DDX46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.60605390
2nuclear pore organization (GO:0006999)5.36645846
3ribosomal small subunit biogenesis (GO:0042274)5.24863762
4DNA unwinding involved in DNA replication (GO:0006268)4.80917903
5protein localization to kinetochore (GO:0034501)4.78824812
6mitotic sister chromatid cohesion (GO:0007064)4.75033184
7establishment of integrated proviral latency (GO:0075713)4.37278694
8pore complex assembly (GO:0046931)4.33772963
9mitotic metaphase plate congression (GO:0007080)4.25275447
10protein localization to chromosome, centromeric region (GO:0071459)4.20415707
11mitotic chromosome condensation (GO:0007076)4.09203126
12mitotic nuclear envelope disassembly (GO:0007077)4.08609012
13metaphase plate congression (GO:0051310)3.89762336
14DNA replication initiation (GO:0006270)3.88891107
15ribosomal large subunit biogenesis (GO:0042273)3.88389065
16regulation of RNA export from nucleus (GO:0046831)3.86501620
17sister chromatid segregation (GO:0000819)3.81823484
18ribonucleoprotein complex biogenesis (GO:0022613)3.80629090
19membrane disassembly (GO:0030397)3.80299068
20nuclear envelope disassembly (GO:0051081)3.80299068
21DNA duplex unwinding (GO:0032508)3.78755391
22DNA geometric change (GO:0032392)3.76424611
23pre-miRNA processing (GO:0031054)3.75759295
24kinetochore organization (GO:0051383)3.75289628
25DNA strand elongation involved in DNA replication (GO:0006271)3.74739416
26mitotic sister chromatid segregation (GO:0000070)3.74695487
27heterochromatin organization (GO:0070828)3.73397637
28translational termination (GO:0006415)3.70965942
29viral transcription (GO:0019083)3.69288696
30regulation of histone H3-K9 methylation (GO:0051570)3.68297658
31DNA replication checkpoint (GO:0000076)3.67313029
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66141436
33negative regulation of histone methylation (GO:0031061)3.60898560
34IMP biosynthetic process (GO:0006188)3.60259191
35regulation of translational fidelity (GO:0006450)3.58716725
36DNA strand elongation (GO:0022616)3.56241004
37positive regulation of chromosome segregation (GO:0051984)3.55383248
38regulation of spindle organization (GO:0090224)3.51447847
39regulation of sister chromatid cohesion (GO:0007063)3.50700552
40establishment of chromosome localization (GO:0051303)3.50060931
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48150335
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48150335
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.48150335
44rRNA processing (GO:0006364)3.44192748
45protein localization to chromosome (GO:0034502)3.41475759
46negative regulation of RNA splicing (GO:0033119)3.40371736
47nucleotide-excision repair, DNA gap filling (GO:0006297)3.40265127
48meiotic chromosome segregation (GO:0045132)3.39620179
49regulation of mitotic spindle organization (GO:0060236)3.38891596
50DNA replication-dependent nucleosome organization (GO:0034723)3.37861779
51DNA replication-dependent nucleosome assembly (GO:0006335)3.37861779
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36953151
53rRNA metabolic process (GO:0016072)3.34658545
54positive regulation of histone H3-K4 methylation (GO:0051571)3.31386177
55ribosomal small subunit assembly (GO:0000028)3.28723126
56regulation of centrosome duplication (GO:0010824)3.28226739
57translational initiation (GO:0006413)3.27587217
58DNA conformation change (GO:0071103)3.26814722
59attachment of spindle microtubules to kinetochore (GO:0008608)3.26778921
60negative regulation of mRNA processing (GO:0050686)3.26337917
61double-strand break repair via nonhomologous end joining (GO:0006303)3.25422551
62non-recombinational repair (GO:0000726)3.25422551
63establishment of viral latency (GO:0019043)3.24408054
64regulation of nuclear cell cycle DNA replication (GO:0033262)3.24287580
65replication fork processing (GO:0031297)3.23777140
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22275950
67folic acid-containing compound biosynthetic process (GO:0009396)3.20963762
68telomere maintenance via semi-conservative replication (GO:0032201)3.20753668
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20605645
70DNA replication-independent nucleosome organization (GO:0034724)3.20108680
71DNA replication-independent nucleosome assembly (GO:0006336)3.20108680
72chromatin assembly or disassembly (GO:0006333)3.19003226
73regulation of DNA endoreduplication (GO:0032875)3.17389471
74monoubiquitinated protein deubiquitination (GO:0035520)3.16577586
75mitotic recombination (GO:0006312)3.16217720
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.15481093
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15439660
78IMP metabolic process (GO:0046040)3.13869230
79DNA ligation (GO:0006266)3.13837762
80cotranslational protein targeting to membrane (GO:0006613)3.13358679
81translational elongation (GO:0006414)3.12114179
82mRNA stabilization (GO:0048255)3.11888697
83RNA stabilization (GO:0043489)3.11888697
84chromatin remodeling at centromere (GO:0031055)3.11399847
85DNA topological change (GO:0006265)3.10606252
86regulation of centriole replication (GO:0046599)3.10466222
87nucleobase biosynthetic process (GO:0046112)3.09846546
88alternative mRNA splicing, via spliceosome (GO:0000380)3.09532563
89protein targeting to ER (GO:0045047)3.08992449
90ATP-dependent chromatin remodeling (GO:0043044)3.08704677
91termination of RNA polymerase II transcription (GO:0006369)3.08510400
92telomere maintenance via recombination (GO:0000722)3.07706590
93dosage compensation (GO:0007549)3.07469074
94translesion synthesis (GO:0019985)3.06765081
95negative regulation of mRNA metabolic process (GO:1903312)3.06730561
96regulation of chromosome segregation (GO:0051983)3.05443157
97kinetochore assembly (GO:0051382)3.05308421
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.04968685
99somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04968685
100regulation of centrosome cycle (GO:0046605)3.04571246
101regulation of nucleobase-containing compound transport (GO:0032239)3.02736829
102establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01887529
103CENP-A containing nucleosome assembly (GO:0034080)3.00874691
104formation of translation preinitiation complex (GO:0001731)3.00773936
105mRNA transport (GO:0051028)2.99235036
106nuclear envelope organization (GO:0006998)2.98681924
107chromosome condensation (GO:0030261)2.96041215
108RNA splicing, via transesterification reactions (GO:0000375)2.95208267
109mRNA splicing, via spliceosome (GO:0000398)2.94690508
110RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94690508
111chromatin assembly (GO:0031497)2.94657432
112sister chromatid cohesion (GO:0007062)2.93996757
113negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93490701
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93490701
115negative regulation of sister chromatid segregation (GO:0033046)2.93490701
116regulation of telomere maintenance via telomerase (GO:0032210)2.92574027
117DNA packaging (GO:0006323)2.92093353
118regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92043392
119histone exchange (GO:0043486)2.91610352
120telomere maintenance via telomere lengthening (GO:0010833)2.91275171
121mRNA export from nucleus (GO:0006406)2.90709090
122chromosome segregation (GO:0007059)2.90557926
123RNA export from nucleus (GO:0006405)2.90083289
124regulation of DNA damage checkpoint (GO:2000001)2.87562950
125spindle checkpoint (GO:0031577)2.85631857
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.84783476
127ribosome biogenesis (GO:0042254)2.84728506
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84724382
129maturation of SSU-rRNA (GO:0030490)2.84003841
130ribosome assembly (GO:0042255)2.83495165
131purine nucleobase biosynthetic process (GO:0009113)2.81589266
132negative regulation of chromosome segregation (GO:0051985)2.81253331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.68639118
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.35968609
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.55009629
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.45630209
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.39747868
6MYC_22102868_ChIP-Seq_BL_Human2.86403898
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69772028
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.66387551
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63108591
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.49319405
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.40124101
12AR_21909140_ChIP-Seq_LNCAP_Human2.33287826
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29436819
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03052816
15E2F7_22180533_ChIP-Seq_HELA_Human10.8990667
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.97070171
17CIITA_25753668_ChIP-Seq_RAJI_Human1.95110025
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93664778
19* XRN2_22483619_ChIP-Seq_HELA_Human1.93186386
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86081848
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82341273
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.81926315
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79613930
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77725447
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77314969
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75911371
27KDM5A_27292631_Chip-Seq_BREAST_Human1.75748059
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72306222
29VDR_23849224_ChIP-Seq_CD4+_Human1.67926884
30FOXP3_21729870_ChIP-Seq_TREG_Human1.66938590
31VDR_21846776_ChIP-Seq_THP-1_Human1.65409469
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.62708745
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62076433
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.61357636
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55233897
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51143907
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48678483
38MYC_18940864_ChIP-ChIP_HL60_Human1.42565477
39* TTF2_22483619_ChIP-Seq_HELA_Human1.40535910
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39211195
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36991574
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36262456
43* GABP_19822575_ChIP-Seq_HepG2_Human1.35540992
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35279210
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31412204
46ELK1_19687146_ChIP-ChIP_HELA_Human1.30787906
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29913013
48* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28534301
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28521582
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28361793
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28098348
52* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27046620
53TCF7_22412390_ChIP-Seq_EML_Mouse1.24180298
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23577460
55MYB_26560356_Chip-Seq_TH1_Human1.22876226
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22277489
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22166232
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21740310
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20901539
60DCP1A_22483619_ChIP-Seq_HELA_Human1.19437356
61UTX_26944678_Chip-Seq_JUKART_Human1.19277035
62* GABP_17652178_ChIP-ChIP_JURKAT_Human1.19082074
63* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18680690
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18027108
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16272088
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15834032
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.15805811
68MYB_26560356_Chip-Seq_TH2_Human1.15273279
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13725422
70MAF_26560356_Chip-Seq_TH1_Human1.11547965
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11321936
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11111024
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10764187
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10541179
75TFEB_21752829_ChIP-Seq_HELA_Human1.10244638
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09523182
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07999476
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06996447
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.06236006
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05366015
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04407540
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04092506
83* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03312532
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03176550
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03000037
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01154767
87SPI1_23547873_ChIP-Seq_NB4_Human1.00291127
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.99882559
89NANOG_16153702_ChIP-ChIP_HESCs_Human0.98970797
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.98948413
91PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98094058
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97495748
93EWS_26573619_Chip-Seq_HEK293_Human0.96986208
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.94365120
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93435880
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91841606
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91700358
98FUS_26573619_Chip-Seq_HEK293_Human0.91632651
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90781005
100FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89773128
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89028045
102CHD1_26751641_Chip-Seq_LNCaP_Human0.88249214
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87763920
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87743153
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87217579
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86693468
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85999632
108KDM2B_26808549_Chip-Seq_DND41_Human0.85937438
109NCOR1_26117541_ChIP-Seq_K562_Human0.85797265
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82725915
111RUNX1_22412390_ChIP-Seq_EML_Mouse0.81842120
112* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80422824
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.79933580
114MAF_26560356_Chip-Seq_TH2_Human0.79677986
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78281698
116KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78281698
117KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78281698
118SCL_19346495_ChIP-Seq_HPC-7_Human0.77690122
119PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77411948
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76640821
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75486399
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74400303
123POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71766669
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68944724
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68748067
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.68509219
127TBX5_21415370_ChIP-Seq_HL-1_Mouse0.62162498
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.59638811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.42203920
2MP0003693_abnormal_embryo_hatching4.35129100
3MP0003111_abnormal_nucleus_morphology4.09848978
4MP0003077_abnormal_cell_cycle3.67363954
5MP0008057_abnormal_DNA_replication3.61429126
6MP0004957_abnormal_blastocyst_morpholog3.42005148
7MP0008877_abnormal_DNA_methylation3.05250673
8MP0002396_abnormal_hematopoietic_system3.04648776
9MP0008058_abnormal_DNA_repair2.84104201
10MP0010352_gastrointestinal_tract_polyps2.68072898
11MP0006292_abnormal_olfactory_placode2.59925118
12MP0009379_abnormal_foot_pigmentation2.48744801
13MP0001730_embryonic_growth_arrest2.45113812
14MP0008007_abnormal_cellular_replicative2.41382094
15MP0000350_abnormal_cell_proliferation2.33585486
16MP0005076_abnormal_cell_differentiation2.30759124
17MP0010307_abnormal_tumor_latency2.25820150
18MP0003123_paternal_imprinting2.22013766
19MP0004808_abnormal_hematopoietic_stem2.15522215
20MP0001672_abnormal_embryogenesis/_devel1.91810874
21MP0005380_embryogenesis_phenotype1.91810874
22MP0003763_abnormal_thymus_physiology1.84341505
23MP0003984_embryonic_growth_retardation1.79939906
24MP0001697_abnormal_embryo_size1.78146686
25MP0008932_abnormal_embryonic_tissue1.78056506
26MP0003121_genomic_imprinting1.77534666
27MP0002088_abnormal_embryonic_growth/wei1.75429041
28MP0002084_abnormal_developmental_patter1.72267593
29MP0000569_abnormal_digit_pigmentation1.65342229
30MP0009697_abnormal_copulation1.65048549
31MP0000703_abnormal_thymus_morphology1.63449001
32MP0003718_maternal_effect1.62618055
33MP0002085_abnormal_embryonic_tissue1.61855912
34MP0003941_abnormal_skin_development1.60334334
35MP0000490_abnormal_crypts_of1.59921034
36MP0003787_abnormal_imprinting1.59443940
37MP0002086_abnormal_extraembryonic_tissu1.58903188
38MP0004197_abnormal_fetal_growth/weight/1.58722557
39MP0003890_abnormal_embryonic-extraembry1.53803662
40MP0002080_prenatal_lethality1.51897033
41MP0002938_white_spotting1.49054079
42MP0005397_hematopoietic_system_phenotyp1.45929504
43MP0001545_abnormal_hematopoietic_system1.45929504
44MP0000313_abnormal_cell_death1.44550806
45MP0002019_abnormal_tumor_incidence1.44347131
46MP0002398_abnormal_bone_marrow1.43549342
47MP0009278_abnormal_bone_marrow1.39767364
48MP0004233_abnormal_muscle_weight1.36194602
49MP0003786_premature_aging1.32336227
50MP0001286_abnormal_eye_development1.30493437
51MP0002163_abnormal_gland_morphology1.28572260
52MP0002877_abnormal_melanocyte_morpholog1.23728989
53MP0002210_abnormal_sex_determination1.22000954
54MP0002722_abnormal_immune_system1.21549048
55MP0003567_abnormal_fetal_cardiomyocyte1.18727084
56MP0003705_abnormal_hypodermis_morpholog1.15550931
57MP0000689_abnormal_spleen_morphology1.14297149
58MP0002166_altered_tumor_susceptibility1.14145855
59MP0002160_abnormal_reproductive_system1.13593915
60MP0000566_synostosis1.09755929
61MP0009672_abnormal_birth_weight1.09507779
62MP0004264_abnormal_extraembryonic_tissu1.05471040
63MP0001145_abnormal_male_reproductive1.04101858
64MP0001293_anophthalmia1.03793311
65MP0009333_abnormal_splenocyte_physiolog1.03687132
66MP0010030_abnormal_orbit_morphology1.03328638
67MP0001929_abnormal_gametogenesis1.03009672
68MP0002006_tumorigenesis1.00783630
69MP0001849_ear_inflammation0.99442861
70MP0002429_abnormal_blood_cell0.99253435
71MP0001800_abnormal_humoral_immune0.99125518
72MP0001915_intracranial_hemorrhage0.98942769
73MP0003861_abnormal_nervous_system0.98697912
74MP0000733_abnormal_muscle_development0.97596297
75MP0009703_decreased_birth_body0.97524632
76MP0009053_abnormal_anal_canal0.96951283
77MP0000716_abnormal_immune_system0.96870408
78MP0003755_abnormal_palate_morphology0.95589701
79MP0002111_abnormal_tail_morphology0.95401198
80MP0002009_preneoplasia0.92309140
81MP0000653_abnormal_sex_gland0.90654645
82MP0000049_abnormal_middle_ear0.90533233
83MP0008995_early_reproductive_senescence0.89802809
84MP0006035_abnormal_mitochondrial_morpho0.89488552
85MP0003300_gastrointestinal_ulcer0.87887055
86MP0000428_abnormal_craniofacial_morphol0.87137823
87MP0003315_abnormal_perineum_morphology0.86644690
88MP0002233_abnormal_nose_morphology0.85762621
89MP0001873_stomach_inflammation0.85743938
90MP0000537_abnormal_urethra_morphology0.84752188
91MP0000358_abnormal_cell_content/0.84666120
92MP0005621_abnormal_cell_physiology0.83140058
93MP0008789_abnormal_olfactory_epithelium0.82724021
94MP0003119_abnormal_digestive_system0.82374045
95MP0002925_abnormal_cardiovascular_devel0.81773842
96MP0003566_abnormal_cell_adhesion0.80850211
97MP0005174_abnormal_tail_pigmentation0.80737987
98MP0005023_abnormal_wound_healing0.80668386
99MP0002420_abnormal_adaptive_immunity0.78377011
100MP0002092_abnormal_eye_morphology0.78291694
101MP0005384_cellular_phenotype0.78092643
102MP0002405_respiratory_system_inflammati0.76737541
103MP0004185_abnormal_adipocyte_glucose0.76672645
104MP0001819_abnormal_immune_cell0.76547765
105MP0003303_peritoneal_inflammation0.75260532
106MP0005408_hypopigmentation0.74525576
107MP0002452_abnormal_antigen_presenting0.74092053
108MP0003136_yellow_coat_color0.73844201
109MP0000631_abnormal_neuroendocrine_gland0.72769075
110MP0000432_abnormal_head_morphology0.72395783
111MP0003943_abnormal_hepatobiliary_system0.71854082
112MP0003115_abnormal_respiratory_system0.71787410
113MP0001485_abnormal_pinna_reflex0.71307080
114MP0001119_abnormal_female_reproductive0.70791469
115MP0001188_hyperpigmentation0.70777556
116MP0000477_abnormal_intestine_morphology0.70585838
117MP0003221_abnormal_cardiomyocyte_apopto0.69840688
118MP0003942_abnormal_urinary_system0.69123832
119MP0005389_reproductive_system_phenotype0.68492805
120MP0000371_diluted_coat_color0.67858432
121MP0002081_perinatal_lethality0.67198714
122MP0010155_abnormal_intestine_physiology0.67008482
123MP0003937_abnormal_limbs/digits/tail_de0.66405806
124MP0003385_abnormal_body_wall0.65152869
125MP0002697_abnormal_eye_size0.64907562
126MP0003698_abnormal_male_reproductive0.64888047
127MP0003935_abnormal_craniofacial_develop0.64740388
128MP0005394_taste/olfaction_phenotype0.64217003
129MP0005499_abnormal_olfactory_system0.64217003
130MP0002723_abnormal_immune_serum0.64199300
131MP0000579_abnormal_nail_morphology0.64110191
132MP0002114_abnormal_axial_skeleton0.64022862
133MP0005671_abnormal_response_to0.63366002
134MP0001835_abnormal_antigen_presentation0.63265724
135MP0000266_abnormal_heart_morphology0.62673551
136MP0002653_abnormal_ependyma_morphology0.62636063
137MP0002075_abnormal_coat/hair_pigmentati0.62285358
138MP0008770_decreased_survivor_rate0.61583621
139MP0003938_abnormal_ear_development0.61202085
140MP0002095_abnormal_skin_pigmentation0.60890868
141MP0003936_abnormal_reproductive_system0.60536738
142MP0002161_abnormal_fertility/fecundity0.59976794
143MP0006036_abnormal_mitochondrial_physio0.59818605
144MP0001919_abnormal_reproductive_system0.59739732
145MP0001186_pigmentation_phenotype0.59692155
146MP0005391_vision/eye_phenotype0.59220817
147MP0000762_abnormal_tongue_morphology0.58749611

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.13084127
2Abnormality of the fingertips (HP:0001211)3.96609514
3Chromsome breakage (HP:0040012)3.65767585
4Abnormality of cells of the erythroid lineage (HP:0012130)3.50205833
5Medulloblastoma (HP:0002885)3.42340588
6Macrocytic anemia (HP:0001972)3.37222977
7Ependymoma (HP:0002888)3.31782697
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.14981641
9Colon cancer (HP:0003003)3.04884509
10Ectopic kidney (HP:0000086)3.02261010
11Increased nuchal translucency (HP:0010880)3.00723895
12Birth length less than 3rd percentile (HP:0003561)2.99798532
13Abnormality of chromosome stability (HP:0003220)2.99572365
14Aplasia/Hypoplasia of the sacrum (HP:0008517)2.91513199
15Prominent nose (HP:0000448)2.87991253
16Long eyelashes (HP:0000527)2.87776661
17Pallor (HP:0000980)2.82568734
18Short 4th metacarpal (HP:0010044)2.78896170
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.78896170
20Proximal placement of thumb (HP:0009623)2.77686120
21Basal cell carcinoma (HP:0002671)2.75527512
22Deviation of the thumb (HP:0009603)2.71435500
23Impulsivity (HP:0100710)2.65736315
24Urethral obstruction (HP:0000796)2.63931167
25Patellar aplasia (HP:0006443)2.63374310
26Selective tooth agenesis (HP:0001592)2.55713920
27Abnormality of the astrocytes (HP:0100707)2.53822632
28Astrocytoma (HP:0009592)2.53822632
29Nephroblastoma (Wilms tumor) (HP:0002667)2.50761133
30Abnormal number of erythroid precursors (HP:0012131)2.46814854
31Myelodysplasia (HP:0002863)2.45736218
32Abnormality of the preputium (HP:0100587)2.45509798
33Triphalangeal thumb (HP:0001199)2.45348516
34Aplasia/Hypoplasia of the patella (HP:0006498)2.45036768
35Abnormal number of incisors (HP:0011064)2.42974906
36Neoplasm of the oral cavity (HP:0100649)2.40890702
37Horseshoe kidney (HP:0000085)2.39456688
38Overriding aorta (HP:0002623)2.39220058
39Duplication of thumb phalanx (HP:0009942)2.38912523
40Meckel diverticulum (HP:0002245)2.38708616
41Embryonal renal neoplasm (HP:0011794)2.35594271
42Rhabdomyosarcoma (HP:0002859)2.35315385
43High pitched voice (HP:0001620)2.31964567
44Acute myeloid leukemia (HP:0004808)2.30707287
45Reticulocytopenia (HP:0001896)2.30346164
46Glioma (HP:0009733)2.30076364
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.27462016
48Bifid tongue (HP:0010297)2.26537382
49Abnormality of the ileum (HP:0001549)2.25233704
50Abnormality of cochlea (HP:0000375)2.24979369
51Progressive muscle weakness (HP:0003323)2.22147608
52Neoplasm of striated muscle (HP:0009728)2.21064654
53Missing ribs (HP:0000921)2.20551246
54Degeneration of anterior horn cells (HP:0002398)2.19570113
55Abnormality of the anterior horn cell (HP:0006802)2.19570113
56Oral leukoplakia (HP:0002745)2.18915556
57Cutis marmorata (HP:0000965)2.17740803
58Abnormality of the labia minora (HP:0012880)2.15958096
59Anal stenosis (HP:0002025)2.14831856
60Stenosis of the external auditory canal (HP:0000402)2.13565277
61T lymphocytopenia (HP:0005403)2.12846882
62Abnormal lung lobation (HP:0002101)2.12773165
63Abnormality of the phalanges of the hallux (HP:0010057)2.12100430
64Biliary tract neoplasm (HP:0100574)2.12016846
65Abnormality of the duodenum (HP:0002246)2.09109331
66Multiple enchondromatosis (HP:0005701)2.08528710
67Supernumerary ribs (HP:0005815)2.07883360
68Gastrointestinal carcinoma (HP:0002672)2.07186426
69Malignant gastrointestinal tract tumors (HP:0006749)2.07186426
70Cafe-au-lait spot (HP:0000957)2.06116234
71Neoplasm of the adrenal cortex (HP:0100641)2.06087376
72Absent thumb (HP:0009777)2.03706056
73Squamous cell carcinoma (HP:0002860)2.03499011
74Acute lymphatic leukemia (HP:0006721)2.03393626
75Truncal obesity (HP:0001956)2.03255785
76Agnosia (HP:0010524)2.03140948
77Trigonocephaly (HP:0000243)2.00803435
78Sloping forehead (HP:0000340)2.00786583
79Progressive external ophthalmoplegia (HP:0000590)2.00477674
80Elfin facies (HP:0004428)2.00147965
81Abnormality of the carotid arteries (HP:0005344)2.00119093
82Absent forearm bone (HP:0003953)1.99727528
83Aplasia involving forearm bones (HP:0009822)1.99727528
84Clubbing of toes (HP:0100760)1.98419239
85Amaurosis fugax (HP:0100576)1.97924420
86Low anterior hairline (HP:0000294)1.97056636
87Deep philtrum (HP:0002002)1.96093000
88Papillary thyroid carcinoma (HP:0002895)1.95968184
89Small intestinal stenosis (HP:0012848)1.95794301
90Duodenal stenosis (HP:0100867)1.95794301
91Esophageal atresia (HP:0002032)1.94409128
92Skin tags (HP:0010609)1.94075181
93Partial duplication of thumb phalanx (HP:0009944)1.92548947
94Breast hypoplasia (HP:0003187)1.92114687
95Supernumerary bones of the axial skeleton (HP:0009144)1.91812703
96Hypoplasia of the radius (HP:0002984)1.90677144
97Renal duplication (HP:0000075)1.90510730
98Neoplasm of the pancreas (HP:0002894)1.90473708
99Hyperacusis (HP:0010780)1.89829503
100Atresia of the external auditory canal (HP:0000413)1.89590212
101Facial hemangioma (HP:0000329)1.89241532
102Lymphoma (HP:0002665)1.88578471
103Abnormality of T cell number (HP:0011839)1.88435921
104Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86539493
105Abnormality of alanine metabolism (HP:0010916)1.86539493
106Hyperalaninemia (HP:0003348)1.86539493
107Abnormality of DNA repair (HP:0003254)1.86132964
108Abnormality of midbrain morphology (HP:0002418)1.85552245
109Molar tooth sign on MRI (HP:0002419)1.85552245
110Broad palm (HP:0001169)1.85398373
111Blepharitis (HP:0000498)1.85205911
112Abnormality of the 4th metacarpal (HP:0010012)1.84858298
113Choanal atresia (HP:0000453)1.84657529
114Rectovaginal fistula (HP:0000143)1.84570656
115Rectal fistula (HP:0100590)1.84570656
116Sandal gap (HP:0001852)1.82693767
117Short thumb (HP:0009778)1.81449448
118Heterotopia (HP:0002282)1.80827429
119Overlapping toe (HP:0001845)1.80027848
120Absent radius (HP:0003974)1.80026761
121Poikiloderma (HP:0001029)1.79217099
122IgM deficiency (HP:0002850)1.78189899
123Pelvic girdle muscle weakness (HP:0003749)1.78167844
124Short middle phalanx of the 5th finger (HP:0004220)1.78102260
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78042213
126B lymphocytopenia (HP:0010976)1.77948041
127Abnormality of B cell number (HP:0010975)1.77948041
128Hypoplasia of the pons (HP:0012110)1.77686393
129Cellular immunodeficiency (HP:0005374)1.77448070
130Recurrent viral infections (HP:0004429)1.76945186
131Abnormality of reticulocytes (HP:0004312)1.76379547
132Tracheoesophageal fistula (HP:0002575)1.76202974
13311 pairs of ribs (HP:0000878)1.75099428
134Facial cleft (HP:0002006)1.74594173
135Arteriovenous malformation (HP:0100026)1.73539263
136Preauricular skin tag (HP:0000384)1.72988937
137Bone marrow hypocellularity (HP:0005528)1.72205295
138Abnormality of homocysteine metabolism (HP:0010919)1.72136503
139Homocystinuria (HP:0002156)1.72136503
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.71700895
141Skull defect (HP:0001362)1.71618189
142Premature graying of hair (HP:0002216)1.71489772
143Cleft eyelid (HP:0000625)1.70247846
144Cutaneous melanoma (HP:0012056)1.69361367
145Neoplasm of the colon (HP:0100273)1.67543932
146Partial agenesis of the corpus callosum (HP:0001338)1.67478698
147Obsessive-compulsive behavior (HP:0000722)1.66758442
148Abnormality of the diencephalon (HP:0010662)1.66725018
149Lip pit (HP:0100267)1.66331247
150Intestinal fistula (HP:0100819)1.65504252
151Embryonal neoplasm (HP:0002898)1.64804688
152Premature ovarian failure (HP:0008209)1.64246595
153Capillary hemangiomas (HP:0005306)1.62773829
154Cortical dysplasia (HP:0002539)1.61688450
155High anterior hairline (HP:0009890)1.61347107
156Abnormality of the pons (HP:0007361)1.60535787
157Abnormality of the septum pellucidum (HP:0007375)1.60485774
158Preaxial hand polydactyly (HP:0001177)1.59119684
159Diastasis recti (HP:0001540)1.59012037

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.14285419
2CDK124.57802855
3NEK23.00079050
4EEF2K2.73212912
5WEE12.59710744
6BRD42.45688847
7SRPK12.39076705
8MAP3K102.28090891
9TAF12.23744641
10TTK2.23513922
11ATR2.04242088
12ZAK2.02686582
13STK101.92645089
14MKNK11.90558894
15MAP4K11.85105750
16BUB11.84547186
17PBK1.78392731
18EIF2AK11.78129983
19VRK21.76908057
20NEK11.73228971
21RPS6KB21.71619956
22CDK41.68078373
23PASK1.67219846
24CHEK11.63469655
25TSSK61.61718583
26PLK11.59195331
27MKNK21.57288387
28AURKB1.55098494
29CDK71.50389742
30ACVR1B1.50137745
31PLK41.47014997
32ALK1.41853152
33MST41.41411544
34CHEK21.37769129
35BRSK21.35477674
36CDK61.30399773
37PKN21.29570812
38RPS6KA41.28133771
39ATM1.27685065
40PLK31.22145534
41NME11.20595556
42LATS11.18808185
43CDK21.15144869
44SMG11.11381718
45PIM11.08850623
46STK41.08793053
47STK31.08371113
48MTOR1.06759717
49MAP3K81.06286354
50JAK31.03474776
51MELK1.02675087
52TNIK1.01538054
53STK160.96077768
54PNCK0.91562786
55EIF2AK30.90798575
56DYRK30.88640547
57FGFR30.88147139
58PDK20.87879259
59VRK10.85681327
60CDK10.84041207
61CDK30.77723056
62EIF2AK20.77457070
63LATS20.75451361
64TGFBR10.74917389
65NUAK10.74310322
66CDK90.74126029
67MARK30.73712585
68BRSK10.72997085
69CLK10.72188610
70BTK0.71291345
71FLT30.70039880
72ZAP700.68113568
73WNK40.66909124
74CAMK1D0.66704661
75TXK0.66375547
76ERBB40.64934673
77FGFR10.63480406
78PRKDC0.62753424
79SCYL20.61490546
80PTK60.61444695
81CSNK1E0.61168583
82TRIM280.61074548
83NME20.60944180
84RIPK10.60883546
85MAP3K90.60776449
86ITK0.59819726
87TYRO30.59479628
88GRK60.58726286
89* CSNK2A20.58416061
90CHUK0.58364630
91PAK40.58042217
92MAPK140.55883838
93CAMK1G0.55756036
94LRRK20.55704585
95CSNK1D0.54672686
96ICK0.54104005
97SIK20.53962387
98TESK20.53148319
99AURKA0.52576595
100PDGFRA0.50938106
101BMPR1B0.50577564
102TTN0.49251130
103FGFR40.45533025
104MST1R0.45448893
105CSF1R0.45063788
106FGFR20.41655265
107AKT10.40711649
108GSK3B0.40494909
109CCNB10.39912343
110MAP3K40.39551107
111PDGFRB0.39059918
112STK240.38802927
113DMPK0.37961677
114PAK20.37424018
115STK38L0.37230006
116MAPKAPK50.36816259
117CSNK2A10.36477497
118LCK0.36477034
119TEC0.36032339
120CDK80.35693242
121MAPK10.35542407
122BRAF0.34287210
123PRKCI0.34240382
124TYK20.33858611
125RPS6KB10.33822297
126MAP2K30.33527399
127PRKACB0.32839850
128TRIB30.31637148
129WNK10.31596455
130RPS6KA10.30761911
131KIT0.29887153
132CDK11A0.29579032
133PLK20.28616062
134DYRK20.28066435
135STK390.28036661
136AKT20.27895312

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19669819
2Mismatch repair_Homo sapiens_hsa034303.50662599
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32438257
4* Spliceosome_Homo sapiens_hsa030403.29523062
5RNA transport_Homo sapiens_hsa030133.10156806
6Cell cycle_Homo sapiens_hsa041102.92699837
7Base excision repair_Homo sapiens_hsa034102.69649846
8Homologous recombination_Homo sapiens_hsa034402.50699269
9One carbon pool by folate_Homo sapiens_hsa006702.48823660
10mRNA surveillance pathway_Homo sapiens_hsa030152.39489460
11Non-homologous end-joining_Homo sapiens_hsa034502.27848814
12Fanconi anemia pathway_Homo sapiens_hsa034602.27304080
13Nucleotide excision repair_Homo sapiens_hsa034202.22379704
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.00461697
15RNA degradation_Homo sapiens_hsa030181.89821267
16RNA polymerase_Homo sapiens_hsa030201.80984161
17Basal transcription factors_Homo sapiens_hsa030221.73824047
18Protein export_Homo sapiens_hsa030601.64648471
19p53 signaling pathway_Homo sapiens_hsa041151.62485298
20Primary immunodeficiency_Homo sapiens_hsa053401.49695914
21Ribosome_Homo sapiens_hsa030101.46643507
22Herpes simplex infection_Homo sapiens_hsa051681.46350224
23Pyrimidine metabolism_Homo sapiens_hsa002401.41023712
24Antigen processing and presentation_Homo sapiens_hsa046121.37022586
25Epstein-Barr virus infection_Homo sapiens_hsa051691.30916313
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30752213
27Viral carcinogenesis_Homo sapiens_hsa052031.29094046
28MicroRNAs in cancer_Homo sapiens_hsa052061.27962392
29Lysine degradation_Homo sapiens_hsa003101.24754662
30HTLV-I infection_Homo sapiens_hsa051661.24591338
31Huntingtons disease_Homo sapiens_hsa050161.17276407
32Oxidative phosphorylation_Homo sapiens_hsa001901.15881396
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14923806
34Small cell lung cancer_Homo sapiens_hsa052221.14529071
35Parkinsons disease_Homo sapiens_hsa050121.13696752
36Notch signaling pathway_Homo sapiens_hsa043301.11428089
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10993410
38Oocyte meiosis_Homo sapiens_hsa041141.08046289
39Chronic myeloid leukemia_Homo sapiens_hsa052201.06375188
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.03852236
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98550480
42Pyruvate metabolism_Homo sapiens_hsa006200.97821794
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97740295
44Colorectal cancer_Homo sapiens_hsa052100.94002032
45Hepatitis B_Homo sapiens_hsa051610.89334571
46mTOR signaling pathway_Homo sapiens_hsa041500.88602553
47T cell receptor signaling pathway_Homo sapiens_hsa046600.88145642
48Selenocompound metabolism_Homo sapiens_hsa004500.87370635
49Systemic lupus erythematosus_Homo sapiens_hsa053220.87051727
50B cell receptor signaling pathway_Homo sapiens_hsa046620.86895503
51Measles_Homo sapiens_hsa051620.86619385
52Adherens junction_Homo sapiens_hsa045200.85553218
53Thyroid cancer_Homo sapiens_hsa052160.81561598
54Non-small cell lung cancer_Homo sapiens_hsa052230.80970665
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79376534
56Acute myeloid leukemia_Homo sapiens_hsa052210.76247713
57Viral myocarditis_Homo sapiens_hsa054160.74945489
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74523082
59Propanoate metabolism_Homo sapiens_hsa006400.73146153
60Steroid biosynthesis_Homo sapiens_hsa001000.71980569
61Purine metabolism_Homo sapiens_hsa002300.71737905
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71461915
63Apoptosis_Homo sapiens_hsa042100.70411982
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69716632
65Basal cell carcinoma_Homo sapiens_hsa052170.69496771
66Pancreatic cancer_Homo sapiens_hsa052120.68236083
67Influenza A_Homo sapiens_hsa051640.68121901
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68068520
69Folate biosynthesis_Homo sapiens_hsa007900.65582437
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65413538
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65291425
72Proteasome_Homo sapiens_hsa030500.64951449
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.64705851
74Endometrial cancer_Homo sapiens_hsa052130.64598951
75Prostate cancer_Homo sapiens_hsa052150.64527843
76Hematopoietic cell lineage_Homo sapiens_hsa046400.64231344
77TGF-beta signaling pathway_Homo sapiens_hsa043500.64056595
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63541555
79Carbon metabolism_Homo sapiens_hsa012000.61573757
80Alzheimers disease_Homo sapiens_hsa050100.60568470
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60103305
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59764283
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58895188
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56265058
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55912646
86Hippo signaling pathway_Homo sapiens_hsa043900.55893199
87Pathways in cancer_Homo sapiens_hsa052000.55750913
88FoxO signaling pathway_Homo sapiens_hsa040680.55398851
89Shigellosis_Homo sapiens_hsa051310.55216434
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.54760545
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54258970
92Leishmaniasis_Homo sapiens_hsa051400.54242642
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52989869
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52428612
95Legionellosis_Homo sapiens_hsa051340.51201462
96Vitamin B6 metabolism_Homo sapiens_hsa007500.50326866
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.50228273
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.49577836
99Toxoplasmosis_Homo sapiens_hsa051450.49262924
100Proteoglycans in cancer_Homo sapiens_hsa052050.48494696
101Wnt signaling pathway_Homo sapiens_hsa043100.44443643
102Osteoclast differentiation_Homo sapiens_hsa043800.42987360
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.42891098
104HIF-1 signaling pathway_Homo sapiens_hsa040660.42835564
105Pentose phosphate pathway_Homo sapiens_hsa000300.42316085
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.41693851
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39943760
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38502864
109Biosynthesis of amino acids_Homo sapiens_hsa012300.36556165
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36142903
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35533275
112Cardiac muscle contraction_Homo sapiens_hsa042600.34952870
113Inositol phosphate metabolism_Homo sapiens_hsa005620.33977747
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32632640
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.32304356
116Metabolic pathways_Homo sapiens_hsa011000.31763204
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30477151
118TNF signaling pathway_Homo sapiens_hsa046680.30041030
119Hedgehog signaling pathway_Homo sapiens_hsa043400.29944694
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29733834
121Glioma_Homo sapiens_hsa052140.28933569
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28787886
123Bladder cancer_Homo sapiens_hsa052190.28682829
124Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28391030
125Prolactin signaling pathway_Homo sapiens_hsa049170.28283783
126VEGF signaling pathway_Homo sapiens_hsa043700.27877160
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27627026
128Platelet activation_Homo sapiens_hsa046110.26697581
129Dorso-ventral axis formation_Homo sapiens_hsa043200.25778332
130Fatty acid biosynthesis_Homo sapiens_hsa000610.25376681
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24448916
132Glutathione metabolism_Homo sapiens_hsa004800.24328738
133Melanoma_Homo sapiens_hsa052180.23878069
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23841399
135Tight junction_Homo sapiens_hsa045300.22439393
136Fatty acid metabolism_Homo sapiens_hsa012120.21446001
137Vitamin digestion and absorption_Homo sapiens_hsa049770.20457540
138Thyroid hormone synthesis_Homo sapiens_hsa049180.13477510
139N-Glycan biosynthesis_Homo sapiens_hsa005100.11969254
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.10177525
141Fatty acid elongation_Homo sapiens_hsa000620.09186081
142Arginine and proline metabolism_Homo sapiens_hsa003300.07161031
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05842740
144Glucagon signaling pathway_Homo sapiens_hsa049220.03937792
145Sulfur relay system_Homo sapiens_hsa041220.02441743
146Renal cell carcinoma_Homo sapiens_hsa052110.01706808

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