DEDD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)6.27833932
2mitotic metaphase plate congression (GO:0007080)4.83735983
3piRNA metabolic process (GO:0034587)4.78300633
4platelet dense granule organization (GO:0060155)4.60771115
5respiratory chain complex IV assembly (GO:0008535)4.59984461
6DNA deamination (GO:0045006)4.55779443
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.45792175
8cytochrome complex assembly (GO:0017004)4.43401842
9protein complex biogenesis (GO:0070271)4.40561512
10cullin deneddylation (GO:0010388)4.19716488
11multicellular organism reproduction (GO:0032504)4.15103688
12protein deneddylation (GO:0000338)4.11948888
13regulation of RIG-I signaling pathway (GO:0039535)4.10441743
14chaperone-mediated protein transport (GO:0072321)4.07740024
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95701780
16establishment of chromosome localization (GO:0051303)3.91031282
17mitochondrial respiratory chain complex assembly (GO:0033108)3.89560772
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.83063819
19NADH dehydrogenase complex assembly (GO:0010257)3.83063819
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.83063819
21metaphase plate congression (GO:0051310)3.82755678
22replication fork processing (GO:0031297)3.82012375
23maturation of 5.8S rRNA (GO:0000460)3.77243604
24DNA double-strand break processing (GO:0000729)3.66798370
25proteasome assembly (GO:0043248)3.65354265
26lactate metabolic process (GO:0006089)3.63911048
27microtubule depolymerization (GO:0007019)3.60061511
28regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.57731871
29regulation of cellular amino acid metabolic process (GO:0006521)3.55550153
30electron transport chain (GO:0022900)3.44087610
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43515228
32respiratory electron transport chain (GO:0022904)3.41030880
33protein K6-linked ubiquitination (GO:0085020)3.40628869
34binding of sperm to zona pellucida (GO:0007339)3.35311919
35negative regulation of execution phase of apoptosis (GO:1900118)3.32513942
36DNA methylation involved in gamete generation (GO:0043046)3.28043596
37inner mitochondrial membrane organization (GO:0007007)3.24594879
38keratinocyte development (GO:0003334)3.24274141
39reproduction (GO:0000003)3.23592330
40inositol phosphate catabolic process (GO:0071545)3.21419005
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18692822
42ATP synthesis coupled proton transport (GO:0015986)3.18692822
43signal transduction involved in DNA damage checkpoint (GO:0072422)3.15769019
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15769019
45signal transduction involved in cell cycle checkpoint (GO:0072395)3.15765858
46cellular response to virus (GO:0098586)3.15186790
47meiotic chromosome segregation (GO:0045132)3.14098931
48sperm-egg recognition (GO:0035036)3.09467615
49oocyte maturation (GO:0001556)3.04127639
50pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03370634
51superoxide anion generation (GO:0042554)3.01876721
52regulation of female gonad development (GO:2000194)3.00431317
53mannosylation (GO:0097502)2.98722889
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98239316
55regulation of mitochondrial translation (GO:0070129)2.97819933
56signal peptide processing (GO:0006465)2.97706806
57regulation of exit from mitosis (GO:0007096)2.95341590
58rRNA modification (GO:0000154)2.91665889
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88044652
60attachment of spindle microtubules to kinetochore (GO:0008608)2.87932061
61CENP-A containing nucleosome assembly (GO:0034080)2.86696589
62adenosine metabolic process (GO:0046085)2.85683087
63pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85005286
64cytidine deamination (GO:0009972)2.83968324
65cytidine metabolic process (GO:0046087)2.83968324
66cytidine catabolic process (GO:0006216)2.83968324
67heart contraction (GO:0060047)2.83858238
68heart process (GO:0003015)2.83858238
69histone H2A acetylation (GO:0043968)2.80787565
70immunoglobulin mediated immune response (GO:0016064)2.78816203
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78674048
72hydrogen peroxide biosynthetic process (GO:0050665)2.77730550
73kinetochore assembly (GO:0051382)2.76588761
74cell-cell recognition (GO:0009988)2.75494768
75regulation of G0 to G1 transition (GO:0070316)2.75153390
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.74712989
77chromatin remodeling at centromere (GO:0031055)2.74466550
78purine-containing compound salvage (GO:0043101)2.72469236
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71672463
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71672463
81positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.71363499
827-methylguanosine mRNA capping (GO:0006370)2.70399724
83positive regulation of cell cycle arrest (GO:0071158)2.69433334
84DNA catabolic process, exonucleolytic (GO:0000738)2.69360355
85viral mRNA export from host cell nucleus (GO:0046784)2.69292809
86protein K11-linked ubiquitination (GO:0070979)2.69102833
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69043739
88regulation of double-strand break repair via homologous recombination (GO:0010569)2.67115287
89sequestering of actin monomers (GO:0042989)2.67025548
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66245083
91RNA capping (GO:0036260)2.64911289
927-methylguanosine RNA capping (GO:0009452)2.64911289
93inositol phosphate dephosphorylation (GO:0046855)2.64522826
94phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64522826
95positive regulation of humoral immune response (GO:0002922)2.64102299
96mitotic sister chromatid segregation (GO:0000070)2.63290311
97negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63176139
98dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.62954005
99base-excision repair, AP site formation (GO:0006285)2.62283701
100dopamine transport (GO:0015872)2.61721401
101male meiosis (GO:0007140)2.61477410
102meiotic cell cycle (GO:0051321)2.61470694
103negative regulation of telomere maintenance (GO:0032205)2.59977356
104response to peptidoglycan (GO:0032494)2.58448170
105regulation of ubiquitin-protein transferase activity (GO:0051438)2.57231054
106regulation of meiosis I (GO:0060631)2.57117591
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55573339
108positive regulation of mitochondrial fission (GO:0090141)2.55345362
109histone exchange (GO:0043486)2.55171059
110response to interferon-beta (GO:0035456)2.54746733
111response to pheromone (GO:0019236)2.53225750
112regulation of cellular amine metabolic process (GO:0033238)2.52908214
113protein-cofactor linkage (GO:0018065)2.52248483
114cellular response to gamma radiation (GO:0071480)2.50871476
115antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.50685883
116negative regulation of protein ubiquitination (GO:0031397)2.50344840
117regulation of ligase activity (GO:0051340)2.49875807
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49064788
119anterograde synaptic vesicle transport (GO:0048490)2.48675422
120rRNA methylation (GO:0031167)2.48572961
121spindle checkpoint (GO:0031577)2.48437294
122exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.47742214
123ribosome biogenesis (GO:0042254)2.46922176
124negative regulation of ligase activity (GO:0051352)2.46558246
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.46558246
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.45787095
127positive regulation of protein import into nucleus, translocation (GO:0033160)2.45302263
128peptidyl-histidine modification (GO:0018202)2.45108083
129xenobiotic catabolic process (GO:0042178)2.44988312
130regulation of integrin-mediated signaling pathway (GO:2001044)2.44518072
131pseudouridine synthesis (GO:0001522)2.43850778
132single fertilization (GO:0007338)2.43841867
133regulation of spindle checkpoint (GO:0090231)2.43800589
134protein targeting to mitochondrion (GO:0006626)2.43600191
135modulation by virus of host process (GO:0019054)2.43384352
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.43230595
137signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.43230595
138signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43230595
139negative regulation of signal transduction by p53 class mediator (GO:1901797)2.43111353
140DNA damage induced protein phosphorylation (GO:0006975)2.43056955
141kinetochore organization (GO:0051383)2.42143959
142positive regulation of cAMP-mediated signaling (GO:0043950)2.41770521
143synapsis (GO:0007129)2.40872204
144termination of RNA polymerase III transcription (GO:0006386)2.40113151
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.40113151
146reactive oxygen species biosynthetic process (GO:1903409)2.39287706
147intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.39226942
148signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.39226942
149negative regulation of viral genome replication (GO:0045071)2.38960819
150negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.38958536
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38915307
152pyrimidine nucleotide catabolic process (GO:0006244)2.38315144
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.37988661
154microtubule polymerization or depolymerization (GO:0031109)2.37981295
155regulation of mitotic spindle checkpoint (GO:1903504)2.37766397
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37766397
157negative regulation of meiosis (GO:0045835)2.37694664
158DNA replication checkpoint (GO:0000076)2.37630129
159protein localization to chromosome, centromeric region (GO:0071459)2.37504067
160single strand break repair (GO:0000012)2.36485253
161positive regulation of ligase activity (GO:0051351)2.35992289
162metallo-sulfur cluster assembly (GO:0031163)2.35236956
163iron-sulfur cluster assembly (GO:0016226)2.35236956
164negative regulation of sister chromatid segregation (GO:0033046)2.34531497
165negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34531497

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.48458640
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.70831840
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51458499
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.45229070
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35914146
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.98053546
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.93894357
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88028611
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.67157959
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.61046473
11ZNF274_21170338_ChIP-Seq_K562_Hela2.60756231
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54811528
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.45185126
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33665515
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.28634409
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.27048731
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25548902
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.21328109
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19085592
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18248969
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04302922
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.97456976
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96490993
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92368423
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90745533
26VDR_23849224_ChIP-Seq_CD4+_Human1.90696933
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89592212
28* ETS1_20019798_ChIP-Seq_JURKAT_Human1.88781190
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86162961
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84146293
31EWS_26573619_Chip-Seq_HEK293_Human1.83180020
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78634002
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78618705
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76552641
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75622035
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75496195
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75441393
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69486231
39* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68449573
40* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67582489
41GBX2_23144817_ChIP-Seq_PC3_Human1.65317364
42* YY1_21170310_ChIP-Seq_MESCs_Mouse1.62905569
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.62824346
44P300_19829295_ChIP-Seq_ESCs_Human1.60510578
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59053485
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56008308
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49474213
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.48652996
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47449401
50ELK1_19687146_ChIP-ChIP_HELA_Human1.46671105
51HTT_18923047_ChIP-ChIP_STHdh_Human1.46151382
52SOX2_19829295_ChIP-Seq_ESCs_Human1.44458270
53NANOG_19829295_ChIP-Seq_ESCs_Human1.44458270
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.42979608
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42841339
56TP53_22573176_ChIP-Seq_HFKS_Human1.42005162
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40934901
58BCAT_22108803_ChIP-Seq_LS180_Human1.40189736
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39891652
60FOXP3_21729870_ChIP-Seq_TREG_Human1.39532472
61FUS_26573619_Chip-Seq_HEK293_Human1.38236721
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36987044
63DCP1A_22483619_ChIP-Seq_HELA_Human1.34265075
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33875673
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32359004
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32097522
67GABP_19822575_ChIP-Seq_HepG2_Human1.32056998
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30063391
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29526640
70ER_23166858_ChIP-Seq_MCF-7_Human1.29180801
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29058350
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29049509
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28883040
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28260373
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26434771
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25752002
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25337288
78RBPJ_21746931_ChIP-Seq_IB4_Human1.23820249
79PHF8_20622853_ChIP-Seq_HELA_Human1.23349613
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22570933
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21858271
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.20791264
83* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20257437
84* TTF2_22483619_ChIP-Seq_HELA_Human1.19533237
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19316658
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18607423
87SALL4_22934838_ChIP-ChIP_CD34+_Human1.17313231
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16894522
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16849452
90AR_21909140_ChIP-Seq_LNCAP_Human1.16757638
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16183917
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15780279
93GATA6_21074721_ChIP-Seq_CACO-2_Human1.15274158
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14556679
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.14556679
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14311955
97CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14289822
98* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14256759
99SPI1_23547873_ChIP-Seq_NB4_Human1.14214063
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13885750
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13818988
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.13551986
103AR_20517297_ChIP-Seq_VCAP_Human1.12185941
104* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10153449
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09718329
106TAF15_26573619_Chip-Seq_HEK293_Human1.08225739
107HNFA_21074721_ChIP-Seq_CACO-2_Human1.07387922
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06748129
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06316073
110VDR_22108803_ChIP-Seq_LS180_Human1.06107343
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04321478
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03670191
113* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01878651
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01877863
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01675702
116* XRN2_22483619_ChIP-Seq_HELA_Human1.01319801
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01194841
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01046990
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00178357
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00095953
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00095953
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00095953
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.99830752
124NFYA_21822215_ChIP-Seq_K562_Human0.99505540
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99306484
126NFYB_21822215_ChIP-Seq_K562_Human0.99121951
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98862027
128NCOR_22424771_ChIP-Seq_293T_Human0.98314909
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97125852
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96455249
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96389035
132* P53_22387025_ChIP-Seq_ESCs_Mouse0.96165496
133* STAT3_18555785_Chip-Seq_ESCs_Mouse0.95558317
134TCF4_22108803_ChIP-Seq_LS180_Human0.95528769
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.95500916
136* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95337213
137* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94693270
138MYC_18940864_ChIP-ChIP_HL60_Human0.94163094
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.93910029
140ETV1_20927104_ChIP-Seq_GIST48_Human0.93561142
141* E2F1_18555785_Chip-Seq_ESCs_Mouse0.93463754
142NANOG_20526341_ChIP-Seq_ESCs_Human0.93078090
143CDX2_22108803_ChIP-Seq_LS180_Human0.92917000
144* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92913888
145AR_25329375_ChIP-Seq_VCAP_Human0.92795721
146* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91095476
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91019186
148KDM5A_27292631_Chip-Seq_BREAST_Human0.90434184
149TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90410948
150NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89051673
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88121539
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87909826
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85772344
154RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84874707
155* STAT1_17558387_ChIP-Seq_HELA_Human0.84088175
156IRF8_27001747_Chip-Seq_BMDM_Mouse0.83646965
157EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83557756
158E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83474405
159TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83075302
160MYB_26560356_Chip-Seq_TH1_Human0.83029771
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82344064
162TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81370602
163* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80893144
164CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79254544
165* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79017463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.79514196
2MP0003718_maternal_effect3.56130935
3MP0003693_abnormal_embryo_hatching3.42422357
4MP0005451_abnormal_body_composition2.75505710
5MP0000372_irregular_coat_pigmentation2.69499011
6MP0003646_muscle_fatigue2.59791988
7MP0010094_abnormal_chromosome_stability2.44979683
8MP0005367_renal/urinary_system_phenotyp2.40610886
9MP0000516_abnormal_urinary_system2.40610886
10MP0003077_abnormal_cell_cycle2.39065105
11MP0002102_abnormal_ear_morphology2.36701879
12MP0003111_abnormal_nucleus_morphology2.33229328
13MP0008260_abnormal_autophagy2.33188509
14MP0005084_abnormal_gallbladder_morpholo2.29248783
15MP0001835_abnormal_antigen_presentation2.28755506
16MP0006292_abnormal_olfactory_placode2.27845540
17MP0003011_delayed_dark_adaptation2.17192340
18MP0009785_altered_susceptibility_to2.16183052
19MP0003186_abnormal_redox_activity2.13869464
20MP0006036_abnormal_mitochondrial_physio2.13759348
21MP0002736_abnormal_nociception_after2.07916048
22MP0005379_endocrine/exocrine_gland_phen2.04760034
23MP0004957_abnormal_blastocyst_morpholog2.03928838
24MP0004782_abnormal_surfactant_physiolog2.03485988
25MP0002138_abnormal_hepatobiliary_system2.01802269
26MP0008058_abnormal_DNA_repair2.01492375
27MP0002837_dystrophic_cardiac_calcinosis1.98018741
28MP0008007_abnormal_cellular_replicative1.94178893
29MP0001119_abnormal_female_reproductive1.87496735
30MP0002653_abnormal_ependyma_morphology1.86854116
31MP0005410_abnormal_fertilization1.78363474
32MP0005671_abnormal_response_to1.75139888
33MP0001929_abnormal_gametogenesis1.71817693
34MP0008877_abnormal_DNA_methylation1.71726630
35MP0006054_spinal_hemorrhage1.71627045
36MP0002132_abnormal_respiratory_system1.71216190
37MP0002277_abnormal_respiratory_mucosa1.70035751
38MP0003786_premature_aging1.69305689
39* MP0002210_abnormal_sex_determination1.68237873
40MP0006072_abnormal_retinal_apoptosis1.67941601
41MP0004142_abnormal_muscle_tone1.65820276
42MP0008789_abnormal_olfactory_epithelium1.61499649
43MP0003950_abnormal_plasma_membrane1.59051556
44MP0005551_abnormal_eye_electrophysiolog1.57817187
45MP0003436_decreased_susceptibility_to1.55794029
46MP0008932_abnormal_embryonic_tissue1.51358217
47MP0005408_hypopigmentation1.46566119
48MP0001529_abnormal_vocalization1.44102031
49MP0008057_abnormal_DNA_replication1.43940381
50MP0002163_abnormal_gland_morphology1.42755149
51MP0003763_abnormal_thymus_physiology1.42212019
52MP0003941_abnormal_skin_development1.41866684
53MP0001968_abnormal_touch/_nociception1.41820529
54MP0006035_abnormal_mitochondrial_morpho1.40159281
55MP0003787_abnormal_imprinting1.38594939
56MP0005253_abnormal_eye_physiology1.36865899
57* MP0000653_abnormal_sex_gland1.36535271
58MP0008872_abnormal_physiological_respon1.34344876
59MP0001764_abnormal_homeostasis1.30949263
60MP0005395_other_phenotype1.30475461
61MP0002877_abnormal_melanocyte_morpholog1.30118925
62MP0006276_abnormal_autonomic_nervous1.29804616
63MP0005646_abnormal_pituitary_gland1.27843976
64MP0002148_abnormal_hypersensitivity_rea1.27718450
65MP0001919_abnormal_reproductive_system1.26661244
66MP0000685_abnormal_immune_system1.25971096
67MP0003699_abnormal_female_reproductive1.23936408
68MP0003724_increased_susceptibility_to1.23906582
69MP0005025_abnormal_response_to1.23873735
70MP0008004_abnormal_stomach_pH1.23441316
71MP0002419_abnormal_innate_immunity1.22627179
72MP0003806_abnormal_nucleotide_metabolis1.22099767
73MP0000427_abnormal_hair_cycle1.21939349
74MP0006082_CNS_inflammation1.20881567
75MP0005387_immune_system_phenotype1.20779942
76MP0001790_abnormal_immune_system1.20779942
77MP0002938_white_spotting1.20768534
78MP0005000_abnormal_immune_tolerance1.20517515
79MP0001756_abnormal_urination1.20289244
80MP0004808_abnormal_hematopoietic_stem1.19332630
81MP0000678_abnormal_parathyroid_gland1.18692586
82MP0000490_abnormal_crypts_of1.16889905
83MP0002693_abnormal_pancreas_physiology1.16596837
84MP0001905_abnormal_dopamine_level1.15076381
85MP0002452_abnormal_antigen_presenting1.13332176
86MP0002751_abnormal_autonomic_nervous1.13259519
87MP0005075_abnormal_melanosome_morpholog1.11217118
88* MP0001145_abnormal_male_reproductive1.11101994
89MP0002723_abnormal_immune_serum1.10885889
90MP0005332_abnormal_amino_acid1.09609021
91MP0005389_reproductive_system_phenotype1.08765590
92MP0010386_abnormal_urinary_bladder1.07890672
93MP0002398_abnormal_bone_marrow1.07726182
94MP0002909_abnormal_adrenal_gland1.06540794
95MP0001346_abnormal_lacrimal_gland1.06112455
96MP0000566_synostosis1.05948418
97MP0003136_yellow_coat_color1.05667072
98MP0005220_abnormal_exocrine_pancreas1.05506086
99MP0001800_abnormal_humoral_immune1.04138890
100MP0005499_abnormal_olfactory_system1.03115645
101MP0005394_taste/olfaction_phenotype1.03115645
102MP0003698_abnormal_male_reproductive1.02387416
103MP0005174_abnormal_tail_pigmentation1.02330728
104MP0001819_abnormal_immune_cell1.02114018
105MP0004215_abnormal_myocardial_fiber1.01263200
106MP0000230_abnormal_systemic_arterial1.00068201
107MP0000749_muscle_degeneration0.99996425
108MP0002420_abnormal_adaptive_immunity0.99788685
109MP0003279_aneurysm0.97597702
110MP0001545_abnormal_hematopoietic_system0.97444942
111MP0005397_hematopoietic_system_phenotyp0.97444942
112MP0000358_abnormal_cell_content/0.96757183
113MP0000716_abnormal_immune_system0.94501992
114* MP0000689_abnormal_spleen_morphology0.94091218
115MP0002161_abnormal_fertility/fecundity0.92580341
116MP0009697_abnormal_copulation0.91884397
117MP0002019_abnormal_tumor_incidence0.91251832
118MP0002234_abnormal_pharynx_morphology0.90472421
119MP0010155_abnormal_intestine_physiology0.90133157
120MP0004019_abnormal_vitamin_homeostasis0.90025197
121MP0003121_genomic_imprinting0.89686210
122MP0000313_abnormal_cell_death0.89232401
123MP0005647_abnormal_sex_gland0.89177856
124MP0001944_abnormal_pancreas_morphology0.88877483
125MP0003315_abnormal_perineum_morphology0.88241558
126MP0002160_abnormal_reproductive_system0.88188512
127MP0005083_abnormal_biliary_tract0.87873084
128MP0000350_abnormal_cell_proliferation0.87577981
129MP0010030_abnormal_orbit_morphology0.87263900
130MP0005636_abnormal_mineral_homeostasis0.87095438
131MP0009840_abnormal_foam_cell0.86794338
132MP0009333_abnormal_splenocyte_physiolog0.85944696
133MP0008995_early_reproductive_senescence0.85063212
134MP0002254_reproductive_system_inflammat0.84525042
135MP0008469_abnormal_protein_level0.84414026
136* MP0002722_abnormal_immune_system0.83520991
137MP0002405_respiratory_system_inflammati0.82867920
138MP0002429_abnormal_blood_cell0.82675138
139MP0001984_abnormal_olfaction0.82621580
140MP0003943_abnormal_hepatobiliary_system0.82503761
141MP0001661_extended_life_span0.82143837
142MP0009764_decreased_sensitivity_to0.80600599
143MP0002168_other_aberrant_phenotype0.80530311
144MP0000465_gastrointestinal_hemorrhage0.79868634
145MP0002009_preneoplasia0.79794147
146MP0005464_abnormal_platelet_physiology0.79762405
147MP0000538_abnormal_urinary_bladder0.77658288
148MP0001542_abnormal_bone_strength0.77363885
149MP0001845_abnormal_inflammatory_respons0.76560869
150MP0001915_intracranial_hemorrhage0.75086851
151MP0005535_abnormal_body_temperature0.73771331
152MP0008875_abnormal_xenobiotic_pharmacok0.73176452
153MP0000049_abnormal_middle_ear0.72933798
154MP0000631_abnormal_neuroendocrine_gland0.72659195
155MP0001986_abnormal_taste_sensitivity0.72515069
156MP0000613_abnormal_salivary_gland0.71533559
157MP0005310_abnormal_salivary_gland0.70831919
158MP0002638_abnormal_pupillary_reflex0.70383885
159MP0002090_abnormal_vision0.70358748
160MP0002928_abnormal_bile_duct0.69819246
161MP0008775_abnormal_heart_ventricle0.68970245
162MP0001727_abnormal_embryo_implantation0.68667312

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.40123538
2Progressive macrocephaly (HP:0004481)4.14362821
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.11177650
4Acute encephalopathy (HP:0006846)3.96482710
5Mitochondrial inheritance (HP:0001427)3.89151695
6Chromsome breakage (HP:0040012)3.83901603
7Degeneration of anterior horn cells (HP:0002398)3.68390420
8Abnormality of the anterior horn cell (HP:0006802)3.68390420
9Abnormal mitochondria in muscle tissue (HP:0008316)3.68017489
10Increased CSF lactate (HP:0002490)3.63699578
11Hepatic necrosis (HP:0002605)3.49341644
12Hepatocellular necrosis (HP:0001404)3.45254745
13Recurrent abscess formation (HP:0002722)3.32477948
14Recurrent bacterial skin infections (HP:0005406)3.14487045
15Type 2 muscle fiber atrophy (HP:0003554)3.13713210
16Eczematoid dermatitis (HP:0000976)3.11860557
17Prolonged bleeding time (HP:0003010)3.00813087
18Dyschromatopsia (HP:0007641)2.98762206
19Optic neuritis (HP:0100653)2.98087617
20Retrobulbar optic neuritis (HP:0100654)2.98087617
21Renal Fanconi syndrome (HP:0001994)2.96887178
22Methylmalonic acidemia (HP:0002912)2.89029148
23Increased hepatocellular lipid droplets (HP:0006565)2.83219381
24Abnormality of midbrain morphology (HP:0002418)2.81848983
25Molar tooth sign on MRI (HP:0002419)2.81848983
26Breast hypoplasia (HP:0003187)2.80732293
27Hypothermia (HP:0002045)2.79932984
28Increased IgM level (HP:0003496)2.71561867
29Pancreatic cysts (HP:0001737)2.69318494
30Muscle fiber atrophy (HP:0100295)2.65799044
31Abnormal rod and cone electroretinograms (HP:0008323)2.65730322
32Impulsivity (HP:0100710)2.64708499
33Meckel diverticulum (HP:0002245)2.62443576
34Pancreatic fibrosis (HP:0100732)2.59740612
35Clubbing of toes (HP:0100760)2.58083929
36Cerebral edema (HP:0002181)2.57778272
37Irregular epiphyses (HP:0010582)2.56831753
38Adrenal hypoplasia (HP:0000835)2.55221706
39Birth length less than 3rd percentile (HP:0003561)2.54138940
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.53571156
41Methylmalonic aciduria (HP:0012120)2.53302058
42Intestinal atresia (HP:0011100)2.51242446
43Abnormality of the preputium (HP:0100587)2.51076544
44Lipid accumulation in hepatocytes (HP:0006561)2.50200970
45Autoimmune thrombocytopenia (HP:0001973)2.49406422
46Orchitis (HP:0100796)2.47335885
47Hypergonadotropic hypogonadism (HP:0000815)2.45902684
48Bone marrow hypocellularity (HP:0005528)2.44466107
49Abnormality of the ileum (HP:0001549)2.43402630
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43305720
51Stomatitis (HP:0010280)2.41938401
52Alveolar cell carcinoma (HP:0006519)2.41715015
53Flat capital femoral epiphysis (HP:0003370)2.41699859
54Mediastinal lymphadenopathy (HP:0100721)2.37086589
55Respiratory failure (HP:0002878)2.36347623
56Medial flaring of the eyebrow (HP:0010747)2.35822832
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.35610068
58Male infertility (HP:0003251)2.35342342
59Generalized aminoaciduria (HP:0002909)2.34474698
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33052976
61Prolonged neonatal jaundice (HP:0006579)2.30665348
62Abnormal pupillary function (HP:0007686)2.30349183
63Exertional dyspnea (HP:0002875)2.27759982
64Optic disc pallor (HP:0000543)2.27254539
65Abnormality of renal resorption (HP:0011038)2.26987790
66Abnormal lung lobation (HP:0002101)2.24793664
67Type I transferrin isoform profile (HP:0003642)2.24283781
68Lactic acidosis (HP:0003128)2.23442973
69Hyperlipoproteinemia (HP:0010980)2.22433808
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22066295
71Aplasia/Hypoplasia of the patella (HP:0006498)2.21106330
72Abnormality of methionine metabolism (HP:0010901)2.18695686
73Congenital, generalized hypertrichosis (HP:0004540)2.18295940
74Abnormality of the labia minora (HP:0012880)2.18016152
75Patellar aplasia (HP:0006443)2.17852911
76Abnormality of chromosome stability (HP:0003220)2.14934782
77Premature ovarian failure (HP:0008209)2.14294347
78Myositis (HP:0100614)2.14204657
79Male pseudohermaphroditism (HP:0000037)2.14126192
80Abolished electroretinogram (ERG) (HP:0000550)2.13204517
81Hypoglycemic coma (HP:0001325)2.12769868
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12150175
83Neoplasm of the tracheobronchial system (HP:0100552)2.11715527
84Duodenal stenosis (HP:0100867)2.08081165
85Small intestinal stenosis (HP:0012848)2.08081165
86Tongue fasciculations (HP:0001308)2.05655278
87Increased serum lactate (HP:0002151)2.04026589
883-Methylglutaconic aciduria (HP:0003535)2.01731573
89Glycosuria (HP:0003076)2.00999029
90Abnormality of urine glucose concentration (HP:0011016)2.00999029
91Nephroblastoma (Wilms tumor) (HP:0002667)1.99568039
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99414960
93Hypoplasia of the fovea (HP:0007750)1.98695818
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.98695818
95Lethargy (HP:0001254)1.98443272
96Pancreatic islet-cell hyperplasia (HP:0004510)1.98394824
97Congenital stationary night blindness (HP:0007642)1.98199256
98Breast aplasia (HP:0100783)1.97292338
99Keratoconjunctivitis sicca (HP:0001097)1.94547572
100Disproportionate short-trunk short stature (HP:0003521)1.94214024
101Abnormality of the femoral head (HP:0003368)1.93191586
102Aplasia/Hypoplasia of the breasts (HP:0010311)1.92513221
103Aplasia/Hypoplasia of the tongue (HP:0010295)1.90874805
104Nausea (HP:0002018)1.90473660
105Abnormality of vitamin B metabolism (HP:0004340)1.90374823
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88977036
107Recurrent gram-negative bacterial infections (HP:0005420)1.88711738
108Rough bone trabeculation (HP:0100670)1.88296106
109Embryonal renal neoplasm (HP:0011794)1.88063889
110Aplastic anemia (HP:0001915)1.87617053
111Keratoconjunctivitis (HP:0001096)1.87281187
112True hermaphroditism (HP:0010459)1.86873363
113Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85774849
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84905090
115Abnormal protein N-linked glycosylation (HP:0012347)1.84905090
116Abnormal protein glycosylation (HP:0012346)1.84905090
117Abnormal glycosylation (HP:0012345)1.84905090
118Attenuation of retinal blood vessels (HP:0007843)1.84638999
119Hypoproteinemia (HP:0003075)1.84417238
120Decreased central vision (HP:0007663)1.84086325
121Abnormality of the proximal phalanges of the hand (HP:0009834)1.84085868
122Abnormal spermatogenesis (HP:0008669)1.83935323
123Myelodysplasia (HP:0002863)1.83885695
124Recurrent skin infections (HP:0001581)1.83595896
125Muscle fibrillation (HP:0010546)1.83490858
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83139794
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83139794
128Carpal bone hypoplasia (HP:0001498)1.83111478
129Abnormality of the phalanges of the 5th finger (HP:0004213)1.82601907
130Prostate neoplasm (HP:0100787)1.82104454
131Pulmonary fibrosis (HP:0002206)1.81547192
132Increased mean platelet volume (HP:0011877)1.81458143
133Weak cry (HP:0001612)1.80892203
134Respiratory difficulties (HP:0002880)1.80251931
135Osteomalacia (HP:0002749)1.80218100
136Abnormal hair whorl (HP:0010721)1.80166236
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.80164702
138Absent/shortened dynein arms (HP:0200106)1.80164702
139Hyperinsulinemic hypoglycemia (HP:0000825)1.78941467
140Nephronophthisis (HP:0000090)1.78113898
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77396652
142Abnormality of the renal cortex (HP:0011035)1.77216522
143Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77132229
144Poor suck (HP:0002033)1.76941098
145Menorrhagia (HP:0000132)1.76590277
146Encephalitis (HP:0002383)1.76393769
147Exercise intolerance (HP:0003546)1.75745153
148Ectopic kidney (HP:0000086)1.75573623
149Sclerocornea (HP:0000647)1.75228536
150CNS demyelination (HP:0007305)1.74641862
151Hypomagnesemia (HP:0002917)1.74108447
152Recurrent fungal infections (HP:0002841)1.73291210
153Oral leukoplakia (HP:0002745)1.72947870
154Abnormal platelet volume (HP:0011876)1.72184925
155Large for gestational age (HP:0001520)1.71876769
156Petechiae (HP:0000967)1.70476143
157Reduced antithrombin III activity (HP:0001976)1.70390872
158Infertility (HP:0000789)1.69729682
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.69709085
160Absent epiphyses (HP:0010577)1.69709085
161Sloping forehead (HP:0000340)1.68498878
162Conjunctival hamartoma (HP:0100780)1.68092260
163Abnormal trabecular bone morphology (HP:0100671)1.67781453
164Severe visual impairment (HP:0001141)1.67432210
165Abnormality of the epiphysis of the femoral head (HP:0010574)1.67387019
166Proximal tubulopathy (HP:0000114)1.66890012
167Constricted visual fields (HP:0001133)1.66250673
168Abnormality of incisor morphology (HP:0011063)1.65713043
169Joint swelling (HP:0001386)1.65044859
170Abnormality of the heme biosynthetic pathway (HP:0010472)1.63678717
171Abnormality of the prostate (HP:0008775)1.63535439
172Purpura (HP:0000979)1.63265237
173Neoplasm of the adrenal gland (HP:0100631)1.63261711
174Lip pit (HP:0100267)1.63102694
175Abnormality of endocrine pancreas physiology (HP:0012093)1.62672691
176Abnormality of the pancreatic islet cells (HP:0006476)1.62672691
177Osteomyelitis (HP:0002754)1.62597009
178Abnormal respiratory motile cilium morphology (HP:0005938)1.62336736
179Abnormal respiratory epithelium morphology (HP:0012253)1.62336736
180Metaphyseal irregularity (HP:0003025)1.62133922
181Abnormality of the duodenum (HP:0002246)1.61845697
182Aplasia/Hypoplasia of the macula (HP:0008059)1.61763859
183Cleft eyelid (HP:0000625)1.61713502
184Abnormal biliary tract physiology (HP:0012439)1.61426658
185Abnormality of the fovea (HP:0000493)1.60827069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.49532296
2FRK3.42895838
3BUB13.10933530
4STK38L2.90398378
5INSRR2.87682442
6AKT32.84019099
7IRAK42.68696025
8MAP4K22.59638909
9PLK42.52126392
10MAP3K142.50206884
11WNK32.40443663
12VRK22.38799548
13EIF2AK12.31482875
14BRAF2.21952490
15MKNK12.20923122
16MUSK2.20248039
17MKNK22.17038945
18TNIK2.04409252
19ZAK1.95599573
20TESK11.88207485
21ADRBK21.85786135
22BMPR21.82740044
23BRSK21.78212024
24EIF2AK21.74169514
25PIM21.72305992
26IKBKE1.66164505
27STK241.65967825
28CCNB11.64157057
29GRK11.61871502
30NME11.59241163
31MAP3K121.59016998
32ERBB41.58723517
33NUAK11.58490838
34WEE11.58018972
35EPHA31.56047868
36TTK1.55547734
37TXK1.42451226
38TYK21.39987910
39PLK11.36687237
40SRPK11.34197331
41PIM11.28657117
42ERN11.28562272
43IKBKB1.28390006
44MYLK1.27973116
45EPHB11.27489974
46ACVR1B1.26792015
47STK101.26032886
48OXSR11.22952686
49PLK21.21427511
50BCR1.20696085
51MAP2K31.20629479
52IRAK31.19021394
53PLK31.17554296
54PAK31.17338745
55FGFR21.13735816
56STK41.13519337
57STK161.11988548
58CHUK1.11479871
59MAPK131.10365282
60TRPM71.05997134
61SGK21.02982030
62NLK1.01494716
63CLK11.00840476
64TNK21.00489646
65MST40.99204711
66PTK2B0.98799864
67CHEK20.98259500
68PDK30.97603036
69PDK40.97603036
70VRK10.97365822
71DYRK20.96331657
72PINK10.93553203
73STK30.93241213
74MAPKAPK30.91914423
75CDK80.90955195
76IRAK10.89206305
77FER0.88691912
78PHKG20.87720654
79PHKG10.87720654
80EIF2AK30.86110944
81BMPR1B0.86010553
82NEK60.85875989
83TLK10.85596451
84MAP2K60.84279346
85OBSCN0.83832315
86ARAF0.82469634
87FGFR30.80526705
88YES10.80292621
89CSNK1G10.79806103
90PBK0.79659565
91PDK20.79298859
92TBK10.77994969
93BRSK10.77485287
94CDK70.77070630
95TAOK30.76814611
96NEK20.76649758
97GRK50.76125736
98TEC0.74880463
99CSNK1G30.72665141
100PRKCE0.72161515
101ERBB30.68456954
102JAK30.67789305
103AURKA0.66993056
104MAP3K30.66934074
105SIK30.65371746
106AURKB0.65177337
107TESK20.64938065
108GRK70.64702050
109MAP4K10.64617278
110PASK0.64510899
111PRKCI0.62157932
112MAP3K80.61797828
113BCKDK0.61379551
114CSNK1G20.60410200
115MELK0.60372121
116ADRBK10.59836825
117JAK10.59012063
118EPHA20.57895603
119RIPK40.56348176
120BTK0.53638644
121PRPF4B0.53409328
122ZAP700.51977371
123MARK30.50770616
124MAP3K60.50461021
125KDR0.49438264
126MAPKAPK20.47499018
127ATR0.47289516
128PRKCG0.46557242
129SGK4940.45555244
130SGK2230.45555244
131DAPK10.44882716
132CSNK2A10.44429447
133MAP3K40.44403081
134PAK10.43566453
135MINK10.43303482
136DYRK30.43166272
137PRKD30.42233267
138ILK0.41475895
139LATS20.40670470
140LIMK10.40097174
141ABL20.39900409
142MAP2K70.38439522
143PKN10.38354105
144TAF10.38148012
145MAP3K110.36083035
146PRKG10.35795239
147SYK0.35469750
148LYN0.33799596
149PRKCQ0.33749992
150TSSK60.32508267
151ROCK10.31665079
152STK390.30426012
153TIE10.27992994
154MAP3K50.27525890
155FES0.27330898
156PRKACA0.26315660

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.65994358
2Parkinsons disease_Homo sapiens_hsa050123.05258058
3Proteasome_Homo sapiens_hsa030502.97021126
4RNA polymerase_Homo sapiens_hsa030202.79446651
5DNA replication_Homo sapiens_hsa030302.72561951
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60203537
7Basal transcription factors_Homo sapiens_hsa030222.47837233
8Homologous recombination_Homo sapiens_hsa034402.46197486
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42587985
10Base excision repair_Homo sapiens_hsa034102.42113721
11Fatty acid elongation_Homo sapiens_hsa000622.23263703
12RNA degradation_Homo sapiens_hsa030182.17796864
13Fanconi anemia pathway_Homo sapiens_hsa034602.13140749
14Collecting duct acid secretion_Homo sapiens_hsa049662.10824438
15Cell cycle_Homo sapiens_hsa041102.07422642
16Graft-versus-host disease_Homo sapiens_hsa053321.96939728
17Mismatch repair_Homo sapiens_hsa034301.96481783
18Vitamin B6 metabolism_Homo sapiens_hsa007501.96358793
19Pyrimidine metabolism_Homo sapiens_hsa002401.87902036
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86118730
21RNA transport_Homo sapiens_hsa030131.80860328
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74718742
23Nucleotide excision repair_Homo sapiens_hsa034201.71244129
24Alzheimers disease_Homo sapiens_hsa050101.66828487
25Allograft rejection_Homo sapiens_hsa053301.65236157
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.63217999
27Sulfur metabolism_Homo sapiens_hsa009201.59550290
28Phototransduction_Homo sapiens_hsa047441.59450196
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58573264
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.53932371
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52284801
32Propanoate metabolism_Homo sapiens_hsa006401.47821475
33Measles_Homo sapiens_hsa051621.41267512
34Spliceosome_Homo sapiens_hsa030401.41102832
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40797009
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40235865
37Nitrogen metabolism_Homo sapiens_hsa009101.39664087
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.39237249
39Herpes simplex infection_Homo sapiens_hsa051681.37339317
40Protein export_Homo sapiens_hsa030601.36413122
41Purine metabolism_Homo sapiens_hsa002301.34772400
42One carbon pool by folate_Homo sapiens_hsa006701.34600142
43p53 signaling pathway_Homo sapiens_hsa041151.33077999
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29679957
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26137610
46Legionellosis_Homo sapiens_hsa051341.24589786
47Type I diabetes mellitus_Homo sapiens_hsa049401.24370018
48Butanoate metabolism_Homo sapiens_hsa006501.15989670
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15725213
50Autoimmune thyroid disease_Homo sapiens_hsa053201.14218585
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13508622
52Primary immunodeficiency_Homo sapiens_hsa053401.12725152
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12613530
54Steroid biosynthesis_Homo sapiens_hsa001001.11293353
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07746238
56Influenza A_Homo sapiens_hsa051641.06946347
57Asthma_Homo sapiens_hsa053101.05786601
58Leishmaniasis_Homo sapiens_hsa051401.04799648
59mRNA surveillance pathway_Homo sapiens_hsa030151.04582188
60Folate biosynthesis_Homo sapiens_hsa007901.04411100
61Arachidonic acid metabolism_Homo sapiens_hsa005901.02824399
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02750400
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00808697
64Epstein-Barr virus infection_Homo sapiens_hsa051690.98660261
65Non-homologous end-joining_Homo sapiens_hsa034500.98125150
66Malaria_Homo sapiens_hsa051440.96728127
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95311008
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95257037
69Glutathione metabolism_Homo sapiens_hsa004800.94733841
70beta-Alanine metabolism_Homo sapiens_hsa004100.94022253
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92079402
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89091299
73Tryptophan metabolism_Homo sapiens_hsa003800.82963728
74Caffeine metabolism_Homo sapiens_hsa002320.82422624
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.81036985
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80734435
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80327512
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79484643
79Hematopoietic cell lineage_Homo sapiens_hsa046400.77046587
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.75361003
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.74284910
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71752170
83Chemical carcinogenesis_Homo sapiens_hsa052040.71600950
84Ribosome_Homo sapiens_hsa030100.71325564
85Staphylococcus aureus infection_Homo sapiens_hsa051500.70321055
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70244409
87Retinol metabolism_Homo sapiens_hsa008300.68883262
88Shigellosis_Homo sapiens_hsa051310.68629791
89Antigen processing and presentation_Homo sapiens_hsa046120.68556325
90Regulation of autophagy_Homo sapiens_hsa041400.66551298
91Cardiac muscle contraction_Homo sapiens_hsa042600.66132314
92Peroxisome_Homo sapiens_hsa041460.65992037
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65801207
94Pentose phosphate pathway_Homo sapiens_hsa000300.65654178
95Linoleic acid metabolism_Homo sapiens_hsa005910.65069886
96Olfactory transduction_Homo sapiens_hsa047400.64913351
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.64183250
98Galactose metabolism_Homo sapiens_hsa000520.63694956
99Apoptosis_Homo sapiens_hsa042100.63269908
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62597686
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62044943
102Huntingtons disease_Homo sapiens_hsa050160.61437552
103Vibrio cholerae infection_Homo sapiens_hsa051100.61324103
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60493650
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56590354
106Rheumatoid arthritis_Homo sapiens_hsa053230.56391750
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56291093
108Ether lipid metabolism_Homo sapiens_hsa005650.56138644
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55606323
110Thyroid cancer_Homo sapiens_hsa052160.53198275
111Oocyte meiosis_Homo sapiens_hsa041140.52911847
112Ovarian steroidogenesis_Homo sapiens_hsa049130.51694849
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51087582
114HTLV-I infection_Homo sapiens_hsa051660.50210311
115Selenocompound metabolism_Homo sapiens_hsa004500.49855152
116Pertussis_Homo sapiens_hsa051330.49154560
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48801754
118TGF-beta signaling pathway_Homo sapiens_hsa043500.47993784
119Toxoplasmosis_Homo sapiens_hsa051450.46676570
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46035649
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45005336
122Hepatitis B_Homo sapiens_hsa051610.44928006
123Sphingolipid metabolism_Homo sapiens_hsa006000.43558416
124Hepatitis C_Homo sapiens_hsa051600.40842737
125Fructose and mannose metabolism_Homo sapiens_hsa000510.40779818
126Arginine and proline metabolism_Homo sapiens_hsa003300.35861325
127TNF signaling pathway_Homo sapiens_hsa046680.35587937
128Phagosome_Homo sapiens_hsa041450.35283852
129Metabolic pathways_Homo sapiens_hsa011000.35217938
130Pyruvate metabolism_Homo sapiens_hsa006200.33546173
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.33203243
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30724313
133Platelet activation_Homo sapiens_hsa046110.30655580
134N-Glycan biosynthesis_Homo sapiens_hsa005100.26789576
135Circadian rhythm_Homo sapiens_hsa047100.22413718
136Fatty acid degradation_Homo sapiens_hsa000710.22037939

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