DDX54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)4.73209218
2translational termination (GO:0006415)4.51198108
3maturation of SSU-rRNA (GO:0030490)4.48875630
4ribosomal small subunit assembly (GO:0000028)4.42094262
5DNA unwinding involved in DNA replication (GO:0006268)4.32693409
6proline biosynthetic process (GO:0006561)4.18833981
7folic acid-containing compound biosynthetic process (GO:0009396)4.14354560
8translational elongation (GO:0006414)4.11542963
9protein localization to kinetochore (GO:0034501)4.07200169
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.07172088
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.90830366
12ribosomal small subunit biogenesis (GO:0042274)3.90559482
13translational initiation (GO:0006413)3.87205023
14formation of translation preinitiation complex (GO:0001731)3.80168499
15protein localization to chromosome, centromeric region (GO:0071459)3.62854350
16DNA strand elongation involved in DNA replication (GO:0006271)3.62418597
17apoptotic process involved in morphogenesis (GO:0060561)3.57365316
18mitotic nuclear envelope disassembly (GO:0007077)3.56323125
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.54432674
20histone arginine methylation (GO:0034969)3.53963441
21Golgi transport vesicle coating (GO:0048200)3.51768888
22COPI coating of Golgi vesicle (GO:0048205)3.51768888
23viral life cycle (GO:0019058)3.51535491
24cellular protein complex disassembly (GO:0043624)3.49175321
25DNA replication initiation (GO:0006270)3.44657610
26protein targeting to ER (GO:0045047)3.43838553
27DNA strand elongation (GO:0022616)3.42126928
28cotranslational protein targeting to membrane (GO:0006613)3.39312481
29nuclear pore organization (GO:0006999)3.38166721
30ribosomal large subunit biogenesis (GO:0042273)3.35057562
31regulation of translational fidelity (GO:0006450)3.34430617
32peptidyl-arginine N-methylation (GO:0035246)3.33645439
33peptidyl-arginine methylation (GO:0018216)3.33645439
34IMP biosynthetic process (GO:0006188)3.32934962
35nuclear pore complex assembly (GO:0051292)3.32544145
36ribonucleoprotein complex biogenesis (GO:0022613)3.31049329
37nuclear envelope disassembly (GO:0051081)3.30648319
38membrane disassembly (GO:0030397)3.30648319
39protein complex disassembly (GO:0043241)3.28500367
40rRNA transcription (GO:0009303)3.28370202
41establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26229515
42nucleobase biosynthetic process (GO:0046112)3.21832426
43protein complex localization (GO:0031503)3.20379830
44regulation of histone H3-K9 methylation (GO:0051570)3.19185933
45telomere maintenance via semi-conservative replication (GO:0032201)3.19173858
46DNA replication-dependent nucleosome assembly (GO:0006335)3.17384675
47DNA replication-dependent nucleosome organization (GO:0034723)3.17384675
48heterochromatin organization (GO:0070828)3.16732013
49ribosome biogenesis (GO:0042254)3.16642535
50protein localization to endoplasmic reticulum (GO:0070972)3.16369981
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.13485389
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11032554
53glucose catabolic process (GO:0006007)3.10940230
54DNA duplex unwinding (GO:0032508)3.10785911
55NADPH regeneration (GO:0006740)3.08076017
56DNA geometric change (GO:0032392)3.07889581
57protein-DNA complex disassembly (GO:0032986)3.04892969
58nucleosome disassembly (GO:0006337)3.04892969
59nucleobase-containing small molecule interconversion (GO:0015949)3.04067477
60macromolecular complex disassembly (GO:0032984)3.03232648
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.01927562
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.01927562
63negative regulation of histone methylation (GO:0031061)2.98107667
64pentose metabolic process (GO:0019321)2.97851631
65nuclear-transcribed mRNA catabolic process (GO:0000956)2.96685405
66regulation of translational termination (GO:0006449)2.96683877
67negative regulation of RNA splicing (GO:0033119)2.96124025
68negative regulation of erythrocyte differentiation (GO:0045647)2.95179692
69protein maturation by protein folding (GO:0022417)2.93680928
70mitotic nuclear envelope reassembly (GO:0007084)2.92833204
71nuclear envelope reassembly (GO:0031468)2.92833204
72cellular protein complex localization (GO:0034629)2.92485524
73ncRNA 3-end processing (GO:0043628)2.92037977
74negative regulation of cell size (GO:0045792)2.91833522
75IMP metabolic process (GO:0046040)2.91640531
76T cell apoptotic process (GO:0070231)2.90504472
77ribosome assembly (GO:0042255)2.89878644
783-UTR-mediated mRNA stabilization (GO:0070935)2.89747698
79pre-miRNA processing (GO:0031054)2.88379997
80RNA catabolic process (GO:0006401)2.87872708
81regulation of gene silencing by RNA (GO:0060966)2.87727805
82regulation of posttranscriptional gene silencing (GO:0060147)2.87727805
83regulation of gene silencing by miRNA (GO:0060964)2.87727805
84mitotic G1 DNA damage checkpoint (GO:0031571)2.87338872
85deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86898347
86mitotic metaphase plate congression (GO:0007080)2.86514429
87mRNA catabolic process (GO:0006402)2.84226259
88morphogenesis of an endothelium (GO:0003159)2.84144403
89endothelial tube morphogenesis (GO:0061154)2.84144403
90response to UV-C (GO:0010225)2.83941202
91antigen processing and presentation of endogenous antigen (GO:0019883)2.83555779
92focal adhesion assembly (GO:0048041)2.82714267
93cell-substrate adherens junction assembly (GO:0007045)2.82714267
94telomere maintenance via recombination (GO:0000722)2.81628183
95positive regulation of gamma-delta T cell activation (GO:0046645)2.81337523
96activation of Rac GTPase activity (GO:0032863)2.80353007
97regulation of gamma-delta T cell differentiation (GO:0045586)2.78163114
98rRNA processing (GO:0006364)2.77944492
99DNA topological change (GO:0006265)2.77850996
100positive regulation of chromosome segregation (GO:0051984)2.77831287
101adherens junction assembly (GO:0034333)2.77013867
102folic acid metabolic process (GO:0046655)2.76101136
103negative regulation of mRNA metabolic process (GO:1903312)2.75675079
104chromosome condensation (GO:0030261)2.74816735
105mitotic recombination (GO:0006312)2.74617961
106pinocytosis (GO:0006907)2.74547736
107regulation of spindle organization (GO:0090224)2.72725008
108mitotic sister chromatid segregation (GO:0000070)2.71853425
109rRNA metabolic process (GO:0016072)2.71453740
110proline metabolic process (GO:0006560)2.71351102
111nuclear envelope organization (GO:0006998)2.71116232
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70248464
113protein retention in ER lumen (GO:0006621)2.70008203
114purine nucleobase biosynthetic process (GO:0009113)2.69570509
115chromatin assembly (GO:0031497)2.68642403
116mitochondrial fusion (GO:0008053)2.68169448
117establishment of integrated proviral latency (GO:0075713)2.65955930
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65680841
119sister chromatid segregation (GO:0000819)2.64106042
120DNA deamination (GO:0045006)2.64016413
121dosage compensation (GO:0007549)2.63997776
122regulation of chromatin binding (GO:0035561)2.62983142
123maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.62930555
124protein localization to chromosome (GO:0034502)2.62747590
125GDP-mannose metabolic process (GO:0019673)2.62581715
126mitotic G1/S transition checkpoint (GO:0044819)2.60881329
127L-serine metabolic process (GO:0006563)2.60869766
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60843570
129protein localization to endosome (GO:0036010)2.59255334
130maternal placenta development (GO:0001893)2.59148700
131positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58935477
132mRNA stabilization (GO:0048255)2.58753323
133RNA stabilization (GO:0043489)2.58753323
134regulation of RNA export from nucleus (GO:0046831)2.58405898
135regulation of protein heterodimerization activity (GO:0043497)2.57403040
136negative regulation of mRNA processing (GO:0050686)2.57236502
137DNA replication checkpoint (GO:0000076)2.55274340
138telomere maintenance via telomere lengthening (GO:0010833)2.54798745
139regulation of mitotic spindle organization (GO:0060236)2.54584403
140mitotic chromosome condensation (GO:0007076)2.54487622
141regulation of glucose import in response to insulin stimulus (GO:2001273)2.54447134
142pore complex assembly (GO:0046931)2.54251096
143peptidyl-arginine omega-N-methylation (GO:0035247)2.53880066
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.51730082
145DNA conformation change (GO:0071103)2.51517824
146G1 DNA damage checkpoint (GO:0044783)2.51415699
147translesion synthesis (GO:0019985)2.51148886
148mRNA splicing, via spliceosome (GO:0000398)2.50658495
149RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.50658495
150RNA splicing, via transesterification reactions (GO:0000375)2.48922011
151pentose-phosphate shunt (GO:0006098)2.48124469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85378646
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.49764333
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39003279
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.37770892
5MYC_22102868_ChIP-Seq_BL_Human3.05260170
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.80244094
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64502214
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45851620
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32855776
10VDR_21846776_ChIP-Seq_THP-1_Human2.21596385
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12238911
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07537869
13XRN2_22483619_ChIP-Seq_HELA_Human1.97937975
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89577821
15ETS1_20019798_ChIP-Seq_JURKAT_Human1.83965350
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78110275
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71787565
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68082047
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.67692224
20CIITA_25753668_ChIP-Seq_RAJI_Human1.67275938
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65858092
22* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64736997
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59283389
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.57507795
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57393416
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.57173864
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56938415
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53704807
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52064839
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49948907
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.49049379
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47351734
33VDR_23849224_ChIP-Seq_CD4+_Human1.46369728
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.45619704
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45402778
36TCF7_22412390_ChIP-Seq_EML_Mouse1.44610836
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44451339
38UTX_26944678_Chip-Seq_JUKART_Human1.44449968
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44307822
40* E2F1_21310950_ChIP-Seq_MCF-7_Human1.43551105
41MAF_26560356_Chip-Seq_TH1_Human1.41729619
42* FOXP3_21729870_ChIP-Seq_TREG_Human1.38686357
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37952221
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36940024
45GABP_19822575_ChIP-Seq_HepG2_Human1.36622492
46AR_21909140_ChIP-Seq_LNCAP_Human1.35175676
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.34801056
48KDM5A_27292631_Chip-Seq_BREAST_Human1.33975308
49P68_20966046_ChIP-Seq_HELA_Human1.32759908
50* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31955937
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31782566
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31016925
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30001023
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29366387
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28013291
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27462948
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27089732
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26973385
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26966590
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26494396
61* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26349574
62* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25457913
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25025819
64KDM2B_26808549_Chip-Seq_DND41_Human1.24572742
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22003500
66* TTF2_22483619_ChIP-Seq_HELA_Human1.21253592
67DCP1A_22483619_ChIP-Seq_HELA_Human1.20692952
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18391010
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17937024
70MYB_26560356_Chip-Seq_TH1_Human1.16855708
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.15736480
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14840678
73* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14264803
74ZNF263_19887448_ChIP-Seq_K562_Human1.14199864
75MAF_26560356_Chip-Seq_TH2_Human1.13198051
76SPI1_23547873_ChIP-Seq_NB4_Human1.12864694
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12343143
78* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12314271
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11930609
80MYB_26560356_Chip-Seq_TH2_Human1.11919919
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11836845
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11321815
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11128574
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.10694079
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10410505
86TFEB_21752829_ChIP-Seq_HELA_Human1.10352169
87IRF8_22096565_ChIP-ChIP_GC-B_Human1.10230053
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10063539
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09673575
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09646502
91VDR_24763502_ChIP-Seq_THP-1_Human1.08662228
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.07228199
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06818362
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.06363846
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.06333818
96ATF3_27146783_Chip-Seq_COLON_Human1.05750653
97* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05664690
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05454904
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03838037
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03748481
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03453708
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.02933226
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02346050
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01388202
105KDM2B_26808549_Chip-Seq_K562_Human1.00749445
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00334471
107IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00296200
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00187082
109NCOR1_26117541_ChIP-Seq_K562_Human1.00022825
110* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99715765
111SMC4_20622854_ChIP-Seq_HELA_Human0.99318052
112P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97863925
113TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97850988
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97347067
115* CREB1_26743006_Chip-Seq_LNCaP_Human0.96922780
116KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96303391
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95931282
118* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95808157
119SCL_19346495_ChIP-Seq_HPC-7_Human0.94978436
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94085803
121LXR_22292898_ChIP-Seq_THP-1_Human0.94024944
122RACK7_27058665_Chip-Seq_MCF-7_Human0.93617350
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93189969
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92824974
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92123289
126* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91529901
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90876936
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90073397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.48206963
2MP0005451_abnormal_body_composition3.47202600
3MP0004957_abnormal_blastocyst_morpholog3.03668298
4MP0003111_abnormal_nucleus_morphology2.93310954
5MP0003077_abnormal_cell_cycle2.88164574
6MP0010352_gastrointestinal_tract_polyps2.81978428
7MP0010094_abnormal_chromosome_stability2.69446448
8MP0008057_abnormal_DNA_replication2.31865402
9MP0002396_abnormal_hematopoietic_system2.20785317
10MP0003705_abnormal_hypodermis_morpholog2.20128657
11MP0000678_abnormal_parathyroid_gland2.09488180
12MP0004233_abnormal_muscle_weight2.06687832
13MP0003763_abnormal_thymus_physiology2.05943008
14MP0001730_embryonic_growth_arrest2.04070234
15MP0005058_abnormal_lysosome_morphology2.04001354
16MP0002796_impaired_skin_barrier2.00311031
17MP0009333_abnormal_splenocyte_physiolog1.90918641
18MP0008260_abnormal_autophagy1.88177198
19MP0000350_abnormal_cell_proliferation1.88119713
20MP0008007_abnormal_cellular_replicative1.85933815
21MP0000490_abnormal_crypts_of1.84550804
22MP0010307_abnormal_tumor_latency1.83128257
23MP0009278_abnormal_bone_marrow1.81939912
24MP0003303_peritoneal_inflammation1.81923690
25MP0000685_abnormal_immune_system1.81860516
26MP0005076_abnormal_cell_differentiation1.80937452
27MP0004808_abnormal_hematopoietic_stem1.78508118
28MP0002398_abnormal_bone_marrow1.72035614
29MP0001800_abnormal_humoral_immune1.71684380
30MP0010030_abnormal_orbit_morphology1.71400621
31MP0003300_gastrointestinal_ulcer1.69026318
32MP0009840_abnormal_foam_cell1.61844036
33MP0008058_abnormal_DNA_repair1.60522010
34MP0004858_abnormal_nervous_system1.59392904
35MP0005397_hematopoietic_system_phenotyp1.56307566
36MP0001545_abnormal_hematopoietic_system1.56307566
37MP0001835_abnormal_antigen_presentation1.53413564
38MP0002722_abnormal_immune_system1.52669512
39MP0003566_abnormal_cell_adhesion1.52627373
40MP0000703_abnormal_thymus_morphology1.52317585
41MP0002019_abnormal_tumor_incidence1.51721997
42MP0000689_abnormal_spleen_morphology1.50860400
43MP0005380_embryogenesis_phenotype1.50619829
44MP0001672_abnormal_embryogenesis/_devel1.50619829
45MP0000858_altered_metastatic_potential1.50288877
46MP0002249_abnormal_larynx_morphology1.48884160
47MP0003984_embryonic_growth_retardation1.42509941
48MP0002080_prenatal_lethality1.41162773
49MP0002088_abnormal_embryonic_growth/wei1.40732381
50MP0001697_abnormal_embryo_size1.40716516
51MP0005023_abnormal_wound_healing1.39616117
52MP0002452_abnormal_antigen_presenting1.38718566
53MP0008932_abnormal_embryonic_tissue1.38508000
54MP0005666_abnormal_adipose_tissue1.37278496
55MP0000716_abnormal_immune_system1.34023880
56MP0003436_decreased_susceptibility_to1.33234661
57MP0002086_abnormal_extraembryonic_tissu1.32973836
58MP0002429_abnormal_blood_cell1.32137956
59MP0004197_abnormal_fetal_growth/weight/1.31289561
60MP0010155_abnormal_intestine_physiology1.29944686
61MP0002420_abnormal_adaptive_immunity1.25993511
62MP0001873_stomach_inflammation1.25791304
63MP0006054_spinal_hemorrhage1.25085090
64MP0001819_abnormal_immune_cell1.24075275
65MP0002723_abnormal_immune_serum1.23912599
66MP0002085_abnormal_embryonic_tissue1.23507456
67MP0000313_abnormal_cell_death1.23210691
68MP0002405_respiratory_system_inflammati1.22891567
69MP0000003_abnormal_adipose_tissue1.22481791
70MP0002084_abnormal_developmental_patter1.22368246
71MP0005387_immune_system_phenotype1.21496930
72MP0001790_abnormal_immune_system1.21496930
73MP0002166_altered_tumor_susceptibility1.20085783
74MP0005623_abnormal_meninges_morphology1.19691895
75MP0004947_skin_inflammation1.18798782
76MP0005375_adipose_tissue_phenotype1.18681026
77MP0001849_ear_inflammation1.16662188
78MP0010234_abnormal_vibrissa_follicle1.15496160
79MP0005000_abnormal_immune_tolerance1.11851997
80MP0001661_extended_life_span1.11816836
81MP0002089_abnormal_postnatal_growth/wei1.05529429
82MP0005025_abnormal_response_to1.02920586
83MP0009379_abnormal_foot_pigmentation1.01675523
84MP0005671_abnormal_response_to1.00897953
85MP0000477_abnormal_intestine_morphology1.00884577
86MP0002060_abnormal_skin_morphology0.99579100
87MP0003315_abnormal_perineum_morphology0.99525281
88MP0003567_abnormal_fetal_cardiomyocyte0.98967971
89MP0005501_abnormal_skin_physiology0.98480668
90MP0000733_abnormal_muscle_development0.98075211
91MP0003448_altered_tumor_morphology0.95852466
92MP0001915_intracranial_hemorrhage0.94409560
93MP0003123_paternal_imprinting0.94390494
94MP0002006_tumorigenesis0.94236963
95MP0003866_abnormal_defecation0.94082420
96MP0000537_abnormal_urethra_morphology0.93166196
97MP0004264_abnormal_extraembryonic_tissu0.92760085
98MP0003453_abnormal_keratinocyte_physiol0.88906111
99MP0003806_abnormal_nucleotide_metabolis0.88763938
100MP0005464_abnormal_platelet_physiology0.88719162
101MP0000747_muscle_weakness0.88649655
102MP0001881_abnormal_mammary_gland0.88151549
103MP0003786_premature_aging0.87195479
104MP0000759_abnormal_skeletal_muscle0.86489950
105MP0010630_abnormal_cardiac_muscle0.85710910
106MP0002653_abnormal_ependyma_morphology0.85531665
107MP0001853_heart_inflammation0.85331075
108MP0003091_abnormal_cell_migration0.84575849
109MP0005621_abnormal_cell_physiology0.83161282
110MP0002877_abnormal_melanocyte_morpholog0.81526644
111MP0000465_gastrointestinal_hemorrhage0.81510108
112MP0009785_altered_susceptibility_to0.81210091
113MP0001346_abnormal_lacrimal_gland0.79781752
114MP0005257_abnormal_intraocular_pressure0.79579366
115MP0001845_abnormal_inflammatory_respons0.78593685
116MP0005330_cardiomyopathy0.78213506
117MP0003191_abnormal_cellular_cholesterol0.78050483
118MP0000358_abnormal_cell_content/0.77425727
119MP0004185_abnormal_adipocyte_glucose0.74816864
120MP0002098_abnormal_vibrissa_morphology0.74474092
121MP0004087_abnormal_muscle_fiber0.73810437
122MP0001216_abnormal_epidermal_layer0.72376186
123MP0008770_decreased_survivor_rate0.71812581
124MP0003119_abnormal_digestive_system0.71503513
125MP0000681_abnormal_thyroid_gland0.71448530
126MP0000751_myopathy0.71442535
127MP0000377_abnormal_hair_follicle0.70748004
128MP0000762_abnormal_tongue_morphology0.70479297
129MP0002254_reproductive_system_inflammat0.70337986
130MP0009931_abnormal_skin_appearance0.70060787
131MP0000467_abnormal_esophagus_morphology0.69879885
132MP0001348_abnormal_lacrimal_gland0.69814954
133MP0009672_abnormal_birth_weight0.69714332
134MP0005384_cellular_phenotype0.68309794
135MP0000598_abnormal_liver_morphology0.67893665
136MP0000750_abnormal_muscle_regeneration0.67343203

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.10819190
2Abnormality of cells of the erythroid lineage (HP:0012130)3.34081927
3Ependymoma (HP:0002888)3.30503939
4Abnormal number of erythroid precursors (HP:0012131)3.05966555
5Thrombocytosis (HP:0001894)3.02226886
6Achilles tendon contracture (HP:0001771)3.00952626
7Selective tooth agenesis (HP:0001592)2.95484813
8Ragged-red muscle fibers (HP:0003200)2.87914749
9Rectal prolapse (HP:0002035)2.84028775
10Cellulitis (HP:0100658)2.82113047
11Distal lower limb amyotrophy (HP:0008944)2.80470139
12Basal cell carcinoma (HP:0002671)2.77433892
13Centrally nucleated skeletal muscle fibers (HP:0003687)2.71704450
14Recurrent bronchitis (HP:0002837)2.64464863
15Abnormality of the Achilles tendon (HP:0005109)2.62006117
16IgM deficiency (HP:0002850)2.60273564
17Broad face (HP:0000283)2.57245312
18Broad distal phalanx of finger (HP:0009836)2.56092918
19Vertebral compression fractures (HP:0002953)2.54905310
20Trismus (HP:0000211)2.54710060
21Increased connective tissue (HP:0009025)2.54197006
22Pustule (HP:0200039)2.52226317
23Pallor (HP:0000980)2.48712941
24Truncus arteriosus (HP:0001660)2.46816272
25Hyperacusis (HP:0010780)2.46595244
26Colon cancer (HP:0003003)2.44538170
27Nasal polyposis (HP:0100582)2.43358699
28Multiple enchondromatosis (HP:0005701)2.42865907
29Cholecystitis (HP:0001082)2.42448487
30Abnormal gallbladder physiology (HP:0012438)2.42448487
31Increased density of long bones (HP:0006392)2.40449820
32Macrocytic anemia (HP:0001972)2.40413485
33Distal lower limb muscle weakness (HP:0009053)2.37602309
34Recurrent viral infections (HP:0004429)2.37400810
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35341578
36Hypertensive crisis (HP:0100735)2.34423933
37Emphysema (HP:0002097)2.34053952
38Chronic otitis media (HP:0000389)2.31107647
39Long palpebral fissure (HP:0000637)2.30622879
40Insomnia (HP:0100785)2.29036252
41Papilloma (HP:0012740)2.28675304
42Verrucae (HP:0200043)2.28675304
43Premature skin wrinkling (HP:0100678)2.23828198
44Cerebral aneurysm (HP:0004944)2.20750821
45Abnormality of the nasal mucosa (HP:0000433)2.19636868
46Abnormality of reticulocytes (HP:0004312)2.19535258
47Microvesicular hepatic steatosis (HP:0001414)2.19222576
48Absent thumb (HP:0009777)2.17571288
49Ulnar bowing (HP:0003031)2.16555926
50Panhypogammaglobulinemia (HP:0003139)2.15098318
51Abnormality of the thoracic spine (HP:0100711)2.13148215
52Reticulocytosis (HP:0001923)2.13144166
53Breast hypoplasia (HP:0003187)2.12327109
54Patellar dislocation (HP:0002999)2.11965333
55Abnormality of the distal phalanges of the toes (HP:0010182)2.10650632
56Agammaglobulinemia (HP:0004432)2.09518848
57Gastrointestinal inflammation (HP:0004386)2.08371010
58Seborrheic dermatitis (HP:0001051)2.07765898
59Astrocytoma (HP:0009592)2.06749276
60Abnormality of the astrocytes (HP:0100707)2.06749276
61Oral leukoplakia (HP:0002745)2.06067416
62Protrusio acetabuli (HP:0003179)2.05596929
63Medulloblastoma (HP:0002885)2.04850752
64Back pain (HP:0003418)2.04628770
65Progressive external ophthalmoplegia (HP:0000590)2.03375742
66Septate vagina (HP:0001153)2.02144818
67Myopathic facies (HP:0002058)2.02068050
68Recurrent fungal infections (HP:0002841)2.02021646
69Abnormality of the umbilical cord (HP:0010881)2.01942990
70Disproportionate tall stature (HP:0001519)2.01904282
71Abnormality of T cells (HP:0002843)2.01679692
72Colitis (HP:0002583)2.01358947
73Abnormality of the tricuspid valve (HP:0001702)2.01126311
74Neoplasm of the pancreas (HP:0002894)2.00178693
75Hyperthyroidism (HP:0000836)2.00094513
76Flat acetabular roof (HP:0003180)1.99068145
77Carpal bone hypoplasia (HP:0001498)1.98539329
78Short nail (HP:0001799)1.97861694
79Agnosia (HP:0010524)1.95579930
80Deviation of the thumb (HP:0009603)1.95378574
81Birth length less than 3rd percentile (HP:0003561)1.93342512
82Progressive muscle weakness (HP:0003323)1.92150994
83Proximal placement of thumb (HP:0009623)1.91868462
84High pitched voice (HP:0001620)1.91642050
85Abnormality of the fingertips (HP:0001211)1.91303290
86Inflammation of the large intestine (HP:0002037)1.90874502
87Dysmetric saccades (HP:0000641)1.90869968
88Premature rupture of membranes (HP:0001788)1.90198121
89Amaurosis fugax (HP:0100576)1.89821591
90Lymphoma (HP:0002665)1.88847702
91Rough bone trabeculation (HP:0100670)1.88646661
92Microretrognathia (HP:0000308)1.88626438
93Stridor (HP:0010307)1.88180034
94T lymphocytopenia (HP:0005403)1.87402925
95Abnormality of T cell physiology (HP:0011840)1.87330762
96Biconcave vertebral bodies (HP:0004586)1.86282410
97Poikiloderma (HP:0001029)1.85679611
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.84398750
99Rhabdomyosarcoma (HP:0002859)1.84143346
100Distal upper limb amyotrophy (HP:0007149)1.83681113
101Upper limb amyotrophy (HP:0009129)1.83681113
102Missing ribs (HP:0000921)1.83438057
103Genu recurvatum (HP:0002816)1.82964727
104Deep palmar crease (HP:0006191)1.82913611
105Squamous cell carcinoma (HP:0002860)1.82726803
106Spastic diplegia (HP:0001264)1.82243872
107Self-mutilation (HP:0000742)1.81358162
108Patellar aplasia (HP:0006443)1.81327625
109Thoracic kyphosis (HP:0002942)1.80228564
110Persistence of primary teeth (HP:0006335)1.80083061
111Polygenic inheritance (HP:0010982)1.80048735
112Generalized amyotrophy (HP:0003700)1.79573966
113Abnormality of B cell number (HP:0010975)1.78644506
114B lymphocytopenia (HP:0010976)1.78644506
115Elevated erythrocyte sedimentation rate (HP:0003565)1.78263778
116Unilateral renal agenesis (HP:0000122)1.76463454
117Bowel incontinence (HP:0002607)1.76268537
118Overriding aorta (HP:0002623)1.75951384
11911 pairs of ribs (HP:0000878)1.75135799
120Abnormality of pyrimidine metabolism (HP:0004353)1.75023065
121Abnormality of the peritoneum (HP:0002585)1.74997081
122Abnormal large intestine physiology (HP:0012700)1.74471123
123Elbow flexion contracture (HP:0002987)1.73952012
124Neoplasm of striated muscle (HP:0009728)1.73473468
125Bicuspid aortic valve (HP:0001647)1.73244070
126Micronodular cirrhosis (HP:0001413)1.73100616
127Hypoparathyroidism (HP:0000829)1.73000111
128Entropion (HP:0000621)1.72618404
129Abnormality of the distal phalanx of the thumb (HP:0009617)1.72415152
130Lymphopenia (HP:0001888)1.72381656
131Aplasia/Hypoplasia of the patella (HP:0006498)1.71089398
132Skin tags (HP:0010609)1.69085625
133Impulsivity (HP:0100710)1.68324017
134Difficulty climbing stairs (HP:0003551)1.68314752
135Abnormality of the calcaneus (HP:0008364)1.68014133
136Abnormality of T cell number (HP:0011839)1.67977714
137Cutaneous melanoma (HP:0012056)1.67652674
138Abnormal number of incisors (HP:0011064)1.66675263
139Angiofibromas (HP:0010615)1.66610171
140Adenoma sebaceum (HP:0009720)1.66610171
141Myelodysplasia (HP:0002863)1.66373725
142Vertebral clefting (HP:0008428)1.66241962
143Ankle contracture (HP:0006466)1.66124613
144Asymmetry of the thorax (HP:0001555)1.65545705
145Pseudobulbar signs (HP:0002200)1.65470726
146Increased nuchal translucency (HP:0010880)1.63705728
147Lower limb amyotrophy (HP:0007210)1.63659602
148Bulbar palsy (HP:0001283)1.63341006
149Advanced eruption of teeth (HP:0006288)1.63334487
150Abnormality of the anterior horn cell (HP:0006802)1.62828660
151Degeneration of anterior horn cells (HP:0002398)1.62828660
152Prominent nose (HP:0000448)1.62381728
153Testicular atrophy (HP:0000029)1.61821925
154Premature ovarian failure (HP:0008209)1.61392571
155Natal tooth (HP:0000695)1.60075661
156Aplasia/Hypoplasia of the thymus (HP:0010515)1.59782773
157Sparse lateral eyebrow (HP:0005338)1.59223166
158Viral hepatitis (HP:0006562)1.59207547
159Tracheoesophageal fistula (HP:0002575)1.59149686
160Overlapping toe (HP:0001845)1.58315592
161Combined immunodeficiency (HP:0005387)1.58186196
162Abnormal delayed hypersensitivity skin test (HP:0002963)1.57976599
163Elfin facies (HP:0004428)1.57937351
164Preauricular skin tag (HP:0000384)1.57760416
165Atelectasis (HP:0100750)1.57655486
166Progressive hearing impairment (HP:0001730)1.56673100
167Pointed chin (HP:0000307)1.54967707
168Urethral obstruction (HP:0000796)1.54915017
169Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53467334
170Abnormality of skeletal muscle fiber size (HP:0012084)1.53412557
171Hypergonadotropic hypogonadism (HP:0000815)1.52555641
172Ankyloglossia (HP:0010296)1.52544577
173Abnormality of the fetal cardiovascular system (HP:0010948)1.52127424
174Single umbilical artery (HP:0001195)1.52127424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.93898319
2EEF2K3.92310979
3MAP3K103.30813969
4MAP4K13.25322306
5IRAK33.01998415
6RPS6KA42.73462224
7PKN22.71308110
8TRIB32.62334936
9BUB12.58793042
10PRPF4B2.46835133
11VRK22.37363308
12NEK22.36666189
13CDK122.25083049
14NME22.19258235
15STK102.18264417
16WEE12.04071394
17CDC72.03638009
18RPS6KB21.98442354
19ERN11.95695941
20LRRK21.70382382
21TESK21.69863795
22CDK41.64729753
23TLK11.64566038
24EPHA21.57992814
25EIF2AK11.57166189
26GRK61.52334043
27MAP3K81.43458578
28TYK21.35831973
29BLK1.32360934
30FLT31.32279195
31MST1R1.29782715
32ZAP701.28664829
33ALK1.27588855
34TAOK21.25997681
35KDR1.22179538
36SCYL21.21310460
37PASK1.19285074
38TSSK61.19063436
39DYRK31.16092144
40PIM11.15150515
41CDK71.13904199
42ARAF1.13682353
43TAF11.13446748
44MAPKAPK31.13284355
45TTK1.10019828
46TGFBR11.09168121
47BTK1.08240336
48FGFR41.08055897
49PAK41.03761716
50TTN1.02537153
51PTK61.00897433
52AURKB0.98924146
53CSF1R0.96557680
54JAK30.95987593
55MAP2K30.95880754
56NEK10.93006388
57CDK60.92830760
58ATR0.91388270
59RIPK10.89235474
60MTOR0.89157467
61TESK10.88442580
62CHEK10.87790096
63IRAK20.86819148
64PLK10.86474031
65PRKD30.85351526
66MAP3K110.84998429
67TBK10.82493994
68MAP3K130.81049503
69BRAF0.77834376
70STK40.74226155
71ACVR1B0.71755312
72PAK20.71424913
73PDGFRA0.71254164
74PRKD20.68650336
75BMX0.68628058
76CDK80.68625396
77CAMK1D0.67535349
78BRD40.66898479
79SRPK10.66779334
80IKBKB0.66674915
81PIM20.63798206
82IRAK40.62989119
83CHUK0.62620635
84ICK0.62086243
85CHEK20.62048982
86HCK0.61889179
87SYK0.61681886
88CDK20.60816787
89AURKA0.60066239
90KIT0.58923691
91RPS6KA50.56854893
92MAP3K10.56177242
93PAK10.55812106
94DAPK10.55642660
95RPS6KL10.55465016
96RPS6KC10.55465016
97LMTK20.55267204
98CSK0.52900467
99MAPK110.51944457
100NME10.51460533
101PTK20.51192746
102PDPK10.50887152
103SIK10.49271876
104LCK0.49040501
105TAOK10.48633756
106RPS6KA10.47995820
107TGFBR20.47837147
108HIPK20.46077833
109PBK0.45593173
110BRSK10.45488565
111BCKDK0.45095230
112RPS6KA20.44598812
113STK30.44492042
114CDK90.44007169
115BRSK20.43918193
116MELK0.42492562
117CSNK2A20.42204662
118STK160.41966921
119MARK20.41769370
120ITK0.41413924
121PRKCI0.40382007
122DAPK30.39941526
123KSR20.39693109
124MAP3K30.39594203
125ATM0.39448520
126CLK10.39351131
127CDC42BPA0.39242712
128LATS20.38948413
129ABL20.38843448
130MAP2K20.38788123
131ILK0.38741306
132MARK30.38480339
133MAPKAPK20.37586075
134AKT20.37545945
135MAP3K140.37232885
136EIF2AK30.36557600
137LYN0.36055822
138CDK10.35234680
139MET0.35024700

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80695284
2Ribosome_Homo sapiens_hsa030103.24029957
3Mismatch repair_Homo sapiens_hsa034302.99879567
4Spliceosome_Homo sapiens_hsa030402.90140882
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75944311
6Base excision repair_Homo sapiens_hsa034102.50538428
7RNA transport_Homo sapiens_hsa030132.44687007
8One carbon pool by folate_Homo sapiens_hsa006702.43969727
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34487200
10Primary immunodeficiency_Homo sapiens_hsa053402.24237083
11Cell cycle_Homo sapiens_hsa041101.95118292
12Nucleotide excision repair_Homo sapiens_hsa034201.78876716
13Homologous recombination_Homo sapiens_hsa034401.77972951
14Fructose and mannose metabolism_Homo sapiens_hsa000511.77929826
15RNA polymerase_Homo sapiens_hsa030201.76729277
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73403327
17Other glycan degradation_Homo sapiens_hsa005111.71481594
18p53 signaling pathway_Homo sapiens_hsa041151.59305511
19Antigen processing and presentation_Homo sapiens_hsa046121.56275421
20B cell receptor signaling pathway_Homo sapiens_hsa046621.51396955
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48637145
22Pyrimidine metabolism_Homo sapiens_hsa002401.46853784
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46504167
24Herpes simplex infection_Homo sapiens_hsa051681.38419265
25mRNA surveillance pathway_Homo sapiens_hsa030151.36471741
26Non-homologous end-joining_Homo sapiens_hsa034501.29856490
27Sulfur relay system_Homo sapiens_hsa041221.29451151
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.28977650
29Epstein-Barr virus infection_Homo sapiens_hsa051691.28877357
30Proteasome_Homo sapiens_hsa030501.27761548
31Viral carcinogenesis_Homo sapiens_hsa052031.27442561
32Chronic myeloid leukemia_Homo sapiens_hsa052201.23590650
33Acute myeloid leukemia_Homo sapiens_hsa052211.21968888
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.18166125
35Selenocompound metabolism_Homo sapiens_hsa004501.14713920
36Pentose phosphate pathway_Homo sapiens_hsa000301.14634779
37Fanconi anemia pathway_Homo sapiens_hsa034601.14330855
38Small cell lung cancer_Homo sapiens_hsa052221.11312918
39Systemic lupus erythematosus_Homo sapiens_hsa053221.09562346
40RNA degradation_Homo sapiens_hsa030181.06158838
41HTLV-I infection_Homo sapiens_hsa051661.05514995
42Measles_Homo sapiens_hsa051621.02896287
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01551346
44Apoptosis_Homo sapiens_hsa042100.95015423
45MicroRNAs in cancer_Homo sapiens_hsa052060.92586161
46Leishmaniasis_Homo sapiens_hsa051400.92360320
47Notch signaling pathway_Homo sapiens_hsa043300.91833778
48Vitamin B6 metabolism_Homo sapiens_hsa007500.91287391
49T cell receptor signaling pathway_Homo sapiens_hsa046600.89818128
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89437718
51Legionellosis_Homo sapiens_hsa051340.88309400
52Shigellosis_Homo sapiens_hsa051310.87961728
53Bladder cancer_Homo sapiens_hsa052190.85991077
54Thyroid cancer_Homo sapiens_hsa052160.85016187
55Prion diseases_Homo sapiens_hsa050200.84537024
56N-Glycan biosynthesis_Homo sapiens_hsa005100.84395643
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84253195
58Hepatitis B_Homo sapiens_hsa051610.81768050
59Prostate cancer_Homo sapiens_hsa052150.81601081
60Insulin signaling pathway_Homo sapiens_hsa049100.80928970
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80158068
62Osteoclast differentiation_Homo sapiens_hsa043800.78553265
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78191679
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77390740
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77171875
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75715615
67Glioma_Homo sapiens_hsa052140.75102221
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.74309593
69Folate biosynthesis_Homo sapiens_hsa007900.74162194
70Basal transcription factors_Homo sapiens_hsa030220.73225055
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72143976
72Influenza A_Homo sapiens_hsa051640.71896439
73Colorectal cancer_Homo sapiens_hsa052100.71771759
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.70863001
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70150846
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.69700985
77Hematopoietic cell lineage_Homo sapiens_hsa046400.69648340
78Non-small cell lung cancer_Homo sapiens_hsa052230.69617918
79Toxoplasmosis_Homo sapiens_hsa051450.69612439
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69312810
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68498834
82AMPK signaling pathway_Homo sapiens_hsa041520.68311063
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68249010
84Renal cell carcinoma_Homo sapiens_hsa052110.68036201
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67938256
86mTOR signaling pathway_Homo sapiens_hsa041500.67655880
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66285795
88Viral myocarditis_Homo sapiens_hsa054160.65202001
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64554917
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.63595117
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.63134371
92Pancreatic cancer_Homo sapiens_hsa052120.59612814
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59113971
94HIF-1 signaling pathway_Homo sapiens_hsa040660.58731996
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58662113
96Lysine degradation_Homo sapiens_hsa003100.57499351
97ErbB signaling pathway_Homo sapiens_hsa040120.56212603
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55998676
99Pyruvate metabolism_Homo sapiens_hsa006200.53708234
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.52900443
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.52566809
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52076056
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.51257120
104Proteoglycans in cancer_Homo sapiens_hsa052050.51049538
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49812955
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49429556
107VEGF signaling pathway_Homo sapiens_hsa043700.48804341
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48701365
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48253783
110Galactose metabolism_Homo sapiens_hsa000520.46250568
111Endometrial cancer_Homo sapiens_hsa052130.45487616
112Carbon metabolism_Homo sapiens_hsa012000.45218175
113Adherens junction_Homo sapiens_hsa045200.44780119
114Purine metabolism_Homo sapiens_hsa002300.44589801
115TNF signaling pathway_Homo sapiens_hsa046680.42645457
116Basal cell carcinoma_Homo sapiens_hsa052170.42114326
117Pathways in cancer_Homo sapiens_hsa052000.42065496
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41807137
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41327538
120Prolactin signaling pathway_Homo sapiens_hsa049170.40123984
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40072167
122Hippo signaling pathway_Homo sapiens_hsa043900.40009287
123Hepatitis C_Homo sapiens_hsa051600.39729615
124Insulin resistance_Homo sapiens_hsa049310.39380589
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39273655
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39262339
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.38594075
128Melanoma_Homo sapiens_hsa052180.38199768
129Phenylalanine metabolism_Homo sapiens_hsa003600.37806832
130Inositol phosphate metabolism_Homo sapiens_hsa005620.36774249

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