.67914496
83primary alcohol catabolic process (GO:0034310)3.66371838
84ethanol metabolic process (GO:0006067)3.65899836
85L-phenylalanine catabolic process (GO:0006559)3.65643309
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65643309
87cellular response to vitamin D (GO:0071305)3.63767968
88arginine metabolic process (GO:0006525)3.62890225
89L-phenylalanine metabolic process (GO:0006558)3.61782858
90erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61782858
91regulation of humoral immune response (GO:0002920)3.61696740
92cellular modified amino acid catabolic process (GO:0042219)3.61114142
93hormone catabolic process (GO:0042447)3.61093845
94complement activation (GO:0006956)3.58295061
95protein retention in ER lumen (GO:0006621)3.57086041
96COPII vesicle coating (GO:0048208)3.55723367
97multicellular organismal water homeostasis (GO:0050891)3.54882668
98establishment of skin barrier (GO:0061436)3.54369080
99retinal metabolic process (GO:0042574)3.53625898
100transepithelial transport (GO:0070633)3.52058867
101metanephric nephron tubule development (GO:0072234)3.51203025
102metanephric tubule development (GO:0072170)3.51203025
103complement activation, classical pathway (GO:0006958)3.50385060
104flavonoid metabolic process (GO:0009812)3.49747654
105glycine metabolic process (GO:0006544)3.48946063
106negative regulation of humoral immune response (GO:0002921)3.46634720
107phosphate ion transmembrane transport (GO:0035435)3.46202859
108branched-chain amino acid catabolic process (GO:0009083)3.45267895
109drug catabolic process (GO:0042737)3.43788666
110homocysteine metabolic process (GO:0050667)3.42900336
111positive regulation of lipoprotein lipase activity (GO:0051006)3.41926748
112positive regulation of triglyceride lipase activity (GO:0061365)3.41926748
113polyketide metabolic process (GO:0030638)3.38615620
114doxorubicin metabolic process (GO:0044598)3.38615620
115daunorubicin metabolic process (GO:0044597)3.38615620
116regulation of lipoprotein particle clearance (GO:0010984)3.38154136
117cholesterol efflux (GO:0033344)3.36562362
118fatty acid beta-oxidation (GO:0006635)3.33786462
119plasma lipoprotein particle clearance (GO:0034381)3.32086004
120peptide hormone processing (GO:0016486)3.30373791
121aspartate family amino acid catabolic process (GO:0009068)3.28503244
122positive regulation of blood coagulation (GO:0030194)3.28416999
123positive regulation of hemostasis (GO:1900048)3.28416999
124endocrine pancreas development (GO:0031018)3.27604845
125steroid catabolic process (GO:0006706)3.27560019
1262-oxoglutarate metabolic process (GO:0006103)3.25949747
127UDP-N-acetylglucosamine metabolic process (GO:0006047)3.25293131
128serine family amino acid metabolic process (GO:0009069)3.24879691
129intestinal epithelial cell development (GO:0060576)3.22898807
130retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20258409
131sulfur amino acid catabolic process (GO:0000098)3.19293720
132metanephric nephron epithelium development (GO:0072243)3.18860688
133vitamin D metabolic process (GO:0042359)3.18189335
134reverse cholesterol transport (GO:0043691)3.17424971
135tyrosine metabolic process (GO:0006570)3.16869436
136nonribosomal peptide biosynthetic process (GO:0019184)3.16847798
137toxin transport (GO:1901998)3.16713706
138fatty acid oxidation (GO:0019395)3.14958081
139serine family amino acid biosynthetic process (GO:0009070)3.12037038
140exogenous drug catabolic process (GO:0042738)3.11814372
141phospholipid scrambling (GO:0017121)3.09126740
142primary alcohol metabolic process (GO:0034308)3.08654180
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.08640283
144aromatic amino acid family catabolic process (GO:0009074)3.08095985
145ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.07999547
146lipid oxidation (GO:0034440)3.07674215
147glandular epithelial cell differentiation (GO:0002067)3.05797047
148pyrimidine ribonucleoside catabolic process (GO:0046133)3.04778403
149positive regulation of coagulation (GO:0050820)3.04647595
150fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03703955
151water homeostasis (GO:0030104)3.02879190
152positive regulation of lipid catabolic process (GO:0050996)3.02862302
153calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.02850171
154diterpenoid biosynthetic process (GO:0016102)3.02640713
155fructose metabolic process (GO:0006000)3.02275899
156positive regulation of fatty acid biosynthetic process (GO:0045723)3.01646342
157proline metabolic process (GO:0006560)2.99737802
158positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.97232892
159positive regulation of extracellular matrix organization (GO:1903055)2.96359325
160fucose metabolic process (GO:0006004)2.95501584
161phosphate ion homeostasis (GO:0055062)2.93024301
162trivalent inorganic anion homeostasis (GO:0072506)2.93024301
163cellular ketone body metabolic process (GO:0046950)2.89837911
164metanephric epithelium development (GO:0072207)2.89357211
1654-hydroxyproline metabolic process (GO:0019471)2.89034299
166cellular response to vitamin (GO:0071295)2.88973081
167glutathione biosynthetic process (GO:0006750)2.88036198
168positive regulation of nuclease activity (GO:0032075)2.87540580
169regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.85620059
170carnitine transport (GO:0015879)2.85349267
171amino-acid betaine transport (GO:0015838)2.85349267
172tryptophan metabolic process (GO:0006568)2.85140653
173nephron tubule development (GO:0072080)2.84149824
174fatty acid catabolic process (GO:0009062)2.83158881
175transcytosis (GO:0045056)2.80702583
176angiotensin maturation (GO:0002003)2.80015169
177regulation of ruffle assembly (GO:1900027)2.77135373
178regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75869590
179modified amino acid transport (GO:0072337)2.74992793
180amino-acid betaine metabolic process (GO:0006577)2.74458035
181activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.70696969
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.70112439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.21915936
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.04488667
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.52263595
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52043484
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.41224822
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.37105695
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.97513435
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.76105865
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.71997865
10GATA1_22025678_ChIP-Seq_K562_Human2.57298148
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.46476902
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29091741
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13412415
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.13250640
15* SOX2_20726797_ChIP-Seq_SW620_Human2.06811603
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06082224
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.04028021
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99133211
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.96401326
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96233749
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.93221240
22CLOCK_20551151_ChIP-Seq_293T_Human1.92804874
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90998531
24GATA4_25053715_ChIP-Seq_YYC3_Human1.88802472
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88543153
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.73147510
27AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.67168135
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65612650
29P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59022836
30GATA3_24758297_ChIP-Seq_MCF-7_Human1.58015236
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57762200
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.55241965
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.49168077
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48743449
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44517466
36GATA6_25053715_ChIP-Seq_YYC3_Human1.44227664
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41565046
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40509279
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37553783
40* TP63_23658742_ChIP-Seq_EP156T_Human1.37470055
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37372983
42* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35579213
43AHR_22903824_ChIP-Seq_MCF-7_Human1.34764234
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.31391635
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.29429519
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.29052219
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28064224
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27295882
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.26345990
50FOXA1_25552417_ChIP-Seq_VCAP_Human1.24061602
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16618102
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16618102
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13834003
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13725248
55RXR_22108803_ChIP-Seq_LS180_Human1.11261579
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11065648
57CJUN_26792858_Chip-Seq_BT549_Human1.10113338
58CDX2_22108803_ChIP-Seq_LS180_Human1.08875933
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07962233
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07202394
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06860221
62HTT_18923047_ChIP-ChIP_STHdh_Human1.05654050
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04528403
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03913214
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02399341
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.01783960
67TBX20_22080862_ChIP-Seq_HEART_Mouse1.01783960
68ESR1_20079471_ChIP-ChIP_T-47D_Human0.99550115
69TCF4_22108803_ChIP-Seq_LS180_Human0.98787008
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97923975
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97148940
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97059880
73ZNF274_21170338_ChIP-Seq_K562_Hela0.96969454
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96819362
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96819362
76BCAT_22108803_ChIP-Seq_LS180_Human0.95367878
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95205771
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94652756
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93864630
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92771314
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92507350
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91985101
83RACK7_27058665_Chip-Seq_MCF-7_Human0.91691020
84SMAD3_21741376_ChIP-Seq_HESCs_Human0.90092453
85ERG_20517297_ChIP-Seq_VCAP_Human0.88807177
86FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88127595
87HNF4A_19822575_ChIP-Seq_HepG2_Human0.86642906
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86619722
89TP53_18474530_ChIP-ChIP_U2OS_Human0.85917912
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.85568693
91EGR1_19032775_ChIP-ChIP_M12_Human0.85342453
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84982916
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84977426
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84819115
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82724079
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82213866
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81561316
98VDR_22108803_ChIP-Seq_LS180_Human0.81145912
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80402679
100RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80402618
101FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79537264
102FOXA1_25329375_ChIP-Seq_VCAP_Human0.79537264
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.78872514
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.78721680
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78169908
106ZNF263_19887448_ChIP-Seq_K562_Human0.77661855
107LXR_22292898_ChIP-Seq_THP-1_Human0.77056806
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76084527
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75959840
110EP300_21415370_ChIP-Seq_HL-1_Mouse0.75726914
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75430712
112GATA6_21074721_ChIP-Seq_CACO-2_Human0.75370850
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75186942
114AR_20517297_ChIP-Seq_VCAP_Human0.74599223
115TP63_22573176_ChIP-Seq_HFKS_Human0.74046565
116CHD1_26751641_Chip-Seq_LNCaP_Human0.73598747
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73356280
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72748787
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.71758601
120HNFA_21074721_ChIP-Seq_CACO-2_Human0.67187591
121CEBPB_22108803_ChIP-Seq_LS180_Human0.66621008
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65262143
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.64183720
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.63762176
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63311524
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.63018573
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62640034
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62498167
129VDR_24787735_ChIP-Seq_THP-1_Human0.62273071
130P53_21459846_ChIP-Seq_SAOS-2_Human0.59951596
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.59795779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.12626587
2MP0003195_calcinosis5.00036971
3MP0010234_abnormal_vibrissa_follicle4.79113424
4MP0001765_abnormal_ion_homeostasis3.62904880
5MP0005360_urolithiasis3.57062164
6MP0004019_abnormal_vitamin_homeostasis3.38159975
7MP0003868_abnormal_feces_composition3.37092869
8MP0002139_abnormal_hepatobiliary_system3.26998391
9MP0002796_impaired_skin_barrier3.25147355
10MP0009643_abnormal_urine_homeostasis3.19948982
11MP0001756_abnormal_urination2.88690743
12MP0009840_abnormal_foam_cell2.88167902
13MP0005332_abnormal_amino_acid2.77543655
14MP0005636_abnormal_mineral_homeostasis2.76969376
15MP0002138_abnormal_hepatobiliary_system2.36080812
16MP0005451_abnormal_body_composition2.35363523
17MP0009780_abnormal_chondrocyte_physiolo2.27402192
18MP0004264_abnormal_extraembryonic_tissu2.21300986
19MP0003941_abnormal_skin_development2.11190566
20MP0000538_abnormal_urinary_bladder2.10446283
21MP0003300_gastrointestinal_ulcer2.09225529
22MP0003252_abnormal_bile_duct2.04693479
23MP0002136_abnormal_kidney_physiology2.04431675
24MP0005501_abnormal_skin_physiology1.87101431
25MP0003806_abnormal_nucleotide_metabolis1.86910578
26MP0005220_abnormal_exocrine_pancreas1.82474485
27MP0002009_preneoplasia1.81142870
28MP0005365_abnormal_bile_salt1.76052504
29MP0008875_abnormal_xenobiotic_pharmacok1.75813397
30MP0008961_abnormal_basal_metabolism1.73621560
31MP0003283_abnormal_digestive_organ1.72916468
32MP0002132_abnormal_respiratory_system1.72338118
33MP0009697_abnormal_copulation1.72181435
34MP0005085_abnormal_gallbladder_physiolo1.69101787
35MP0005058_abnormal_lysosome_morphology1.66883042
36MP0004885_abnormal_endolymph1.66665227
37MP0002098_abnormal_vibrissa_morphology1.65909535
38MP0005310_abnormal_salivary_gland1.65904415
39MP0001944_abnormal_pancreas_morphology1.64522181
40MP0005275_abnormal_skin_tensile1.64506913
41MP0002877_abnormal_melanocyte_morpholog1.59284497
42MP0005084_abnormal_gallbladder_morpholo1.58949451
43MP0003183_abnormal_peptide_metabolism1.56755264
44MP0002693_abnormal_pancreas_physiology1.52606418
45MP0000566_synostosis1.47315283
46MP0000013_abnormal_adipose_tissue1.45281188
47MP0001666_abnormal_nutrient_absorption1.41684477
48MP0005083_abnormal_biliary_tract1.33240687
49MP0002876_abnormal_thyroid_physiology1.33067991
50MP0002909_abnormal_adrenal_gland1.32640130
51* MP0010386_abnormal_urinary_bladder1.30402683
52MP0002060_abnormal_skin_morphology1.25073543
53MP0002896_abnormal_bone_mineralization1.22455072
54MP0001216_abnormal_epidermal_layer1.19212124
55MP0000230_abnormal_systemic_arterial1.18045543
56MP0006072_abnormal_retinal_apoptosis1.14619092
57MP0000537_abnormal_urethra_morphology1.12442071
58MP0002837_dystrophic_cardiac_calcinosis1.09652675
59MP0002166_altered_tumor_susceptibility1.09575863
60MP0004947_skin_inflammation1.09427016
61MP0009785_altered_susceptibility_to1.09107365
62MP0002089_abnormal_postnatal_growth/wei1.07969050
63MP0000377_abnormal_hair_follicle1.07257295
64MP0010678_abnormal_skin_adnexa1.06497752
65MP0003191_abnormal_cellular_cholesterol1.06364017
66MP0002078_abnormal_glucose_homeostasis1.03665852
67MP0006054_spinal_hemorrhage1.02829303
68MP0008004_abnormal_stomach_pH1.01515320
69MP0005379_endocrine/exocrine_gland_phen1.01273343
70MP0005535_abnormal_body_temperature1.00957607
71MP0010771_integument_phenotype0.99356732
72MP0000678_abnormal_parathyroid_gland0.97214319
73MP0005023_abnormal_wound_healing0.94724008
74MP0004381_abnormal_hair_follicle0.93911849
75MP0000613_abnormal_salivary_gland0.93389232
76MP0002928_abnormal_bile_duct0.93129089
77MP0000579_abnormal_nail_morphology0.92051525
78MP0002168_other_aberrant_phenotype0.92000627
79MP0003186_abnormal_redox_activity0.89224633
80MP0005164_abnormal_response_to0.89102602
81MP0001764_abnormal_homeostasis0.87629787
82MP0002118_abnormal_lipid_homeostasis0.87038331
83MP0005666_abnormal_adipose_tissue0.85545193
84MP0003879_abnormal_hair_cell0.84051483
85MP0003724_increased_susceptibility_to0.83270264
86MP0003453_abnormal_keratinocyte_physiol0.82501681
87MP0004147_increased_porphyrin_level0.81340046
88MP0002277_abnormal_respiratory_mucosa0.81009193
89MP0005647_abnormal_sex_gland0.80985846
90MP0004272_abnormal_basement_membrane0.80109861
91MP0005319_abnormal_enzyme/_coenzyme0.79768459
92MP0001191_abnormal_skin_condition0.77035549
93MP0000598_abnormal_liver_morphology0.76155605
94MP0003172_abnormal_lysosome_physiology0.75478656
95MP0008469_abnormal_protein_level0.74652294
96MP0005375_adipose_tissue_phenotype0.73328192
97MP0005584_abnormal_enzyme/coenzyme_acti0.72093098
98MP0001346_abnormal_lacrimal_gland0.72085808
99MP0000367_abnormal_coat/_hair0.71872770
100MP0002135_abnormal_kidney_morphology0.71859969
101MP0000003_abnormal_adipose_tissue0.70665561
102MP0002254_reproductive_system_inflammat0.69838573
103MP0003953_abnormal_hormone_level0.68137576
104MP0001958_emphysema0.66590320
105MP0003943_abnormal_hepatobiliary_system0.66559400
106MP0009764_decreased_sensitivity_to0.66406051
107MP0002006_tumorigenesis0.66275549
108MP0009763_increased_sensitivity_to0.65531175
109MP0004883_abnormal_blood_vessel0.65258026
110MP0003011_delayed_dark_adaptation0.64891098
111MP0005395_other_phenotype0.64723003
112MP0001919_abnormal_reproductive_system0.64417477
113MP0003959_abnormal_lean_body0.63949898
114MP0005166_decreased_susceptibility_to0.63577556
115MP0009642_abnormal_blood_homeostasis0.63347061
116MP0005376_homeostasis/metabolism_phenot0.63106814
117MP0005408_hypopigmentation0.63037773
118MP0010329_abnormal_lipoprotein_level0.62267843
119MP0005670_abnormal_white_adipose0.62255988
120MP0002234_abnormal_pharynx_morphology0.61850771
121MP0000609_abnormal_liver_physiology0.60601623
122MP0003315_abnormal_perineum_morphology0.60333372
123MP0001845_abnormal_inflammatory_respons0.59898421
124MP0000604_amyloidosis0.58423890
125MP0003690_abnormal_glial_cell0.57853304
126MP0002971_abnormal_brown_adipose0.56979947
127MP0000249_abnormal_blood_vessel0.56914920
128MP0001881_abnormal_mammary_gland0.56442159
129MP0001873_stomach_inflammation0.55521395
130MP0008872_abnormal_physiological_respon0.55518326
131MP0003436_decreased_susceptibility_to0.54806446
132MP0000467_abnormal_esophagus_morphology0.54575956
133MP0001664_abnormal_digestion0.54354891
134MP0003638_abnormal_response/metabolism_0.54059839
135MP0002163_abnormal_gland_morphology0.52620425
136MP0004782_abnormal_surfactant_physiolog0.52357680
137* MP0005025_abnormal_response_to0.48098958
138MP0008874_decreased_physiological_sensi0.47965977
139MP0003045_fibrosis0.43754546
140MP0003950_abnormal_plasma_membrane0.43212821
141MP0001270_distended_abdomen0.40512678
142MP0002419_abnormal_innate_immunity0.40123974
143MP0001851_eye_inflammation0.39830400
144MP0000462_abnormal_digestive_system0.39730656

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.84001374
2Abnormality of monocarboxylic acid metabolism (HP:0010996)7.83729434
3Hypokalemic alkalosis (HP:0001949)7.50815696
4Increased circulating renin level (HP:0000848)7.10349098
5Hyperactive renin-angiotensin system (HP:0000841)6.79991761
6Metabolic alkalosis (HP:0200114)6.75029990
7Abnormality of chloride homeostasis (HP:0011422)6.42040602
8Hypomagnesemia (HP:0002917)6.34106535
9Prolonged partial thromboplastin time (HP:0003645)6.02941526
10Polyuria (HP:0000103)5.80318785
11Abnormal urine output (HP:0012590)5.58614264
12Complement deficiency (HP:0004431)5.55302109
13Abnormality of magnesium homeostasis (HP:0004921)5.38905765
14Systemic lupus erythematosus (HP:0002725)5.34929310
15Gout (HP:0001997)5.34883161
16Abnormality of renal excretion (HP:0011036)5.23577985
17Hypobetalipoproteinemia (HP:0003563)5.05668673
18Abnormality of renin-angiotensin system (HP:0000847)5.00548017
19Polydipsia (HP:0001959)4.83813653
20Abnormal drinking behavior (HP:0030082)4.83813653
21Hyperaldosteronism (HP:0000859)4.67582187
22Alkalosis (HP:0001948)4.61124554
23Renal salt wasting (HP:0000127)4.55905435
24Hypokalemia (HP:0002900)4.48076765
25Tetany (HP:0001281)4.45431730
26Abnormality of complement system (HP:0005339)4.36586420
27Glomerulonephritis (HP:0000099)4.16878369
28Joint hemorrhage (HP:0005261)4.09317676
29Ketoacidosis (HP:0001993)4.04832823
30Generalized aminoaciduria (HP:0002909)3.90923966
31Abnormality of pyrimidine metabolism (HP:0004353)3.86800967
32Xanthomatosis (HP:0000991)3.81320731
33Intrahepatic cholestasis (HP:0001406)3.77905813
34Hyperlipoproteinemia (HP:0010980)3.74220625
35Abnormality of potassium homeostasis (HP:0011042)3.63300277
36Proximal tubulopathy (HP:0000114)3.59400096
37Abnormality of purine metabolism (HP:0004352)3.57814810
38Increased purine levels (HP:0004368)3.54636242
39Hyperuricemia (HP:0002149)3.54636242
40Hyperglycinuria (HP:0003108)3.38948811
41Ketosis (HP:0001946)3.08851522
42Decreased circulating renin level (HP:0003351)3.00808795
43Hypolipoproteinemia (HP:0010981)3.00396404
44Nephritis (HP:0000123)2.99109019
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.97929950
46Hypoglycemic coma (HP:0001325)2.97022240
47Steatorrhea (HP:0002570)2.96107816
48Vacuolated lymphocytes (HP:0001922)2.94090569
49Mitral stenosis (HP:0001718)2.89935036
50Glycosuria (HP:0003076)2.83897342
51Abnormality of urine glucose concentration (HP:0011016)2.83897342
52Abnormality of the common coagulation pathway (HP:0010990)2.79457561
53Hypoplasia of the uterus (HP:0000013)2.75316159
54Dehydration (HP:0001944)2.74317948
55Hypercalciuria (HP:0002150)2.74258818
56Hyperammonemia (HP:0001987)2.71026524
57Reduced antithrombin III activity (HP:0001976)2.68438560
58Abnormality of glycine metabolism (HP:0010895)2.67832799
59Abnormality of serine family amino acid metabolism (HP:0010894)2.67832799
60Conjugated hyperbilirubinemia (HP:0002908)2.67409010
61Mucopolysacchariduria (HP:0008155)2.63386991
62Urinary glycosaminoglycan excretion (HP:0003541)2.63386991
63Recurrent gram-negative bacterial infections (HP:0005420)2.60091025
64Symptomatic seizures (HP:0011145)2.56791838
65Hypoglycemic seizures (HP:0002173)2.52570176
66Dysostosis multiplex (HP:0000943)2.52081004
67Abnormality of fatty-acid metabolism (HP:0004359)2.50646559
68Hyperinsulinemic hypoglycemia (HP:0000825)2.45224015
69Hyperphosphaturia (HP:0003109)2.44681599
70Hypophosphatemia (HP:0002148)2.42788383
71Hyponatremia (HP:0002902)2.42408820
72Parakeratosis (HP:0001036)2.41364749
73Abnormality of the Achilles tendon (HP:0005109)2.40935401
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40644480
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40644480
76Abnormality of polysaccharide metabolism (HP:0011012)2.40644480
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.39866014
78Hypoalphalipoproteinemia (HP:0003233)2.37923293
79Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37005228
80Adrenal overactivity (HP:0002717)2.36540853
81Late onset (HP:0003584)2.36484782
82Renal tubular acidosis (HP:0001947)2.32805872
83Abnormality of sodium homeostasis (HP:0010931)2.32585890
84Abnormality of nucleobase metabolism (HP:0010932)2.30586889
85Widely patent fontanelles and sutures (HP:0004492)2.29504752
86Abnormal urine phosphate concentration (HP:0012599)2.27697925
87Sensorimotor neuropathy (HP:0007141)2.26935219
88Gangrene (HP:0100758)2.26791792
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24128198
90Abnormality of proline metabolism (HP:0010907)2.23029685
91Hydroxyprolinuria (HP:0003080)2.23029685
92Exocrine pancreatic insufficiency (HP:0001738)2.21693220
93Rickets (HP:0002748)2.18725032
94Focal segmental glomerulosclerosis (HP:0000097)2.18630698
95Abnormal pancreas size (HP:0012094)2.15006020
96Hemorrhage of the eye (HP:0011885)2.14538929
97Aplasia/hypoplasia of the uterus (HP:0008684)2.11678961
98Abnormality of alkaline phosphatase activity (HP:0004379)2.11207240
99Nephrolithiasis (HP:0000787)2.10708791
100Abnormal enzyme/coenzyme activity (HP:0012379)2.10618431
101Vascular calcification (HP:0004934)2.10602417
102Hyperglycinemia (HP:0002154)2.09665364
103Hyperkalemia (HP:0002153)2.09337738
104Hepatocellular carcinoma (HP:0001402)2.08974659
105Hypotension (HP:0002615)2.08630898
106Protuberant abdomen (HP:0001538)2.07880397
107Erythema (HP:0010783)2.07393129
108Delayed epiphyseal ossification (HP:0002663)2.06054885
109Facial shape deformation (HP:0011334)2.05674972
110Potter facies (HP:0002009)2.05674972
111Nephrocalcinosis (HP:0000121)2.02226289
112Menorrhagia (HP:0000132)2.01617233
113Osteomalacia (HP:0002749)2.01282179
114Abnormality of serum amino acid levels (HP:0003112)2.00306396
115Abnormality of calcium-phosphate metabolism (HP:0100530)1.99280933
116Enlarged kidneys (HP:0000105)1.99085896
117Congenital ichthyosiform erythroderma (HP:0007431)1.96453696
118Ileus (HP:0002595)1.95635977
119Elevated alkaline phosphatase (HP:0003155)1.95223979
120Increased serum ferritin (HP:0003281)1.94305893
121Glomerulosclerosis (HP:0000096)1.93455300
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92850457
123Abnormal tarsal ossification (HP:0008369)1.92658610
124Spontaneous abortion (HP:0005268)1.92203523
125Hyperphosphatemia (HP:0002905)1.92066240
126Purpura (HP:0000979)1.89158797
127Increased IgE level (HP:0003212)1.88688167
128Abnormality of the intrinsic pathway (HP:0010989)1.88142030
129Chondrocalcinosis (HP:0000934)1.85769379
130Cardiovascular calcification (HP:0011915)1.84108862
131Delayed CNS myelination (HP:0002188)1.83176186
132Fat malabsorption (HP:0002630)1.82786008
133Congenital sensorineural hearing impairment (HP:0008527)1.81242032
134Cholecystitis (HP:0001082)1.80654387
135Abnormal gallbladder physiology (HP:0012438)1.80654387
136Pancreatitis (HP:0001733)1.79902858
137Hyperparathyroidism (HP:0000843)1.79819170
138Metabolic acidosis (HP:0001942)1.78864623
139Gingival bleeding (HP:0000225)1.78625332
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76924314
141Abnormality of Sharpey fibers (HP:0100685)1.75457474
142Malnutrition (HP:0004395)1.75105766
143Dicarboxylic aciduria (HP:0003215)1.74524630
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74524630
145Pulmonary embolism (HP:0002204)1.74023703
146Thin bony cortex (HP:0002753)1.73903501
147Fair hair (HP:0002286)1.73315704
148Abnormality of renal resorption (HP:0011038)1.71930398
149Vomiting (HP:0002013)1.70953470
150Hyperglycemia (HP:0003074)1.65334307

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.11087557
2OXSR16.22471284
3WNK35.27355646
4STK395.20267691
5INSRR3.21417565
6STK242.67308586
7BCKDK2.67138190
8MST42.58516510
9FRK2.57487476
10MAP3K22.35754307
11ERN12.33321187
12TAOK32.15607026
13LATS12.08744724
14MAP3K122.06915589
15STK38L1.92989790
16MST1R1.83311288
17FER1.75978083
18AKT31.73533956
19MAP3K31.53985691
20WNK11.53047246
21TNK21.52521063
22TBK11.47229763
23PRKG21.38995735
24ABL21.36440254
25PASK1.31140366
26PTK61.19289702
27MAPK151.16079159
28SGK2231.07877556
29SGK4941.07877556
30MAPKAPK31.07219640
31FGFR21.04406021
32IKBKB1.03905351
33PDK21.03212530
34MET0.98153379
35TAOK20.97586075
36TESK10.93684074
37NLK0.90699755
38HIPK20.89962943
39PIK3CG0.89616908
40EIF2AK30.89259709
41IKBKE0.87548333
42PDK40.85447038
43PDK30.85447038
44JAK10.84890372
45FLT30.83139840
46IRAK30.82970566
47TRPM70.81143255
48LRRK20.77988178
49SCYL20.77921565
50SGK20.76873152
51PRKCQ0.76254046
52SIK10.75243783
53TRIB30.74453681
54PRPF4B0.73303263
55FGFR30.72825943
56PRKD30.72557781
57SGK30.69499214
58MAPK70.68994113
59MAP3K140.67071697
60STK380.66664086
61NTRK10.63295653
62PIM20.61961526
63EPHA20.61604294
64DYRK1B0.60061983
65PDGFRB0.59558705
66ILK0.59223648
67PTK20.58603573
68PDGFRA0.57275102
69MAP2K60.56869283
70TAOK10.56151229
71FGFR10.55849782
72GSK3A0.55797096
73PRKCI0.53875867
74TYK20.52237058
75CDK80.50835068
76GRK70.50542617
77MELK0.49205954
78CHUK0.49179877
79JAK20.48894822
80TGFBR20.48581495
81FGFR40.47233519
82MAP3K10.46658006
83PAK30.44306695
84CDK60.42954378
85PRKCG0.42853324
86ITK0.41172471
87PRKG10.40822440
88GRK10.40780623
89IRAK20.40182760
90ERBB20.39823673
91MAPK120.39535206
92ZAP700.39366417
93LMTK20.39246720
94PRKAA10.37891073
95PRKCE0.37852290
96ERBB30.35883790
97KIT0.35697797
98EPHA30.35406720
99MAP3K50.34597507
100ROCK10.34310468
101PRKACA0.34275160
102EPHB10.34261519
103RIPK40.32873817
104PRKCD0.32485416
105AKT20.31609354
106MAP3K60.31465115
107PRKD20.30718380
108MAP2K20.30657411
109SGK10.29733023
110PDPK10.29242517
111BCR0.28953775
112NME10.28911051
113RIPK10.27725867
114CDC42BPA0.26369480
115MAP3K70.26323808
116NEK60.25280691
117PKN20.25241618
118TIE10.23943572
119PRKAA20.23759330
120RPS6KA20.23576213
121IRAK10.22933837
122BRD40.22900410
123MYLK0.21949043
124PRKD10.18780319
125PRKCH0.18234080
126PRKCA0.17746807
127EPHB20.17571243
128PRKACG0.17115312
129IGF1R0.17026549
130CAMKK20.16543000
131STK30.16260088
132PDK10.16087602
133PRKCZ0.14941279
134ERBB40.14556350
135PIK3CA0.14501474
136STK100.14479720
137RET0.14318724
138PINK10.14115046
139BTK0.12743440
140LIMK10.12603827
141CSNK1A10.10784875
142ADRBK10.10128523

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.23489596
2Sulfur metabolism_Homo sapiens_hsa009203.79381527
3Complement and coagulation cascades_Homo sapiens_hsa046103.70987760
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.90980835
5Butanoate metabolism_Homo sapiens_hsa006502.60862498
6Collecting duct acid secretion_Homo sapiens_hsa049662.52530490
7Propanoate metabolism_Homo sapiens_hsa006402.41445116
8Protein export_Homo sapiens_hsa030602.36082926
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.28883567
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24314944
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.14861745
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11461597
13Fatty acid degradation_Homo sapiens_hsa000712.08247825
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05590783
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03800446
16Caffeine metabolism_Homo sapiens_hsa002321.99677476
17Tryptophan metabolism_Homo sapiens_hsa003801.93189100
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.89991499
19Sphingolipid metabolism_Homo sapiens_hsa006001.82016435
20Other glycan degradation_Homo sapiens_hsa005111.80848851
21Peroxisome_Homo sapiens_hsa041461.76377630
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65745381
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.62772161
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62288454
25Vibrio cholerae infection_Homo sapiens_hsa051101.58445354
26Selenocompound metabolism_Homo sapiens_hsa004501.56111019
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54432515
28beta-Alanine metabolism_Homo sapiens_hsa004101.52003866
29Fatty acid metabolism_Homo sapiens_hsa012121.43948776
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43874888
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40613884
32Lysosome_Homo sapiens_hsa041421.38033992
33Mineral absorption_Homo sapiens_hsa049781.37147619
34Histidine metabolism_Homo sapiens_hsa003401.35883894
35Phenylalanine metabolism_Homo sapiens_hsa003601.35019093
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34312580
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34199993
38Pyruvate metabolism_Homo sapiens_hsa006201.33795917
39Renin-angiotensin system_Homo sapiens_hsa046141.29757249
40Folate biosynthesis_Homo sapiens_hsa007901.29186471
41Vitamin digestion and absorption_Homo sapiens_hsa049771.28818978
42Staphylococcus aureus infection_Homo sapiens_hsa051501.18682870
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17744376
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13747966
45Bile secretion_Homo sapiens_hsa049761.13407518
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12692279
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.08838462
48Protein digestion and absorption_Homo sapiens_hsa049741.08079752
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06215777
50Glutathione metabolism_Homo sapiens_hsa004801.02490731
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01153950
52ABC transporters_Homo sapiens_hsa020101.01129495
53Thyroid hormone synthesis_Homo sapiens_hsa049181.00955537
54Fatty acid elongation_Homo sapiens_hsa000620.99773150
55Sulfur relay system_Homo sapiens_hsa041220.99253407
56Starch and sucrose metabolism_Homo sapiens_hsa005000.90810649
57Insulin secretion_Homo sapiens_hsa049110.90438581
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90022830
59Arginine and proline metabolism_Homo sapiens_hsa003300.88638738
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88165747
61Lysine degradation_Homo sapiens_hsa003100.87625779
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.86835213
63PPAR signaling pathway_Homo sapiens_hsa033200.86611851
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83425080
65Biosynthesis of amino acids_Homo sapiens_hsa012300.78647689
66Arachidonic acid metabolism_Homo sapiens_hsa005900.77913551
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76311822
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.74994264
69Fructose and mannose metabolism_Homo sapiens_hsa000510.71388118
70Carbon metabolism_Homo sapiens_hsa012000.69751029
71Linoleic acid metabolism_Homo sapiens_hsa005910.69230650
72N-Glycan biosynthesis_Homo sapiens_hsa005100.66560679
73Arginine biosynthesis_Homo sapiens_hsa002200.64680097
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64087676
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63603156
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62438475
77Insulin resistance_Homo sapiens_hsa049310.61740940
78Glycerolipid metabolism_Homo sapiens_hsa005610.59714152
79Chemical carcinogenesis_Homo sapiens_hsa052040.59193245
80Nitrogen metabolism_Homo sapiens_hsa009100.59036380
81Pancreatic secretion_Homo sapiens_hsa049720.58371331
82Pertussis_Homo sapiens_hsa051330.57371919
83Tyrosine metabolism_Homo sapiens_hsa003500.56886946
84Oxidative phosphorylation_Homo sapiens_hsa001900.53581402
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53227922
86Vitamin B6 metabolism_Homo sapiens_hsa007500.52875819
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52114132
88Prion diseases_Homo sapiens_hsa050200.51060964
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46252514
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44234360
91Metabolic pathways_Homo sapiens_hsa011000.44107121
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43436278
93Gastric acid secretion_Homo sapiens_hsa049710.42579689
94Fat digestion and absorption_Homo sapiens_hsa049750.41276614
95Type II diabetes mellitus_Homo sapiens_hsa049300.40464189
96Synaptic vesicle cycle_Homo sapiens_hsa047210.39977827
97Galactose metabolism_Homo sapiens_hsa000520.37020924
98Circadian rhythm_Homo sapiens_hsa047100.36842842
99Glucagon signaling pathway_Homo sapiens_hsa049220.34768145
100Regulation of autophagy_Homo sapiens_hsa041400.34746920
101African trypanosomiasis_Homo sapiens_hsa051430.31888681
102Retinol metabolism_Homo sapiens_hsa008300.30820643
103Bladder cancer_Homo sapiens_hsa052190.28987964
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28781059
105Tight junction_Homo sapiens_hsa045300.28492265
106Prostate cancer_Homo sapiens_hsa052150.26224204
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.26177305
108Hepatitis C_Homo sapiens_hsa051600.25398708
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.24607655
110Rheumatoid arthritis_Homo sapiens_hsa053230.24172124
111Cocaine addiction_Homo sapiens_hsa050300.20400602
112Alzheimers disease_Homo sapiens_hsa050100.19390885
113Inositol phosphate metabolism_Homo sapiens_hsa005620.17360116
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16259959
115One carbon pool by folate_Homo sapiens_hsa006700.14873849
116Ether lipid metabolism_Homo sapiens_hsa005650.14733824
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13120326
118Pentose phosphate pathway_Homo sapiens_hsa000300.12844052
119Ovarian steroidogenesis_Homo sapiens_hsa049130.12377338
120Amoebiasis_Homo sapiens_hsa051460.11633044
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.01258471
122TNF signaling pathway_Homo sapiens_hsa04668-0.0156114

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