DDX56

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.38922303
2purine nucleobase biosynthetic process (GO:0009113)5.18148020
3DNA strand elongation involved in DNA replication (GO:0006271)4.88390752
4DNA strand elongation (GO:0022616)4.71662869
5telomere maintenance via semi-conservative replication (GO:0032201)4.65398489
6formation of translation preinitiation complex (GO:0001731)4.62460712
7IMP biosynthetic process (GO:0006188)4.48053936
8ribosome assembly (GO:0042255)4.43748576
9ribosome biogenesis (GO:0042254)4.41442064
10DNA replication initiation (GO:0006270)4.40530967
11GDP-mannose metabolic process (GO:0019673)4.39291437
12maturation of SSU-rRNA (GO:0030490)4.39270418
13ribosomal small subunit assembly (GO:0000028)4.36381298
14regulation of translational fidelity (GO:0006450)4.29418899
15telomere maintenance via recombination (GO:0000722)4.13287521
16DNA unwinding involved in DNA replication (GO:0006268)4.10180812
17mitotic metaphase plate congression (GO:0007080)4.06593922
18proline biosynthetic process (GO:0006561)4.03526598
19DNA deamination (GO:0045006)4.02233030
20proteasome assembly (GO:0043248)3.96074147
21ribonucleoprotein complex biogenesis (GO:0022613)3.95084425
22folic acid-containing compound biosynthetic process (GO:0009396)3.93955023
23ribosomal large subunit biogenesis (GO:0042273)3.92587620
24IMP metabolic process (GO:0046040)3.86589672
25mitotic recombination (GO:0006312)3.85715084
26COPI coating of Golgi vesicle (GO:0048205)3.85489881
27Golgi transport vesicle coating (GO:0048200)3.85489881
28protein localization to kinetochore (GO:0034501)3.85291617
29telomere maintenance via telomere lengthening (GO:0010833)3.84888926
30regulation of mitochondrial translation (GO:0070129)3.84110840
31DNA replication checkpoint (GO:0000076)3.82217738
32rRNA modification (GO:0000154)3.81949572
33mitotic nuclear envelope disassembly (GO:0007077)3.81923813
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74370870
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72743300
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66375993
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66214919
38DNA replication-dependent nucleosome organization (GO:0034723)3.63349219
39DNA replication-dependent nucleosome assembly (GO:0006335)3.63349219
40* rRNA processing (GO:0006364)3.59220203
41spliceosomal snRNP assembly (GO:0000387)3.58850713
42mitotic chromosome condensation (GO:0007076)3.55680344
43L-serine metabolic process (GO:0006563)3.55174559
44CENP-A containing nucleosome assembly (GO:0034080)3.53688760
45nucleobase-containing small molecule interconversion (GO:0015949)3.53511733
46membrane disassembly (GO:0030397)3.52509036
47nuclear envelope disassembly (GO:0051081)3.52509036
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.50668943
49folic acid metabolic process (GO:0046655)3.49061817
50chromatin remodeling at centromere (GO:0031055)3.46108439
51* rRNA metabolic process (GO:0016072)3.45788772
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.45637281
53pseudouridine synthesis (GO:0001522)3.42954695
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40293533
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39976187
56negative regulation of ligase activity (GO:0051352)3.39976187
57nuclear pore organization (GO:0006999)3.38840838
58tRNA methylation (GO:0030488)3.34865299
59transcription-coupled nucleotide-excision repair (GO:0006283)3.33569419
60peptidyl-arginine omega-N-methylation (GO:0035247)3.32866243
61metaphase plate congression (GO:0051310)3.32229826
62viral mRNA export from host cell nucleus (GO:0046784)3.29290553
63establishment of integrated proviral latency (GO:0075713)3.27310735
64DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26824333
65protein localization to chromosome, centromeric region (GO:0071459)3.26323108
66DNA replication-independent nucleosome organization (GO:0034724)3.23827088
67DNA replication-independent nucleosome assembly (GO:0006336)3.23827088
68G1/S transition of mitotic cell cycle (GO:0000082)3.22967334
69cell cycle G1/S phase transition (GO:0044843)3.22967334
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22528579
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22528579
72signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22528579
73translational initiation (GO:0006413)3.22411070
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22383068
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22383068
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.22224722
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22224722
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21517365
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21433241
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.21433241
81negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20863711
82cullin deneddylation (GO:0010388)3.20695791
83rRNA transcription (GO:0009303)3.20009411
84mitotic nuclear envelope reassembly (GO:0007084)3.18067403
85nuclear envelope reassembly (GO:0031468)3.18067403
86protein maturation by protein folding (GO:0022417)3.17277203
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.17058335
88protein deneddylation (GO:0000338)3.16957278
89maturation of 5.8S rRNA (GO:0000460)3.15419385
90rRNA methylation (GO:0031167)3.14591705
91regulation of spindle organization (GO:0090224)3.13901152
92viral transcription (GO:0019083)3.11630721
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.10793698
94translational termination (GO:0006415)3.10462030
95guanosine-containing compound biosynthetic process (GO:1901070)3.09859044
96mitochondrial RNA metabolic process (GO:0000959)3.09849134
97translational elongation (GO:0006414)3.08952612
98regulation of cellular amino acid metabolic process (GO:0006521)3.08520395
99ribosomal small subunit biogenesis (GO:0042274)3.08460642
100mitotic sister chromatid segregation (GO:0000070)3.07333737
101regulation of mitotic spindle organization (GO:0060236)3.06624465
102regulation of translational termination (GO:0006449)3.06430300
103deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06119662
104establishment of chromosome localization (GO:0051303)3.05731117
105positive regulation of ligase activity (GO:0051351)3.05381015
106regulation of double-strand break repair via homologous recombination (GO:0010569)3.02997150
107transcription elongation from RNA polymerase III promoter (GO:0006385)3.02622857
108termination of RNA polymerase III transcription (GO:0006386)3.02622857
109cellular component biogenesis (GO:0044085)3.01096067
110establishment of viral latency (GO:0019043)2.98534405
111attachment of spindle microtubules to kinetochore (GO:0008608)2.98018210
112tRNA aminoacylation for protein translation (GO:0006418)2.97275972
113histone exchange (GO:0043486)2.95607577
114spliceosomal complex assembly (GO:0000245)2.93809298
115telomere organization (GO:0032200)2.93345129
116termination of RNA polymerase I transcription (GO:0006363)2.93185801
117telomere maintenance (GO:0000723)2.92485710
1187-methylguanosine mRNA capping (GO:0006370)2.91415727
119nuclear pore complex assembly (GO:0051292)2.91326765
120pentose-phosphate shunt (GO:0006098)2.91271929
121sister chromatid segregation (GO:0000819)2.90301541
122protein retention in ER lumen (GO:0006621)2.90068585
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89637661
124regulation of ubiquitin-protein transferase activity (GO:0051438)2.89307183
125amino acid activation (GO:0043038)2.89075894
126tRNA aminoacylation (GO:0043039)2.89075894
127pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88348696
128translation (GO:0006412)2.88041429
129regulation of ligase activity (GO:0051340)2.88033863
130transcription from RNA polymerase I promoter (GO:0006360)2.87398082
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86434216
132pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85527966
133DNA duplex unwinding (GO:0032508)2.83135171
134transcription from mitochondrial promoter (GO:0006390)2.81631513
135nucleoside salvage (GO:0043174)2.81628461
136base-excision repair (GO:0006284)2.79098122
137protein complex localization (GO:0031503)2.76069761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27682177
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33424742
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.94868865
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43519418
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.29696982
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23871617
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20087331
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.17670579
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.07196048
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03744360
11* GABP_17652178_ChIP-ChIP_JURKAT_Human3.02431039
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02099976
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92178136
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.84038797
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81084902
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72662655
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58688419
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36604886
19XRN2_22483619_ChIP-Seq_HELA_Human2.36108724
20VDR_23849224_ChIP-Seq_CD4+_Human2.28598814
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.24759029
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15286485
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14755494
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11695494
25DCP1A_22483619_ChIP-Seq_HELA_Human2.09025087
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08653686
27FOXP3_21729870_ChIP-Seq_TREG_Human2.06547372
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05762636
29* GABP_19822575_ChIP-Seq_HepG2_Human2.00883028
30AR_21909140_ChIP-Seq_LNCAP_Human1.93207100
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92495304
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90359286
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88691712
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88075725
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86642656
36* VDR_21846776_ChIP-Seq_THP-1_Human1.82391481
37TTF2_22483619_ChIP-Seq_HELA_Human1.78212645
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.74757841
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74070441
40ZNF263_19887448_ChIP-Seq_K562_Human1.73929448
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72517464
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.70295442
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66880801
44CIITA_25753668_ChIP-Seq_RAJI_Human1.66038984
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62594767
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.61210493
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60294426
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55425657
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55051398
50ELK1_19687146_ChIP-ChIP_HELA_Human1.53959599
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52141892
52KDM5A_27292631_Chip-Seq_BREAST_Human1.50375551
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47954080
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46145172
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45870742
56LXR_22292898_ChIP-Seq_THP-1_Human1.45578002
57MYC_22102868_ChIP-Seq_BL_Human1.43474758
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.42310074
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40275112
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39988435
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39524702
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.39330110
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37943955
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35335499
65* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34770812
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.33250748
67RACK7_27058665_Chip-Seq_MCF-7_Human1.32139343
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30694354
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30662496
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30025294
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29223359
72* P68_20966046_ChIP-Seq_HELA_Human1.28264310
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24304749
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23878209
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23741902
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.22454293
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21888345
78TFEB_21752829_ChIP-Seq_HELA_Human1.20713249
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19298676
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14735767
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13401863
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10527511
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10488665
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09929036
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.09104089
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08892445
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08066147
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05956713
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05505141
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05213972
91ATF3_27146783_Chip-Seq_COLON_Human1.04772296
92TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03628827
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03160765
94MAF_26560356_Chip-Seq_TH2_Human1.02621271
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.02407676
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01642854
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01619051
98* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01476015
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01188359
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00555002
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99392865
102TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99341510
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98933668
104CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98755924
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98344340
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.97814129
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97580646
108SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95865086
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95710334
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.93983453
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93277394
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93220015
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92421591
114ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90555775
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89416654
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.88287690
117MYC_18940864_ChIP-ChIP_HL60_Human0.86952534
118* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86741206
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85542924
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85493727
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85472993
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85282546
123NANOG_21062744_ChIP-ChIP_HESCs_Human0.83948104
124SPI1_23547873_ChIP-Seq_NB4_Human0.83278224
125* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80992350
126NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80149353
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79829255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.96242160
2MP0003111_abnormal_nucleus_morphology4.91933649
3MP0010094_abnormal_chromosome_stability4.91465817
4MP0004957_abnormal_blastocyst_morpholog4.74051029
5MP0003077_abnormal_cell_cycle4.16803859
6MP0008057_abnormal_DNA_replication4.00855987
7MP0008058_abnormal_DNA_repair3.86381504
8MP0008007_abnormal_cellular_replicative3.25504760
9MP0003806_abnormal_nucleotide_metabolis2.83218528
10MP0008932_abnormal_embryonic_tissue2.80817732
11MP0003786_premature_aging2.49284208
12MP0001730_embryonic_growth_arrest2.48722634
13MP0003123_paternal_imprinting2.38642333
14MP0002396_abnormal_hematopoietic_system2.33949890
15MP0003718_maternal_effect2.28254345
16MP0000350_abnormal_cell_proliferation2.22062772
17MP0005451_abnormal_body_composition2.22053860
18MP0004233_abnormal_muscle_weight2.15737379
19MP0004185_abnormal_adipocyte_glucose2.13067987
20MP0002877_abnormal_melanocyte_morpholog2.06935794
21MP0010352_gastrointestinal_tract_polyps2.01670409
22MP0008877_abnormal_DNA_methylation1.96138499
23MP0010307_abnormal_tumor_latency1.89910360
24MP0001661_extended_life_span1.82797293
25MP0005058_abnormal_lysosome_morphology1.77836876
26MP0000678_abnormal_parathyroid_gland1.76593958
27MP0001697_abnormal_embryo_size1.72102255
28MP0000490_abnormal_crypts_of1.69683185
29MP0005380_embryogenesis_phenotype1.69367295
30MP0001672_abnormal_embryogenesis/_devel1.69367295
31MP0000537_abnormal_urethra_morphology1.68539573
32MP0001849_ear_inflammation1.68309797
33MP0005076_abnormal_cell_differentiation1.67082631
34MP0002080_prenatal_lethality1.66943830
35MP0001346_abnormal_lacrimal_gland1.65210382
36MP0000313_abnormal_cell_death1.50405440
37MP0003984_embryonic_growth_retardation1.49664380
38MP0002019_abnormal_tumor_incidence1.48811284
39MP0009333_abnormal_splenocyte_physiolog1.47076604
40MP0003453_abnormal_keratinocyte_physiol1.45643828
41MP0002088_abnormal_embryonic_growth/wei1.45306771
42MP0002796_impaired_skin_barrier1.43317265
43MP0003186_abnormal_redox_activity1.36464951
44MP0002085_abnormal_embryonic_tissue1.31435045
45MP0003567_abnormal_fetal_cardiomyocyte1.29710478
46MP0000358_abnormal_cell_content/1.28973368
47MP0004808_abnormal_hematopoietic_stem1.28938590
48MP0002086_abnormal_extraembryonic_tissu1.24736616
49MP0005083_abnormal_biliary_tract1.20485163
50MP0002249_abnormal_larynx_morphology1.19548439
51MP0002132_abnormal_respiratory_system1.18804228
52MP0002084_abnormal_developmental_patter1.18519754
53MP0000003_abnormal_adipose_tissue1.15777141
54MP0004197_abnormal_fetal_growth/weight/1.14379612
55MP0003315_abnormal_perineum_morphology1.13927439
56MP0001764_abnormal_homeostasis1.12409420
57MP0002160_abnormal_reproductive_system1.12249610
58MP0006036_abnormal_mitochondrial_physio1.11204987
59MP0002210_abnormal_sex_determination1.09462546
60MP0001216_abnormal_epidermal_layer1.07364151
61MP0006035_abnormal_mitochondrial_morpho1.06459882
62MP0001545_abnormal_hematopoietic_system1.06458841
63MP0005397_hematopoietic_system_phenotyp1.06458841
64MP0001873_stomach_inflammation1.06241430
65MP0003763_abnormal_thymus_physiology1.05209573
66MP0010234_abnormal_vibrissa_follicle1.04653139
67MP0003121_genomic_imprinting1.03249891
68MP0002722_abnormal_immune_system1.03225726
69MP0001348_abnormal_lacrimal_gland1.02540942
70MP0000689_abnormal_spleen_morphology1.02135588
71MP0003890_abnormal_embryonic-extraembry1.01993447
72MP0002060_abnormal_skin_morphology1.01832945
73MP0001145_abnormal_male_reproductive0.99933939
74MP0008260_abnormal_autophagy0.98698827
75MP0002398_abnormal_bone_marrow0.98631428
76MP0004133_heterotaxia0.98432117
77MP0006292_abnormal_olfactory_placode0.98281260
78MP0000703_abnormal_thymus_morphology0.97181775
79MP0003221_abnormal_cardiomyocyte_apopto0.96097613
80MP0009840_abnormal_foam_cell0.95091710
81MP0005330_cardiomyopathy0.94222222
82MP0009672_abnormal_birth_weight0.92632227
83MP0001727_abnormal_embryo_implantation0.89945280
84MP0001853_heart_inflammation0.89698753
85MP0008789_abnormal_olfactory_epithelium0.89088367
86MP0010030_abnormal_orbit_morphology0.88894592
87MP0001881_abnormal_mammary_gland0.88635880
88MP0005384_cellular_phenotype0.88319594
89MP0005389_reproductive_system_phenotype0.87039756
90MP0000653_abnormal_sex_gland0.83900951
91MP0002429_abnormal_blood_cell0.83555355
92MP0003878_abnormal_ear_physiology0.83351832
93MP0005377_hearing/vestibular/ear_phenot0.83351832
94MP0001119_abnormal_female_reproductive0.83157946
95MP0001929_abnormal_gametogenesis0.82559267
96MP0002970_abnormal_white_adipose0.82536196
97MP0005666_abnormal_adipose_tissue0.82180242
98MP0000747_muscle_weakness0.81800983
99MP0000858_altered_metastatic_potential0.81751537
100MP0005023_abnormal_wound_healing0.81700446
101MP0009697_abnormal_copulation0.80189364
102MP0005171_absent_coat_pigmentation0.79527013
103MP0002653_abnormal_ependyma_morphology0.79465660
104MP0009379_abnormal_foot_pigmentation0.79250071
105MP0009931_abnormal_skin_appearance0.78945772
106MP0010771_integument_phenotype0.77886202
107MP0002098_abnormal_vibrissa_morphology0.76745740
108MP0005360_urolithiasis0.75492203
109MP0005075_abnormal_melanosome_morpholog0.75402872
110MP0005621_abnormal_cell_physiology0.74354951
111MP0000751_myopathy0.73128618
112MP0005266_abnormal_metabolism0.72871799
113MP0000627_abnormal_mammary_gland0.72436361
114MP0005670_abnormal_white_adipose0.72388517
115MP0000750_abnormal_muscle_regeneration0.70203601
116MP0004858_abnormal_nervous_system0.70172691
117MP0005499_abnormal_olfactory_system0.70147653
118MP0005394_taste/olfaction_phenotype0.70147653
119MP0004264_abnormal_extraembryonic_tissu0.69507172
120MP0000477_abnormal_intestine_morphology0.69209520
121MP0001293_anophthalmia0.69014273
122MP0005623_abnormal_meninges_morphology0.67938696
123MP0000762_abnormal_tongue_morphology0.66882041
124MP0009278_abnormal_bone_marrow0.66661738
125MP0005375_adipose_tissue_phenotype0.66022776
126MP0008875_abnormal_xenobiotic_pharmacok0.65522787
127MP0002111_abnormal_tail_morphology0.65268079
128MP0003941_abnormal_skin_development0.64424992
129MP0000598_abnormal_liver_morphology0.64103947
130MP0000716_abnormal_immune_system0.62947965
131MP0005395_other_phenotype0.62793934
132MP0001542_abnormal_bone_strength0.59024683
133MP0001915_intracranial_hemorrhage0.58745981
134MP0003705_abnormal_hypodermis_morpholog0.58582223
135MP0001919_abnormal_reproductive_system0.57727619
136MP0003119_abnormal_digestive_system0.57602015
137MP0000465_gastrointestinal_hemorrhage0.56591097
138MP0002269_muscular_atrophy0.56347665
139MP0005671_abnormal_response_to0.54039640
140MP0002095_abnormal_skin_pigmentation0.52344404
141MP0009053_abnormal_anal_canal0.51759322
142MP0001243_abnormal_dermal_layer0.49995105
143MP0004084_abnormal_cardiac_muscle0.49393973
144MP0003566_abnormal_cell_adhesion0.47930220
145MP0005501_abnormal_skin_physiology0.47453623

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.90769190
2Microvesicular hepatic steatosis (HP:0001414)4.15041558
3Oral leukoplakia (HP:0002745)3.88479959
4Abnormal number of erythroid precursors (HP:0012131)3.85937499
5Abnormality of cells of the erythroid lineage (HP:0012130)3.84432477
6Ragged-red muscle fibers (HP:0003200)3.79340007
7Reticulocytopenia (HP:0001896)3.78490400
8Breast hypoplasia (HP:0003187)3.77253495
9Selective tooth agenesis (HP:0001592)3.67981518
10Testicular atrophy (HP:0000029)3.62997308
11Carpal bone hypoplasia (HP:0001498)3.61104321
12Cerebral hypomyelination (HP:0006808)3.56156050
13Aplastic anemia (HP:0001915)3.55692975
14Rough bone trabeculation (HP:0100670)3.55246346
15Abnormality of the anterior horn cell (HP:0006802)3.52686222
16Degeneration of anterior horn cells (HP:0002398)3.52686222
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27189365
18Poikiloderma (HP:0001029)3.26788425
19Chromsome breakage (HP:0040012)3.24916746
20Medulloblastoma (HP:0002885)3.22983341
21Hyperacusis (HP:0010780)3.19721290
22Microretrognathia (HP:0000308)3.15156420
23Multiple enchondromatosis (HP:0005701)3.09474106
24Meckel diverticulum (HP:0002245)3.02772773
25Colon cancer (HP:0003003)3.01087340
26Abnormality of the preputium (HP:0100587)3.00579027
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00402607
28Patellar aplasia (HP:0006443)2.99685934
29Ependymoma (HP:0002888)2.97572577
30Agnosia (HP:0010524)2.87808753
31Abnormality of the ileum (HP:0001549)2.85468709
32Cholecystitis (HP:0001082)2.84990373
33Abnormal gallbladder physiology (HP:0012438)2.84990373
34Aplasia/Hypoplasia of the patella (HP:0006498)2.83757600
35Premature graying of hair (HP:0002216)2.75674619
36Bone marrow hypocellularity (HP:0005528)2.73182253
37Abnormality of chromosome stability (HP:0003220)2.69579671
38Trismus (HP:0000211)2.65743416
39Premature ovarian failure (HP:0008209)2.64884990
40Macrocytic anemia (HP:0001972)2.62780049
41Abnormality of pyrimidine metabolism (HP:0004353)2.62673036
42Neoplasm of the pancreas (HP:0002894)2.60941423
43Absent thumb (HP:0009777)2.60004179
44Impulsivity (HP:0100710)2.55313882
45Insomnia (HP:0100785)2.54587545
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.52218870
47Rhabdomyosarcoma (HP:0002859)2.51308443
48Abnormal trabecular bone morphology (HP:0100671)2.51305323
49Myelodysplasia (HP:0002863)2.50872733
50Secondary amenorrhea (HP:0000869)2.46613768
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.43463564
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43123819
53Abnormal protein N-linked glycosylation (HP:0012347)2.43123819
54Abnormal protein glycosylation (HP:0012346)2.43123819
55Abnormal glycosylation (HP:0012345)2.43123819
56Increased intramyocellular lipid droplets (HP:0012240)2.42051636
57Abnormality of the distal phalanges of the toes (HP:0010182)2.41748377
5811 pairs of ribs (HP:0000878)2.41610890
59Absent radius (HP:0003974)2.38030389
60Myopathic facies (HP:0002058)2.37892048
61Cellular immunodeficiency (HP:0005374)2.35455311
62Abnormal mitochondria in muscle tissue (HP:0008316)2.34722236
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33013562
64Type I transferrin isoform profile (HP:0003642)2.31674656
65Megaloblastic anemia (HP:0001889)2.28192437
66Small intestinal stenosis (HP:0012848)2.28169210
67Duodenal stenosis (HP:0100867)2.28169210
68Progressive external ophthalmoplegia (HP:0000590)2.24951344
69Thrombocytosis (HP:0001894)2.24875749
70Upper limb amyotrophy (HP:0009129)2.24293264
71Distal upper limb amyotrophy (HP:0007149)2.24293264
72Pallor (HP:0000980)2.24208843
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24195337
74CNS hypomyelination (HP:0003429)2.24035081
75Amaurosis fugax (HP:0100576)2.23248678
76Pancytopenia (HP:0001876)2.22182117
77Increased muscle lipid content (HP:0009058)2.21325413
78Reduced antithrombin III activity (HP:0001976)2.21104222
79Increased serum lactate (HP:0002151)2.19430445
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.18667151
81Hypertensive crisis (HP:0100735)2.17331213
82Proximal placement of thumb (HP:0009623)2.17192233
83Sloping forehead (HP:0000340)2.15927304
84Aplasia involving forearm bones (HP:0009822)2.15913855
85Absent forearm bone (HP:0003953)2.15913855
86Ulnar bowing (HP:0003031)2.14029761
87Broad distal phalanx of finger (HP:0009836)2.13392311
88Sparse eyelashes (HP:0000653)2.13205723
89Cleft eyelid (HP:0000625)2.12452128
90Horseshoe kidney (HP:0000085)2.11482531
91Progressive muscle weakness (HP:0003323)2.10516419
92Deviation of the thumb (HP:0009603)2.08811615
93Abnormalities of placenta or umbilical cord (HP:0001194)2.08356413
94Vertebral compression fractures (HP:0002953)2.08328350
95Basal cell carcinoma (HP:0002671)2.07326673
96Lymphoma (HP:0002665)2.05954867
97Truncus arteriosus (HP:0001660)2.05864548
98Exercise intolerance (HP:0003546)2.04526124
99Tracheoesophageal fistula (HP:0002575)2.03624895
100Hand muscle atrophy (HP:0009130)2.02549305
101Hypokinesia (HP:0002375)1.94867756
102Abnormality of the labia minora (HP:0012880)1.94827469
103Postnatal microcephaly (HP:0005484)1.93911996
104Abnormality of alanine metabolism (HP:0010916)1.91274430
105Hyperalaninemia (HP:0003348)1.91274430
106Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91274430
107Hypoplasia of the pons (HP:0012110)1.90661332
108Abnormality of the duodenum (HP:0002246)1.89868796
109Abnormality of DNA repair (HP:0003254)1.89523339
110Lactic acidosis (HP:0003128)1.89376227
111Overriding aorta (HP:0002623)1.89349181
112Increased nuchal translucency (HP:0010880)1.88769430
113Glioma (HP:0009733)1.88207899
114Glossoptosis (HP:0000162)1.88180968
115Seborrheic dermatitis (HP:0001051)1.86023035
116Abnormality of the umbilical cord (HP:0010881)1.85977192
117Achilles tendon contracture (HP:0001771)1.85552654
118Squamous cell carcinoma (HP:0002860)1.84151829
119IgM deficiency (HP:0002850)1.84021472
120Abnormal lung lobation (HP:0002101)1.82926947
121Septate vagina (HP:0001153)1.82699532
122Cholelithiasis (HP:0001081)1.82531514
123Gout (HP:0001997)1.81389994
124Abnormality of glycolysis (HP:0004366)1.81306560
125Increased serum pyruvate (HP:0003542)1.81306560
126Abnormality of the calcaneus (HP:0008364)1.80401808
127Ureteral duplication (HP:0000073)1.79598089
128Entropion (HP:0000621)1.78976789
129Freckling (HP:0001480)1.78024035
130Absent epiphyses (HP:0010577)1.77679175
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77679175
132Increased hepatocellular lipid droplets (HP:0006565)1.77591457
133Single umbilical artery (HP:0001195)1.77189782
134Abnormality of the fetal cardiovascular system (HP:0010948)1.77189782
135Abnormal umbilical cord blood vessels (HP:0011403)1.77189782
136Acute encephalopathy (HP:0006846)1.76825237
137Reduced subcutaneous adipose tissue (HP:0003758)1.76689369
138Neoplasm of the colon (HP:0100273)1.76066434
139Elfin facies (HP:0004428)1.75892674
140Opisthotonus (HP:0002179)1.75276856
141Mitochondrial inheritance (HP:0001427)1.75219739
142Increased CSF lactate (HP:0002490)1.74809653
143Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74550835
144Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74550835
145Supernumerary spleens (HP:0009799)1.74329559
146Vaginal fistula (HP:0004320)1.74275158
147Cutaneous melanoma (HP:0012056)1.74141237
148Triphalangeal thumb (HP:0001199)1.73705100
149Hepatocellular necrosis (HP:0001404)1.73136514
150Cafe-au-lait spot (HP:0000957)1.73125518
151Hepatic necrosis (HP:0002605)1.72689460
152Spinal muscular atrophy (HP:0007269)1.72295797
153Tongue fasciculations (HP:0001308)1.72236715
154Abnormality of reticulocytes (HP:0004312)1.71828132
155Acute necrotizing encephalopathy (HP:0006965)1.71823343
156Muscle fiber atrophy (HP:0100295)1.71387653
157Self-mutilation (HP:0000742)1.70897674
158Hypoparathyroidism (HP:0000829)1.70844081
159Duplicated collecting system (HP:0000081)1.70127828
160Short nail (HP:0001799)1.69266240
161Abnormality of the tricuspid valve (HP:0001702)1.67964774
162Spastic paraparesis (HP:0002313)1.64127475
163Hypergonadotropic hypogonadism (HP:0000815)1.62403565
164Hyperthyroidism (HP:0000836)1.62053145
165Patellar dislocation (HP:0002999)1.61976837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.16846382
2WEE14.57053349
3EIF2AK13.60877492
4SMG13.33847415
5TSSK63.30195781
6STK163.16909728
7CDC73.09841241
8NEK12.90604036
9SRPK12.74859767
10VRK22.65621258
11MST1R2.49938112
12EIF2AK32.25214094
13NEK22.05481819
14TTK2.03157105
15NME22.00600348
16BRSK21.99487326
17PLK41.97084533
18PLK11.91129890
19MKNK11.90594630
20TESK21.89995683
21PASK1.81380247
22MKNK21.75282048
23ICK1.73061848
24EPHA21.71059649
25ACVR1B1.70262902
26PLK31.56320830
27CDK71.54892001
28TLK11.53295118
29RPS6KB21.52693798
30BRSK11.52128815
31ATR1.49011631
32VRK11.47744627
33SCYL21.46344199
34AURKB1.45366158
35CCNB11.40846615
36AURKA1.39701902
37ZAK1.35891669
38CHEK21.35621396
39MAP3K81.30478607
40SIK11.27947036
41ERN11.26495796
42PRPF4B1.23317138
43CDK41.22530109
44MAP3K111.21161730
45BCKDK1.20657207
46TGFBR11.19582483
47PIM21.17090111
48DYRK31.09458219
49EEF2K1.06994412
50MET1.04282427
51CHEK11.04099192
52TESK11.00590930
53RPS6KA41.00362135
54KDR1.00046864
55STK100.98769894
56FLT30.95796565
57DAPK10.95438123
58PAK40.95317369
59MAP4K10.89536214
60MAPK110.85411532
61MAP2K30.81754380
62PDK40.80024931
63PDK30.80024931
64STK40.79010061
65TAOK20.77733387
66NME10.77672167
67ABL20.76657942
68PAK10.76523713
69BRAF0.76154822
70CDK90.75490368
71CSNK2A20.70852258
72PIM10.70698094
73ALK0.70301957
74CDK20.69804155
75CSNK2A10.68918511
76CDK80.67591578
77PRKCI0.67539048
78PTK20.64451122
79ATM0.60778662
80EIF2AK20.60380791
81LRRK20.59716986
82MAP3K120.59061487
83PKN20.56254864
84AKT30.55604457
85MAPKAPK30.55526934
86CSNK1G30.55116607
87CLK10.54474732
88RAF10.52815182
89ERBB40.51722210
90MAP3K30.49034938
91CDK10.48897274
92PIK3CG0.48466682
93KSR20.47593770
94ZAP700.46610364
95CDK11A0.46302787
96BRD40.46153263
97CSNK1A1L0.45131569
98FGFR40.42832489
99MUSK0.42694126
100BMX0.40653992
101SIK30.40580346
102TRIB30.40549253
103MAP3K100.40320056
104DAPK30.39364722
105CDK60.39098622
106CDK150.39037277
107CDK140.38118890
108IRAK40.37175963
109CDK180.35509191
110CDK120.33510511
111LMTK20.32093752
112TBK10.31660528
113NTRK10.31403004
114STK38L0.30806409
115MAP3K10.30801925
116CSNK1E0.30251173
117PNCK0.30208802
118PBK0.29483087
119PDK20.28956052
120IRAK30.28791420
121LIMK10.27325015
122KIT0.26851693
123AKT20.26545184
124RPS6KA50.26135480
125ILK0.24209710
126LATS20.22923287
127BTK0.22055526
128GRK60.20912915
129PRKDC0.18469303
130JAK30.18356571
131MTOR0.17933839
132DYRK20.17852318
133ARAF0.16108361

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85084120
2Mismatch repair_Homo sapiens_hsa034304.19487875
3Proteasome_Homo sapiens_hsa030504.04330175
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80491512
5RNA polymerase_Homo sapiens_hsa030203.37898986
6Ribosome_Homo sapiens_hsa030103.16580969
7Spliceosome_Homo sapiens_hsa030403.08101714
8RNA transport_Homo sapiens_hsa030133.04074161
9Base excision repair_Homo sapiens_hsa034102.93387265
10Nucleotide excision repair_Homo sapiens_hsa034202.87186190
11One carbon pool by folate_Homo sapiens_hsa006702.82002609
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74728422
13Homologous recombination_Homo sapiens_hsa034402.68277268
14Pyrimidine metabolism_Homo sapiens_hsa002402.58895300
15Cell cycle_Homo sapiens_hsa041102.28374664
16Fanconi anemia pathway_Homo sapiens_hsa034601.89425709
17Non-homologous end-joining_Homo sapiens_hsa034501.71859138
18RNA degradation_Homo sapiens_hsa030181.61038864
19Other glycan degradation_Homo sapiens_hsa005111.56110548
20Basal transcription factors_Homo sapiens_hsa030221.54960560
21Biosynthesis of amino acids_Homo sapiens_hsa012301.45802673
22Vitamin B6 metabolism_Homo sapiens_hsa007501.41883871
23p53 signaling pathway_Homo sapiens_hsa041151.37358926
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.36198124
25Purine metabolism_Homo sapiens_hsa002301.36144319
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32378327
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.32102147
28Selenocompound metabolism_Homo sapiens_hsa004501.29426526
29Pentose phosphate pathway_Homo sapiens_hsa000301.29008054
30mRNA surveillance pathway_Homo sapiens_hsa030151.26410435
31Folate biosynthesis_Homo sapiens_hsa007901.22242373
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22204779
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.20919989
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20354807
35Epstein-Barr virus infection_Homo sapiens_hsa051691.15479258
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10752511
37Fatty acid elongation_Homo sapiens_hsa000621.08460101
38Carbon metabolism_Homo sapiens_hsa012001.03391140
39Sulfur relay system_Homo sapiens_hsa041220.99988599
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97491404
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86879582
42Fructose and mannose metabolism_Homo sapiens_hsa000510.86173959
43Systemic lupus erythematosus_Homo sapiens_hsa053220.83870281
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.83587180
45Protein export_Homo sapiens_hsa030600.80097835
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77503225
47Antigen processing and presentation_Homo sapiens_hsa046120.75877248
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75141077
49Arginine biosynthesis_Homo sapiens_hsa002200.73819235
50Vibrio cholerae infection_Homo sapiens_hsa051100.73697299
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73629894
52Viral carcinogenesis_Homo sapiens_hsa052030.71747707
53Glutathione metabolism_Homo sapiens_hsa004800.69892263
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68952086
55Oocyte meiosis_Homo sapiens_hsa041140.68858160
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68647480
57Galactose metabolism_Homo sapiens_hsa000520.66339759
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66131571
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65907901
60Chronic myeloid leukemia_Homo sapiens_hsa052200.64720094
61Legionellosis_Homo sapiens_hsa051340.64239688
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63618423
63Herpes simplex infection_Homo sapiens_hsa051680.60137875
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51864050
65Huntingtons disease_Homo sapiens_hsa050160.49382743
66HTLV-I infection_Homo sapiens_hsa051660.48816740
67Sulfur metabolism_Homo sapiens_hsa009200.48575348
68Pancreatic cancer_Homo sapiens_hsa052120.47921252
69Regulation of autophagy_Homo sapiens_hsa041400.44308583
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44185850
71Non-small cell lung cancer_Homo sapiens_hsa052230.43878872
72N-Glycan biosynthesis_Homo sapiens_hsa005100.42582739
73Lysine degradation_Homo sapiens_hsa003100.42483340
74Parkinsons disease_Homo sapiens_hsa050120.39332539
75Metabolic pathways_Homo sapiens_hsa011000.39289189
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36829548
77Sphingolipid metabolism_Homo sapiens_hsa006000.36148240
78Thyroid cancer_Homo sapiens_hsa052160.34491558
79Pyruvate metabolism_Homo sapiens_hsa006200.34482063
80Arginine and proline metabolism_Homo sapiens_hsa003300.32779809
81Alzheimers disease_Homo sapiens_hsa050100.32278879
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30826111
83Primary immunodeficiency_Homo sapiens_hsa053400.30403154
84Apoptosis_Homo sapiens_hsa042100.28969037
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28771454
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28603880
87Notch signaling pathway_Homo sapiens_hsa043300.27324015
88Lysosome_Homo sapiens_hsa041420.24359161
89Prion diseases_Homo sapiens_hsa050200.23633055
90Tyrosine metabolism_Homo sapiens_hsa003500.23016614
91Shigellosis_Homo sapiens_hsa051310.22616541
92HIF-1 signaling pathway_Homo sapiens_hsa040660.22022711
93Fatty acid metabolism_Homo sapiens_hsa012120.20590422
94Measles_Homo sapiens_hsa051620.20405929
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20241008
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.19525739
97Oxidative phosphorylation_Homo sapiens_hsa001900.19370145
98Steroid biosynthesis_Homo sapiens_hsa001000.18727293
99Small cell lung cancer_Homo sapiens_hsa052220.18076071
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18036110
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15659080
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12379709
103Influenza A_Homo sapiens_hsa051640.10877885
104MicroRNAs in cancer_Homo sapiens_hsa052060.10467582
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09060706
106Vitamin digestion and absorption_Homo sapiens_hsa049770.09059333
107Alcoholism_Homo sapiens_hsa050340.08955432
108Hepatitis B_Homo sapiens_hsa051610.08846898
109Type I diabetes mellitus_Homo sapiens_hsa049400.08614870
110Acute myeloid leukemia_Homo sapiens_hsa052210.07986302
111Renin-angiotensin system_Homo sapiens_hsa046140.07177326
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06212305
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.06150654
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05998879
115Bladder cancer_Homo sapiens_hsa052190.05576938
116Arachidonic acid metabolism_Homo sapiens_hsa005900.04617377
117Phenylalanine metabolism_Homo sapiens_hsa003600.03245431
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.02975663
119Hippo signaling pathway_Homo sapiens_hsa043900.02899590
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02550389
121Colorectal cancer_Homo sapiens_hsa052100.00022134
122beta-Alanine metabolism_Homo sapiens_hsa00410-0.0027556
123Allograft rejection_Homo sapiens_hsa05330-0.0002218

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