DEF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.72585415
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.72585415
3positive regulation of gamma-delta T cell activation (GO:0046645)5.39092628
4ribosomal small subunit assembly (GO:0000028)5.13718942
5antigen processing and presentation of endogenous antigen (GO:0019883)4.94302824
6regulation of gamma-delta T cell differentiation (GO:0045586)4.50381177
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44539318
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43966523
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.43966523
10modulation by symbiont of host immune response (GO:0052553)4.43966523
11positive regulation by symbiont of host defense response (GO:0052509)4.43966523
12modulation by symbiont of host defense response (GO:0052031)4.43966523
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43966523
14neutrophil activation involved in immune response (GO:0002283)4.40711884
15viral transcription (GO:0019083)4.38404457
16detection of bacterium (GO:0016045)4.27864514
17detection of other organism (GO:0098543)4.27154317
18translational termination (GO:0006415)4.18646435
19regulation of gamma-delta T cell activation (GO:0046643)4.12852425
20antigen processing and presentation via MHC class Ib (GO:0002475)4.08215077
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01228536
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.01001142
23cellular extravasation (GO:0045123)3.85953925
24tolerance induction (GO:0002507)3.85617774
25ribosomal small subunit biogenesis (GO:0042274)3.82659381
26negative regulation of T cell mediated immunity (GO:0002710)3.79428102
27response to peptidoglycan (GO:0032494)3.75889624
28macrophage activation involved in immune response (GO:0002281)3.74456990
29negative regulation of leukocyte mediated immunity (GO:0002704)3.69760676
30translational elongation (GO:0006414)3.69388895
31DNA deamination (GO:0045006)3.68533703
32negative regulation of interleukin-12 production (GO:0032695)3.67136124
33neutrophil activation (GO:0042119)3.63998008
34regulation of alpha-beta T cell proliferation (GO:0046640)3.62738189
35leukocyte aggregation (GO:0070486)3.61924485
36negative regulation of phagocytosis (GO:0050765)3.60773190
37response to muramyl dipeptide (GO:0032495)3.60066983
38positive regulation of B cell differentiation (GO:0045579)3.59239412
39positive thymic T cell selection (GO:0045059)3.58934764
40negative T cell selection (GO:0043383)3.55758995
41regulation of T cell tolerance induction (GO:0002664)3.53348677
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53194413
43respiratory burst (GO:0045730)3.52841805
44Arp2/3 complex-mediated actin nucleation (GO:0034314)3.46063399
45negative thymic T cell selection (GO:0045060)3.45506873
46nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45413954
47regulation of B cell receptor signaling pathway (GO:0050855)3.43146462
48protein targeting to ER (GO:0045047)3.43103198
49cotranslational protein targeting to membrane (GO:0006613)3.43031939
50detection of external biotic stimulus (GO:0098581)3.38555331
51regulation of B cell differentiation (GO:0045577)3.37967561
52granulocyte activation (GO:0036230)3.35804142
53interferon-gamma production (GO:0032609)3.35299973
54activated T cell proliferation (GO:0050798)3.34094488
55viral life cycle (GO:0019058)3.32201166
56myeloid cell activation involved in immune response (GO:0002275)3.31757385
57regulation of tolerance induction (GO:0002643)3.31216125
58regulation of mast cell degranulation (GO:0043304)3.30538297
59negative regulation of erythrocyte differentiation (GO:0045647)3.28009385
60maturation of SSU-rRNA (GO:0030490)3.27033000
61T cell homeostasis (GO:0043029)3.26105117
62response to interleukin-15 (GO:0070672)3.26093392
63regulation of interferon-beta biosynthetic process (GO:0045357)3.25969458
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25959867
65regulation of natural killer cell mediated immunity (GO:0002715)3.21481903
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.21481903
67protein localization to endoplasmic reticulum (GO:0070972)3.21414043
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.21343979
69regulation of T cell mediated cytotoxicity (GO:0001914)3.19883581
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18575267
71cellular protein complex disassembly (GO:0043624)3.17250330
72translational initiation (GO:0006413)3.15006041
73T cell migration (GO:0072678)3.14994852
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14031126
75mast cell activation (GO:0045576)3.13511483
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13348876
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.12681768
78regulation of regulatory T cell differentiation (GO:0045589)3.12218330
79leukocyte degranulation (GO:0043299)3.12179465
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12072034
81thymic T cell selection (GO:0045061)3.09800587
82definitive hemopoiesis (GO:0060216)3.07344625
83negative regulation of innate immune response (GO:0045824)3.05135382
84telomere maintenance via semi-conservative replication (GO:0032201)3.04695164
85DNA unwinding involved in DNA replication (GO:0006268)3.04656558
86response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04550743
87response to host immune response (GO:0052572)3.04550743
88defense response to protozoan (GO:0042832)3.04235893
89DNA strand elongation involved in DNA replication (GO:0006271)3.02918583
90regulation of interleukin-2 biosynthetic process (GO:0045076)3.00804655
91microglial cell activation (GO:0001774)3.00745417
92regulation of mast cell activation involved in immune response (GO:0033006)2.99959522
93interferon-gamma-mediated signaling pathway (GO:0060333)2.99900362
94immunoglobulin mediated immune response (GO:0016064)2.98972859
95regulation of leukocyte degranulation (GO:0043300)2.98700887
96positive T cell selection (GO:0043368)2.98133306
97detection of biotic stimulus (GO:0009595)2.96029651
98megakaryocyte development (GO:0035855)2.95679523
99positive regulation of tolerance induction (GO:0002645)2.95522425
100regulation of antigen processing and presentation (GO:0002577)2.95381611
101B cell receptor signaling pathway (GO:0050853)2.94426237
102NIK/NF-kappaB signaling (GO:0038061)2.93719229
103germinal center formation (GO:0002467)2.93323192
104T cell selection (GO:0045058)2.92402028
105dendritic cell chemotaxis (GO:0002407)2.91792915
106regulation of T cell receptor signaling pathway (GO:0050856)2.91192278
107protein complex disassembly (GO:0043241)2.90284255
108DNA strand elongation (GO:0022616)2.89754671
109regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.88572835
110positive regulation of antigen processing and presentation (GO:0002579)2.88499454
111T cell receptor signaling pathway (GO:0050852)2.83525029
112response to protozoan (GO:0001562)2.83194200
113B cell mediated immunity (GO:0019724)2.82962679
114negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82720596
115negative regulation of T-helper cell differentiation (GO:0045623)2.82720596
116antigen receptor-mediated signaling pathway (GO:0050851)2.80375964
117mast cell degranulation (GO:0043303)2.80245910
118mast cell activation involved in immune response (GO:0002279)2.80245910
119regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.74808184
120nuclear-transcribed mRNA catabolic process (GO:0000956)2.73053897
121negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72953716
122regulation of necroptotic process (GO:0060544)2.72854894
123lymphocyte homeostasis (GO:0002260)2.70119621
124cellular response to interleukin-15 (GO:0071350)2.70002983
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69540096
126natural killer cell differentiation (GO:0001779)2.69125622
127macromolecular complex disassembly (GO:0032984)2.67936955
128formation of translation preinitiation complex (GO:0001731)2.67476283
129Peyers patch development (GO:0048541)2.64260018
130mucosal-associated lymphoid tissue development (GO:0048537)2.64260018
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.62738308
132DNA replication initiation (GO:0006270)2.62718007
133positive regulation of granulocyte differentiation (GO:0030854)2.62361015
1343-UTR-mediated mRNA stabilization (GO:0070935)2.62273374
135mRNA catabolic process (GO:0006402)2.61838731
136negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61553520
137negative regulation of cell killing (GO:0031342)2.61553520
138telomere maintenance via recombination (GO:0000722)2.60690399
139cellular response to interleukin-4 (GO:0071353)2.60547023
140T cell costimulation (GO:0031295)2.59574609
141lymphocyte costimulation (GO:0031294)2.58107524
142positive regulation of isotype switching (GO:0045830)2.56446822
143response to type I interferon (GO:0034340)2.56364302
144regulation of response to interferon-gamma (GO:0060330)2.55108900
145RNA catabolic process (GO:0006401)2.54094642
146type I interferon signaling pathway (GO:0060337)2.53364668
147cellular response to type I interferon (GO:0071357)2.53364668
148positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53273235
149regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.52635033
150leukocyte homeostasis (GO:0001776)2.51118041
151regulation of interleukin-12 biosynthetic process (GO:0045075)2.48572694
152ribonucleoprotein complex biogenesis (GO:0022613)2.48285965
153natural killer cell activation (GO:0030101)2.48173975
154protein localization to kinetochore (GO:0034501)2.48097101
155lymph node development (GO:0048535)2.47734831
156response to interferon-beta (GO:0035456)2.47625024
157regulation of erythrocyte differentiation (GO:0045646)2.46928139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.08057753
2MYC_22102868_ChIP-Seq_BL_Human3.20218481
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13042751
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.88084602
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78505084
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74747549
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.68285461
8VDR_21846776_ChIP-Seq_THP-1_Human2.68024142
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63787580
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62868676
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62776423
12SCL_19346495_ChIP-Seq_HPC-7_Human2.60222425
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.51351019
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48780489
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.37380504
16* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27952639
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24688133
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18473652
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15203721
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.12262764
21MYB_26560356_Chip-Seq_TH2_Human2.11779042
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08973973
23MAF_26560356_Chip-Seq_TH1_Human2.08956637
24* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06050446
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03212479
26* SPI1_23547873_ChIP-Seq_NB4_Human2.01672279
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.98864566
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.98698005
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.94633527
30UTX_26944678_Chip-Seq_JUKART_Human1.92316632
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91312395
32MYB_26560356_Chip-Seq_TH1_Human1.89631214
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87359977
34* RUNX1_22412390_ChIP-Seq_EML_Mouse1.81548188
35SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.80664315
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77873056
37CIITA_25753668_ChIP-Seq_RAJI_Human1.76205075
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75371098
39VDR_24763502_ChIP-Seq_THP-1_Human1.74279464
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74269287
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73582393
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71341154
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.70738223
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66771405
45* VDR_23849224_ChIP-Seq_CD4+_Human1.66609944
46FOXP3_21729870_ChIP-Seq_TREG_Human1.62666622
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61308016
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61005485
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.60273012
50RUNX_20019798_ChIP-Seq_JUKART_Human1.59741926
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59722350
52XRN2_22483619_ChIP-Seq_HELA_Human1.56075399
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56022994
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54807328
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.52388826
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51673830
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.50086343
58MAF_26560356_Chip-Seq_TH2_Human1.48278319
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48126788
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47193050
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45740214
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45638752
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45450239
64GATA3_26560356_Chip-Seq_TH2_Human1.44565352
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42477566
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41125626
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.40554808
68* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39870907
69* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37881387
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36675243
71LXR_22292898_ChIP-Seq_THP-1_Human1.35503797
72VDR_24787735_ChIP-Seq_THP-1_Human1.32222688
73BCL6_27268052_Chip-Seq_Bcells_Human1.32117853
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31268865
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31095448
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30456113
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29615724
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28979256
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.28586631
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27210951
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26240819
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25879264
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.24288062
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.23756602
85GATA1_22025678_ChIP-Seq_K562_Human1.22951302
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22764292
87GATA1_19941826_ChIP-Seq_K562_Human1.22140858
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21762360
89* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21263258
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.19895352
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19871449
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19516104
93BCOR_27268052_Chip-Seq_Bcells_Human1.19230907
94GABP_19822575_ChIP-Seq_HepG2_Human1.17812240
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16404209
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15577361
97SPI1_23127762_ChIP-Seq_K562_Human1.14569821
98PU_27001747_Chip-Seq_BMDM_Mouse1.14555555
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14488768
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14284894
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.12368111
102VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12252662
103DCP1A_22483619_ChIP-Seq_HELA_Human1.10928269
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10614785
105KDM2B_26808549_Chip-Seq_DND41_Human1.10289615
106CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10106137
107TTF2_22483619_ChIP-Seq_HELA_Human1.08494187
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07732736
109GATA3_27048872_Chip-Seq_THYMUS_Human1.07431874
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07187900
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05024772
112ELK1_19687146_ChIP-ChIP_HELA_Human1.05005932
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04623930
114NCOR1_26117541_ChIP-Seq_K562_Human1.04136476
115CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02253501
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00606564
117CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00553599
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99800395
119TFEB_21752829_ChIP-Seq_HELA_Human0.99681318
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98414093
121KDM5A_27292631_Chip-Seq_BREAST_Human0.98019033
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97630725
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97006551
124ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96952583
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96496708
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94812956
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94558257
128* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92974879
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92033105
130SPI1_20517297_ChIP-Seq_HL60_Human0.91427966
131P68_20966046_ChIP-Seq_HELA_Human0.91004342
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.90564091
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90327282
134* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89709681
135P300_27268052_Chip-Seq_Bcells_Human0.89510267
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84862914
137GATA2_19941826_ChIP-Seq_K562_Human0.83905914
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82505779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.67797044
2MP0003763_abnormal_thymus_physiology3.66982746
3MP0001835_abnormal_antigen_presentation3.50924469
4MP0000685_abnormal_immune_system3.33486828
5MP0005671_abnormal_response_to3.13120351
6* MP0001800_abnormal_humoral_immune2.71917275
7* MP0002398_abnormal_bone_marrow2.65217961
8MP0009785_altered_susceptibility_to2.57150704
9MP0003436_decreased_susceptibility_to2.50724639
10* MP0002420_abnormal_adaptive_immunity2.45697857
11MP0004808_abnormal_hematopoietic_stem2.45693979
12MP0002166_altered_tumor_susceptibility2.43562881
13* MP0001819_abnormal_immune_cell2.42339602
14MP0001790_abnormal_immune_system2.39694561
15MP0005387_immune_system_phenotype2.39694561
16* MP0002452_abnormal_antigen_presenting2.38446189
17* MP0002723_abnormal_immune_serum2.35006706
18MP0009333_abnormal_splenocyte_physiolog2.34004349
19MP0005025_abnormal_response_to2.33937131
20* MP0005000_abnormal_immune_tolerance2.32456405
21* MP0000716_abnormal_immune_system2.23439138
22* MP0002722_abnormal_immune_system2.22247276
23MP0005397_hematopoietic_system_phenotyp2.21238451
24MP0001545_abnormal_hematopoietic_system2.21238451
25* MP0000689_abnormal_spleen_morphology2.18936199
26MP0000703_abnormal_thymus_morphology2.18004811
27MP0003693_abnormal_embryo_hatching2.16246942
28MP0002405_respiratory_system_inflammati2.14897942
29MP0005464_abnormal_platelet_physiology2.14478129
30* MP0002429_abnormal_blood_cell2.00844741
31MP0010155_abnormal_intestine_physiology1.98992520
32MP0010094_abnormal_chromosome_stability1.98767295
33MP0001873_stomach_inflammation1.97299402
34MP0008057_abnormal_DNA_replication1.97150066
35MP0002419_abnormal_innate_immunity1.93174610
36MP0000490_abnormal_crypts_of1.92308613
37MP0002006_tumorigenesis1.89934412
38MP0005075_abnormal_melanosome_morpholog1.84207593
39MP0009278_abnormal_bone_marrow1.82660862
40MP0000465_gastrointestinal_hemorrhage1.79804890
41MP0002148_abnormal_hypersensitivity_rea1.77427121
42MP0003077_abnormal_cell_cycle1.74434200
43MP0003303_peritoneal_inflammation1.74092960
44MP0003724_increased_susceptibility_to1.73009314
45MP0003300_gastrointestinal_ulcer1.69488673
46MP0003111_abnormal_nucleus_morphology1.67374891
47MP0003866_abnormal_defecation1.66821625
48MP0001853_heart_inflammation1.65980170
49MP0005174_abnormal_tail_pigmentation1.65773819
50MP0004957_abnormal_blastocyst_morpholog1.63883251
51MP0010352_gastrointestinal_tract_polyps1.56627469
52MP0004947_skin_inflammation1.53181418
53MP0008260_abnormal_autophagy1.51695207
54MP0001845_abnormal_inflammatory_respons1.49340878
55MP0002019_abnormal_tumor_incidence1.44209835
56MP0006082_CNS_inflammation1.43970561
57MP0000858_altered_metastatic_potential1.43323566
58MP0008058_abnormal_DNA_repair1.33814754
59MP0008007_abnormal_cellular_replicative1.28933884
60MP0002933_joint_inflammation1.28785845
61MP0010307_abnormal_tumor_latency1.23709154
62MP0005058_abnormal_lysosome_morphology1.17828783
63MP0005451_abnormal_body_composition1.17050579
64MP0002998_abnormal_bone_remodeling1.16293068
65MP0002132_abnormal_respiratory_system1.10322175
66MP0001533_abnormal_skeleton_physiology1.09720672
67MP0002095_abnormal_skin_pigmentation1.07646415
68MP0000313_abnormal_cell_death1.05873912
69MP0008469_abnormal_protein_level1.03554674
70MP0002009_preneoplasia1.03210863
71MP0005310_abnormal_salivary_gland1.02923103
72MP0000350_abnormal_cell_proliferation0.97834481
73MP0002277_abnormal_respiratory_mucosa0.97636996
74MP0004883_abnormal_blood_vessel0.94883754
75MP0005023_abnormal_wound_healing0.94440602
76MP0003448_altered_tumor_morphology0.94185707
77MP0003172_abnormal_lysosome_physiology0.87513281
78MP0003075_altered_response_to0.86647835
79MP0005166_decreased_susceptibility_to0.86644208
80MP0004510_myositis0.85482890
81MP0002138_abnormal_hepatobiliary_system0.84727320
82MP0003806_abnormal_nucleotide_metabolis0.82021464
83MP0001348_abnormal_lacrimal_gland0.80556234
84MP0000015_abnormal_ear_pigmentation0.80402153
85MP0003786_premature_aging0.76512431
86MP0001851_eye_inflammation0.76028059
87MP0000477_abnormal_intestine_morphology0.74927368
88MP0000604_amyloidosis0.72981079
89MP0000343_altered_response_to0.72244229
90MP0001730_embryonic_growth_arrest0.70663644
91MP0003656_abnormal_erythrocyte_physiolo0.69607975
92MP0003690_abnormal_glial_cell0.69122034
93MP0005076_abnormal_cell_differentiation0.68737280
94MP0006054_spinal_hemorrhage0.68130460
95MP0003943_abnormal_hepatobiliary_system0.66878141
96MP0005164_abnormal_response_to0.66561807
97MP0009765_abnormal_xenobiotic_induced0.65566284
98MP0002877_abnormal_melanocyte_morpholog0.65151640
99MP0009840_abnormal_foam_cell0.64322192
100MP0003795_abnormal_bone_structure0.63570988
101MP0003566_abnormal_cell_adhesion0.63543390
102MP0001986_abnormal_taste_sensitivity0.61991411
103MP0002080_prenatal_lethality0.60663571
104MP0000249_abnormal_blood_vessel0.59513136
105MP0004381_abnormal_hair_follicle0.58732523
106MP0003045_fibrosis0.57570607
107MP0003183_abnormal_peptide_metabolism0.56919526
108MP0003191_abnormal_cellular_cholesterol0.56782649
109MP0009763_increased_sensitivity_to0.56530060
110MP0002086_abnormal_extraembryonic_tissu0.56416063
111MP0009931_abnormal_skin_appearance0.55685377
112MP0001663_abnormal_digestive_system0.54726335
113MP0008004_abnormal_stomach_pH0.54199753
114MP0005390_skeleton_phenotype0.53947112
115MP0003828_pulmonary_edema0.53490940
116MP0000371_diluted_coat_color0.52648026
117MP0002693_abnormal_pancreas_physiology0.52120617
118MP0001697_abnormal_embryo_size0.51316754
119MP0008874_decreased_physiological_sensi0.50628479
120MP0004130_abnormal_muscle_cell0.50538840
121MP0009764_decreased_sensitivity_to0.50131163
122MP0000358_abnormal_cell_content/0.50052314
123MP0005621_abnormal_cell_physiology0.49370706
124MP0000609_abnormal_liver_physiology0.49231247
125MP0004185_abnormal_adipocyte_glucose0.49046915
126MP0005381_digestive/alimentary_phenotyp0.47322643
127MP0005319_abnormal_enzyme/_coenzyme0.45690296
128MP0008873_increased_physiological_sensi0.42956140
129MP0004264_abnormal_extraembryonic_tissu0.37747160
130MP0005535_abnormal_body_temperature0.37472276

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.82225710
2Elevated erythrocyte sedimentation rate (HP:0003565)4.76037035
3Chronic otitis media (HP:0000389)4.60053860
4Thrombocytosis (HP:0001894)4.26364236
5Optic neuritis (HP:0100653)4.05402332
6Retrobulbar optic neuritis (HP:0100654)4.05402332
7Recurrent bronchitis (HP:0002837)4.04382559
8Panhypogammaglobulinemia (HP:0003139)4.03860584
9Recurrent gram-negative bacterial infections (HP:0005420)3.98333221
10Recurrent fungal infections (HP:0002841)3.98172554
11Nasal polyposis (HP:0100582)3.89450488
12Recurrent viral infections (HP:0004429)3.89316800
13Abnormality of T cells (HP:0002843)3.81166078
14Eczematoid dermatitis (HP:0000976)3.80516362
15T lymphocytopenia (HP:0005403)3.80081465
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.78388140
17Myositis (HP:0100614)3.78186069
18Abnormality of cells of the erythroid lineage (HP:0012130)3.69366681
19Petechiae (HP:0000967)3.68313655
20Gastrointestinal infarctions (HP:0005244)3.66739716
21Abnormality of T cell number (HP:0011839)3.62981696
22Recurrent abscess formation (HP:0002722)3.59946311
23Abnormality of T cell physiology (HP:0011840)3.59280695
24Abnormality of the nasal mucosa (HP:0000433)3.57856842
25Abnormal number of erythroid precursors (HP:0012131)3.57789481
26Reticulocytopenia (HP:0001896)3.39105303
27Aplastic anemia (HP:0001915)3.38690823
28Abnormality of B cell number (HP:0010975)3.36438664
29B lymphocytopenia (HP:0010976)3.36438664
30Prolonged bleeding time (HP:0003010)3.27348865
31Urticaria (HP:0001025)3.14187865
32Meningitis (HP:0001287)3.13644987
33Cellulitis (HP:0100658)3.11652396
34IgG deficiency (HP:0004315)3.10488809
35Combined immunodeficiency (HP:0005387)3.09762603
36Gingivitis (HP:0000230)3.04015163
37Autoimmune hemolytic anemia (HP:0001890)3.03589257
38Recurrent cutaneous fungal infections (HP:0011370)3.01886083
39Chronic mucocutaneous candidiasis (HP:0002728)3.01886083
40Severe combined immunodeficiency (HP:0004430)3.01884442
41Pulmonary infiltrates (HP:0002113)2.99330912
42Recurrent bacterial skin infections (HP:0005406)2.98245411
43Keratoconjunctivitis sicca (HP:0001097)2.98238537
44Pustule (HP:0200039)2.98061387
45Gastrointestinal inflammation (HP:0004386)2.96707155
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.86509686
47Lymphopenia (HP:0001888)2.86062206
48Inflammation of the large intestine (HP:0002037)2.82110124
49Keratoconjunctivitis (HP:0001096)2.80168538
50Lymphoma (HP:0002665)2.77540901
51Thyroiditis (HP:0100646)2.70955735
52Agammaglobulinemia (HP:0004432)2.69953357
53Eosinophilia (HP:0001880)2.69046393
54Granulocytopenia (HP:0001913)2.68299704
55Leukocytosis (HP:0001974)2.65117459
56Basal cell carcinoma (HP:0002671)2.64831590
57Epistaxis (HP:0000421)2.64690987
58Recurrent skin infections (HP:0001581)2.61312190
59Spontaneous hematomas (HP:0007420)2.60282085
60Obstructive lung disease (HP:0006536)2.58687150
61Chronic obstructive pulmonary disease (HP:0006510)2.58687150
62Osteomyelitis (HP:0002754)2.57216769
63Poikiloderma (HP:0001029)2.54851956
64Increased IgE level (HP:0003212)2.54199268
65Abnormality of eosinophils (HP:0001879)2.53180561
66Pallor (HP:0000980)2.51807865
67Abnormality of the fingertips (HP:0001211)2.51527541
68Mediastinal lymphadenopathy (HP:0100721)2.46524853
69Sepsis (HP:0100806)2.42935222
70Vasculitis (HP:0002633)2.42004693
71Hypochromic microcytic anemia (HP:0004840)2.41277856
72Pulmonary embolism (HP:0002204)2.39821300
73Abnormal platelet function (HP:0011869)2.37728713
74Impaired platelet aggregation (HP:0003540)2.37728713
75Stomatitis (HP:0010280)2.37692352
76IgA deficiency (HP:0002720)2.36673504
77Episodic fever (HP:0001954)2.34878041
78Arterial thrombosis (HP:0004420)2.33980223
79Amaurosis fugax (HP:0100576)2.32216233
80Myelodysplasia (HP:0002863)2.27325860
81Anorexia (HP:0002039)2.26181911
82Hypoplasia of the thymus (HP:0000778)2.23351530
83Chest pain (HP:0100749)2.21901262
84Hypergammaglobulinemia (HP:0010702)2.21719892
85Chronic sinusitis (HP:0011109)2.19842842
86Orchitis (HP:0100796)2.19101126
87Encephalitis (HP:0002383)2.15989990
88Bronchitis (HP:0012387)2.15573564
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15452460
90Abnormality of the prostate (HP:0008775)2.13849951
91Colitis (HP:0002583)2.12761375
92Abnormality of macrophages (HP:0004311)2.12693108
93Abnormality of the pleura (HP:0002103)2.12399708
94Abnormal platelet volume (HP:0011876)2.12304606
95Gangrene (HP:0100758)2.11288260
96Verrucae (HP:0200043)2.10929851
97Papilloma (HP:0012740)2.10929851
98Increased serum ferritin (HP:0003281)2.09679617
99Gastrointestinal stroma tumor (HP:0100723)2.09344072
100Emphysema (HP:0002097)2.08539533
101Skin rash (HP:0000988)2.08061660
102Viral hepatitis (HP:0006562)2.07908415
103Acute hepatic failure (HP:0006554)2.03811251
104Increased cerebral lipofuscin (HP:0011813)2.03764460
105Joint swelling (HP:0001386)2.03217182
106Hemoptysis (HP:0002105)2.03199865
107Chronic diarrhea (HP:0002028)2.03173613
108Purpura (HP:0000979)2.03080479
109Entropion (HP:0000621)2.02635475
110Aplasia/Hypoplasia of the thymus (HP:0010515)2.01599618
111Microcytic anemia (HP:0001935)2.01284985
112Slow saccadic eye movements (HP:0000514)2.01271081
113Cheilitis (HP:0100825)2.01186811
114Skin ulcer (HP:0200042)2.00276004
115Glomerulopathy (HP:0100820)1.99704534
116Hepatosplenomegaly (HP:0001433)1.99167476
117Hypochromic anemia (HP:0001931)1.98163374
118Acute myeloid leukemia (HP:0004808)1.96298388
119Increased IgM level (HP:0003496)1.96106340
120Reduced antithrombin III activity (HP:0001976)1.95914108
121Interstitial pulmonary disease (HP:0006530)1.94951064
122Autoimmune thrombocytopenia (HP:0001973)1.94322094
123Gingival bleeding (HP:0000225)1.93044250
124Recurrent sinusitis (HP:0011108)1.92329477
125Macrocytic anemia (HP:0001972)1.91707193
126Abnormality of iron homeostasis (HP:0011031)1.89525462
127Albinism (HP:0001022)1.89037356
128Loss of speech (HP:0002371)1.88204956
129Increased density of long bones (HP:0006392)1.85111914
130Prominent nose (HP:0000448)1.84599734
131Acute lymphatic leukemia (HP:0006721)1.83530412
132Agnosia (HP:0010524)1.80144710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.82939975
2EEF2K3.06633919
3ZAP702.63423973
4TXK2.62855586
5PRPF4B2.54947624
6JAK32.47903822
7NME22.25936119
8BTK2.19558011
9KIT2.19531712
10STK102.14183035
11GRK62.14002247
12MAP3K101.99142388
13TYK21.90121372
14FLT31.89268424
15TEC1.84706365
16CSF1R1.81757156
17BLK1.80393646
18TESK21.68630610
19IKBKE1.66516477
20KDR1.65803067
21SYK1.62606494
22PKN21.61099551
23PIM21.60301520
24MAP3K131.57793255
25ITK1.50940066
26ERN11.46104092
27LRRK21.45541388
28TGFBR11.45440915
29TBK11.44675413
30RPS6KB21.43637281
31MAP2K31.40873245
32IRAK41.38249638
33NEK21.37246026
34CDC71.34711779
35* LCK1.29542901
36TAOK11.27798167
37PIM11.25509079
38MAP3K31.22836874
39TGFBR21.17757825
40FES1.17553543
41CDK121.17368343
42HCK1.13990515
43RPS6KA41.13933492
44FGR1.12273092
45MAP3K11.10693129
46IKBKB1.09769400
47CSK1.08132063
48TRIB31.06363991
49FGFR41.04936283
50WEE11.03032812
51NLK1.02272016
52BMPR21.01755077
53MAPKAPK30.97940297
54TNK20.97455342
55SCYL20.96405349
56LYN0.95001895
57FGFR30.92701609
58CLK10.90141366
59MAP3K110.88922595
60CDK70.88485303
61CDK40.87803134
62ACVR1B0.87121980
63SMG10.87104360
64MAP3K140.86566995
65SIK20.85813248
66PRKCQ0.85602078
67TAOK20.85549351
68PASK0.84191639
69STK160.83747707
70JAK10.83647567
71BUB10.82445709
72DYRK30.81620007
73MARK20.77722527
74MATK0.77511546
75PDK10.77075069
76MAPK120.76973622
77CAMKK20.76609246
78TRPM70.75814488
79EIF2AK30.75569291
80ATR0.74952712
81TAOK30.73906628
82STK40.72419335
83MAP3K120.72303608
84EIF2AK10.71606452
85CAMKK10.69961401
86MAP3K60.69076583
87PAK40.68331607
88MAP2K20.68243786
89PRKD20.66994910
90VRK10.66502681
91CDK190.64805673
92PTK60.64394166
93MAP3K80.63823338
94HIPK20.63571213
95FYN0.61942824
96PIK3CG0.60345890
97MAPK70.58116445
98MAPK40.58032580
99EPHB10.57279279
100YES10.56770725
101SIK10.55752216
102CDC42BPA0.54862876
103SIK30.54147703
104TLK10.54040261
105JAK20.53062130
106MARK30.52519607
107CHUK0.51772835
108KSR20.51392739
109RPS6KA60.51236952
110MST40.50967912
111AURKB0.50076775
112ALK0.48040594
113GRK70.47623085
114MAPK110.47065433
115IRAK10.46957947
116PDPK10.45474851
117MAP2K60.43306973
118CDK60.42849803
119STK240.42462311
120RPS6KC10.42241496
121RPS6KL10.42241496
122MAPKAPK20.41842956
123ADRBK20.41531020
124IRAK20.40956924
125RIPK40.39913868
126MAP3K70.39588267
127TESK10.36538003
128IRAK30.34461678
129PRKG20.34319160
130RET0.34016081
131ILK0.33929385
132PLK10.32102571
133DYRK1B0.31093237
134MAP3K50.30117909
135PRKCH0.28963571
136RAF10.28946855
137STK110.27367482
138PTK2B0.27355775

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.87152731
2DNA replication_Homo sapiens_hsa030303.46864662
3Ribosome_Homo sapiens_hsa030103.32292068
4Mismatch repair_Homo sapiens_hsa034302.61167616
5Staphylococcus aureus infection_Homo sapiens_hsa051502.38463366
6Base excision repair_Homo sapiens_hsa034102.33872688
7Type I diabetes mellitus_Homo sapiens_hsa049402.22976915
8Spliceosome_Homo sapiens_hsa030401.99467199
9Antigen processing and presentation_Homo sapiens_hsa046121.96317555
10Measles_Homo sapiens_hsa051621.96180977
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.95335356
12Leishmaniasis_Homo sapiens_hsa051401.90465033
13B cell receptor signaling pathway_Homo sapiens_hsa046621.90183210
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.88757511
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87237334
16T cell receptor signaling pathway_Homo sapiens_hsa046601.85512306
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85462609
18Hematopoietic cell lineage_Homo sapiens_hsa046401.81536320
19Homologous recombination_Homo sapiens_hsa034401.74292570
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69355338
21Herpes simplex infection_Homo sapiens_hsa051681.69037695
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66631064
23Non-homologous end-joining_Homo sapiens_hsa034501.59092591
24Nucleotide excision repair_Homo sapiens_hsa034201.55806513
25Acute myeloid leukemia_Homo sapiens_hsa052211.49549910
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49319179
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47905940
28Osteoclast differentiation_Homo sapiens_hsa043801.47196570
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.40489819
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37592650
31Cell cycle_Homo sapiens_hsa041101.33224950
32RNA transport_Homo sapiens_hsa030131.31668645
33Shigellosis_Homo sapiens_hsa051311.30887000
34Allograft rejection_Homo sapiens_hsa053301.23605663
35Pyrimidine metabolism_Homo sapiens_hsa002401.21076158
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19181491
37Proteasome_Homo sapiens_hsa030501.17567174
38p53 signaling pathway_Homo sapiens_hsa041151.16722146
39Hepatitis B_Homo sapiens_hsa051611.15816002
40Apoptosis_Homo sapiens_hsa042101.15631635
41RNA degradation_Homo sapiens_hsa030181.14963291
42Rheumatoid arthritis_Homo sapiens_hsa053231.13246392
43Legionellosis_Homo sapiens_hsa051341.11512552
44Fanconi anemia pathway_Homo sapiens_hsa034601.11173921
45One carbon pool by folate_Homo sapiens_hsa006701.07058753
46African trypanosomiasis_Homo sapiens_hsa051431.05477704
47Toxoplasmosis_Homo sapiens_hsa051451.05417797
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.05287141
49Epstein-Barr virus infection_Homo sapiens_hsa051691.05232482
50RNA polymerase_Homo sapiens_hsa030201.04478067
51Chronic myeloid leukemia_Homo sapiens_hsa052201.03519933
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99978831
53Influenza A_Homo sapiens_hsa051640.99802934
54HTLV-I infection_Homo sapiens_hsa051660.99032934
55Viral carcinogenesis_Homo sapiens_hsa052030.98764816
56Other glycan degradation_Homo sapiens_hsa005110.98728214
57Platelet activation_Homo sapiens_hsa046110.97993547
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96974973
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96843187
60Asthma_Homo sapiens_hsa053100.96249719
61Viral myocarditis_Homo sapiens_hsa054160.96222132
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93790639
63Phagosome_Homo sapiens_hsa041450.91228870
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86773109
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83702435
66Chemokine signaling pathway_Homo sapiens_hsa040620.83220295
67Sulfur relay system_Homo sapiens_hsa041220.81689410
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78914339
69Thyroid cancer_Homo sapiens_hsa052160.78699182
70Pancreatic cancer_Homo sapiens_hsa052120.77263337
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76771291
72Pentose phosphate pathway_Homo sapiens_hsa000300.75916705
73mRNA surveillance pathway_Homo sapiens_hsa030150.75191096
74Graft-versus-host disease_Homo sapiens_hsa053320.75111168
75TNF signaling pathway_Homo sapiens_hsa046680.73724371
76Colorectal cancer_Homo sapiens_hsa052100.73713084
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72493160
78Non-small cell lung cancer_Homo sapiens_hsa052230.69755435
79Tuberculosis_Homo sapiens_hsa051520.69036473
80Lysosome_Homo sapiens_hsa041420.68359430
81Pertussis_Homo sapiens_hsa051330.68121483
82Malaria_Homo sapiens_hsa051440.67932303
83Salmonella infection_Homo sapiens_hsa051320.65730477
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64820467
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64673154
86Small cell lung cancer_Homo sapiens_hsa052220.64654981
87VEGF signaling pathway_Homo sapiens_hsa043700.64375477
88Endocytosis_Homo sapiens_hsa041440.63235412
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63232744
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63031274
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.59718222
92Notch signaling pathway_Homo sapiens_hsa043300.59489297
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.58520649
94Basal transcription factors_Homo sapiens_hsa030220.56339250
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55021764
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53856096
97Renal cell carcinoma_Homo sapiens_hsa052110.52831448
98Autoimmune thyroid disease_Homo sapiens_hsa053200.52723485
99Hepatitis C_Homo sapiens_hsa051600.52249840
100Prolactin signaling pathway_Homo sapiens_hsa049170.51867025
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51807209
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51425311
103N-Glycan biosynthesis_Homo sapiens_hsa005100.50943296
104Systemic lupus erythematosus_Homo sapiens_hsa053220.50806743
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.48255291
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.48056889
107Inositol phosphate metabolism_Homo sapiens_hsa005620.47633205
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.47350901
109FoxO signaling pathway_Homo sapiens_hsa040680.46629168
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.46440034
111Choline metabolism in cancer_Homo sapiens_hsa052310.44733519
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44661078
113MAPK signaling pathway_Homo sapiens_hsa040100.41927135
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41835494
115mTOR signaling pathway_Homo sapiens_hsa041500.41144384
116Endometrial cancer_Homo sapiens_hsa052130.40683222
117HIF-1 signaling pathway_Homo sapiens_hsa040660.40584418
118Purine metabolism_Homo sapiens_hsa002300.39402588
119Regulation of autophagy_Homo sapiens_hsa041400.38350434
120Galactose metabolism_Homo sapiens_hsa000520.36916604
121Insulin resistance_Homo sapiens_hsa049310.33129390
122GnRH signaling pathway_Homo sapiens_hsa049120.33101859
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31685194
124Pathways in cancer_Homo sapiens_hsa052000.31594400
125MicroRNAs in cancer_Homo sapiens_hsa052060.31556604
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30706707
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29860826
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29270050
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27646879
130Amoebiasis_Homo sapiens_hsa051460.26327971
131ErbB signaling pathway_Homo sapiens_hsa040120.22107258
132Dorso-ventral axis formation_Homo sapiens_hsa043200.21049611
133Type II diabetes mellitus_Homo sapiens_hsa049300.20187716
134Prostate cancer_Homo sapiens_hsa052150.19158544
135Rap1 signaling pathway_Homo sapiens_hsa040150.17015819

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