DDX60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.21422749
2type I interferon signaling pathway (GO:0060337)6.03732155
3cellular response to type I interferon (GO:0071357)6.03732155
4response to type I interferon (GO:0034340)6.01205970
5positive regulation of interferon-alpha production (GO:0032727)5.62609040
6response to interferon-alpha (GO:0035455)5.54800559
7regulation of interferon-alpha production (GO:0032647)5.29068438
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93035636
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93035636
10positive regulation by symbiont of host defense response (GO:0052509)4.89839478
11modulation by symbiont of host defense response (GO:0052031)4.89839478
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.89839478
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.89839478
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.89839478
15modulation by symbiont of host immune response (GO:0052553)4.89839478
16antigen processing and presentation of endogenous antigen (GO:0019883)4.71923348
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.69326707
18negative regulation of cell killing (GO:0031342)4.69326707
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.32156940
20response to peptidoglycan (GO:0032494)4.28113852
21interferon-gamma-mediated signaling pathway (GO:0060333)4.19913322
22positive regulation of gamma-delta T cell activation (GO:0046645)4.18940979
23T cell migration (GO:0072678)4.18204143
24negative regulation of viral genome replication (GO:0045071)4.15325977
25cellular response to interferon-alpha (GO:0035457)4.15108217
26cellular response to exogenous dsRNA (GO:0071360)4.14656413
27negative regulation of T cell mediated immunity (GO:0002710)4.10834757
28regulation of interferon-beta biosynthetic process (GO:0045357)4.09396610
29immunoglobulin mediated immune response (GO:0016064)4.07449171
30cellular response to interferon-beta (GO:0035458)4.05456442
31positive regulation of interferon-beta production (GO:0032728)4.03733746
32neutrophil activation involved in immune response (GO:0002283)3.93843161
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.91870803
34response to host immune response (GO:0052572)3.91870803
35response to interferon-beta (GO:0035456)3.90172992
36positive regulation of natural killer cell differentiation (GO:0032825)3.86854093
37negative regulation of interleukin-12 production (GO:0032695)3.76315780
38cellular response to virus (GO:0098586)3.71058576
39macrophage activation involved in immune response (GO:0002281)3.70623069
40regulation of type I interferon-mediated signaling pathway (GO:0060338)3.58985045
41detection of bacterium (GO:0016045)3.51714862
42detection of external biotic stimulus (GO:0098581)3.48925407
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.47242019
44positive regulation of type 2 immune response (GO:0002830)3.45382973
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.45312551
46response to host (GO:0075136)3.45312551
47response to host defenses (GO:0052200)3.45312551
48lymphocyte chemotaxis (GO:0048247)3.44615573
49NIK/NF-kappaB signaling (GO:0038061)3.43814185
50regulation of interleukin-12 biosynthetic process (GO:0045075)3.42932677
51negative regulation of lymphocyte mediated immunity (GO:0002707)3.42664036
52T-helper 1 type immune response (GO:0042088)3.42077829
53regulation of T-helper 1 cell differentiation (GO:0045625)3.36273309
54* regulation of RIG-I signaling pathway (GO:0039535)3.36120406
55positive regulation of toll-like receptor signaling pathway (GO:0034123)3.35642065
56* defense response to virus (GO:0051607)3.35433697
57cellular response to interferon-gamma (GO:0071346)3.34150554
58defense response to protozoan (GO:0042832)3.30580673
59cellular extravasation (GO:0045123)3.28376714
60respiratory burst (GO:0045730)3.27685935
61regulation of gamma-delta T cell differentiation (GO:0045586)3.26189457
62response to muramyl dipeptide (GO:0032495)3.24889340
63positive regulation of cAMP-mediated signaling (GO:0043950)3.24362730
64regulation of viral genome replication (GO:0045069)3.21260058
65regulation of type 2 immune response (GO:0002828)3.20876917
66positive regulation of defense response to virus by host (GO:0002230)3.16455082
67positive regulation of antigen processing and presentation (GO:0002579)3.16322640
68microglial cell activation (GO:0001774)3.15851337
69response to interleukin-15 (GO:0070672)3.15047314
70regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.12611579
71B cell mediated immunity (GO:0019724)3.12481298
72positive regulation of interleukin-12 production (GO:0032735)3.11612661
73myeloid cell activation involved in immune response (GO:0002275)3.09067441
74regulation of B cell receptor signaling pathway (GO:0050855)3.08713910
75regulation of necroptotic process (GO:0060544)3.07788454
76regulation of defense response to virus by host (GO:0050691)3.06859809
77regulation of T cell tolerance induction (GO:0002664)3.06249822
78neutrophil activation (GO:0042119)3.05702029
79negative regulation of leukocyte mediated immunity (GO:0002704)3.05579068
80regulation of T cell mediated cytotoxicity (GO:0001914)3.04923486
81negative regulation of cytokine production involved in immune response (GO:0002719)3.04511854
82regulation of regulatory T cell differentiation (GO:0045589)3.03318831
83negative regulation of viral process (GO:0048525)3.02964887
84natural killer cell mediated cytotoxicity (GO:0042267)3.01483031
85natural killer cell mediated immunity (GO:0002228)3.01483031
86regulation of interferon-beta production (GO:0032648)3.01325773
87antigen processing and presentation via MHC class Ib (GO:0002475)3.00441436
88detection of biotic stimulus (GO:0009595)3.00399122
89regulation of alpha-beta T cell proliferation (GO:0046640)2.99985294
90negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99663801
91detection of other organism (GO:0098543)2.99532664
92granulocyte activation (GO:0036230)2.98611976
93response to interferon-gamma (GO:0034341)2.98567697
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98214062
95leukocyte aggregation (GO:0070486)2.96701809
96positive regulation of chemokine biosynthetic process (GO:0045080)2.96316940
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.96192604
98response to protozoan (GO:0001562)2.95758935
99positive regulation of cellular amide metabolic process (GO:0034250)2.95678306
100positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.95481694
101cellular response to interleukin-15 (GO:0071350)2.95342162
102negative thymic T cell selection (GO:0045060)2.94799210
103positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94222043
104regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93759937
105regulation of natural killer cell mediated immunity (GO:0002715)2.93759937
106regulation of gamma-delta T cell activation (GO:0046643)2.93435740
107mature B cell differentiation (GO:0002335)2.92640361
108positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92628012
109negative T cell selection (GO:0043383)2.92218220
110regulation of natural killer cell differentiation (GO:0032823)2.91843607
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88807014
112positive regulation of T cell cytokine production (GO:0002726)2.88218060
113regulation of tolerance induction (GO:0002643)2.87823186
114regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87463602
115regulation of chemokine biosynthetic process (GO:0045073)2.86893527
116production of molecular mediator involved in inflammatory response (GO:0002532)2.85715377
117eosinophil chemotaxis (GO:0048245)2.85327347
118regulation of MHC class I biosynthetic process (GO:0045343)2.84266639
119positive regulation of interleukin-17 production (GO:0032740)2.84053806
120positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.82523238
121JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.81561185
122interferon-gamma secretion (GO:0072643)2.81457098
123detection of molecule of bacterial origin (GO:0032490)2.81399089
124regulation of activation of Janus kinase activity (GO:0010533)2.80188545
125regulation of response to interferon-gamma (GO:0060330)2.79336095
126regulation of antigen processing and presentation (GO:0002577)2.78670668
127monocyte chemotaxis (GO:0002548)2.78233517
128macrophage activation (GO:0042116)2.76307907
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75858590
130regulation of leukocyte mediated cytotoxicity (GO:0001910)2.74683354
131natural killer cell activation (GO:0030101)2.74676798
132negative regulation of type I interferon production (GO:0032480)2.74565481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.14469107
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.54608470
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.18584890
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.44904016
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.75543741
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.89697641
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.62649727
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58041445
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47907745
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30082604
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.24154881
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06383636
13GATA1_22025678_ChIP-Seq_K562_Human2.95156417
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.94108616
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68983589
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.68501443
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65861488
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.48042549
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46290494
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.07768691
21RUNX_20019798_ChIP-Seq_JUKART_Human1.88014232
22SPI1_23547873_ChIP-Seq_NB4_Human1.87699134
23MYB_26560356_Chip-Seq_TH2_Human1.87507723
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86812095
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86133728
26SCL_19346495_ChIP-Seq_HPC-7_Human1.85406403
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.73360203
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73205137
29MYB_26560356_Chip-Seq_TH1_Human1.63094114
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61839115
31PU_27001747_Chip-Seq_BMDM_Mouse1.61178765
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.61002773
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58938842
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57872862
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55335262
36* MAF_26560356_Chip-Seq_TH1_Human1.53645760
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42834034
38PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42741371
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.41507030
40SPI1_23127762_ChIP-Seq_K562_Human1.35609348
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34416462
42TP63_17297297_ChIP-ChIP_HaCaT_Human1.33136964
43CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30204198
44GATA3_26560356_Chip-Seq_TH2_Human1.29325914
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28605441
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27493845
47GATA3_27048872_Chip-Seq_THYMUS_Human1.26581716
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25382262
49VDR_24787735_ChIP-Seq_THP-1_Human1.23479440
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22589066
51VDR_24763502_ChIP-Seq_THP-1_Human1.22097228
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20401497
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20113227
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19971289
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15826037
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13770639
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09709357
58TCF7_22412390_ChIP-Seq_EML_Mouse1.04997036
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04628221
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03588892
61UTX_26944678_Chip-Seq_JUKART_Human0.96395336
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96081588
63SOX2_20726797_ChIP-Seq_SW620_Human0.94949245
64FOXO3_23340844_ChIP-Seq_DLD1_Human0.91312066
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90750316
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88772167
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88399670
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87195677
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86852564
70KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86623350
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85322294
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83060630
73EGR1_19032775_ChIP-ChIP_M12_Human0.81699368
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81679203
75LXR_22158963_ChIP-Seq_LIVER_Mouse0.80483198
76GATA1_19941827_ChIP-Seq_MEL_Mouse0.79935522
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79499834
78RXR_22158963_ChIP-Seq_LIVER_Mouse0.78813701
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78309453
80TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76583818
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75910087
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75594883
83PPARA_22158963_ChIP-Seq_LIVER_Mouse0.75187105
84* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74398553
85PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74248385
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74152488
87GATA2_19941826_ChIP-Seq_K562_Human0.74054852
88MAF_26560356_Chip-Seq_TH2_Human0.73982372
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73948058
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.73021600
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.72597635
92VDR_21846776_ChIP-Seq_THP-1_Human0.71952129
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71549468
94KDM2B_26808549_Chip-Seq_DND41_Human0.71159574
95MYC_22102868_ChIP-Seq_BL_Human0.70428237
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.69955253
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68530080
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68512475
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.68427116
100CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68264811
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67370576
102SMRT_27268052_Chip-Seq_Bcells_Human0.67105747
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.66311922
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.65947742
105* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64359368
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63868669
107PU.1_20513432_ChIP-Seq_Bcells_Mouse0.63513016
108GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63357042
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.63022009
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.60929826
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.60929826
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.60041813
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.60018476
114GATA1_19941826_ChIP-Seq_K562_Human0.59733076
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59347464
116PCGF2_27294783_Chip-Seq_ESCs_Mouse0.58764811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.67540940
2MP0009785_altered_susceptibility_to4.43567347
3MP0003724_increased_susceptibility_to3.71980917
4MP0005671_abnormal_response_to3.31361239
5MP0002148_abnormal_hypersensitivity_rea3.22388368
6MP0003436_decreased_susceptibility_to3.19708152
7MP0005025_abnormal_response_to3.15805813
8MP0001790_abnormal_immune_system3.09069564
9MP0005387_immune_system_phenotype3.09069564
10MP0000685_abnormal_immune_system3.01627492
11MP0005000_abnormal_immune_tolerance2.96156151
12MP0006082_CNS_inflammation2.90837370
13MP0002419_abnormal_innate_immunity2.86962243
14MP0001800_abnormal_humoral_immune2.68942964
15MP0002723_abnormal_immune_serum2.64925724
16MP0002452_abnormal_antigen_presenting2.64694767
17MP0001819_abnormal_immune_cell2.36238657
18MP0002420_abnormal_adaptive_immunity2.31917210
19MP0004510_myositis2.15327903
20MP0005058_abnormal_lysosome_morphology2.10291713
21MP0010155_abnormal_intestine_physiology2.07592290
22MP0005464_abnormal_platelet_physiology2.06078662
23MP0004947_skin_inflammation2.02684726
24MP0001853_heart_inflammation1.97207420
25MP0002166_altered_tumor_susceptibility1.96623842
26MP0009764_decreased_sensitivity_to1.95680829
27MP0002006_tumorigenesis1.94161234
28MP0003303_peritoneal_inflammation1.92962194
29MP0001533_abnormal_skeleton_physiology1.89636418
30MP0001845_abnormal_inflammatory_respons1.89475970
31MP0003191_abnormal_cellular_cholesterol1.87637631
32MP0003763_abnormal_thymus_physiology1.84284511
33MP0000716_abnormal_immune_system1.79003760
34MP0002405_respiratory_system_inflammati1.78526001
35MP0008469_abnormal_protein_level1.78095836
36MP0002398_abnormal_bone_marrow1.75696930
37MP0003448_altered_tumor_morphology1.57967887
38MP0009840_abnormal_foam_cell1.57840019
39MP0002254_reproductive_system_inflammat1.51389413
40MP0003300_gastrointestinal_ulcer1.50665766
41MP0009278_abnormal_bone_marrow1.50210245
42MP0009333_abnormal_splenocyte_physiolog1.48292624
43MP0005451_abnormal_body_composition1.47459012
44MP0000343_altered_response_to1.44381866
45MP0005167_abnormal_blood-brain_barrier1.43786629
46MP0002429_abnormal_blood_cell1.42693862
47MP0000689_abnormal_spleen_morphology1.41462399
48MP0000858_altered_metastatic_potential1.37147898
49MP0002722_abnormal_immune_system1.36247146
50MP0000569_abnormal_digit_pigmentation1.36105553
51MP0005310_abnormal_salivary_gland1.34429237
52MP0005397_hematopoietic_system_phenotyp1.32988740
53MP0001545_abnormal_hematopoietic_system1.32988740
54MP0005360_urolithiasis1.26423584
55MP0004883_abnormal_blood_vessel1.25981722
56MP0004381_abnormal_hair_follicle1.24876019
57MP0002138_abnormal_hepatobiliary_system1.23581233
58MP0003183_abnormal_peptide_metabolism1.23501576
59MP0003075_altered_response_to1.20584725
60MP0009763_increased_sensitivity_to1.20232927
61MP0002998_abnormal_bone_remodeling1.19361564
62MP0003045_fibrosis1.18539429
63MP0003866_abnormal_defecation1.13423987
64MP0004808_abnormal_hematopoietic_stem1.10189349
65MP0008004_abnormal_stomach_pH1.10111148
66MP0003172_abnormal_lysosome_physiology1.07282586
67MP0002332_abnormal_exercise_endurance1.00741682
68MP0005166_decreased_susceptibility_to0.99432116
69MP0002396_abnormal_hematopoietic_system0.96867612
70MP0003656_abnormal_erythrocyte_physiolo0.96333561
71MP0004782_abnormal_surfactant_physiolog0.95019378
72MP0003828_pulmonary_edema0.93442868
73MP0005174_abnormal_tail_pigmentation0.92957505
74MP0002877_abnormal_melanocyte_morpholog0.92547335
75MP0000604_amyloidosis0.91202001
76MP0003221_abnormal_cardiomyocyte_apopto0.89403242
77MP0002277_abnormal_respiratory_mucosa0.88500953
78MP0001663_abnormal_digestive_system0.87869322
79MP0000371_diluted_coat_color0.86100642
80MP0010352_gastrointestinal_tract_polyps0.86053336
81MP0001873_stomach_inflammation0.85835378
82MP0000703_abnormal_thymus_morphology0.85601320
83MP0003252_abnormal_bile_duct0.84629224
84MP0005390_skeleton_phenotype0.82972442
85MP0006054_spinal_hemorrhage0.80351490
86MP0000465_gastrointestinal_hemorrhage0.80034504
87MP0002132_abnormal_respiratory_system0.79961744
88MP0003453_abnormal_keratinocyte_physiol0.79415892
89MP0000249_abnormal_blood_vessel0.79209279
90MP0005164_abnormal_response_to0.78487724
91MP0002139_abnormal_hepatobiliary_system0.77029054
92MP0001851_eye_inflammation0.76316867
93MP0008874_decreased_physiological_sensi0.73391465
94MP0002933_joint_inflammation0.72615699
95MP0003806_abnormal_nucleotide_metabolis0.71722651
96MP0001958_emphysema0.71159463
97MP0009765_abnormal_xenobiotic_induced0.71133939
98MP0003091_abnormal_cell_migration0.70523481
99MP0003186_abnormal_redox_activity0.70335170
100MP0002796_impaired_skin_barrier0.68672560
101MP0002136_abnormal_kidney_physiology0.66694000
102MP0000015_abnormal_ear_pigmentation0.66580720
103MP0000609_abnormal_liver_physiology0.65993608
104MP0001666_abnormal_nutrient_absorption0.64450563
105MP0002009_preneoplasia0.62922408
106MP0004484_altered_response_of0.62521997
107MP0003690_abnormal_glial_cell0.61695254
108MP0005023_abnormal_wound_healing0.61213883
109MP0010307_abnormal_tumor_latency0.61002831
110MP0005075_abnormal_melanosome_morpholog0.59661699
111MP0000490_abnormal_crypts_of0.58622447
112MP0003795_abnormal_bone_structure0.57208986
113MP0001881_abnormal_mammary_gland0.55860421
114MP0001191_abnormal_skin_condition0.50182348
115MP0008260_abnormal_autophagy0.49300265
116MP0002019_abnormal_tumor_incidence0.49140047
117MP0005319_abnormal_enzyme/_coenzyme0.49080189
118MP0001764_abnormal_homeostasis0.47802647
119MP0009643_abnormal_urine_homeostasis0.47249947

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.92030494
2Recurrent abscess formation (HP:0002722)5.59138371
3Recurrent bacterial skin infections (HP:0005406)5.15483323
4Autoimmune thrombocytopenia (HP:0001973)5.03759988
5Elevated erythrocyte sedimentation rate (HP:0003565)4.64716772
6Recurrent fungal infections (HP:0002841)4.30075743
7Recurrent gram-negative bacterial infections (HP:0005420)4.29628810
8Increased IgM level (HP:0003496)4.13760448
9Recurrent viral infections (HP:0004429)4.08333493
10Mediastinal lymphadenopathy (HP:0100721)3.99878831
11Myositis (HP:0100614)3.97955286
12Abnormality of macrophages (HP:0004311)3.89211634
13Chronic otitis media (HP:0000389)3.85422821
14Recurrent skin infections (HP:0001581)3.81890495
15Chronic mucocutaneous candidiasis (HP:0002728)3.80900268
16Recurrent cutaneous fungal infections (HP:0011370)3.80900268
17Vacuolated lymphocytes (HP:0001922)3.72997333
18Vasculitis (HP:0002633)3.69042105
19Orchitis (HP:0100796)3.64893743
20Optic neuritis (HP:0100653)3.57531705
21Retrobulbar optic neuritis (HP:0100654)3.57531705
22Autoimmune hemolytic anemia (HP:0001890)3.53651655
23Gingivitis (HP:0000230)3.51834393
24Stomatitis (HP:0010280)3.43953450
25Basal ganglia calcification (HP:0002135)3.38325873
26Prostate neoplasm (HP:0100787)3.36132989
27Systemic lupus erythematosus (HP:0002725)3.25295863
28Hypergammaglobulinemia (HP:0010702)3.18444356
29Periodontitis (HP:0000704)3.15365107
30Chronic diarrhea (HP:0002028)3.05439886
31Pustule (HP:0200039)3.03861980
32Gingival bleeding (HP:0000225)2.94139439
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.92446539
34Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.92278129
35Leukocytosis (HP:0001974)2.92242466
36Pulmonary infiltrates (HP:0002113)2.91212713
37Recurrent bronchitis (HP:0002837)2.88446751
38Chronic obstructive pulmonary disease (HP:0006510)2.87808015
39Obstructive lung disease (HP:0006536)2.87808015
40Gastrointestinal infarctions (HP:0005244)2.86305989
41Abnormality of liposaccharide metabolism (HP:0010968)2.86248291
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.86248291
43Abnormality of glycolipid metabolism (HP:0010969)2.86248291
44Abnormality of T cell number (HP:0011839)2.84655803
45Axonal loss (HP:0003447)2.84502388
46Severe combined immunodeficiency (HP:0004430)2.81107591
47Eosinophilia (HP:0001880)2.80048763
48Abnormality of T cell physiology (HP:0011840)2.76482192
49Nasal polyposis (HP:0100582)2.74152267
50Hemoptysis (HP:0002105)2.73733584
51Colitis (HP:0002583)2.73670068
52Abnormality of T cells (HP:0002843)2.71639610
53Thyroiditis (HP:0100646)2.69462060
54Combined immunodeficiency (HP:0005387)2.67246497
55Abnormality of the nasal mucosa (HP:0000433)2.65130598
56Abnormality of eosinophils (HP:0001879)2.64744506
57Arterial thrombosis (HP:0004420)2.64543339
58Premature loss of primary teeth (HP:0006323)2.61620318
59Meningitis (HP:0001287)2.61031853
60Interstitial pulmonary disease (HP:0006530)2.59699267
61T lymphocytopenia (HP:0005403)2.56265312
62Inflammation of the large intestine (HP:0002037)2.55179034
63Peritonitis (HP:0002586)2.54006011
64Joint swelling (HP:0001386)2.49379393
65Granulocytopenia (HP:0001913)2.47392660
66Increased IgE level (HP:0003212)2.42572430
67Panhypogammaglobulinemia (HP:0003139)2.41800959
68Loss of speech (HP:0002371)2.41645651
69Cheilitis (HP:0100825)2.38500110
70Malnutrition (HP:0004395)2.38335970
71IgG deficiency (HP:0004315)2.37966547
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.37848425
73Cellulitis (HP:0100658)2.36968389
74Tetraparesis (HP:0002273)2.36749241
75Gangrene (HP:0100758)2.36105980
76Gastrointestinal inflammation (HP:0004386)2.35922227
77Petechiae (HP:0000967)2.33918952
78Spontaneous hematomas (HP:0007420)2.33510711
79Thick nail (HP:0001805)2.33296521
80Agammaglobulinemia (HP:0004432)2.32676197
81IgA deficiency (HP:0002720)2.32198728
82Epistaxis (HP:0000421)2.31240000
83Porencephaly (HP:0002132)2.30246198
84Abnormality of the prostate (HP:0008775)2.29386550
85Slow saccadic eye movements (HP:0000514)2.29250409
86Keratoconjunctivitis sicca (HP:0001097)2.28996808
87Joint hemorrhage (HP:0005261)2.27891203
88Osteomyelitis (HP:0002754)2.27246849
89Pulmonary embolism (HP:0002204)2.27235948
90Increased cerebral lipofuscin (HP:0011813)2.26932226
91Lymphopenia (HP:0001888)2.21214574
92Myocardial infarction (HP:0001658)2.21154758
93Abnormality of cells of the lymphoid lineage (HP:0012140)2.21008855
94Abnormality of the peritoneum (HP:0002585)2.19693652
95Prolonged bleeding time (HP:0003010)2.18340744
96Thrombocytosis (HP:0001894)2.18086007
97Urticaria (HP:0001025)2.17316773
98Anorexia (HP:0002039)2.17144603
99Encephalitis (HP:0002383)2.17080359
100Recurrent pneumonia (HP:0006532)2.12486019
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.11035306
102Osteolytic defects of the hand bones (HP:0009699)2.11035306
103Chronic sinusitis (HP:0011109)2.11018992
104Keratoconjunctivitis (HP:0001096)2.10508992
105IgM deficiency (HP:0002850)2.08770430
106Hematochezia (HP:0002573)2.08505214
107Recurrent lower respiratory tract infections (HP:0002783)2.07070082
108Abnormality of the pleura (HP:0002103)2.05866357
109Keratitis (HP:0000491)2.03672376
110Dysostosis multiplex (HP:0000943)2.01363099
111Glomerulopathy (HP:0100820)1.99705250
112Nephritis (HP:0000123)1.98868464
113Episodic fever (HP:0001954)1.98812776
114Chest pain (HP:0100749)1.98680535
115Skin ulcer (HP:0200042)1.96937988
116Progressive visual loss (HP:0000529)1.93273630
117Abnormality of B cell number (HP:0010975)1.91346381
118Abnormality of the endocardium (HP:0004306)1.91099920
119Amyloidosis (HP:0011034)1.86204748
120Increased CSF protein (HP:0002922)1.85729178
121Bronchitis (HP:0012387)1.84580804
122Viral hepatitis (HP:0006562)1.84015562
123Abnormality of the pericardium (HP:0001697)1.80813517
124Subacute progressive viral hepatitis (HP:0006572)1.78803947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IKBKE4.41999178
2MAP3K144.19359396
3TYK24.18682834
4TBK13.55523520
5JAK33.54576811
6TXK3.19247077
7FGFR42.93980367
8JAK12.86906050
9IRAK42.83925931
10KIT2.65426412
11BLK2.39578959
12MAP4K12.36340142
13IKBKB2.34574510
14PIK3CG2.30697808
15RIPK42.23586343
16MAP3K32.05730987
17MST41.94332856
18PRPF4B1.93841166
19IRAK31.92724139
20MAP3K131.89884956
21ZAP701.86954259
22TAOK21.82645375
23TAOK11.82092453
24FGFR31.79085923
25PBK1.75196226
26TAOK31.69923226
27CHUK1.52803702
28MAP3K111.49802714
29CSK1.48580106
30BTK1.45317007
31TEC1.45117795
32BMPR21.35598107
33EPHA31.34731280
34TGFBR21.30179989
35LCK1.30175474
36EPHB11.28066926
37RPS6KA41.26587343
38ERN11.23418141
39EIF2AK21.21833997
40SYK1.20364641
41HCK1.19772533
42NLK1.18892953
43JAK21.02801220
44LYN1.02625208
45PIM20.99121676
46CSF1R0.97858200
47NEK90.94492848
48IRAK10.94097022
49STK100.93185461
50ITK0.91673038
51TRPM70.88715315
52NUAK10.88181980
53TNK20.84316256
54PIM10.83400348
55MAP3K120.83113626
56MAPKAPK30.81204279
57MAP2K30.80625457
58MATK0.80133969
59BMPR1B0.76182417
60STK40.75914091
61CDC42BPA0.75186238
62CLK10.74828791
63FGR0.72291050
64MAP3K20.68873618
65KDR0.66876001
66MAPK110.64890616
67ADRBK20.63465289
68ACVR1B0.59923548
69MAP3K50.59739056
70FLT30.56808779
71FES0.56284868
72TGFBR10.55864316
73TIE10.55787731
74CAMKK20.54845177
75MAP3K60.51431042
76ERBB30.50570172
77PDGFRB0.50311159
78MAPK70.49611066
79RIPK10.49156825
80EGFR0.47859309
81PRKCQ0.47290416
82MST1R0.47148261
83GRK70.46683734
84PRKCD0.46398792
85SIK30.45983784
86IGF1R0.45508738
87MARK30.45040111
88FER0.44725510
89PTK2B0.41465578
90YES10.40726357
91ABL10.40279690
92STK30.40119118
93RPS6KA50.39821948
94STK240.38837902
95PDPK10.38330137
96DDR20.38290200
97PRKD20.37536732
98PTK60.37375192
99TNIK0.36943538
100MELK0.36873493
101CDK40.34925776
102BMX0.34646083
103FRK0.33400734
104SGK30.33310878
105MAP2K60.31676716
106PIK3CA0.30957113
107PRKG20.30220403
108LRRK20.30112814
109GRK60.29635783
110SGK20.27279085
111CDK60.26604856
112RET0.25488027
113FYN0.25401335
114MAPKAPK20.24042574
115HIPK20.23485265
116IRAK20.23000427
117INSR0.21039522
118GRK10.19946637
119MAP3K100.17627136
120MAPK30.14918366
121NME20.14422270
122PDK10.14044790
123MAP3K10.13806664
124MOS0.13721654
125MYLK0.13237831

Predicted pathways (KEGG)

RankGene SetZ-score
1RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.12217166
2Graft-versus-host disease_Homo sapiens_hsa053323.11986448
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.07895034
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.01400214
5Leishmaniasis_Homo sapiens_hsa051402.89714052
6Measles_Homo sapiens_hsa051622.86243580
7Allograft rejection_Homo sapiens_hsa053302.78230073
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.69308985
9Staphylococcus aureus infection_Homo sapiens_hsa051502.56095255
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.55273862
11Influenza A_Homo sapiens_hsa051642.39256365
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30467576
13Primary immunodeficiency_Homo sapiens_hsa053402.26752813
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20611264
15Legionellosis_Homo sapiens_hsa051342.16299032
16Herpes simplex infection_Homo sapiens_hsa051682.10620813
17Osteoclast differentiation_Homo sapiens_hsa043802.09006963
18Pertussis_Homo sapiens_hsa051331.95220697
19TNF signaling pathway_Homo sapiens_hsa046681.90188176
20Malaria_Homo sapiens_hsa051441.88261556
21Asthma_Homo sapiens_hsa053101.85155213
22Caffeine metabolism_Homo sapiens_hsa002321.72112733
23Antigen processing and presentation_Homo sapiens_hsa046121.66030382
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62530021
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.59869917
26Hematopoietic cell lineage_Homo sapiens_hsa046401.59673465
27Tuberculosis_Homo sapiens_hsa051521.59007964
28Toxoplasmosis_Homo sapiens_hsa051451.56392837
29African trypanosomiasis_Homo sapiens_hsa051431.55670137
30Hepatitis C_Homo sapiens_hsa051601.54125624
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51477025
32Autoimmune thyroid disease_Homo sapiens_hsa053201.50677550
33Type I diabetes mellitus_Homo sapiens_hsa049401.49640640
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48036098
35Rheumatoid arthritis_Homo sapiens_hsa053231.42895782
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41178803
37B cell receptor signaling pathway_Homo sapiens_hsa046621.38263834
38Salmonella infection_Homo sapiens_hsa051321.30555941
39Chemokine signaling pathway_Homo sapiens_hsa040621.30544482
40Hepatitis B_Homo sapiens_hsa051611.25944282
41Apoptosis_Homo sapiens_hsa042101.19915237
42Viral myocarditis_Homo sapiens_hsa054161.12441326
43T cell receptor signaling pathway_Homo sapiens_hsa046601.05202702
44Other glycan degradation_Homo sapiens_hsa005110.98817606
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98615819
46Lysosome_Homo sapiens_hsa041420.94601273
47Shigellosis_Homo sapiens_hsa051310.89403918
48Prolactin signaling pathway_Homo sapiens_hsa049170.86878746
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.85312662
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85221620
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80848391
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.80466542
53Phagosome_Homo sapiens_hsa041450.77335110
54Complement and coagulation cascades_Homo sapiens_hsa046100.73425341
55Acute myeloid leukemia_Homo sapiens_hsa052210.71429153
56Renal cell carcinoma_Homo sapiens_hsa052110.69905507
57Amoebiasis_Homo sapiens_hsa051460.68696717
58Dorso-ventral axis formation_Homo sapiens_hsa043200.67697343
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65692445
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65471901
61Non-small cell lung cancer_Homo sapiens_hsa052230.61463606
62Vitamin digestion and absorption_Homo sapiens_hsa049770.60965972
63ABC transporters_Homo sapiens_hsa020100.60037851
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59219253
65Renin-angiotensin system_Homo sapiens_hsa046140.58936321
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52846788
67Platelet activation_Homo sapiens_hsa046110.52488677
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50868428
69Small cell lung cancer_Homo sapiens_hsa052220.50319225
70Pancreatic cancer_Homo sapiens_hsa052120.49505874
71Mineral absorption_Homo sapiens_hsa049780.49494208
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.48715546
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47990432
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41262850
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39505830
76Epstein-Barr virus infection_Homo sapiens_hsa051690.38172489
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.37914835
78Galactose metabolism_Homo sapiens_hsa000520.36711343
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36327309
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36218326
81Endocytosis_Homo sapiens_hsa041440.36101110
82Chronic myeloid leukemia_Homo sapiens_hsa052200.35547941
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35449074
84Viral carcinogenesis_Homo sapiens_hsa052030.33401202
85Systemic lupus erythematosus_Homo sapiens_hsa053220.32731487
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32106593
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31897961
88Insulin resistance_Homo sapiens_hsa049310.31288863
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30496596
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30419774
91Endometrial cancer_Homo sapiens_hsa052130.29252311
92Thyroid cancer_Homo sapiens_hsa052160.28325907
93Starch and sucrose metabolism_Homo sapiens_hsa005000.27684482
94Type II diabetes mellitus_Homo sapiens_hsa049300.27052452
95Prostate cancer_Homo sapiens_hsa052150.26833004
96GnRH signaling pathway_Homo sapiens_hsa049120.26336065
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.25879140
98Fat digestion and absorption_Homo sapiens_hsa049750.25222134
99MAPK signaling pathway_Homo sapiens_hsa040100.24801786
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24651932
101HIF-1 signaling pathway_Homo sapiens_hsa040660.24592470
102p53 signaling pathway_Homo sapiens_hsa041150.24406729
103FoxO signaling pathway_Homo sapiens_hsa040680.24099410
104Histidine metabolism_Homo sapiens_hsa003400.23745511
105mTOR signaling pathway_Homo sapiens_hsa041500.22133043
106Arachidonic acid metabolism_Homo sapiens_hsa005900.21987535
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21522864
108Prion diseases_Homo sapiens_hsa050200.20526751
109Notch signaling pathway_Homo sapiens_hsa043300.20462880
110Choline metabolism in cancer_Homo sapiens_hsa052310.20040866
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19399559
112HTLV-I infection_Homo sapiens_hsa051660.19343223
113Sphingolipid metabolism_Homo sapiens_hsa006000.16197697
114Folate biosynthesis_Homo sapiens_hsa007900.15306773
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.14365132
116Inositol phosphate metabolism_Homo sapiens_hsa005620.13259747
117Peroxisome_Homo sapiens_hsa041460.10456984
118VEGF signaling pathway_Homo sapiens_hsa043700.10313379

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