DDX58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.70590654
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41004753
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41004753
4response to type I interferon (GO:0034340)5.32760902
5cellular response to type I interferon (GO:0071357)5.32661176
6type I interferon signaling pathway (GO:0060337)5.32661176
7antigen processing and presentation of endogenous antigen (GO:0019883)5.09590958
8response to interferon-alpha (GO:0035455)4.95582010
9* positive regulation of interferon-alpha production (GO:0032727)4.90095160
10positive regulation by symbiont of host defense response (GO:0052509)4.66554456
11modulation by symbiont of host defense response (GO:0052031)4.66554456
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.66554456
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.66554456
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.66554456
15modulation by symbiont of host immune response (GO:0052553)4.66554456
16* regulation of interferon-alpha production (GO:0032647)4.64539585
17positive regulation of gamma-delta T cell activation (GO:0046645)4.42693328
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.41919114
19immunoglobulin mediated immune response (GO:0016064)4.10442094
20regulation of interferon-beta biosynthetic process (GO:0045357)4.09881901
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.06755403
22negative regulation of cell killing (GO:0031342)4.06755403
23negative regulation of viral genome replication (GO:0045071)3.97322814
24response to peptidoglycan (GO:0032494)3.89824662
25positive regulation of type 2 immune response (GO:0002830)3.82890212
26interferon-gamma-mediated signaling pathway (GO:0060333)3.79354423
27response to interferon-beta (GO:0035456)3.77950819
28cellular response to interferon-alpha (GO:0035457)3.76924947
29regulation of RIG-I signaling pathway (GO:0039535)3.71519259
30response to host immune response (GO:0052572)3.62711451
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62711451
32regulation of viral genome replication (GO:0045069)3.62153080
33cellular response to exogenous dsRNA (GO:0071360)3.61887306
34cellular response to interferon-beta (GO:0035458)3.58077552
35* positive regulation of interferon-beta production (GO:0032728)3.57558409
36regulation of type I interferon-mediated signaling pathway (GO:0060338)3.53896677
37neutrophil activation involved in immune response (GO:0002283)3.53272565
38regulation of vitamin D biosynthetic process (GO:0060556)3.52700663
39negative regulation of viral process (GO:0048525)3.43203111
40T cell migration (GO:0072678)3.36877321
41negative regulation of T cell mediated immunity (GO:0002710)3.36350443
42regulation of type 2 immune response (GO:0002828)3.32301190
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30739628
44response to host (GO:0075136)3.30739628
45response to host defenses (GO:0052200)3.30739628
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.30539504
47detection of external biotic stimulus (GO:0098581)3.29949067
48positive regulation of natural killer cell differentiation (GO:0032825)3.29852565
49NIK/NF-kappaB signaling (GO:0038061)3.29003690
50negative regulation of cytokine production involved in immune response (GO:0002719)3.26986727
51germinal center formation (GO:0002467)3.22410002
52B cell mediated immunity (GO:0019724)3.21650417
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20409786
54macrophage activation involved in immune response (GO:0002281)3.20223073
55microglial cell activation (GO:0001774)3.16871872
56myeloid dendritic cell differentiation (GO:0043011)3.10612350
57regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.10425184
58regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.09542636
59regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.09523351
60regulation of gamma-delta T cell activation (GO:0046643)3.08693137
61regulation of cytokine secretion involved in immune response (GO:0002739)3.08649857
62defense response to protozoan (GO:0042832)3.07610690
63regulation of B cell receptor signaling pathway (GO:0050855)3.05384422
64regulation of chronic inflammatory response (GO:0002676)3.04922427
65macrophage activation (GO:0042116)3.04394533
66detection of bacterium (GO:0016045)3.03313764
67interferon-gamma secretion (GO:0072643)3.02973543
68positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.02437618
69defense response to virus (GO:0051607)3.01188583
70positive regulation of antigen processing and presentation (GO:0002579)3.00782130
71natural killer cell mediated immunity (GO:0002228)2.99982774
72natural killer cell mediated cytotoxicity (GO:0042267)2.99982774
73cellular response to interferon-gamma (GO:0071346)2.99932831
74leukocyte aggregation (GO:0070486)2.98812302
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97454149
76regulation of MHC class I biosynthetic process (GO:0045343)2.95977564
77respiratory burst (GO:0045730)2.95296399
78regulation of response to interferon-gamma (GO:0060330)2.93832560
79T-helper 1 type immune response (GO:0042088)2.93215871
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.91607232
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91325799
82regulation of gamma-delta T cell differentiation (GO:0045586)2.90851579
83response to muramyl dipeptide (GO:0032495)2.90113512
84neutrophil activation (GO:0042119)2.89792760
85regulation of T cell tolerance induction (GO:0002664)2.89587763
86lymphocyte chemotaxis (GO:0048247)2.89149651
87antigen processing and presentation via MHC class Ib (GO:0002475)2.87921700
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87919251
89detection of biotic stimulus (GO:0009595)2.87685015
90granulocyte activation (GO:0036230)2.87527950
91regulation of vitamin metabolic process (GO:0030656)2.87043946
92regulation of necroptotic process (GO:0060544)2.86391765
93interferon-gamma production (GO:0032609)2.85035550
94response to protozoan (GO:0001562)2.85032392
95regulation of interleukin-8 biosynthetic process (GO:0045414)2.84296696
96* cellular response to virus (GO:0098586)2.84097731
97positive regulation of humoral immune response (GO:0002922)2.83719713
98regulation of interleukin-12 production (GO:0032655)2.83616944
99regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82721783
100myeloid cell activation involved in immune response (GO:0002275)2.82001164
101* negative regulation of type I interferon production (GO:0032480)2.80212011
102negative regulation of type 2 immune response (GO:0002829)2.78268823
103regulation of T-helper 2 cell differentiation (GO:0045628)2.77397901
104positive regulation of NF-kappaB import into nucleus (GO:0042346)2.76775378
105positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76756983
106detection of molecule of bacterial origin (GO:0032490)2.75389381
107positive regulation of interleukin-12 production (GO:0032735)2.73361598
108positive regulation of chemokine biosynthetic process (GO:0045080)2.73344495
109negative regulation of defense response to virus (GO:0050687)2.72921002
110regulation of antigen processing and presentation (GO:0002577)2.71530764
111regulation of alpha-beta T cell proliferation (GO:0046640)2.70700835
112regulation of T-helper 1 cell differentiation (GO:0045625)2.70202031
113response to interferon-gamma (GO:0034341)2.69492486
114positive regulation of response to biotic stimulus (GO:0002833)2.69123224
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.67933611
116* regulation of interferon-beta production (GO:0032648)2.67667195
117negative regulation of myeloid cell apoptotic process (GO:0033033)2.66080165
118hydrogen peroxide biosynthetic process (GO:0050665)2.65963728
119positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.65858288
120I-kappaB phosphorylation (GO:0007252)2.62576987
121positive regulation of B cell differentiation (GO:0045579)2.60020128
122positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59589613
123positive regulation of cytokine biosynthetic process (GO:0042108)2.57775607
124superoxide anion generation (GO:0042554)2.57489254
125regulation of chemokine biosynthetic process (GO:0045073)2.56162707
126detection of other organism (GO:0098543)2.56140170
127negative regulation of lipid storage (GO:0010888)2.55901880
128regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55863339
129myeloid dendritic cell activation (GO:0001773)2.55701615
130production of molecular mediator involved in inflammatory response (GO:0002532)2.55654623
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55575766
132positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54219729
133negative regulation of interleukin-12 production (GO:0032695)2.53217839

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.72069289
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.84371425
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.64271398
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.95328282
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.93911964
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.26459904
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.61890451
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.53548142
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17682958
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01537150
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98629279
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96682306
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79801058
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.70644225
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66649110
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58256908
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34344142
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28153562
19GATA1_22025678_ChIP-Seq_K562_Human2.25050103
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16975456
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12705429
22RUNX_20019798_ChIP-Seq_JUKART_Human2.10562611
23MYB_26560356_Chip-Seq_TH2_Human2.02146856
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90958064
25SPI1_23547873_ChIP-Seq_NB4_Human1.90784532
26SCL_19346495_ChIP-Seq_HPC-7_Human1.89695770
27MYB_26560356_Chip-Seq_TH1_Human1.83656877
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81756356
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78360877
30MAF_26560356_Chip-Seq_TH1_Human1.77823314
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75428322
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70435449
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62761707
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61401298
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57045517
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.55866388
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.55522917
38PU_27001747_Chip-Seq_BMDM_Mouse1.53575879
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43478729
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41070800
41E2F7_22180533_ChIP-Seq_HELA_Human1.38657774
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.38161459
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36954914
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33287125
45VDR_24763502_ChIP-Seq_THP-1_Human1.32405016
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28729756
47UTX_26944678_Chip-Seq_JUKART_Human1.27826893
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26926033
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26253573
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.26155407
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22459666
52SPI1_23127762_ChIP-Seq_K562_Human1.19715923
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16819820
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16679626
55* GATA3_27048872_Chip-Seq_THYMUS_Human1.16217652
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15598794
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15432474
58* GATA3_26560356_Chip-Seq_TH2_Human1.13706453
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.08252094
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06622281
61MYC_22102868_ChIP-Seq_BL_Human1.06042431
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.04672031
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.04476980
64VDR_21846776_ChIP-Seq_THP-1_Human1.02894413
65VDR_24787735_ChIP-Seq_THP-1_Human1.02179304
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00303443
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00227779
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99794792
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99354835
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99169939
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98712913
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97588908
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96233583
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95717959
75MAF_26560356_Chip-Seq_TH2_Human0.95347018
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94352418
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93786231
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91982482
79TCF7_22412390_ChIP-Seq_EML_Mouse0.90285109
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88858746
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87374390
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86931271
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86881302
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86119764
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.84998550
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81571720
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79880065
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79736753
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79602446
90GATA1_19941826_ChIP-Seq_K562_Human0.78765874
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78460252
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78252060
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78047039
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78030763
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78030763
96HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77853538
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77529996
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75970137
99* CJUN_26792858_Chip-Seq_BT549_Human0.75211981
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75182876
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75159673
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74829025
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74377615
104FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74287136
105* SOX2_20726797_ChIP-Seq_SW620_Human0.73495765
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72773887
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.71782464
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.71263200
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.71092881
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.70666243
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.70614017
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.70425884
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.70126232
114TP53_16413492_ChIP-PET_HCT116_Human0.70078514
115SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69625500
116EGR1_19032775_ChIP-ChIP_M12_Human0.69385069
117TP63_23658742_ChIP-Seq_EP156T_Human0.67219265
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.63592378
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.62326323

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.29005868
2MP0009785_altered_susceptibility_to3.68699320
3MP0003724_increased_susceptibility_to3.36249818
4MP0003436_decreased_susceptibility_to3.00637182
5MP0005387_immune_system_phenotype2.94364599
6MP0001790_abnormal_immune_system2.94364599
7MP0005671_abnormal_response_to2.83503771
8MP0000685_abnormal_immune_system2.79993483
9* MP0005025_abnormal_response_to2.76304150
10MP0005000_abnormal_immune_tolerance2.74788001
11MP0002148_abnormal_hypersensitivity_rea2.73393268
12MP0006082_CNS_inflammation2.69678308
13MP0001800_abnormal_humoral_immune2.64367881
14MP0002419_abnormal_innate_immunity2.59736857
15* MP0002452_abnormal_antigen_presenting2.48483678
16* MP0002723_abnormal_immune_serum2.41085167
17* MP0001819_abnormal_immune_cell2.19885732
18* MP0002420_abnormal_adaptive_immunity2.17911437
19MP0003763_abnormal_thymus_physiology2.14336488
20MP0002166_altered_tumor_susceptibility2.11967839
21MP0003303_peritoneal_inflammation2.07446555
22MP0002006_tumorigenesis2.05971278
23MP0005451_abnormal_body_composition2.03606918
24MP0004947_skin_inflammation1.89514688
25MP0005464_abnormal_platelet_physiology1.88514261
26MP0004510_myositis1.85419341
27MP0001853_heart_inflammation1.84825809
28* MP0010155_abnormal_intestine_physiology1.82650802
29MP0002405_respiratory_system_inflammati1.82392787
30MP0006054_spinal_hemorrhage1.80270850
31MP0001533_abnormal_skeleton_physiology1.79131803
32* MP0001845_abnormal_inflammatory_respons1.79063244
33MP0002332_abnormal_exercise_endurance1.78963441
34MP0009764_decreased_sensitivity_to1.77483965
35MP0008004_abnormal_stomach_pH1.74493415
36* MP0002398_abnormal_bone_marrow1.73579261
37* MP0000716_abnormal_immune_system1.72988956
38MP0002138_abnormal_hepatobiliary_system1.68151478
39* MP0008469_abnormal_protein_level1.67324580
40MP0003300_gastrointestinal_ulcer1.65819534
41MP0003191_abnormal_cellular_cholesterol1.62050913
42MP0008260_abnormal_autophagy1.56172439
43MP0005257_abnormal_intraocular_pressure1.54580389
44MP0005058_abnormal_lysosome_morphology1.49211725
45MP0001545_abnormal_hematopoietic_system1.48261105
46MP0005397_hematopoietic_system_phenotyp1.48261105
47MP0003448_altered_tumor_morphology1.46468577
48MP0009333_abnormal_splenocyte_physiolog1.46412990
49MP0009278_abnormal_bone_marrow1.46335163
50* MP0000689_abnormal_spleen_morphology1.45171102
51* MP0002429_abnormal_blood_cell1.41427389
52MP0004883_abnormal_blood_vessel1.36033588
53MP0000858_altered_metastatic_potential1.34295151
54* MP0002722_abnormal_immune_system1.33654060
55MP0002396_abnormal_hematopoietic_system1.30974938
56MP0000343_altered_response_to1.30427372
57MP0001873_stomach_inflammation1.29633067
58MP0004782_abnormal_surfactant_physiolog1.27521206
59MP0002998_abnormal_bone_remodeling1.24636297
60MP0009840_abnormal_foam_cell1.20485340
61MP0004808_abnormal_hematopoietic_stem1.19163476
62MP0002933_joint_inflammation1.18943185
63MP0003690_abnormal_glial_cell1.16381428
64MP0009763_increased_sensitivity_to1.16179046
65MP0002254_reproductive_system_inflammat1.14536348
66MP0000604_amyloidosis1.13363651
67MP0010352_gastrointestinal_tract_polyps1.13087107
68MP0008438_abnormal_cutaneous_collagen1.11930869
69MP0005310_abnormal_salivary_gland1.11251924
70MP0003566_abnormal_cell_adhesion1.07175550
71MP0000465_gastrointestinal_hemorrhage1.06253453
72MP0003186_abnormal_redox_activity1.06051106
73MP0003656_abnormal_erythrocyte_physiolo1.05777848
74MP0005360_urolithiasis1.04111560
75MP0005023_abnormal_wound_healing1.03289315
76MP0003221_abnormal_cardiomyocyte_apopto1.02856757
77MP0003453_abnormal_keratinocyte_physiol1.02118162
78MP0002277_abnormal_respiratory_mucosa1.00943411
79MP0010307_abnormal_tumor_latency0.96301901
80MP0000703_abnormal_thymus_morphology0.95887921
81MP0003172_abnormal_lysosome_physiology0.94680106
82MP0005390_skeleton_phenotype0.92298489
83MP0003828_pulmonary_edema0.89142674
84MP0000490_abnormal_crypts_of0.89016210
85MP0003183_abnormal_peptide_metabolism0.87665451
86MP0002139_abnormal_hepatobiliary_system0.84851536
87MP0001542_abnormal_bone_strength0.83330007
88MP0003091_abnormal_cell_migration0.80997519
89MP0000569_abnormal_digit_pigmentation0.79546472
90MP0003075_altered_response_to0.79100180
91MP0000609_abnormal_liver_physiology0.78349449
92MP0001851_eye_inflammation0.77615618
93MP0003806_abnormal_nucleotide_metabolis0.77371284
94MP0005166_decreased_susceptibility_to0.75681211
95MP0001958_emphysema0.74837412
96MP0003866_abnormal_defecation0.74252090
97MP0000249_abnormal_blood_vessel0.74219677
98MP0002136_abnormal_kidney_physiology0.73653528
99MP0005174_abnormal_tail_pigmentation0.71931217
100MP0009765_abnormal_xenobiotic_induced0.71366848
101MP0005164_abnormal_response_to0.70270486
102MP0005165_increased_susceptibility_to0.69993665
103MP0005319_abnormal_enzyme/_coenzyme0.69647269
104MP0001663_abnormal_digestive_system0.68378033
105MP0003045_fibrosis0.67455130
106MP0000371_diluted_coat_color0.67198650
107MP0003795_abnormal_bone_structure0.67126242
108MP0000767_abnormal_smooth_muscle0.65528550
109* MP0002019_abnormal_tumor_incidence0.64669221
110MP0003646_muscle_fatigue0.64665023
111MP0003252_abnormal_bile_duct0.64300557
112MP0002877_abnormal_melanocyte_morpholog0.63550660
113MP0005167_abnormal_blood-brain_barrier0.63309893
114MP0008874_decreased_physiological_sensi0.63264311
115MP0002132_abnormal_respiratory_system0.61162603
116* MP0000598_abnormal_liver_morphology0.59635931
117MP0003195_calcinosis0.58456768
118MP0001879_abnormal_lymphatic_vessel0.57433267
119MP0005376_homeostasis/metabolism_phenot0.56524645
120MP0005266_abnormal_metabolism0.52358955

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.42270665
2Recurrent abscess formation (HP:0002722)5.23367268
3Recurrent bacterial skin infections (HP:0005406)4.82963356
4Elevated erythrocyte sedimentation rate (HP:0003565)4.60035327
5Autoimmune thrombocytopenia (HP:0001973)4.25807287
6Myositis (HP:0100614)4.24802980
7Recurrent gram-negative bacterial infections (HP:0005420)4.23332748
8Abnormality of glycolipid metabolism (HP:0010969)3.90226817
9Abnormality of liposaccharide metabolism (HP:0010968)3.90226817
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.90226817
11Chronic otitis media (HP:0000389)3.80859310
12Orchitis (HP:0100796)3.80349379
13Recurrent fungal infections (HP:0002841)3.71132863
14Vasculitis (HP:0002633)3.63153252
15Recurrent viral infections (HP:0004429)3.61047201
16Abnormality of macrophages (HP:0004311)3.60391576
17Mediastinal lymphadenopathy (HP:0100721)3.58335829
18Optic neuritis (HP:0100653)3.51890689
19Retrobulbar optic neuritis (HP:0100654)3.51890689
20Recurrent skin infections (HP:0001581)3.45788220
21Increased IgM level (HP:0003496)3.22768461
22Recurrent bronchitis (HP:0002837)3.20068996
23Peritonitis (HP:0002586)3.17703178
24Chronic mucocutaneous candidiasis (HP:0002728)3.15829649
25Recurrent cutaneous fungal infections (HP:0011370)3.15829649
26Systemic lupus erythematosus (HP:0002725)3.09279527
27Gingivitis (HP:0000230)3.04965963
28Pustule (HP:0200039)2.96213171
29Gangrene (HP:0100758)2.95194765
30Loss of speech (HP:0002371)2.93425136
31Basal ganglia calcification (HP:0002135)2.89597881
32Gingival bleeding (HP:0000225)2.88930140
33Vacuolated lymphocytes (HP:0001922)2.88793380
34Periodontitis (HP:0000704)2.85166161
35Stomatitis (HP:0010280)2.82234047
36IgM deficiency (HP:0002850)2.80010644
37Interstitial pulmonary disease (HP:0006530)2.77652257
38Arterial thrombosis (HP:0004420)2.77361435
39Autoimmune hemolytic anemia (HP:0001890)2.73084150
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72313278
41Keratitis (HP:0000491)2.72161588
42Hypergammaglobulinemia (HP:0010702)2.71607515
43Petechiae (HP:0000967)2.70230809
44Meningitis (HP:0001287)2.69732995
45Nasal polyposis (HP:0100582)2.68471181
46Abnormality of the nasal mucosa (HP:0000433)2.66484488
47Chronic obstructive pulmonary disease (HP:0006510)2.66358023
48Obstructive lung disease (HP:0006536)2.66358023
49Pulmonary infiltrates (HP:0002113)2.64055093
50Myocardial infarction (HP:0001658)2.63801773
51Amyloidosis (HP:0011034)2.62770669
52Abnormality of T cell number (HP:0011839)2.60996041
53Cellulitis (HP:0100658)2.60089008
54Tetraparesis (HP:0002273)2.59846562
55Prostate neoplasm (HP:0100787)2.58247066
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.56167253
57Joint hemorrhage (HP:0005261)2.55790851
58Chronic diarrhea (HP:0002028)2.54357269
59Spontaneous hematomas (HP:0007420)2.53104011
60Hemoptysis (HP:0002105)2.51993587
61Abnormality of T cells (HP:0002843)2.48075987
62Disinhibition (HP:0000734)2.46403742
63Abnormality of the pleura (HP:0002103)2.44975966
64Thrombocytosis (HP:0001894)2.44485712
65T lymphocytopenia (HP:0005403)2.44021497
66Colitis (HP:0002583)2.43054172
67Osteomyelitis (HP:0002754)2.41860807
68IgA deficiency (HP:0002720)2.41535669
69Hematochezia (HP:0002573)2.40323319
70Leukocytosis (HP:0001974)2.38143171
71Abnormality of T cell physiology (HP:0011840)2.37324632
72Dysostosis multiplex (HP:0000943)2.36309252
73Recurrent pneumonia (HP:0006532)2.35640462
74Prolonged bleeding time (HP:0003010)2.35528863
75Pulmonary embolism (HP:0002204)2.34422727
76Lymphopenia (HP:0001888)2.33988307
77Inflammation of the large intestine (HP:0002037)2.33507466
78Abnormality of the pericardium (HP:0001697)2.33395226
79Eosinophilia (HP:0001880)2.33191989
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.32899812
81Keratoconjunctivitis sicca (HP:0001097)2.32264986
82Abnormality of the prostate (HP:0008775)2.31625735
83Joint swelling (HP:0001386)2.29798004
84Abnormality of the endocardium (HP:0004306)2.29425132
85Epistaxis (HP:0000421)2.28552578
86Porencephaly (HP:0002132)2.25688995
87Chest pain (HP:0100749)2.24512776
88Recurrent lower respiratory tract infections (HP:0002783)2.23308592
89Abnormality of B cell number (HP:0010975)2.22427383
90Abnormality of the fingertips (HP:0001211)2.21079350
91Agammaglobulinemia (HP:0004432)2.20674115
92Gastrointestinal infarctions (HP:0005244)2.19181405
93Anorexia (HP:0002039)2.17454865
94IgG deficiency (HP:0004315)2.17329625
95Gastrointestinal stroma tumor (HP:0100723)2.16768947
96Emphysema (HP:0002097)2.16764323
97Osteolytic defects of the hand bones (HP:0009699)2.16144532
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.16144532
99Urticaria (HP:0001025)2.14371910
100Gastrointestinal inflammation (HP:0004386)2.13768974
101Granulocytopenia (HP:0001913)2.13668883
102Glomerulopathy (HP:0100820)2.13132572
103Keratoconjunctivitis (HP:0001096)2.12784553
104Encephalitis (HP:0002383)2.12697734
105Episodic fever (HP:0001954)2.12345359
106Vertebral compression fractures (HP:0002953)2.11491522
107Polyneuropathy (HP:0001271)2.10941557
108Skin ulcer (HP:0200042)2.08213915
109Increased IgE level (HP:0003212)2.06591417
110Chronic sinusitis (HP:0011109)2.06420054
111Abnormality of eosinophils (HP:0001879)2.05787382
112Vertigo (HP:0002321)2.04064038
113Hemorrhage of the eye (HP:0011885)2.03461675
114Parakeratosis (HP:0001036)2.02107321
115Thick nail (HP:0001805)2.01020174
116Panhypogammaglobulinemia (HP:0003139)1.99754398
117Purpura (HP:0000979)1.98154468
118Esophageal varix (HP:0002040)1.98049566
119Increased cerebral lipofuscin (HP:0011813)1.98032062
120Cheilitis (HP:0100825)1.97792682
121Acne (HP:0001061)1.95799653
122Thyroiditis (HP:0100646)1.95369626
123Abnormality of the peritoneum (HP:0002585)1.95095345
124Nephritis (HP:0000123)1.94049278
125Abnormal platelet volume (HP:0011876)1.93873251
126Spondylolisthesis (HP:0003302)1.93798065
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92154305
128Neoplasm of the tracheobronchial system (HP:0100552)1.91930920
129B lymphocytopenia (HP:0010976)1.91825079
130Subacute progressive viral hepatitis (HP:0006572)1.90434997
131Arthralgia (HP:0002829)1.90353854
132Abnormality of polysaccharide metabolism (HP:0011012)1.87672601
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87672601
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87672601
135Progressive neurologic deterioration (HP:0002344)1.80208143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.87008880
2IKBKE3.67977579
3MAP3K143.64727243
4TBK13.31233782
5TXK3.19705161
6MAP4K13.19496564
7JAK33.11524235
8KIT2.76682808
9IRAK42.76116911
10FGFR42.74674059
11JAK12.62366756
12IRAK32.52696275
13GRK72.37607180
14BLK2.25783203
15IKBKB2.04668233
16ERN12.00440778
17FGFR31.93025697
18ZAP701.74631008
19CSK1.68701422
20MAP3K131.68110675
21PRPF4B1.67719361
22IRAK21.64972892
23TAOK21.57501898
24TEC1.53331159
25TGFBR21.47589401
26CHUK1.43070803
27BTK1.41771179
28EPHA31.40115515
29MOS1.36993893
30FLT31.29961024
31CSF1R1.29464953
32RPS6KA41.26032167
33TAOK11.25388942
34PTK2B1.25249419
35NLK1.24497889
36HCK1.24088655
37SYK1.21469837
38HIPK21.19170583
39LCK1.18979591
40STK101.18410605
41NME21.18361676
42PBK1.13610014
43PIM21.13346420
44NEK91.12856545
45RIPK41.12805292
46TRPM71.09647926
47PIM11.08798300
48TAOK31.08659575
49DDR21.02137220
50LYN1.00698592
51MAP3K11.00416400
52ITK0.95462317
53ACVR1B0.94722513
54MATK0.94662046
55KDR0.92556449
56MAP3K110.91229746
57JAK20.91135051
58MST40.90534226
59RIPK10.90266539
60CDC42BPA0.88043695
61ZAK0.87825752
62EIF2AK20.86403493
63IRAK10.86101026
64PLK40.85528590
65EPHB10.81570142
66NUAK10.80734127
67STK40.75826690
68FRK0.75051065
69MAPK110.71458893
70MAP3K60.70840005
71BMPR20.70754308
72MAP2K30.70486425
73STK30.66202914
74TGFBR10.65487485
75PIK3CG0.63332414
76MARK30.62128473
77TIE10.61752295
78ERBB30.61733946
79SIK30.61580324
80GRK60.59263894
81SIK10.57737799
82CLK10.57661552
83CAMK1D0.56055822
84MAPK70.55972747
85BMX0.54571295
86TTN0.52074395
87EEF2K0.52065203
88YES10.48983500
89KSR20.48398940
90PTK60.47346277
91CAMKK20.47178803
92ABL10.47086461
93RPS6KA50.47011480
94PRKCD0.42784783
95MARK20.42689268
96PDK10.42370644
97RPS6KA60.42284235
98MAP3K20.41414525
99MAP3K30.41354976
100ADRBK20.39968070
101FGR0.39309137
102PRKG20.39124287
103TNK20.39104201
104PKN20.38970147
105EGFR0.38956108
106MELK0.38887656
107FES0.37537204
108PDGFRB0.37413876
109LRRK20.36987347
110CDK60.35803937
111CDK120.35467381
112MAP2K60.34707532
113PRKCQ0.34565446
114FYN0.33832931
115RPS6KB20.33433828
116SIK20.33284907
117IGF1R0.32958288
118DYRK30.31607021
119CDK90.31134523
120MAP3K50.29811414
121CDK40.29535333
122GRK10.29373741
123MAPKAPK20.28827332
124PRKCH0.27228298
125ATR0.27153862
126STK240.26826170
127KSR10.26647656
128FER0.26061824
129PDPK10.24737728
130PRKD20.23339358
131RAF10.22780972
132INSR0.21488678
133TESK20.21243641
134GRK50.19637197
135SGK30.19292839

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.91300870
2* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81862404
3* NF-kappa B signaling pathway_Homo sapiens_hsa040642.81267576
4Staphylococcus aureus infection_Homo sapiens_hsa051502.74598818
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73125433
6* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.65515768
7* Measles_Homo sapiens_hsa051622.65205944
8Graft-versus-host disease_Homo sapiens_hsa053322.47210260
9Allograft rejection_Homo sapiens_hsa053302.46390166
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.42220351
11Primary immunodeficiency_Homo sapiens_hsa053402.42171701
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40582958
13* Herpes simplex infection_Homo sapiens_hsa051682.08725378
14* Influenza A_Homo sapiens_hsa051642.06198215
15Malaria_Homo sapiens_hsa051442.06081348
16Osteoclast differentiation_Homo sapiens_hsa043802.03400909
17Asthma_Homo sapiens_hsa053101.99247343
18Legionellosis_Homo sapiens_hsa051341.96291788
19Hematopoietic cell lineage_Homo sapiens_hsa046401.87594912
20TNF signaling pathway_Homo sapiens_hsa046681.84951830
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82640601
22Antigen processing and presentation_Homo sapiens_hsa046121.82302845
23Pertussis_Homo sapiens_hsa051331.81895282
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.67807023
25Toxoplasmosis_Homo sapiens_hsa051451.59914022
26B cell receptor signaling pathway_Homo sapiens_hsa046621.56806288
27Tuberculosis_Homo sapiens_hsa051521.52163466
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49616527
29Caffeine metabolism_Homo sapiens_hsa002321.47312082
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47139820
31* Hepatitis C_Homo sapiens_hsa051601.34596870
32Apoptosis_Homo sapiens_hsa042101.31417598
33Autoimmune thyroid disease_Homo sapiens_hsa053201.30872442
34African trypanosomiasis_Homo sapiens_hsa051431.28511192
35* Hepatitis B_Homo sapiens_hsa051611.25479245
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23284075
37Rheumatoid arthritis_Homo sapiens_hsa053231.22301109
38Chemokine signaling pathway_Homo sapiens_hsa040621.17103682
39Complement and coagulation cascades_Homo sapiens_hsa046101.15945924
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12002774
41Salmonella infection_Homo sapiens_hsa051321.09721182
42Viral myocarditis_Homo sapiens_hsa054161.07764750
43T cell receptor signaling pathway_Homo sapiens_hsa046601.07651345
44Type I diabetes mellitus_Homo sapiens_hsa049401.05082651
45Other glycan degradation_Homo sapiens_hsa005111.02522813
46Shigellosis_Homo sapiens_hsa051310.98336670
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.92441453
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.91546299
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89760642
50Acute myeloid leukemia_Homo sapiens_hsa052210.87754583
51Lysosome_Homo sapiens_hsa041420.86472939
52Prolactin signaling pathway_Homo sapiens_hsa049170.79553923
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77770651
54Phagosome_Homo sapiens_hsa041450.77164254
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75694981
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75083292
57Small cell lung cancer_Homo sapiens_hsa052220.70656395
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68821936
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.66822294
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66751462
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63967229
62Pancreatic cancer_Homo sapiens_hsa052120.63277669
63Amoebiasis_Homo sapiens_hsa051460.62599412
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60192728
65Dorso-ventral axis formation_Homo sapiens_hsa043200.60004790
66ABC transporters_Homo sapiens_hsa020100.59396674
67Chronic myeloid leukemia_Homo sapiens_hsa052200.57923246
68* Epstein-Barr virus infection_Homo sapiens_hsa051690.57378461
69VEGF signaling pathway_Homo sapiens_hsa043700.56871940
70Bladder cancer_Homo sapiens_hsa052190.55574309
71p53 signaling pathway_Homo sapiens_hsa041150.55546154
72Viral carcinogenesis_Homo sapiens_hsa052030.54208953
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52715411
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52435288
75Platelet activation_Homo sapiens_hsa046110.50923720
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50461757
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.48408995
78Non-small cell lung cancer_Homo sapiens_hsa052230.48387668
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47687557
80HTLV-I infection_Homo sapiens_hsa051660.47321872
81One carbon pool by folate_Homo sapiens_hsa006700.45301422
82Notch signaling pathway_Homo sapiens_hsa043300.44139868
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.40714525
84Type II diabetes mellitus_Homo sapiens_hsa049300.39377031
85Insulin resistance_Homo sapiens_hsa049310.38341972
86Renal cell carcinoma_Homo sapiens_hsa052110.38009819
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.37854312
88Endocytosis_Homo sapiens_hsa041440.37116303
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.36508738
90Proteoglycans in cancer_Homo sapiens_hsa052050.35264110
91Peroxisome_Homo sapiens_hsa041460.34987962
92Sphingolipid metabolism_Homo sapiens_hsa006000.34443490
93Starch and sucrose metabolism_Homo sapiens_hsa005000.34093505
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32403988
95Chemical carcinogenesis_Homo sapiens_hsa052040.31387593
96Vitamin digestion and absorption_Homo sapiens_hsa049770.31083369
97Adherens junction_Homo sapiens_hsa045200.30897236
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30667189
99Prostate cancer_Homo sapiens_hsa052150.28877544
100FoxO signaling pathway_Homo sapiens_hsa040680.26429585
101Tryptophan metabolism_Homo sapiens_hsa003800.25899472
102Histidine metabolism_Homo sapiens_hsa003400.25392624
103Folate biosynthesis_Homo sapiens_hsa007900.24103097
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.23124467
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23018750
106HIF-1 signaling pathway_Homo sapiens_hsa040660.22892844
107mTOR signaling pathway_Homo sapiens_hsa041500.22713427
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22489803
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22400375
110PPAR signaling pathway_Homo sapiens_hsa033200.21992971
111Base excision repair_Homo sapiens_hsa034100.21726600
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21694206
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21513992
114MicroRNAs in cancer_Homo sapiens_hsa052060.21066505
115Systemic lupus erythematosus_Homo sapiens_hsa053220.20264498
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.20073910
117Non-homologous end-joining_Homo sapiens_hsa034500.19782433
118Prion diseases_Homo sapiens_hsa050200.19740820
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19675670
120MAPK signaling pathway_Homo sapiens_hsa040100.18741889
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18683834
122Endometrial cancer_Homo sapiens_hsa052130.16837323
123Pathways in cancer_Homo sapiens_hsa052000.14309762
124Fatty acid biosynthesis_Homo sapiens_hsa000610.12588817

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