DDX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.16579068
2regulation of NFAT protein import into nucleus (GO:0051532)3.94913108
3positive regulation of histone deacetylation (GO:0031065)3.91050125
4nucleus localization (GO:0051647)3.70460774
5* cytoplasmic mRNA processing body assembly (GO:0033962)3.66368106
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.64617421
7negative regulation of cell killing (GO:0031342)3.64617421
8negative regulation of DNA repair (GO:0045738)3.46121102
9insulin-like growth factor receptor signaling pathway (GO:0048009)3.35561403
10monoubiquitinated protein deubiquitination (GO:0035520)3.28279832
11activated T cell proliferation (GO:0050798)3.26474720
12pre-miRNA processing (GO:0031054)3.25299793
13mitotic sister chromatid cohesion (GO:0007064)3.15406094
14neural tube formation (GO:0001841)3.13179747
15protein localization to endosome (GO:0036010)3.10782854
16glucocorticoid receptor signaling pathway (GO:0042921)3.10453503
17neuronal stem cell maintenance (GO:0097150)3.05237536
18central nervous system projection neuron axonogenesis (GO:0021952)3.03426555
19interkinetic nuclear migration (GO:0022027)3.02768958
20regulation of RNA export from nucleus (GO:0046831)2.99787508
21positive regulation of gamma-delta T cell activation (GO:0046645)2.99759214
22regulation of gamma-delta T cell differentiation (GO:0045586)2.99249593
23growth hormone receptor signaling pathway (GO:0060396)2.97444653
24histone H3-K36 demethylation (GO:0070544)2.96669364
25cytoskeletal anchoring at plasma membrane (GO:0007016)2.94629339
26regulation of pigment cell differentiation (GO:0050932)2.94325070
27histone H3-K9 demethylation (GO:0033169)2.90335443
28positive thymic T cell selection (GO:0045059)2.90238185
29corticosteroid receptor signaling pathway (GO:0031958)2.83007536
30germ cell migration (GO:0008354)2.82280773
31peptidyl-lysine dimethylation (GO:0018027)2.77696754
32regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.77626202
33NLS-bearing protein import into nucleus (GO:0006607)2.76465185
34negative regulation of neurotransmitter secretion (GO:0046929)2.72729318
35negative regulation of histone methylation (GO:0031061)2.70774207
36peptidyl-lysine trimethylation (GO:0018023)2.69758165
37regulation of gamma-delta T cell activation (GO:0046643)2.69402242
38RNA stabilization (GO:0043489)2.67477763
39mRNA stabilization (GO:0048255)2.67477763
40hippo signaling (GO:0035329)2.67117957
41regulation of nucleobase-containing compound transport (GO:0032239)2.64856321
42positive regulation by host of viral transcription (GO:0043923)2.64843379
43negative regulation of fatty acid transport (GO:2000192)2.63435791
44positive T cell selection (GO:0043368)2.61637132
45nuclear pore complex assembly (GO:0051292)2.60800299
46thymic T cell selection (GO:0045061)2.60529868
47lipid translocation (GO:0034204)2.58470929
48phospholipid translocation (GO:0045332)2.58470929
49glial cell proliferation (GO:0014009)2.57359030
50cerebellar Purkinje cell differentiation (GO:0021702)2.56991234
51antigen processing and presentation of endogenous antigen (GO:0019883)2.55077873
52presynaptic membrane assembly (GO:0097105)2.54500193
53pyrimidine nucleobase catabolic process (GO:0006208)2.53938934
54cellular response to growth hormone stimulus (GO:0071378)2.53837196
55radial glial cell differentiation (GO:0060019)2.53414593
56dorsal/ventral axis specification (GO:0009950)2.53123591
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48472876
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48472876
59protein K48-linked deubiquitination (GO:0071108)2.47922273
60embryonic eye morphogenesis (GO:0048048)2.47824370
61histone lysine demethylation (GO:0070076)2.47813548
62histone H3-K4 methylation (GO:0051568)2.47767202
63centrosome localization (GO:0051642)2.47323099
64protein dealkylation (GO:0008214)2.46954913
65protein demethylation (GO:0006482)2.46954913
66negative T cell selection (GO:0043383)2.46415342
67epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.46051028
68central nervous system neuron axonogenesis (GO:0021955)2.45887226
69negative thymic T cell selection (GO:0045060)2.44023838
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.43657062
71pore complex assembly (GO:0046931)2.43085483
72T cell selection (GO:0045058)2.42971118
73cortical actin cytoskeleton organization (GO:0030866)2.42946880
74negative regulation of inclusion body assembly (GO:0090084)2.41765532
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41698883
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.41698883
77regulation of translation, ncRNA-mediated (GO:0045974)2.41698883
78embryonic retina morphogenesis in camera-type eye (GO:0060059)2.39326621
79histone H4-K16 acetylation (GO:0043984)2.37726598
80positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.37272848
81embryonic process involved in female pregnancy (GO:0060136)2.37207938
82embryonic hemopoiesis (GO:0035162)2.36342979
83positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.35348457
84regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.35348457
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33883221
86regulation of histone deacetylation (GO:0031063)2.33757931
87positive regulation of developmental pigmentation (GO:0048087)2.33124565
88gastrulation with mouth forming second (GO:0001702)2.33031725
89regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.32868215
90positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.32868215
91stress granule assembly (GO:0034063)2.32773207
92positive regulation of mRNA 3-end processing (GO:0031442)2.32500292
93positive regulation of mRNA processing (GO:0050685)2.32106317
94positive regulation of RNA splicing (GO:0033120)2.30554786
95peptidyl-threonine modification (GO:0018210)2.30415386
96adherens junction assembly (GO:0034333)2.29986219
97negative regulation of neurotransmitter transport (GO:0051589)2.29000088
98heart valve formation (GO:0003188)2.28951936
99positive regulation of glycogen biosynthetic process (GO:0045725)2.28913544
100regulation of glial cell proliferation (GO:0060251)2.28617809
101negative regulation of glial cell proliferation (GO:0060253)2.28363945
102dopaminergic neuron differentiation (GO:0071542)2.28303253
103histone-serine phosphorylation (GO:0035404)2.27938850
104positive regulation of hormone biosynthetic process (GO:0046886)2.27253393
105protein localization to microtubule cytoskeleton (GO:0072698)2.26632236
106positive regulation of protein deacetylation (GO:0090312)2.25753820
107peptidyl-threonine phosphorylation (GO:0018107)2.25270721
108dendrite morphogenesis (GO:0048813)2.25098349
109limb bud formation (GO:0060174)2.25068421
110neuron recognition (GO:0008038)2.24962293
111morphogenesis of an epithelial sheet (GO:0002011)2.24914623
112nerve growth factor signaling pathway (GO:0038180)2.24593170
113regulation of cAMP-dependent protein kinase activity (GO:2000479)2.24424103
114regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24036325
115protein localization to microtubule (GO:0035372)2.23842206
116negative regulation of smooth muscle cell differentiation (GO:0051151)2.23275705
117retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22115876
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22064627
119histone demethylation (GO:0016577)2.22024691
120peptidyl-lysine methylation (GO:0018022)2.21787233
121presynaptic membrane organization (GO:0097090)2.21742685
122regulation of mRNA catabolic process (GO:0061013)2.19898183
123regulation of mRNA stability (GO:0043488)2.19506908
124peptidyl-serine phosphorylation (GO:0018105)2.17967950
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.17761881
126alternative mRNA splicing, via spliceosome (GO:0000380)2.17470147
127peptidyl-threonine dephosphorylation (GO:0035970)2.17178133
128regulation of establishment of cell polarity (GO:2000114)2.16645549
129platelet-derived growth factor receptor signaling pathway (GO:0048008)2.15072245
130protein K11-linked deubiquitination (GO:0035871)2.15059736
131establishment of nucleus localization (GO:0040023)2.14656865
132axonal fasciculation (GO:0007413)2.14401914
133histone lysine methylation (GO:0034968)2.14275442
134positive regulation of mRNA catabolic process (GO:0061014)2.14230391
135histone H3-K4 trimethylation (GO:0080182)2.13744504
136cellular response to ethanol (GO:0071361)2.13115174
137nuclear pore organization (GO:0006999)2.12878941
138embryonic foregut morphogenesis (GO:0048617)2.12355900
139cell differentiation in hindbrain (GO:0021533)2.12063939
140negative regulation of NF-kappaB import into nucleus (GO:0042347)2.11884693
141coronary vasculature morphogenesis (GO:0060977)2.11777018
142embryonic camera-type eye morphogenesis (GO:0048596)2.10625393
143receptor catabolic process (GO:0032801)2.10453071
144negative regulation of cardiac muscle tissue growth (GO:0055022)2.09614927
145negative regulation of heart growth (GO:0061117)2.09614927
146protein targeting to Golgi (GO:0000042)2.09163014
147layer formation in cerebral cortex (GO:0021819)2.08581008
148cell migration involved in sprouting angiogenesis (GO:0002042)2.08453355
149regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.07834345
150regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.04655416
151COPI coating of Golgi vesicle (GO:0048205)2.04086575
152Golgi transport vesicle coating (GO:0048200)2.04086575
153planar cell polarity pathway involved in neural tube closure (GO:0090179)2.03684212
154positive regulation of Rap GTPase activity (GO:0032854)2.03538666
155regulation of polysaccharide biosynthetic process (GO:0032885)2.03458048
156activation of JUN kinase activity (GO:0007257)2.02860724
157regulation of protein polyubiquitination (GO:1902914)2.02356967
158regulation of RNA stability (GO:0043487)2.00334731
159regulation of ARF GTPase activity (GO:0032312)2.00262382
160establishment of protein localization to Golgi (GO:0072600)1.99100594
161regulation of protein deacetylation (GO:0090311)1.98516955
162response to laminar fluid shear stress (GO:0034616)1.98021612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.21149693
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88820369
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.80503583
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.61934252
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23269323
6MYC_22102868_ChIP-Seq_BL_Human2.65067036
7EZH2_22144423_ChIP-Seq_EOC_Human2.42871464
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.20234311
9* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.19620838
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17880313
11KDM2B_26808549_Chip-Seq_DND41_Human2.16484434
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14673091
13GBX2_23144817_ChIP-Seq_PC3_Human2.10716217
14CLOCK_20551151_ChIP-Seq_293T_Human2.08505654
15AR_21572438_ChIP-Seq_LNCaP_Human2.05363058
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04241441
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.02684333
18TAF15_26573619_Chip-Seq_HEK293_Human2.01329261
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98058778
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96320477
21* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90968661
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89350452
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88667418
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.86944860
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.84298874
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.83646925
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.82435206
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82057205
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82005878
30RUNX_20019798_ChIP-Seq_JUKART_Human1.81209745
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81154668
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81039507
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80618490
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79695549
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.79569519
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79143014
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.75399228
38FUS_26573619_Chip-Seq_HEK293_Human1.74110820
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70726436
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66622056
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.66407777
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66371110
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62794059
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58461521
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.57954387
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57000291
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.56183823
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53369428
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52991458
50KDM2B_26808549_Chip-Seq_K562_Human1.51866260
51GATA1_22025678_ChIP-Seq_K562_Human1.49594686
52SMAD4_21799915_ChIP-Seq_A2780_Human1.48729573
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46996564
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45389936
55EWS_26573619_Chip-Seq_HEK293_Human1.44956346
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43479693
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.43394603
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42948120
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42948120
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41845199
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.41614466
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40629202
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.40523780
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40418526
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39767593
66VDR_21846776_ChIP-Seq_THP-1_Human1.39362760
67* MAF_26560356_Chip-Seq_TH1_Human1.38075420
68STAT3_23295773_ChIP-Seq_U87_Human1.37018421
69P300_19829295_ChIP-Seq_ESCs_Human1.36856564
70UTX_26944678_Chip-Seq_JUKART_Human1.35097182
71* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34509667
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34310405
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32693059
74STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32183338
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.32131918
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30447293
77MYB_26560356_Chip-Seq_TH2_Human1.30366998
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.29491167
79* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28811501
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28262714
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27696065
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27569716
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26114029
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.25414432
85* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24790284
86* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23984865
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.23870126
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23444448
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.23318885
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.23104093
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.23090838
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.22958147
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22531255
94TP53_16413492_ChIP-PET_HCT116_Human1.22354744
95AHR_22903824_ChIP-Seq_MCF-7_Human1.22111751
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20855433
97ER_23166858_ChIP-Seq_MCF-7_Human1.20724492
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20350893
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20092567
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17265663
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17006887
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.15347693
103* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14650165
104* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14415595
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13162111
106ZNF263_19887448_ChIP-Seq_K562_Human1.12604209
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12542640
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11556288
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11180052
110VDR_24763502_ChIP-Seq_THP-1_Human1.11159468
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10900550
112FLI1_27457419_Chip-Seq_LIVER_Mouse1.10392313
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.10256130
114TCF4_23295773_ChIP-Seq_U87_Human1.10235147
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.09576274
116JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09121009
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09026352
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08664158
119* MYB_26560356_Chip-Seq_TH1_Human1.08459675
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08381576
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.08108863
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07443744
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07443744
124RNF2_27304074_Chip-Seq_ESCs_Mouse1.07297982
125* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07082279
126GATA1_19941826_ChIP-Seq_K562_Human1.06053242
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05866110
128IGF1R_20145208_ChIP-Seq_DFB_Human1.05665342
129BRD4_25478319_ChIP-Seq_HGPS_Human1.05099699
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.04613739
131FOXA2_19822575_ChIP-Seq_HepG2_Human1.03869836
132NCOR1_26117541_ChIP-Seq_K562_Human1.03297898
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02920193
134CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02516078
135TBX20_22328084_ChIP-Seq_HEART_Mouse1.02427638
136TBX20_22080862_ChIP-Seq_HEART_Mouse1.02427638
137EP300_21415370_ChIP-Seq_HL-1_Mouse1.02326666
138KDM2B_26808549_Chip-Seq_REH_Human1.01714385
139TCF4_18268006_ChIP-ChIP_LS174T_Human1.01556397
140FLI1_21867929_ChIP-Seq_TH2_Mouse1.01039282
141IRF8_27001747_Chip-Seq_BMDM_Mouse1.00763264
142E2F7_22180533_ChIP-Seq_HELA_Human1.00714790
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.00625911
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00141105
145BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00048173
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99500859
147SPI1_23127762_ChIP-Seq_K562_Human0.99442597
148RXR_22108803_ChIP-Seq_LS180_Human0.99032192
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98391458
150SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98391458
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98360190
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98108649
153SOX9_26525672_Chip-Seq_HEART_Mouse0.98078298
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97569243
155TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97506578
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96143513
157CHD1_26751641_Chip-Seq_LNCaP_Human0.96041884
158SCL_19346495_ChIP-Seq_HPC-7_Human0.94105947
159VDR_24787735_ChIP-Seq_THP-1_Human0.94020992
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93661692
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.93404000
162RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93289237
163ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91988470
164CREB1_26743006_Chip-Seq_LNCaP_Human0.91879030
165GATA6_25053715_ChIP-Seq_YYC3_Human0.91104301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.51036883
2MP0010234_abnormal_vibrissa_follicle4.05606132
3MP0003300_gastrointestinal_ulcer3.92136911
4MP0000569_abnormal_digit_pigmentation3.49634039
5MP0005076_abnormal_cell_differentiation3.48114477
6MP0003705_abnormal_hypodermis_morpholog3.27060206
7MP0010352_gastrointestinal_tract_polyps3.04961519
8MP0002877_abnormal_melanocyte_morpholog2.76856524
9MP0003303_peritoneal_inflammation2.68563045
10MP0000778_abnormal_nervous_system2.45351925
11MP0000537_abnormal_urethra_morphology2.21410296
12MP0005409_darkened_coat_color2.13827085
13MP0002166_altered_tumor_susceptibility2.00199973
14MP0004185_abnormal_adipocyte_glucose1.98647039
15MP0008961_abnormal_basal_metabolism1.91465091
16MP0000733_abnormal_muscle_development1.86451320
17MP0003566_abnormal_cell_adhesion1.83223317
18MP0010678_abnormal_skin_adnexa1.81577629
19MP0001849_ear_inflammation1.77996169
20MP0009278_abnormal_bone_marrow1.76876800
21MP0006054_spinal_hemorrhage1.72024334
22MP0003045_fibrosis1.70522800
23MP0009053_abnormal_anal_canal1.66200918
24MP0000566_synostosis1.63316432
25MP0003221_abnormal_cardiomyocyte_apopto1.61315837
26MP0002009_preneoplasia1.60586126
27MP0003091_abnormal_cell_migration1.59488204
28MP0009780_abnormal_chondrocyte_physiolo1.56264968
29MP0001286_abnormal_eye_development1.56229123
30MP0005623_abnormal_meninges_morphology1.54850337
31MP0002396_abnormal_hematopoietic_system1.52828404
32MP0003787_abnormal_imprinting1.46681041
33MP0000428_abnormal_craniofacial_morphol1.45394310
34MP0003937_abnormal_limbs/digits/tail_de1.40752650
35MP0008438_abnormal_cutaneous_collagen1.36929766
36MP0005187_abnormal_penis_morphology1.36180564
37MP0004808_abnormal_hematopoietic_stem1.35778038
38MP0004197_abnormal_fetal_growth/weight/1.35519814
39MP0002006_tumorigenesis1.33360609
40MP0004947_skin_inflammation1.32969675
41MP0001177_atelectasis1.32538130
42MP0004381_abnormal_hair_follicle1.32435638
43MP0010307_abnormal_tumor_latency1.22287212
44MP0000955_abnormal_spinal_cord1.21550499
45MP0003861_abnormal_nervous_system1.20761297
46MP0005275_abnormal_skin_tensile1.20456152
47MP0002896_abnormal_bone_mineralization1.19710531
48MP0009703_decreased_birth_body1.18704491
49MP0002925_abnormal_cardiovascular_devel1.18238258
50MP0005375_adipose_tissue_phenotype1.17709444
51MP0003632_abnormal_nervous_system1.17562404
52MP0005666_abnormal_adipose_tissue1.15703669
53MP0004264_abnormal_extraembryonic_tissu1.15047805
54MP0005387_immune_system_phenotype1.14729665
55MP0001790_abnormal_immune_system1.14729665
56MP0003935_abnormal_craniofacial_develop1.14236457
57MP0000383_abnormal_hair_follicle1.14030821
58MP0000003_abnormal_adipose_tissue1.13044636
59MP0003763_abnormal_thymus_physiology1.12324282
60MP0001800_abnormal_humoral_immune1.09006559
61MP0004883_abnormal_blood_vessel1.08650667
62MP0004272_abnormal_basement_membrane1.08636984
63MP0003121_genomic_imprinting1.07991229
64MP0001299_abnormal_eye_distance/1.07973979
65MP0001440_abnormal_grooming_behavior1.07816724
66MP0004742_abnormal_vestibular_system1.06427059
67MP0002928_abnormal_bile_duct1.05570623
68MP0003453_abnormal_keratinocyte_physiol1.05364732
69MP0002081_perinatal_lethality1.05019539
70MP0002086_abnormal_extraembryonic_tissu1.04352021
71MP0002254_reproductive_system_inflammat1.03555186
72MP0001851_eye_inflammation1.02986247
73MP0000685_abnormal_immune_system1.02584208
74MP0001348_abnormal_lacrimal_gland1.02259106
75MP0005248_abnormal_Harderian_gland1.01774274
76MP0002152_abnormal_brain_morphology1.01199266
77MP0002084_abnormal_developmental_patter1.00621962
78MP0002184_abnormal_innervation1.00341668
79MP0000703_abnormal_thymus_morphology1.00029877
80MP0000534_abnormal_ureter_morphology0.99497588
81MP0001293_anophthalmia0.98854199
82MP0003635_abnormal_synaptic_transmissio0.98801853
83MP0003115_abnormal_respiratory_system0.98133676
84MP0002063_abnormal_learning/memory/cond0.96156817
85MP0001915_intracranial_hemorrhage0.95393416
86MP0005174_abnormal_tail_pigmentation0.95183346
87MP0002092_abnormal_eye_morphology0.94991980
88MP0010630_abnormal_cardiac_muscle0.93857967
89MP0005367_renal/urinary_system_phenotyp0.92268466
90MP0000516_abnormal_urinary_system0.92268466
91MP0009384_cardiac_valve_regurgitation0.92218508
92MP0002088_abnormal_embryonic_growth/wei0.92145232
93MP0001879_abnormal_lymphatic_vessel0.91458969
94MP0003122_maternal_imprinting0.90997839
95MP0005023_abnormal_wound_healing0.89312507
96MP0003984_embryonic_growth_retardation0.89174694
97MP0002822_catalepsy0.89044869
98MP0003385_abnormal_body_wall0.88291093
99MP0002697_abnormal_eye_size0.88217933
100MP0002909_abnormal_adrenal_gland0.87744648
101MP0000767_abnormal_smooth_muscle0.87646957
102MP0003283_abnormal_digestive_organ0.87579668
103MP0001784_abnormal_fluid_regulation0.87428362
104MP0001958_emphysema0.86886979
105MP0009672_abnormal_birth_weight0.86544126
106MP0005423_abnormal_somatic_nervous0.86242724
107MP0003828_pulmonary_edema0.86035363
108MP0002133_abnormal_respiratory_system0.86021582
109MP0005388_respiratory_system_phenotype0.86021582
110MP0000427_abnormal_hair_cycle0.84750671
111MP0003890_abnormal_embryonic-extraembry0.84262911
112MP0000377_abnormal_hair_follicle0.84094733
113MP0002398_abnormal_bone_marrow0.83789270
114MP0004134_abnormal_chest_morphology0.82997885
115MP0000432_abnormal_head_morphology0.82918273
116MP0000631_abnormal_neuroendocrine_gland0.82854783
117MP0010155_abnormal_intestine_physiology0.82271076
118MP0002067_abnormal_sensory_capabilities0.81418021
119MP0004924_abnormal_behavior0.80771527
120MP0005386_behavior/neurological_phenoty0.80771527
121MP0004811_abnormal_neuron_physiology0.79797698
122MP0004510_myositis0.79590765
123MP0003755_abnormal_palate_morphology0.79356195
124MP0002452_abnormal_antigen_presenting0.79286738
125MP0003567_abnormal_fetal_cardiomyocyte0.78141092
126MP0001672_abnormal_embryogenesis/_devel0.77395352
127MP0005380_embryogenesis_phenotype0.77395352
128MP0001873_stomach_inflammation0.76260287
129MP0003448_altered_tumor_morphology0.75622621
130MP0003136_yellow_coat_color0.74769783
131MP0000350_abnormal_cell_proliferation0.74302207
132MP0004130_abnormal_muscle_cell0.74263434
133MP0001943_abnormal_respiration0.73255158
134MP0003123_paternal_imprinting0.73160127
135MP0003880_abnormal_central_pattern0.73121512
136MP0001188_hyperpigmentation0.73099252
137MP0003119_abnormal_digestive_system0.72839313
138MP0004885_abnormal_endolymph0.72689948
139MP0002234_abnormal_pharynx_morphology0.72648931
140MP0002168_other_aberrant_phenotype0.72636938
141MP0004270_analgesia0.72038653
142MP0003868_abnormal_feces_composition0.71479882
143MP0003942_abnormal_urinary_system0.71429594
144MP0003690_abnormal_glial_cell0.71165425
145MP0002128_abnormal_blood_circulation0.70814866
146MP0000266_abnormal_heart_morphology0.70465331
147MP0008569_lethality_at_weaning0.70189217
148MP0002085_abnormal_embryonic_tissue0.69316706
149MP0002882_abnormal_neuron_morphology0.69253390
150MP0004142_abnormal_muscle_tone0.68871018
151MP0002751_abnormal_autonomic_nervous0.68691645
152MP0002998_abnormal_bone_remodeling0.68480083
153MP0002420_abnormal_adaptive_immunity0.68277567
154MP0003938_abnormal_ear_development0.66935822

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.63443480
2Macroorchidism (HP:0000053)3.63397466
3Cerebral aneurysm (HP:0004944)2.89651096
4Abnormality of the fingertips (HP:0001211)2.86430048
5Subacute progressive viral hepatitis (HP:0006572)2.82539181
6Hematochezia (HP:0002573)2.80326820
7Hyperacusis (HP:0010780)2.78561336
8Neonatal hypoglycemia (HP:0001998)2.73482691
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66388733
10Short 4th metacarpal (HP:0010044)2.66388733
11Shallow orbits (HP:0000586)2.58197195
12Pheochromocytoma (HP:0002666)2.46142162
13Protruding tongue (HP:0010808)2.43068766
14Asymmetry of the thorax (HP:0001555)2.42483160
15Aortic aneurysm (HP:0004942)2.41294420
16Genetic anticipation (HP:0003743)2.40401610
17Hyperventilation (HP:0002883)2.40313518
18Curly hair (HP:0002212)2.40150603
19Thyroid carcinoma (HP:0002890)2.38116659
20Acute myeloid leukemia (HP:0004808)2.35327293
21Mitral valve prolapse (HP:0001634)2.35283592
22Drooling (HP:0002307)2.34716169
23Volvulus (HP:0002580)2.34391885
24Overgrowth (HP:0001548)2.33276249
25Narrow palate (HP:0000189)2.31006756
26Excessive salivation (HP:0003781)2.30760818
27Increased density of long bones (HP:0006392)2.29219762
28Large earlobe (HP:0009748)2.26614524
29Abnormality of the 4th metacarpal (HP:0010012)2.24611574
30Hepatoblastoma (HP:0002884)2.20026065
31Ankyloglossia (HP:0010296)2.13370731
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12451472
33Heterotopia (HP:0002282)2.12302588
34Elfin facies (HP:0004428)2.11868455
35Persistence of primary teeth (HP:0006335)2.11550966
36Abnormality of oral frenula (HP:0000190)2.08769429
37Rectal prolapse (HP:0002035)2.04626871
38Enlarged penis (HP:0000040)2.04193932
39Missing ribs (HP:0000921)2.03916974
40Ulnar bowing (HP:0003031)2.03604632
41T lymphocytopenia (HP:0005403)2.01539525
42Absent frontal sinuses (HP:0002688)2.01281712
43Vertebral arch anomaly (HP:0008438)1.99809083
44Disproportionate tall stature (HP:0001519)1.99418771
45Dilatation of the ascending aorta (HP:0005111)1.98559474
46Hamartoma (HP:0010566)1.98447544
47Cystic hygroma (HP:0000476)1.98316854
48Renovascular hypertension (HP:0100817)1.97345516
49Renal duplication (HP:0000075)1.96552974
50Aneurysm (HP:0002617)1.95252066
51Midline defect of the nose (HP:0004122)1.93063893
52Abnormality of the left ventricular outflow tract (HP:0011103)1.92608329
53Subaortic stenosis (HP:0001682)1.92608329
54Bowel diverticulosis (HP:0005222)1.92538143
55Hypoplasia of the maxilla (HP:0000327)1.92335769
56Abnormality of the ischium (HP:0003174)1.92068937
57Abnormal hair whorl (HP:0010721)1.91170754
58Abnormality of the parietal bone (HP:0002696)1.91057586
59Pseudobulbar signs (HP:0002200)1.91019551
60Sporadic (HP:0003745)1.89008176
61Progressive cerebellar ataxia (HP:0002073)1.88845143
62Transitional cell carcinoma of the bladder (HP:0006740)1.88814544
63Abnormality of T cell number (HP:0011839)1.88669707
64Bicuspid aortic valve (HP:0001647)1.88111570
6511 pairs of ribs (HP:0000878)1.87263064
66Tapered finger (HP:0001182)1.86064201
67Sandal gap (HP:0001852)1.85429645
68Dysmetric saccades (HP:0000641)1.83385424
69Lymphangioma (HP:0100764)1.83356553
70Overriding aorta (HP:0002623)1.83154789
71Insidious onset (HP:0003587)1.81860815
72Termporal pattern (HP:0011008)1.81860815
73Abnormality of the nasal septum (HP:0000419)1.81693650
74Depressed nasal tip (HP:0000437)1.80547684
75Abnormality of chromosome segregation (HP:0002916)1.80251459
76Febrile seizures (HP:0002373)1.80099830
77Hallux valgus (HP:0001822)1.79997061
78Obsessive-compulsive behavior (HP:0000722)1.79335812
79Deviation of the hallux (HP:0010051)1.78208875
80Abnormality of the corticospinal tract (HP:0002492)1.77769104
81Pelvic girdle muscle weakness (HP:0003749)1.77554029
82Viral hepatitis (HP:0006562)1.76501713
83Long eyelashes (HP:0000527)1.76402508
84Malignant gastrointestinal tract tumors (HP:0006749)1.76030041
85Gastrointestinal carcinoma (HP:0002672)1.76030041
86Exostoses (HP:0100777)1.75506931
87Fair hair (HP:0002286)1.73666312
88Exotropia (HP:0000577)1.73422300
89Bladder carcinoma (HP:0002862)1.73413703
90Bladder neoplasm (HP:0009725)1.73413703
91Buphthalmos (HP:0000557)1.73311201
92Arterial tortuosity (HP:0005116)1.72686448
93Broad thumb (HP:0011304)1.72452125
94Papilledema (HP:0001085)1.72014378
95Increased nuchal translucency (HP:0010880)1.71251739
96Neuroendocrine neoplasm (HP:0100634)1.70883656
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.70192986
98Spinal cord lesions (HP:0100561)1.69965233
99Syringomyelia (HP:0003396)1.69965233
100Megalencephaly (HP:0001355)1.68673109
101Abnormality of salivation (HP:0100755)1.68665817
102Thin bony cortex (HP:0002753)1.68423814
103Bladder diverticulum (HP:0000015)1.66878110
104Scapular winging (HP:0003691)1.66683427
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.66288330
106Osteolytic defects of the hand bones (HP:0009699)1.66288330
107Thick eyebrow (HP:0000574)1.66042150
108Abnormality of the gastric mucosa (HP:0004295)1.65494174
109Tracheomalacia (HP:0002779)1.65454431
110Cubitus valgus (HP:0002967)1.65230653
111Low anterior hairline (HP:0000294)1.65023559
112Hypoplastic ischia (HP:0003175)1.64935590
113Aortic dissection (HP:0002647)1.64414987
114Urethral obstruction (HP:0000796)1.63644782
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.63106108
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.63106108
117Verrucae (HP:0200043)1.63066105
118Papilloma (HP:0012740)1.63066105
119Difficulty running (HP:0009046)1.62748027
120Abnormality of incisor morphology (HP:0011063)1.62721186
121Disinhibition (HP:0000734)1.62159732
122Stomach cancer (HP:0012126)1.61790261
123Back pain (HP:0003418)1.61765933
124Widely spaced teeth (HP:0000687)1.61205516
125Cutis marmorata (HP:0000965)1.61095543
126Broad metatarsal (HP:0001783)1.61084374
127Trigonocephaly (HP:0000243)1.61045163
128Hypoplastic labia majora (HP:0000059)1.60255494
129Supernumerary ribs (HP:0005815)1.60060939
130Truncal obesity (HP:0001956)1.59578672
131Abnormality of the radial head (HP:0003995)1.59238354
132Nephroblastoma (Wilms tumor) (HP:0002667)1.59097926
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.59029933
134Urinary bladder sphincter dysfunction (HP:0002839)1.58701127
135Recurrent viral infections (HP:0004429)1.57448260
136Germ cell neoplasia (HP:0100728)1.57184750
137Pointed chin (HP:0000307)1.55896362
138Abnormality of the labia majora (HP:0012881)1.55788919
139Deviation of the thumb (HP:0009603)1.54728688
140Striae distensae (HP:0001065)1.54233107
141Fibrous tissue neoplasm (HP:0012316)1.53865371
142Vascular tortuosity (HP:0004948)1.53023661
143Tibial bowing (HP:0002982)1.52862922
144Leiomyosarcoma (HP:0100243)1.52226280
145Uterine leiomyosarcoma (HP:0002891)1.52226280
146Colitis (HP:0002583)1.52131450
147Flat cornea (HP:0007720)1.51915347
148Cupped ear (HP:0000378)1.51461074
149Dislocated radial head (HP:0003083)1.50695199
150Insomnia (HP:0100785)1.50527688
151Deep philtrum (HP:0002002)1.50411433
152Generalized hypopigmentation of hair (HP:0011358)1.50202251
153Arnold-Chiari malformation (HP:0002308)1.50132108
154Broad palm (HP:0001169)1.49753432
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.49750727
156Broad ribs (HP:0000885)1.49589953
157Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49232986
158Aqueductal stenosis (HP:0002410)1.49067772
159Spontaneous hematomas (HP:0007420)1.48754242
160Abnormality of the astrocytes (HP:0100707)1.48356747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.19155200
2MAP3K103.13951549
3EEF2K3.06419615
4CDK122.95963884
5CASK2.78795392
6PKN22.58992685
7SGK22.43133618
8FGFR22.33900943
9MARK12.19794073
10PDGFRA2.19178247
11PTK62.19054042
12FGFR32.13682827
13AKT32.09480861
14RIPK11.99733407
15TNIK1.97182068
16CAMK1G1.94272726
17LATS11.83439853
18TAF11.71601160
19YES11.65937329
20MAPK151.65498343
21ALK1.65296372
22CAMK1D1.65002531
23SGK4941.62727659
24SGK2231.62727659
25EPHB11.59636921
26NLK1.59539211
27SIK11.57587114
28FRK1.57445000
29FGFR41.55688855
30MAP4K11.52890174
31BRD41.50652614
32PDGFRB1.50611870
33SCYL21.50490386
34TTN1.49723908
35SIK21.49100667
36STK101.47277115
37CDK61.46656214
38LRRK21.43881528
39TSSK61.31495190
40JAK11.30145810
41MAP3K41.27595060
42EPHA31.27177349
43RET1.22272661
44TYRO31.21828520
45ICK1.21593856
46MAP3K21.20093241
47ITK1.18015530
48PIK3CA1.17173507
49LATS21.16155397
50PRKCH1.15631601
51MTOR1.15099118
52HIPK21.14744374
53STK31.14471499
54NTRK21.10807540
55DMPK1.10332073
56PRPF4B1.04112316
57MAP3K70.98366892
58WNK10.97682274
59TGFBR20.94157137
60GRK60.94075783
61NEK60.89933776
62DDR20.88923260
63DYRK1A0.87810988
64CSK0.87700452
65BMX0.85198841
66PAK20.82690739
67FGFR10.82136405
68TAOK30.81470149
69SGK30.80513713
70STK38L0.77799131
71JAK30.77284964
72CAMKK20.76896028
73NTRK30.76659459
74JAK20.76426962
75SGK10.76092408
76RPS6KB10.75007898
77HCK0.74644906
78ERN10.73225455
79PASK0.71916657
80DYRK30.71658534
81MARK30.71369469
82UHMK10.70535455
83MKNK10.69709168
84MELK0.68505429
85PAK30.68437958
86CHUK0.68045909
87CDK90.67397104
88PTK20.67153462
89MAP2K40.66408837
90DYRK1B0.65784913
91CLK10.65281989
92TYK20.64912688
93CDK30.64581776
94INSRR0.64543841
95CAMKK10.64397148
96RPS6KB20.60730938
97FER0.57887126
98CSNK1A1L0.57478976
99CDC42BPA0.57165095
100PIM10.57160301
101PRKD10.57052309
102WNK30.56734078
103TRPM70.56290011
104CSNK1D0.55882242
105STK40.55773540
106MAPK130.55520980
107STK110.55440691
108CDK40.55267755
109MAP3K140.54094102
110IKBKE0.53085712
111EGFR0.52811558
112MAP3K60.51966656
113GSK3A0.51727245
114ERBB30.50883852
115FGR0.50449974
116CAMK40.50288187
117TEC0.49710483
118CSF1R0.48990168
119NEK90.48867742
120INSR0.48090552
121MAPK100.46061271
122IRAK10.45911169
123MKNK20.45823224
124KSR20.45184363
125ACVR1B0.43200722
126MARK20.42341969
127EPHB20.41653375
128STK240.41649146
129FYN0.40698290
130STK390.40676861
131LCK0.40175733
132BTK0.39850446
133PRKD20.39543107
134ZAP700.38893193
135PNCK0.38354667
136BRSK20.37646951
137RIPK40.37332420
138PAK40.37050046
139KSR10.36698709
140TGFBR10.36585100
141RPS6KA40.36556439
142PRKDC0.36007310
143RPS6KA20.35995103
144SRC0.35969474
145MAPK140.35877090
146PDK10.35742744
147ERBB20.35410324
148CHEK10.34322611
149TAOK10.34273329

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.78067780
2B cell receptor signaling pathway_Homo sapiens_hsa046621.65849210
3Adherens junction_Homo sapiens_hsa045201.57333210
4mTOR signaling pathway_Homo sapiens_hsa041501.47002910
5T cell receptor signaling pathway_Homo sapiens_hsa046601.46308592
6Dorso-ventral axis formation_Homo sapiens_hsa043201.44989055
7Type II diabetes mellitus_Homo sapiens_hsa049301.43682802
8Proteoglycans in cancer_Homo sapiens_hsa052051.40747306
9Endometrial cancer_Homo sapiens_hsa052131.37257841
10Focal adhesion_Homo sapiens_hsa045101.36331597
11MicroRNAs in cancer_Homo sapiens_hsa052061.36215522
12Lysine degradation_Homo sapiens_hsa003101.35375394
13Small cell lung cancer_Homo sapiens_hsa052221.33077700
14Osteoclast differentiation_Homo sapiens_hsa043801.31511305
15Viral myocarditis_Homo sapiens_hsa054161.30290891
16Thyroid cancer_Homo sapiens_hsa052161.30135196
17Pancreatic cancer_Homo sapiens_hsa052121.28494876
18Renal cell carcinoma_Homo sapiens_hsa052111.28077556
19Non-small cell lung cancer_Homo sapiens_hsa052231.26885015
20Colorectal cancer_Homo sapiens_hsa052101.26741514
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.25718537
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25443564
23Glioma_Homo sapiens_hsa052141.24233625
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.24161142
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24132149
26Insulin resistance_Homo sapiens_hsa049311.21881386
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21141996
28Cholinergic synapse_Homo sapiens_hsa047251.20138095
29Toxoplasmosis_Homo sapiens_hsa051451.19835241
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18895036
31Nitrogen metabolism_Homo sapiens_hsa009101.18037017
32Prostate cancer_Homo sapiens_hsa052151.16341308
33Estrogen signaling pathway_Homo sapiens_hsa049151.14338622
34Prolactin signaling pathway_Homo sapiens_hsa049171.11438498
35Nicotine addiction_Homo sapiens_hsa050331.10944569
36Primary immunodeficiency_Homo sapiens_hsa053401.10772480
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09677919
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09557234
39Platelet activation_Homo sapiens_hsa046111.07556048
40Alcoholism_Homo sapiens_hsa050341.06233318
41VEGF signaling pathway_Homo sapiens_hsa043701.03048971
42Antigen processing and presentation_Homo sapiens_hsa046121.02830104
43Gap junction_Homo sapiens_hsa045401.02611837
44Acute myeloid leukemia_Homo sapiens_hsa052211.00937722
45Chemokine signaling pathway_Homo sapiens_hsa040621.00874030
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00262386
47Hedgehog signaling pathway_Homo sapiens_hsa043400.98227766
48ECM-receptor interaction_Homo sapiens_hsa045120.98125190
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96822467
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.95510695
51Glutamatergic synapse_Homo sapiens_hsa047240.95366725
52FoxO signaling pathway_Homo sapiens_hsa040680.94478325
53Notch signaling pathway_Homo sapiens_hsa043300.92589701
54ErbB signaling pathway_Homo sapiens_hsa040120.92467812
55Leishmaniasis_Homo sapiens_hsa051400.91743312
56Amoebiasis_Homo sapiens_hsa051460.91692560
57Amphetamine addiction_Homo sapiens_hsa050310.91234370
58Hippo signaling pathway_Homo sapiens_hsa043900.90680812
59Hepatitis B_Homo sapiens_hsa051610.90207545
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88575571
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88535210
62Long-term depression_Homo sapiens_hsa047300.87958923
63Circadian entrainment_Homo sapiens_hsa047130.86844948
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86461214
65Melanoma_Homo sapiens_hsa052180.86256736
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86238712
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85984187
68Oxytocin signaling pathway_Homo sapiens_hsa049210.85103803
69Cocaine addiction_Homo sapiens_hsa050300.85077700
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85004296
71TNF signaling pathway_Homo sapiens_hsa046680.84676809
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84483998
73Axon guidance_Homo sapiens_hsa043600.83506708
74HTLV-I infection_Homo sapiens_hsa051660.82539990
75cAMP signaling pathway_Homo sapiens_hsa040240.82227587
76Basal cell carcinoma_Homo sapiens_hsa052170.81352045
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81333063
78Rap1 signaling pathway_Homo sapiens_hsa040150.80701576
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80420264
80Ras signaling pathway_Homo sapiens_hsa040140.80284995
81Pathways in cancer_Homo sapiens_hsa052000.79568343
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78851324
83Circadian rhythm_Homo sapiens_hsa047100.78651610
84MAPK signaling pathway_Homo sapiens_hsa040100.78174117
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77931514
86Renin secretion_Homo sapiens_hsa049240.76703508
87Morphine addiction_Homo sapiens_hsa050320.76682634
88Wnt signaling pathway_Homo sapiens_hsa043100.76557775
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.76478557
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.75580690
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75520143
92Systemic lupus erythematosus_Homo sapiens_hsa053220.75431842
93Measles_Homo sapiens_hsa051620.74642587
94Insulin signaling pathway_Homo sapiens_hsa049100.74599070
95AMPK signaling pathway_Homo sapiens_hsa041520.73946018
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73551380
97Dopaminergic synapse_Homo sapiens_hsa047280.73158767
98TGF-beta signaling pathway_Homo sapiens_hsa043500.72840443
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.72746565
100Choline metabolism in cancer_Homo sapiens_hsa052310.72479809
101Viral carcinogenesis_Homo sapiens_hsa052030.72467698
102Taste transduction_Homo sapiens_hsa047420.72140669
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.71718843
104Endocytosis_Homo sapiens_hsa041440.69849433
105GnRH signaling pathway_Homo sapiens_hsa049120.68951852
106Long-term potentiation_Homo sapiens_hsa047200.68843714
107Dilated cardiomyopathy_Homo sapiens_hsa054140.68581499
108GABAergic synapse_Homo sapiens_hsa047270.68537994
109Tight junction_Homo sapiens_hsa045300.67906239
110Gastric acid secretion_Homo sapiens_hsa049710.67373472
111Inositol phosphate metabolism_Homo sapiens_hsa005620.66007916
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65563553
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65094260
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64743923
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64365968
116Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64357495
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63515400
118mRNA surveillance pathway_Homo sapiens_hsa030150.63207533
119Melanogenesis_Homo sapiens_hsa049160.62969241
120Hepatitis C_Homo sapiens_hsa051600.62360726
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62310670
122Glucagon signaling pathway_Homo sapiens_hsa049220.60828575
123Apoptosis_Homo sapiens_hsa042100.60612224
124Tuberculosis_Homo sapiens_hsa051520.58466111
125Thyroid hormone synthesis_Homo sapiens_hsa049180.58385139
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57651275

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