DDX53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein-chromophore linkage (GO:0018298)9.27466565
2inositol phosphate dephosphorylation (GO:0046855)7.34502449
3phosphorylated carbohydrate dephosphorylation (GO:0046838)7.34502449
4cullin deneddylation (GO:0010388)6.95782044
5establishment of protein localization to Golgi (GO:0072600)6.95488830
6protein targeting to Golgi (GO:0000042)6.94193829
7inositol phosphate catabolic process (GO:0071545)6.67935432
8retrograde transport, vesicle recycling within Golgi (GO:0000301)6.37807073
9platelet dense granule organization (GO:0060155)6.13817275
10protein deneddylation (GO:0000338)6.09745477
11polyol catabolic process (GO:0046174)6.01863476
12inositol metabolic process (GO:0006020)5.93269033
13synapsis (GO:0007129)5.77828033
14proline transport (GO:0015824)5.68053953
15mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.66991428
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.66991428
17regulation of cilium movement (GO:0003352)5.61966588
18protein localization to Golgi apparatus (GO:0034067)5.45005134
19microtubule depolymerization (GO:0007019)5.34047648
20vitamin transmembrane transport (GO:0035461)5.15611485
21response to misfolded protein (GO:0051788)5.15236624
22early endosome to late endosome transport (GO:0045022)5.14218649
23regulation of vesicle fusion (GO:0031338)5.13853458
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.02622209
25piRNA metabolic process (GO:0034587)4.87808110
26rhodopsin mediated signaling pathway (GO:0016056)4.67108086
27DNA methylation involved in gamete generation (GO:0043046)4.63579301
28microtubule nucleation (GO:0007020)4.61339365
29transepithelial transport (GO:0070633)4.57660102
30regulation of Rac protein signal transduction (GO:0035020)4.56614035
31negative regulation of exocytosis (GO:0045920)4.54639550
32photoreceptor cell maintenance (GO:0045494)4.53139021
33regulation of microtubule-based movement (GO:0060632)4.50251385
34histone H2A ubiquitination (GO:0033522)4.41757466
35chromosome organization involved in meiosis (GO:0070192)4.38511170
36L-ascorbic acid metabolic process (GO:0019852)4.36159648
37regulation of sequestering of triglyceride (GO:0010889)4.28105410
38male meiosis I (GO:0007141)4.21859065
39microtubule polymerization or depolymerization (GO:0031109)4.16691170
40retinol metabolic process (GO:0042572)4.14687974
41anterograde synaptic vesicle transport (GO:0048490)4.12848556
42DNA replication-dependent nucleosome assembly (GO:0006335)4.02915927
43DNA replication-dependent nucleosome organization (GO:0034723)4.02915927
44alanine transport (GO:0032328)4.01671702
45misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.01431052
46protein polyglutamylation (GO:0018095)3.97577196
47ADP metabolic process (GO:0046031)3.93861394
48protein K11-linked deubiquitination (GO:0035871)3.91376133
49protein K48-linked deubiquitination (GO:0071108)3.85400986
50peptidyl-threonine dephosphorylation (GO:0035970)3.83999419
51positive regulation of mitochondrial membrane permeability (GO:0035794)3.80884640
52male meiosis (GO:0007140)3.78491319
53phosphatidylinositol phosphorylation (GO:0046854)3.78318507
54endosome organization (GO:0007032)3.76742456
55righting reflex (GO:0060013)3.74280149
56receptor recycling (GO:0001881)3.67056517
57auditory behavior (GO:0031223)3.65427808
58synaptonemal complex assembly (GO:0007130)3.61595566
59attachment of spindle microtubules to kinetochore (GO:0008608)3.55466435
60meiotic nuclear division (GO:0007126)3.37412176
61sperm motility (GO:0030317)3.36715307
62artery development (GO:0060840)3.36431112
63meiotic chromosome segregation (GO:0045132)3.32718059
64intra-Golgi vesicle-mediated transport (GO:0006891)3.32468756
65axoneme assembly (GO:0035082)3.31749483
66meiosis I (GO:0007127)3.31037254
67synaptonemal complex organization (GO:0070193)3.26729562
68protein K11-linked ubiquitination (GO:0070979)3.20876624
69short-term memory (GO:0007614)3.17784893
70thyroid gland development (GO:0030878)3.14917657
71epithelial cilium movement (GO:0003351)3.11446308
72reflex (GO:0060004)3.09506578
73histone mRNA catabolic process (GO:0071044)3.09298225
74behavioral response to ethanol (GO:0048149)3.06830579
75mechanosensory behavior (GO:0007638)3.06129092
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.06040858
77regulation of mitotic spindle checkpoint (GO:1903504)3.06040858
78positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)3.04068477
79positive regulation of dendritic spine morphogenesis (GO:0061003)3.03762747
80folic acid-containing compound biosynthetic process (GO:0009396)3.02069139
81rRNA catabolic process (GO:0016075)3.01488883
82anterograde axon cargo transport (GO:0008089)2.99851536
83negative regulation of cAMP-mediated signaling (GO:0043951)2.99117470
84detection of light stimulus involved in sensory perception (GO:0050962)2.97167744
85detection of light stimulus involved in visual perception (GO:0050908)2.97167744
86lipid phosphorylation (GO:0046834)2.96194812
87DNA synthesis involved in DNA repair (GO:0000731)2.92621739
88postreplication repair (GO:0006301)2.90894533
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.87724081
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.87724081
91histone H3-K9 methylation (GO:0051567)2.87014547
92otic vesicle formation (GO:0030916)2.85445435
93acrosome reaction (GO:0007340)2.85381133
94regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.83719731
95positive regulation of cell cycle G1/S phase transition (GO:1902808)2.83544839
96sister chromatid cohesion (GO:0007062)2.83321256
97positive regulation of cAMP-mediated signaling (GO:0043950)2.81720431
98behavioral response to nicotine (GO:0035095)2.81065582
99centriole replication (GO:0007099)2.79836297
100histone H3-K9 demethylation (GO:0033169)2.76928919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human5.17163382
2IGF1R_20145208_ChIP-Seq_DFB_Human4.07425998
3ZFP57_27257070_Chip-Seq_ESCs_Mouse3.27879970
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.13055409
5FUS_26573619_Chip-Seq_HEK293_Human2.83320453
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.76739729
7GBX2_23144817_ChIP-Seq_PC3_Human2.69161629
8ER_23166858_ChIP-Seq_MCF-7_Human2.51664799
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43315601
10ZNF274_21170338_ChIP-Seq_K562_Hela2.42007995
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.32691647
12EZH2_22144423_ChIP-Seq_EOC_Human2.27682344
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25604216
14P300_19829295_ChIP-Seq_ESCs_Human2.18406391
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05551181
16AR_21572438_ChIP-Seq_LNCaP_Human2.00918687
17EWS_26573619_Chip-Seq_HEK293_Human1.94670535
18PRDM14_20953172_ChIP-Seq_ESCs_Human1.83455271
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82402304
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.80964488
21SOX2_19829295_ChIP-Seq_ESCs_Human1.75570463
22NANOG_19829295_ChIP-Seq_ESCs_Human1.75570463
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73761791
24STAT3_23295773_ChIP-Seq_U87_Human1.72170918
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70507023
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65755691
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.65755691
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64336992
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60525932
30E2F7_22180533_ChIP-Seq_HELA_Human1.58283602
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.56806757
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56150000
33TP53_22573176_ChIP-Seq_HFKS_Human1.55660677
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53794848
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52509590
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.52509590
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52499829
38TCF4_23295773_ChIP-Seq_U87_Human1.52011725
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50328944
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49767685
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47726845
42AR_25329375_ChIP-Seq_VCAP_Human1.47394758
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46328113
44SMAD4_21799915_ChIP-Seq_A2780_Human1.42564709
45SMAD4_21741376_ChIP-Seq_EPCs_Human1.41745771
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.41743671
47* RUNX2_22187159_ChIP-Seq_PCA_Human1.38814422
48RNF2_27304074_Chip-Seq_NSC_Mouse1.38711956
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.37825065
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34815917
51NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33168440
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.32008879
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.29857544
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.29654293
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29531125
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28951636
57REST_21632747_ChIP-Seq_MESCs_Mouse1.28528770
58TCF4_22108803_ChIP-Seq_LS180_Human1.28153490
59TAF15_26573619_Chip-Seq_HEK293_Human1.27204836
60JUN_21703547_ChIP-Seq_K562_Human1.21812494
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20755997
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20606830
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.20500261
64ETV1_20927104_ChIP-Seq_GIST48_Human1.20270254
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19842992
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19275799
67BCAT_22108803_ChIP-Seq_LS180_Human1.18934030
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18490349
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.18224475
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18057098
71CBP_20019798_ChIP-Seq_JUKART_Human1.18057098
72MYC_18940864_ChIP-ChIP_HL60_Human1.17985924
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16549840
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16160838
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15921270
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14896706
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13778315
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.12872729
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12819546
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.12803595
81HTT_18923047_ChIP-ChIP_STHdh_Human1.12330441
82NMYC_18555785_Chip-Seq_ESCs_Mouse1.11862372
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11252199
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08359158
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08184445
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07231473
87OCT4_20526341_ChIP-Seq_ESCs_Human1.07213793
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.06354654
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05331447
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.05313751
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05217756
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04792735
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04738191
94IRF1_19129219_ChIP-ChIP_H3396_Human1.04527950
95AR_20517297_ChIP-Seq_VCAP_Human1.03616420
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01641627
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.01503902
98RBPJ_21746931_ChIP-Seq_IB4_Human1.01146047
99P53_22387025_ChIP-Seq_ESCs_Mouse1.01008178
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00891012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.93031410
2MP0005083_abnormal_biliary_tract8.02624604
3MP0002638_abnormal_pupillary_reflex6.29250383
4MP0005085_abnormal_gallbladder_physiolo4.94270929
5MP0005084_abnormal_gallbladder_morpholo4.51818605
6MP0005365_abnormal_bile_salt3.82206667
7MP0001764_abnormal_homeostasis2.84769367
8MP0002928_abnormal_bile_duct2.80077252
9MP0006072_abnormal_retinal_apoptosis2.70362663
10MP0005253_abnormal_eye_physiology2.65701072
11MP0010386_abnormal_urinary_bladder2.37534673
12MP0008877_abnormal_DNA_methylation2.09012935
13MP0005379_endocrine/exocrine_gland_phen2.02683888
14MP0005551_abnormal_eye_electrophysiolog2.01078432
15MP0001502_abnormal_circadian_rhythm1.86569675
16MP0003943_abnormal_hepatobiliary_system1.84491475
17MP0005410_abnormal_fertilization1.75040312
18MP0002160_abnormal_reproductive_system1.74683362
19MP0002102_abnormal_ear_morphology1.66149863
20MP0001501_abnormal_sleep_pattern1.40597787
21MP0002909_abnormal_adrenal_gland1.39635105
22MP0004859_abnormal_synaptic_plasticity1.36630952
23MP0008058_abnormal_DNA_repair1.35672250
24MP0003950_abnormal_plasma_membrane1.26379125
25MP0003195_calcinosis1.25111386
26MP0005310_abnormal_salivary_gland1.21427722
27MP0000427_abnormal_hair_cycle1.16656386
28MP0003698_abnormal_male_reproductive1.14949085
29MP0003136_yellow_coat_color1.06764428
30MP0000569_abnormal_digit_pigmentation1.06109182
31MP0002210_abnormal_sex_determination1.04411531
32MP0001929_abnormal_gametogenesis1.00874896
33MP0001905_abnormal_dopamine_level0.98662886
34MP0004019_abnormal_vitamin_homeostasis0.95714511
35MP0009046_muscle_twitch0.95571519
36MP0003122_maternal_imprinting0.94148263
37MP0001529_abnormal_vocalization0.89744639
38MP0008775_abnormal_heart_ventricle0.89497431
39MP0003718_maternal_effect0.89326117
40MP0005391_vision/eye_phenotype0.89313331
41MP0005389_reproductive_system_phenotype0.86005340
42MP0004043_abnormal_pH_regulation0.84965247
43MP0005647_abnormal_sex_gland0.84224951
44MP0005595_abnormal_vascular_smooth0.83374713
45MP0002138_abnormal_hepatobiliary_system0.83346497
46MP0000538_abnormal_urinary_bladder0.83106024
47MP0002184_abnormal_innervation0.83032530
48MP0006082_CNS_inflammation0.81793336
49MP0002272_abnormal_nervous_system0.80166195
50MP0005646_abnormal_pituitary_gland0.79498178
51MP0003646_muscle_fatigue0.79432954
52MP0002752_abnormal_somatic_nervous0.79114033
53MP0005220_abnormal_exocrine_pancreas0.76865527
54MP0002572_abnormal_emotion/affect_behav0.75172306
55MP0004957_abnormal_blastocyst_morpholog0.74143555
56MP0010094_abnormal_chromosome_stability0.73248288
57MP0000230_abnormal_systemic_arterial0.71779000
58MP0003693_abnormal_embryo_hatching0.70538984
59MP0001145_abnormal_male_reproductive0.68302968
60MP0000653_abnormal_sex_gland0.67074164
61MP0005397_hematopoietic_system_phenotyp0.66970682
62MP0001545_abnormal_hematopoietic_system0.66970682
63MP0005195_abnormal_posterior_eye0.66255002
64MP0005376_homeostasis/metabolism_phenot0.62370372
65MP0003656_abnormal_erythrocyte_physiolo0.61752695
66MP0008995_early_reproductive_senescence0.61190189
67MP0009745_abnormal_behavioral_response0.60882309
68MP0002234_abnormal_pharynx_morphology0.57486838
69MP0003806_abnormal_nucleotide_metabolis0.57182212
70MP0003137_abnormal_impulse_conducting0.56393909
71MP0002064_seizures0.55351530
72MP0003121_genomic_imprinting0.55126614
73MP0008932_abnormal_embryonic_tissue0.54202280
74MP0002971_abnormal_brown_adipose0.53070742
75MP0001968_abnormal_touch/_nociception0.51681763
76MP0002229_neurodegeneration0.51503683
77MP0000383_abnormal_hair_follicle0.51188195
78MP0002063_abnormal_learning/memory/cond0.50306903
79MP0002282_abnormal_trachea_morphology0.49922650
80MP0002161_abnormal_fertility/fecundity0.49184729
81MP0006276_abnormal_autonomic_nervous0.48649583
82MP0005167_abnormal_blood-brain_barrier0.47910046
83MP0000372_irregular_coat_pigmentation0.47405810
84MP0000639_abnormal_adrenal_gland0.46838507
85MP0003183_abnormal_peptide_metabolism0.46563725
86MP0009780_abnormal_chondrocyte_physiolo0.45981744
87MP0001119_abnormal_female_reproductive0.45626982
88MP0005645_abnormal_hypothalamus_physiol0.45523351
89MP0009697_abnormal_copulation0.45454119
90MP0003635_abnormal_synaptic_transmissio0.45363134
91MP0004924_abnormal_behavior0.45313530
92MP0005386_behavior/neurological_phenoty0.45313530
93MP0002733_abnormal_thermal_nociception0.45224028
94MP0001440_abnormal_grooming_behavior0.45184585
95MP0001664_abnormal_digestion0.44159364
96MP0009672_abnormal_birth_weight0.43965423
97MP0003868_abnormal_feces_composition0.43555033
98MP0004215_abnormal_myocardial_fiber0.43192509
99MP0003567_abnormal_fetal_cardiomyocyte0.42856653
100MP0004084_abnormal_cardiac_muscle0.41628469

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)6.14800435
2Azoospermia (HP:0000027)5.76494000
3Amyotrophic lateral sclerosis (HP:0007354)5.02762211
4Abnormal spermatogenesis (HP:0008669)4.60545118
5Abnormal hair whorl (HP:0010721)4.50393721
6Atrophy/Degeneration involving motor neurons (HP:0007373)4.35002851
7Abnormality of the lower motor neuron (HP:0002366)4.10986309
8Abnormality of the renal cortex (HP:0011035)4.06043747
9Nephronophthisis (HP:0000090)4.00117772
10Progressive inability to walk (HP:0002505)3.98845221
11Pancreatic cysts (HP:0001737)3.94128050
12Upper motor neuron abnormality (HP:0002127)3.85711242
13Renal cortical cysts (HP:0000803)3.76720151
14Broad face (HP:0000283)3.75035668
15Hand muscle atrophy (HP:0009130)3.64606964
16Urethral obstruction (HP:0000796)3.63977639
17Molar tooth sign on MRI (HP:0002419)3.60913196
18Abnormality of midbrain morphology (HP:0002418)3.60913196
19Tetraplegia (HP:0002445)3.60863484
20Inability to walk (HP:0002540)3.54651111
21Absent/shortened dynein arms (HP:0200106)3.40785182
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.40785182
23Abnormality of the corticospinal tract (HP:0002492)3.34078226
24True hermaphroditism (HP:0010459)3.15076261
25Abnormality of the renal medulla (HP:0100957)3.03399023
26Abnormality of the anterior horn cell (HP:0006802)2.98217299
27Degeneration of anterior horn cells (HP:0002398)2.98217299
28Pancreatic fibrosis (HP:0100732)2.96856533
29Congenital stationary night blindness (HP:0007642)2.96209407
30Attenuation of retinal blood vessels (HP:0007843)2.88148727
31Bony spicule pigmentary retinopathy (HP:0007737)2.82466913
32Tubular atrophy (HP:0000092)2.78416573
33Type II lissencephaly (HP:0007260)2.78022163
34Chronic hepatic failure (HP:0100626)2.74050079
35Distal upper limb amyotrophy (HP:0007149)2.54617325
36Upper limb amyotrophy (HP:0009129)2.54617325
37Prominent supraorbital ridges (HP:0000336)2.49211116
38Proximal tubulopathy (HP:0000114)2.48893627
39Tachypnea (HP:0002789)2.48168003
40Spastic tetraplegia (HP:0002510)2.41207574
41Type II diabetes mellitus (HP:0005978)2.38841581
42Sclerocornea (HP:0000647)2.36556904
43Spastic tetraparesis (HP:0001285)2.29682921
44Cystic liver disease (HP:0006706)2.28548957
45Pseudobulbar signs (HP:0002200)2.27765264
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24705902
47Concave nail (HP:0001598)2.23849827
48Abnormality of the renal collecting system (HP:0004742)2.22877804
49Anterior segment dysgenesis (HP:0007700)2.19685375
50Drooling (HP:0002307)2.17950970
51Downturned corners of mouth (HP:0002714)2.16245549
52Abnormal respiratory epithelium morphology (HP:0012253)2.14103121
53Abnormal respiratory motile cilium morphology (HP:0005938)2.14103121
54Duplicated collecting system (HP:0000081)2.13967200
55Photophobia (HP:0000613)2.13761208
56Hypoplastic ischia (HP:0003175)2.10488889
57Morphological abnormality of the pyramidal tract (HP:0002062)2.10464920
58Stomach cancer (HP:0012126)2.10323329
59Abnormal ciliary motility (HP:0012262)2.04469460
60Methylmalonic acidemia (HP:0002912)2.03116226
61Postural instability (HP:0002172)2.01256523
62Stage 5 chronic kidney disease (HP:0003774)2.00847698
63Abolished electroretinogram (ERG) (HP:0000550)1.98745898
64Aplasia/Hypoplasia of the tibia (HP:0005772)1.97562046
65Abnormal auditory evoked potentials (HP:0006958)1.97128736
66Gonadotropin excess (HP:0000837)1.95692160
67Increased number of teeth (HP:0011069)1.95471049
68Excessive salivation (HP:0003781)1.95128731
69Constricted visual fields (HP:0001133)1.94052563
70Spastic paraplegia (HP:0001258)1.92187244
71Anencephaly (HP:0002323)1.92015217
72Congenital hepatic fibrosis (HP:0002612)1.91788908
73Generalized aminoaciduria (HP:0002909)1.90854472
74Abnormal drinking behavior (HP:0030082)1.90252316
75Polydipsia (HP:0001959)1.90252316
76Medial flaring of the eyebrow (HP:0010747)1.89852972
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.89270397
78Gaze-evoked nystagmus (HP:0000640)1.88946881
79Retinal dysplasia (HP:0007973)1.87386840
80Childhood onset (HP:0011463)1.87246256
81Resting tremor (HP:0002322)1.86108951
82Abnormal respiratory motile cilium physiology (HP:0012261)1.82779383
83Bile duct proliferation (HP:0001408)1.80188820
84Abnormal biliary tract physiology (HP:0012439)1.80188820
85Chronic bronchitis (HP:0004469)1.79837163
86Adactyly (HP:0009776)1.79720603
87Truncal obesity (HP:0001956)1.79312570
88Abnormality of the motor neurons (HP:0002450)1.77962305
89Abnormal neuron morphology (HP:0012757)1.77962305
90Abnormality of the ischium (HP:0003174)1.77366599
91Tetany (HP:0001281)1.77272677
92Rhinitis (HP:0012384)1.74354864
93Akinesia (HP:0002304)1.74230313
94Diminished movement (HP:0002374)1.71729724
95Abnormality of salivation (HP:0100755)1.68976467
96Methylmalonic aciduria (HP:0012120)1.68739565
97Abnormality of ocular smooth pursuit (HP:0000617)1.68025093
98Short foot (HP:0001773)1.65876740
99Amelogenesis imperfecta (HP:0000705)1.64693301
100Abnormal gallbladder physiology (HP:0012438)1.62795503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK18.58954911
2NME17.80046132
3FRK3.88098323
4NEK23.30777148
5PINK12.72902084
6PLK42.64442231
7PIK3CG2.30975020
8MAPK132.22118670
9ERBB31.86531287
10TESK11.82737573
11NUAK11.67029749
12MAP4K21.64076217
13MAP3K91.59821993
14PRKD31.56718213
15EIF2AK11.56006082
16GRK11.51512095
17PTK2B1.39428145
18PNCK1.38663056
19BRD41.29239980
20LIMK11.25807746
21ADRBK21.24986923
22OXSR11.24178677
23LATS11.18312391
24MAPKAPK51.17866085
25EIF2AK31.15123008
26PLK21.12272672
27MARK11.01269855
28MAP3K40.99330066
29STK38L0.95191575
30ACVR1B0.92112667
31CAMK1G0.84187915
32NTRK30.82550474
33WNK30.81964705
34CAMKK20.79935043
35CASK0.78135003
36STK390.69435474
37WNK40.68357228
38MET0.63959306
39ARAF0.63858439
40TSSK60.62758577
41INSRR0.62348670
42TAOK30.59379200
43CAMK1D0.56805467
44EEF2K0.55380804
45PRKCG0.55379166
46DAPK20.52775943
47WEE10.52186421
48PRKCQ0.49807431
49BMPR1B0.49571685
50AURKA0.48222011
51NEK60.46552109
52RPS6KB10.45984436
53CAMK40.45617607
54ADRBK10.45043734
55STK30.44940564
56ROCK10.44896871
57BLK0.42445974
58NEK90.42332930
59CCNB10.41572275
60TYK20.39413921
61CDK10.38713792
62PIM20.38021833
63RAF10.37908170
64PRKACB0.37483929
65PRKAA20.35859053
66TIE10.35716991
67NTRK20.33132811
68PASK0.31348034
69MAP2K70.29773596
70UHMK10.27680063
71CSNK1G20.27412402
72BMX0.26976222
73PRKCE0.26074257
74PDK10.25774091
75BCR0.25654893
76ROCK20.25610040
77PRKCB0.25181622
78PDPK10.24816521
79MAPKAPK30.24506594
80TEC0.24371718
81RPS6KB20.24327391
82PRKG20.23263301
83EGFR0.22350009
84CAMK10.22007077
85PRKCI0.21966427
86MAP3K20.21520257
87DYRK20.21396489
88BRSK20.21244431
89CAMK2A0.20201267
90MARK30.19274838
91AKT20.19229730
92TLK10.19228289
93PLK10.19214076
94PRKACA0.19145910
95CSNK1E0.18089174
96TRPM70.17862186
97PRKG10.17550804
98PKN10.15746700
99BUB10.15313021
100TRIM280.15006641

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.56855002
2One carbon pool by folate_Homo sapiens_hsa006703.03457301
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.88662454
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.84610785
5Linoleic acid metabolism_Homo sapiens_hsa005912.75075209
6Retinol metabolism_Homo sapiens_hsa008302.69188349
7Regulation of autophagy_Homo sapiens_hsa041402.53701791
8Phototransduction_Homo sapiens_hsa047442.50638835
9Inositol phosphate metabolism_Homo sapiens_hsa005622.34892677
10Basal transcription factors_Homo sapiens_hsa030222.29296999
11Olfactory transduction_Homo sapiens_hsa047402.23854150
12Fatty acid biosynthesis_Homo sapiens_hsa000612.22132856
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.19800491
14Non-homologous end-joining_Homo sapiens_hsa034502.04406340
15Fanconi anemia pathway_Homo sapiens_hsa034601.95776299
16Nitrogen metabolism_Homo sapiens_hsa009101.78278320
17Nicotine addiction_Homo sapiens_hsa050331.76600596
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75297372
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.75174812
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74908730
21Butanoate metabolism_Homo sapiens_hsa006501.70447335
22Taste transduction_Homo sapiens_hsa047421.66223308
23Tryptophan metabolism_Homo sapiens_hsa003801.63012663
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62256974
25RNA degradation_Homo sapiens_hsa030181.61038639
26Ether lipid metabolism_Homo sapiens_hsa005651.56155523
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50643396
28Homologous recombination_Homo sapiens_hsa034401.50028054
29Propanoate metabolism_Homo sapiens_hsa006401.38450694
30Arachidonic acid metabolism_Homo sapiens_hsa005901.38414410
31Morphine addiction_Homo sapiens_hsa050321.33468829
32RNA transport_Homo sapiens_hsa030131.32688439
33Salivary secretion_Homo sapiens_hsa049701.24071465
34Dorso-ventral axis formation_Homo sapiens_hsa043201.20898887
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19955449
36Histidine metabolism_Homo sapiens_hsa003401.17801938
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.16103641
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15398260
39Fatty acid metabolism_Homo sapiens_hsa012121.15109452
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14198818
41Fatty acid degradation_Homo sapiens_hsa000711.13431459
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13280714
43ABC transporters_Homo sapiens_hsa020101.10474101
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07320714
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07024691
46Lysine degradation_Homo sapiens_hsa003101.00800658
47Caffeine metabolism_Homo sapiens_hsa002321.00613426
48Arginine and proline metabolism_Homo sapiens_hsa003301.00323323
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00210051
50Chemical carcinogenesis_Homo sapiens_hsa052040.95362072
51Glycerolipid metabolism_Homo sapiens_hsa005610.94386686
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92327643
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90246723
54Oocyte meiosis_Homo sapiens_hsa041140.85274633
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.83584834
56beta-Alanine metabolism_Homo sapiens_hsa004100.82910476
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81459796
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79949720
59Circadian entrainment_Homo sapiens_hsa047130.74615941
60Fat digestion and absorption_Homo sapiens_hsa049750.73676572
61Purine metabolism_Homo sapiens_hsa002300.72151335
62Mismatch repair_Homo sapiens_hsa034300.70940100
63Calcium signaling pathway_Homo sapiens_hsa040200.68053480
64Metabolic pathways_Homo sapiens_hsa011000.67817498
65PPAR signaling pathway_Homo sapiens_hsa033200.67794228
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67347538
67Pyruvate metabolism_Homo sapiens_hsa006200.66842660
68Gastric acid secretion_Homo sapiens_hsa049710.66183669
69Insulin secretion_Homo sapiens_hsa049110.65999319
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65736707
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62069947
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62032111
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.58495189
74Glutathione metabolism_Homo sapiens_hsa004800.57694979
75Huntingtons disease_Homo sapiens_hsa050160.57406098
76Nucleotide excision repair_Homo sapiens_hsa034200.56546048
77Vitamin B6 metabolism_Homo sapiens_hsa007500.55582211
78Vitamin digestion and absorption_Homo sapiens_hsa049770.54269088
79Glutamatergic synapse_Homo sapiens_hsa047240.53393608
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52595067
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52523347
82Sphingolipid metabolism_Homo sapiens_hsa006000.49049833
83GABAergic synapse_Homo sapiens_hsa047270.48755328
84Serotonergic synapse_Homo sapiens_hsa047260.46094947
85Cell cycle_Homo sapiens_hsa041100.43812404
86Steroid biosynthesis_Homo sapiens_hsa001000.39428250
87Cardiac muscle contraction_Homo sapiens_hsa042600.39320092
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34487262
89Cholinergic synapse_Homo sapiens_hsa047250.32744923
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32273568
91Bile secretion_Homo sapiens_hsa049760.31275659
92Circadian rhythm_Homo sapiens_hsa047100.30916416
93Parkinsons disease_Homo sapiens_hsa050120.29962441
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.29705980
95Long-term depression_Homo sapiens_hsa047300.28806199
96mRNA surveillance pathway_Homo sapiens_hsa030150.27473185
97TGF-beta signaling pathway_Homo sapiens_hsa043500.26791411
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22347420
99Base excision repair_Homo sapiens_hsa034100.20681527
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20011937

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